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Journal articles on the topic 'Sudden sensorineural hearing loss (SSNHL)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Berg, Susan, and Wafaa Kaf. "Sudden Sensorineural Hearing Loss: A Hearing Emergency." Journal of Doctoral Nursing Practice 9, no. 2 (2016): 177–82. http://dx.doi.org/10.1891/2380-9418.9.2.177.

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Sudden sensorineural hearing loss (SSNHL) is a rare but emergent condition that afflicts approximately 4,000 Americans annually (Ciorba, Faita, Bianchini, Aimoni, & Scanelli, 2013; Scapa & Friedland, 2009; Stachler et al., 2012). It causes unilateral nerve loss of hearing that may not recover left untreated. Because SSNHL is uncommon, practitioners may be unaware of the urgency or the protocol for immediate testing and treatment. Aural fullness, a common presenting symptom of SSNHL, overlaps with more common outer and middle ear problems resulting in misdiagnosis and/or delayed diagnos

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Wong, Meng Yee, Wei Shuong Tang, and Zahirrudin Zakaria @ Azidin. "Unilateral sudden sensorineural hearing loss in post-COVID-19 patients: Case report." Malaysian Family Physician 17, no. 2 (2022): 112–16. http://dx.doi.org/10.51866/cr.134.

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Sudden sensorineural hearing loss (SSNHL) is an otologic emergency. Sensorineural hearing loss needs to be distinguished from conductive when patients present with sudden hearing loss at the primary care level. Prompt diagnosis of sensorineural hearing loss with pure tone audiometry and immediate treatment by an otolaryngologist can improve the hearing outcome. To date, few case reports exist about SSNHL among post-COVID-19 patients, and none were reported in Malaysia. Here, we present two cases of SSNHL in patients after COVID-19 infection. We wish to highlight the association of SSNHL follow

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Ortmann, Amanda J., and J. Gail Neely. "Sudden Sensorineural Hearing Loss and Delayed Complete Sudden Spontaneous Recovery." Journal of the American Academy of Audiology 23, no. 04 (2012): 249–55. http://dx.doi.org/10.3766/jaaa.23.4.3.

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This is a case report of a 53-yr-old female who experienced sudden sensorineural hearing loss (SSNHL) accompanied by roaring tinnitus in her right ear. The patient’s hearing partially improved in the low frequencies in response to intratympanic injections. Given that her hearing loss did not improve further, the patient was fitted with a hearing aid to mask the tinnitus and restore a sense of balance between the two ears. Approximately 9 mo postonset of the SSNHL, a complete spontaneous recovery of hearing occurred. Such a delayed and complete recovery is highly unusual.This case highlights th

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Adi Praja Semara Putra, Komang. "Addition of Hyperbaric Oxygen Therapy vs Standard Therapy in SSNHL." KESANS : International Journal of Health and Science 1, no. 4 (2022): 391–95. http://dx.doi.org/10.54543/kesans.v1i4.49.

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The background of sudden sensorineural hearing loss is that occurs suddenly, with unknown causes, and the number of cases increases with age. The modality of therapy that is often used today is empiric therapy. The purpose of this literature review is to determine the impact of adding hyperbaric oxygen therapy compared to standard therapy in cases of sudden sensorineural hearing loss. Methods The article search was carried out in various valid online data centers, namely PubMed, Science Direct, Cochrane Library, and Google Scholar. Looking for articles that discuss the addition of hyperbaric o

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Azis, Fikrilah Abdul, Afiya Shafa Kamilah, Arifiana Larasati Restyani, Athaya Miraghassani, and Henny Widyastuti. "Sudden Sensorineural Hearing Loss (SSNHL): Case Report." Medical Clinical Update 1, no. 1 (2022): 17–20. http://dx.doi.org/10.58376/mcu.v1i1.8.

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Background Sudden sensorineural hearing loss (SSNHL) commonly known as sudden deafness, is an unexplained, rapid loss of hearing either all at once or over a few days in which patients experience a sudden drop in hearing. It is commonly linked to infections, head trauma, autoimmune diseases, iatrogenic, severe infections, blood circulation problems, neurological disorders, such as multiple sclerosis, disorders of the inner ear, such as Ménière’s disease, and even metabolic disorders such as diabetes mellitus. We presented a case of sudden sensorineural hearing loss in a secondary hospita

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Kong, Tae Hoon. "Prognostic factors of sudden sensorineural hearing loss." Journal of the Korean Medical Association 66, no. 10 (2023): 573–80. http://dx.doi.org/10.5124/jkma.2023.66.10.573.

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Background: Sudden sensorineural hearing loss (SSNHL) refers to rapid and often unexplained decline in auditory acuity. Reported recovery rates for SSNHL vary across studies; however, these are usually within the range of 40% to 60%. Although numerous studies have investigated factors that affect auditory restoration, prediction of patients’ hearing recovery remains challenging.Current Concepts: Natural recovery rates for SSNHL range between 32.0% and 65.0%, and treatments commonly include systemic steroid therapy and intratympanic dexamethasone injections. Adjunctive treatments, such as antiv

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Qian, Yi, Houyong Kang, Guohua Hu, et al. "Sudden sensorineural hearing loss during pregnancy: etiology, treatment, and outcome." Journal of International Medical Research 49, no. 2 (2021): 030006052199098. http://dx.doi.org/10.1177/0300060521990983.

