Academic literature on the topic 'Sulphonamide drugs'

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Journal articles on the topic "Sulphonamide drugs"

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Alfredsson, Gunnel, and Anita Ohlsson. "Stability of sulphonamide drugs in meat during storage." Food Additives and Contaminants 15, no. 3 (April 1998): 302–6. http://dx.doi.org/10.1080/02652039809374645.

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Mohammed, Aliaa A. Razzak, Ahmed J. Muklive Al-Ogaidi, and Abeer Abdul Razak Mohammed. "Micro Evaluation of Sulphonamide in Biological Samples by Coupling Reaction." International Journal of Drug Delivery Technology 10, no. 03 (September 25, 2020): 509–12. http://dx.doi.org/10.25258/ijddt.10.3.35.

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Sulphonamide is considered a turning point for therapeutic science. Structural changes in sulphonamide can lead to the formation of various drugs used for combating different diseases. Sulphonamide can be used in different applications, such as, antitumor agents, carbonic anhydrase inhibitors, anti-bacterials, hypoglycaemic agents, protease inhibitors, and diuretics. The most important thing for this assay is to find a modified approach to assess sulphonamide by utilizing an organic reaction that depends on a process of coupling between our target material (sulphonamide) with 4-amino antipyrine in basic media of phosphate buffer (pH = 11.3), forming a colored complex containing a higher molar absorptivity (wavelength = 457 nanometers). A preliminary investigation test was done to determine the typical condition for this reaction to determine the concentration curve for the interval 8.25 × 10-9 to 1.15 × 10-2 ppm, and the absorptivity molar was 2.1 × 104 L.mol-1.cm-1, RSD value greater than 1.12%, with a percentage of recovery of approximately 99.88%. We obtained the result and got the approved mole ratio for this reaction about 1:1 (sulphonamide:diazotized amino compound); the value of the stability factor reached 2.8 × 106 L.mol-1. This proposal could be used for a fair assessment for sulphonamide determination, which has different advantages, such as, low-cost economy, no need for an expert, simplicity, no need for more time, and high-quality results in the requirement of rapid and excellent determination. This approach can be utilized for validation of sulphonamide in different active biological samples with higher efficiency.
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Kiss, László, Hiba Mohamed Ameen, Beáta Lemli, and Sándor Kunsági-Máté. "Determination of Solubility of 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic Acid and its Sodium Salt in Acetonitrile and Voltammetric Investigation of Sulphonamide Drugs in Different Solvents in Their Absence and Presence." Journal of Solution Chemistry 50, no. 1 (January 2021): 147–59. http://dx.doi.org/10.1007/s10953-020-01047-2.

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AbstractSulphonamide drugs (sulphamethazine, sulphamerazine, sulphadiazine, sulphathiazole) were studied in a wide potential window (between 2 and − 2 V) in acetonitrile, dimethyl sulphoxide and in 50–50 v/v% binary mixtures of acetonitrile and water. The voltammograms of the outlined compounds were very similar both in the anodic and cathodic part in each non-aqueous solvents except for sulphathiazole. These sulphonamide drugs were also investigated in presence of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and its sodium salt and the voltammograms changed due to an acid–base reaction. HEPES and its sodium salt could be investigated in acetonitrile only in their saturation concentration as they were slightly soluble in this solvent. In a separate experiment their solubilities were determined at 298 K in acetonitrile with the co-solvent calibration method using water as co-solvent. Complementary fluorescence studies in dimethyl sulphoxide did not show the presence of any interaction between sulphonamide drugs and HEPES as well as its sodium salt.
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Paulson, G. D., V. J. Feil, J. M. Giddings, and C. H. Lamoureux. "Lactose conjugation of sulphonamide drugs in the lactating dairy cow." Xenobiotica 22, no. 8 (January 1992): 925–39. http://dx.doi.org/10.3109/00498259209049899.

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Garg, Archana, and J. P. Tandon. "Coordination Complexes of Fe(III) with Schiff bases derived from sulphonamide drugs." Journal f�r Praktische Chemie 331, no. 1 (1989): 157–61. http://dx.doi.org/10.1002/prac.19893310126.

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Agarwal, Suraj P. "Visualization of sulphonamide drugs on thin-layer plates usingπ-acceptors as spray reagents." Journal of Chromatography A 362 (January 1986): 303–7. http://dx.doi.org/10.1016/s0021-9673(01)86982-x.

