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Journal articles on the topic 'Sucrose Non-Fermentable'

Author: Grafiati
Published: 16 November 2024
Last updated: 31 July 2025

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1

Hargono, Hargono, Bakti Jos, Abdullah Abdullah, and Teguh Riyanto. "Inhibition Effect of Ca2+ Ions on Sucrose Hydrolysis Using Invertase." Bulletin of Chemical Reaction Engineering & Catalysis 14, no. 3 (2019): 646. http://dx.doi.org/10.9767/bcrec.14.3.4437.646-653.

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Fermentable sugar for bioethanol production can be produced from molasses due to its high sucrose content but Ca2+ ions found in the molasses may affect the hydrolysis. Therefore, this paper was focused to study the effect of Ca2+ ions as CaO on sucrose hydrolysis using invertase and to obtain the kinetic parameters. The kinetic parameters (KM and Vmax) were obtained using a Lineweaver-Burk plot. The value of KM and Vmax parameters were 36.181 g/L and 21.322 g/L.h, respectively. The Ca2+ ions act as competitive inhibitor in sucrose hydrolysis using invertase. Therefore, the inhibition mechanis
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2

Bajaj, Anubha. "Exiguous and Scarce-SMARCB1 Deficient Medullary Renal Cell Carcinoma." Cell & Cellular Life Sciences Journal 8, no. 2 (2023): 1–4. http://dx.doi.org/10.23880/cclsj-16000188.

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Switch / sucrose non fermentable (SWI/SNF) related, matrix associated, actin dependent regulator of chromatin subfamily B member 1 (SMARCB1) deficient medullary renal cell carcinoma is an exceptionally discerned, aggressive carcinoma associated with deficiency of SMARCB1 or integrase interactor 1(INI1).
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3

Choi, Sung Kyung, Myoung Jun Kim, and Jueng Soo You. "SMARCB1 Acts as a Quiescent Gatekeeper for Cell Cycle and Immune Response in Human Cells." International Journal of Molecular Sciences 21, no. 11 (2020): 3969. http://dx.doi.org/10.3390/ijms21113969.

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Switch/sucrose non-fermentable (SWI/SNF)-related matrix-associated actin-dependent regulator of chromatin (SMARC) subfamily B member 1 (SMARCB1) is a core subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, one of the adenosine triphosphate (ATP)-dependent chromatin remodeler complexes. The unique role of SMARCB1 has been reported in various cellular contexts. Here, we focused on the general role of the ubiquitous expression of SMARCB1 in a normal cell state. We selected ARPE19 (human primary retinal pigment epithelium) and IMR90 (from human fetal lung fibroblasts) cell lines as t
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4

Roberts, Michael, and J. Timothy Wright. "Food sugar substitutes: a brief review for dental clinicians." Journal of Clinical Pediatric Dentistry 27, no. 1 (2003): 1–4. http://dx.doi.org/10.17796/jcpd.27.1.bl98u70371655hp8.

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The frequent ingestion of fermentable sugars such as sucrose, fructose, glucose and maltose is conducive to the development of caries in the teeth of susceptible individuals. Natural and artificial alternatives to these sugars have been and continue to be developed as non/low-caloric sweeteners. The US Food and Drug Administration have approved four non-caloric sweeteners at present. However, there are several other non-caloric sweeteners being commonly used in other countries.A review of these sweeteners is provided with information on a promising new agent that has not yet gained FDA approva
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Younas, Samavia, Asma Chaudhary, Esha Rehman, Bushra Bilal, Ayesha Aihetasham, and Syeda Anjum Tahira. "Statistical sucrolytic modeling for cane molasses-based ethanol optimization." Zoo Botanica 2, no. 3 (2025): 229–39. https://doi.org/10.55627/zoobotanica.002.03.1007.

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To manage waste and address energy crises, the current study focuses on the concept of "Energy from waste. Molasses, a byproduct in sugar synthesis process, is one of the most prevalent types of organic waste. Due to excessive production and use in distilleries in Pakistan, the non-fermentable portion is drained in spent wash, and it is creating serious environmental problems viz soil acidification, manganese deficiency and inhibit seed germination. Effective conversion of non-fermentable sucrose portion of black strap molasses to bioethanol is the main purpose of this study. Bacillus cereus F
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Dobrescu, Andreea Cristina, Henrique César Teixeira Veras, Cristiano Varrone, and Jan Dines Knudsen. "Novel Propagation Strategy of Saccharomyces cerevisiae for Enhanced Xylose Metabolism during Fermentation on Softwood Hydrolysate." Fermentation 7, no. 4 (2021): 288. http://dx.doi.org/10.3390/fermentation7040288.