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Objective To analyze the etiologies, treatments, and outcomes of sensorineural hearing loss (SSNHL) during pregnancy. Study design Retrospective chart review of 25 pregnant patients treated for SSNHL between January 2012 and September 2019. Forty-nine age matched non-pregnant women with severe and profound hearing loss diagnosed with SSNHL during the same period served as controls. Data were recorded on age, symptoms, onset of hearing loss, audiometric results, treatments, and outcomes. Results The mean age was 29.6 years (range 23–38 years). Intratympanic steroids (ITS) were administered in 1

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LeGros, Tracy Leigh, and Heather Murphy-Lavoie. "Sudden Sensorineural Hearing Loss." Undersea and Hyperbaric Medicine 51, no. 4 (2024): 425–48. https://doi.org/10.22462/e15ch9.

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LeGros TL, Murphy-Lavoie H. Hyperbaric Treatment of Air or Gas Embolism: Current Recommendations. Undersea Hyperb Med. 2024 Fourth Quarter; 51(4):425-448. Sudden sensorineural hearing loss (SSNHL) presents as the abrupt onset of hearing loss. Approximately 88% of SSNHL has no identifiable etiology and is termed idiopathic sudden sensorineural hearing loss (ISSHL) [1]. Hearing specialists have investigated ISSHL since the 1970s. Over the past 30 years, more than 800 articles, or one every two weeks, have been published in the English medical literature [2]. ISSHL is the abrupt onset of hearing

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Friedland, David Richard, and Nima L. Shemirani. "Practice Guidelines for Sudden Sensorineural Hearing Loss." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P58. http://dx.doi.org/10.1016/j.otohns.2008.05.188.

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Objective To identify and compare patterns of treatment for sudden sensorineural hearing loss among otolaryngologists and primary care physicians. Methods A multiple choice and Likert scale survey was mailed to 1,306 otolaryngologists and primary care physicians throughout our state, regarding treatment and management approaches to SSNHL. Survey answers were analyzed by scope of practice and years of experience. Treatment protocols were compared among family practitioners, internists, general otolaryngologists, and otologists. Results A surprisingly large number of general practitioners treat

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Mierzwa, Kathleen, Gerlind Schneider, and Andreas Müller. "Sudden sensorineural hearing loss during oral anticoagulant therapy." Journal of Laryngology & Otology 118, no. 11 (2004): 872–76. http://dx.doi.org/10.1258/0022215042703778.

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This study investigated the role of sudden sensorineural hearing loss (SSNHL) as a symptom in oral anticoagulant therapy with vitamin K antagonists (Phenprocoumon; Marcumar®, Falithrom®). Vascular compromise of the cochlea due to thrombosis, embolus, reduced blood flow or vasospasm is one of the four possible pathways that can lead to SSNHL. Oral anticoagulant therapy should prevent thrombosis; if it does not the question arises as to whether the anticoagulation is working, or the wrong hypothesis of vascular compromise has been made. Patients with SSNHL during oral anticoagulant therapy who w

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Shapiro, MD, Scott, Brian Wiseman, BS, Brian Kellermeyer, MD, Michele Carr, MD, DMD, PhD, Stephen Wetmore MD, MBA, and Adam Cassis, MD. "Delays in care of sudden sensorineural hearing loss, an unrecognized emergency." West Virginia Medical Journal 115, no. 1 (2019): 24–29. http://dx.doi.org/10.21885/wvmj.2019.3.

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Sudden sensorineural hearing loss (SSNHL) is an acute loss of hearing due to poorly understood insults to the inner ear. SSNHL is a medical emergency warranting urgent referral to an otolaryngology specialist because hearing outcomes are improved with steroid treatment that must be administered soon after the onset of hearing loss to be effective, making early diagnosis and triage essential to salvaging hearing. This prospective study catalogued the timeline of the onset of hearing loss, diagnosis, treatment, and settings where care was administered for patients with SSNHL. We diagnosed 21 pat

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Sowula, Klaudia, Joanna Szaleniec, Kamila Stolcman, Piotr Ceranowicz, Sebastian Kocoń, and Jerzy Tomik. "Association between Sudden Sensorineural Hearing Loss and Lyme Disease." Journal of Clinical Medicine 10, no. 5 (2021): 1130. http://dx.doi.org/10.3390/jcm10051130.

