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Journal articles on the topic 'Sun Yat-sen Memorial Association'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Sun, Kan, Chengzhi Wang, Guojuan Lao, et al. "Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China." BMJ Open 10, no. 2 (2020): e033991. http://dx.doi.org/10.1136/bmjopen-2019-033991.

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ObjectivesHypogonadism in men is related to the deterioration of general health. However, the association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed to provide an insight into the possible links between the lipid accumulation product (LAP) and late-onset hypogonadism (LOH).SettingSun Yat-sen Memorial Hospital of Sun Yat-sen University.ParticipantsWe included a population sample of 997 subjects aged 40 years or older.Primary and secondary outcome measuresThe LAP was calculated by gender-specific equations using waist circumference (W

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Hong, Xiaosi, Xiaoyun Zhang, Lili You, et al. "Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study." BMJ Open 13, no. 2 (2023): e060377. http://dx.doi.org/10.1136/bmjopen-2021-060377.

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ObjectivesAdiponectin is closely related to glucose metabolism and traditional diabetes risk factors (obesity, hypertension and dyslipidaemia). We aimed to explore the association between adiponectin levels and newly diagnosed type 2 diabetes mellitus (T2DM) and pre-diabetes in subgroups classified according to T2DM risk factors.SettingSun Yat-sen Memorial Hospital of Sun Yat-sen University.Participants3680 individuals (1753 men and 1927 women) aged 18–70 years from Guangzhou and Dongguan, China, were enrolled from December 2018 to October 2019.Primary and secondary outcome measuresT2DM was de

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Thapa, Ashish, Bing-Xi Lei, Mei-Guang Zheng, Zhong-Jun Li, Zheng-Hao Liu, and Yue-Fei Deng. "The Surgical Treatment of Posttraumatic Skull Base Defects with Cerebrospinal Fluid Leak." Journal of Neurological Surgery Part B: Skull Base 79, no. 02 (2017): 205–16. http://dx.doi.org/10.1055/s-0037-1606555.

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Objectives The objective was to explore further the surgical treatment of posttraumatic skull base defects with cerebrospinal fluid (CSF) leak and to identify the most common factors affecting the surgical treatment of posttraumatic skull base defect with CSF leak retrospectively. Materials and Methods This study included 144 patients with head trauma having skull base defect with CSF leak who had been surgically treated at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University from 1998 to June 2016. There were 113 (78.5%) males and 31 (21.5%) females, with age ranging from 1 to 78 years and

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Cai, Yuexin, Qian Zhou, Haidi Yang, et al. "Logistic regression analysis of factors influencing the effectiveness of intensive sound masking therapy in patients with tinnitus." BMJ Open 7, no. 11 (2017): e018050. http://dx.doi.org/10.1136/bmjopen-2017-018050.

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ObjectivesTo investigate factors influencing the effectiveness of intensive sound masking therapy on tinnitus using logistic regression analysis.DesignThe study used a retrospective cross-section analysis.Participants102 patients with tinnitus were recruited at the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, China.InterventionIntensive sound masking therapy was used as an intervention approach for patients with tinnitus.Primary and secondary outcome measuresParticipants underwent audiological investigations and tinnitus pitch and loudness matching measurements, followed by intensi

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Li, Wenpeng, Lexiang Zeng, Deping Han, et al. "Development of a preoperative index-based nomogram for the prediction of hypokalemia in patients with pituitary adenoma: a retrospective cohort study." PeerJ 9 (July 19, 2021): e11650. http://dx.doi.org/10.7717/peerj.11650.

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Objective To develop and validate a preoperative index-based nomogram for the prediction of hypokalemia in patients with pituitary adenoma (PA). Methods This retrospective cohort study included 205 patients with PAs between January 2013 and April 2020 in the Sun Yat-sen Memorial Hospital, Guangzhou, China. The patients were randomly classified into either a training set (N = 143 patients) and a validation set (N = 62 patients) at a ratio of 7:3. Variables, which were identified by using the LASSO regression model were included for the construction of a nomogram, and a logistic regression analy

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Zhou, Xuezhen, Xi Lin, Runnan Shen, et al. "A retrospective analysis of risk factors associated with catheter-related thrombosis: a single-center study." Perfusion 35, no. 8 (2020): 806–13. http://dx.doi.org/10.1177/0267659120915142.

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Background: Catheter-related thrombosis may lead to catheter infections and failure, further deep venous thrombosis, and pulmonary embolism. Recognizing the risk factors for catheter-related thrombosis is extremely important to inform the development of catheter care guidelines. Methods: Data were collected from a total of 1,532 patients who had undergone venous catheterization, including indwelling catheterization from 19 March 2019 to 30 March 2019 in the Sun Yat-sen Memorial Hospital. The factors for which data were to be collected included the patients’ physical characteristics, catheter-r

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Long, Miaoyun, Yunfang Yu, Lili Lin, et al. "Abstract 5265: Novelmolecular subtypes of papillary thyroid carcinoma (PTC) driven by BRAFV600E-,RAS- and RET-mutations linked to distinct clinicopathological features and tumor immune microenvironment." Cancer Research 82, no. 12_Supplement (2022): 5265. http://dx.doi.org/10.1158/1538-7445.am2022-5265.

