Relevant bibliographies by topics / Supported Liquid Membranes (SLM)

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Supported Liquid Membranes (SLM)'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Supported Liquid Membranes (SLM)"

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Yang, X. J., A. G. Fane, and S. MacNaughton. "Removal and recovery of heavy metals from wastewaters by supported liquid membranes." Water Science and Technology 43, no. 2 (January 1, 2001): 341–48. http://dx.doi.org/10.2166/wst.2001.0109.

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The removal and recovery of Cu, Cr and Zn from plating rinse wastewater using supported liquid membranes (SLM) are investigated. SLMs with specific organic extractants as the liquid membrane carriers in series are able to remove and concentrate heavy metals with very high purity, which is very promising for recycling of heavy metals in the electroplating industry. A technical comparison between the membrane process and the conventional chemical precipitation process was made.
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Reyes-Aguilera, J. A., M. P. Gonzalez, R. Navarro, T. I. Saucedo, and M. Avila-Rodriguez. "Supported liquid membranes (SLM) for recovery of bismuth from aqueous solutions." Journal of Membrane Science 310, no. 1-2 (March 5, 2008): 13–19. http://dx.doi.org/10.1016/j.memsci.2007.10.020.

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Huang, Du Shu, Yong Min, Li Hua Yao, Jin Yang, Ya Shun Chen, and Wei Liu. "Partition-Diffusion Model for Enantioseparation of Phenylalanine Using Hollow Fiber SLM." Advanced Materials Research 485 (February 2012): 44–47. http://dx.doi.org/10.4028/www.scientific.net/amr.485.44.

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This paper deals with the partittion-diffusion model of transport and enantioseparation of phenylalanine across hollow fiber supported liquid membranes. Observed partition coefficient between the feed phase and the membrane phase, the stripping phase and the membrane phase, mass transfer resistance of boundary layer in strip phase inside the hollow fibers, boundary layer in feed phase and the diffusion in the membrane phase are taken into account in the model equations.
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Ashraf, Mohammad Waqar, Nidal Abulibdeh, and Abdus Salam. "Selective Removal of Malachite Green Dye from Aqueous Solutions by Supported Liquid Membrane Technology." International Journal of Environmental Research and Public Health 16, no. 18 (September 19, 2019): 3484. http://dx.doi.org/10.3390/ijerph16183484.

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A lab-scale study on the application of supported liquid membranes (SLM) has been conducted for recovery and selective removal of Malachite Green dye from wastewater. Naturally occurring non-toxic vegetable oils have been used as membrane liquids. Polyvinylidene fluoride (PVDF) films have been used as supports for the liquid membrane. Various parameters affecting the dye permeation such as initial dye concentration, pH, stripping acid concentration, oil viscosity and membrane stability have been investigated. The highest flux value (1.65 × 10−5 mg/cm2/sec) was obtained with a sunflower oil supported membrane at pH 11 in the feed and 0.25 M HCl in the stripping solution. The membrane showed good stability under optimum conditions and maximum transport was achieved in 8 h of permeation time.
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Parhi, P. K. "Supported Liquid Membrane Principle and Its Practices: A Short Review." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/618236.

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The present paper on the supported liquid membrane (SLM) deals with the general principles and applications, followed by the uphill transportation characteristic of SLM. The liquid-liquid extraction with supported liquid membrane is one of the best alternate and promising technologies for the extraction of metal ions from solutions over other hydrometallurgical separation processes. The salient features of the supported liquid membrane (SLM) technique such as simultaneous extraction and stripping, low solvent inventory, process economy, high efficiency, less extractant consumption, and operating costs are discussed in detail. The supported liquid membrane of hollow fiber type provides high interfacial surface area for achieving maximum metal flux. Also the use of different organic extractants for SLM has been discussed.
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Drapała, A., P. Dzygiel, J. A. Jönsson, and P. Wieczorek. "Supported liquid membrane extraction of peptides." Acta Biochimica Polonica 48, no. 4 (December 31, 2001): 1113–16. http://dx.doi.org/10.18388/abp.2001_3874.