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Objectives: Sudden sensorineural hearing loss (SSNHL) is defined as sensorineural hearing loss of 30 dB or more over at least three adjacent audiometric frequencies occurring within a 72-h period of time. One of the causes of SSNHL could be the progressive inflammatory state caused by an infection. The aim of this study was to assess the prevalence of SSNHL caused by various factors, most importantly those potentially related to Lyme disease. Material and Methods: The study includes a group of 86 patients between the ages of 20 and 70 who were hospitalized due to SSNHL between 2017 and 2018. A

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Tang, Jiqin. "A Preliminary Study on the Potential Mechanism of Notch Signaling Pathway in the Regulation of Sudden Sensorineural Hearing Loss." Otolaryngology Open Access Journal 7, no. 2 (2022): 1–7. http://dx.doi.org/10.23880/ooaj-16000243.

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Sudden sensorineural hearing loss (SSHNL) is a sudden onset of unexplained sensorineural hearing loss. Studies have shown that the number of patients with SSNHL is increasing year by year, and the average age is decreasing, which seriously affects the quality of life of patients. Its pathogenesis is complex and the mechanisms of hearing loss caused by various causes are quite different, but no matter what the cause is, it is ultimately related to the damage and loss of the inner ear structural hair cells (HCs) and their associated spiral ganglion cells (SGCs). Studies have shown that the Notch

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Athina Zarachi, Angelos Liontos, and Litsou Eleni. "The risk of stroke in patients with sensorineural hearing loss." International Journal of Science and Research Archive 14, no. 2 (2025): 329–32. https://doi.org/10.30574/ijsra.2025.14.2.0293.

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Purpose: to provide a comprehensive analysis of the relation between stroke and sensorineural hearing loss. Methods: An extensive review of the international bibliography has been performed on the risk of stroke in patients with sudden sensorineural hearing loss. Results: There is a growing number of reports on the risk of stroke in sudden sensorineural hearing loss. Conclusions: Clinicians should always suspect and associate the SSNHL with the risk of stroke.

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Laras, Al Ciptaning, and Ray W. Basrowi. "Association between Metabolic Syndrome Components and Sudden Sensorineural Hearing Loss." Indonesian Journal of Community and Occupational Medicine 3, no. 1 (2023): 63–72. http://dx.doi.org/10.53773/ijcom.v3i1.95.63-72.

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Introduction: Sudden sensorineural hearing loss (SSNHL) is a common form of hearing loss, and has been associated with several inflammatory diseases, which are known to cause vascular and neurological problems. Metabolic syndrome, whose main components are diabetes mellitus and dyslipidaemia, is considered a chronic inflammatory disease. Since both medical conditions share common aetiology, this literature review aims to examine the potential correlation/association between SSNHL and metabolic syndrome and the prognosis by analysing electronic databases.Methods: A literature review which syste

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Koumpa, Foteini Stefania, Cillian T. Forde, and Joseph G. Manjaly. "Sudden irreversible hearing loss post COVID-19." BMJ Case Reports 13, no. 11 (2020): e238419. http://dx.doi.org/10.1136/bcr-2020-238419.

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Sudden onset sensorineural hearing loss (SSNHL) is frequently seen by otolaryngologists. The exact pathophysiology of the disease is still unknown, with the most likely causative factor being following a viral infection. Immediate steroids are the best treatment to improve prognosis. Despite a plethora of papers in the literature describing SSNHL, there are only a few reported cases of hearing loss following COVID-19, none of which have been reported in the UK. This paper presents the first UK case of SSNHL following COVID-19. Physical examination and imaging excluded any other cause of hearin

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Um, Jae-Young, Chul-Ho Jang, Kyu-Yeob Kim, et al. "Candidate Genes of Cerebrovascular Disease and Sudden Sensorineural Hearing Loss." Clinical and Applied Thrombosis/Hemostasis 16, no. 5 (2009): 559–62. http://dx.doi.org/10.1177/1076029609348313.

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Auditory dysfunction is related to large/small vessel occlusions and hemorrhage. Sudden sensorineural hearing loss (SSNHL) frequently occurs with anterior inferior cerebellar artery occlusion proximal to the internal auditory artery. Moreover, SSNHL has various pathogenetic mechanisms, the main proposed mechanisms being vascular disease, membrane ruptures, infection, and autoimmunity. Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of cerebrovascular diseases. In the current study, the possible effects of polymorphisms in TNF-α and TNF-β genes on SSNHL are eval

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Grochowska, Barbara, Katarzyna Głuszko, Anna Koniewska, Natalia Zięba, and Maciej Misiołek. "Sudden sensorineural hearing loss during pregnancy. A case study and literature review." Polski Przegląd Otorynolaryngologiczny 13, no. 3 (2024): 42–46. http://dx.doi.org/10.5604/01.3001.0054.7074.

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<b>Introduction:</b> Sudden sensorineural hearing loss (SSNHL) is defined as the sudden onset of hearing loss of 30 dB or more, across three consecutive frequencies in a pure-tone audiogram occurring within a 72-hour period. The term “sensorineural” indicates that the cause of the hearing loss lies in disturbances within the cochlea or auditory nerve. SSNHL typically presents as unilateral, transient hearing loss that occurs upon awakening. Bilateral hearing loss occurs in less than 2% of patients. Additionally, patients may report sensations of ear fullness or blockage, tinnitus,

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Venkatraman, Anusha, Santosh Balasaheb Mane, Kamalika Purkayastha Roy, and Poonam Khairnar. "Cocktail regimen in treatment of sudden sensorineural hearing loss." IP Journal of Otorhinolaryngology and Allied Science 7, no. 1 (2024): 7–11. http://dx.doi.org/10.18231/j.ijoas.2024.003.

