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Journal articles on the topic 'Super Disintegrant'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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2

Vishwasrao, S. S., and A. Jadhav. "STUDIES ON FORMULATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS USING MUSA ACUMINATA AS A NATURAL DISINTEGRANT FOR PAEDIATRIC USE." INDIAN DRUGS 53, no. 12 (2016): 55–58. http://dx.doi.org/10.53879/id.53.12.10628.

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The aim of the present study was to optimize an orally disintegrating tablet of ibuprofen (~100mg) using Musa acuminata (dehydrated banana powder) as a natural super disintegrant. In this work, dehydrated banana powder was used as pharmaceutical excipient because of natural origin and high nutrition properties for paediatric formulation. These tablets were prepared by direct compression technique and compared with formulations made by using synthetic super disintegrants Croscarmellose sodium, micro crystalline cellulose and Cross povidone. FTIR studies of formulations have shown no interaction

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3

Azubuike, Chukwuemeka P., Uloma N. Ubani-Ukoma, Abiola R. Afolabi, and Ibilola M. Cardoso-Daodu. "Evaluation of super-disintegrant potential of acid-modified starch derived from Borassus aethiopum (Aracaceae) shoot in paracetamol tablet formulations." Tropical Journal of Pharmaceutical Research 19, no. 3 (2020): 459–65. http://dx.doi.org/10.4314/tjpr.v19i3.1.

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Purpose: To evaluate the super-disintegrant potentials of acid modified Borassus aethiopum starch (AMS) in comparison with native starch (NS) and commercial disintegrant sodium starch glycolate (SSG). Methods: Compatibility of AMS with paracetamol powder was evaluated using Fourier transform infrared (FTIR) spectrophotometry. Seven batches of paracetamol granules and tablets were prepared by wet granulation. AMS and NS were employed as disintegrants at concentrations of 2.43, 4.86 and 9.72 %w/w, respectively while 4.86 %w/w SSG was used as standard disintegrant. All the batches of the gr

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Raziya, Begum Sheikh. "Development and Assessment of Naproxen Mouth Dissolving Tablets." medtigo Journal of Pharmacology 1, no. 1 (2024): e13377773. https://doi.org/10.5281/zenodo.13377773.

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The market demand for orally disintegrating tablets has experienced a significant surge over the past decade. This intervention is particularly beneficial for geriatric and pediatric patients who experience challenges in ingesting traditional tablets and capsules. The utilization of a fast dissolving or fast disintegrating dosage form confers advantages to patients in this context. Fast dissolvable or fast disintegrating dosage forms are designed to rapidly disintegrate upon exposure to saliva, resulting in accelerated drug release within the oral cavity. The administration of fast-disintegrat

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5

Kute, S. Shivaji*1 Sonwane Sonali S*2 Jadhav Vaibhav A2. "Super Disintegrants: An Overview." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 77–89. https://doi.org/10.5281/zenodo.10464297.

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Disintegrants play a crucial role as excipients in solid oral formulations. In immediate release and oral dispersible tablet formulations, super disintegrants like croscarmellose sodium, sodium starch glycolate, crospovidone, and polacrilin potassium are added in small quantities to counteract the effects of compression and binder after administration. The hygroscopic nature of these super disintegrants facilitates the penetration of water into the tablet matrix, while their cross-linkage reduces solubility in water. This article provides an overview of various factors that can influence the f

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6

Gurram, Syam Sundar, Nagaveni P, and Sreevalli Arigela. "Formulation and evaluation of nifedipine fast dissolving tablets." Future Journal of Pharmaceuticals and Health Sciences 4, no. 2 (2024): 32–38. http://dx.doi.org/10.26452/fjphs.v4i2.599.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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7

Gurram, Syam Sundar. "Formulation and evaluation of nifedipine fast dissolving tablets." Formulation and evaluation of nifedipine fast dissolving tablets 4, no. 2 (2025): 32–38. https://doi.org/10.5281/zenodo.14651206.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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8

Sahoo, Suvendu, and Samyuktha Metta. "An Exploration of The Potential of Natural Super Disintegrating Agents in Pharmaceutical Formulations: A Review." Journal of Pharmacological and Pharmaceutical Research 1, no. 1 (2024): 21. http://dx.doi.org/10.5455/jppr.20240107023841.

