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Journal articles on the topic 'Superporous hydrogel'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pawar, Darshana, Darshan Jamindar, Nadeem A. Farooqui, and Nimita Manocha. "Superporous Hydrogel: A Novel Approach for Safe Gastroretentive Drug Delivery System." Journal of Drug Delivery and Therapeutics 14, no. 4 (2024): 123–29. http://dx.doi.org/10.22270/jddt.v14i4.6458.

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Superporous hydrogel are developed initially as novel drug delivery system to retain dosage form in upper gastrointestinal tract, and absorbs drug in gastric medium. The generation-based classification of superporous hydrogel is covered in this review. The hydrophilic polymer networks formed by the molecular entanglements which absorb water up to thousands of times to their dry weight. These systems swells quickly and resist in an extremely acidic condition in stomach. This hydrogel is instantly swell through capillary force which is driven by absorption of water through an open porous structu

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2

CHEN, JUN, and KINAM PARK. "SUPERPOROUS HYDROGELS: FAST RESPONSIVE HYDROGEL SYSTEMS." Journal of Macromolecular Science, Part A 36, no. 7-8 (1999): 917–30. http://dx.doi.org/10.1080/10601329908951189.

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3

CHEN, JUN, and KINAM PARK. "SUPERPOROUS HYDROGELS: FAST RESPONSIVE HYDROGEL SYSTEMS." Journal of Macromolecular Science, Part A- Pure and Applied Chemistry 36, no. 7&8 (1999): 917–30. http://dx.doi.org/10.1081/ma-100101572.

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4

Srikala, S. Vinaya, Nagam Santhi Priya, and Rama Rao Nadendla. "Formulation, Characterization and Antihelminthic Activity Testing of Nitazoxanide Superporous Hydrogel Tablets." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 26–36. http://dx.doi.org/10.22270/jddt.v10i3-s.4130.

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In the pharmaceutical field controlled release products have the ability to maintain desired medicament concentration or a longer period of time. Certain drugs are relatively insoluble in water and have high dose requirements that render unsuitable formulation difficulties in sustained release formulations. Nitazoxanide which is a high dose water insoluble antiprotozoal drug was formulated with the aim. To modulate gastro-retentive dosage form based on the superporous hydrogel composites. Foaming technique was used in the preparation of SPH composites. The superporous hydrogels were extremely

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5

Kumari, Khushi* Bhattachrya Vijeta. "Development Of Superporous Hydrogel in Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2299–309. https://doi.org/10.5281/zenodo.15410891.

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Recently superporous hydrogel (SPHs)have been developed as a new kind of novel drug delivery system because of their unique structure and improved properties. suoerporous hydro-gel consist of highly interlinked, macropores network, facilitating the fast swelling and uptake of significant quantities of of water to create suitable for application product.due to rapid swelling behaviour along with high drug loading capacity and controlled release nature, SPHs are a potential candidate for oral, transdermal and local drug delivery system. Superporous hydrogels (SPHs) are a class of hydrophilic sub

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6

Muhammad, Gulzar, Muhammad Ajaz Hussain, Muhammad Umer Ashraf, Muhammad Tahir Haseeb, Syed Zajif Hussain, and Irshad Hussain. "Polysaccharide based superabsorbent hydrogel from Mimosa pudica: swelling–deswelling and drug release." RSC Advances 6, no. 28 (2016): 23310–17. http://dx.doi.org/10.1039/c5ra23088h.

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7

Bhalla, Shikha, and Manju Nagpal. "Comparison of Various Generations of Superporous Hydrogels Based on Chitosan-Acrylamide and In Vitro Drug Release." ISRN Pharmaceutics 2013 (July 29, 2013): 1–8. http://dx.doi.org/10.1155/2013/624841.

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The aim of the current research work was to prepare and evaluate different generations of superporous hydrogels (SPH) of acrylamide and chitosan using gas blowing technique and evaluate them for swelling, mechanical properties, FTIR, SEM, XRD, and in vitro drug release. The ingredients used were acrylamide, N,N′-methylene bisacrylamide, chitosan, Pluronic F127, ammonium per sulfate-N,N,N′,N′-tetramethylenediamine, and sodium bicarbonate. All ingredients were mixed sequentially with thorough stirring. The effect of different drying conditions on properties of SPH was also evaluated. Ethanol tre

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8

Khatoon, Maria, Arshad Ali, Muhammad Ajaz Hussain, et al. "A superporous and pH-sensitive hydrogel from Salvia hispanica (chia) seeds: stimuli responsiveness, on–off switching, and pharmaceutical applications." RSC Advances 14, no. 38 (2024): 27764–76. http://dx.doi.org/10.1039/d4ra04770b.