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Abstract Background: PTC is the most common type of thyroid cancer and offers excellent prognosis. However, recurrence PTC remains relatively common, especially PTC with BRAF V600E mutation. PTC is often characterized by RET, RAS or BRAFmutations. RAS, RET and BRAF V600E mutations tend to be mutually exclusive. In this study, we investigated whether these oncogenic driver mutations could propose a molecular classification of PTC into distinct tumor immune microenvironment. Methods: Surgical tissue samples from 252 patients with stage I-III PTC consecutively diagnosed between 07/2020 to 08/2021

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Gu, Linqiang, and Weixin Lin. "Influence of music performance on Sun Yat-sen Memorial Hall." Journal of the Acoustical Society of America 131, no. 4 (2012): 3510. http://dx.doi.org/10.1121/1.4709267.

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ICHIKAWA, Koji. "STUDY ON MEMORIAL ACTIVITIES FOR SUN YAT-SEN IN MODERN BEIJING." Journal of Architecture and Planning (Transactions of AIJ) 83, no. 751 (2018): 1791–99. http://dx.doi.org/10.3130/aija.83.1791.

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Jianli, Huang, and Hong Lysa. "History and the Imaginaries of ‘Big Singapore’: Positioning the Sun Yat Sen Nanyang Memorial Hall." Journal of Southeast Asian Studies 35, no. 1 (2004): 65–89. http://dx.doi.org/10.1017/s0022463404000049.

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The establishment of the Sun Yat Sen Nanyang Memorial Hall marks the PAP government's charting of a revolutionary, modernising genealogy of seismic proportions for the fashioning of a ‘Big Singapore’ as the political, economic and cultural focus of the Chinese diaspora. Such effort in reorienting history is problematic and the ethnicisation of national identity is contested, not least by Singapore's Chinese-language intellectuals.

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Hu, Tingting, Shunrong Li, Heng Huang, et al. "Multicentre, randomised, open-label, non-inferiority trial comparing the effectiveness and safety of ductal lavage versus oral corticosteroids for idiopathic granulomatous mastitis: a study protocol." BMJ Open 10, no. 10 (2020): e036643. http://dx.doi.org/10.1136/bmjopen-2019-036643.

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IntroductionThe ideal treatment for idiopathic granulomatous mastitis (IGM) remains unclear. In a prospective, single-centre, pilot study, we reported that ductal lavage treatment for non-lactational mastitis patients had a 1-year clinical complete response (cCR) rate of >90%, without any significant adverse events. Thus, in this multicentre, randomised, open-label, non-inferiority trial, we will aim to compare the effectiveness and safety of ductal lavage vs oral corticosteroids as the first-line treatment for patients with IGM.Methods and analysisThe trial will be conducted at the Breast

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Lin, Jian-Zi, Yingying Zhu, Qian-Hua Li, et al. "Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study." BMJ Open 15, no. 7 (2025): e092583. https://doi.org/10.1136/bmjopen-2024-092583.

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Introduction The burden of rheumatoid arthritis (RA) is profound, although treated with the treat-to-target strategy for RA patients according to the two most influential organisations for rheumatology worldwide. The need to timely achieve the control of disease activity for RA patients, especially for those difficult-to-treat individuals, is still unmet. Besides, the data on the diagnosis and prognosis of RA-related complications or comorbidities such as sarcopenia, cardiovascular diseases (CVD), malignancies and infections in large real-world cohorts are still limited. Therefore, the aim of

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Zhao, Jianli, Zhixian Sun, Yunfang Yu, et al. "Radiomic and clinical data integration using machine learning predict the efficacy of anti-PD-1 antibodies-based combinational treatment in advanced breast cancer: a multicentered study." Journal for ImmunoTherapy of Cancer 11, no. 5 (2023): e006514. http://dx.doi.org/10.1136/jitc-2022-006514.

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BackgroundImmune checkpoint inhibitors (ICIs)-based therapy, is regarded as one of the major breakthroughs in cancer treatment. However, it is challenging to accurately identify patients who may benefit from ICIs. Current biomarkers for predicting the efficacy of ICIs require pathological slides, and their accuracy is limited. Here we aim to develop a radiomics model that could accurately predict response of ICIs for patients with advanced breast cancer (ABC).MethodsPretreatment contrast-enhanced CT (CECT) image and clinicopathological features of 240 patients with ABC who underwent ICIs-based

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Yang, Yaping, Fengxia Gan, Wenqian Yang, Yuan Xia, Qiang Liu, and Chang Gong. "Abstract PO2-17-03: Patient reported outcomes (PROs) and survival with toremifene versus aromatase inhibitors (AI) in patients with moderate/high-risk premenopausal hormone receptor (HR)-positive breast cancer: A real-world study." Cancer Research 84, no. 9_Supplement (2024): PO2–17–03—PO2–17–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-17-03.