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An economically viable production of second-generation bioethanol by recombinant xylose-fermenting Saccharomyces cerevisiae requires higher xylose fermentation rates and improved glucose–xylose co-consumption. Moreover, xylose-fermenting S. cerevisiae recognises xylose as a non-fermentable rather than a fermentable carbon source, which might partly explain why xylose is not fermented into ethanol as efficiently as glucose. This study proposes propagating S. cerevisiae on non-fermentable carbon sources to enhance xylose metabolism during fermentation. When compared to yeast grown on sucrose, ce
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7

Kakar, Smita, Xianyang Fang, Lucyna Lubkowska, et al. "Allosteric Activation of Bacterial Swi2/Snf2 (Switch/Sucrose Non-fermentable) Protein RapA by RNA Polymerase." Journal of Biological Chemistry 290, no. 39 (2015): 23656–69. http://dx.doi.org/10.1074/jbc.m114.618801.

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8

Roberts, Michael W., and J. Timothy Wright. "Nonnutritive, Low Caloric Substitutes for Food Sugars: Clinical Implications for Addressing the Incidence of Dental Caries and Overweight/Obesity." International Journal of Dentistry 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/625701.

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Caries and obesity are two common conditions affecting children in the United States and other developed countries. Caries in the teeth of susceptible children have often been associated with frequent ingestion of fermentable sugars such as sucrose, fructose, glucose, and maltose. Increased calorie intake associated with sugars and carbohydrates, especially when associated with physical inactivity, has been implicated in childhood obesity. Fortunately, nonnutritive artificial alternatives and non-/low-caloric natural sugars have been developed as alternatives to fermentable sugars and have sho
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9

Moelich, Nadine, Nicoline Potgieter, Francien S. Botha, James Wesley-Smith, and Candice Van Wyk. "The search for a healthy sugar substitute in aid to lower the incidence of Early Childhood Caries: a comparison of sucrose, xylitol, erythritol and stevia." South African Dental Journal 77, no. 08 (2022): 465–71. http://dx.doi.org/10.17159/2519-0105/2022/v77no8a2.

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A pursuit to find a healthy alternative to sucrose with less cariogenic potential, which can potentially lower the incidence of Early Childhood Caries (ECC), by means of comparison. Primary tooth enamel blocks (n=32) were randomly divided into four groups and exposed to 5% concentrations of the respective test groups (sucrose, xylitol, erythritol and stevia). All samples were inoculated with S. mutans standard strain (ATCC 25175) at room temperature. Analysis of Colony Forming Units (CFUs), acidity measurements (pH) and Scanning Electron Microscopy (SEM) observations were done after 6, 12, 18
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10

Del Savio, Elisa, and Roberta Maestro. "Beyond SMARCB1 Loss: Recent Insights into the Pathobiology of Epithelioid Sarcoma." Cells 11, no. 17 (2022): 2626. http://dx.doi.org/10.3390/cells11172626.

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Epithelioid sarcoma (ES) is a very rare and aggressive mesenchymal tumor of unclear origin and uncertain lineage characterized by a prevalent epithelioid morphology. The only recurrent genetic alteration reported in ES as yet is the functional inactivation of SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), a key component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complexes. How SMARCB1 deficiency dictates the clinicopathological characteristics of ES and what other molecular defects concur to its malignant prog
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11

Liu, Hongyu, Yang Zhao, Guizhen Zhao, Yongjie Deng, Y. Eugene Chen, and Jifeng Zhang. "SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies." Cells 13, no. 2 (2024): 168. http://dx.doi.org/10.3390/cells13020168.

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Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic
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12

Nguyen, Thinh T., Joanne G. A. Savory, Travis Brooke-Bisschop, et al. "Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity." Journal of Biological Chemistry 292, no. 8 (2017): 3389–99. http://dx.doi.org/10.1074/jbc.m116.752774.

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The packaging of genomic DNA into nucleosomes creates a barrier to transcription that can be relieved through ATP-dependent chromatin remodeling via complexes such as the switch-sucrose non-fermentable (SWI-SNF) chromatin remodeling complex. The SWI-SNF complex remodels chromatin via conformational or positional changes of nucleosomes, thereby altering the access of transcriptional machinery to target genes. The SWI-SNF complex has limited ability to bind to sequence-specific elements, and, therefore, its recruitment to target loci is believed to require interaction with DNA-associated transcr
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13

Rembiałkowska, Nina, Katarzyna Rekiel, Piotr Urbanowicz, et al. "Epigenetic Dysregulation in Cancer: Implications for Gene Expression and DNA Repair-Associated Pathways." International Journal of Molecular Sciences 26, no. 13 (2025): 6531. https://doi.org/10.3390/ijms26136531.

