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Journal articles on the topic 'Suco de melancia'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Silva, Raphaela Maceió, Rossana Maria Feitosa de Figueirêdo, Alexandre José de Melo Queiroz, and Regilane Marques Feitosa. "Processamento e caracterização físico-química do suco misto melancia com pepino." Revista Verde de Agroecologia e Desenvolvimento Sustentável 11, no. 3 (2016): 65. http://dx.doi.org/10.18378/rvads.v11i3.4087.

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<p>A junção da melancia com pepino trás grandes benefícios na melhoria da composição físico-química do produto. O suco misto de frutas vem sendo estudado para revelar as características nutricionais e funcionais da mistura. Sendo a melancia rica em água, potássio, ferro, magnésio, zinco e vitamina C e o pepino apresentando baixo consumo de energia, baixo teor de calorias e pequenas quantidades de vitamina C, a elaboração desses combinados aumenta a possibilidade de efeitos benéficos ao organismo. Objetivou-se, com este estudo, elaborar suco misto de melancia com pepino em diferentes conc

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2

Paraense, Mariana Ogando, Priscila Euler Auler, and Kátia Cecilia de Souza Figueiredo. "CLARIFICAÇÃO DE SUCO DE MELANCIA ATRAVÉS DE MICROFILTRAÇÃO COM MEMBRANA DE ACETATO DE CELULOSE." Journal of Engineering and Exact Sciences 3, no. 3 (2017): 584–94. http://dx.doi.org/10.18540/jcecvl3iss3pp584-594.

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Uma das principais aplicações da microfiltração é a clarificação e concentração de sucos de fruta. O objetivo deste trabalho foi estudar a clarificação do suco de melancia usando membranas comerciais de acetato de celulose 0,45 μm. Para avaliar a eficiência do processo, foram determinadas as resistências à transferência de massa e as propriedades do suco. A permeabilidade hidraúlica da membrana foi de 1,5x10-3 m/sPa para a água e de 2,2x10-4 m/sPa para o suco. O permeado foi submetido a análises de cor, transparência, turbidez, pH, densidade, viscosidade, sólidos solúveis totais e acidez. O fl

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3

Cunha, Kelly Damasceno, Priscila Ribeiro da Silva, Ana Lígia Faria e. Silva da Fonseca Costa, Anderson Junger Teodoro, and Maria Gabriela Bello Koblitz. "Estabilidade de ácido ascórbico em sucos de frutas frescos sob diferentes formas de armazenamento." Brazilian Journal of Food Technology 17, no. 2 (2014): 139–45. http://dx.doi.org/10.1590/bjft.2014.016.

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O ácido ascórbico é uma vitamina hidrossolúvel de importância nutricional há muito estabelecida, por sua atuação como cofator em diversos processos fisiológicos e como antioxidante. O ser humano depende da ingestão diária desse micronutriente, cujas principais fontes são as frutas e hortaliças. Por ser um nutriente menos estável, o ácido ascórbico sofre perdas no processamento e no armazenamento, influenciadas por diversos fatores, como pH, temperatura, presença de íons, etc. A literatura apresenta escasso material sobre a estabilidade de ácido ascórbico em armazenamento doméstico, além de hav

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4

Ganesan, Anand K., Yoonjung Kho, Sung Chan Kim, Yue Chen, Yingming Zhao, and Michael A. White. "Broad spectrum identification of SUMO substrates in melanoma cells." PROTEOMICS 7, no. 13 (2007): 2216–21. http://dx.doi.org/10.1002/pmic.200600971.

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5

Broggio, J. W. "The truth, such as it is, about melanoma risk." BMJ 343, sep27 2 (2011): d6127. http://dx.doi.org/10.1136/bmj.d6127.

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6

Andrade, Pedro, David Serra, José Carlos Cardoso, Ricardo Vieira, João Duarte Freitas, and Américo Figueiredo. "RETALHO INTERPOLADO DO SULCO MELOLABIAL PARA ENCERRAMENTO DE DEFEITOS COMPLEXOS DO NARIZ." Journal of the Portuguese Society of Dermatology and Venereology 69, no. 3 (2011): 437. http://dx.doi.org/10.29021/spdv.69.3.80.

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O encerramento de defeitos cirúrgicos do nariz coloca dificuldades acrescidas, particularmente quando as suas características impedem o recurso a pele adjacente para o seu encerramento. A colocação local de enxertos, por outro lado, não permite uma optimização dos resultados cosméticos. Os retalhos interpolados, sendo colhidos à distância do defeito com base num pedículo aleatório e permanecendo ligados à região dadora durante um período de 10-21 dias, são uma alternativa viável nestes casos. Apresentamos um doente de 71 anos, referenciado após biopsia excisional de melanoma maligno de tipo an

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7

Menezes Filho, Antonio Carlos Pereira de, João Carlos Perbone de Souza, and Carlos Frederico De Souza Castro. "Avaliação dos parâmetros físico-químicos e tecnológicos da farinha produzida a partir dos resíduos da agroindústria de laranja e melancia." Agrarian 12, no. 45 (2019): 399–410. http://dx.doi.org/10.30612/agrarian.v12i45.9143.

