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Journal articles on the topic 'Sun Exposure and Sucker Numbers'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Taye, Buke Ashango. "EFFECT OF CORM AND CORM PIECES ON REGENERATION AND MULTIPLICATION OF ENSET (ENSETE VENTRICOSUM (WELW.) CHEESMAN)." INTERNATIONAL JOURNAL OF RESEARCH- GRANTHAALAYAH 5, no. 5 (2017): 281–99. https://doi.org/10.5281/zenodo.583926.

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A field study was conducted on ‘enset’ propagation at Humbo, Wolayta. The experiments of this study were executed with the objectives of determining size of whole corms and corm pieces for better sucker production. Five whole corm sizes (0.75, 3, 7, 11and15 kg), five bigger (0.8, 1.75, 2.3, 3.5 and 4.6) and three smaller (0.2, 0.3 and 0.4 kg) corm pieces, three corm piece positions (lower, middle and top) of horizontal cut. There were significant (p<0.01) differences among corms and corm pieces in the number of suckers. Whole corms with 7 kg gave the highest number of suckers; similarly, co

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Belk, Mark C., Lisa J. Benson, Josh Rasmussen, and Steven L. Peck. "Hatchery-induced morphological variation in an endangered fish: a challenge for hatchery-based recovery efforts." Canadian Journal of Fisheries and Aquatic Sciences 65, no. 3 (2008): 401–8. http://dx.doi.org/10.1139/f07-176.

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Recovery plans for many endangered fishes include production of large numbers of individuals in hatcheries to augment wild populations. However, effects of hatchery culture on phenotypic development are poorly documented for most species. June sucker (Chasmistes liorus) is an endangered lake sucker endemic to Utah Lake (Utah, USA), and recovery plans include raising thousands of juveniles to stock in the lake. To determine effects of hatchery culture on morphology of young June sucker, we raised individuals from four different families in both lake and hatchery environments and compared shape

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Filon, Francesca Larese, Marcella Mauro, Iris Zalaudek, and Francesca Rui. "O-128 OCCUPATIONAL AND BEHAVIORAL FACTORS IN NON-MELANOMA SKIN CANCER IN NORTH EAST OF ITALY." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0763.

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Abstract Introduction Exposure to sunlight, to artificial UV-radiation and as arsenic or polycyclic aromatic hydrocarbons can cause non-melanoma skin cancer (NMSK). The majority of NMSK could be preventable by avoiding at-risk exposure. Objectives To analyze occupation, risk perception, UV exposure, preventive habits in 248 subjects affected by NMSC and 248 controls living in Trieste, North East of Italy. Methods Consecutive cases with incident NMSC and controls without skin cancers were recruited at University of Trieste. All had a medical examination and filled a standardized questionnaire o

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CHANDRA, MUDIT, SUNITA THAKUR, DEEPTI NARANG, and H. M. SAXENA. "Physical characterization of bacteriophages isolated against Salmonella Dublin." Indian Journal of Animal Sciences 82, no. 10 (2012): 1186–89. http://dx.doi.org/10.56093/ijans.v82i10.24296.

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In the present study a total of 5 phages were isolated against Salmonella Dublin using agar overlay technique from 25 samples of dairy effluent. These phages were purified, enriched and subjected to various physical (pH, temperature and sun light exposure) to evaluate their survival ability. On physical characterization of the phages it was found that the phages could survive varied pH conditions with reduction in its numbers from the initial concentration. Upon exposure to various temperature conditions it was observed that the phages can withstand a maximum 50°C and above this temperature it

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Kwan, Tammi Y., Terry W. Belke, and Tom Enta. "Sex Differences in the Anatomical Distribution of Melanocytic Nevi in Canadian Hutterite Children." Journal of Cutaneous Medicine and Surgery 4, no. 2 (2000): 58–62. http://dx.doi.org/10.1177/120347540000400202.

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Background: Studies of the distribution of melanocytic nevi (MN) and/or cutaneous malignant melanoma (CMM) in white populations have commonly observed greater numbers of MN and CMM on the torsos of males and on the limbs of females. The most commonly cited explanation for this sex difference is differential sunlight exposure of body subsites due to gender differences in clothing styles and recreational activities. Less common, but more speculative, explanations suggest hormonal differences or regional differences in melanocytes across body subsites. Objective: The purpose of the present study

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Hesterberg, Rebecca, Afua Adutwumwa Akuffo, Shalaka S. Hampras, et al. "Skin homing and highly suppressive (CD45RA−CD27−) Tregs associated with ultraviolet radiation exposure." Journal of Immunology 198, no. 1_Supplement (2017): 204.18. http://dx.doi.org/10.4049/jimmunol.198.supp.204.18.

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Abstract Immune suppression is a critical risk factor for the development of cancer. Understanding how carcinogens impact the immune system in immunocompetent individuals may give rise to relevant information about the biological processes that occur in precancerous lesions and how these contribute to cancer progression. UV radiation (UVR) is a known risk factor for keratinocyte cancer, but its association with immunosupperssive CD4+FoxP3+ regulatory T (Treg) cells is not established. To evaluate the association between UVR and Tregs, an epidemiological study (n=350) was conducted among a coho

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Augustsson, A., U. Stierner, I. Rosdahl, and M. Suurküla. "Regional distribution of melanocytic naevi in relation to sun exposure, and site-specific counts predicting total number of naevi." Acta Dermato-Venereologica 72, no. 2 (1992): 123–27. http://dx.doi.org/10.2340/0001555572123127.