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Epigenetic modifications are heritable, reversible alterations that causally reshape chromatin architecture and thereby influence DNA repair without changing nucleotide sequence. DNA methylation, histone modifications and non-coding RNAs profoundly influence DNA repair mechanisms and genomic stability. Aberrant epigenetic patterns in cancer compromise DNA damage recognition and repair, therefore impairing homologous recombination (HR), non-homologous end joining (NHEJ), and base excision repair (BER) by suppressing key repair genes and lowering access to repair sites. Then it is dissected how
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14

Wanior, Marek, Andreas Krämer, Stefan Knapp, and Andreas C. Joerger. "Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy." Oncogene 40, no. 21 (2021): 3637–54. http://dx.doi.org/10.1038/s41388-021-01781-x.

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AbstractMulti-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequently driving oncogenic programmes. Some SWI/SNF-mutant cancers are hypersensitive to perturbations in other SWI/SNF subunits, regulatory proteins and distinct biological pathways, often resulting in sustained anticancer effects and synthetic lethal interactions. Exploiting these vulnerabilitie
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15

Soto-Castillo, Juan José, Lucía Llavata-Marti, Roser Fort-Culillas, et al. "SWI/SNF Complex Alterations in Tumors with Rhabdoid Features: Novel Therapeutic Approaches and Opportunities for Adoptive Cell Therapy." International Journal of Molecular Sciences 24, no. 13 (2023): 11143. http://dx.doi.org/10.3390/ijms241311143.

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The SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex is one of the most remarkably altered epigenetic regulators in cancer. Pathogenic mutations in genes encoding SWI/SNF-related proteins have been recently described in many solid tumors, including rare and aggressive malignancies with rhabdoid features with no standard therapies in advanced or metastatic settings. In recent years, clinical trials with targeted drugs aimed at restoring its function have shown discouraging results. However, preclinical data have found an association between these epigenetic alterations and
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16

Moreira, B. R. A., R. S. Viana, L. A. M. Lisboa, et al. "Jasmonic Acid and K-Phosphite Enhance Productivity and Technological Quality of Sugarcane Crop." Journal of Agricultural Science 11, no. 14 (2019): 254. http://dx.doi.org/10.5539/jas.v11n14p254.

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Plant resistance inducers are cost-effective and environmentally pleasing strategies of plant protection to mitigate biotic and abiotic agents threatening food safety and energy security. We, accordingly, present jasmonic acid and k-phosphite as low-cost strategies to enhance productive yield and technological quality of sugarcane crop. Exogenously treatment of the sugarcane variety ‘SP81-3250’ consisted of carrying out foliar application of jasmonic acid at 1, 1.5 and 2 ml L-1 and K-phosphite at 2, 4 and 6 ml L-1 before crop flowering. Interestingly, both systemic phytorre
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17

Collingwood, TN, FD Urnov, and AP Wolffe. "Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription." Journal of Molecular Endocrinology 23, no. 3 (1999): 255–75. http://dx.doi.org/10.1677/jme.0.0230255.

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A contemporary view of hormone action at the transcriptional level requires knowledge of the transcription factors including the hormone receptor that may bind to promoters or enhancers, together with the chromosomal context within which these regulatory proteins function. Nuclear receptors provide the best examples of transcriptional control through the targeted recruitment of large protein complexes that modify chromosomal components and reversibly stabilize or destabilize chromatin. Ligand-dependent recruitment of transcriptional coactivators destabilizes chromatin by mechanisms including h
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18

Parfenov, Asfold I. "The value of increased intestinal permeability in the pathogenesis of internal diseases." Terapevticheskii arkhiv 96, no. 2 (2024): 85–90. http://dx.doi.org/10.26442/00403660.2024.02.202587.

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In the process of evolution in the gastrointestinal tract, a system of protection against bacterial and food antigens from getting into the blood was formed. The causes of increased intestinal permeability (IIP) can be microbiota imbalance, use of antibiotics, non-steroidal anti-inflammatory drugs, stress, diet rich in fructose, glucose, sucrose and long-chain fatty acids. The appearance of IIP may be of paramount importance in the pathogenesis of autoimmune diseases. A diet low in fermentable oligodimonosaccharides and polyols, pre- and probiotics, polyphenols, vitamins, short-chain fatty aci
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19

Cruz-Tapia, Roberto Onner, Ana María Cano-Valdez, Abelardo Meneses-García, et al. "Switch/Sucrose Non-Fermentable (SWI/SNF) Complex—Partial Loss in Sinonasal Squamous Cell Carcinoma: A High-Grade Morphology Impact and Progression." Current Issues in Molecular Biology 46, no. 11 (2024): 12183–95. http://dx.doi.org/10.3390/cimb46110723.