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Abstract Background: The selective estrogen receptor modulator (SERM) toremifene, a synthetic analogue of tamoxifen, has shown similar efficacy to tamoxifen in patients with HR-positive breast cancer and is widely used in China for the treatment of premenopausal women with breast cancer. Multiple studies have confirmed the benefit of ovarian function suppression (OFS) combined with AI and SERMs in premenopausal women with HR-positive breast cancer. However, to date, there are no data comparing the efficacy and safety of toremifene plus OFS versus AI plus OFS. In this real-world study, we compa

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Mao, Kai, Ruomei Wang, Qiaodong Xu, et al. "Role of primary tumor resection in the prognosis of patients with resectable metastatic hepatocellular carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15642-e15642. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15642.

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e15642 Background: Patients with metastatic hepatocellular carcinoma (HCC) are diagnosed more frequently because of introduction of increasingly sensitive imaging modalities. The majority of these patients die of progressive intrahepatic tumor but not due to extrahepatic metastasis. There has been little information about the role of primary tumor resection (PTR) for metastatic HCC patients with resectable primary tumor. Methods: Metastatic HCC patients recommended PTR were identified in SEER registry between 2004 and 2013. The effect of PTR on overall and cancer-specific survival (OS and CSS)

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Wang, Yuepeng, Yukai Zheng, Zuozhen Wen, Yuwei Zhou, Yan Wang, and Zhiquan Huang. "Effects of frailty on patients undergoing head and neck cancer surgery with flap reconstruction: a retrospective analysis." BMJ Open 12, no. 12 (2022): e062047. http://dx.doi.org/10.1136/bmjopen-2022-062047.

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ObjectivesTo establish the implications of frailty as a predictor of outcome in patients with head and neck cancer requiring flap repair.DesignRetrospective cohort.Data sourceWe captured data from patients above 60 years old undergoing head and neck tumour resection and free flap reconstruction surgery between June 2019 and June 2020 at the Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. The data contain all treatment information.Outcome variablesSurgery repeated in 30 days, postoperative complications, hospital length of stay, postoperative

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Hao, Meihua, Feng Yuan, Chenchen Jin, et al. "Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome." Endocrinology 157, no. 10 (2016): 3709–18. http://dx.doi.org/10.1210/en.2016-1234.

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Polycystic ovary syndrome (PCOS) progression involves abnormal insulin signaling. SH2 domain-containing adaptor protein (Lnk) may be an important regulator of the insulin signaling pathway. We investigated whether Lnk was involved in insulin resistance (IR). Thirty-seven women due to receive laparoscopic surgery from June 2011 to February 2012 were included from the gynecologic department of the Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University. Samples of polycystic and normal ovary tissues were examined by immunohistochemistry. Ovarian cell lines underwent insulin stimulation and Lnk ove

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Jiang, Guang-Yi, Fang-Cheng Li, Wen-Kuan Chen, An-Min Liu, and Wang-Qing Cai. "Therapy and Prognosis of Intracranial Invasive Olfactory Neuroblastoma." Otolaryngology–Head and Neck Surgery 145, no. 6 (2011): 951–55. http://dx.doi.org/10.1177/0194599811416752.

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Objective. There is currently no consensus on a standardized treatment strategy for olfactory neuroblastoma (ONB), especially for intracranial invasion. This purpose of this study is to explore the appropriate treatment modality and prognostic factors of intracranial invasive ONB. Study Design. Case series with chart review. Setting. The study was conducted at the Sun Yat-sen Memorial Hospital and the Cancer Center of Sun Yat-sen University, China. Subjects and Methods. Twenty-five cases of intracranial invasive ONB were collected and investigated using a retrospective review analysis from pat

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Zhong, Jiaojiao, Yunan He, Jianchi Ma, Siyao Lu, Yushi Wu, and Junmin Zhang. "Development and validation of a nomogram risk prediction model for malignancy in dermatomyositis patients: a retrospective study." PeerJ 9 (December 9, 2021): e12626. http://dx.doi.org/10.7717/peerj.12626.

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Background Dermatomyositis accompanied with malignancy is a common poor prognostic factor of dermatomyositis. Thus, the early prediction of the risk of malignancy in patients with dermatomyositis can significantly improve the prognosis of patients. However, the identification of antibodies related to malignancy in dermatomyositis patients has not been widely implemented in clinical practice. Herein, we established a predictive nomogram model for the diagnosis of dermatomyositis associated with malignancy. Methods We retrospectively analyzed 240 cases of dermatomyositis patients admitted to Sun

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Qin, Zeman, Haotian Cao, Yongqian Xu, et al. "Tooth Loss after Jaw Curettage Surgery: Associated Factors and Potential Benefit of Splint Application." Disease Markers 2022 (January 28, 2022): 1–9. http://dx.doi.org/10.1155/2022/7750229.

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Background. This retrospective study is aimed at (I) assessment of tooth loss and related parameters after jaw curettage of benign lesions and (II) assessment of the outcome of jaw curettage supported by splint insertion after at least six months of follow-up. Material and Methods. For (I), patients who had jaw curettage surgery in the Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (Guangzhou, China) from July 2015 to June 2019 were included. For part (II), consecutive patients who came to the department from July to December 2019 that were

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Yang, Xinguang, Xiongjun He, Dong Pan, et al. "Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial." BMJ Open 14, no. 11 (2024): e091059. http://dx.doi.org/10.1136/bmjopen-2024-091059.