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This review delves into the use of natural super disintegrating agents in pharmaceutical drug formulations. Disintegrants are incorporated into these formulations to aid in breaking down tablets and capsules, promoting rapid dissolution by facilitating their dispersion into smaller particles. Super disintegrants, distinguished by their notable swelling capacity, play a pivotal role in expediting drug disintegration within the gastrointestinal tract. The selection of an appropriate super disintegrant hinges on several factors, including chemical compatibility, swelling potential, disintegration

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9

Puri, Abhijeet Vishnu, Prakash D. Khandagale, Ankita U. Tiwari, Rekhadevi H. Chaudhary, and Sonam B. Kartan. "Synthesis and Physicochemical Characterization of Banana Starch Tartrate and its Application as Disintegrant in Telmisartan Tablets." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 65–72. http://dx.doi.org/10.22270/jddt.v10i3.4089.

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The present investigation was aimed to isolate banana starch (BS), synthesis of banana starch tartrate (BST), characterization, and application as a novel disintegrant in telmisartan tablets. Starch tartrate was synthesized by the esterification process by the treatment of tartaric acid on the backbone of the BS. Synthesized BST was found to be fine, slightly free-flowing and crystalline powder. The synthesized BST was subjected to Scanning Electron Microscopy (SEM) and micrometric evaluation. Flow properties of BS and BST were determined as an angle of repose, bulk density, tapped density, Ca

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10

Nabila Nabila and Sry Ulina Karo-Karo. "Exploring natural disintegrant as alternative excipients sources for tablet formulation: A systematic review." International Journal of Science and Research Archive 13, no. 2 (2024): 3296–305. https://doi.org/10.30574/ijsra.2024.13.2.2530.

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Optimizing the disintegration and dissolution of orally administered tablets is crucial for releasing active pharmaceutical ingredients (APIs) for absorption. This review explores disintegrant research, focusing on natural super disintegrants and co-processed excipients that collected from 2010-2024. Natural disintegrants such as Silicified Oryza Sativa Starch, Plantago ovata mucilage, and gum karaya show promising results. Silicified Oryza Sativa Starch enhances paracetamol tablet disintegration, while Plantago ovata mucilage outperforms Crosspovidone. Gum karaya offers a cost-effective, bioc

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11

Rupali, Patel, Upadhyay Nikita, Sonartiya Sunita, Jain Sourabh, and Dubey P.K. "Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 42–66. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.004.

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Direct compression method can be considered as an important method for the formulation of fast dissolving tablets of Domperidone compare to wet granulation method. The rank order for the best 3 formulations is F2>F1. Formulation F2 having DCP as the super disintegrant is the best formulation of all. Higher the concentration of the lubricating agent (Magnesium Stearate or Talc), higher will be the disintegration time. Formulation having the better Super disintegrants (Ac-Di-Sol) will have better in vitro disintegration time and dissolution along with lesser friability and weight variation. T

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12

Amruta, Pol*1 Rachana Sarawade2. "Development And Evaluation Of Sublingual Tablets Of Levodopa." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 125–40. https://doi.org/10.5281/zenodo.11109715.

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The objective of the development of this formulation was to develop a suitable drug delivery system that would bypass the hepatic metabolism and increase the bioavailability of Levodopa. Even though Levodopa exhibits low oral bioavailability it is the widely used drug for Parkinson’s disease treatment. By preparing the sublingual tablets that dissolve and disintegrate in the oral cavity, this method may overcome the limitations of low oral bioavailability and poor brain uptake of levodopa. Levodopa Sublingual tablets were prepared by direct compression method using different types of sup

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13

Gaikwad, Bhavna B., Bhushan R. Rane, and Ashish S. Jain. "Formulation and Evaluation of Orodispersible Tablet of Sulindac." European Journal of Pharmaceutical Research 2, no. 3 (2022): 11–19. http://dx.doi.org/10.24018/ejpharma.2022.2.3.41.