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Sinonasal carcinomas are aggressive neoplasms that present a high morbidity and mortality rate with an unfavorable prognosis. This group of tumors exhibits morphological and genetic diversity. Genetic and epigenetic alterations in these neoplasms are the current targets for diagnosis and treatment. The most common type of cancer originating in the sinonasal tract is sinonasal squamous cell carcinomas (SNSCCs), which present different histological patterns and variable histological aggressiveness. A significant number of alterations have been reported in sinonasal tumors, including deficiencies
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20

Ngo, Carine, and Sophie Postel-Vinay. "Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments." Biomedicines 10, no. 3 (2022): 650. http://dx.doi.org/10.3390/biomedicines10030650.

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Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) complex occur in 20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently mutated, and SMARCB1 loss represents a founder driver event in several malignancies, such as malignant rhabdoid tumors (MRT), epithelioid sarcoma, poorly differentiated chordoma, and renal medullary carcinoma (RMC). Intriguingly, SMARCB1-deficient pediatric MRT and RMC have recently been reported to be immunogenic, despite their very simple genome and low tumor mutational burden. Responses to immune checkpoint inhibitors ha
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21

Padilla-Benavides, Teresita, Pablo Reyes-Gutierrez, and Anthony N. Imbalzano. "Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis." Biology 9, no. 7 (2020): 152. http://dx.doi.org/10.3390/biology9070152.

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Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and activation of transcription factors. Chromatin remodeling enzymes utilize ATP hydrolysis to alter nucleosome structure and/or positioning. The mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) family of chromatin remodeling enzymes is essential for myogenesis. Here we review diverse and novel mechanisms of regulation of mSWI/SNF enzymes by kin
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22

Hasan, Nesrin, and Nita Ahuja. "The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer." Cancers 11, no. 12 (2019): 1859. http://dx.doi.org/10.3390/cancers11121859.

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Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic dysregulation has been associated with the initiation and progression of pancreatic tumors. Multiple studies have pointed to the involvement of aberrant chromatin modifications in driving tumor behavior. ATP-dependent chromatin remodeling complexes regulate chromatin structure and have critical roles in stem cell maintenance, development, and cancer. Frequent mutations and chromosomal aberrations in the genes associated with subunits of the ATP-dependent chromatin remodeling complexes have been detected i
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23

Wu, Shuai, Nail Fatkhutdinov, Leah Rosin, et al. "ARID1A spatially partitions interphase chromosomes." Science Advances 5, no. 5 (2019): eaaw5294. http://dx.doi.org/10.1126/sciadv.aaw5294.

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ARID1A, a subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex, localizes to both promoters and enhancers to influence transcription. However, the role of ARID1A in higher-order spatial chromosome partitioning and genome organization is unknown. Here, we show that ARID1A spatially partitions interphase chromosomes and regulates higher-order genome organization. The SWI/SNF complex interacts with condensin II, and they display significant colocalizations at enhancers. ARID1A knockout drives the redistribution of condensin II preferentially at enhancers, which pos
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24

Luo, Qingyu, Xiaowei Wu, Wan Chang, et al. "ARID1A Hypermethylation Disrupts Transcriptional Homeostasis to Promote Squamous Cell Carcinoma Progression." Cancer Research 80, no. 3 (2020): 406–17. http://dx.doi.org/10.1158/0008-5472.can-18-2446.

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Abstract Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complexes have a mutation rate of approximately 20% in human cancer, and ARID1A is the most frequently mutated component. However, some components of SWI/SNF complexes, including ARID1A, exhibit a very low mutation rate in squamous cell carcinoma (SCC), and their role in SCC remains unknown. Here, we demonstrate that the low expression of ARID1A in SCC is the result of promoter hypermethylation. Low levels of ARID1A were associated with a poor prognosis. ARID1A maintained transcriptional homeostasis through both direct and
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25

Hu, Xiaolong, Mengjie Li, Xue Hao, Yi Lu, Lei Zhang, and Geng Wu. "The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation." Genes 12, no. 3 (2021): 363. http://dx.doi.org/10.3390/genes12030363.

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The Drosophila ovary is recognized as a powerful model to study stem cell self-renewal and differentiation. Decapentaplegic (Dpp) is secreted from the germline stem cell (GSC) niche to activate Bone Morphogenic Protein (BMP) signaling in GSCs for their self-renewal and is restricted in the differentiation niche for daughter cell differentiation. Here, we report that Switch/sucrose non-fermentable (SWI/SNF) component Osa depletion in escort cells (ECs) results in a blockage of GSC progeny differentiation. Further molecular and genetic analyses suggest that the defective germline differentiation
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Li, Jing Jing, and Cheok Soon Lee. "The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis." Genes 15, no. 1 (2023): 5. http://dx.doi.org/10.3390/genes15010005.