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Ali, Azza M. M. "Electroanalytical Studies of Azo Sulpha Drugs, Application to Novel Heterocyclo-Sulphonamide Azo Dye." Analytical Letters 26, no. 8 (August 1993): 1635–47. http://dx.doi.org/10.1080/00032719308021485.

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Bahadur, Indra, Sinethemba P. Manquthu, Lukman O. Olasunkanmi, and Eno E. Ebenso. "Intermolecular interactions between methanol and some sulphonamide drugs in aqueous medium using thermodynamics approach." Journal of Molecular Liquids 283 (June 2019): 451–61. http://dx.doi.org/10.1016/j.molliq.2019.03.065.

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Naikwadi, Shagupta A., and Rupali B. Jadhav. "Nimesulide induced Stevens Johnson Syndrome: a case report." International Journal of Basic & Clinical Pharmacology 6, no. 8 (July 22, 2017): 2094. http://dx.doi.org/10.18203/2319-2003.ijbcp20173303.

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Adverse drug reactions to the prescribed medicines are the major obstacles in continuation of drug treatment. Stevens- Johnson Syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction which is most commonly elicited by drugs and occasionally by infections. Common drugs associated with SJS are sulphonamide antibiotics, anticonvulsants, non- steroidal anti-inflammatory drugs (NSAIDS) and allopurinol. Nimesulide is an NSAID with analgesic and antipyretic properties. Here, we report a case of 21 years old male patient who developed Stevens Johnson Syndrome following ingestion of tablet Nimesulide. The patient was managed with parenteral corticosteroids, antibiotics, emollients, and supportive care. This case highlights the importance of Nimesulide and other NSAIDs as possible cause of SJS. Nimesulide has never been approved in countries like USA, Canada, Australia. But in India it is available as over the counter drug and is used for various indications like fever, myalgia, arthralgia. Therefore, the drugs which are banned outside India should be used with caution and practitioners should report all the adverse drug reactions to such drugs.
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Davenport, Diana. "The war against bacteria: how were sulphonamide drugs used by Britain during World War II?" Medical Humanities 38, no. 1 (October 3, 2011): 55–58. http://dx.doi.org/10.1136/medhum-2011-010024.

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Dissertations / Theses on the topic "Sulphonamide drugs"

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Justham, David. "A study of nursing practices used in the management of infection in hospitals, 1929-1948." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-nursing-practices-used-in-the-management-of-infection-in-hospitals-19291948(44276592-51ff-4bdd-9fcf-2e17d9a1d2ab).html.

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Before the availability of antibiotics minor infections could become life threatening. Nurses working in voluntary and public hospitals in Britain were exposed to such risks. This thesis uses both oral testimonies and published sources in order to examine their practices concerning the management of infection risks. The detail of nursing work in this period has been generally hidden in nursing histories of the 1930s and 1940s which have addressed mainly political, recruitment, educational, registration and status issues. Whilst these histories may comment about menial duties, and the culture and discipline in clinical areas, they lack detailed exploration of the day-to-day work of the nurse. This novel study contributes to redressing the balance by examining nursing practice between the discovery of penicillin in 1929 and its widespread availability in Britain in 1948. Data analysis, including the oral testimonies of nineteen former nurses who worked between 1929 and 1948, suggests that nursing practice during this period placed enormous emphasis on cleanliness and hygiene. It is argued that this was linked to sanitarianism which influenced nursing practice before its replacement by germ theory. Probationer nurses learnt their skills in managing infection risks to themselves and their patients in a disciplined and safe way. This was achieved through the exercise of strict routines and a hierarchy of tasks that provided a graduated exposure to the patient and infection risks. This thesis draws on debates in the literature about purity, vocation and status to explore, and add weight to this argument. The analysis also identifies that the introduction of sulphonamide drugs and antibiotics altered nursing practices in the management of both infection risks and patients with infection. Whilst the full effects of these changes are not examined in this thesis, it is argued that the significant impact of these drugs was such that the emphasis on cleaning and hygiene became diminished in importance and nursing had to redefine its role. It suggests that more prominence needs to be given to changes in clinical practice in the history of nursing. This study breaks new ground by suggesting the rigorous training of nurses in cleaning and hygiene tasks was needed in order to manage the infection risks faced by nurses before the availability of antibiotics.
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Gill, Helen J. "Relationship between the metabolism and toxicity of sulphones and sulphonamides." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366003.