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Oral administration of dosage form is the most recommended mode of administration, because of its self-medication, accurate dose of the drug, and ease of administration. However, trouble swallowing in geriatric patients is one major negative of this route, which can mentally disrupt patients. The goal of this study was to use the direct compression method to make orodispersible tablets of sulindac utilizing various doses of super disintegrant agents such as Sodium starch glycolate Crospovidone and Croscarmellose sodium. Three distinct super disintegrants were used to create nine formulations w

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14

Ankit, A., G. B. Kiran Kumar, and B. K. Madhu. "Formulation and evaluation of orodispersible tablets of dimenhydrinate by using co-processed superdisintegrants." Kathmandu University Journal of Science, Engineering and Technology 12, no. 1 (2018): 23–33. http://dx.doi.org/10.3126/kuset.v12i1.21562.

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The main objective of this study was to formulate orodispersible tablets of Dimenhydrinate for quick relief of emesis. Orodispersible tablets were prepared by direct compression method using co-processed super-disintegrants. Co-processed super-disintegrants are the mixture of crospovidone and guar gum in different ratios. The powder mixtures and tablets were subjected to various pre-compression and post-compression evaluations. IR spectroscopy showed no interaction between drug and other excipients. Angle of repose and Carr’s index was found in the range of 23.89°-28.27° and 23.29-15.48 respec

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15

Purkayastha, Hrishav Das, and Bipul Nath. "FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 92. http://dx.doi.org/10.22159/20966.

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Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magne

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16

Zhao, Na, and Larry L. Augsburger. "The Influence of Granulation on Super Disintegrant Performance." Pharmaceutical Development and Technology 11, no. 1 (2006): 47–53. http://dx.doi.org/10.1080/10837450500463828.

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17

Karanam, Fathima Nilesh Kadiyala Arun Kumar2 B.T.N.Vamsi Krishna. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACECLOFENAC BY USING ISPAGHULA HUSK POWDER AS NATURAL SUPER DISINTEGRANT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1793–801. https://doi.org/10.5281/zenodo.1210762.

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Fast disintegrating tablets (FDTs) are meant for administration to the patients who cannot swallow, such as elderly, stroke victims, bedridden patients, patients affected by renal failure, and the patients who refuse to swallow, such as pediatric, geriatric, and psychiatric patients. The present study is aimed to prepare orally disintegrating tablet of a model drug – Aceclofenac, using Ispaghula powder as natural super disintegrant, to conduct incompatibility studies by using Fourier-transform infrared spectroscopy (FTIR), to evaluate the prepared tablets for weight variation, friability

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18

Iswariya, V. T., Nambaaru Sailaja, CH Vamsi Krishna, and G. S. Annammadevi. "Natural Super-Disintegrant Agents Used in Various Oral Solid Dosage Forms." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 110–13. http://dx.doi.org/10.22270/jddt.v11i1.4681.

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Super-disintegrating agents are one of the ingredients used in pharmaceutical solid dosage forms. These substances play a vital role in formulation design. Natural super-disintegrants have gained more popularity due to their oral bioavailability. It disintegrates the tablets into smaller particles to enhance the dissolution rate. Fast dissolving, chewable tablets, and other orally administered dosage forms consist of super-disintegrating agents which shows rapid and quick action. Natural super disintegrating agents in pharmaceutical dosage forms are very effective due to their ecofriendly natu

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19

Siji, C. Ann Rose Augusthy and Vipin K.V. "FORMULATION AND EVALUATION OF CARVEDILOL SUBLINGUAL TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1043–50. https://doi.org/10.5281/zenodo.1185156.

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Carvedilol is an oral antihypertensive agent. Due to its poor water solubility it posses problems of variable bioavailability and bioequivalence. In the present work an attempt was done to develop sublingual tablets of carvedilol using different superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate in different ratios. As carvedilol is a poor soluble drug the solubility was enhanced by solid dispersion method. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wett

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20

Ilango, Kumbakonam Balachandran, Senguttuvan Gowthaman, Kumbakonam Ilango Seramaan, et al. "Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient." Polymers 14, no. 1 (2022): 215. http://dx.doi.org/10.3390/polym14010215.

