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Journal articles on the topic 'Super Disintegrates'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Sneha, Ms Shinde. "Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 04 (2024): 1–5. http://dx.doi.org/10.55041/ijsrem30535.

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Nowadays, the administration of drugs through the oral route is becoming less common, accounting for only about 75% of all drug administrations compared to other routes. A new type of dosage form called oral disintegrating tablets has gained popularity in recent decades due to their rapid disintegration and dissolution. These tablets disintegrate in the mouth within seconds (25-40 seconds) without the need for water, as the oral mucosa alone is sufficient for the tablet to dissolve. The selection of a suitable disintegrating agent is crucial to achieve optimal bioavailability. A preparation ma

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2

Iswariya, V. T., Nambaaru Sailaja, CH Vamsi Krishna, and G. S. Annammadevi. "Natural Super-Disintegrant Agents Used in Various Oral Solid Dosage Forms." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 110–13. http://dx.doi.org/10.22270/jddt.v11i1.4681.

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Super-disintegrating agents are one of the ingredients used in pharmaceutical solid dosage forms. These substances play a vital role in formulation design. Natural super-disintegrants have gained more popularity due to their oral bioavailability. It disintegrates the tablets into smaller particles to enhance the dissolution rate. Fast dissolving, chewable tablets, and other orally administered dosage forms consist of super-disintegrating agents which shows rapid and quick action. Natural super disintegrating agents in pharmaceutical dosage forms are very effective due to their ecofriendly natu

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3

Sujit, S. Shinde* Madan k. Shinde Avinash A. Bhagat Sachitanand Balaji Biradar. "Formulation And Evaluation Of Fast Dissolving Sodium Diclofenac Sodium Tablet." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1761–74. https://doi.org/10.5281/zenodo.11400826.

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The present study was aimed to formulate, evaluate, and optimize a tablet that disintegrates and dissolved rapidly toshow a rapid onset action. Diclofenac sodium, non-steroidal- inflammatory, analgesic, and pyretic properties were selected asa model drug. Diclofenac sodium is among the most extensivelyused Non-steroidal anti-inflammatory drugs, employed inmucosal skeletal complaints, especially arthritis. In the present study, an attempt has been made to prepare fast dissolvingtablets of diclofenac sodium using super disintegrants like sodium starch Glycolate, Croscarmellose sodium, Crospovido

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4

Bhattacharya, Suhasis, Tanmay Mohanta, Sujit Das, and Rumpa Basak. "Orodispersible Tablet in Treatment of Migraine: Opportunities, Challenges and Recent Advancements." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 149–56. http://dx.doi.org/10.22270/jddt.v11i4.4878.

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The most comfortable and choicely path of drug administration is oral route. Orodispersible tablets bring a revolution among all routes of drug administration as well as oral route of drug administration also. Orodispersible tablets are unit dosage form but it has unique characteristics. It disintegrates in the mouth within a minute for the presence of saliva where the presence of super disintegrates in the preparation. Especially, old and child have no chance to swallow as a result it is very acceptable for them. Migraine is a very well-known irritating condition for adult and female. Migrain

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5

K, Venkatesh, Ramu B, and Rajkamal B. "Formulation and Evaluation of Risperidone Fast Disintegrating Tablets by Using Co- processed Superdisintegrants." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 334–42. https://doi.org/10.5281/zenodo.13754623.

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In the present work, an attempt has been made to develop fast disintegrating tablets of Risperidone. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the

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M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.

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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wet

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7

C., Haranath* T. Srikanth M. Suresh Krishna G. Chaithanya Barghav C. Mahesh Reddy. "FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 10790–99. https://doi.org/10.5281/zenodo.3229226.

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<em>Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carme

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8

Nimisha Solanki, Arpit Gawshinde, Komal Tikariya, Umesh K. Atneriya, and Dharmendra Solanki. "A Review on Orodispersible tablet." IJPAR JOURNAL 12, no. 3 (2023): 358–61. http://dx.doi.org/10.61096/ijpar.v12.iss3.2023.358-361.

