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Dissertations / Theses on the topic 'Superoxise dismutase'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Dufernez, Fabienne. "Les superoxyde dismutases des protistes : caractérisation et origine phylogénétique." Lille 2, 2005. http://www.theses.fr/2005LIL2S030.

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Les organismes aérobies ont développé des mécanismes pour se protéger des attaques des espèces activées de l'oxygène produites lors du métabolisme cellulaire. La superoxyde dismutase (SOD) est une métalloenzyme du système de défense anti-oxydant. Elle catalyse la dismutation de l'anion superoxyde en peroxyde d'hydrogène. Les SOD se divisent en 2 grandes familles qui diffèrent fondamentalement d'un point de vue structural : les SOD qui utilisent simultanément le cuivre et le zinc comme métaux cofacteurs (Cu/Zn-SOD) et les SOD utilisant soit le fer (FeSOD) soit le manganèse (MnSOD) comme métal c
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2

Vinatier, Virginie. "Exploration de la voie péroxynitrite : nouveaux donneurs de NO, étude des superoxyde dimutases à fer et application à la conception d’inhibiteurs." Toulouse 3, 2007. http://www.theses.fr/2007TOU30008.

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Ce travail aborde divers aspects de la chimie du peroxynitrite et de ses précurseurs , le superoxyde et le monoxyde d’azote. Plusieurs donneurs de NO dérivés du SIN-1 ont été synthétisés et étudiés dans le but de diminuer la quantité de péroxynitrite formé pendant la décomposition et d’augmenter la biodisponibilité du NO. Les superoxyde dismutases à fer, enzymes protégeant les protozoaires du stress oxydant, des parasites Plasmodium falciparum, Trypanosoma cruzi et Trypanosoma brucei ont été surexprimées et caractérisées afin de découvrir de nouveaux composés antiparasitaires. La structure de
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3

Poinso, Alix. "Recherche d'inhibiteurs de la superoxyde dismutase à partir de substances naturelles." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30378/document.

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Le but de ce travail de thèse était de rechercher de nouvelles molécules inhibitrices de la SOD dans des extraits de substances naturelles. Cette enzyme majeure du stress oxydant étant impliquée dans de nombreux mécanismes de défense des cellules cancéreuses contre l'apoptose représente une voie thérapeutique d'avenir. Nous en avons recherché dans les champignons endophytes de plantes péruviennes, ces micro-organismes produisant de nombreux métabolites de défense des plantes hôtes. Ce travail de thèse a d'abord porté sur l'isolement, la culture, l'identification, l'extraction et la caractérisa
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4

Olofsson, Eva. "Superoxide dismutase 1 and cataract." Doctoral thesis, Umeå : Umeå universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21032.

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5

Kolahi-Ahari, Ali. "A study of superoxide dismutase activity and superoxide production in kiwifruit." Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/1343.

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The activity of superoxide dismutase (SOD) was determined in three kiwifruit (Actinidia) species including A. deliciosa, A. chinensis, and A. arguta. Among the species tested, the highest SOD activity was found in crude extracts prepared from fruit tissues of A. deliciosa. The highest enzyme activity was localized in seed, followed by locules, core and outer pericarp (OP). SOD activity in crude extract of whole fruit remained stable for at least one month when stored at -20℃. The effect of synthetic protease inhibitors (PI) on SOD activity was investigated. Supplementing crude kiwifruit extrac
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6

Sinaceur, Jamal Eddine. "Importance des dérivés réduits de l'oxygène dans l'intoxication alcoolique chez le rat : rôle de la desferrioxamine /." Paris : la Documentation française, 1987. http://catalogue.bnf.fr/ark:/12148/cb34926442c.

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7

Parker, Michael William. "Structural studies on manganese superoxide dismutase." Thesis, University of Oxford, 1985. https://ora.ox.ac.uk/objects/uuid:b8fff51f-1e2f-41b1-baff-4e95b499f0de.

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Superoxide dismutases are widely distributed enzymes which catalyse the dismutation of superoxide radicals to dioxygen and hydrogen peroxide and are considered to be an important agent of an organism's defence against oxygen toxicity. The crystallization and low resolution structure determination of manganese superoxide dismutase (E.G. 1.15.1.1) from Bacillus stearothermophiluB is described. The enzyme crystallized in space group P2<sub>1</sub>2<sub>1</sub>2 with two monomers per asymmetric unit and cell dimensions of ̲a=72.2Å, ̲b=111.1Å and ̲c=51.1Å. The crystals diffracted to beyond 2Ã
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8

Barkley, Katherine Byer. "Characterization of superoxide dismutase from Actinomyces." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53905.