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IntroductionSuccessful reperfusion does not always lead to good neurological outcomes and impaired microcirculation can be one of the underlying causes. Intra-arterial alteplase after mechanical thrombectomy (MT) may improve microcirculation contributing to neurological recovery, but prospective randomised studies are still needed to validate its efficacy and safety. We aim to assess the efficacy and safety of intra-arterial alteplase after MT for acute ischaemic stroke (AIS) with large-vessel occlusion (LVO).Methods and analysisTheIntra-arterial Alteplase for Acute Ischaemic Stroke After Mech

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Zhou, Shengning, Yequan Xie, Yingying Zhu, et al. "Comparing the antireflux effect of laparoscopic proximal gastrectomy with double-flap technique reconstruction versus laparoscopic total gastrectomy with Roux-en-Y reconstruction for proximal early gastric cancer: study protocol for a multicentre, prospective, open-label, randomised controlled trial." BMJ Open 14, no. 7 (2024): e079940. http://dx.doi.org/10.1136/bmjopen-2023-079940.

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IntroductionLaparoscopic proximal gastrectomy with double flap technique (LPG-DFT) reconstruction has been used for proximal early gastric cancer in recent years. However, its feasibility and safety remain uncertain, as only a few retrospective studies have contained postoperative complications and long-term survival data. LPG-DFT for proximal early gastric cancer is still in the early stages of research. Large-scale, prospective randomised controlled trials (RCTs) are necessary to assess the value of LPG-DFT for proximal early gastric cancer.Methods and analysisThis study is a multicentre, pr

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Liu, Jing, Yuting Tan, Zhuofei Bi, et al. "RecurIndex-Guided postoperative radiotherapy with or without Avoidance of Irradiation of regional Nodes in 1–3 node-positive breast cancer (RIGAIN): a study protocol for a multicentre, open-label, randomised controlled prospective, phase III trial." BMJ Open 14, no. 7 (2024): e078049. http://dx.doi.org/10.1136/bmjopen-2023-078049.

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IntroductionPostoperative radiotherapy in patients with breast cancer with one to three lymph node metastases, particularly within the pT1–2N1M0 cohort with a low clinical risk of local–regional recurrence (LRR), has incited a discourse surrounding personalised treatment strategies. Multigene testing for Recurrence Index (RecurIndex) model capably differentiates patients based on their level of LRR risk. This research aims to validate whether a more aggressive treatment approach can enhance clinical outcomes in N1 patients who possess a clinically low risk of LRR, yet a high RecurIndex-determi

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Qin, Tao, Hao Yu, Bo Wang, et al. "PD-L1 and neutrophil to lymphocyte ratio (NLR) as predictive panel of prognosis in bladder cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): e17040-e17040. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e17040.

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e17040 Background: PD-1/PD-L1 blockade significantly improved survival for bladder cancer. PD-L1 expression might not be an ideal marker for patient selection in isolation. Several studies demonstrated that alternative markers such as NLR, a biomarker of systemic inflammation response to therapy, correlated with outcomes in a variety of cancers including bladder cancer, might be a predictor for patient selection and the response to immunotherapy. However, no reporters have been made combination of NLR and PD-L1 in predicting prognosis in bladder cancer. Methods: Suitable tissue of 100 FFPE blo

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Long, Miaoyun, Dingyuan Luo, Feiyu Diao, et al. "A Carbon Nanoparticle Lymphatic Tracer Protected Parathyroid Glands During Radical Thyroidectomy for Papillary Thyroid Non-Microcarcinoma." Surgical Innovation 24, no. 1 (2016): 29–34. http://dx.doi.org/10.1177/1553350616668088.

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The study assessed the role of an activated carbon nanoparticle lymphatic tracer in reducing unintentional damage to the parathyroid glands during thyroidectomy for papillary thyroid non-microcarcinoma diagnosed intraoperatively by cryosections. A total of 103 patients with papillary thyroid non-microcarcinomas diagnosed by intraoperative cryosection were randomly assigned to receive routine radical thyroidectomy or radical thyroidectomy following administration of activated carbon nanoparticle lymphatic tracer to the contralateral thyroid, at the department of Thyroid Surgery, Sun Yat-sen Mem

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Shang, Changzhen, Jinyi Zhong, Xuan Luo, et al. "An observational study of donafenib as adjuvant therapy to prevent hepatocellular carcinoma recurrence after curative surgery." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16227-e16227. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16227.

