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Dissertations / Theses on the topic 'Surgical procedures, Operative - handbooks'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2025

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1

Lou, Meei-Fang. "Cognitive disturbance among elderly Taiwanese patients after elective surgery /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7360.

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2

Le, Vi T. H. "Accurate modelling and positioning of a magnetically-controlled catheter tip." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2015. https://ro.ecu.edu.au/theses/1711.

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This thesis represents the initial phase of a proposed operator and patient friendly method designed to semi-automate the positioning and directing of an intravascular catheter in the human heart using a variable electromagnetically induced field to control a catheter tip equipped with three tiny fixed magnets oriented in XYZ planes. Here we demonstrate a comprehensive mathematical model which accurately calculates the magnetic field generated by the electromagnet system, and the magnetic torques and forces exerted on a three-magnet tip catheter. From this we have developed an iterative predic
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3

Cuming, Richard G. "Factors Surgical Team Members Perceive Influence Choices of Wearing or not Wearing Personal Protective Equipment During Operative/Invasive Procedures." FIU Digital Commons, 2009. http://digitalcommons.fiu.edu/etd/111.

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Exposure to certain bloodborne pathogens can prematurely end a person’s life. Healthcare workers (HCWs), especially those who are members of surgical teams, are at increased risk of exposure to these pathogens. The proper use of personal protective equipment (PPE) during operative/invasive procedures reduces that risk. Despite this, some HCWs fail to consistently use PPE as required by federal regulation, accrediting agencies, hospital policy, and professional association standards. The purpose of this mixed methods survey study was to (a) examine factors surgical team members perceive influen
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4

Nordin, Pär. "Groin hernia surgery : studies on anaesthesia and surgical technique /." Linköping : Univ, 2003.

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5

Franco, Fernando Fabricio 1978. "Incidência de embolia gordurosa pós-cirurgia de lipoaspiração com ou sem lipoenxertia = estudo em animais." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313795.

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Orientadores: Alfio José Tincani, Luciana Rodrigues de Meirelles<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-18T22:17:19Z (GMT). No. of bitstreams: 1 Franco_FernandoFabricio_D.pdf: 2115089 bytes, checksum: b74f7a822f16bf0228730d3a2f4ab28a (MD5) Previous issue date: 2011<br>Resumo: Introdução: A lipoaspiração é um procedimento cirúrgico que consiste na retirada do excesso de tecido gorduroso localizado, em indivíduos saudáveis. Este procedimento, que muito aumentou nas últimas décadas em todo o mundo, pode ser a
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Cirino, Camila Camarinha da Silva 1986. "Avaliação clínica do tratamento cirúrgico e não-cirúrgico de pacientes com periodontite agressiva." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290416.

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Orientador: Antônio Wilson Sallum<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-22T19:02:53Z (GMT). No. of bitstreams: 1 Cirino_CamilaCamarinhadaSilva_M.pdf: 1347661 bytes, checksum: 1541e9727de891711daaa2773bd8086f (MD5) Previous issue date: 2013<br>Resumo: O presente estudo tem como objetivo avaliar, por meio dos parâmetros clínicos, o efeito das terapias periodontais cirúrgica e não-cirúrgica no tratamento da periodontite agressiva generalizada (PAG). Doze pacientes portadores de periodontite ag
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7

Calhoun, William R. III. "Femtosecond Laser Beam Propagation through Corneal Tissue: Evaluation of Therapeutic Laser-Stimulated Second and Third-Harmonic Generation." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3785.

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One of the most recent advancements in laser technology is the development of ultrashort pulsed femtosecond lasers (FSLs). FSLs are improving many fields due to their unique extreme precision, low energy and ablation characteristics. In the area of laser medicine, ophthalmic surgeries have seen very promising developments. Some of the most commonly performed surgical operations in the world, including laser-assisted in-situ keratomileusis (LASIK), lens replacement (cataract surgery), and keratoplasty (cornea transplant), now employ FSLs for their unique abilities that lead to improved clinical
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Oliveira, Murielly Marques de. "Fadiga em pacientes submetidos à cirurgia oncológica: uma coorte prospectiva." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5434.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-04-04T20:48:58Z No. of bitstreams: 2 Dissertação - Murielly Marques de Oliveira - 2015.pdf: 1844632 bytes, checksum: 65930abae56d5ad1aa3bf4d25d2a30ae (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-05T11:11:26Z (GMT) No. of bitstreams: 2 Dissertação - Murielly Marques de Oliveira - 2015.pdf: 1844632 bytes, checksum: 65930abae56d5ad1aa3bf4d25d2a30ae (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e3
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Campos, Fabrício Ribeiro de. "Prevalência de infecção de sítio cirúrgico em pacientes adultos num hospital geral do interior paulista." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-17012017-160117/.