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The role of exposure to ultraviolet light in the formation of melanocytic naevi was analysed by investigating the regional naevus distribution in 310 subjects (30-50 years) from a Swedish census file. The lateral aspect of the arms and the back had the largest concentration of naevi. The mean naevus count per unit surface area was higher in intermittently exposed than in rarely exposed skin (p less than 0.001), while the lowest mean count was found in chronically exposed skin. These results support the idea that intermittent exposure to ultraviolet light has a "naevogenic" effect while chronic

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Frost, Peter. "An Accelerant of Social Change? The Spanish Flu of 1918-19." International Political Anthropology 13, no. 2 (2020): 123–33. https://doi.org/10.5281/zenodo.4295574.

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Social change can be accelerated by events that eliminate or incapacitate large numbers of people who are in the prime of their lives and who, therefore, can best enforce social norms. One such event was the double shock of the Spanish flu and the First World War. By disrupting established ways and by increasing openness to new ways, it accelerated changes that were already in progress but still running into resistance or inertia. This paper will focus on two of those changes: modern evangelism, which altered the church’s role in the community, and the sunshine movement, which had impact

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Carli, Biggeri, Nardini, DE Giorgi, and Giannotti. "Sun exposure and large numbers of common and atypical melanocytic naevi: an analytical study in a southern European population." British Journal of Dermatology 138, no. 3 (1998): 422–25. http://dx.doi.org/10.1046/j.1365-2133.1998.02118.x.

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Vogelweid, C. M., R. B. Miller, J. N. Berg, and D. A. Kinden. "Scanning electron microscopy of bovine corneas irradiated with sun lamps and challenge exposed with Moraxella bovis." American Journal of Veterinary Research 47, no. 2 (1986): 378–84. https://doi.org/10.2460/ajvr.1986.47.02.378.

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SUMMARY Effects of uv radiation and irradiation followed by challenge exposure with Moraxella bovis on the corneal epithelium were studied in 6 calves by scanning electron microscopy. After UV irradiation, the number of dark cells comprising the surface epithelium increased. Many epithelial cells were in various states of degeneration and were characterized initially by large round nuclei, whereas sloughing and peeling were characteristic of the last degenerative stage. All M bovis-infected irradiated eyes had large numbers of degenerating cells, deep epithelial defects, fibrin strands, surfac

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Resnerová, Karolina, Jaroslav Holuša, Peter Surový, Jiří Trombik, and Emanuel Kula. "Comparison of Ips cembrae (Coleoptera: Curculionidae) Capture Methods: Small Trap Trees Caught the Most Beetles." Forests 11, no. 12 (2020): 1275. http://dx.doi.org/10.3390/f11121275.

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Ips cembrae is the most important bark beetle pest of larches and has had several local outbreaks in recent decades in Europe. In this study, we compared the numbers of I. cembrae captured by pyramid-trap piles, trap trees, pheromone traps, and poisoned and baited tripods. We also studied how the properties of trap trees and trap logs (volume, sun exposure, and position relative to the ground once deployed) affected the trapping of I. cembrae. We found that both sexes avoided infestation at the bottom of the logs and more than 15 times the number of beetles were captured by traditional trap tr

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Zahara, Meutia, Mauizah Hasanah, and Rahma Zalianda. "Identification of Zingiberaceae as medicinal plants in Gunung Cut Village, Aceh Barat Daya, Indonesia." Journal of Tropical Horticulture 1, no. 1 (2018): 24. http://dx.doi.org/10.33089/jthort.v1i1.9.

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Zingiberaceae is well known as gingers family with abundant numbers of spices widely used in Southeast Asia, because of their unique flavors, ornamental and also the medicinal values. The extracts of Zingiberaceae rhizome contain many essentials oils, including terpenes, alcohols, ketones, flavonoids and phytoestrogens that use as medicine. Zingiberaceae grow vigorously in a wide range of habitats ranging from riverine to the limestone area, from lowland to the upper mountain regions. They often grow in shady area but some of the native species are able to tolerate to the sun exposure. The cul

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Bergfelt, L. "UV/related skin conditions and Langerhans' cell populations in human skin." Acta Dermato-Venereologica 73, no. 3 (1993): 194–96. http://dx.doi.org/10.2340/0001555573194196.

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Chronic sun exposure and cumulative exposures to PUVA are associated with a risk of development of non/melanoma skin cancer. Acute UV irradiation reduces the number of epidermal antigen/presenting Langerhans' cells in the skin. Alterations in the Langerhans' cell population could be relevant to a disturbance in the cutaneous immune response in UV/exposed skin. Therefore the density of CDla+ and ATPase+ Langerhans' cells in epidermal sheets from the hand, buttock and in some cases face was examined in PUVA/treated patients (n = 8) and in patients with actinic keratosis (n = 13) or basal cell ca

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Jimenez Sanchez, M. C., H. Yang, J. Dutz, H. Sham, and B. Vallance. "A2 UVB ON SKIN EXPOSURE MODULATES INTESTINAL HOMEOSTASIS IN MICE." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (2024): 1–2. http://dx.doi.org/10.1093/jcag/gwad061.002.