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The anaerobes Actinomyces naeslundii, A. odontolyticus and Actinomyces strain ii E1S.25D produce a Mn-containing superoxide dismutase (MnSOD). Actinomyces, once classified as yeast based on their morphology, are saprophytic organisms found among the normal flora of the mouth but can act as endogenous pathogens resulting in gingivitis and actinomycosis. The ability of Actinomyces to scavenge superoxide may increase survival of the cell from the O₂⁻-dependent killing by polymorphonuclear leukocytes and also enable the organism to be transported through an oxygenated environment from one site to
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9

Meissner, Felix. "Superoxide dismutase 1 regulates caspase-1." Berlin mbv, 2008. http://d-nb.info/992999286/04.

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10

Jonsson, P. Andreas. "Superoxide dismutase 1 and amyotrophic lateral sclerosis." Doctoral thesis, Umeå : Medical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-611.

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11

Enayat, Zinat Ellaheh. "Superoxide dismutase mutations and amyotrophic lateral sclerosis." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400500.

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12

Blackney, Michael James. "Characterising the Drosophila extracellular superoxide Dismutase gene." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/179761/.

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The indiscriminate action of reactive oxygen species (ROS), if left unregulated, has long been considered contributory to a range of disease processes within the animal kingdom and is also a factor associated with ageing. Consequently modifying the molecular mechanisms that regulate ROS levels may prove therapeutic and could also positively affect longevity. One of the key components of this machinery is the superoxide dismutase (SOD) family of enzymes which regulate ROS levels by scavenging the ROS superoxide. Mammals have three distinct SOD enzymes each responsible for managing superoxide le
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13

Matemadombo, Fungisai. "Metallophthalocyanines as electrocatalysts and superoxide dismutase mimics." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1004985.

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Syntheses, spectral, electrochemical, and spectroelectrochemical studies of iron, cobalt, and manganese phthalocyanines are reported. The novel coordination of cobalt tetracarboxy metallophthalocyanine to an electrode premodified with aryl radicals and its use in the detection of thiocyanate are reported. This work describes the catalytic activity of cobalt phthalocyanine (CoPc) derivatives adsorbed onto glassy carbon electrodes for the electrocatalytical detection of nitrite, Lcysteine, and melatonin. The modified electrodes efficiently detected nitrite. The CoPc derivative modified electrode
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14

Macedo, Thais Rodrigues. "Avaliação das concentrações de superóxido dismutase e da fragilidade osmótica eritrocitária em cães com linfoma multicêntrico com e sem anemia." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-09022011-162444/.

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Linfomas são as neoplasias hematopoiéticas mais comumente relatadas em cães, podendo ocorrer em qualquer idade. A etiologia ainda é desconhecida, porém se aceita que seja multifatorial. São classificadas de acordo com sua localização anatômica, estadio clínico da Organização Mundial de Saúde (OMS), critérios cito-histológicos e imunofenotípicos. A anemia é a anormalidade hematológica mais observada em pacientes com câncer e manifesta-se em cerca dois terços dos cães com linfoma. Os radicais livres de oxigênio produzidos pelas células tumorais aumentam o estresse oxidativo, sendo este demonstra
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15

Yéra, Hélène. "Etude des superoxydes dismutases à fer (FeSOD1) des Apicomplexa Plasmodium falciparum et Toxoplasma gondii." Lille 2, 2004. http://www.theses.fr/2005LIL2S046.

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Au cours de leur développement chez l’homme, Plasmodium et Toxoplasma subissent un choc oxydant qui peut entraîner un effet létal. Pour se défendre, ils possèdent un système antioxydant, constitué essentiellement d’enzymes telle que la superoxyde dismutase (SOD). Contrairement aux autres eucaryotes qui possèdent deux SOD, une SOD à manganèse mitochondriale et une SOD à cuivre-zinc cytoplasmique, de nombreux protistes possèdent une ou plusieurs SOD à fer (FeSOD). Cette spécificité permet de considérer les FeSOD des protistes comme une cible thérapeutique potentielle. Il apparaît donc important
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16

Sornosa-Ten, Alejandra. "Complexes biomimétiques de la superoxyde dismutase." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13127.