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The oral route is the most important and recommended route of drug administration. Oral route is the safest and convenient route of drug delivery because of wide range of drugs are administered through this route. Oro dispersible tablets are novel oral drug-delivery system as they have improved patient compliance and have some additional advantages compared to other oral formulation. Oral dispersible tablet are solid unit dosage forms, which disintegrate or dissolves quickly in the mouth within a minute in the presence of saliva without chewing or water. The dosage form containing super disint

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9

M. Aruna, Samreen, and Shaik Harun Rasheed. "Formulation and evaluation of fast disintegrating tablets of metoprolol succinate using various superdisintegrants." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 79–83. http://dx.doi.org/10.33974/ijrpst.v1i2.150.

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The aim of present work is to develop a fast disintegrating solid oral dosage form of Metoprolol succinate. The concept of fast dissolving drug delivery system emerged from the desire to provide patient with more conventional means of taking their medication. Problems associated with conventional tablets can be resolved by means of fast dissolving tablets when put on tongue these tablets disintegrate and dissolve rapidly in saliva without need of drinking water. The faster the drug disintegrates in to solution, the quicker the absorption and onset of clinical effect. Preformulation results rev

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10

Nandhini M, Voleti Vijaya Kumar, Suganya T, et al. "Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 3 (2024): 239–44. http://dx.doi.org/10.18231/j.ijpca.2024.034.

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The needof the fast-disintegrating tablets ever increasing day by day during the last decade. In this current research study, the effect of the natural super disintegrating agents in the Dapsone fast disintegrating tablets was compared. The natural super disintegrating agents were characterized for different physico chemical methods like Loss on drying, moisture content and Ash values.Dapsone was selected as a model drug, where the dapsone has low bioavailability due to this reason, dapsone solid dispersions were developed and the same was used to formulate the tablets. The formation of the so

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11

Chandrasekar, R., Prudhvi Raj V, and Sameer Shaik. "Formulation Development and Invitro Evaluation of Gliclazide Pellets using Superdisintegrants by Extrusion Spheronization Technique." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 1 (2023): 6266–80. http://dx.doi.org/10.37285/ijpsn.2023.16.1.2.

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Introduction: Gliclazide is a sulfonylurea derivative used for the treatment of type 2 Diabetes, it is an anti-diabetic drug it is marketed under the brand name Diamicron. It is taken orally and used when dietary changes, lack of exercise, and weight loss are not sufficient.  Aim: The principal objective of this work was to develop, formulate and evaluate the pellet formulations prepared with the incorporation of different super disintegrants in different ratios and in different combinations. In this research work, the drug gliclazide was chosen as a model drug and it was formulated into

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12

Krishna, Pandey Manju, and Gupta Amresh. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. https://doi.org/10.5281/zenodo.13120020.

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The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are

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13

Rao.S, Kameswara, Yusuf MD., Saraswathi P., Ch R. Raghavendra Rao, Murali P., and Vijayakumar V. "Formulation and evaluation of orodispersible Enalapril maleate tablets: a comparative study on natural super disintegrents and synthetic super disintegrents." International Journal of Advances in Scientific Research 1, no. 7 (2015): 313. http://dx.doi.org/10.7439/ijasr.v1i7.1821.

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The aim of the present investigation is to formulate Enalapril maleate oral disintegrating tablet by using natural and synthetic superdisintegrents..ODTs may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first-pass hepatic metabolism and potentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The objectives of the research work is to formulate oral disintegrating tablets of Enalapril maleate by using different super disintegrates(Natural, Synthetic) in different ratio

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14

Ramesh, Pastham, Reddy Sunil, and Allenki Venkatesam. "Design and In-vitro Evaluation of Enteric Coated Pulsatile Drug Delivery System of Zileuton Tablets." Pharmaceutical and Chemical Journal 4, no. 4 (2017): 57–65. https://doi.org/10.5281/zenodo.13785001.