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As indústrias processadoras de frutas que movem o setor agroindustrial geram diariamente volumosos conteúdos de resíduos após processo de beneficiamento dos frutos. Tanto os frutos da laranja e da melancia são descartados em aterros sem nenhum processo de beneficiamento destes resíduos que podem gerar lucros anuais sobre estes coprodutos. Este trabalho teve como objetivo o aproveitamento dos resíduos (cascas e albedos) de laranjas e melancias para a produção de farinhas, sob este contexto avaliar alguns parâmetros físico-químicos e tecnológicos destas farinhas. Os resíduos foram coletados em i

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8

Brennecke, Sabine, Martin Deichmann, Helmut Naeher, and Hjalmar Kurzen. "Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma." Melanoma Research 15, no. 6 (2005): 515–22. http://dx.doi.org/10.1097/00008390-200512000-00006.

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9

MCPHAIL, GAYE. "There's no such thing as a healthy glow: cutaneous malignant melanoma-the case against suntanning." European Journal of Cancer Care 6, no. 2 (1997): 147–53. http://dx.doi.org/10.1046/j.1365-2354.1997.00025.x.

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10

Fratesi, Lauren, Raed Alhusayen, and James Walker. "Case Report of Primary Rectal Melanoma and Review of the Etiology of Melanoma." Journal of Cutaneous Medicine and Surgery 12, no. 3 (2008): 117–20. http://dx.doi.org/10.2310/7750.2008.06004.

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Background: Primary rectal melanoma is a very rare and aggressive malignancy. It is defined as melanoma arising in the rectal mucosa, more than 4 cm from the anal verge. Objective: A case of primary rectal melanoma is reported, and the theories of the etiology of melanoma are reviewed. Methods and Results: This article reports a case of a 75-year-old woman who presented with lower gastrointestinal bleeding and abdominal discomfort. A polyp was removed from the low-lying rectum during colonoscopy. After immunohistochemical staining and microscopic examination, it was diagnosed as melanoma. Conc

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11

Brichard, V., A. Van Pel, T. Wölfel, et al. "The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas." Journal of Experimental Medicine 178, no. 2 (1993): 489–95. http://dx.doi.org/10.1084/jem.178.2.489.

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Lymphocytes of melanoma patients can be restimulated in vitro with autologous tumor cells to generate antitumor cytolytic T lymphocytes (CTL). Previous reports have indicated that, when such CTL are obtained from HLA-A2 melanoma patients, they often display broad reactivity on A2 melanoma cell lines. Such antitumor CTL clones, which appeared to recognize the same antigen, were isolated from two patients. We report here the cloning of a cDNA that directs the expression of the antigen recognized by these CTL. This cDNA corresponds to the transcript of the tyrosinase gene. The gene was found to b

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Geller, Joanna, Susan M. Swetter, Jenniffer Leyson, Donald R. Miller, Katie Brooks, and Alan C. Geller. "Crafting a Melanoma Educational Campaign to Reach Middle-Aged and Older Men." Journal of Cutaneous Medicine and Surgery 10, no. 6 (2006): 259–68. http://dx.doi.org/10.2310/7750.2006.00066.

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Background: From 1973 through 2002, melanoma mortality rates have risen steeply in middle-aged and older men. Men's higher mortality rate from melanoma is hardly an isolated example of the ways in which men's health lags behind women's health. Given the significantly higher melanoma mortality rates of men compared with women, there is now a need for a melanoma education program targeted to middle-aged and older men and their closest contacts, including spouses, significant others, and health care professionals. Objectives: In this article, we discuss the theoretical and practical foundations f

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13

Wang, Shu Jing, Jia Liu, Fei Wang, et al. "Tumstatin 7 Peptide Affect Biological Activity of B16 Melanoma Cell." Advanced Materials Research 641-642 (January 2013): 915–18. http://dx.doi.org/10.4028/www.scientific.net/amr.641-642.915.

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To study the effect of biological activity of Tumstatin 7 peptide on the cell proliferation and apoptosis of B16 melanoma. Tumstatin 7 peptide was synthesized and its purity is 98.4532% by high-performance liquid chromatography. The effect of 7 peptide on B16 melanoma was observed by MTT, cell growth curve, the observation of the transmission electron microscope (TEM). 7 peptide can significantly inhibit B16 melanoma cell proliferation, showing dose- and time-dependent .Its IC50 was 72.53 μg/ml.The morphology of B16 melanoma cell was obviously changed by TEM, such as karyopyknosis and apoptoti

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Paul, Sharad P. "Micromelanomas: A Review of Melanomas≤2 mm and a Case Report." Case Reports in Oncological Medicine 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/206260.