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The application of supported liquid membrane (SLM) extraction for the enrichment of short peptides is presented. The extraction efficiency is dependent on the pH of donor phase and salt concentration in acceptor phase. Moreover, the extraction efficiency is also influenced by the peptide amino-acid sequence and hydrophobicity.
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Naim, Mona M., Abeer A. Moneer, Mahmoud M. Elewa, and Ahmed A. El-Shafei. "Desalination using modified configuration of supported liquid membrane with enhancement of mass transfer of NaCl." Water Science and Technology 79, no. 1 (January 1, 2019): 175–87. http://dx.doi.org/10.2166/wst.2019.039.

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Abstract Supported liquid membranes (SLM) suffer from very slow mass transfer of the solute from the donor phase (DP) to the receptor phase (RP) through the liquid membrane (LM). In the present work, an attempt was made to accelerate the mass transfer in SLM by creating a modified configuration in which the DP and RP are made to flow either co- or counter-currently to each other. Variables, which could affect the removal of NaCl, were the volume ratio of DP to RP, type and quantity of sequestering agent (SA), presence of mobile carrier (MC), type of LM, and flow rate of DP and RP. The results showed that the higher the flow rate of DP and RP, the higher the mass transfer of NaCl. Quantity and type of SA and type of LM were prime important factors. Remarkably, the time required for transfer of NaCl from DP to RP was reduced from several hours in the case of stagnant SLM to several minutes in the present work. The mass transfer of NaCl was analysed based on kinetic laws of two consecutive irreversible first-order reactions. The values achieved establish the process is diffusion controlled, and the membrane entrance rate constants increase directly with initial concentration (Ci) and inversely with quantity of SA.
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Tayeb, Rafik, Claudia Fontas, Mahmoud Dhahbi, Sophie Tingry, and Patrick Seta. "Cd(II) transport across supported liquid membranes (SLM) and polymeric plasticized membranes (PPM) mediated by Lasalocid A." Separation and Purification Technology 42, no. 2 (March 2005): 189–93. http://dx.doi.org/10.1016/j.seppur.2004.07.006.

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Van de Voorde, I., L. Pinoy, and R. F. De Ketelaere. "Recovery of nickel ions by supported liquid membrane (SLM) extraction." Journal of Membrane Science 234, no. 1-2 (May 2004): 11–21. http://dx.doi.org/10.1016/j.memsci.2004.01.002.

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Vander Linden, J. "Selective recuperation of copper by supported liquid membrane (SLM) extraction." Journal of Membrane Science 139, no. 1 (February 4, 1998): 125–35. http://dx.doi.org/10.1016/s0376-7388(97)00252-4.

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Dissertations / Theses on the topic "Supported Liquid Membranes (SLM)"

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Van, Wyk Albertus Maritz. "The use of crosslinked polyethylene for the manufacturing of membranes / Albertus Maritz van Wyk." Thesis, Potchefstroom University for Christian Higher Education, 1999. http://hdl.handle.net/10394/9615.

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Increasing environmental awareness over the past decade as well as stringent environmental laws forced all factories to invest in water treatment processes for effluent treatment before discharge or re-use. Most of these effluent treatment processes utilize membranes as the physical. barrier for separation. The membranes used in water applications are expensive and alternative materials and production techniques will increase the viability of membrane separation processes. Experiments conducted on irradiated polyethylene showed that some of its properties were enhanced while others deteriorated. However, the enhanced properties make the polyethylene, in particular ultra-high molecular weight polyethylene, an ideal membrane material. The manufactured membranes were tested in extraction experiments, and satisfactory results were obtained. Permeation studies on the membranes compared favourably with similar studies done on commercially available membranes. An extraction rate of 1.08 g/(m2h) nickel was achieved. A preliminary cost evaluation showed that these membranes can be manufactured at a low cost (R13.45/m2). and can be applied as supported liquid membranes. Future research should focus on methods to decrease the brittleness and stiffness of the membranes.
Thesis (MIng)--PU for CHE, 1999
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Owens, Lesley Shantell. "Fabrication, Validation, and Performance Evaluation of a New Sampling System for the In-Situ Chemical Speciation of Chromium Ions in Groundwater Using Supported Liquid Membranes (SLMs)." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/49616.