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The switch/sucrose non-fermentable (SWI/SNF) (SWI/SNF) complex uses energy from ATP hydrolysis to mobilise nucleosomes on chromatin. Components of SWI/SNF are mutated in 20% of all human cancers, of which mutations in AT-rich binding domain protein 1A (ARID1A) are the most common. ARID1A is mutated in nearly half of ovarian clear cell carcinoma and around one-third of endometrial and ovarian carcinomas of the endometrioid type. This review will examine in detail the molecular functions of ARID1A, including its role in cell cycle control, enhancer regulation, and the prevention of telomerase ac
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27

Salli, Krista, Markus J. Lehtinen, Kirsti Tiihonen, and Arthur C. Ouwehand. "Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review." Nutrients 11, no. 8 (2019): 1813. http://dx.doi.org/10.3390/nu11081813.

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Xylitol has been widely documented to have dental health benefits, such as reducing the risk for dental caries. Here we report on other health benefits that have been investigated for xylitol. In skin, xylitol has been reported to improve barrier function and suppress the growth of potential skin pathogens. As a non-digestible carbohydrate, xylitol enters the colon where it is fermented by members of the colonic microbiota; species of the genus Anaerostipes have been reported to ferment xylitol and produce butyrate. The most common Lactobacillus and Bifidobacterium species do not appear to be
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Xiao, Lanbo, Abhijit Parolia, Yuanyuan Qiao, et al. "Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer." Nature 601, no. 7893 (2021): 434–39. http://dx.doi.org/10.1038/s41586-021-04246-z.

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AbstractThe switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. Androgen receptor (AR)+ forkhead box A1 (FOXA1)+ prostate cancer cells are exquisitely sensitive to dual SMARCA2 and SMARCA4 degradation relative to normal and other cancer cell lines. SWI/SNF ATPase degradation rapidly compacts cis-regulatory elements bound by transcription factors that drive prostate cancer cel
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El Hadidy and Uversky. "Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development." International Journal of Molecular Sciences 20, no. 21 (2019): 5260. http://dx.doi.org/10.3390/ijms20215260.

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The two-meter-long DNA is compressed into chromatin in the nucleus of every cell, which serves as a significant barrier to transcription. Therefore, for processes such as replication and transcription to occur, the highly compacted chromatin must be relaxed, and the processes required for chromatin reorganization for the aim of replication or transcription are controlled by ATP-dependent nucleosome remodelers. One of the most highly studied remodelers of this kind is the BRG1- or BRM-associated factor complex (BAF complex, also known as SWItch/sucrose non-fermentable (SWI/SNF) complex), which
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Reske, Jake J., Mike R. Wilson, Jeanne Holladay, Marc Wegener, Marie Adams, and Ronald L. Chandler. "SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity." Human Molecular Genetics 29, no. 20 (2020): 3412–30. http://dx.doi.org/10.1093/hmg/ddaa227.

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Abstract Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related gene 1 (BRG1, SMARCA4), the SWI/SNF catalytic subunit, in the endometrial epithelium. BRG1 loss affects more than one-third of all active genes and highly overlaps with the ARID1A gene regulatory network. Chromatin immunoprecipitation studies revealed widespread subunit-specific differences in transcriptional regulation, as BRG1 promoter interactions
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Kang, Jong-Seol, Dongha Kim, Joonwoo Rhee, et al. "Baf155 regulates skeletal muscle metabolism via HIF-1a signaling." PLOS Biology 21, no. 7 (2023): e3002192. http://dx.doi.org/10.1371/journal.pbio.3002192.

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During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) is stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using a skeletal muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated factor 155 (Baf155), a core subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, is essential for HIF-1α signaling in skeletal muscle. Muscle-specific ablation of Baf155 increases oxidative metabolism by reducing HIF-1α function, which acco
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Mat Ali, N. N., F. I. Abu Bakar, M. F. Abu Bakar, et al. "The effect of soursop as fermentable substrate in formulating flavoured water kefir beverage." Food Research 8, Supplementary 5 (2024): 20–25. http://dx.doi.org/10.26656/fr.2017.8(s5).4.

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Water kefir is a fermented sucrose solution from fruits or vegetable juices that produces acidic fermented beverages. This study aimed to explore the usage of soursop pulp as a fermentable substrate to formulate a non-dairy fermented beverage. In this study, fruit juice from soursop was fermented with water kefir grains for 48 hrs at 24°C. The first fermentation of sugary water with water kefir grains was carried out for four days and the second fermentation of the fermented water with soursop juice was carried out for two days at room temperature. The beverage formulations based on soursop co
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Lu, Ping, Si-Yu Dai, Ling-Tao Yong, et al. "A Soybean Sucrose Non-Fermenting Protein Kinase 1 Gene, GmSNF1, Positively Regulates Plant Response to Salt and Salt–Alkali Stress in Transgenic Plants." International Journal of Molecular Sciences 24, no. 15 (2023): 12482. http://dx.doi.org/10.3390/ijms241512482.