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Abstract Background Inflammatory diseases, like IBD, are on the rise in Western societies, in concert with changes in the environment, such as reduced sun exposure. Ultraviolet light (UV) B's effects on the skin include upregulating vitamin D and Aryl hydrocarbon receptor (Ahr) signalling, but its potential influence on distant sites, like the gut, are not well-studied. The gut and skin share a strong link, with some GI patients also experiencing skin diseases (O’Neill et al., 2016). We sought to understand how UVB exposure affects gut health, gut microbiota and its metabolic by-products. We h

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Skrzecz, Iwona, Maria Bulka, and Joanna Ukalska. "Effects of location of Norway spruce (Picea abies) stumps on their colonisation by insects in the mountains." Folia Forestalia Polonica 61, no. 1 (2019): 64–77. http://dx.doi.org/10.2478/ffp-2019-0007.

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Abstract Tree stumps provide habitat for insect assemblages, which are influenced by various factors. Among these factors, physical and chemical changes of the stumps, fungi developing in the dead wood and stump size are most often reported. However there is limited information about the abundance of insects in stumps that are located on mountains where there are different microclimatic conditions. The studies pointed at the determination whether the location of Picea abies stumps in mountains at different altitudes above sea level and on mountainsides with different sun exposure has an impact

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Victor, Frank C., Jeremy Gelber, and Babar Rao. "Melasma: A Review." Journal of Cutaneous Medicine and Surgery 8, no. 2 (2004): 97–102. http://dx.doi.org/10.1177/120347540400800204.

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Objective: To better understand melasma, a review of its etiologic factors, classification, pathogenesis, and treatment was undertaken. Methods: Articles discussing the above aspects of melasma were used to demonstrate what is currently known about the disease and how to treat it. Results: Melasma is associated with many etiologic factors, most importantly, sun exposure. It occurs in three distributions and has four reported patterns of pigmentation. Among the many differences between melasma and normal skin, melasma skin contains increased melanin, melanocytes, and melanosomes, as well as inc

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Seo, Bojung, Eunyoung Cho, Abrar A. Qureshi, and Jiali Han. "Abstract 6473: Association of sun-seeking behaviors with indoor tanning habit in US females." Cancer Research 83, no. 7_Supplement (2023): 6473. http://dx.doi.org/10.1158/1538-7445.am2023-6473.

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Abstract Introduction: Frequent exposure to ultraviolet in early life has more detrimental and long-term effects on skin than in adulthood. Teenagers with strong sun-seeking behaviors are more likely to use an indoor tanning bed than those who seek less sun, probably due to addictive component of ultraviolet exposure. We aimed to examine the associations between sun exposure behaviors and average annual indoor tanning usage frequency during high school/college in US females. Methods: In this cross-sectional study, we included a total of 76,122 US females who answered the average annual frequen

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Acosta, X., A. X. González-Reyes, N. D. Centeno, and J. A. Corronca. "Biological, Ecological, and Distributional Aspects of Two Native Species of Lucilia Genus (Diptera: Calliphoridae) of Forensic Interest in Yungas Environments of Argentina." Journal of Medical Entomology 57, no. 6 (2020): 1700–1711. http://dx.doi.org/10.1093/jme/tjaa126.

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Abstract This study determined the spatial and temporal dynamics of two native neotropical species flies of forensic interest, belonging to the Lucilia (Robineau-Desvoidy) genus. The study focused on their abundance and reproductive behaviors associated with different habitats and phenological parameters. In the Province of Salta, Argentina, monthly samplings were performed over 1 yr in urban, rural, and native habitats, at morning, mid-day, and afternoon periods, controlling the oviposition of captured specimens. Environmental variables were also assessed: cloudiness, precipitation, relative

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Saini, Natalie, Camille K. Giacobone, Leszek J. Klimczak, et al. "UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin." PLOS Genetics 17, no. 1 (2021): e1009302. http://dx.doi.org/10.1371/journal.pgen.1009302.

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Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the somatic mutation load in the skin of healthy humans has so far not been accurately assessed because the low numbers of mutations from current sequencing methodologies preclude the distinction between sequencing errors and true somatic genome changes. In this work, we sequenced genomes of single cell-

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Fowler, Joanna, George Coltart, Roshan Sood, et al. "P07 Mutagenicity of narrowband ultraviolet B." British Journal of Dermatology 190, no. 6 (2024): e82-e82. http://dx.doi.org/10.1093/bjd/ljae105.029.

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Abstract Introduction and aims Exposure to ultraviolet (UV) radiation causes DNA mutations in skin and development of skin cancer. Despite this, UV radiation in the form of narrowband UVB is commonly used by dermatologists to treat skin diseases such as psoriasis. However, the mutagenicity of narrowband UVB in human skin is unknown. In this study, we investigated the mutation burden resulting from a course of narrowband UVB in patients with psoriasis. Methods Skin biopsies were taken from uninvolved skin of sixteen patients with psoriasis before and after a treatment course of narrowband UVB.