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Natural eco-friendly materials are recently employed in products to replace synthetic materials due to their superior benefits in preserving the environment. The herb Coccinia grandis is widely distributed in continents like Asia and Africa and used traditionally to treat fever, leprosy, asthma, jaundice, and bronchitis. Mucilage of Coccinia grandis was accordingly extracted, isolated by a maceration technique, and precipitated. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical prop

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21

H. Tizkam, Hussam, Alaa A. Abdul Rassol, and Ahmed A. Hussain. "Preparation of a New Dosage Form of Metoclopramide Hydrochloride as Orodispersible Tablet." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, no. 1 (2017): 38–48. http://dx.doi.org/10.31351/vol18iss1pp38-48.

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Metoclopramide HCl (MTB) is a potent antiemetic drug used for the treatment of nausea and vomiting. Many trials were made to prepare a satisfactory MTB orodispersible tablet using direct compression method.Various super disintegrants were used in this study which are croscarmellose sodium (CCS), sodium starch glycolate (SSG) and crospovidone (CP). The latter was the best in terms of showing the fastest disintegration time in the mouth.Among the different diluents utilized, it was found that a combination of microcrystalline cellulose PH101 (MCC 101), mannitol, dicalcium phosphate dihydrate (DP

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Karike, Girija *. Koppula Maheshwari B. Anusha Ramya Sri Sura. "FORMULATION AND EVALUATION OF SOLUBILITY ENHANCEMENT OF LOVASTATIN FAST DISSOLVING TABLETS BY USING ION EXCHANGE RESINS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2946–56. https://doi.org/10.5281/zenodo.1231008.

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The present study investigated that the fast dissolving tablets of Lovastatin by ion exchange resin. DRC prepared by physical mixing and solvent evaporation method. Sodium starch glycolate and Crospovidone were used as super disintegrants. Formulations prepared by physical mixing and solvent evaporation blends were taken for pre and post compression studies. Those all found to be within limits. From dissolution data among all formulations I11 formulation containing DRC with solvent evaporation method along with CP as super disintegrant has shown maximum drug release within 10 min. Hence it con

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23

Aleti, Rajeswari, Monika Nijhawan, Sailaja Gunnam, et al. "Investigation of Groundnut Shell Powder as Potential Super Disintegrant in Chronotherapeutic Delivery of Sacubitril–valsartan." Asian Journal of Pharmaceutical Research and Health Care 16, no. 3 (2024): 316–21. http://dx.doi.org/10.4103/ajprhc.ajprhc_71_24.

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ABSTRACT Context: Chronotherapeutic delivery of antihypertensives plays a potential role in the treatment by providing a therapeutic amount of drug at the target site in the body. Sacubitril–valsartan (SV), an angiotensin receptor neprilysin inhibitor, has been indicated for the treatment of hypertension. The study explores the formulation and evaluation of compression-coated tablets (CCTs) of SV using a natural super disintegrant in the core tablet for chronotherapeutic drug delivery. Aim and Objective: The main objective of the current investigation is to study the applicability of groundnut

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24

Aneela Manzoor. "Review article: sodium starch glycolate as a super disintegrant." Journal of Contemporary Pharmacy 5, no. 1 (2021): 33–39. http://dx.doi.org/10.56770/jcp2021515.

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Sodium starch glycolate (SSG) is most widely used excipient in the field of pharmaceutical sciences. SSG is extensively used as a superdisintegrant in different drug formulations. This review article aims to discuss chemistry, synthesis, level used as superdisintegrant, different types of SSG’s and various physicochemical properties. SSG available as different brands i.e Primojel, Explotab and Vivastar with different properties. Excipient, generally considered as an inert component, are of great importance in drug product development. Interchange between different suppliers can lead to final p

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25

Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made

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26

Eraga, S. O., C. M. Okolo, B. U. Odionyenma, C. E. Mbadugha, and M. A. Iwuagwu. "A Comparative Evaluation of Fast Dissolving Tablets of Acetaminophen Using Super-disintegrant Blends and Sublimation Method." Journal of Phytomedicine and Therapeutics 19, no. 1 (2020): 375–86. http://dx.doi.org/10.4314/jopat.v19i1.3.