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e16227 Background: The five-year recurrence rate of hepatocellular carcinoma (HCC) after hepatic resection is as high as 70% and remains a major clinical challenge. Many investigators have suggested adjuvant therapy to prevent HCC recurrence, and several promising outcomes have been reported. Donafenib has been approved as a standard treatment for patients with unresectable HCC in China. Here, we describe our preliminary results regarding the efficacy and safety of donafenib as an adjuvant therapy for patients with HCC after hepatectomy. Methods: This was an observational study of patients wit

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Fang, Hang, Daozhang Cai, Lisi Huang, and Qiuying He. "PLASMA FIBRINOGEN IS A PROMISING FIRST-LINE SCREENING BIOMARKER FOR THE DIAGNOSIS OF PERIPROSTHETIC JOINT INFECTION AND TIMING OF REIMPLANTATION: A MULTICENTRE RETROSPECTIVE STUDY." Orthopaedic Proceedings 105-B, SUPP_17 (2023): 69. http://dx.doi.org/10.1302/1358-992x.2023.17.069.

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AimThe diagnosis of periprosthetic joint infection (PJI) remains a clinical dilemma, since presentations of PJI usually greatly overlap with aseptic failure (AF). The aim of this study is to evaluate the values of plasma fibrinogen, individually or in combination with CRP, ESR and WBC, for distinguishing PJI from AF.MethodWe retrospectively enrolled 357 cases who underwent revision hip or knee arthroplasties in the Third Affiliated Hospital of Southern Medical University, Sun Yat-sen Memorial Hospital and the First Affiliated Hospital of Sun Yat-sen University from January 2013 to December 202

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Xie, Xiaoying, Yunwen Bao, Lijia Ni, et al. "Bacterial Profile and Antibiotic Resistance in Patients with Diabetic Foot Ulcer in Guangzhou, Southern China: Focus on the Differences among Different Wagner’s Grades, IDSA/IWGDF Grades, and Ulcer Types." International Journal of Endocrinology 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8694903.

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Objective. To understand the bacterial profile and antibiotic resistance patterns in diabetic foot infection (DFI) in different Wagner’s grades, IDSA/IWGDF grades, and different ulcer types in Guangzhou, in order to provide more detailed suggestion to the clinician about the empirical antibiotic choice. Methods. 207 bacteria were collected from 117 DFIs in Sun Yat-sen Memorial Hospital from Jan.1, 2010, to Dec.31, 2015. The clinical data and microbial information were analyzed. Results. The proportion of Gram-negative bacteria (GNB) was higher than Gram-positive bacteria (GPB) (54.1% versus 45

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Zhang, Jiaqi, Jun Ge, Chen Chen, et al. "The Effectiveness of Using CO2 Fractional Laser and Mebo Burn Ointment Together in Treating Scars on the Face after Surgery." Plastic and Reconstructive Surgery - Global Open 11, no. 9 (2023): e5254. http://dx.doi.org/10.1097/gox.0000000000005254.

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Background: This study aimed to investigate the efficacy and safety of CO2 fractional laser combined with Mebo burn ointment in treating facial postoperative scars. Methods: Sixty patients with facial postoperative scars in the department of plastic surgery of Sun Yat-sen Memorial Hospital from January 2020 to June 2022 were divided into a control group (30 cases) and a study group (30 cases). Both groups received CO2 fractional laser treatment, but the study group also received Mebo burn ointment application. Results: The study found that both methods resulted in a significant decrease in Saw

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Liu, Jieqiong, Jianli Zhao, Zhixian Sun, et al. "Abstract P5-02-35: Radiomic biomarkers to predict the efficacy of anti-PD-1 immunotherapy-based combinational treatment in advanced breast cancer: a multi-center study." Cancer Research 83, no. 5_Supplement (2023): P5–02–35—P5–02–35. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-02-35.

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Abstract Introduction: Immunotherapy, especially immune checkpoint inhibitors, is regarded as one of the major breakthroughs in breast cancer treatment. However, it is an important challenge to accurately locate the patients who benefit from immunotherapy, because there is still a lack of universal and robust predictors of the efficacy of immunotherapy. Radiomics can extract quantitative imaging features in a highthroughput manner and assess tumor microenvironment and heterogeneity. This study investigated the correlation between deep learning radiomic biomarkers, including its predictive valu

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Shang, Changzhen, Xuan Luo, Jinyi Zhong, et al. "Real-world efficacy and safety of donafenib-based therapies in patients with unresectable hepatocellular carcinoma: A retrospective study." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16169-e16169. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16169.

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e16169 Background: According to the results of phase III ZGDH3 study, donafenib has significantly improved overall survival (OS) versus sorafenib in first-line treatment for patients with unresectable hepatocellular carcinoma (uHCC). The present study aimed to evaluate the efficacy and safety of donafenib-based therapies in patients with uHCC regardless of first- or later-line systemic therapy. Methods: This single-center retrospective study involved 30 patients with histopathologically/cytologically or clinically confirmed uHCC at Sun Yat-sen Memorial Hospital, Sun Yat-sen University between

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Fan, Shu-Xian, Peng Zeng, Zi-Jing Li, et al. "The Clinical Features of Graves’ Orbitopathy with Elevated Intraocular Pressure." Journal of Ophthalmology 2021 (January 25, 2021): 1–5. http://dx.doi.org/10.1155/2021/9879503.