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Soybean is one of the most widely grown oilseed crops worldwide. Several unfavorable factors, including salt and salt–alkali stress caused by soil salinization, affect soybean yield and quality. Therefore, exploring the molecular basis of salt tolerance in plants and developing genetic resources for genetic breeding is important. Sucrose non-fermentable protein kinase 1 (SnRK1) belongs to a class of Ser/Thr protein kinases that are evolutionarily highly conserved direct homologs of yeast SNF1 and animal AMPKs and are involved in various abiotic stresses in plants. The GmPKS4 gene was experimen
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Crodian, Jennifer S., Bethany M. Weldon, Yu-Chun Tseng, Birgit Cabot, and Ryan Cabot. "Nuclear trafficking dynamics of Bromodomain-containing protein 7 (BRD7), a switch/sucrose non-fermentable (SWI/SNF) chromatin remodelling complex subunit, in porcine oocytes and cleavage-stage embryos." Reproduction, Fertility and Development 31, no. 9 (2019): 1497. http://dx.doi.org/10.1071/rd19030.

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In the work presented here, we investigated how bromodomain-containing protein 7 (BRD7), a subunit associated with switch/sucrose non-fermentable (SWI/SNF) chromatin remodelling complexes, is trafficked between cellular compartments during embryo development. SWI/SNF complexes are multi-subunit complexes that contain a core catalytic subunit (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4, or member 2; SMARCA4 or SMARCA2) and a collection of additional subunits that guide the complexes to their appropriate loci; BRD7 is one of these additional
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Keim, Juan P., Mónica Gandarillas, Daniel Benavides, et al. "Nutrient concentrations and profile of non-structural carbohydrates vary among different Brassica forages." Animal Production Science 60, no. 12 (2020): 1503. http://dx.doi.org/10.1071/an19472.

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Context Brassica forages are used in times of seasonal shortage to fulfil nutritional requirements of beef cattle, dairy cows, sheep or pigs. Although brassicas have been reported with high concentrations of readily fermentable carbohydrate, details have not been fully described and there is little information about the non-structural carbohydrate (NSC) profiles of Brassica forages. Aim The study was designed to evaluate nutrient concentrations, as well as NSC levels and constituents, of the main Brassica forages and to determine differences among varieties. Methods Five varieties of each of t
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Ma, Yue, Natisha R. Field, Tao Xie, et al. "Aberrant SWI/SNF Complex Members Are Predominant in Rare Ovarian Malignancies—Therapeutic Vulnerabilities in Treatment-Resistant Subtypes." Cancers 16, no. 17 (2024): 3068. http://dx.doi.org/10.3390/cancers16173068.

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SWI/SNF (SWItch/Sucrose Non-Fermentable) is the most frequently mutated chromatin-remodelling complex in human malignancy, with over 20% of tumours having a mutation in a SWI/SNF complex member. Mutations in specific SWI/SNF complex members are characteristic of rare chemoresistant ovarian cancer histopathological subtypes. Somatic mutations in ARID1A, encoding one of the mutually exclusive DNA-binding subunits of SWI/SNF, occur in 42–67% of ovarian clear cell carcinomas (OCCC). The concomitant somatic or germline mutation and epigenetic silencing of the mutually exclusive ATPase subunits SMAR
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Angelico, Giuseppe, Giulio Attanasio, Lorenzo Colarossi, et al. "ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation." Cancers 16, no. 11 (2024): 2062. http://dx.doi.org/10.3390/cancers16112062.

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AT-rich interaction domain 1 (ARID1A) is a pivotal gene with a significant role in gastrointestinal tumors which encodes a protein referred to as BAF250a or SMARCF1, an integral component of the SWI/SNF (SWItch/sucrose non-fermentable) chromatin remodeling complex. This complex is instrumental in regulating gene expression by modifying the structure of chromatin to affect the accessibility of DNA. Mutations in ARID1A have been identified in various gastrointestinal cancers, including colorectal, gastric, and pancreatic cancers. These mutations have the potential to disrupt normal SWI/SNF compl
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Roth, Bodil, Mohamed Nseir, Håkan Jeppsson, Mauro D’Amato, Kristina Sundquist, and Bodil Ohlsson. "A Starch- and Sucrose-Reduced Diet Has Similar Efficiency as Low FODMAP in IBS—A Randomized Non-Inferiority Study." Nutrients 16, no. 17 (2024): 3039. http://dx.doi.org/10.3390/nu16173039.