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In the present research work pulsatile drug delivery system of Zileuton tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by 30% concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopo

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15

Prabhat, Shrestha, Shrestha Rajan, and Shrestha Sahana. "Formulation and evaluation of orally disintegrating tablet containing taste masked mirtazapine." Journal of Analytical & Pharmaceutical Research 10, no. 2 (2021): 71–80. http://dx.doi.org/10.15406/japlr.2021.10.00368.

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Objective: This study aims to prepare the taste-masked granules of Mirtazapine by mass extrusion technique and formulate it into an oral dispersible tablet using different super disintegrates. Methods: Taste masked granules of mirtazapine were prepared by mass extrusion technique using Eudragit EPO in different ratios. The drug-polymer ratio was optimized based on the percent drug release in SSF and SGF. Taste masking efficacy of drug-polymer complex was determined by developing the bitterness threshold value of Mirtazapine. The selected drug-polymer complex was formulated into an oro-dispersi

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16

Lakshmana, Rao P., Rao M. Prasada, Prasanna A. Lakshmi, Babu G. Sagar, J. Bhargavi, and N. Praveen. "Formulation and Evaluation of Sumatriptan Succinate Oral Disintegrating Tablets Using Super Disintegrants." Journal of Molecular Pharmaceuticals and Regulatory Affairs 1, no. 1 (2019): 23–34. https://doi.org/10.5281/zenodo.2629934.

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<em>The main objective of this research work is to formulate and evaluate the oral disintegrating tablets of sumatriptan succinate </em><em>to provide faster relief from pain to migraine sufferers. The formulations were optimized by incorporating varying composition of croscarmellose sodium and treated agar as super disintegrates. All the excipients are tested for compatibility with model drug, which revealed that there was no physical and chemical interaction occurred. The blend of each formulation was evaluated for precompression parameters before compression. The tablets are prepared by dir

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17

Desu, Prasanna Kumar, Brahmaiah Bonthagarala, and Pasam Venkateswara Rao. "Formulation and evaluation of Nateglinide dispersible tablet by direct compression method." International Journal of Advances in Scientific Research 1, no. 1 (2015): 51. http://dx.doi.org/10.7439/ijasr.v1i1.1784.

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The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide.Nateglinideis adrugfor the treatment oftype 2 diabetes. The present study is an attempt to select best possible combination of diluents and disintegrates to formulate dispersible tablet of Nateglinide which disintegrates within few minutes thereby reducing the time of onset of action. Mannitol is selected as diluents, Sodium starch glycol ate, Cross-povidone, cross-carmellose sodium were selected as super disintegrates, citric acid and sodium bi carbonate is effervescent active ingredient in di

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18

Megha, Pandey* Dr. Shilpa Gawande Dr. A. V. Chandewar. "Formulation And Development of Oral Fast Dissolving Tablets Using a Model Drug." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3892–905. https://doi.org/10.5281/zenodo.15493439.

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The aim of this study was to develop fast dissolving tablets of cinnarizine by direct compression method. Micro crystalline cellulose (MCC) as diluent and super disintegrants, such as Crospovidone (CP), Cinnarizine(drug), Magnesium Stearate,Talc,Mannitol and croscarmellose Sodium were used. Fast dissolving tablets disintegrates or dissolves rapidly within few seconds due to maximized pore structure in the formulation or by the action of superdisintegrants. Infrared (IR) spectroscopy was performed to identify the physicochemical interaction between drug and polymer. IR spectroscopy showed that

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19

Mhetre, Raksha L., Pratiksha S. Kadam, Pradyna H. Gadhire, Gauri Lajurkar, Aditee D. Kagde, and Shashikant N. Dhole. "Formulation and Evaluation of Naproxen Orodispersible Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 4 (2022): 6055–60. http://dx.doi.org/10.37285/ijpsn.2022.15.4.5.