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The ABCD acronym used to screen pigmented lesions for melanoma obviously was not designed to contend with melanomas that are under 2 mm in diameter. Previously, views ranged that such small lesions could not be melanomas until a few reports of such “micromelanomas” emerged. The author presents a 2 mm melanoma in situ presenting as an insignificant pigmented lesion in a 60-year-old patient with no previous history of melanoma or multiple nevi—which is usually the norm in cases of small melanoma. This paper reiterates the fact that when it comes to a melanoma, size does not matter. In this paper

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15

Fujimura, Taku, Yumi Kambayashi, Kentaro Ohuchi, Yusuke Muto, and Setsuya Aiba. "Treatment of Advanced Melanoma: Past, Present and Future." Life 10, no. 9 (2020): 208. http://dx.doi.org/10.3390/life10090208.

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Therapeutic options for treating advanced melanoma are progressing rapidly. Until six years ago, the regimen for treating advanced melanoma mainly comprised cytotoxic agents such as dacarbazine, and type I interferons. Since 2014, anti-programmed cell death 1 (PD1) antibodies have become recognized as anchor drugs for treating advanced melanoma with or without additional combination drugs such as ipilimumab. In addition, v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase inhibitors in combination with mitogen-activated protein kinase kinase (MEK) inhibitors are among the most promisi

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16

van Poppelen, Natasha M., Daniël P. de Bruyn, Tolga Bicer, et al. "Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing." International Journal of Molecular Sciences 22, no. 1 (2020): 336. http://dx.doi.org/10.3390/ijms22010336.

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Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival melanoma. These malignancies derive from melanocytes in the uveal tract or conjunctiva. The genetic profiles of these different entities differ from each other. In uveal melanoma, GNAQ and GNA11 gene mutations are frequently found and prognosis is based on mutation status of BAP1, SF3B1 and EIF1AX genes. Iris melanoma, also originating from the uvea, has similarities to the genetic makeups of both posterior uveal melanoma (UM) and conjunctival melanoma since mutations in GNAQ and GNA11 are less common and gene

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17

Dumaz, Nicolas, Fanélie Jouenne, Julie Delyon, Samia Mourah, Armand Bensussan, and Céleste Lebbé. "Atypical BRAF and NRAS Mutations in Mucosal Melanoma." Cancers 11, no. 8 (2019): 1133. http://dx.doi.org/10.3390/cancers11081133.

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Primary mucosal melanomas represent a minority of melanomas, but have a significantly worse prognosis than cutaneous melanomas. A better characterization of the molecular pathogenesis of this melanoma subtype could help us understand the risk factors associated with the development of mucosal melanomas and highlight therapeutic targets. Because the Mitogen-Activated Protein Kinase (MAPK) pathway plays such a significant role in melanoma development, we explore v-raf murine sarcoma viral oncogene homolog B (BRAF) and neuroblastoma RAS viral oncogene homolog (NRAS) mutations in mucosal melanoma

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18

Sen Saxena, Vivek, Prashant Johri, and Avneesh Kumar. "AI-Enabled Support System for Melanoma Detection and Classification." International Journal of Reliable and Quality E-Healthcare 10, no. 4 (2021): 58–75. http://dx.doi.org/10.4018/ijrqeh.2021100104.

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Skin lesion melanoma is the deadliest type of cancer. Artificial intelligence provides the power to classify skin lesions as melanoma and non-melanoma. The proposed system for melanoma detection and classification involves four steps: pre-processing, resizing all the images, removing noise and hair from dermoscopic images; image segmentation, identifying the lesion area; feature extraction, extracting features from segmented lesion and classification; and categorizing lesion as malignant (melanoma) and benign (non-melanoma). Modified GrabCut algorithm is employed to generate skin lesion. Segme

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19

Mukherjee, Nabanita, Carol M. Amato, Jenette Skees, et al. "Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma." Cancers 12, no. 8 (2020): 2182. http://dx.doi.org/10.3390/cancers12082182.

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There is an urgent need to develop treatments for patients with melanoma who are refractory to or ineligible for immune checkpoint blockade, including patients who lack BRAF-V600E/K mutations. This is often the case in patients diagnosed with rare melanoma subtypes such as mucosal and acral melanoma. Here, we analyzed data from the cutaneous melanoma The Cancer Genome Atlas Network (TCGA) transcriptomic and proteomic databases for differential expression of apoptosis molecules between melanomas with or without BRAF hotspot mutations. Our data indicated higher B-cell CLL/lymphoma 2 (BCL2) expre

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Vannini, Ivan, Massimiliano Bonafe, Anna Tesei, et al. "Short Interfering RNA Directed against the SLUG Gene Increases Cell Death Induction in Human Melanoma Cell Lines Exposed to Cisplatin and Fotemustine." Analytical Cellular Pathology 29, no. 4 (2007): 279–87. http://dx.doi.org/10.1155/2007/540821.