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Holovach, Phillip G., Wei-Wen Hsu, and Alan B. Fleischer. "Number Bias in Clinicians’ Documentation of Actinic Keratosis Removal." Journal of Clinical Medicine 13, no. 1 (2023): 202. http://dx.doi.org/10.3390/jcm13010202.

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Background: Actinic keratosis (AK) is a pre-cancerous skin condition caused by sun exposure. Number bias, a phenomenon that occurs when meaning other than numerical value is associated with numbers, may influence the reporting of AK removal. The present study aims to determine if number bias is affecting healthcare providers’ documentation of patient-provider encounters. Methods: A single-center retrospective chart review of 1415 patients’ charts was conducted at the University of Cincinnati Medical Center. To determine if there was a significant difference between even and odd-numbered AK rem

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Khan, Hammad, Zain Ul Abideen, Muhammad Hamza Shafqat, and Muhammad Adeel Ashraf. "Drawbacks of sunscreens on the cutaneous synthesis of Vitamin D." Journal of the Pakistan Medical Association 75, no. 04 (2025): 681. https://doi.org/10.47391/jpma.21965.

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Madam, During sun exposure, the sun-emitted UVB photons with wavelength range of 290-315nm are absorbed by 7-dehydrocholesterl (also known as pro-vitamin D3) in the epidermis and dermis to form pre-vitamin D3 which is then converted to vitamin D3. Cutaneous synthesis of vitamin D induced by sunlight is subjected to significant variations based on the season, hour of the day, altitude, skin color, sunscreen application and aging. Vitamin D is then processed further in the liver to form 25-hydroxyvitamin D and then in the kidneys by the action of 1a-hydroxylase that converts vitamin D into its a

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Grant, Sydney R., Megan E. Fitzgerald, Barbara A. Foster, Wendy J. Huss, Lei Wei, and Gyorgy Paragh. "Abstract 1909: Comparison of mutational burden hotspots in cutaneous squamous cell carcinoma and UV-exposed healthy skin for development of optimal targeted sequencing panels." Cancer Research 82, no. 12_Supplement (2022): 1909. http://dx.doi.org/10.1158/1538-7445.am2022-1909.

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Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common human malignancy in the United States. Chronic long-term ultraviolet (UV) exposure drives cSCC development. Early clonal mutation (CM) accumulation is the first step in photocarcinogenesis and is the first known manifestation of field cancerization. Understanding CM accumulation and development is expected to improve the prevention of field cancerization and cSCC. Nevertheless, CMs are poorly understood, and mutations in cSCC have yet to be systematically compared to CM in sun-exposed skin. Key steps for studies to det

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Amadou, Nafissatou Mahamadou, and Ali Doumma. "Effet de la préexposition au soleil et du prétraitement au froid, sur l’évolution des populations de bruches dans les systèmes de stockage traditionnels des graines niébé (Vigna unguiculata(L.) Walp.) au Niger." International Journal of Biological and Chemical Sciences 15, no. 6 (2022): 2625–35. http://dx.doi.org/10.4314/ijbcs.v15i6.29.

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Le niébé, Vigna unguiculata (L.) Walp., est la principale légumineuse alimentaire cultivée en Afrique de l’Ouest. Cependant la difficulté de conservation post récolte des graines limite sa production et sa disponibilité en toute saison. En effet, plusieurs espèces de Coléoptères bruchinae, dont Callosobruchus maculatus Fab est la plus importante, se développent dans les graines de niébé en causant des pertes substantielles. L’infestation débute dans les champs, et se poursuit dans les stocks où les dégâts peuvent être considérables si aucune mesure de protection n’est prise. Les producteurs de

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Cohen, Jeffrey I., Irini Manoli, Kennichi Dowdell, et al. "Hydroa vacciniforme–like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in whites." Blood 133, no. 26 (2019): 2753–64. http://dx.doi.org/10.1182/blood.2018893750.

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AbstractPatients with classic hydroa vacciniforme–like lymphoproliferative disorder (HVLPD) typically have high levels of Epstein-Barr virus (EBV) DNA in T cells and/or natural killer (NK) cells in blood and skin lesions induced by sun exposure that are infiltrated with EBV-infected lymphocytes. HVLPD is very rare in the United States and Europe but more common in Asia and South America. The disease can progress to a systemic form that may result in fatal lymphoma. We report our 11-year experience with 16 HVLPD patients from the United States and England and found that whites were less likely

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Nafisa Kusumawati and Ignatius Sudaryadi. "Effect of Feeding Kiwifruit (Actinidia deliciosa) Extract on Survival Rate and Reproductive Organ Morphology of Fruit Fly (Drosophila melanogaster Meigen, 1830) Ultraviolet Light Irradiation." Berkala Ilmiah Biologi 13, no. 3 (2022): 9–18. http://dx.doi.org/10.22146/bib.v13i3.5215.