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9

Bahsis, Lahoucine, El-Houssaine Ablouh, Hafid Anane, Moha Taourirte, Miguel Julve, and Salah-Eddine Stiriba. "Cu(ii)-alginate-based superporous hydrogel catalyst for click chemistry azide–alkyne cycloaddition type reactions in water." RSC Advances 10, no. 54 (2020): 32821–32. http://dx.doi.org/10.1039/d0ra06410f.

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10

Safa Mohammed Nser, Athmar Dhahir Habeeb Al-Shohani, and Alaa Abuawad. "Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 4 (2023): 355–66. http://dx.doi.org/10.32947/ajps.v23i4.1091.

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Superporous hydrogel composite is widely utilized and investigated as a gastro retentive drug delivery system. Materials used in Superporous hydrogel formulation have a profound effect on its properties’, N-methylene bisacrylamide is the crosslinker of choice for the preparation of SPH. The purpose of this study is to determine if using a new high molecular weight crosslinker such as polyethylene glycol diacrylate will affect the physical characteristics of SPH and drug release behavior. For the preparation of super porous hydrogel polyvinyl alcohol, acrylamide, polyethylene glycol diacr

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11

Ali, Arshad, Muhammad Tahir Haseeb, Muhammad Ajaz Hussain, et al. "A pH responsive and superporous biocomposite hydrogel of Salvia spinosa polysaccharide-co-methacrylic acid for intelligent drug delivery." RSC Advances 13, no. 8 (2023): 4932–48. http://dx.doi.org/10.1039/d2ra05240g.

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Mucilage from seeds of Salvia spinosa (SSH; polymer) and methacrylic acid (MAA; monomer) are copolymerized to obtain a pH responsive superporous hydrogel for the controlled delivery of venlafaxine HCl.

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12

Zasońska, Beata A., Antonín Brož, Miroslav Šlouf, et al. "Magnetic Superporous Poly(2-hydroxyethyl methacrylate) Hydrogel Scaffolds for Bone Tissue Engineering." Polymers 13, no. 11 (2021): 1871. http://dx.doi.org/10.3390/polym13111871.

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Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy c

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13

Chen, Jun, William E. Blevins, Haesun Park, and Kinam Park. "Gastric retention properties of superporous hydrogel composites." Journal of Controlled Release 64, no. 1-3 (2000): 39–51. http://dx.doi.org/10.1016/s0168-3659(99)00139-x.

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14

Chen, Jun, and Kinam Park. "Synthesis and characterization of superporous hydrogel composites." Journal of Controlled Release 65, no. 1-2 (2000): 73–82. http://dx.doi.org/10.1016/s0168-3659(99)00238-2.

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15

Soumya, B., Swarupa Arvapalli, J. V. C. Sharma, and Potnuri Nagaraju. "Design, Characterization and In-vitro Evaluation of Superporous Hydrogel Tablets of Nimodipine." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 300–309. http://dx.doi.org/10.22270/jddt.v9i3.2659.

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The present work was aimed to formulate Superporous Hydrogel tablets of Nimodipine using an effervescent approach for gastro retentive drug delivery system to improve its bioavailability by using different rate retarding polymers like plantago ovata, tamarind gum and carbopol, along with suitable excipients. All the formulations were prepared by direct compressionmethod. The prepared tablets of all the formulations were evaluated for physical characteristics, in‐vitro drug release, hardness and friability. Optimized formulation F8 containing 0.3% of plantago ovata and carbopol each was conside

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16

Gils, Palapparambil Sunny, Debajyoti Ray, and Prafulla Kumar Sahoo. "Characteristics of xanthan gum-based biodegradable superporous hydrogel." International Journal of Biological Macromolecules 45, no. 4 (2009): 364–71. http://dx.doi.org/10.1016/j.ijbiomac.2009.07.007.

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17

Abdel Halim, S. A., S.A.Yehia, and M. A. El-Nabarawi. "Chromium picolinate loaded superporous hydrogel and superporous hydrogel composite as a controlled release device: in vitro and in vivo evaluation." Journal of Drug Delivery Science and Technology 24, no. 4 (2014): 326–37. http://dx.doi.org/10.1016/s1773-2247(14)50070-6.