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17

Lewis, Elizabeth A. "Functional models of manganese superoxide dismutases." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247034.

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18

Carillon, Julie. "Effets d’un concentré de melon, particulièrement riche en superoxyde dismutase, sur un modèle d’obésité nutritionnellement induite : hypothèses de mécanismes d’action." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20029/document.

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Les effets d'un concentré de melon, SODB®, particulièrement riche en SOD, ont été étudiés en mode curatif sur un modèle animal d'obésité nutritionnellement induite. La question du mécanisme d'action de ce concentré de melon a également été posée dans ce travail.Dans la première partie, des tests in vitro ont permis d'évaluer et de mieux caractériser le pouvoir antioxydant de SODB®. Il a également été montré, grâce à une étude sur rats sains, que SODB® n'était pas toxique aux doses utilisées.Dans une deuxième partie, des effets bénéfiques de SODB® sur le foie et le tissu adipeux d'animaux obèse
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19

Zetterström, Per. "Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis." Doctoral thesis, Umeå universitet, Klinisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43898.

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Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is always fatal, usually through respiratory failure when the disease reaches muscles needed for breathing. Most cases are sporadic, but approximately 5–10% are familial. The first gene to be linked to familial ALS encodes the antioxidant enzyme superoxide dismutase-1 (SOD1). Today, more than 160 different mutations in SOD1 have been found in ALS patients.  The mutant SOD1 proteins cause ALS by gain of a toxic property that should be common to al
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20

Quebec, Elizabeth Ann Hayes. "Crosslinked hemoglobin-superoxide dismutase-catalase and methemoglobin formation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29863.pdf.

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21

Regan, Elizabeth Anne. "Extracellular superoxide dismutase and oxidant stress in osteoarthritis /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Clinical Science) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 107-128). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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22

Wong, Kwan-yeung. "Roles of manganese superoxide dismutase in ovarian cancer." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39364689.

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23

Wong, Kwan-yeung, and 黃君揚. "Roles of manganese superoxide dismutase in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39364689.

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24

Temperton, Nigel James. "Functional studies on superoxide dismutase in Trypanosoma cruzi." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391814.

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25

Chen, Ying. "In vivo metal substitution in bacteroides superoxide dismutase." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44628.

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<p>The effect of various growth conditions on the type of superoxide dismutase (SGD) formed anaerobically in three Bacteriodes species was studied. B. fragilis, B. distasonis, and B. thetaiotaomicron were grown in ironâ restricted media with or without manganese supplementation. Iron availability was decreased by treatment of the media with chelex-100, a metal-chelating resin, and addition of desferrioxamine mesylate (desferal, Ciba-Geigy), an iron chelator. Mn-containing (MnSOD) and Fe-containing superoxide dismutase (EeSOD) activities in cell extracts were differentiated by inhibition with
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26

Mazura, Sergiy. "Effect of active pharmaceutical ingredients on superoxide dismutase." Thesis, Київський національний університет технологій та дизайну, 2019. https://er.knutd.edu.ua/handle/123456789/13082.

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27

Jadot, Guy. "Applications cliniques des superoxyde-dismutases." Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX21901.

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28

Bouvet, Jean. "Superoxide dismutase mimics : an integrated approach from chemical design to bioactivity in cells." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS583.pdf.

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Les superoxydes dismutases (SODs) sont des métalloenzymes, présentent dans l’ensemble du règne vivant, jouant un rôle crucial dans les défenses antioxydantes. En effet, elles régulent la concentration de l’anion superoxyde qui est un dérivé réactif de l’oxygène et un sous-produit naturel du métabolisme de celui-ci. Dans certaines maladies, comme les maladies inflammatoires chroniques de l’intestin, il a été montré une déficience des défenses antioxydantes et en particulier des SODs. En conséquence, une augmentation des espèces réactives de l’oxygène est observée (stress oxydant) qui serait imp
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29

Amar-Aguilar, Corinne. "Radicaux libres, superoxyde dismutase et maladies neurodégénératives." Montpellier 1, 1996. http://www.theses.fr/1996MON11078.