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Grape, Malin. "Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-870-3/.

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Hamnca, Siyabulela. "Nanostructured polyamic acid electrocatalysts for reliable analytical reporting of sulphonamides as contaminants of emerging concern." University of the Western Cape, 2019. http://hdl.handle.net/11394/7014.

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Philosophiae Doctor - PhD
Polyamic acid (PAA) nanostructured materials were successfully produced by electrochemical deposition and electrospinning using polyvinlypyrrolidone (PVP) as supporting polymer. Polyamic acid thin film and nanofibers were deposited directly at the surface of a screen-printed carbon electrode (SPCE) as electro-catalysts for reliable analytical reporting of sulphonamide as contaminants of emerging concern by electrochemical techniques. Fourier transform infrared (FTIR) spectroscopy was used to confirm the structural integrity of the PAA electrospun nanofibers compared to the chemical synthesized PAA. Brunauer-Emmett-Teller (BET) was used to determine the surface area of the nanofibers. The surface morphology and surface thickness of the polyamic acid (PAA) nanofibers on the screen-printed electrodes was studied using scanning electron microscopy (SEM) and atomic force microscopy (AFM). Cyclic voltammetry (CV) was used to study redox behavior of the nanostructured PAA modified screen-printed carbon electrodes. Electrochemical parameters surface concentration, diffusion coefficient, formal potential and peak separation were determined. Three sulphonamides were selected based on the United States of protection agency (US EPA) and World Health Organization (WHO) list of emerging contaminants and detected sulphonamides in environmental waters in South Africa and other African regions. The selected sulfonamides were evaluated at the unmodified and modified screen-printed carbon electrodes. The sulphonamides were evaluated in three different supporting electrolytes at pH < 7 and >7 to enhance electrochemical signal reporting. Sulfadiazine (SDZ), sulfamethoxazole (SMX) and sulfamethazine (SMZ) displayed peaks at 0.80 V vs Ag/AgCl in 0.1 M tris-HCl using square wave voltammetry at the unmodified transducer. At the PAA thin film transducer, SDZ, SMX and SMZ displayed well-defined analytical oxidative peaks at 0.77 V 0.82 V and 0.83 V vs Ag/AgCl respectively. The LOD (n=3) for SDZ was found to be 12.14 ųM with a correlation coefficient of 0.9950. The LOD (n=3) for SMX and SMZ was found to 14.59 ųM (R2 =0.9928) and 10.41 ųM (R2 =0.9963). These sulphonamides were also electro-analytical evaluated at the screen-printed carbon PAA nanofiber modified transducer. SDZ, SMX and SMZ produced well-defined analytical signals at 0.79 V, 0.81 V and 0.78 V vs Ag/AgCl respectively. The determined LOD (n=3) for the individual sulphonamides was 8.26 ųM, 16.59 ųM and 8.81 ųM SDZ, SMX and SMZ respectively. The linearity correlation coefficient (R2) was determined to be 0.9977, 0.9956 and 0.9974 respectively. The efficacy of the proposed nanostructured PAA thin film modified screen-printed carbon sensor was evaluated by performing recovery studies for the selected sulphonamides using square wave voltammetry. Tap water was used to simulate environmental matrix. The recoveries of SDZ with respect to each concentration were 98.84% (RSD 4.98%) to 40.58% (RSD 6.74%). For SMX the recoveries were 154.17% (RSD 11.00%) to 111.03% (RSD 16.80%). The recoveries for SMZ with respect to each concentration were 184% (RSD 8.19%) to 90.26 (RSD 18.26%) indicating the reliability of the analytical results.
2021-09-01
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Books on the topic "Sulphonamide drugs"

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Lesch, John E. The first miracle drugs: How the sulfa drugs transformed medicine. New York, NY: Oxford University Press, 2005.

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The first miracle drugs: How the sulfa drugs transformed medicine. New York: Oxford University Press, 2006.

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Powell, Stephen E. Abstracts on sulfa drugs pertinent to livestock and poultry. Edited by Holstein-Delgass Elizabeth, Purdue University. Cooperative Extension Service., and Purdue University. Dept. of Animal Sciences. West Lafayette, Ind: Purdue University, Cooperative Extension Service [and] Animal Sciences Dept., 1985.