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Fast disintegrating tablets (FDTs) are gaining prominence as drug delivery systems and emerging as one of the popular and widely accepted dosage forms, especially for the peadiatric and geriatric patients. This study aims to evaluate and compare the tablet properties of fast disintegrating tablets of acetaminophen prepared by super-disintegrant blends and sublimation methods. Two groups of tablets comprising various batches were prepared by wet granulation. Granules batches of one group of tablets (A-G) were prepared with different concentrations of sodium starch glycolate and croscarmellose s

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Eva monica, Rollando Rollando, Rehmadanta Sitepu, Devi Rusvita Khoirul Nisah, Laurensia Nina Irawati, and Sinta Dwi Larasati Listio. "Formulation of Fast Disintegrating Tablet Paracetamol Employing Selected Super-disintegrant." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4323–33. http://dx.doi.org/10.26452/ijrps.v11i3.2648.

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The objective of this research was to investigate paracetamol FDT formula with potato starch and xanthan gum or glycine or ac di sol combination that can produce the best tablet quality. The tablets were prepared by direct compression technique. Superdisintegrant such as Glycine, Ac di sol, Xanthan Gum, and Potato Starch Extract was optimized as 1-19 % on the basis of least disintegration time. Binders such as HPMC were optimized along with optimized superdisintegrant concentration. 3,5% HPMC was selected as optimum binder concentration on the basis of least disintegration time. Granule parame

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Sathali, A. Abdul Hasan, R. Prabhu, P. Rahmathnisha, and S. Ponnammal Asmi. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF TORSEMIDE." International Journal of Pharmaceutical Sciences and Medicine 7, no. 4 (2022): 1–17. http://dx.doi.org/10.47760/ijpsm.2022.v07i04.001.

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Hypertension is a chronic disease that is characterized by a persistently high blood pressure. It can cause strokes, myocardial infarctions, heart failure, and chronic kidney failure if not treated properly. An effort has been made to develop a fast dissolving tablet containing torsemide, which is used in the treatment of hypertension, in enhancing the onset of action, therapeutic response, patient acceptance, and ease of access. Torsemide fast dissolving tablets (FDTs) were prepared by direct compression method using different ratios of super-disintegrants. The prepared tablets were subjected

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Vegesna, Chandini, and J. Anu Pravallika. "Applicability of Raw Banana as Super Disintegrant in the Design of Bupropion HCl Orodispersible Tablets." International Journal of Science and Research (IJSR) 10, no. 11 (2021): 654–59. https://doi.org/10.21275/sr211108175907.

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Bolhuis, G. K., K. Zuurman, and G. H. P. te Wierik. "Improvement of dissolution of poorly soluble drugs by solid deposition on a super disintegrant. II. The choice of super disintegrants and effect of granulation." European Journal of Pharmaceutical Sciences 5, no. 2 (1997): 63–69. http://dx.doi.org/10.1016/s0928-0987(96)00256-4.

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M. Aruna, Samreen, and Shaik Harun Rasheed. "Formulation and evaluation of fast disintegrating tablets of metoprolol succinate using various superdisintegrants." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 79–83. http://dx.doi.org/10.33974/ijrpst.v1i2.150.

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The aim of present work is to develop a fast disintegrating solid oral dosage form of Metoprolol succinate. The concept of fast dissolving drug delivery system emerged from the desire to provide patient with more conventional means of taking their medication. Problems associated with conventional tablets can be resolved by means of fast dissolving tablets when put on tongue these tablets disintegrate and dissolve rapidly in saliva without need of drinking water. The faster the drug disintegrates in to solution, the quicker the absorption and onset of clinical effect. Preformulation results rev

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32

Al-dhahir, Rasha Khalid, and Myasar Al-kotaji. "FORMULATION OF ORALLY DISINTEGRATING TABLETS OF CINNARIZINE BY USING DIRECT COMPRESSION METHOD." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 117. http://dx.doi.org/10.22159/ijap.2019v11i1.29599.

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Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (

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Kumar, R. Santosh, T. Naga Satya Yagnesh, and V. Goutham Kumar. "OPTIMISATION OF IBUPROFEN FAST DISSOLVING TABLETS EMPLOYING STARCH XANTHATE USING 23 FACTORIAL DESIGN." International Journal of Applied Pharmaceutics 9, no. 5 (2017): 51. http://dx.doi.org/10.22159/ijap.2017v9i5.19707.