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UV (ultraviolet) radiation is one of the radiations that are naturally emitted by the sun. As the result of climate changes, the earth's ozone layer changes and the UV light radiation to the earth's surface increases. The negative effect of UV radiation is increase due to the production of ROS (Reactive Oxygen Species) or free radicals in the body. UV radiation protection can be done by increasing the intake of antioxidant-rich foods as free radical inhibitors. Actinidia deliciosa or kiwifruit is a antioxidants-rich fruit including vitamin C. This research was carried out with Drosophila melan

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Geidel, Paula, Josephine Tabea Tauer, Nadine Steinbronn, et al. "Cardiac Failure In Juvenile Rats Caused By Continuous Long-Term Exposure To The Tyrosine Kinase Inhibitor Dasatinib Can Be Circumvented By An Intermittent Application Schedule." Blood 122, no. 21 (2013): 3984. http://dx.doi.org/10.1182/blood.v122.21.3984.3984.

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Abstract Background Treatment of chronic myeloid leukemia (CML) by tyrosine kinase inhibitors (TKIs, e.g. imatinib, dasatinib) can result in cardiac failure as these drugs exert off-target effects via so far ill-defined mechanisms. Especially in pediatric patients long-term drug exposure is of great concern as this cohort may require life-long treatment for CML. Dasatinib-induced side effects require treatment interruption or dose modification in particular due to hematologic toxicity or cardiac and pleural effusions. Here we investigated the impact of prolonged dasatinib exposure on the growi

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Saleh, Fatma, Jovin Kitau, Flemming Konradsen, Ayubo Kampango, Rahibu Abassi, and Karin Linda Schiøler. "Epidemic risk of arboviral diseases: Determining the habitats, spatial-temporal distribution, and abundance of immature Aedes aegypti in the Urban and Rural areas of Zanzibar, Tanzania." PLOS Neglected Tropical Diseases 14, no. 12 (2020): e0008949. http://dx.doi.org/10.1371/journal.pntd.0008949.

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Background In Zanzibar, little is known about the arboviral disease vector Aedes aegypti in terms of abundance, spatio-temporal distribution of its larval habitats or factors associated with its proliferation. Effective control of the vector requires knowledge on ecology and habitat characteristics and is currently the only available option for reducing the risk of arboviral epidemics in the island nation of Zanzibar. Methodology We conducted entomological surveys in households and surrounding compounds from February to May 2018 in the urban (Mwembemakumbi and Chumbuni) and rural (Chuini and K

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Bidoli, Ettore, Silvia Franceschi, Lorenzo Simonato, et al. "Differences in Cancer Mortality Trends between Four Neighboring North-Eastern Areas and Italy, 1970-1990." Tumori Journal 81, no. 6 (1995): 399–404. http://dx.doi.org/10.1177/030089169508100602.

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Aims and background The present report combines descriptive statistics (partly never published) on four neighboring areas of north-eastern (NE) Italy [Friuli-Venezia Giulia (1970-89) and Veneto (1970-87) regions and the provinces of Trento (1970-89) and Bolzano (1971-90)], and all Italy (1970-89). The aim was to highlight potential differences in mortality trends and promote a more systematic sharing of data and methodologies. Methods Death certificates stratified by cause, sex, age and residence were obtained from official publications of the Italian Central Institute of Statistics. Absolute

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Ali, Naureen, and Fakhriya Alalawi. "Vitamin D Status and SLE Disease Activity among Dubai Hospital Lupus Patients." European Journal of Clinical Medicine 4, no. 2 (2023): 18–24. http://dx.doi.org/10.24018/clinicmed.2023.4.2.251.

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Background: Vitamin D deficiency is common worldwide, but is particularly prevalent in the Middle Eastern region, where cultural and religious factors influence its incidence further. As patients with Systemic Lupus Erythematosus (SLE) avoid sun exposure and use medications that could potentially result in vitamin D deficiency, this problem becomes more apparent. Unfortunately, there are no data available on the prevalence of vitamin D deficiency among patients with SLE in our local area. Objective: To assess the prevalence of vitamin D deficiency among patients with a new onset of systemic lu

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Gottlieb, A. B., J. F. Merola, A. Armstrong, et al. "AB0528 COMPARABLE SAFETY PROFILE OF GUSELKUMAB IN PSORIATIC ARTHRITIS AND PSORIASIS: RESULTS FROM PHASE 3 TRIALS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1293–94. http://dx.doi.org/10.1136/annrheumdis-2021-eular.556.

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Background:DISCOVER 1&2 (PsA) and VOYAGE 1&2 (PsO) are Phase 3 trials of guselkumab (GUS).Objectives:Compare safety results through up to 1yr of GUS in PsA and PsO pts.Methods:In DISCOVER, 1120 pts with active PsA despite standard therapy were treated. Most pts were biologic-naïve; ~30% in DISCOVER 1 had previous exposure to 1-2 TNFi. Concomitant MTX (57%), oral corticosteroids (17%), and NSAIDs (64%) were permitted. Pts were randomized to SC GUS 100mg at W0, W4, then Q8W; GUS 100mg Q4W; or PBO. At W24, PBO patients were switched to GUS 100mg Q4W. In VOYAGE, in which concomitant MTX us

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Shiuan, Eileen F., Lu Sun, Jeremy Reynoso, et al. "Abstract B032: Immune landscape of resected brain metastases in patients treated with and without immune checkpoint blockade immunotherapy." Cancer Research 83, no. 2_Supplement_2 (2023): B032. http://dx.doi.org/10.1158/1538-7445.metastasis22-b032.