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Reider, Michael John. Clinical characteristics and biochemical determinants of sulphonamide hypersensitivity adverse drug reactions. 1992.

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Book chapters on the topic "Sulphonamide drugs"

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Hay, Roderick J. "Nocardiosis." In Oxford Textbook of Medicine, edited by Christopher P. Conlon, 1176–79. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0135.

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Nocardia species—Nocardia asteroides, N. brasiliensis, and N. otidiscaviarum—are Gram-positive, filamentous, partially acid-fast bacteria. They are occasionally detectable in environmental sources such as soil, but they rarely cause infections in humans, although they can give rise to a variety of different diseases. In healthy individuals, most commonly in the tropics, they can present with cutaneous abscesses or subcutaneous infections (actinomycetoma) in which the organisms are present as clusters of filaments or grains. In immunocompromised patients they cause a disseminated or localized deep infection, with particular sites affected being the lungs or brain. Diagnosis of Nocardia infection depends on culture, although histopathology is very useful in Nocardia actinomycetomasiii. Antibiotic treatment is typically with a sulphonamide (often as co-trimoxazole for lung infections), but combinations of drugs are usually given because the responsiveness of Nocardia species is very variable.
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"Antibiotics – sulphonamides." In Adverse Drug Interactions: A Handbook for Prescribers, 617–21. CRC Press, 2010. http://dx.doi.org/10.1201/b13416-76.

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Sefton, Armine. "Use of Antimicrobials and Toxicity." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0054.

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Broad-spectrum antibacterial agents kill most bacteria including gram-positive rods and cocci, gram-negative rods and cocci, and often anaerobes too. Narrow-spectrum agents kill a narrow range of microbes, e.g. benzylpenicillin is mainly active against gram-positive cocci. By and large a narrow-spectrum antimicrobial is less likely to disrupt a patient’s normal flora than a broad-spectrum agent. Hence, if the likely organism is causing an infection it is best to give a narrow-spectrum antimicrobial to treat that specific organism. If a patient presents ‘septic’ and the source of infection is unknown, relevant cultures should be taken followed by broad-spectrum antimicrobial cover. This can later be modified either when the source of infection is found or as a result of microbiology culture results. ● Agents mostly active against gram-positive bacteria include: ■ Penicillin (Also active against Neisseria spp.). ■ Fusidic acid. ■ Macrolides (Also active against Legionella, Campylobacter, Bordetella spp.). ■ Clindamycin. ■ Glycopeptides. ■ Oxazolidinones. ■ Streptogramins. ● Agents mainly active against gram-negative bacteria include: ■ Polymyxin. ■ Trimethoprim. ■ Aminoglycosides (also active against staphylococci and show synergy when combined with beta-lactams against/glycopeptides against streptococci). ■ Monobactams. ■ Temocillin. ● Broad-spectrum antimicrobials include: ■ Beta-lactam plus beta-lactamase inhibitor combinations. ■ Cephalosporins. ■ Carbapenems. ■ Chloramphenicol, Tetracyclines/Glycyclines. A bactericidal agent is a compound that actively kills multiplying bacteria. A bacteriostatic compound inhibits the growth of bacteria. Whether or not an antimicrobial is bactericidal or bacteriostatic depends on a variety of things, including the type of agent, its concentration, and the organism it is being used to treat. It is especially important to try and use a bactericidal agent if the patient’s immune system is impaired or the infection is at a site where it is difficult for the immune system to access, e.g. the heart valves in bacterial endocarditis, the meninges in meningitis. Examples of each are given here: ● Bactericidal agents include beta-lactams, glycopeptides, fluoroquinolones, and aminoglycosides. ● Bacteriostatic agents include macrolides, clindamycin, tetracyclines, trimethoprim, and sulphonamides. The therapeutic index of a drug is the ration of the concentration of drug likely to be toxic to the patient divided by the concentration of drug likely to be clinically effective.
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Conference papers on the topic "Sulphonamide drugs"

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Jordan, Allan, Ben Acton, Nicola Hamilton, James Hitchin, Colin Hutton, Dominic James, Cliff Jones, et al. "Abstract 3715: Benzimidazolone sulphonamides - potent, selective and drug-like inhibitors of poly(ADP Ribose) Glycohydrolase (PARG)." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3715.

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