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This study aims to evaluate the efficacy of a cocktail regimen for the treatment of sudden sensorineural hearing loss (SSNHL). A prospective observational study. Tertiary care hospital. Thirty-five patients diagnosed with SSNHL who met the inclusion criteria. The cocktail regimen included intratympanic steroid injections, oral steroids, valacyclovir, and pentoxifylline. The primary outcome was the change in Pure Tone Audiometry (PTA) from pre-treatment to 3 months post-treatment, analyzed by Modified Siegel’s criteria. Of the 35 patients, 26 (74.2%) showed hearing improvement (including comple

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Xie, Shaobing, and Xuewen Wu. "Clinical management and progress in sudden sensorineural hearing loss during pregnancy." Journal of International Medical Research 48, no. 2 (2019): 030006051987071. http://dx.doi.org/10.1177/0300060519870718.

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Sudden sensorineural hearing loss (SSNHL) is a relatively rare, but distressing, disease in pregnant women. Little is known about the causes, clinical manifestations, treatments, and prognosis of SSNHL. Some hypotheses have been proposed to explain the pathophysiological mechanism of SSNHL, but most of them have not been identified. This article reviews the existing literature to present a summary of this clinical problem. Most patients suffer from SSNHL in the second or third trimester, and show moderate to profound hearing loss. The interval between the initial treatment and onset of hearing

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Siska Citra Amalia, Nyilo Purnami, Rosa Falerina, and Nugroho Suharsono. "Sudden sensorineural hearing loss in COVID-19 patient with hearing improvement." International Journal of Life Science Research Archive 4, no. 2 (2023): 063–67. http://dx.doi.org/10.53771/ijlsra.2023.4.2.0052.

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Introduction: Sudden Sensorineural Hearing Loss (SSNHL) is a newly revealed clinical manifestation in COVID-19 patients. This is because corona virus is thought to cause auditory neuropathy spectrum disorders, inflammation, hypoxia due to erythrocyte deoxygenation, ischemia due to vascular occlusion, and immunological reactions that induce cellular stress pathways in peripheral to central auditory organs. Case: A case of SSNHL in patient who were confirmed positive for PCR swab. A 66-year-old man with severe COVID-19, with hypertension and DM, had moderate right SNHL, left severe SNHL, when th

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M., Muniraju, Shambulinga Killera, and Safina Kauser. "A polydrug regime for treatment of sudden sensorineural hearing loss." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 12 (2020): 2275. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20205072.

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<p>Sudden sensorineural hearing loss (SSNHL) is a very frightening and incapacitating event and it impairs the patient's quality of life. Steroids are considered the first line of treatment. Intratympanic dexamethasone produces a significantly higher perilymph concentration of steroids. The aim of our study was to assess the efficacy of multi-drug regimen in the management of SSNHL, to analyse the recovery and to assess use of intratympanic steroid injections (ITSI) as a primary treatment. This is a prospective study presenting as a case series of 5 cases of SSNHL. Our treatment included

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Abouzari, Mehdi, Arash Abiri, Karen Tawk, et al. "White Matter Hyperintensity in Patients with Sudden Sensorineural Hearing Loss." Diagnostics 14, no. 11 (2024): 1109. http://dx.doi.org/10.3390/diagnostics14111109.

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Objective: To compare white matter hyperintensities (WMHs) on T2-weighted magnetic resonance imaging (MRI) of patients with sudden sensorineural hearing loss (SSNHL) and analyze subpopulations with age-matched controls. Methods: T2-weighted MRI scans of 150 patients with SSNHL were assessed for WMHs and compared with the data of 148 healthy age-matched adults. Assessments of WMHs included independent grading of deep white matter hyperintensities (DWMHs) and periventricular hyperintensities (PVHs). WMH severity was visually rated using the Fazekas and Mirsen scales by two independent observers.

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Chen, Xin, Yao-yao Fu, and Tian-yu Zhang. "Role of viral infection in sudden hearing loss." Journal of International Medical Research 47, no. 7 (2019): 2865–72. http://dx.doi.org/10.1177/0300060519847860.

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According to a recent epidemiological survey, the incidence of sudden sensorineural hearing loss (SSNHL) is increasing yearly. The cause of SSNHL is of great interest in research. To date, viral infection, vascular occlusion, abnormal cellular stress responses within the cochlea, and immune-mediated mechanisms are considered the most likely etiologies of this disease. Among these etiologies, the relationship between viral infection and sudden deafness has been unclear. In this review, we mainly discuss the viral hypothesis of SSNHL. There is little research proving or clearly indicating the pa

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Srivastava, Trisha, Shashidhar Tatavarthy, Dilpreet Bajwa, Indresh Chandra, and Altrin D. S. Benny. "Echoes of mumps: exploring sensorineural hearing loss." International Journal of Otorhinolaryngology and Head and Neck Surgery 10, no. 6 (2024): 710–14. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20243512.