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18

Smith, Shane Ida. "Superporous Intelligent Hydrogels for Environmentally Adaptive Building Skins." MRS Advances 2, no. 46 (2017): 2481–88. http://dx.doi.org/10.1557/adv.2017.429.

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ABSTRACTThis work explores responsive hydrophilic polymers for convergent functions of climate control with architectural material systems. In buildings, the transition across exterior and interior space occurs through the envelope, which is an enclosure system that mediates heat, light, air and moisture transfer functions. Conventional building envelopes are typically constructed to form a barrier that insulates and hermetically separates outdoor and indoor conditions. The dynamic environmental responses of superporous intelligent hydrogels are shown to be beneficial at the interior layer of

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19

Jhawat, Vikas, Monika Gulia, Balaji Maddiboyina, Rohit Dutt, and Sumeet Gupta. "Fate and Applications of Superporous Hydrogel Systems: A Review." Current Nanomedicine 10, no. 4 (2020): 326–41. http://dx.doi.org/10.2174/2468187310999200819201555.

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Hydrogels are a class of biomaterial that can “take in” large quantities of aqueous media and swells many times larger than its original size without dissolving in the media. SPHs are a new generation of hydrogels containing a 3D network of cross-linked polymers having pore size more than 100 μm as compared to 10 nm to 10 μm pores of conventional gels. These are more complex in nature than conventional hydrogels and prepared by using a suitable blend of monomers and different additives. SPHs have been extensively employed in sustained and control drug delivery systems along with many recent bi

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20

Chavda, HV, CN Patel, and HD Karen. "Preparation and characterization of chitosan-based superporous hydrogel composite." Journal of Young Pharmacists 1, no. 3 (2009): 199. http://dx.doi.org/10.4103/0975-1483.57064.

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21

Chavda, HV, and CN Patel. "Effect of crosslinker concentration on characteristics of superporous hydrogel." International Journal of Pharmaceutical Investigation 1, no. 1 (2011): 17. http://dx.doi.org/10.4103/2230-973x.76724.

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22

Omidian, Hossein, Jose G. Rocca, and Kinam Park. "Elastic, Superporous Hydrogel Hybrids of Polyacrylamide and Sodium Alginate." Macromolecular Bioscience 6, no. 9 (2006): 703–10. http://dx.doi.org/10.1002/mabi.200600062.

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23

Svozilová, Hana, Zdeněk Plichta, Vladimír Proks, et al. "RGDS-Modified Superporous Poly(2-Hydroxyethyl Methacrylate)-Based Scaffolds as 3D In Vitro Leukemia Model." International Journal of Molecular Sciences 22, no. 5 (2021): 2376. http://dx.doi.org/10.3390/ijms22052376.

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Superporous poly(2-hydroxyethyl methacrylate-co-2-aminoethyl methacrylate) (P(HEMA-AEMA)) hydrogel scaffolds are designed for in vitro 3D culturing of leukemic B cells. Hydrogel porosity, which influences cell functions and growth, is introduced by adding ammonium oxalate needle-like crystals in the polymerization mixture. To improve cell vitality, cell-adhesive Arg-Gly-Asp-Ser (RGDS) peptide is immobilized on the N-(γ-maleimidobutyryloxy)succinimide-activated P(HEMA-AEMA) hydrogels via reaction of SH with maleimide groups. This modification is especially suitable for the survival of primary c

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24

Chavda, Hitesh, Gordhan Chavada, Jaimeen Patel, Kiran Rangpadiya, and Chhagan Patel. "Topical Vaginal Drug Delivery System Based on Superporous Hydrogel Hybrids." Protein & Peptide Letters 21, no. 11 (2014): 1176–84. http://dx.doi.org/10.2174/0929866521666140807101402.

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25

Chavda, HiteshV, IshanP Modhia, RupalD Patel, and ChhaganN Patel. "Preparation and characterization of superporous hydrogel based on different polymers." International Journal of Pharmaceutical Investigation 2, no. 3 (2012): 134. http://dx.doi.org/10.4103/2230-973x.104396.