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A sampler has been fabricated to facilitate the in-situ speciation of Cr. Teflon® was selected as the material for the samplers because of its inert chemical nature. The design of the sampler is based on the Supported Liquid Membrane (SLM) extraction technique, which utilizes charged organic carrier molecules loaded onto a polymeric (Teflon®) support membrane and the principles of electrostatics to selectively transport Cr ions through an ion-pairing mechanism. Cr ions in the feed solution that have an opposite charge from the carrier molecule form an ion-pair with the carrier and are transported through the membrane and deposited into a second aqueous phase referred to as the acceptor phase. A counter-ion from the acceptor phase is exchanged for the Cr ion to complete the extraction process. Since the acceptor phase is contained in a Teflon® bottle, the SLM sampler is capable of speciation and storage of Cr ions, which is a major advantage over current speciation techniques.

A food coloring test was used to check the samplers for leaks. A plastic barrier was used in place of the polymeric membrane and the acceptor phase bottle was filled with DI water. The sampler was submerged in a beaker containing food coloring and DI water. The bottle contents were checked for the presence of food coloring using UV-vis spectroscopy. The sampler was determined to be leak-free if the bottle did not contain food coloring. All systems prepared were validated upon the initial test and required no further manipulation to ensure structural soundness.

The SLM extraction technique involves two liquid-liquid extractions (LLEs). Before the samplers could be evaluated for their performance and stability in Cr speciation applications, liquid-liquid extraction studies were conducted on both systems (Cr (III) and Cr (VI)) to determine the optimal operating parameters (carrier concentration, decanol concentration, and acceptor phase concentration) of the SLM system. The selectivity of each system was also evaluated to validate proper SLM function.

The performance of the samplers was evaluated in a series of tank studies that focused on the uptake of Cr into the acceptor phase as well as the depletion of Cr ion from this phase. The goal of the performance studies was to determine the mechanical and chemical stability of the SLM samplers. As part of the validation process, selectivity studies and studies without the carrier molecule were conducted to ensure that the systems were functioning according to SLM theory. Tank studies that simulated natural sampling condition were also conducted.

The results of the tests conducted in the laboratory indicate that the SLM samplers are a stable, reliable, and viable method for Cr speciation. Future directions of this project will include the incorporation of the SLM sampler into the existing Multi-layer Sampler (MLS) technology as well as the analysis of the stability and performance of the incorporated systems in the ""in-situ speciation application.

Ph. D.
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Hansson, Helena. "A Novel Miniaturised Dynamic Hollow-Fibre Liquid-Phase Micro-Extraction Method for Xenobiotics in Human Plasma Samples." Doctoral thesis, Stockholms universitet, Institutionen för analytisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-41742.

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Bioanalytical chemistry is a challenging field, often involving complex samples, such as blood, plasma, serum or urine. In many applications, sample cleanup is the most demanding and time-consuming step. In the work underlying this thesis a novel dynamic miniature extractor, known as a hollow-fibre liquid-phase microextractor (HF-LPME), was designed, evaluated and studied closely when used to clean plasma samples. Aqueous-organic-aqueous liquid extraction, in which the organic liquid is immobilised in a porous polypropylene membrane, was the principle upon which the extractor was based, and this is discussed in all the papers associated with this thesis. This type of extraction is known as supported-liquid membrane extraction (SLM). The aim of this work was the development of a dynamic system for SLM. It was essential that the system could handle small sample volumes and had the potential for hyphenations and on-line connections to, for instance, LC/electrospray-MS. The design of a miniaturised HF-LPME device is presented in Paper I. The extraction method was developed for some weakly acidic pesticides and these were also used for evaluation. In the work described in Paper II, the method was optimised on the basis of an experimental design using spiked human plasma samples. Paper III presents a detailed study of the mass-transfer over the liquid membrane. The diffusion through the membrane pores was illustrated by a computer-simulation. Not surprisingly, the more lipophilic, the greater the retention of the compounds, as a result of dispersive forces. The main focus of the work described in Paper IV was to make the HF/LPME system more versatile and user-friendly; therefore, the extractor was automated by hyphenation to a SIA system.
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 4: Manuscript.
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Yen, Pei-Shan. "Supported Liquid Metal Membranes for Hydrogen Separation." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-dissertations/480.