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Background. To investigate the clinical characteristics of Graves’ orbitopathy (GO) with elevated intraocular pressure (IOP) using the European Group of Graves’ Orbitopathy (EUGOGO) system. Methods. In this retrospective study, the clinical data of GO patients with elevated IOP (≥21 mmHg) were collected in Sun Yat-sen Memorial Hospital from January 2010 to June 2016. The demographic characteristics, clinical history of thyroid disease and GO, and ocular examination data were evaluated, and the activity and severity of GO were classified. Results. Data were collected from 58 eyes of 39 patients

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Wang, Yuhan, Haijian Zhou, Guanglei Zhong, Zhaojie Fu, Yu Peng, and Tingting Yao. "Development and Validation of a Nomogram to Predict the Probability of Venous Thromboembolism in Patients with Epithelial Ovarian Cancer." Clinical and Applied Thrombosis/Hemostasis 28 (January 2022): 107602962210955. http://dx.doi.org/10.1177/10760296221095558.

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Objective To identify predictive factors and develop a nomogram to predict the probability of venous thromboembolism for epithelial ovarian cancer patients. Methods: Our study cohort was composed of 208 EOC patients who had received initial treatment in Sun Yat-sen Memorial Hospital from January 2016 to March 2020. Clinicopathological variables predictive of VTE were identified using univariate logistic analysis. A multivariate logistic regression model was used to select the predictive factors used for nomogram. The accuracy of nomogram was evaluated by the Concordance index (C-index), the ar

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Ghimire, Hridaya Bibhu, Jian Guo Li, and Zhuan Sun Yong-Xun. "Effect on Lung Structure, Inflammatory and Nutritional Status of COPD Patients with Fibrotic and Proliferative Tuberculosis Changes in Chest Imaging." Journal of Nobel Medical College 3, no. 1 (2014): 40–44. http://dx.doi.org/10.3126/jonmc.v3i1.10053.

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Background and objectives Tuberculosis and COPD are common diseases in developing countries, sharing risk factors like smoking and low socio-economic status but little is known about the specific relationship between tuberculosis and COPD. Methods Retrospective analysis was done. All COPD patients with either fibrotic and proliferative tubercular changes in chest imaging or none of the features of tuberculosis (in chest imaging, sputum test, skin test or history) admitted in Sun Yat- Sen Memorial Hospital, China from the year 2007 to 2010 were taken for the study. Clinical features along with

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Huang, Junbin, Lifeng Huang, Su Liu, et al. "Clinical Outcome of Pediatric Acquired Aplastic Anemia Underwent Immunosuppressive Therapy and Transplantation: A 13-Year Experience in Two Tertiary Care Centers , Southern China." Blood 134, Supplement_1 (2019): 5022. http://dx.doi.org/10.1182/blood-2019-128617.

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Objective To evaluate efficacy, complications and contributing factors for response of immunosuppressive therapy(IST) and allogenic hematopoietic stem cell transplantation(allo-HSCT) in children with acquired aplastic anemia; to explore optimal therapy for different clinical types of aplastic anemia. Methods 230 children diagnosed with aplastic anemia accepted immunosuppressive therapy from January 1, 2006 to July 15, 2019 in Department of pediatrics, Sun Yat-sen memorial hospital and Department of pediatrics, The seventh affiliated hospital, Sun Yat-sen University, the response rate for 3, 6,

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Huang, Xinyi, Liming Shu, Su Xiao, et al. "Association between Low Ambient Temperature and the Severity of Acute Ischemic Stroke." Journal of Clinical and Nursing Research 8, no. 5 (2024): 83–94. http://dx.doi.org/10.26689/jcnr.v8i5.7284.

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Objective: To explore the relationships among ambient temperature, ischemic stroke severity, and blood pressure. Methods: Meteorological data (2005–2015) were collected from the Guangzhou Meteorological Data Service. Ischemic stroke patients from the Department of Neurology of the First Affiliated Hospital, Sun Yat-sen University were retrospectively evaluated, each winter from 2005 to 2015. Patient demographics, baseline measurements, and National Institute of Health Stroke Scale (NIHSS) score were evaluated. Results: Three hundred sixty-two patients were included. The median latency from sym

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Huang, Xiaolong, Xiaoni Zhang, Xicheng Wang, et al. "A nomogram to predict symptomatic epilepsy in patients with radiation-induced brain necrosis." Neurology 95, no. 10 (2020): e1392-e1403. http://dx.doi.org/10.1212/wnl.0000000000010190.

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ObjectiveTo develop and validate a nomogram to predict epilepsy in patients with radiation-induced brain necrosis (RN).MethodsThe nomogram was based on a retrospective analysis of 302 patients who were diagnosed with symptomatic RN from January 2005 to January 2016 in Sun Yat-sen Memorial Hospital using the Cox proportional hazards model. Discrimination of the nomogram was assessed by the concordance index (C index) and the calibration curve. The results were internally validated using bootstrap resampling and externally validated using 128 patients with RN from 2 additional hospitals.ResultsA

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Zeng, Peng, Shu-xian Fan, Zi-jing Li, et al. "Evaluation of the Graves’ Orbitopathy-Specific Quality of Life Questionnaire in the Mainland Chinese Population." Journal of Ophthalmology 2019 (March 18, 2019): 1–5. http://dx.doi.org/10.1155/2019/7602419.