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To investigate the role of intratympanic steroids and hyperbaric oxygen therapy in treating sudden sensorineural hearing loss (SSNHL) following acute viral mumps illness. Mumps is commonly associated with fever, headache, muscle aches, and parotid gland swelling but can also lead to severe complications such as SNHL, resulting from inner ear or auditory nerve damage. Eight cases of sudden-onset SSNHL of severe to profound nature presented in our OPD. Two patients were under 15 years old, and the rest were middle-aged. Treatment included oral steroids, antibiotics, and intratympanic steroids (i

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Chandrasekhar, Sujana S., Deena B. Hollingsworth, Taskin M. Monjur, and Lisa Satterfield. "Plain Language Summary: Sudden Hearing Loss." Otolaryngology–Head and Neck Surgery 161, no. 2 (2019): 211–17. http://dx.doi.org/10.1177/0194599819859884.

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This plain language summary explains sudden hearing loss (SHL) to patients and focuses on sudden sensorineural (pronounced sen-suh-ree-noo r-uh l) hearing loss (SSNHL). The summary is for adult patients aged 18 and over and is based on the 2019 “Clinical Practice Guideline: Sudden Hearing Loss (Update).” The guideline uses research to advise doctors and other health care providers on the proper testing and treatment of patients with SSNHL. The guideline includes recommendations that are explained in this summary. Recommendations may not apply to every patient but can be used to help patients a

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Chen, Jiawei, Bo Hu, Peng Qin, et al. "Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss." Neural Plasticity 2020 (September 22, 2020): 1–11. http://dx.doi.org/10.1155/2020/9460364.

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Background. Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. This study is aimed at investigating brain functional changes in SSNHL via functional magnetic resonance imaging (fMRI). Methods. Thirty-six patients with SSNHL and thirty well-matched normal hearing individuals underwent resting-state fMRI. Amplitude of low-frequency fluctuation

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Yamada, Satoshi, Junya Kita, Daichi Shinmura, et al. "Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis." Journal of Clinical Medicine 11, no. 21 (2022): 6387. http://dx.doi.org/10.3390/jcm11216387.

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Sudden sensorineural hearing loss (SSNHL) is routinely encountered and is one of the most common emergent diseases in otolaryngology clinics. However, the etiology of SSNHL remains unclear. Due to the inaccessibility of the living human inner ear for biopsy, studies investigating the etiology of SSNHL have been performed by analyzing data obtained from examinations using peripheral blood or imaging. We updated the findings obtained from serological, magnetic resonance imaging, genetic, and viral examinations to reveal the etiology of SSNHL. Regarding viral examination, we focused on sensorineu

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Putranto, Fikri Mirza, Eka Dian Safitri, and Ardys Shafira. "Round window sealing with steroid-soaked sponge in sudden sensorineural hearing loss." Oto Rhino Laryngologica Indonesiana 54, no. 1 (2024): 69–79. https://doi.org/10.32637/orli.v54i1.654.

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Background: A rescue treatment is needed in cases of Sudden Sensorineural Hearing Loss (SSNHL)which fail to obtain complete hearing restoration after conservative steroid therapy. In order to acquirebetter access of steroid to the cochlea, sealing the round window with a sponge soaked in steroid couldbe considered as an alternative delivery strategy. Purpose: To review the evidence about the impact ofround window sealing in SSNHL patients whose hearing failed to recover completely after treated withsystemic and/or intratympanic steroid. Cases: Seven patients with SSNHL, who had experienced eit

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Jang, Chul Ho, and Young Ho Kim. "Sudden hearing loss in intralabyrinthine haemorrhage in a child." Journal of Laryngology & Otology 118, no. 6 (2004): 450–52. http://dx.doi.org/10.1258/002221504323219581.

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This paper reports an unusual case in which aseptic meningitis presented with sudden sensorineural hearing loss (SSNHL) associated with intralabyrinthine haemorrhage (ILH). A seven-year-old girl presented with sudden right-sided hearing loss with dizziness. She did not have a previous history of bleeding disorders. This child was assessed using audiograms and magnetic resonance imaging (MRI). The patient's hearing loss was irreversible. Steroid therapy was not effective. SSNHL associated with ILH can be one of the negative prognostic factors in children.

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Doo, Jeon Gang, Dokyoung Kim, Yong Kim, et al. "Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss." International Journal of Molecular Sciences 21, no. 19 (2020): 7248. http://dx.doi.org/10.3390/ijms21197248.

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Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. Th

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Abe, Yasunori, Masahiro Okada, Keiko Tanaka, Kensuke Toyama, Yoshito Miyamoto, and Naohito Hato. "The Association Between Dehydration and the Prognosis of Sudden Sensorineural Hearing Loss." Otology & Neurotology Open 3, no. 4 (2023): e041. http://dx.doi.org/10.1097/ono.0000000000000041.