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Background: Melanoma remains largely resistant to currently available chemotherapy, and new strategies have been proposed to flank standardized therapeutic protocols in an effort to improve efficacy. Such an approach requires good knowledge of the mechanisms involved in the resistance and survival of melanoma cells. In this context, the SLUG gene has recently been characterized as a major regulator of melanocytes and melanoma cell survival. Methods: We tested the hypothesis that an oligonucleotide-based short interfering RNA (siRNA) directed against the SLUG gene increases the susceptibility o

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Hay, Jennifer L., Carlos Baguer, Yuelin Li, Irene Orlow, and Marianne Berwick. "Interpretation of Melanoma Risk Feedback in First-Degree Relatives of Melanoma Patients." Journal of Cancer Epidemiology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/374842.

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Little is known about how individuals might interpret brief genetic risk feedback. We examined interpretation and behavioral intentions (sun protection, skin screening) in melanoma first-degree relatives (FDRs) after exposure to brief prototypic melanoma risk feedback. Using a 3 by 2 experimental pre-post design where feedback type (high-risk mutation, gene environment, and nongenetic) and risk level (positiveversusnegative findings) were systematically varied, 139 melanoma FDRs were randomized to receive one of the six scenarios. All scenarios included an explicit reminder that melanoma famil

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Soltantoyeh, Tahereh, Behnia Akbari, Amirali Karimi, et al. "Chimeric Antigen Receptor (CAR) T Cell Therapy for Metastatic Melanoma: Challenges and Road Ahead." Cells 10, no. 6 (2021): 1450. http://dx.doi.org/10.3390/cells10061450.

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Metastatic melanoma is the most aggressive and difficult to treat type of skin cancer, with a survival rate of less than 10%. Metastatic melanoma has conventionally been considered very difficult to treat; however, recent progress in understanding the cellular and molecular mechanisms involved in the tumorigenesis, metastasis and immune escape have led to the introduction of new therapies. These include targeted molecular therapy and novel immune-based approaches such as immune checkpoint blockade (ICB), tumor-infiltrating lymphocytes (TILs), and genetically engineered T-lymphocytes such as ch

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Sathyan, Jeena K., Manmohan Kamat, Varsha Sharma, Shravani Shetye, and Seema Barman. "Two case reports of malignant melanoma rectum." International Surgery Journal 8, no. 5 (2021): 1603. http://dx.doi.org/10.18203/2349-2902.isj20211838.

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Malignant melanoma of the rectum is an extremely rare disease. It typically presents in the fifth or sixth decade predominantly in female sex. The first symptoms are nonspecific such as bleeding, anal mass or pain. A timely diagnosis of melanoma is made even more difficult due to lack of obvious pigmentation and histologically amelanotic. Anorectal malignant melanoma spread along submucosal planes and are often beyond complete resection at the time of diagnosis. Prognosis is very poor. We present a rare case of malignant melanoma of rectum in a 21-year-old male, who was diagnosed at advanced s

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Sood, S., S. B. Nair, J. D. Fenwick, and K. Horgan. "Metastatic melanoma of the tonsil." Journal of Laryngology & Otology 113, no. 11 (1999): 1036–38. http://dx.doi.org/10.1017/s0022215100145931.

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AbstractMetastasis to the tonsils from malignant melanoma is rare. This paper describes one such case in a woman with synchronous breast adenocarcinoma and cutaneous malignant melanoma who had a most unusual clinical course.

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Weber, Daniela D., Maheshwor Thapa, Sepideh Aminzadeh-Gohari, et al. "Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts." Cancers 13, no. 3 (2021): 434. http://dx.doi.org/10.3390/cancers13030434.

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Melanomas are genetically and metabolically heterogeneous, which influences therapeutic efficacy and contributes to the development of treatment resistance in patients with metastatic disease. Metabolite phenotyping helps to better understand complex metabolic diseases, such as melanoma, and facilitates the development of novel therapies. Our aim was to characterize the tumor and plasma metabolomes of mice bearing genetically different melanoma xenografts. We engrafted the human melanoma cell lines A375 (BRAF mutant), WM47 (BRAF mutant), WM3000 (NRAS mutant), and WM3311 (BRAF, NRAS, NF1 triple

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King, Roy. "Lentiginous Melanoma." Archives of Pathology & Laboratory Medicine 135, no. 3 (2011): 337–41. http://dx.doi.org/10.5858/2009-0538-ra.1.