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Background: In the treatment of variant disease, oral administration is the main choice in society, especially in children. Orodispersible tablets have been more popular among children in recent years than oral liquid dosage forms. An Orodispersible tablet disintegrates in the oral cavity and the drug gives pharmacological and therapeutically responses as the faster onset of action.  Purpose of the study: Naproxen is a nonsteroidal anti-inflammatory drug that is used to treat mild to moderate pain and arthritis. In this study, super disintegrant agents Crospovidone and Croscarmellose Sod

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20

Kumar, Damit, Amit Sharma, and Rajiv Garg. "FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF LOSARTAN POTASSIUM." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 54–66. http://dx.doi.org/10.22270/ajprd.v6i4.386.

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The objective of the current study was to develop and optimize a sublingual tablet of Losartan potassium, which is an effective drug in the treatment of hypertension. Owing to number of advantages dissociated with the quick onset of action and it by passes the liver. Sublingual tablets offer effective and easier way for management of Hypertension. The basic approach used in development of Sublingual tablet was the use of super disintegrants by direct compression method. Oral mucosal drug delivery is one of the promising method of systemic drug delivery which offers several advantages. The lite

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21

Siva, Sindhura.P, and Duraivel.S. "Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride." International Journal of Current Pharmaceutical Review and Research 3, no. 4 (2013): 105–9. https://doi.org/10.5281/zenodo.12691260.

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The present study aims at developing a Gastroretentive swellable and floating matrix tablet formulation ofciprofloxacin hydrochloride for the effective treatment of infections caused by susceptible organisms.Ciprofloxacin hydrochloride is a fluoroquinoline antibiotic drug. Ciprofloxacin HCl is more stable in acidicmedium and it has a narrow absorption window which is sited at stomach and proximal portions of the smallintestine, so it fulfils the required criteria for selection of drug for Gastroretentive dosage form. CiprofloxacinHCl Gastroretentive tablets were formulated by using wet granula

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Mangilal, Teelavath, and Shiva Kumar Y. "Formulation and In Vitro Evaluation of Bilayered Matrix Tablets of Pioglitazone for Immediate Release and Glimepiride for Extended Release." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 6 (2018): 4348–54. http://dx.doi.org/10.37285/ijpsn.2018.11.6.8.

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Bi-layer tablets are novel drug delivery systems where a combination of two or more drugs in a single unit having different release profiles which improves patient compliance and prolongs the drug action. The study was performed to design bilayer matrix tablets of pioglitazone for immediate release and glimepiride for extended release delivery system. Bilayered matrix tablets composed of two layers, one is immediate release and a second layer is extended release layers. The immediate release layer comprised sodium starch glycolate, and croscarmellose sodium as super disintegrates and extended

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Chauhan, Kalindi, Rakesh Solanki, and Shivani Sharma. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 1. http://dx.doi.org/10.22159/ijap.2018v10i6.28134.

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In the present scientific scenario, the drug delivery technology has become extremely competitive and quickly evolving with ever-increasing demand. Fast dissolving tablet (FDT) is one such style of an innovative and distinctive drug delivery system. Once FDT is placed on the tongue, it disintegrates or dissolves quickly (in seconds) without chewing or water. Fast dissolving pills became well-liked because of higher patient compliance and most popular over typical capsules and tablets. Numerous FDT products entered the market in the nineteen eighties. This novel drug delivery like FDT or mouth

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Gupta, Anil K., Charanjeet Singh, Yashwant ., and Kamal . "Formulation Optimization and Evaluation of Orally Disintegrating Tablets of Moxifloxacin." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1658–62. http://dx.doi.org/10.25258/ijddt.12.4.30.

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Oral administration of a pharmacologically active agent is the common and most preferred route among patients suffering from different types of illness. In the market, different type of oral dosage form is available among them tablet is the most favorite and demanded formulation. Further, the tablets, which are easy to use and swallow, are the ideal dosage form like orally disintegrating tablets (ODT’s). The main advantage of this type of formulation is that they can give easily to old aged and under-aged patients. In this research work, ODT’s formulation was manufactured, which get easily dis

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Nagendra, R.1 Anusha B. H.2* Venkatesh K.3 Hanumanthachar Joshi4 Tanuja A. . J.5. "Innovations in Fast Disintegrating Tablet Formulation: Harnessing the Power of Super disintegrants for Rapid Oral Dissolution." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 380–91. https://doi.org/10.5281/zenodo.10673308.