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Background: There is an urgent need to identify undetermined risk factors for sudden sensorineural hearing loss (SSNHL) for the development of effective treatment strategies. SSNHL is likely associated with vascular insufficiency; however, no study has evaluated the relationship between dehydration and SSNHL. Objective: This study aimed to investigate the role of dehydration in the development and prognosis of sudden sensorineural hearing loss. Study Design: Retrospective case-control study. Setting: Secondary referral hospital. Patients and Interventions: This was a comparative study that com

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Arijit, Das, Mahato Radheshyam, Prakash Sangeeth, et al. "A Study on Role of Intra Tympanic Steroids Vs oral Steroids on Sudden Sensorineural Hearing Loss in A tertiary Care Centre." International Journal of Toxicological and Pharmacological Research 14, no. 10 (2024): 98–105. https://doi.org/10.5281/zenodo.14536913.

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<strong>Background: </strong>Sudden sensory-neural hearing loss (SSNHL) is defined as loss of hearing within 3 days, more than 30 dB in consecutive 3 frequencies. It is an otological emergency for which a definitive aetiology is unknown in most of the cases and treatment remains controversial. Prompt diagnosis and management have shown to improve hearing outcomes. <strong>Methods</strong>: In our study we assigned patients to 2 groups randomly selected from patients fulfilling the criteria of SSNHL. All the patients with SSHNL between the study periods were taken in the study. After

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Cavallaro, Giada, Alessandra Pantaleo, Vito Pontillo, Francesco Barbara, Alessandra Murri, and Nicola Quaranta. "Endothelial Dysfunction and Metabolic Disorders in Patients with Sudden Sensorineural Hearing Loss." Medicina 59, no. 10 (2023): 1718. http://dx.doi.org/10.3390/medicina59101718.

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Sudden sensorineural hearing loss (SSNHL) is defined as a sensorineural hearing loss of 30 dB or greater on at least three contiguous audiometric frequencies occurring within a 72 h period. Although SSNHL is commonly encountered in clinical audiology and otolaryngology practice, its etiopathogenesis continues to be poorly understood. Scientific investigations have highlighted the vulnerability of cochlear microcirculation to blood flow alterations. Even mild hypoperfusion can lead to immediate dysfunction in the organ of Corti, given the heightened susceptibility of cochlear hair cells to hypo

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Aldè, Mirko, Umberto Ambrosetti, Gioia Piatti, et al. "Sudden Sensorineural Hearing Loss in Patients Aged from 15 to 40 Years." Journal of Clinical Medicine 13, no. 11 (2024): 3303. http://dx.doi.org/10.3390/jcm13113303.

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Objectives: The purpose of this study was to investigate the hearing characteristics and causes of sudden sensorineural hearing loss (SSNHL) in patients aged from 15 to 40 years, focusing on audiological outcomes one year after the diagnosis. Methods: The medical records of individuals with SSNHL who were referred to our tertiary-level audiologic center were reviewed. All patients had undergone comprehensive diagnostic evaluations, including high-resolution 3D-FLAIR delayed magnetic resonance imaging (MRI), cone beam computed tomography (CBCT), and screening for coagulation, infectious, and au

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Delphi, Maryam, and Maryam Kardouni. "Sudden Sensorineural Hearing Loss in a Patient with COVID-19: A Case Report." Journal of Kerman University of Medical Sciences 30, no. 2 (2023): 123–25. http://dx.doi.org/10.34172/jkmu.2023.20.

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Background: Several viral infections may lead to hearing loss. It›s still unknown whether COVID-19 has effects on the auditory system or not. In this regard, to evaluate the possibility of sudden sensorineural hearing loss due to COVID-19, this study aimed to report sudden sensorineural hearing loss (SSNHL) in patients with COVID-19 in Iran. Case Report: The patient was a 7-year-old girl diagnosed with COVID-19 and sensorineural hearing loss. An audiogram revealed normal hearing in the right ear and severe sensorineural hearing loss in the left ear. The tympanometry test result was bilateral t

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Lee, Hyeon A., and Jae Ho Chung. "Contemporary Review of Idiopathic Sudden Sensorineural Hearing Loss: Management and Prognosis." Journal of Audiology and Otology 28, no. 1 (2024): 10–17. http://dx.doi.org/10.7874/jao.2024.00024.

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Sudden sensorineural hearing loss (SSNHL) is a rapid decline in auditory function that needs urgent medical management. Although etiologic factors, including viral infections, autoimmune diseases, and vascular issues, contribute to the understanding of SSNHL, the condition remains unclear in most cases. Systemic steroids are often used as the first-line treatment because they reduce inner ear inflammation; however, there remains numerous discussions about the effectiveness of alternative treatments. To predict hearing recovery is crucial in patients’ counseling with factors, including delayed

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Cao, Zaizai, Jinjian Gao, Saiyu Huang, et al. "Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review." Audiology and Neurotology 24, no. 1 (2019): 8–19. http://dx.doi.org/10.1159/000497032.