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Purpose. To study the clinical significance of the Graves’ orbitopathy-specific quality of life (GO-QOL) questionnaire in mainland Chinese patients. Methods. A cross-sectional study was performed at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from April 2017 to April 2018. Eighty-eight consecutive Graves’ orbitopathy (GO) patients completed the two subscales of the GO-QOL questionnaire: visual functioning and appearance. The disease severity of GO was measured by the European Group on Graves’ Orbitopathy (EUGOGO) classification, and clinical activity was evaluated by the

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Liao, Shumei, Diaozhu Lin, Qiling Feng, et al. "Lipid Parameters and the Development of Chronic Kidney Disease: A Prospective Cohort Study in Middle-Aged and Elderly Chinese Individuals." Nutrients 15, no. 1 (2022): 112. http://dx.doi.org/10.3390/nu15010112.

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Epidemiological evidence suggests that lipid parameters are related to the progression of chronic kidney disease (CKD). Nevertheless, prospective studies that comprehensively assess the effect of routinely available lipid measures on the development of CKD are lacking. The aim of this study was to longitudinally assess the influence of lipid metabolism indicators on the presence of CKD in a large community-based population. We conducted a prospective cohort study at Sun Yat-sen Memorial Hospital, China, with 5345 patients of 40 years or older. Cox regression models were conducted, and hazard r

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Wang, Ningning, Yufeng Zhang, and Bin Liu. "Demographic and Clinical Features of Endometrial Polyps in Patients with Endometriosis." BioMed Research International 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/1460793.

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Aims. To compare the clinical features of endometrial polyps (EPs) between patients with endometriosis (EM) (EM group) and without EM (non-EM group).Methods and Results. Seventy-six cases in the EM group and 133 cases in the non-EM group underwent laparotomy or hysteroscopy and laparoscopy; later, it was confirmed that the results by pathology from July 2002 to April 2008 in the Department of Gynecology and Obstetrics at the First Affiliated Hospital of Sun Yat-sen University. The recurrence of EPs was followed up after the surgery until 2013. The following parameters were assessed: age, gravi

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Li, Honghong, Yong He, Xiaohuang Zhuo, et al. "Establishment and Validation of a Predictive Model for Radiation-Associated Aspiration Pneumonia in Patients with Radiation-Induced Dysphagia after Nasopharyngeal Carcinoma." Behavioural Neurology 2022 (August 19, 2022): 1–10. http://dx.doi.org/10.1155/2022/6307804.

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Introduction. Radiotherapy for patients with head and neck cancers raises their risk of aspiration pneumonia-related death. We aimed to develop and validate a model to predict radiation-associated aspiration pneumonia (RAP) among patients with dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC). Materials and Methods. A total of 453 dysphagic patients with NPC were retrospectively recruited from Sun Yat-Sen Memorial Hospital from January 2012 to January 2018. Patients were randomly divided into training cohort ( n = 302 ) and internal validation cohort ( n = 151 ) at a ratio of 2 :

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Hou, Jingyi, Qingyue Li, Menglei Yu, et al. "Validation of a Mobile Version of the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form: An Observational Randomized Crossover Trial." JMIR mHealth and uHealth 8, no. 7 (2020): e16758. http://dx.doi.org/10.2196/16758.

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Background The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES) questionnaire is an effective tool for evaluating shoulder joint function. The development and usage of a mobile version of the ASES questionnaire has the potential to save time, money, and effort. Objective The aim of this study is to assess the equivalence between the paper and mobile versions of the ASES questionnaire and their acceptability among patients. Methods The paper and mobile versions of the ASES questionnaire were used to evaluate the shoulder joint function of 50 patients with should

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Liang, Riying, Man Luo, Xinhua Yang, Baoming Luo, and Rongbin Liu. "Mutational Profiling Detection in FNAC Samples of Different Types of Thyroid Neoplasms Using Targeted NGS." Cancers 17, no. 15 (2025): 2429. https://doi.org/10.3390/cancers17152429.

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Background: Thyroid neoplasms exhibit a diverse molecular landscape, and the 2022 WHO classification emphasizes the critical role of molecular profiling in thyroid cancer management; however, comprehensive mutational data from fine-needle aspiration cytology (FNAC) samples using targeted next-generation sequencing (NGS) are still limited, necessitating further investigation to guide clinical practice. Purpose: To characterize the mutational landscape of thyroid neoplasms using targeted NGS of FNAC samples and to assess the clinical implications of molecular profiling. Materials and Methods: Th

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Sheng, Hui, Yagui Qiu, Xi Xia, et al. "Sexual Effect of Platelet-to-Lymphocyte Ratio in Predicting Cardiovascular Mortality of Peritoneal Dialysis Patients." Mediators of Inflammation 2022 (January 4, 2022): 1–9. http://dx.doi.org/10.1155/2022/8760615.