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30

Vincent, Amandine. "Étude de complexes mimes de superoxyde dismutases : de la conception de nouveaux composés par chimie combinatoire jusqu’à l’exploration des voies d’administration sur modèle murin." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEE049.

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Le travail de cette thèse porte sur la recherche de nouveaux mimes de superoxyde dismutase (SOD) à base de peptide grâce à une approche par chimie combinatoire. Parallèlement, les voies d’administration du mime Mn1 à des souris ont également été explorées. En effet, le complexe de manganèse II Mn1 a montré des effets anti-inflammatoires intéressants à trois échelles : in vitro, in cellula et sur un modèle souris de colite induite par du DNBS. L’activité du complexe est comparable à celle des meilleurs mimes de SOD décrits dans la littérature sur le modèle cellulaire macrophage et présente l’ef
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31

Peugnet, Victoriane. "Modifications post-traductionnelles de la protéine superoxyde dismutase 2 dans le coeur." Thesis, Lille, 2021. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2021/2021LILUS010.pdf.

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De nos jours, les pathologies cardiovasculaires représentent un enjeu de santé publique majeur dans les pays développés. Particulièrement, le remodelage ventriculaire gauche touche 30% des patients suite à un infarctus du myocarde et peut mener à terme à une insuffisance cardiaque. Le remodelage et l’insuffisance cardiaque sont associés au développement d’un stress oxydant, participant aux modifications structurales et fonctionnelles du coeur. L’objectif de ma thèse consistait en l’étude des modifications post-traductionnelles de la protéine anti-oxydante mitochondriale superoxyde dismutase 2
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32

Moon, Bok Hee. "A study of the activity and characteristics of superoxide dismutase in the male reproductive parts of Petunia : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Plant Biotechnology in the School of Biological Sciences, University of Canterbury /." Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/1326.

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In the stamen (male reproductive tissue) of petunia 'Hurrah' flowers, the occurrence of SOD (superoxide dismutase) provided an effective anti-oxidative mechanism against superoxide production. Superoxide production and SOD activities at five developmental stages showed a positive correlation. The highest superoxide production and SOD activity in different parts of the stamen (anther, filament and pollen) were at stages with high metabolic activity: (i) during growing buds (in anthers and filaments) (ii) when flowers with predehiscent anthers were fully open (in pollen). In all parts of the sta
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33

Cheung, Suet-ting, and 張雪婷. "Effects of superoxide dismutase 1 on frontal cortical neurons." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42924650.

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Cheung, Suet-ting. "Effects of superoxide dismutase 1 on frontal cortical neurons." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42924650.

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35

Samai, Mohamed. "Novel superoxide dismutase mimetics for protection against paraquat nephrotoxicity." Thesis, University of Brighton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485754.

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Paraquat (PO), a broad-spectrum herbicide, is primarily eliminated from the body unchanged via the kidneys. Unfortunately, it is nephrotoxic; and the PO-induced nephrotoxicity involves severe renal damage caused by reactive oxygen species (ROS), specifically by increasing superoxide anion (0/-) generation in the kidney. While proven to be of benefit in animal models of organ injury involving O2.-, superoxide dismutase (SOD) and superoxide dismutase mimetics (SOOm) can suffer problems regarding their bioavailability and toxicity. Since ROS has been incriminated in the pathogenesis of several di
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MacKenzie, Andrew. "Protection of vascular nitric oxide by superoxide dismutase mimetics." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266683.

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Münch, Christian. "Initiation and propagation of mutant superoxide dismutase 1 misfolding." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609791.

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38

Ma, Huaibo. "Modeling the Structure and Mechanism of Nickel Superoxide Dismutase." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1303327993.

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39

Durazo, Armando. "Hydrogen/deuterium exchange studies on copper-zinc superoxide dismutase." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1495960591&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Trist, Benjamin. "Superoxide dismutase 1 in the aetiology of Parkinson’s disease." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20579.