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Hydrogen (H2) and fuel cells applications are central to the realization of a global hydrogen economy. In this scenario, H2 may be produced from renewable biofuels via steam reforming and by solar powered water electrolysis. The purification required for fuel cell grade H2, whether in tandem or in situ within a catalytic reformer operating at 500 oC or above, would be greatly facilitated by the availability a cheaper and more robust option to palladium (Pd) dense metal membrane, currently the leading candidate. Here we describe our results on the feasibility of a completely novel membrane for hydrogen separation: Sandwiched Liquid Metal Membrane, or SLiMM, comprising of a low-melting, non-precious metal (e.g., Sn, In, Ga) film held between two porous substrates. Gallium was selected for this feasibility study to prove of the concept of SLiMM. It is molten at essentially room temperature, is non-toxic, and is much cheaper and more abundant than Pd. Our experimental and theoretical results indicate that the Ga SLiMM at 500 oC has a permeability 35 times higher than Pd, and substantially exceeds the 2015 DOE target for dense metal membranes. For developing a fundamental understanding of the thermodynamics and transport in liquid metals, a Pauling Bond Valence-Modified Morse Potential (PBV-MMP) model was developed. Based on little input, the PBV-MPP model accurately predicts liquid metal self-diffusion, viscosity, surface tension, as well as thermodynamic and energetic properties of hydrogen solution and diffusion in a liquid metal such as heat of dissociative adsorption, heat of solution, and activation energy of diffusion. The concept of SLiMM proved here opens up avenues for development practical H2 membranes, For this, improving the physical stability of the membrane is a key goal. Consequently, a thermodynamic theory was developed to better understand the change in liquid metal surface tension and contact angle as a function of temperature, pressure and gas-phase composition.
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Zou, Yiran. "Gas separation using supported ionic liquid membranes." Thesis, Queen's University Belfast, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517535.

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Maxwell, Michael. "Functionalised poly(organosiloxane)s as supported liquid membranes." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311252.

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Lantto, Jonas. "Analytical model of mass transfer through supported liquid membranes." Thesis, KTH, Skolan för kemivetenskap (CHE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176912.

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This report details the development and validation of a model for the simulation of supported liquid membrane processes, as applied to the extraction of lanthanides. Supported liquid membranes are systems where two phases, usually aqueous, are separated by a third phase, typically organic, which acts as a membrane, in order to separate solutes from one phase to the other. The model employs an analytical solution to the diffusion equation for the organic phase and linear approximations of the resistances to mass transfer in the aqueous phase boundary layers. The goal of this model is to underline the importance of taking these boundary layer resistances into account.
Detta arbete introducerar, deriverar och evaluerar en matematisk modell för simulering av vätskemembranprocesser, tillämpat på vätskeextraktion av lantanider. Immobiliserade vätskemembran betecknar system där två faser oftast vatten, separeras av en tredje organisk fas som agerar membran för att separera och transportera lösta komponenter från den ena vattenfasen till den andra. Modellen utnyttjar sig av en analytisk lösning till diffusionsekvationen för den organiska fasen och linjära approximationer för motstånden mot masstransport i de båda vattenfasernas gränsskikt. Målet med modellen är att understryka vikten av att inkludera dessa gränsskikt i beräkningarna.
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Aziz, Mujahid. "The recovery of copper by tubular supported liquid membranes." Thesis, Cape Peninsula University of Technology, 2006. http://hdl.handle.net/20.500.11838/894.

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Thesis (MTech (Chemical Engineering))--Cape Peninsula University of Technology, Cape Town, 2006
During recent years, the use of liquid membranes has gained general interest in the treatment of effiuents where solute concentrations are low and large volumes of solutions should be processed, and, if possible, without generating any secondary waste. Liquid membrane processes have been proposed as a clean technology, owing to their characteristics, i.e. high specificity, low energy and utilization. Two liquid membrane processes have been used in metal recovery, which are the liquid surfactant membrane (LSM), which corresponds to double water-in-oil emulsion and solid . supported liquid membranes (SLM), which are made by dispersing or impregnating the extractant within the pores of in.ert solid support. Previously, the recovery of eu (IT) in a SLM system was conducted by other membrane models such as hollow fibre, spiral and flat sheet. Only a small measure of success on scale-up and industrialization of these models has been attained. One of the disadvantages of the hollow fibre system was the small lumen size through which the feed needed to pass. Pores became clogged by suspended particles because the pressure drop over the small diameter augments lower flow rates and therefore, pre-filtering is necessary (Rathore, et al., 2001). In this study the behaviour of a tubular SLM reactor with an inner diameter of the lumen approximately fifty times bigger than that of the hollow fibre are used in order to solve the problem of clogging. This tubular reactor was incorporated in to a bench scale plant and proved successful in copper extraction. By observing transient data, mass transport coefficients were determined and compared to published values.
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Yahaya, Garba Oloriegbe. "Facilitated transport in supported liquid membranes containing functionalized polyorganosiloxanes." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266467.