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This work looks into how to improve the oral dissolving qualities of fast disintegrating tablets (FDTs) by formulating and testing them using cutting-edge super disintegrants. Modern super disintegrants have the ability to dissolve and disintegrate quickly in FDTs, which could be advantageous for patient convenience and compliance. To maximize tablet disintegration times, a variety of super disintegrants were used, such as sodium starch glycolate, crospovidone, and croscarmellose sodium. Excipients such binders, diluents, and sweeteners were carefully chosen to ensure compatibility and maintai

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Harshal, Gosavi* Dr. Avish Maru Jayshree Bhadane Nilesh Pawar. "Formulation And Evaluation Fast Disintegrating Tablet: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2257–69. https://doi.org/10.5281/zenodo.15407833.

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The pharmaceutical industry's demand for fast disintegration tablets (FDTs) has grown over the last few years, and the field is growing quickly. Fast dissolving tablets (FDTs) are solid dosages that dissolve rapidly on the tongue and absorb the drug with the need for water in a few seconds. FDTs have been developed for bedridden, elderly, and paediatric patients as well as active individuals who are on the go and may not having access to water. Due to hand tremors and dysphasia, many older people will have trouble swallowing traditional oral dosage forms, including tablets, capsules, and solut

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Roman, Vaishnavi* Gaikwad Rutuja. "Development And Characterization of Lornoxicam Tablets Incorporating Banana Starch as A Superdisintegrating for Enhanced Dissolution." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2058–63. https://doi.org/10.5281/zenodo.15232534.

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Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate

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Divya, B., J. Sreekanth, and D. Satyavati. "Development of Extended Release Formulations of Ilaprazole Tablets." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 8–12. http://dx.doi.org/10.22270/jddt.v9i3.2811.

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Extended release products are designed to release their medication in a controlled manner at a predetermined rate, duration, and location to achieve and maintain optimum therapeutic blood levels of a drug. The objective of the study is to formulate and evaluate Ilaprazole Controlled release tablets comparable to the innovator product. F1-F9 formulations were prepared using varying concentrations of super disintegrates like Crospovidone, Croscarmellose sodium and Sodium starch glycolate in different concentrations. Based on the hardness, friability, weight variation, drug content, F6 formulatio

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Patel, Sarvesh, Jai Narayan Mishra, and Dhaneswar Kumar Vishwakarma. "FORMULATION DEVELOPMENT AND CHARACTERIZATION OF FAST DISSOLVING TABLET OF ATENOLOL BY DIRECT COMPRESSION METHOD." International Journal of Advanced Research 9, no. 10 (2021): 1277–86. http://dx.doi.org/10.21474/ijar01/13678.

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Finally in the project work Atenolol is an anti-hypertensive drug. It has been formulated into fast dissolving tablets by direct compression method by using the Excipients like lactose, sucrose magnesium stearate, sodium lauryl and sulphate and many type super disintegrates such as crosscarmellose and sodium starch glycolate and the prepared by the tablets were evaluated for the pre-compression parameter such as angle of repose, bulk density, tapped density, % index, Hausners ratio, partition coefficients, melting points, UV spectroscopy, % assay, TLC, loss on drying and post compression param

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Mansuri, Toshib* Adnan Siddiqui Sk Shehzad Sohel Khan Mayur Gokul Jayswal Bagwan Wasim Dr. Rehan Deshmukh. "Development And Evaluation Of Pressed Coated Floting Pulsatile Tablet Of Atenolol." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 13–21. https://doi.org/10.5281/zenodo.8396445.

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Atenolol is an Synthetic Beta-1 selective blocker, primarily used in management of hypertension and Chronic angina and to reduce mortality in known or suspected myocardial infarction. It belongs to BCS class III having a half-life of 7hrs and 50% bioavailability.  The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of Atenolol as an antihypertensive agent. The prepared system was composed of two components: an active ingredient-containing core tablet and an erodible outer shell with a gas-producing agent. The active compon

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Ahmed, Mohd Salman, Nikita Upadhyay, and P. K. Dubey. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 37–47. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.004.