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Abstract Context.—Atypical lentiginous melanocytic lesions, particularly in older individuals, continue to pose a diagnostic challenge. Such lesions often show features intermediate between lentiginous nevus and melanoma in situ. We have recently defined within this group of lesions a histologic pattern of lentiginous melanoma, a slowly progressing variant of melanoma typically found on the trunk and proximal extremities of middle-aged and older individuals. Objective.—To review the clinical and histologic features of lentiginous melanoma and its histologic differential diagnosis. Data Sources

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Rajendharan, Keerthi Andi, Gurushankari Balakrishnan, Sudharsanan Sundaramurthi, Balamourougan Krishnaraj, and Sarath Chandra Sistla. "Ileal intussusception due to primary intestinal melanoma with generalized lymph node metastases- a rare cause of small bowel obstruction." International Surgery Journal 8, no. 2 (2021): 739. http://dx.doi.org/10.18203/2349-2902.isj20210394.

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Primary melanomas of small intestine are rare and most of them are metastases from cutaneous melanoma. The features distinguishing primary from metastatic intestinal melanoma are still under debate. Primary intestinal melanoma (PIM) is associated with a worse prognosis and a more aggressive behaviour due to its rapid growth. Hence, we report a case of primary ileal melanoma presenting as intussusception with generalized lymph node metastasis. A 69-year-old lady presented with recurrent abdominal pain, vomiting, distension and low grade fever. On examination, a 4*4 cm right inguinal lymph node

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Eftekhari, Hojat, Shabnam Fahim, Zeinab Aryanian, et al. "A Retrospective Large Original Study of Cutaneous Melanoma." Pakistan Journal of Medical and Health Sciences 15, no. 6 (2021): 1995–98. http://dx.doi.org/10.53350/pjmhs211561995.

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Background: The incidence of cutaneous malignant melanoma (CMM) has increased continuously during recent decades among many populations of the world. Cutaneous Malignant Melanoma is a malignancy with a demographic and ethnic disparity located in the skin and mucous membranous. The objective of this study is to determine Cutaneous Melanoma (CM) characteristics in Iran. Methods: This is a retrospective cross sectional study. We used data from Razi Hospital, Tehran University Melanoma Cancer Registry. The cases included in this study met the following criteria: primary CM, in situ or invasive, di

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Law, Matthew H., Lauren G. Aoude, David L. Duffy, et al. "Multiplex melanoma families are enriched for polygenic risk." Human Molecular Genetics 29, no. 17 (2020): 2976–85. http://dx.doi.org/10.1093/hmg/ddaa156.

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Abstract Cancers, including cutaneous melanoma, can cluster in families. In addition to environmental etiological factors such as ultraviolet radiation, cutaneous melanoma has a strong genetic component. Genetic risks for cutaneous melanoma range from rare, high-penetrance mutations to common, low-penetrance variants. Known high-penetrance mutations account for only about half of all densely affected cutaneous melanoma families, and the causes of familial clustering in the remainder are unknown. We hypothesize that some clustering is due to the cumulative effect of a large number of variants o

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Xin, Shengchang, Yingyi Wu, Zhijie Huang, Yisheng Huang, Bo Jia, and Jing Zhao. "Engineering Cell Membrane-Based Nanovesicles for Melanoma Tumor Treatment." Journal of Biomedical Nanotechnology 17, no. 5 (2021): 838–45. http://dx.doi.org/10.1166/jbn.2021.3072.

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Malignant melanoma has a poor prognosis because of its strong ability to invade tissues and metastasize. Immune checkpoint blockades significantly improve the clinical response in the development of melanoma. However, there are some obstacles to overcome, such as cost and limited application. Therefore, prospective approaches remain to be exploited. We designed cellular nanovesicles (NVs) expressing PD-1 to reactivate T cells by disrupting the PD-1/PD-L1 immunoinhibitory pathway. Furthermore, siNF90 was wrapped into PD-1 NVs to inhibit the proliferation of tumor cells. Such a dual target effec

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Jessen, Christina, Julia K. C. Kreß, Apoorva Baluapuri, et al. "The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression." Oncogene 39, no. 44 (2020): 6841–55. http://dx.doi.org/10.1038/s41388-020-01477-8.

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AbstractThe transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to what extent melanomas rely on NRF2. Here we show that NRF2 suppresses the activity of the melanocyte lineage marker MITF in melanoma, thereby reducing the expression of pigmentation markers. Intriguingly, we furthermore identified NRF2 as key regulator of immune-modulating genes, linking oxidative stress with the induction of cyclooxygenase

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Scalvenzi, Massimiliano, Franco Palmisano, Sara Cacciapuoti, et al. "Giant Congenital Melanocytic Naevus with Proliferative Nodules Mimicking Congenital Malignant Melanoma: A Case Report and Review of the Literature of Congenital Melanoma." Case Reports in Dermatological Medicine 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/473635.