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26

Lee, Gye Won, So Jeong Boo, Soo Hwan Lee, and Young Ho Cho. "Development of Superporous Interpenetrating Polymer Network Hydrogel Containing Sapogrelate Hydrochloride." KSBB Journal 35, no. 2 (2020): 169–77. http://dx.doi.org/10.7841/ksbbj.2020.35.2.169.

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27

Omidian, Hossein, David Mastropietro, and Umadevi Kandalam. "Swelling, strength, and biocompatibility of acrylate-based superporous hydrogel hybrids." Journal of Bioactive and Compatible Polymers 29, no. 1 (2014): 66–80. http://dx.doi.org/10.1177/0883911513508496.

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28

Yang Nilsson, Ting, and Markus Andersson Trojer. "A solution blown superporous nonwoven hydrogel based on hydroxypropyl cellulose." Soft Matter 16, no. 29 (2020): 6850–61. http://dx.doi.org/10.1039/d0sm00724b.

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29

Balamuralidhara, V., T. M. Pramod Kumar, N. Vishal Gupta, Anil Getyala, and H. V. Gangadharappa. "Development of a Novel Biodegradable Superporous Hydrogel for Gastroretentive Application." International Journal of Polymeric Materials 62, no. 10 (2013): 524–32. http://dx.doi.org/10.1080/00914037.2012.735297.

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30

Yin, Lichen, Xin Zhao, Liming Cui, et al. "Cytotoxicity and genotoxicity of superporous hydrogel containing interpenetrating polymer networks." Food and Chemical Toxicology 47, no. 6 (2009): 1139–45. http://dx.doi.org/10.1016/j.fct.2009.01.043.

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31

Tolga Demirtaş, T., Ayşe Gönen Karakeçili, and Menemşe Gümüşderelioğlu. "Hydroxyapatite containing superporous hydrogel composites: synthesis and in-vitro characterization." Journal of Materials Science: Materials in Medicine 19, no. 2 (2007): 729–35. http://dx.doi.org/10.1007/s10856-007-3008-7.

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32

Tang, Cui, Lichen Yin, Jing Yu, Chunhua Yin, and Yuanying Pei. "Swelling behavior and biocompatibility of Carbopol-containing superporous hydrogel composites." Journal of Applied Polymer Science 104, no. 5 (2007): 2785–91. http://dx.doi.org/10.1002/app.25930.

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33

Jihad, Haider Mohammed, and Entidhar J. Al- Akkam. "Formulation and in-vitro Evaluation of Carvedilol Gastroretentive Capsule as (Superporous Hydrogel)." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 2 (2021): 196–207. http://dx.doi.org/10.31351/vol30iss2pp196-207.

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The preferred route of drug administration is the oral route, but drugs with narrow absorption window in the gastrointestinal tract are still challenging. The ability to extend and monitor the gastric emptying time is a valuable tool for processes remaining in the stomach longer than other traditional dosage forms. The purpose of this study was to formulate and evaluate gastroretentive superporous hydrogel (SPH) of carvedilol with view to improve its solubility and increase gastric residence time in order to get sustained release formulas via utilization of various kinds and concentratio

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34

Mittal, Hemant, Ali Al Alili, and Saeed M. Alhassan. "Adsorption isotherm and kinetics of water vapors on novel superporous hydrogel composites." Microporous and Mesoporous Materials 299 (June 2020): 110106. http://dx.doi.org/10.1016/j.micromeso.2020.110106.

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35

Beşkardeş, Işıl Gerçek, Tuğrul Tolga Demirtaş, Müge Dağlı Durukan, and Menemşe Gümüşderelioğlu. "Microwave-assisted fabrication of chitosan-hydroxyapatite superporous hydrogel composites as bone scaffolds." Journal of Tissue Engineering and Regenerative Medicine 9, no. 11 (2012): 1233–46. http://dx.doi.org/10.1002/term.1677.

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36

Lee, Yu-Ping, Hsin-Yu Liu, Po-Chun Lin, et al. "Facile fabrication of superporous and biocompatible hydrogel scaffolds for artificial corneal periphery." Colloids and Surfaces B: Biointerfaces 175 (March 2019): 26–35. http://dx.doi.org/10.1016/j.colsurfb.2018.11.013.

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37

Chavda, Hitesh, Ishan Modhia, Anant Mehta, Rupal Patel, and Chhagan Patel. "Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/563651.