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Fast dissolving tablets (FDTs) emerged as one of the popular and widely accepted dosage forms. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia) resulting many incidences of non-compliance and making the therapy ineffective. Specifically for paediatric patients because of incomplete development of the muscular and nervous system and case of geriatric patients suffering from Parkinson’s disorder. Oral dosage form and oral route are the most preferred administration route for various drugs with limitations like first-p

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Jabir, Saba Abdulhadee, and Halah Talal Sulaiman. "PREPARATION AND CHARACTERIZATION OF LAFUTIDINE AS IMMEDIATE RELEASE ORAL STRIP USING DIFFERENT TYPE OF WATER-SOLUBLE POLYMER." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 249. http://dx.doi.org/10.22159/ijap.2018v10i5.28292.

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Objective: The objective of the present study was to design and optimize oral fast dissolving film (OFDF) of practically insoluble drug lafutidine in order to enhance bioavailability and patient compliance especially for a geriatric and unconscious patient who are suffering from difficulty in swallowing.Methods: The films were prepared by a solvent casting method using low-grade hydroxyl propyl methyl cellulose (HPMC E5), polyvinyl alcohol (PVA), and sodium carboxymethyl cellulose (SCMC) as film forming polymers. Polyethylene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as

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M, Nandhini, Vijaya Kumar Voleti, Ramesh Yamuna, et al. "Applications of the Natural Polymers for Fast Dissolving Tablets." International Journal of Clinical Pharmacokinetics and Medical Sciences 4, no. 1 (2024): 34–40. http://dx.doi.org/10.26452/ijcpms.v4i1.584.

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Oral route is the safest, most convenient, and economical route for administration of different drugs. Oral disintegrating tablets becoming very popular in the current scenario, as they facilely disintegrated in mouth within fewseconds of the time after its administration withoutthe need of water. Conventional dosage form has a limitations like dysphagia (arduousness in swallowing), in pediatric and geriatric patients, which have been overcome by oral disintegrating tablets. To prepare the same super disintegrating agents plays vital role. Natural Super disintegrants gained an advantage over t

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J, Nandhini, B. Anandhi, Soumya Stuti Patnaik, et al. "Design and Development of Propranolol HCl Fast Dissolving Tablets by Using Isolated Mucilage of Salvia Hispanica for the Treatment of Hypertension by Using DoE tools." Chinese Journal of Applied Physiology 40 (2024): e20240025. http://dx.doi.org/10.62958/j.cjap.2024.025.

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The main issue with Hypertension therapy is quick commencement of effect. The creation of suitable dose forms may help address the issue of medications having a delayed beginning of effect. Oral Antihypertensive medication treatment is best suited for and has seen a rise in popularity with fast-disintegrating tablets. In terms of patient compliance, quick start of action, precise dosage, strong chemical stability, ease of self-administration, and compactness, they are superior to other traditional methods. As a popular hypertension medication, Propranolol HCl is a strong candidate for developm

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Gunda, Raghavendra Kumar, and Naga Suresh Kumar Jujjuru. "Formulation Development and Evaluation of Moxifloxacin.HCL Fast Dissolving Tablets." Pharmaceutical Methods 8, no. 2 (2017): 01–08. https://doi.org/10.5281/zenodo.14854911.

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The main objective of present research investigation is to formulate the Moxifloxacin.HCl Fast Dissolving tablets. Moxifloxacin.HCl, a synthetic fluoroquinolone antibacterial agent, and used to treatacute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis. The Fast Dissolving tablets of Moxifloxacin.HCl were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Superdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected a

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Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made

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Akshay Kumar S, Gowda D V, Sharadha M, and Akhila A R. "The insights on Oro-dispersible tablet." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 260–73. http://dx.doi.org/10.26452/ijrps.v11i1.1815.