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Congenital malignant melanoma (CMM) is a rare condition that is defined as malignant melanoma recognized at birth. CMM may develop in utero in one of three ways: (1) transmission by metastasis through the placenta from a mother with melanoma; (2) primary melanoma arising within a giant congenital melanocytic naevus (GCMN); (3) primaryde novocutaneous CMM arising in utero. CMM can be confused clinically and histologically with benign proliferative melanocytic lesions such as giant congenital nevi. We describe the case of a patient presenting a GCMN with proliferative nodules, clinically and der

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D’Arcangelo, Daniela, Francesca Scatozza, Claudia Giampietri, Paolo Marchetti, Francesco Facchiano, and Antonio Facchiano. "Ion Channel Expression in Human Melanoma Samples: In Silico Identification and Experimental Validation of Molecular Targets." Cancers 11, no. 4 (2019): 446. http://dx.doi.org/10.3390/cancers11040446.

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Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p < 0.05) differential expression in melanoma- vs. nevi-biopsies, taken from the GEO database. ROC (receiver operating characteristic) analysis selected 20 genes as potential markers showing the highest discrimination ability of melanoma vs. nevi (AUC > 0.90 and p < 0.0001). These 20 genes underwent a first in silico-validation round in an independent patients-dataset from GEO. A second-in

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Pejkova, Sofija, Gjorgje Dzokic, Smilja Tudzarova-Gjorgova, and Sasho Panov. "Molecular Biology and Genetic Mechanisms in the Progression of the Malignant Skin Melanoma." PRILOZI 37, no. 2-3 (2016): 89–97. http://dx.doi.org/10.1515/prilozi-2016-0021.

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Abstract Malignant skin melanoma is a tumor deriving from transformed skin melanocytes as a result of complex interactions between genetic and environmental factors. This melanoma has a potential to metastasize early and very often it is resistant to the existing modalities of the systemic therapy. As in any other neoplasms, certain types of melanoma may skip certain stages of progression. The progression from one stage to another is accompanied by specific biological changes. Several key changes in the melanoma tumorogenesis influence the regulation of the cell proliferation and vitality, inc

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Leo, Angela, Erica Pranzini, Laura Pietrovito, et al. "Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells." Cancers 13, no. 14 (2021): 3551. http://dx.doi.org/10.3390/cancers13143551.

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Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, melanoma cells are able to migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type motility and the elongated/mesenchymal-type motility. In particular, the amoeboid motility strongly contributes to the dissemination of highly invasive melanoma cells and no treatment targeting this process is currently available for clinical application. Here, we tested Claisened Hexafluoro as a novel inhibitor of the amoeboid motility. Reported data demonstrate

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Sood, Siddhartha, Rahul Jayachandiran, and Siyaram Pandey. "Current Advancements and Novel Strategies in the Treatment of Metastatic Melanoma." Integrative Cancer Therapies 20 (January 2021): 153473542199007. http://dx.doi.org/10.1177/1534735421990078.

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Melanoma is the deadliest form of skin cancer in the world with a growing incidence in North America. Contemporary treatments for melanoma include surgical resection, chemotherapy, and radiotherapy. However, apart from resection in early melanoma, the prognosis of patients using these treatments is typically poor. In the past decade, there have been significant advancements in melanoma therapies. Immunotherapies such as ipilimumab and targeted therapies such as vemurafenib have emerged as a promising option for patients as seen in both scientific and clinical research. Furthermore, combination

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Chernysheva, Markina, Demidov, et al. "Bone Marrow Involvement in Melanoma. Potentials for Detection of Disseminated Tumor Cells and Characterization of Their Subsets by Flow Cytometry." Cells 8, no. 6 (2019): 627. http://dx.doi.org/10.3390/cells8060627.

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Disseminated tumor cells (DTCs) are studied as a prognostic factor in many non-hematopoietic tumors. Melanoma is one of the most aggressive tumors. Forty percent of melanoma patients develop distant metastases at five or more years after curative surgery, and frequent manifestations of melanoma without an identified primary lesion may reflect the tendency of melanoma cells to spread from indolent sites such as bone marrow (BM). The purpose of this work was to evaluate the possibility of detecting melanoma DTCs in BM based on the expression of a cytoplasmatic premelanocytic glycoprotein HMB-45

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Kim, Geon-Hee, Xue-Quan Fang, Woo-Jin Lim, et al. "Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1." International Journal of Molecular Sciences 21, no. 18 (2020): 6706. http://dx.doi.org/10.3390/ijms21186706.