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Abstract Background: The brain metastatic niche has been historically difficult to study and thus poorly understood. Although brain metastases portend high morbidity and mortality, increasing evidence has shown that immune checkpoint blockade (ICB) can confer long-lasting responses in patients. How ICB remodels the brain tumor microenvironment is still relatively unknown. Here, we examine the immune microenvironment of resected brain metastases in a cohort of 19 patients pre-operatively treated with and without ICB using single-cell methods. Methods: Tumor tissue was obtained from patients who

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Clynes, R., C. Key, Y. Ding, et al. "POS0119 XmAb564, A NOVEL POTENCY-REDUCED IL-2 FC FUSION PROTEIN SELECTIVELY EXPANDS REGULATORY T CELLS: RESULTS FROM A SINGLE ASCENDING DOSE STUDY IN HEALTHY ADULT VOLUNTEERS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 275.1–275. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2868.

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BackgroundInterleukin 2 (IL-2) signaling is essential for the development, survival, and suppressive function of T regulatory cells (Tregs). Diminished IL-2 signaling and Treg functional impairment are associated with autoimmune diseases, including systemic lupus erythematosus (SLE)[1]-[3]. XmAb564 is a potency reduced, monomeric human IL-2 heterodimeric Fc-fusion protein with extended half-life and increased binding affinity for IL-2 receptor alpha (CD25) to selectively expand Tregs, being developed for the treatment of autoimmune diseases.ObjectivesIn this first-in-human, placebo-controlled,

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Ahmed, Muna, Salah M. R, and IMT Fadlalla. "Occupational hazards, disease symptoms and physiological responses in workers with different workloads under out and indoor conditions." International Journal of Advance Research in Education & Literature (ISSN 2208-2441) 11, no. 1 (2025): 78–103. https://doi.org/10.61841/kt3ymd71.

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The present research work was carried during the period of January 2012 – January 2013 with the objective to assess the impact of thermal environment (indoors/outdoors) on the health workers carrying different workloads (heavy, moderate, light). The outdoor study targeted subjects working in building construction in Khartoum. The indoor study targeted subjects working in textile and glassware factories in Khartoum industrial area. The control subjects were selected from those employed at the National Health Laboratory. A questionnaire was designed to obtain information about workers pertaining

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Lemar, Hadia, Anmol Vohra, Ming-Hong Xie, Ivan Chan, Sasha Lazetic, and James Trager. "128 KIR haplotype can inform donor selection production of allogeneic memory-like CAR NK cells for clinical application." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A137. http://dx.doi.org/10.1136/jitc-2021-sitc2021.128.

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BackgroundNK cells expanded on membrane-bound (mb) IL-15 and 41BBL expressing K562 stimulatory cells (NKSTIM) for clinical use can be genetically modified to express activating chimeric receptors.1 2 3 NK cells activated in the presence of IL-12, IL-15 and IL-18 develop cytokine induced memory-like (CIML) phenotype and function; these cells have shown clinical promise.4 Additionally, HSCT AML transplants using NK KIR Haplotype Group B donors with better and best Group B profiles (≥2 activating genes) show better survival.5 6 Here we investigate whether KIR profiles impact healthy allogeneic do

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Heitkämper, Tim, Raphael Roth, Stephan Harteneck, et al. "Flying microbes—survival in the extreme conditions of the stratosphere during a stratospheric balloon flight experiment." Microbiology Spectrum, June 13, 2024. http://dx.doi.org/10.1128/spectrum.03982-23.

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ABSTRACT Earth’s stratosphere is characterized by hypobaric conditions, low temperatures, and high intensities of ultraviolet (UV) and cosmic radiation as well as low water and nutrient availability. While it is not considered a permanent habitat for microorganisms, they can be transported to the stratosphere by storms, volcanic action, or human activity. The impact of those extreme conditions on microorganisms and their survival were tested by sending a sample gondola to the stratosphere. The sample gondola was built to allow exposure of Bacillus subtilis endospores at different angles to the

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van Bodegraven, Mirja, Marius Kröger, Daniela F. Zamudio Díaz, et al. "Redefine photoprotection: Sun protection beyond sunburn." Experimental Dermatology 33, no. 1 (2024). http://dx.doi.org/10.1111/exd.15002.

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AbstractExcessive exposure to ultraviolet (UV) light leads to acute and chronic UV damage and is the main risk factor for the development of skin cancer. In most countries with western lifestyle, the topical application of sunscreens on UV‐exposed skin areas is by far the most frequently used preventive measure against sunburn. Further than preventing sunburns, increasing numbers of consumers are appreciating sunscreens with a medium‐ to high‐level sun protective factor (SPF) as basis for sustainable‐skin ageing or skin cancer prevention programs. However, recent investigations indicate that c

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Sbaraglia, Claudio, Simon Thorn, Lucie Ambrožová, et al. "Sun exposure as a main driver influencing the arriving communities of saproxylic beetles on deadwood." Ecological Entomology, January 31, 2025. https://doi.org/10.1111/een.13428.