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Orodispersible tablets (ODTs) were the conventional product that disintegrates or dissolves into the buccal mucosa in less than 1mins in the absence of water and without chewing. They were first acquainted with the market during the 1980s, and end up one of the quickest developing subdivisions of the oral medication conveyance industry and their items are creating at an extraordinary rate. New orodispersible tablet innovations address numerous pharmaceutical and need of patients, extending from upgraded life-cycle the executives for reasonable medicating for pediatric, aged, and mental patient

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Singh, Harmanpreet, Pooja Jaiswal, Suksham Gupta, and Simerjit Singh. "FORMULATION OF RIZATRIPTAN BENZOATE SUBLINGUAL TABLETS PREPARED BY DIRECT COMPRESSION WITH DIFFERENT BIOADHESIVE POLYMER: IN VITRO AND EX VIVO EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 36. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21334.

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Objective: The current investigation deals with formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate (RTB) to produce its intended therapeutic effect for acute treatment of migraine. When the drug is given by sublingual route, it overcomes the first pass metabolism and quick entry of drug in systemic circulation is obtained. It would result in fast pharmacological response hence faster relief from migraine which is an important criterion in migraine therapy.Methods: In this study, RTB sublingual tablets were prepared using direct compression process usin

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Mane, Swapna, Ritesh Bathe, and Sandhyarani Awatade. "Formulation and Evaluation of Fast Disintegrating Tablets of Atenolol Using Natural and Synthetic Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 150–58. http://dx.doi.org/10.22270/jddt.v9i2-s.2476.

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Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The aim of the present research is to formulate Atenolol fast disintegrating tablets. Atenolol is β1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart. The conventional tablets of atenolol are reported to exhibit f

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Kute, S. Shivaji*1 Sonwane Sonali S*2 Jadhav Vaibhav A2. "Super Disintegrants: An Overview." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 77–89. https://doi.org/10.5281/zenodo.10464297.

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Disintegrants play a crucial role as excipients in solid oral formulations. In immediate release and oral dispersible tablet formulations, super disintegrants like croscarmellose sodium, sodium starch glycolate, crospovidone, and polacrilin potassium are added in small quantities to counteract the effects of compression and binder after administration. The hygroscopic nature of these super disintegrants facilitates the penetration of water into the tablet matrix, while their cross-linkage reduces solubility in water. This article provides an overview of various factors that can influence the f

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Saniya, Mubarik*1 Rajni Dubey2 Bhaskar Kumar Gupta3 Mariya Beg4. "A Research Article: Formulation and Evaluation of By-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2797–809. https://doi.org/10.5281/zenodo.15099861.

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Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using sodium starch

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Agam, Kumar Chaubey* Ashok Baghel Dinesh Sharma Yogendra Singh. "Formulation And Evaluation of Bi-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 501–13. https://doi.org/10.5281/zenodo.14993024.

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The pharmacokinetic advantage relies on the criterion that, drug release from the fast-releasing layer leads to a sudden rise in the blood concentration. However, the blood level is maintained at steady state as the release from sustained layer. Particularly bilayer tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation, and release profile. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing.4 Tablets are solid dosage forms containing medicinal s

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Raziya, Begum Sheikh. "Development and Assessment of Naproxen Mouth Dissolving Tablets." medtigo Journal of Pharmacology 1, no. 1 (2024): e13377773. https://doi.org/10.5281/zenodo.13377773.

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The market demand for orally disintegrating tablets has experienced a significant surge over the past decade. This intervention is particularly beneficial for geriatric and pediatric patients who experience challenges in ingesting traditional tablets and capsules. The utilization of a fast dissolving or fast disintegrating dosage form confers advantages to patients in this context. Fast dissolvable or fast disintegrating dosage forms are designed to rapidly disintegrate upon exposure to saliva, resulting in accelerated drug release within the oral cavity. The administration of fast-disintegrat

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Prachi, Pawar* Akanksha Jadhav Gayatri Ghodke Vidya Anap Dr. Sanjay Ingale. "Review On Fast Dissolving Tablets." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1748–60. https://doi.org/10.5281/zenodo.14011672.