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Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 32full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content,in vitrodrug release, and stability studies. To a

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38

Chavda, Hitesh, and Chhaganbhai Patel. "Chitosan superporous hydrogel composite-based floating drug delivery system: A newer formulation approach." Journal of Pharmacy And Bioallied Sciences 2, no. 2 (2010): 124. http://dx.doi.org/10.4103/0975-7406.67010.

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39

Goyal, Ashwani. "Superporous Hydrogel Composites of Acrylamide Using Starch-silicone Dioxide Coprecipitate as Composite Agent." British Journal of Pharmaceutical Research 4, no. 3 (2014): 338–51. http://dx.doi.org/10.9734/bjpr/2014/6277.

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40

Sarkar, Niladri, Gyanaranjan Sahoo, and Sarat K. Swain. "Reduced graphene oxide decorated superporous polyacrylamide based interpenetrating network hydrogel as dye adsorbent." Materials Chemistry and Physics 250 (August 2020): 123022. http://dx.doi.org/10.1016/j.matchemphys.2020.123022.

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41

Chavda, HiteshV, RupalD Patel, IshanP Modhia, and ChhaganN Patel. "Role of superporous hydrogel particles as a superdisintegrant in fast disintegrating tablet of Glipizide." Chronicles of Young Scientists 5, no. 1 (2014): 11. http://dx.doi.org/10.4103/2229-5186.129329.

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42

Shi, Xiaoning, Wenbo Wang, and Aiqin Wang. "pH-responsive sodium alginate-based superporous hydrogel generated by an anionic surfactant micelle templating." Carbohydrate Polymers 94, no. 1 (2013): 449–55. http://dx.doi.org/10.1016/j.carbpol.2013.01.019.

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43

Souza, Jaqueline F., Gabriel P. Costa, Rafael Luque, Diego Alves, and André R. Fajardo. "Polysaccharide-based superporous hydrogel embedded with copper nanoparticles: a green and versatile catalyst for the synthesis of 1,2,3-triazoles." Catalysis Science & Technology 9, no. 1 (2019): 136–45. http://dx.doi.org/10.1039/c8cy01796d.

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44

DESU, Prasanna Kumar, Venkateswararao PASAM, and Vijay KOTRA. "Formulation and in vitro evaluation of superporous hydrogel based gastroretentive drug delivery system of vildagliptin." Journal of Research in Pharmacy 23, no. 5 (2019): 873–85. http://dx.doi.org/10.35333/jrp.2019.35.

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45

Dorkoosh, F. A., J. C. Verhoef, G. Borchard, M. Rafiee-Tehrani, J. H. M. Verheijden, and H. E. Junginger. "Intestinal absorption of human insulin in pigs using delivery systems based on superporous hydrogel polymers." International Journal of Pharmaceutics 247, no. 1-2 (2002): 47–55. http://dx.doi.org/10.1016/s0378-5173(02)00361-7.

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46

Goganian, Amir Mohammad, Hamed Hamishehkar, Nasser Arsalani, and Hanie Khaksar Khiabani. "Microwave-Promoted Synthesis of Smart Superporous Hydrogel for the Development of Gastroretentive Drug Delivery System." Advances in Polymer Technology 34, no. 2 (2014): n/a. http://dx.doi.org/10.1002/adv.21490.

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47

Islam, Mubinul, Hemant Mittal, Ali Al Alili, Saeed Alhassan, Vaneet Kumar, and Md Islam. "Activated carbon/superporous hydrogel composite-based polymer desiccants for capturing water vapor from humid air." Powder Technology 458 (May 2025): 121001. https://doi.org/10.1016/j.powtec.2025.121001.

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48

Lodhi, Bilal Ahmad, Muhammad Ajaz Hussain, Muhammad Sher, et al. "Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release." Advances in Polymer Technology 2019 (January 1, 2019): 1–11. http://dx.doi.org/10.1155/2019/9583516.

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swelling-deswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of B

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49

Mishra, Dinanath, Manju Nagpal, and ShailendraKumar Singh. "Synthesis characterization and in vitro drug release from acrylamide and sodium alginate based superporous hydrogel devices." International Journal of Pharmaceutical Investigation 3, no. 3 (2013): 131. http://dx.doi.org/10.4103/2230-973x.119215.

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50

Yin, Lichen, JieYing Ding, Likun Fei, et al. "Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles." International Journal of Pharmaceutics 350, no. 1-2 (2008): 220–29. http://dx.doi.org/10.1016/j.ijpharm.2007.08.051.

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