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Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summar

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Swain, Santosh Kumar. "COVID-19 patients and sudden sensorineural hearing loss: a review." International Journal of Otorhinolaryngology and Head and Neck Surgery 8, no. 4 (2022): 437. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20220820.

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<p>Coronavirus disease-19 (COVID-19) is a new pandemic caused by SARS-CoV-2 virus. COVID-19 patients often present with respiratory symptoms and death is the possible outcome. The potentiality for neuro-invasion by the SARS-CoV-2 is currently a subject of great debate. However, there is a paucity of information regarding the impact of the SARS-CoV-2 on the nervous system at the present moment. The impact of the coronavirus on the auditory system is little mentioned in the literature. Sudden sensorineural hearing loss (SSNHL) is a rare symptom associated with COVID-19 infection. This hear

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Riera, Julia L., María del R. Maliandi, Jorge L. Musuruana, and Javier A. Cavallasca. "Sudden Sensorineural Hearing Loss in Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Clinical Review." Current Rheumatology Reviews 16, no. 2 (2020): 84–91. http://dx.doi.org/10.2174/1573397115666191016101741.

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Background: Sudden sensorineural hearing loss (SSNHL) is defined as a sudden loss of hearing, usually unilateral, of more than 30 dB in 3 contiguous frequencies of the tonal audiometry. SSNHL estimates an incidence ranging from 5 to 20 per 100.000 people per year. In approximately 75% of cases, a cause cannot be identified. However, it could be a clinical manifestation of Systemic lupus erythematosus (SLE) and Antiphospholipid Syndrome (APS). Objective: This review will focus on the clinical presentation, diagnosis, and management of the SLE and APS associated SSNHL. Methods: We searched in Pu

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Nishimura, Tadashi, Tadao Okayasu, Chihiro Morimoto, Sakie Akasaka, Tadashi Kitahara, and Hiroshi Hosoi. "Evaluation of the Recovery of Idiopathic Sudden Sensorineural Hearing Loss Based on Estimated Hearing Disorders." Audiology Research 12, no. 5 (2022): 476–84. http://dx.doi.org/10.3390/audiolres12050048.

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Various prognostic factors for idiopathic sudden sensorineural hearing loss (SSNHL) have been reported. Hearing loss directly derived from idiopathic SSNHL is important for understanding underlying pathogenesis and outcomes. We assessed the usefulness of evaluating hearing loss and recovery of idiopathic SSNHL on the basis of estimated hearing loss. The study included 115 patients whose characteristics and outcomes of hearing loss were investigated. The effects of vertigo/dizziness and age on hearing thresholds before/after treatment, nonaffected ear threshold, estimated hearing loss, improvem

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Sweta, Sinha, Nand Pal Viddya, Rakhiyae Navneet, and Sharma Satyendra. "Sudden Sensorineural Hearing Loss: A Research of Diagnosis, Treatment, and Prognosis." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1568–73. https://doi.org/10.5281/zenodo.12760274.

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<strong>Background:</strong> Sudden Sensorineural Hearing Loss (SSNHL) is a severe clinical challenge that frequently lacks an etiology. After multiple intratympanic injections and corticosteroids, results are still uncertain, so we need to determine what predicts a good prognosis and how to manage it. <strong>Methods:</strong> From April 2023 to March 2024, 80 patients from Nalanda Medical College and Hospital SSNHL were included in this retrospective cohort research. Demographic factors included age, gender, and comorbidities. Imaging and audiometric results were analyzed for

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Kang, Ji-Yeon, Se-Hyeong Kim, and Seung-Hyo Choi. "Treatment of 3 patients with sudden sensorineural Hearing loss for more Than 1 year." Journal of Medicine and Life Science 9, no. 2 (2012): 106–9. http://dx.doi.org/10.22730/jmls.2012.9.2.106.

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Generally sensorineural hearing loss (SNHL) is progressive and intractable. However, sudden SNHL (SSNHL) is curable and has various prognosis. The prognosis of SSNHL depends on a variety of risk factors including demographics, duration of hearing loss, associated symptoms, and audiogram characteristics. Presentation to a physician less than a week after onset of SSNHL also correlates with improved oddsof hearing recovery, with chances of complete hearing recovery decreasing after that time. Nevertheless we treated 3 patients with SSNHL more than 1 year passed after onset of disease. We did int

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Hughes, Charlotte K., Jakob Fischer, Carlos R. Esquivel, and Adrienne M. Laury. "Sudden Sensorineural Hearing Loss in the Department of Defense." Otolaryngology–Head and Neck Surgery 159, no. 2 (2018): 354–58. http://dx.doi.org/10.1177/0194599818768511.