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Constitutive activation of the β-catenin dependent canonical Wnt signaling pathway, which enhances tumor growth and progression in multiple types of cancer, is commonly observed in melanoma. LEF1 activates β-catenin/TCF4 transcriptional activity, promoting tumor growth and progression. Although several reports have shown that LEF1 is highly expressed in melanoma, the functional role of LEF1 in melanoma growth is not fully understood. While A375, A2058, and G361 melanoma cells exhibit abnormally high LEF1 expression, lung cancer cells express lower LEF1 levels. A luciferase assay-based high thr

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Muralidharan, Somsundar Veppil, Berglind Osk Einarsdottir, Joydeep Bhadury, et al. "BET bromodomain inhibitors synergize with ATR inhibitors in melanoma." Cell Death & Disease 8, no. 8 (2017): e2982-e2982. http://dx.doi.org/10.1038/cddis.2017.383.

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Abstract Metastatic malignant melanoma continues to be a challenging disease despite clinical translation of the comprehensive understanding of driver mutations and how melanoma cells evade immune attack. In Myc-driven lymphoma, efficacy of epigenetic inhibitors of the bromodomain and extra-terminal domain (BET) family of bromodomain proteins can be enhanced by combination therapy with inhibitors of the DNA damage response kinase ATR. Whether this combination is active in solid malignancies like melanoma, and how it relates to immune therapy, has not previously investigated. To test efficacy a

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Kwan, Hiu Yee, Xiuqiong Fu, Bin Liu, et al. "Subcutaneous Adipocytes Promote Melanoma Cell Growth by Activating the Akt Signaling Pathway." Journal of Biological Chemistry 289, no. 44 (2014): 30525–37. http://dx.doi.org/10.1074/jbc.m114.593210.

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Tumorigenesis involves constant communication between tumor cells and neighboring normal cells such as adipocytes. The canonical function of adipocytes is to store triglyceride and release fatty acids for other tissues. This study was aimed to find out if adipocytes promoted melanoma cell growth and to investigate the underlying mechanism. Here we isolated adipocytes from inguinal adipose tissue in mice and co-cultured with melanoma cells. We found that the co-cultured melanoma had higher lipid accumulation compared with mono-cultured melanoma. In addition, fluorescently labeled fatty acid BOD

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Tran, Khanh B., Christina M. Buchanan, and Peter R. Shepherd. "Evolution of Molecular Targets in Melanoma Treatment." Current Pharmaceutical Design 26, no. 4 (2020): 396–414. http://dx.doi.org/10.2174/1381612826666200130091318.

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Melanoma is the deadliest type of skin cancers, accounting for more than 80% of skin cancer mortality. Although melanoma was known very early in the history of medicine, treatment for this disease had remained largely the same until very recently. Previous treatment options, including removal surgery and systemic chemotherapy, offered little benefit in extending the survival of melanoma patients. However, the last decade has seen breakthroughs in melanoma treatment, which all emerged following new insight into the oncogenic signaling of melanoma. This paper reviewed the evolution of drug targe

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Ene, Corina-Daniela, Amalia-Elena Anghel, Monica Neagu, and Ilinca Nicolae. "25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression." Mediators of Inflammation 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/904876.

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Background. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, s

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Svoboda, Ryan M., Abigail I. Franco, and Darrell S. Rigel. "Electrical Impedance Spectroscopy Versus Clinical Inspection Approaches: Melanoma Efficacy Detection Comparison." SKIN The Journal of Cutaneous Medicine 2, no. 3 (2018): 162–67. http://dx.doi.org/10.25251/skin.2.3.2.

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Early detection of melanoma continues to provide a diagnostic challenge for Dermatologists and other healthcare providers. Recently, there has been increased interest in the use of novel technology to aid in the detection of melanoma. We retrospectively compared the results of one such technology—electrical impedance spectroscopy (EIS)—to existing melanoma detection tools in 265 cases of malignant melanoma. Lesions were analyzed using EIS, the clinical ABCD rule, the ABCD dermoscopy rule, and the standard and weighted melanoma 7-point checklists. The proportion of false negative cases was calc

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Čelakovská, Jarmila, Josef Bukač, Lenka Čáková, Marie Šimková, and Eva Jandová. "Melanoma Incidence in Czech Republic, the Relation between Histology, Body Site of Melanoma, and Duration of Lesions." Acta Medica (Hradec Kralove, Czech Republic) 63, no. 1 (2020): 1–9. http://dx.doi.org/10.14712/18059694.2020.9.

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Aim: To evaluate the occurrence of melanoma in the period 1996–2017 in East Bohemia region in the Czech Republic. Method: We studied the incidence of melanoma and the age of diagnosis (adjusted calculation) and the parameters such as histology, body site of lesions, the length of the duration of lesions in 2810 patients. Results and conclusion: No change in the occurrence of melanoma and in age of melanoma during this period was found. The difference between men and women was not confirmed in histology, but the difference between men and women was confirmed in the body site of lesion and in th

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Sanzo, M., R. Colucci, M. Arunachalam, S. Berti, and S. Moretti. "Stress as a Possible Mechanism in Melanoma Progression." Dermatology Research and Practice 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/483493.