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Abstract The ability to locate and colonise ephemeral deadwood resources is crucial to saproxylic beetle assemblages. Saproxylic beetles locate suitable substrates mainly through visual cues and via olfactory cues emitted by deadwood, other insects and fungi. For the conservation of saproxylic beetles, it is essential to understand which abiotic and biotic factors most significantly influence their habitat requirements when locating suitable substrates. In a field experiment, in sunny and shaded plots, we exposed 400 bundles of freshly cut deadwood, each consisting of three logs with a combina

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Knipping, Sofie, Elke Ter Haar, Hans Alkemade, et al. "Translation and Validation of the Dutch Version of the Sun Exposure and Protection Index (SEPI)." Dermatology, November 27, 2023. http://dx.doi.org/10.1159/000535510.

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Introduction: Skin cancer is currently the most common cancer type worldwide, and numbers are rapidly increasing. To improve primary prevention, individualised prevention strategies may be of interest as this enhances the chance of long-term behavioural change. The Sun Exposure and Protection Index (SEPI), previously validated in multiple languages, is a tool that could help identify individuals with risky behaviour and tailor interventions to the person’s propensity to change. The aim of the present study was to investigate the reliability and validity of a Dutch version of the SEPI for both

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Sampat, Neela A., Mohammed AlRizeiqi, Musthafa Mohamed Essa, Lyutha Al-Subhi, Samir Al-Adawi, and M. Walid Qoronfleh. "Assessing General Knowledge and Nutritional Knowledge on the Role of Vitamin D, Attitudes, and Behavior Toward Sun Exposure Among Tertiary Students in Oman." Advances in Public Health 2024, no. 1 (2024). http://dx.doi.org/10.1155/2024/9544155.

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Background: Vitamin D deficiency is highly prevalent among the Omani population, driven by factors such as urbanization, technology‐driven lifestyles, reduced physical activity, limited sun exposure, unhealthy eating habits, and genetic predispositions. Despite the year‐round availability of sunlight, there is limited understanding of the specific causes of this deficiency and effective strategies to mitigate it.Aim: This study aimed to develop and validate a knowledge, attitude, and practice (KAP) questionnaire on vitamin D and measure the KAP levels among students at Sultan Qaboos University

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Brustad, Magritt, and Haakon E. Meyer. "Vitamin D – a scoping review for Nordic nutrition recommendations 2023." Food & Nutrition Research, November 13, 2023. http://dx.doi.org/10.29219/fnr.v67.10230.

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Vitamin D is an essential nutrient. Its role in calcium and phosphorous metabolism, and in the development and maintenance of a healthy skeleton is well documented. In addition, there is some evidence for vitamin D decreasing total mortality and cancer mortality modestly, but not cancer incidence. Vitamin D is unique, as both diet and sun induced production in skin are sources to this vitamin. Individual vitamin D status is thus a sum of both sun exposure and dietary intakes. The discovery of vitamin D receptors and the activation of biological active vitamin D in numerous tissues and organs i

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Spyra, Aneta. "Environmental factors influencing the occurrence of freshwater snails in woodland water bodies." Biologia 65, no. 4 (2010). http://dx.doi.org/10.2478/s11756-010-0063-1.

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AbstractStudies were carried out in eight woodland water bodies that are situated in an urbanised area of Southern Poland (Upper Silesia). The aim of this study was to determine the influence of auto- and allochthonous plant detritus and exposure to sunlight on the structure of snail communities in woodland ponds. Among some physico-chemical water parameters, pH influenced the occurrence of snails, whereas sunlight caused an increase in diversity of the snail communities. In the total snail collection, 72.1% of specimens were gathered in sun-exposed sites. By the same degree of insolation more

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Al Ghafri, Mohammed, Hamed Al Qanobi, Asma Al Shidhani, Abdulaziz Al Mahrezi, and Salah Al Awaidy. "Status of vitamin D deficiency among adult population presented to primary health care: A retrospective cross-sectional study." Qatar Journal of Public Health 2025, no. 2 (2025). https://doi.org/10.5339/qjph.2025.2.

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Introduction: Vitamin D insufficiency is on the increase globally, becoming a significant public health concern even in nations with abundant access to sunshine and food. Although Oman enjoys extended periods of sunshine, the prevalence of vitamin D deficiency has lately increased. The study aims to assess the levels of vitamin D in the adult Omani citizen population who sought primary healthcare in Oman. Methods: We conducted a retrospective cross-sectional study in Muscat, Oman, between January and December 2015, involving 250 primary health care users aged 18 years or older who had a 25-hyd

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Ghose, Soumya, Yingnan Ju, Elizabeth McDonough, et al. "3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging." Communications Biology 6, no. 1 (2023). http://dx.doi.org/10.1038/s42003-023-04991-z.

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AbstractMapping the human body at single cell resolution in three dimensions (3D) is important for understanding cellular interactions in context of tissue and organ organization. 2D spatial cell analysis in a single tissue section may be limited by cell numbers and histology. Here we show a workflow for 3D reconstruction of multiplexed sequential tissue sections: MATRICS-A (Multiplexed Image Three-D Reconstruction and Integrated Cell Spatial - Analysis). We demonstrate MATRICS-A in 26 serial sections of fixed skin (stained with 18 biomarkers) from 12 donors aged between 32–72 years. Comparing

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Muhammad, Abdullah Khurram. "VITAMIN D DEFICIENCY IN CHILDREN AND ITS MANAGEMENT." o6, no. 06 (2019): 12211–16. https://doi.org/10.5281/zenodo.3250300.