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A diet with low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) is established treatment for irritable bowel syndrome (IBS), with well-documented efficiency. A starch- and sucrose-reduced diet (SSRD) has shown similar promising effects. The primary aim of this randomized, non-inferiority study was to test SSRD against low FODMAP and compare the responder rates (RR = ∆Total IBS-SSS ≥ −50) to a 4-week dietary intervention of either diet. Secondary aims were to estimate responders of ≥100 score and 50% reduction; effects on extraintestinal symptoms; saturation; sugar
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Ahadi, Mahsa S., Talia L. Fuchs, Adele Clarkson, et al. "Switch/sucrose‐non‐fermentable ( SWI / SNF ) complex ( SMARCA4 , SMARCA2 , INI1 / SMARCB1 )‐deficient colorectal carcinomas are strongly associated with microsatellite instability: an incidence study in 4508 colorectal carcinomas." Histopathology 80, no. 6 (2022): 906–21. http://dx.doi.org/10.1111/his.14612.

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Peinado, Paola, Alvaro Andrades, Marta Cuadros, et al. "Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models." Cancers 12, no. 12 (2020): 3712. http://dx.doi.org/10.3390/cancers12123712.

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Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead to the discovery of new therapeutic drugs. However, choosing an appropriate cancer cell line model for SWI/SNF functional studies can be challenging because SWI/SNF subunits are frequently altered in cancer by various mechanisms, including genetic alterations and post-transcriptional mechanisms. In
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Chinnaiyan, Arul M. "Abstract IA021: Targeting epigenetic regulators of oncogenic transcription factors." Cancer Research 82, no. 23_Supplement_2 (2022): IA021. http://dx.doi.org/10.1158/1538-7445.cancepi22-ia021.

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Abstract The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodeling and is altered in over 20% of cancers. We recently developed and evaluated a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. Androgen receptor (AR)+ forkhead box A1 (FOXA1)+ prostate cancer cells are exquisitely sensitive to dual SMARCA2 and SMARCA4 degradation relative to normal and other cancer cell lines. SWI/SNF ATPase degradation rapidly compacts cis-regulatory elements bound by transcription factors that drive prost
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Xu, Mingyan, Junling Zhang, Xuemei Lu, Fan Liu, Songlin Shi, and Xiaoling Deng. "MiR-199a-5p-Regulated SMARCA4 Promotes Oral Squamous Cell Carcinoma Tumorigenesis." International Journal of Molecular Sciences 24, no. 5 (2023): 4756. http://dx.doi.org/10.3390/ijms24054756.

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SWI/SNF related, matrix associated, actin-dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as BRG1), an ATPase subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, plays an important regulatory role in many cytogenetic and cytological processes during cancer development. However, the biological function and mechanism of SMARCA4 in oral squamous cell carcinoma (OSCC) remain unclear. The present study aimed to investigate the role of SMARCA4 in OSCC and its potential mechanism. Using a tissue microarray, SMARCA4 expression was found to
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Wang, Wenjia, Scott C. Friedland, Bing Guo, et al. "ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas." Gut 68, no. 7 (2018): 1245–58. http://dx.doi.org/10.1136/gutjnl-2017-315541.

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ObjectiveHere, we evaluate the contribution of AT-rich interaction domain-containing protein 1A (ARID1A), the most frequently mutated member of the SWItch/sucrose non-fermentable (SWI/SNF) complex, in pancreatic homeostasis and pancreatic ductal adenocarcinoma (PDAC) pathogenesis using mouse models.DesignMice with a targeted deletion of Arid1a in the pancreas by itself and in the context of two common genetic alterations in PDAC, Kras and p53, were followed longitudinally. Pancreases were examined and analysed for proliferation, response to injury and tumourigenesis. Cancer cell lines derived
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Stacchiotti, Silvia, and Brian Andrew Van Tine. "Synovial Sarcoma: Current Concepts and Future Perspectives." Journal of Clinical Oncology 36, no. 2 (2018): 180–87. http://dx.doi.org/10.1200/jco.2017.75.1941.

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Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX 1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most commonly affects young adults between the ages of 15 and 30 years. The resultant tumors are either monophasic (pure sarcomas), biphasic (a combination or epithelioid and sarcomatous components), or poorly differentiated. The hybrid transcription factor SS18:SSX alters SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future therapeutic opportunities. In this re
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Damaceno, Jéssica de Medeiros, Larissa de Oliveira Bispo, Cristiane De Carli, et al. "Symbiotic profile of petit suisse diet cheese with added brazilian nuts extract, Bifidobacterium bifidum and Lactobacillus paracasei." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22, no. 1 (2024): 284–96. http://dx.doi.org/10.55905/oelv22n1-016.