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Background. The study is aimed at exploring the relationship of platelet-to-lymphocyte (PLR), all-cause, and cardiovascular disease (CVD) mortality in peritoneal dialysis (PD) patients based on gender. Methods. A total of 1438 PD patients from January 1,2007 to December 31, 2014 in PD center at The First Affiliated Hospital, Sun Yat-sen University, were included. Patients were followed up until December 31, 2019. The endpoint was all-cause mortality and CVD mortality. Cox proportional hazards regression models were used to evaluate the association of PLR with all-cause and CVD mortality to cal

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Ren, Chao, and Rui-hua Xu. "Prognostic effects of 25-hydroxyvitamin d levels in gastric cancer." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14653-e14653. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14653.

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e14653 Background: Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown. Methods: 197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the progno

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He, Zhen, Xiaowen Lan, Yuting Tan, et al. "Identification of Risk Factors Associated with Axillary Lymph Node Metastasis for Sentinel Lymph Node-Positive Breast Cancer Patients." Journal of Oncology 2020 (December 29, 2020): 1–9. http://dx.doi.org/10.1155/2020/8884337.

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Objective. This study aimed to identify clinicopathological factors related to the extent of axillary lymph node (ALN) involvement in early-stage BC patients with positive sentinel lymph nodes (SLNs). Methods. This was a retrospective analysis of 566 patients in cT1-2N0M0 with 1-2 positive SLNs that underwent axillary lymph node dissection (ALND) at Sun Yat-Sen Memorial Hospital. The clinical and pathologic data from these patients were analyzed. Results. Of these 566 patients, 235 (41.5%) exhibited NSLN metastases. Multivariate analysis revealed that the number of positive SLNs (odds ratio (O

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Zhou, Xun. "The Troublesome Legacy of Commissioner Lin: The Opium Trade and Opium Suppression in Fujian Province, 1820s to 1920s. By Joyce A. Madancy. [Harvard and London: Harvard East Asia Monograph, 2003. 430 pp. $50.00; £32.95. ISBN 0-674-01215-1.]." China Quarterly 182 (June 2005): 449–50. http://dx.doi.org/10.1017/s0305741005320261.

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Visiting New York's Chinatown, it is surprising to find there a memorial statue of the legendary anti-opium hero, Lin Zexu, instead of the more usual statue of the father of modern China, Sun Yat-sen. Perhaps Lin deserves his place in New York's Chinatown: it is generally believed the history of Chinese migration into the New World was a chapter of humiliation, resulting from the evil opium and the opium trade. Until very recently, the conventional wisdom has been that it was the opium trade that ended the house of Qing, and that opium had turned China into a nation of hopeless addicts, smokin

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Zhang, Li-Hua, Jing-Yan Li, Qi Tian, et al. "Follow-up and evaluation of the pregnancy outcome in women of reproductive age with Graves’ disease after 131Iodine treatment." Journal of Radiation Research 57, no. 6 (2016): 702–8. http://dx.doi.org/10.1093/jrr/rrw049.

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Abstract The aims of the present study were to analyze the outcomes of pregnancy, after 131I treatment, in patients of reproductive age with Graves’ hyperthyroidism and to investigate the effects, if any, of the 131I treatment on the mothers and newborns. From 2009 to 2014, 257 pregnant female patients with Graves’ hyperthyroidism in the outpatients at the Department of Nuclear Medicine and 166 healthy pregnant women from the Department of Obstetrics at Sun Yat-Sen Memorial Hospital were included in our study. They were divided into a 131I therapy group (n = 130) and an anti-thyroid drug (ATD)

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Zeng, Peng, Xiao-wen Deng, Peng Tian, et al. "The Outcomes of Balanced Orbital Decompression for Dysthyroid Optic Neuropathy: Focusing on Choroiretinal Folds with and without Optic Disc Edema." Disease Markers 2023 (February 21, 2023): 1–9. http://dx.doi.org/10.1155/2023/9503821.

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Purpose. To assess the outcomes of balanced orbital decompression for chorioretinal folds (CRFs) with and without optic disc edema (ODE) in dysthyroid optic neuropathy (DON). Method. A retrospective, interventional study was performed at Sun Yat-sen Memorial Hospital from April 2018 to November 2021. We collected the medical records of 13 patients (24 eyes) with DON and CRFs. Then, we divided them into the ODE group (15 eyes, 62.5%) and the non-ODE group (NODE group, 9 eyes, 37.5%). The valid ophthalmic examination parameters of 8 eyes in each group after balanced orbital decompression were co

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Qi, Jing-Wan, Bing Huang, Shuang Wang, et al. "Association Between Plasma Vitamin D2 and Type 2 Diabetes Mellitus." Frontiers in Endocrinology 13 (June 1, 2022). http://dx.doi.org/10.3389/fendo.2022.897316.

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ObjectiveTo investigate the relationship between plasma vitamin D2(VD2) and type 2 diabetes(T2DM).MethodData from electronic medical records of 797 inpatients treated at Sun Yat Sen Memorial Hospital, Sun Yat-sen University between June 24, 2019 and December 24, 2020 were collected, and a total of 596 patients were enrolled after screening based on inclusion and exclusion criteria. Patients were divided into diabetic and non-diabetic groups according to whether they had T2DM. The Wilcoxon rank sum test was finally selected for the analysis of differences between groups according to the distrib

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