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Objective: To evaluate starch xanthate as a super disintegrant in the formulation of fast dissolving tablets of poorly soluble drugs employing 23 factorial design.Methods: Starch xanthate was synthesized by gelatinization process. The synthesized starch xanthate was subjected to physical and micromeritic evaluation. To establish as starch xanthate as a super disintegrant, fast dissolving tablet of ibuprofen was prepared employing starch xanthate in different proportions in each case by direct compression method employing 23 factorial design. All fast dissolving tablets prepared were evaluated

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Ponnaganti, Hyma, and Kaveri Anke. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF ACECLOFENAC BY DIRECT COMPRESSION METHOD." Journal of Advanced Scientific Research 13, no. 02 (2022): 142–48. http://dx.doi.org/10.55218/jasr.202213219.

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Nowadays, Oro dispersible tablets are gaining much importance because it is easily approachable and due to its patient compliance. In this study, Formulation and evaluation of one such tablets of Aceclofenac by direct compression method using super disintegrants like Cross carmellose sodium (CCS) was performed. Due to low water soluble property of aceclofenac, it has poor dissolution and bioavailability. In order to minimize this property OTD’s are prepared. ODT’s were prepared by direct compression method using super disintegrant i.e Cross Carmellose Sodium (CCS) in different concentrat

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Putranti, Widyasari, Desty Restia Rahmawati, Nining Sugihartini, and Teuku Nanda Saifullah. "Influence of croscarmellose in fast disintegrating tablet of Syzygium polyanthum extract." International Journal of Public Health Science (IJPHS) 13, no. 1 (2024): 438. http://dx.doi.org/10.11591/ijphs.v13i1.22666.

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Bay leaves (<em>Syzygium polyanthum</em>) contain the flavonoid quercetin which can be used as an antihyperlipidemic drug. The development of antihyperlipidemic drug formula in the form of fast disintegrating tablet (FDT) is needed for patients who experience dysphagia. FDT preparations require an optimal super disintegrant concentration to produce a good drug formula. This study aims to develop the FDT formula of bay leaves extract using the super disintegrant croscarmellose sodium (CCS) intra and extra-granular. FDT formulation using the wet granulation method with variations of

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Putranti, Widyasari, Desty Restia Rahmawati, Nining Sugihartini, and Teuku Nanda Saifullah. "Influence of croscarmellose in fast disintegrating tablet of Syzygium polyanthum extract." International Journal of Public Health Science (IJPHS) 13, no. 1 (2025): 438–46. https://doi.org/10.11591/ijphs.v13i1.22666.

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Bay leaves (Syzygium polyanthum) contain the flavonoid quercetin which can be used as an antihyperlipidemic drug. The development of antihyperlipidemic drug formula in the form of fast disintegrating tablet (FDT) is needed for patients who experience dysphagia. FDT preparations require an optimal super disintegrant concentration to produce a good drug formula. This study aims to develop the FDT formula of bay leaves extract using the super disintegrant croscarmellose sodium (CCS) intra and extra-granular. FDT formulation using the wet granulation method with variations of CCS concentrations; F

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Renuka, Sagane Kiran B. Erande. "Solubility Enhancement, Formulation and Evaluation of Dolutegravir." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 206–13. https://doi.org/10.5281/zenodo.10467952.

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Dolutegravir is an HIV-1 antiviral agent used to control HIV/AIDS. In the present study, Dolutegravir inclusion complexes have been subjected to improvement in solubility and dissolution rate performance by being formulated as immediate release tablets, in which β- CD were used as polymers. Inclusion complexes of dolutegravir were prepared with different ratios of dolutegravir and β-CD (1:0.5, 1:1, and 1:2) by the kneading method. The pre-compression and post-evaluation parameters were studied, and the results were shown. All the results were within acceptable IP limits. Finally, by

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Gandhi, B. R., A. S. Mundada, and K. R. Gandhi. "Evaluation of KYRON T-314 (Polacrillin Potassium) as a novel super disintegrant." International Journal of Drug Delivery 3, no. 1 (2011): 109–14. http://dx.doi.org/10.5138/ijdd.2010.0975.0215.03060.