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Parkinson’s disease is the most common neurodegenerative movement disorder worldwide, and is the fastest growing neurological disease ahead of Alzheimer’s disease. Characteristic motor dysfunction results from the selective death of dopamine neurons in the substantia nigra pars compacta, however the aetiology of this neuron loss remains unknown. As such, current treatments help to alleviate Parkinsonian motor symptoms, but none are able to slow or halt the rate of dopaminergic neuron loss. A greater understanding of the molecular pathways leading to dopamine neuron death will accelerate the de
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Corvo, Maria Luisa Teixeira de Azevedo Rodrigues. "Liposomes as delivery system for superoxide dismutase in experimental arthritis = Liposomen als dragersystemen voor superoxide dismutase in experimental artritis : Lipossomas come sistema terapêutico para superóxido dismutase na artrite experimental /." [S.l. : s.n.], 1998. http://www.gbv.de/dms/bs/toc/300314604.pdf.

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Tew, D. G. "Some reactions of spin traps." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355814.

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43

Bendall, Jennifer Kate. "Physiology and pathophysiology of cardiac NADPH oxidase." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289766.

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Rengifo, Emérita Mendoza. "Exploring the selectivity of metal ions in the active site of the enzyme superoxide dismutase (SOD) using site-directed mutagenesis." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05012017-114055/.

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Iron/Manganese superoxide dismutases (Fe/Mn-SODs) are metalloenzymes with highly conserved protein folds, active sites, and dimer interfaces. They protect cells against oxidative stress by catalyzing the conversion of the cytotoxic free radical superoxide to molecular oxygen and hydrogen peroxide. The majority are highly specific for the type of metal (iron or manganese) present within the active site. However, there are many key aspects of metal specificity and catalytic activity that lack a structural explanation. Computational analyses suggested that several residues are important for fine-
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45

Becuwe, Philippe. "Les superoxyde dismutases de plasmodium et babesia : contribution à leur caractérisation." Lille 1, 1994. http://www.theses.fr/1994LIL10074.

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Plasmodium, agent du paludisme, est repute sensible au choc oxydant et son systeme de defense n'est pas encore bien connu. Dans ce travail, nous avons caracterise une sod endogene chez plasmodium et chez babesia (agent de la piroplasmose). Chez p. Falciparum (pathogene pour l'homme) et chez 4 souches murines, l'activite sod endogene existe sous 2 isoformes majeures et represente 20-30% de l'activite totale. Les 70-80% restants correspondent a de l'activite sod de l'hematie, internalisee par le parasite. Chez b. Divergens et b. Hylomysci, l'activite sod endogene represente la quasi-totalite de
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46

Gratepanche, Sylvie. "La superoxyde dismutase à fer de Plasmodium falciparum." Lille 1, 1997. http://www.theses.fr/1997LIL10227.

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Au cours de son developpement dans l'hematie, plasmodium falciparum est soumis a un choc oxydant qui peut etre lethal pour le parasite. Celui-ci doit donc mettre en place un systeme de defense dirige contre les especes activees de l'oxygene. En effet, une sod qui constitue la premiere enzyme impliquee dans le systeme enzymatique antioxydant a ete caracterisee chez ce parasite (becuwe et coll. , 1996). La nature fer dependante probable de cette enzyme qui se distingue de celles de l'hote (cu/zn et mn dependantes) laisse supposer qu'elle puisse etre un bon candidat pour un ciblage medicamenteux.
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Bond, Christopher J. "Regulation, structure and folding of enzymes /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9247.

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48

Bergemalm, Daniel. "Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31116.

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49

Greenleaf, William Bruce. "Proton transfer in catalysis by iron and manganese superoxide dismutase." [Gainesville, Fla.] : University of Florida, 2004. http://wwwlib.umi.com/cr/ufl/fullcit?p3136943.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 94 pages. Includes Vita. Includes bibliographical references.
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Pramatarova, Albéna. "Role of CuZn superoxide dismutase in familial amyotrophic lateral sclerosis." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36684.

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Abstract:
Amyotrophic lateral sclerosis (ALS) is a late onset neuro-degenerative disorder characterized by highly selective death of large motor neurons in the cerebral cortex and spinal cord. A proportion of the familial cases (FALS) with autosomal dominant transmission was linked to chromosome 21q and the defective gene was shown to be the Cu/Zn superoxide dismutase gene (SOD1). SOD1 is a ubiquitously expressed cytoplasmic metalloenzyme catalyzing the dismutation of the superoxide free radical into hydrogen peroxide and molecular oxygen. We have screened our FALS patients for mutations in the SOD1 gen
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