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Functional foods, which promise to help cure or prevent diseases, are the new trend in the powerful food market at the beginning of the 21st century. Probiotics are live microorganisms that can be added as supplements in the diet, beneficially affecting the development of the microbial flora in the gut. Prebiotics, on the other hand, are non-digestible but fermentable oligosaccharides whose function is to change the activity and composition of the intestinal microbiota with the perspective of promoting the health of the host. The Brazil nut is an oilseed, its lipid content is of good quality,
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Leng, Lingying, Lin Yang, Wenbin Tu, et al. "Abstract 4506: Discovery of potent, highly selective and orally efficacious SMARCA2 degraders." Cancer Research 84, no. 6_Supplement (2024): 4506. http://dx.doi.org/10.1158/1538-7445.am2024-4506.

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Abstract In human non-small cell lung cancer, melanoma and other types of human cancers, the mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4 is frequently mutated, which leads to inactivation of its functions. SMARCA2, a close homologous protein of SMARCA4, is an attractive synthetic lethality target for human cancers with SMARCA4 deficiency. Herein, we report the discovery and biological evaluation of potent, highly selective, orally efficacious SMARCA2 PROTAC degraders exemplified by UM-SMD-8801. UM-SMD-8801 has DC50 <10 nM and Dmax >90% against SMARCA2 and
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Ito, Taiji, Hirotaka Watanabe, Nobutake Yamamichi, et al. "Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54nrb." Biochemical Journal 411, no. 1 (2008): 201–9. http://dx.doi.org/10.1042/bj20071075.

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We report that a DBHS (Drosophila behaviour, human splicing) family protein, p54nrb, binds both BRG1 (Brahma-related gene 1) and Brm (Brahma), catalytic subunits of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, and also another core subunit of this complex, BAF60a. The N-terminal region of p54nrb is sufficient to pull-down other core subunits of the SWI/SNF complex, suggesting that p54nrb binds SWI/SNF-like complexes. PSF (polypyrimidine tract-binding protein-associated splicing factor), another DBHS family protein known to directly bind p54nrb, was also found to
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Guo, Ao, Hongling Huang, Zhexin Zhu, et al. "The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8+ T cells." Journal of Immunology 208, no. 1_Supplement (2022): 169.02. http://dx.doi.org/10.4049/jimmunol.208.supp.169.02.

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Abstract The identification of mechanisms to promote the generation of memory T cells (TMEM) has important implications for vaccination and anti-cancer immunotherapy. Using a CRISPR-based screen for negative regulators of TMEM generation in vivo, we discovered many components of the mammalian canonical SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, also called canonical Brg1/Brg-associated factor (cBAF). cBAF is essential for the differentiation of activated, naïve CD8+ T cells into T effector (TEFF) cells, and loss of cBAF promotes TMEM formation of CD8+ T cells in vivo upon infection with
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Zhao, Jiumei, Jing Zhu, Yu Tang, Kepu Zheng, and Ziwei Li. "Advances in the study of the role of high-frequency mutant subunits of the SWI/SNF complex in tumors." Frontiers in Oncology 14 (December 4, 2024). https://doi.org/10.3389/fonc.2024.1463892.

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SWI/SNF (Switch/Sucrose non-fermentable, switch/sucrose non-fermentable) chromatin remodeling complex is a macromolecular complex composed of multiple subunits. It can use the energy generated by the hydrolysis of ATP (Adenosine triphosphate) to destroy the connection between DNA and histones, achieve the breakdown of nucleosomes, and regulate gene expression. SWI/SNF complex is essential for cell proliferation and differentiation, and the abnormal function of its subunits is closely related to tumorigenesis. Among them, ARID1A, an essential non-catalytic subunit of the SWI/SNF complex, can re
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Haefliger, Simon, Olga Chervova, Christopher Davies, et al. "Epigenetic age acceleration is a distinctive trait of epithelioid sarcoma with potential therapeutic implications." GeroScience, June 16, 2024. http://dx.doi.org/10.1007/s11357-024-01156-6.

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AbstractRecently, DNA methylation clocks have been proven to be precise age predictors, and the application of these clocks in cancer tissue has revealed a global age acceleration in a majority of cancer subtypes when compared to normal tissue from the same individual. The polycomb repressor complex 2 plays a pivotal role in the aging process, and its targets have been shown to be enriched in CpG sites that gain methylation with age. This complex is further regulated by the chromatin remodeling complex SWItch/Sucrose Non-Fermentable and its core subunit, notably the tumor suppressor gene SMARC
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