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Al-Shammary, Sarah Rahman, and Eman Beker Hazim Al-Khedairy. "Formulation and Evaluation of Immediate-Release Oral Tablets Containing Magnesium Aluminum Silicate-Loaded Simvastatin." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 6, no. 2 (2024): 64–69. http://dx.doi.org/10.54133/ajms.v6i2.745.

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Background: Simvastatin (SIM) is a lipid-lowering agent to prevent disorders caused by clogged blood vessels. Because of its low solubility, it has low bioavailability. The adsorption technique is effective in improving drug solubility and dissolution rate. Objective: To use magnesium aluminum silicate (MAS) as an adsorbent in combination with Soluplus® as a hydrophilic polymer to formulate SIM as immediate-release tablets (IRTs). Methods: We used the solvent evaporation method to make MAS-loaded SIM in the presence of Soluplus®, making sure that the ratio of SIM to MAS to SOLU was 1:6:3. We t

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Egla, Mustafa, and Shaimaa N. Abd Al Hammid. "DESIGN ZOLMITRIPTAN LIQUISOLID ORODISPERSIBLE TABLETS AND THEIR IN VITRO EVALUATION." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 1 (2016): 297. http://dx.doi.org/10.22159/ijpps.2017v9i1.15656.

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<p><strong>Objective: </strong>The objective of present study is to develop orodispersible tablets (ODTs) of zolmitriptan by liquisolid technique using different types of super disintegrants to enhance the disintegration and dissolution of zolmitriptan to improve the bioavailability of the drug.</p><p><strong>Methods: </strong>Liquisolid ODTs of zolmitriptan were prepared from; microcrystalline cellulose (Avicel PH-102) as carrier, colloidal silicon dioxide (Aerosil 200) as a coating material, croscarmellose sodium (CSS), sodium starch glycolate (SSG),

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Bavaskar, Kedar Rupa, Supriya Pote, Prasad Vidhate, Vinit Patil, and Ashish Jain. "Preparation and Evaluation of Mouth Dissolving Tablet of Albendazole Using Different Concentrations of Super-Disintegrant." Journal of Fundamental and Applied Pharmaceutical Science 4, no. 2 (2024): 81–92. http://dx.doi.org/10.18196/jfaps.v4i2.19148.

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Anthelmintic medications are anticipated to act more quickly and have greater absorption. Mouth-dissolving albendazole tablets were created using a direct compression approach and a mixture of super disintegrants to accomplish rapid disintegration of the tablets in the oral cavity. The preparation of ten batches of mouth-dissolving tablets using different grades of Kollidon, crospovidone, sodium starch glycolate, and croscarmellose sodium as super disintegrants produced the greatest results. For a compatibility investigation, FTIR was used to characterize the drug and physical mixture. An opti

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Akula, Priyanka. "Formulation and Evaluation Oral Dispersible Tablets of Vidarabine." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 36–47. https://doi.org/10.5281/zenodo.10099936.

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<strong>Abstract</strong>In the present work, taste masking of Vidarabine was carried out by using HP-β-CD inclusion complex. These taste-masked complexes were further formulated into the Oro dispersible tablet by the direct compression method using Ac-Di-Sol and Avicel as a super disintegrant. Vidarabine is used in the treatment of AIDS. This research has described the production of a taste masked dosage form from initial determination of threshold bitterness concentration of the pure drug through to the development of a final taste masked prototype formulation. It was found that the taste ma

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Karim, S., A. Biswas, A. Bosu, F. R. Laboni, A. S. Julie, and M. H. O. Rashid. "Effect of Sodium Starch Glycolate on Formulation of Fexofenadine Hydrochloride Immediate Release Tablets by Direct Compression Method." Journal of Scientific Research 10, no. 1 (2018): 31–38. http://dx.doi.org/10.3329/jsr.v10i1.32703.