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Aroca, Arcaya German E. "Modelling the extraction of organic acids by supported liquid membranes." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262535.

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Books on the topic "Supported Liquid Membranes (SLM)"

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Bhatnagar, Atul P. Analytical preconcentration of metals by uphill transport across supported liquid membranes. 1989.

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Mani, Izdihar Abdul-Ahad. The influence of diluent selection upon the behaviour of supported liquid membranes. Bradford, 1988.

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Book chapters on the topic "Supported Liquid Membranes (SLM)"

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Kislik, Vladimir S. "Supported Liquid Membrane." In Encyclopedia of Membranes, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-40872-4_566-2.

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Kislik, Vladimir S. "Supported Liquid Membrane." In Encyclopedia of Membranes, 1858–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_566.

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Parhi, Pankaj Kumar, Saroj Sekhar Behera, Dindayal Mandal, Debadutta Das, and Ranjan Kumar Mohapatra. "Fundamental Principle and Practices of Solvent Extraction (SX) and Supported Liquid Membrane (SLM) Process for Extraction and Separation of Rare Earth Metal(s)." In Rare-Earth Metal Recovery for Green Technologies, 57–85. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-38106-6_4.

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Muscatello, Anthony C., James D. Navratil, and Marlene Y. Price. "Actinide Removal from Aqueous Waste Using Solid Supported Liquid Membranes." In Liquid Membranes, 182–89. Washington, DC: American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0347.ch013.

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Pietro, Argurio. "Strip Dispersion Supported Liquid Membrane." In Encyclopedia of Membranes, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-40872-4_556-5.

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Argurio, Pietro. "Strip Dispersion Supported Liquid Membrane." In Encyclopedia of Membranes, 1827–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_556.

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Irabien, Angel. "Supported Magnetic Ionic Liquid Membranes." In Encyclopedia of Membranes, 1862–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_1778.

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Irabien, Angel. "Supported Magnetic Ionic Liquid Membranes." In Encyclopedia of Membranes, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_1778-1.

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Van der Bruggen, Bart. "Pervaporation Through Supported Liquid Membrane." In Encyclopedia of Membranes, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-40872-4_457-1.

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Noble, Richard D., and Pier R. Danesi. "Steady-State Coupled Transport of HNO3Through a Hollow-Fiber Supported Liquid Membrane." In Liquid Membranes, 56–61. Washington, DC: American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0347.ch004.

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Conference papers on the topic "Supported Liquid Membranes (SLM)"

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Huang, Dushu, Wei Liu, Zhaolong Huang, Yashun Chen, Jing Wang, and Na Wu. "Enantioseparation of Enantiomers across Hollow Fiber Supported Liquid Membranes." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.195.

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Lee, Sin-Doo, Yong-Sang Ryu, and Sang-Hyun Oh. "Lipid sorting and leaflet coupling in supported membranes by curvature elasticity (Conference Presentation)." In Liquid Crystals XXII, edited by Iam Choon Khoo. SPIE, 2018. http://dx.doi.org/10.1117/12.2319820.

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Wickham, David T., Kevin J. Gleason, Jeffrey R. Engel, Scott W. Cowley, and Cinda Chullen. "Advanced Supported Liquid Membranes for CO2 Control in EVA Applications." In 43rd International Conference on Environmental Systems. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2013. http://dx.doi.org/10.2514/6.2013-3307.

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Oku, Naoki, Michiaki Matsumoto, and Kazuo Kondo. "Separation of Saccharides with Supported Ionic Liquid Membranes Containing Calixarenes as a Carrier." In 14th Asia Pacific Confederation of Chemical Engineering Congress. Singapore: Research Publishing Services, 2012. http://dx.doi.org/10.3850/978-981-07-1445-1_136.

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Toft, Gareth, Steve Cassidy, and Mark Lunn. "Supported Liquid Membranes For Carbon Dioxide Removal From Submarine Atmospheres: Experiences With A Technology Demonstrator." In 31st International Conference On Environmental Systems. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2001. http://dx.doi.org/10.4271/2001-01-2394.