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The fast dissolving tablet (FDT) is a new and unique drug delivery system that is rapidly focusing major  attention in the reasearch field of fast dissolving technology. In recent times, a few solid dosage forms, such as tablets and capsules, are dealing with issues such dysphagia, which causes difficulties  swallowing and leads to a high rate of non-compliance, ultimately causing the therapy  ineffective.Fast dissolving tablet are disintegrating or/and dissolve quickly without the need of water. These tablets are designed to dissolve or break down in saliva in the mouth, u

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Baijnath, Pal* Kavita Lovanshi Rita Mourya. "A Review on Fast Dissolving Tablet." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3147–53. https://doi.org/10.5281/zenodo.15295648.

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The most common and preferred route of drug administration is through the oral route. Fast Dissolving tablets are gaining importance among novel oral drug-delivery system as they have improved patient compliance and have some additional advantages compared to other oral formulation. They are also solid unit dosage forms, which disintegrate in the mouth within a minute in the presence of saliva due to super disintegrants in the formulation. Thus this type of drug delivery helps a proper peroral administration in pediatric and geriatric population where swallowing is a matter of trouble. Various

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Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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Tamer, Manar Adnan, Shaimaa Nazar Abd-al Hammid, and Balqis Ahmed. "FORMULATION AND IN VITRO EVALUATION OF BROMOCRIPTINE MESYLATE AS FAST DISSOLVING ORAL FILM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 7. http://dx.doi.org/10.22159/ijap.2018v10i1.22615.

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Objective: The aim of this study was to formulate and in vitro evaluate fast dissolving oral film of practically insoluble bromocriptine mesylate to enhance its solubility and to improve its oral bioavailability by avoiding first pass effect as well as to produce an immediate release action of the drug from the film for an efficient management of diabetes mellitus type II in addition to an improvement of the patient compliance to this patient-friendly dosage form.Methods: The films were prepared by the solvent casting method using hydroxypropyl methylcellulose of grades (E3, E5, E15), polyviny

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Sahoo, Suvendu, and Samyuktha Metta. "An Exploration of The Potential of Natural Super Disintegrating Agents in Pharmaceutical Formulations: A Review." Journal of Pharmacological and Pharmaceutical Research 1, no. 1 (2024): 21. http://dx.doi.org/10.5455/jppr.20240107023841.

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This review delves into the use of natural super disintegrating agents in pharmaceutical drug formulations. Disintegrants are incorporated into these formulations to aid in breaking down tablets and capsules, promoting rapid dissolution by facilitating their dispersion into smaller particles. Super disintegrants, distinguished by their notable swelling capacity, play a pivotal role in expediting drug disintegration within the gastrointestinal tract. The selection of an appropriate super disintegrant hinges on several factors, including chemical compatibility, swelling potential, disintegration

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Akash S Ingale, Sandhya S Ahire, Sujeetkumar I Ahire, and Parag R. Patil. "Formulation and evaluation of fast dissolving tablets of captopril." GSC Biological and Pharmaceutical Sciences 17, no. 2 (2021): 123–30. http://dx.doi.org/10.30574/gscbps.2021.17.2.0338.

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Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. The development of enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in the mouth are very promising for the delivery of high molecular weight protein and peptide. Good mouth feel property of MDDS helps to change the basic view of medication as “bitter pill”, particularly for pediatric patients. To prepare mouth dissolving tablet using SSG & CCM by using Antihypertensive as m

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Akash, S. Ingale, S. Ahire Sandhya, I. Ahire Sujeetkumar, and Parag R. Patil Dr. "Formulation and evaluation of fast dissolving tablets of captopril." GSC Biological and Pharmaceutical Sciences 17, no. 2 (2021): 123–30. https://doi.org/10.5281/zenodo.5763090.

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Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. The development of enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in the mouth are very promising for the delivery of high molecular weight protein and peptide. Good mouth feel property of MDDS helps to change the basic view of medication as “bitter pill”, particularly for pediatric patients. To prepare mouth dissolving tablet using SSG & CCM by using Antihyper

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