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Objective The American Academy of Otolaryngology—Head and Neck Surgery Foundation clinical practice guideline (CPG) proposes recommendations regarding sudden sensorineural hearing loss (SSNHL). SSNHL is managed by primary care, emergency medicine, and otolaryngology providers in the Department of Defense (DoD). However, their adherence to this CPG is unknown. We sought to determine provider compliance and identify areas for improvement. Study Design Case series with chart review. Setting DoD’s electronic medical record. Subjects and Methods Patients with SSNHL (N = 204) were treated between Ma

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Shrestha, Palpasa, Bibek Shrestha, and Jun Chen. "Effect of Stress in Unilateral Sudden Sensorineural Hearing Loss Patients." International Journal of Medical Imaging 13, no. 1 (2025): 1–6. https://doi.org/10.11648/j.ijmi.20251301.11.

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The aim of this study is to investigated the relationship between stress markers and Sudden Sensorineural Hearing Loss patients. This retrospective study was approved by the Renmin Hospital of Wuhan University. We collected Magnetic resonance imaging (MRI) images and data of 41 patients in our hospital. All patients underwent conventional MRI. An independent sample t-test was utilized for continuous data, and a chi-square test was employed for categorical data. We utilized logistic and linear regression analyses to evaluate the relationship between Sudden Sensorineural Hearing Loss (SSNHL) and

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Ju, Yeo Rim, Hyoung-sik Park, Min Young Lee, Jae Yun Jung, and Ji Eun Choi. "Clinical Features and Hearing Outcomes of Sudden Sensorineural Hearing Loss in Diabetic Patients." Journal of Audiology and Otology 25, no. 1 (2021): 27–35. http://dx.doi.org/10.7874/jao.2020.00262.

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Background and Objectives: This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients.Subjects and Methods: Forty-nine diabetic with unilateral SSNHL were retrospectively included. All patients received systemic high dose steroid therapy within one month after onset and had more than one month of follow-up audiogram. The basic characteristics of the patients, initial and follow-up audiograms, laboratory data, and methods of steroid treatment were collected.Results: Compared to reference

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Ungar, Omer J., Oren Cavel, Yahav Oron, Anat Wengier, Oshri Wasserzug, and Ophir Handzel. "A Subjective Rating Scale for Initial Assessment of Sudden Unilateral Sensorineural Hearing Loss." Audiology and Neurotology 22, no. 3 (2017): 154–59. http://dx.doi.org/10.1159/000479723.

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Objective: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available. Study Design: Prospective noncontrolled clinical study. Methods: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled. Patients were asked to characterize the severity of their hearing loss using an NRS of 1 (normal hearing) to 6 (c

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Nunez, Desmond A., Reyhaneh Abgoon, Printha Wijesinghe, and Cathie Garnis. "Serum and Plasma miRNA Expression Levels in Sudden Sensorineural Hearing Loss." International Journal of Molecular Sciences 26, no. 3 (2025): 1245. https://doi.org/10.3390/ijms26031245.

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Sudden sensorineural hearing loss (SSNHL) is a rapidly developing acquired idiopathic disorder. Differential expressions of microRNAs (miRNAs) have been identified in the acute serum of SSNHL patients. miRNAs are transmitted in both serum and plasma, but it is unknown which better reflects changes associated with inner ear disease. Therefore, we sought to compare the serum and plasma miRNA expression levels in adult SSNHL patients. We extracted and reverse transcribed total RNA from serum and plasma, and analyzed the product with quantitative real-time PCR. hsa-miR-191-5p was used for normaliz

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Mezri, Sameh, Mariem Selmi, and Selma Bessioud. "Case Report: - Sudden sensorineural hearing loss and vertigo due to inner ear hemorrhage." F1000Research 13 (September 2, 2024): 668. http://dx.doi.org/10.12688/f1000research.151547.2.

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Sudden deafness is a common cause of emergency consultation in otology. Usually, despite investigations, no etiology is known. Intracochlear hemorrhage is a rare cause of sudden sensorineural hearing loss (SSNHL) and may be associated with various labyrinthine disorders. In such cases, magnetic resonance imaging (MRI) is the clef of the diagnosis. We report the case of a 70-year-old patient who was referred to our department for sudden hearing loss, tinnitus, and vertigo. Otoscopic and neurological examinations were normal, and pure-tone audiometry revealed left profound sensorineural hearing

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Mezri, Sameh, Mariem Selmi, and Selma Bessioud. "Case Report - Sudden sensorineural hearing loss and vertigo due to inner ear hemorrhage." F1000Research 13 (June 21, 2024): 668. http://dx.doi.org/10.12688/f1000research.151547.1.

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Sudden deafness is a common cause of emergency consultation in otology. Usually, despite investigations, no etiology is known. Intracochlear hemorrhage is a rare cause of sudden sensorineural hearing loss (SSNHL) and may be associated with various labyrinthine disorders. In such cases, magnetic resonance imaging (MRI) is the clef of the diagnosis. We report the case of a 70-year-old patient who was referred to our department for sudden hearing loss, tinnitus, and vertigo. Otoscopic and neurological examinations were normal, and pure-tone audiometry revealed left profound sensorineural hearing

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