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<em>Vitamin D IS a prohormone that is essential for normal absorption of calcium from the gut, and deficiency of vitamin D is associated with rickets in growing children and osteomalacia in adults. Rickets is the lack of mineralization ability of growing bone and cartilage. At the turn of the 20th century, with industrialization, this disease became endemic until it was discovered that exposure to sunlight and cod liver oil could both prevent and treat rickets. Once vitamin D was identified and easy ways to supplement foods were developed, nutritional rickets almost disappeared from industrial

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Parodi, G., R. de Souza Santos, G. Leite, et al. "SUN-477 The Gut Microbe Rothia Mucilaginosa Induces a Polycystic Ovarian Syndrome-Like Phenotype in a Rat Model." Journal of the Endocrine Society 8, Supplement_1 (2024). https://doi.org/10.1210/jendso/bvae163.2430.

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Abstract G. Parodi: None. R. de Souza Santos: None. G. Leite: None. F. Medeiros: None. G.M. Barlow: None. W. Morales: None. S.R. Weitsman: None. M. Sanchez: None. I. Rivera: None. M. Villanueva-Millan: None. F. Faria: None. D. Flor: None. L. Choi: None. M. Pimentel: None. R. Mathur: None. Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting ∼12% of reproductive-age women. Its clinical signatures include hyperandrogenism, ovarian dysfunction, infertility, and insulin resistance. We hypothesize that bacterial testosterone (T) biosynthesis is a source of excess T in PCOS. The small

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Patra, VijayKumar, Johanna Strobl, Denise Atzmüller, et al. "Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption." Frontiers in Medicine 9 (June 10, 2022). http://dx.doi.org/10.3389/fmed.2022.908047.

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Patients with polymorphic light eruption (PLE) develop lesions upon the first exposure to sun in spring/summer, but lesions usually subside during season due to the natural (or medical) photohardening. However, these lesions tend to reappear the following year and continue to do so in most patients, suggesting the presence of a disease memory. To study the potential role of skin resident memory T cells (Trm), we investigated the functional phenotype of Trm and the expression of IL-15 in PLE. IL-15 is known to drive Trm proliferation and survival. Multiplex immunofluorescence was used to quanti

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Devaraj, Yogesh, Priyanka Yogananda, Nikitha Reddy, Taranpreet Kaur Kalra, and Sheik Mohammad Obeidullah. "CLINICO EPIDEMIOLOGICAL PROFILE OF FACIAL MELANOSIS IN A RURAL TERTIARY CARE HOSPITAL - A CROSS SECTIONAL STUDY." PARIPEX INDIAN JOURNAL OF RESEARCH, December 15, 2023, 96–99. http://dx.doi.org/10.36106/paripex/7306441.

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Introduction: Facial melanosis is a group of pigmentary disorders characterised by altered pigmentation occurring over the face. Genetic, environmental and hormonal factors play a crucial role in the pathogenesis of these disorders. They cause cosmetic disfigurement and negative psychosocial impact especially among females. To det Aims: ermine the epidemiological factors and clinical patterns of various types of facial hypermelanosis. A Materials And Methods: cross-sectional observational study conducted over a period of 18 months in a rural tertiary care hospital. All patients presenting with

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Farid, Menaa. "Viral Etiology of Merkel Cell Carcinoma:Implications in Diagnosis, Prognosis, Therapy and Prevention." April 15, 2015. https://doi.org/10.19070/2332-2977-150002e.

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Merkel cell carcinoma (MCC) is a rare and a highly aggressive skin cancer of neuroendocrine origin that is frequently associated with a poor prognosis, a clonal integration of a polyomavirus (MCPyV), and a high propensy for recurrence and metastasis; its incidence increases with age, immunodeficiency and sun exposure [2, 4, 5, 6, 8]. Importantly, cytokeratin 20 (CK20) is expressed in approximately 95% of MCC cases, MCPyV in about 80% of cases, and MCPyV is less common in CK20-negative MCC [6]. The disease progression could be evaluated by means of high numbers of mitoses, proliferation and sur

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Park, Su-Jin, Junyoung Park, Doil Kim, et al. "The first mobile photon-counting detector CT: the human images and technical performance study." Physics in Medicine & Biology, March 29, 2023. http://dx.doi.org/10.1088/1361-6560/acc8b3.

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Abstract Objective: The purpose of this study is to assess its human images and its unique capabilities such as the “on demand” higher spatial resolution and multi-spectral imaging of photon-counting-detector (PCD)-CT. &#xD;Approach: In this study, the FDA 510(k) cleared mobile PCD-CT (OmniTom Elite) was used. To this end, we imaged internationally certified CT phantoms and a human cadaver head to evaluate the feasibility of high resolution and multi-energy imaging. We also demonstrate the performance of PCD-CT via first-in-human imaging by scanning three human volunteers. &#xD;Main re

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