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An, Hyeun Hwan, Seung Jae Lee, Hee-Soo Kim, Jong Ho Lee, and Chong Seung Yoon. "Photoluminescence from SnOx/Sn nanoparticle monolayer on solid-supported liquid-crystalline phopholipid membranes: Dioleoylphosphocholine, dioleoylphosphatidylethanolamine, dioleoyltrimethylammonium-propane." In 2011 IEEE 11th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2011. http://dx.doi.org/10.1109/nano.2011.6144376.

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Zhang, Li-Zhi. "Effects of Membrane Structural Parameters on Heat Mass Transfer Property of a Composite Supported Liquid Membrane." In ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62158.

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Supported liquid membranes have been used in many industries due to their inherent high mass transfer rates. In this study, the heat and moisture transfer through the composite supported liquid membrane is numerically investigated. The composite membrane comprises two hydrophobic skin layers and a hydrophilic porous layer in which a layer of LiCl solution is supported. Focus of this study is on the effects of membrane structural parameters such as pore diameters, porosity, tortuosity, and membrane thickness on the effective moisture diffusivity and the effective heat conductivity of the whole membrane. The established effective diffusivity and heat conductivity are combined with the heat and moisture conservation equations for air streams to calculate the temperature and humidity profiles in the unit. The variations of the effective diffusivity with membrane parameters are estimated.
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Tamaddoni, Nima, and Andy Sarles. "Characterizing the Sources of Current Generated by a Membrane-Based Hair Cell Sensor." In ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3141.

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Recently, researchers have developed a method to construct a membrane-based hair cell sensor that generates a measurable current in response to physical disturbance of the hair. Representing the cell membrane, a phospholipid bilayer is formed at the interface of two lipid-encased hydrophilic volumes and a hair is located in a center of one of the volumes act a shaking element. In this work, we study the current generated by free vibration of the hair in a revised hair cell embodiment that uses a hair that is physically supported by the surrounding substrate. The current generated by the sensor is measured by a patch clamp amplifier, and the net charge displaced across the membrane during motion of the hair is computed. Experiments performed with a complete hair cell sensor and various control cases that lack a bilayer indicate that the current measured at 0mV applied across the membrane is due to vibration of the positive electrode that changes the local electromagnetic field. Experiments conducted with both geland liquid-supported membranes indicate that gel-supported membranes have a higher sensitivity of (0.066 pC/mV) than liquid-supported membranes (0.015 pC/mV) as the applied voltage increases. Lastly, the motion of the tip of the hair is imaged using a high-speed camera. This test shows that the hair oscillates at the same frequency observed in the measured current traces, which indicates that transverse bending of the bilayer is the cause for the time rate of change in capacitance in the membrane that produces a voltage-dependent current.
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Taylor, Graham, Donald Leo, and Andy Sarles. "Detection of Botulinum Neurotoxin/A Insertion Using an Encapsulated Interface Bilayer." In ASME 2012 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/smasis2012-8101.

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Many signaling mechanisms in living cells occur at biological boundaries via cell surface receptors and membrane proteins embedded in lipid bilayers. The coordination of actions of sensory and motor neurons in the nervous system represents one example of many that heavily depends on lipid membrane bound receptor mediated signaling. As a result, chemical and biological toxins that disrupt these neural signals can have severe physiological effects, including paralysis and death. Botulinum neurotoxin Type A (BoNT/A) is a proteolytic toxin that inserts through vesicle membranes and cleaves membrane receptors involved with synaptic acetylcholine uptake and nervous system signal conduction. In this work, we investigate the use of a Bioinspired liquid-supported interface bilayer for studying the insertion of BoNT/A toxin molecules into synthetic lipid bilayers. DPhPC lipid bilayers are formed using the regulated attachment method (RAM), as developed by Sarles and Leo, and we perform current measurements on membranes exposed to BoNT/A toxin to characterize activity of toxin interacting with the synthetic bilayer. Control tests without toxin present are also presented. The results of these tests show an increase in the magnitude of current through the bilayer when the toxin is included. We interpret these initial results to mean that incorporation of BoNT/A toxin at a high concentration in an interface bilayer increases the permeability of the membrane as a result of toxin molecules spanning the thickness of the bilayer.
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Reports on the topic "Supported Liquid Membranes (SLM)"

1

Takigawa, D. Y. The effect of porous support composition and operating parameters on the performance of supported liquid membranes. Office of Scientific and Technical Information (OSTI), February 1991. http://dx.doi.org/10.2172/6235612.

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