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The incidence of melanoma, the most aggressive type of cutaneous malignant tumor, is currently on the rise. Treatment in advanced stages is still unsuccessful compared with other malignant tumors, thus it is important to indentify the key mechanisms responsible for melanoma progression and metastasis. Genetic and molecular components, in particular, that are up- or downregulated in melanoma cells, affect the invasive potential of melanoma. Another possible important cofactor highlighted by recent studies is chronic stress, involving environmental and psychological factors, which can be an impo

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Carbone, Maria Luigia, Pedro Miguel Lacal, Serena Messinese, et al. "Multiple Sclerosis Treatment and Melanoma Development." International Journal of Molecular Sciences 21, no. 8 (2020): 2950. http://dx.doi.org/10.3390/ijms21082950.

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Therapy of multiple sclerosis (MS) with disease-modifying agents such as natalizumab or fingolimod has been associated with the development of cutaneous melanoma. Here we briefly revise literature data and report of a case of a 48-year old woman who developed a melanoma and several atypical naevi after sub sequential treatment with natalizumab (1 year) and fingolimod (7 years). By immunohistochemistry we observed the presence of T cells and leukocyte infiltration as well as of vascular endothelial growth factor (VEGF)-A expression in the patient melanoma biopsy. Then, we analyzed proliferation

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Fonti, Rosa, Sara Pellegrino, Ciro Gabriele Mainolfi, Elide Matano, and Silvana Del Vecchio. "Brain Metastases Unresponsive to Immunotherapy Detected by 18F-FDG-PET/CT in a Patient with Melanoma." Diagnostics 10, no. 6 (2020): 410. http://dx.doi.org/10.3390/diagnostics10060410.

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Recently, newer therapies such as immunotherapy have been increasingly used in the treatment of several tumors, including advanced melanoma. In particular, several studies showed that the combination of ipilimumab, an anti-Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) monoclonal antibody and nivolumab, an anti-Programmed Death 1 (PD-1) monoclonal antibody, leads to improved survival in patients with metastatic melanoma. Despite that, immunotherapeutic agents may not reach therapeutic concentration in the brain due to the blood–brain barrier. We report the case of a 50-year-old man with

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Göppner, Daniela, and Martin Leverkus. "Prognostic Parameters for the Primary Care of Melanoma Patients: What Is Really Risky in Melanoma?" Journal of Skin Cancer 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/521947.

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Due to intensified research in recent years, the understanding of the molecular mechanisms involved in the development of melanoma has dramatically improved. The discovery of specific, causal mutations such as BRAF or KIT oncogenes not only renders a targeted and thus more effective therapeutic approach possible, but also gives rise to a new genetic-based classification. Targeting just a few out of several potential mutations, BRAF-Inhibitors such as PLX 4032 achieved already tremendous results in the therapy of metastatic melanoma. Up to now, the correlation of clinical, histomorphologic, and

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Muralikrishnan, Sivraj, Lara K. Ronan, Shodeinde Coker, Paula K. Rauschkolb, and Keisuke Shirai. "Treatment Considerations for Patients with Unresectable Metastatic Melanoma Who Develop Pembrolizumab-Induced Guillain-Barré Toxicity: A Case Report." Case Reports in Oncology 13, no. 1 (2020): 43–48. http://dx.doi.org/10.1159/000504930.

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Immunotherapy has improved outcomes in many malignancies, most notably in melanoma, lung cancer, and bladder cancer. Understanding the side effects associated with these medications is an important part of managing our patients. Although fatigue, rash, and diarrhea are commonly reported side effects, it is important to be cognizant of rarer ones, such as neuropathy. Amongst the different neurological toxicities that have been reported in the literature, Guillain-Barré-like neuropathies are quite rare. However, the occurrence of such neuropathies in a patient can be life threatening. The proble

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Marra, Antonio, Giosuè Scognamiglio, Ilaria Peluso, et al. "Immune Checkpoint Inhibitors in Melanoma and HIV Infection." Open AIDS Journal 11, no. 1 (2017): 91–100. http://dx.doi.org/10.2174/1874613601711010091.

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Introduction:Immunotherapy with immune checkpoint inhibitors increases the overall survival of patients with metastatic melanoma regardless of their oncogene addicted mutations. However, no data is available from clinical trials of effective therapies in subgroups of melanoma patients that carry chronic infective diseases such as HIV. Evidences suggest a key role of the immune checkpoint molecules as a mechanism of immune escape not only from melanoma but also from HIV host immune response.Conclusion:In this article, firstly, we will describe the role of the immune checkpoint molecules in HIV

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