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Present study aspires at the design of an immediate release formulation with prospective use of fexofenadine hydrochloride by exploring the effect of sodium starch glycolate as super disintegrant. Fexofenadine hydrochloride immediate release tablets (Formulations F-1, F-2, F-3, F-4 and F-5) using different ratios of sodium starch glycolate as a disintegrant were prepared by direct compression method. Standard physicochemical tests were performed for all the formulations. Dissolution studies of the formulations were done in phosphate buffer, pH 6.8 using USP apparatus II (paddle apparatus) at 5

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Hitesh Jain, Vimla Chaudhary, Vaishnavi Kamath, Dipal Prajapati, and D. B. Meshram. "Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine." GSC Biological and Pharmaceutical Sciences 22, no. 1 (2023): 345–50. http://dx.doi.org/10.30574/gscbps.2023.22.1.0039.

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Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine. Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio. Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD. After select

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Anabousi, Suhad, Hani Naseef, Moammal Qurt, Abdallah AbuKhalil, and Abdullah Rabba. "Fast disintegrating pellets: Formulation and evaluation." F1000Research 14 (July 21, 2025): 711. https://doi.org/10.12688/f1000research.165282.1.

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Background Extrusion-spheronization is the most commonly used technology to produce pellets using microcrystalline cellulose as a pelletizing agent. However, it has the major drawbacks of lack of disintegration and prolonged drug release. This study aimed to develop rapidly disintegrating microcrystalline cellulose-based pellets. Methods Several pellet formulations were prepared via extrusion spheronization using a combination of microcrystalline cellulose, mannitol, polyethylene glycol 400(PEG 400), polyplasdone (PPXL), and croscarmellose sodium (CCS). Subsequently, they were evaluated for th

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Draksiene, Gailute, Brigita Venclovaite, Lauryna Pudziuvelyte, Liudas Ivanauskas, Mindaugas Marksa, and Jurga Bernatoniene. "Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation." Pharmaceutics 13, no. 6 (2021): 879. http://dx.doi.org/10.3390/pharmaceutics13060879.

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The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.

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Jabir, Saba Abdulhadee, and Halah Talal Sulaiman. "PREPARATION AND CHARACTERIZATION OF LAFUTIDINE AS IMMEDIATE RELEASE ORAL STRIP USING DIFFERENT TYPE OF WATER-SOLUBLE POLYMER." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 249. http://dx.doi.org/10.22159/ijap.2018v10i5.28292.

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Objective: The objective of the present study was to design and optimize oral fast dissolving film (OFDF) of practically insoluble drug lafutidine in order to enhance bioavailability and patient compliance especially for a geriatric and unconscious patient who are suffering from difficulty in swallowing.Methods: The films were prepared by a solvent casting method using low-grade hydroxyl propyl methyl cellulose (HPMC E5), polyvinyl alcohol (PVA), and sodium carboxymethyl cellulose (SCMC) as film forming polymers. Polyethylene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as

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Shanmugam, S., Dr Senthil, and T. Ventrichelvan. "Formulation and evaluation of loratadine mouth dissolving tablet." Bangladesh Journal of Scientific and Industrial Research 48, no. 2 (2013): 137–42. http://dx.doi.org/10.3329/bjsir.v48i2.15745.

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Loratadine 10 mg mouth dissolving tablet (MDT) was prepared by using super disintegrant such as sodium starch glycollate, crosscarmellose sodium, crospovidone at various concentration, aspartame was used as sweetening agent. The excipients were used for this study was based on the compatibillity studies. All the formulation was prepared by direct compression method. Among all the formulations crospovidone at 10 mg/tab gives 99.1% drug release at end of 12th min. It was considered as optimized batch. The optimized batch was processed for all the evaluation parameter and stability studies. The f

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Hersen-Delesalle, Christine, Bernard Leclerc, Guy Couarraze, Virginie Busignies, and Pierre Tchoreloff. "The Effects of Relative Humidity and Super-Disintegrant Concentrations on the Mechanical Properties of Pharmaceutical Compacts." Drug Development and Industrial Pharmacy 33, no. 12 (2007): 1297–307. http://dx.doi.org/10.1080/03639040701384918.

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Yang, Shicheng, Yurong Fu, Seong Hoon Jeong, and Kinam Park. "Application of poly(acrylic acid) superporous hydrogel microparticles as a super-disintegrant in fast-disintegrating tablets." Journal of Pharmacy and Pharmacology 56, no. 4 (2004): 429–36. http://dx.doi.org/10.1211/0022357023015.

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