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Introdução: As Infecções Relacionadas à Assistência á Saúde (IRAS) são consideradas um problema de saúde pública com implicações sociais e econômicas graves que geram sobrecarga nas instituições de saúde, aumentando o período de internação e elevando consideravelmente a morbimortalidade em pacientes hospitalizados. A infecção do sítio cirúrgico (ISC) se constitui como uma das mais temidas complicações decorrentes dos procedimentos cirúrgicos No Brasil, são escassos os estudos epidemiológicos sobre as infecções em pacientes submetidos à procedimentos anestésico cirúrgico. Objetivo: Id
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10

Pinto, Fabiana de Souza. "Atenção auditiva e consciência fonológica em crianças com fissura labiopalatina com palatoplastia primária de 9 a 12 meses de idade." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/25/25143/tde-12062012-150656/.

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A fissura labiopalatina é uma malformação craniofacial congênita caracterizada pelo não fechamento do lábio e/ou palato. Várias podem ser as consequências trazidas por essa ruptura como alterações na fala, deglutição, mastigação, dentárias e auditivas. Diante disso, esses pacientes necessitam passar por cirurgias reparadoras, sendo a idade em que acontecerá um fator fundamental para que desenvolvimento das funções auditivas e orofaciais se encontre dentro do esperado ou próximo a ele. Há grande relação entre a fissura e alterações de orelha média, tendo como consequência a privação sensorial m
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11

Weber, Lebrun Emily Elise. "Factors Associated with Subjective Improvement Following Midurethral Sling Procedures for Stress Urinary Incontinence: A Masters Thesis." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/466.

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Background Female stress urinary incontinence (SUI) greatly affects quality of life. The midurethal sling (MUS) procedure has been widely accepted as the standard of care treatment for SUI, although there is little information regarding patients' subjective reports of symptom improvement. Objectives The objective of this study was to identify clinical and demographic characteristics that predict subjective symptom improvement following MUS procedures in women with SUI. Materials and Methods The study design was retrospective cohort. Subjects included women who underwent MUS between 2006 and 20
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12

Zogaib, Rodrigo Kallás 1973. "Osteossíntese minimamente invasiva com uso de placas em ponte das fraturas transversas da diáfise do úmero (Classificadas pela Ao-Assif como 12.A3)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308489.

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Orientador: Bruno Livani<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-22T13:03:57Z (GMT). No. of bitstreams: 1 Zogaib_RodrigoKallas_M.pdf: 9326160 bytes, checksum: a09bd895633ff41c62b544b7b84de884 (MD5) Previous issue date: 2013<br>Resumo: Entre novembro de 2000 e abril de 2011, 22 pacientes com 23 fraturas transversas da diáfise umeral foram tratados com redução indireta e fixação com placa e parafusos através de técnica minimamente invasiva. A seguimento pós-operatório variou de 6 a 126 meses ( media 51.
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13

Yoneda, Juliana Yoko 1984. "Fatores patológicos relacionados ao tratamento cirúrgico dos carcinomas microinvasores do colo do útero." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312847.

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Orientadores: Luiz Carlos Zeferino, Joana Fróes Bragança Bastos<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T05:47:30Z (GMT). No. of bitstreams: 1 Yoneda_JulianaYoko_M.pdf: 1509037 bytes, checksum: 64a492fd2dcabf75db665898f34f50aa (MD5) Previous issue date: 2014<br>Resumo: Objetivos: Avaliar fatores patológicos em mulheres submetidas à histerectomia radical e linfadenectomia pélvica bilateral para tratamento de câncer do colo do útero estádio IA1 com invasão angiolinfática e IA2, correlacionando achados
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14

Kadri, Paulo Abdo do Seixo. "Interrupção das fibras brancas nos acessos cirúrgicos ao corno temporal do ventrículo lateral: estudo anatômico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-11042016-110930/.

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Introdução: A exploração cirúrgica do como temporal do ventrículo lateral (CTVL) é realizada para o tratamento de lesões neoplásica, vasculares e, principalmente, para o tratamento cirúrgico da epilepsia do lobo temporal. As abordagens cirúrgicas a esta cavidade são realizadas, a partir da superficie cortical e através de suas paredes, pelos acessos laterais, transsilvianos e inferiores. A escolha do acesso cirúrgico se baseia na exposição adequada e nas alterações neurológicas que possam advir do trauma ao parênquima cerebral. A secção dos diferentes feixes de fibras brancas pode resultar em
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15

Júnior, Mário Fernandes Chammas. "Avaliação do tratamento cirúrgico da obstrução da junção pielo-ureteral por meio de pieloplastia vídeo-laparoscópica robótica assistida." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-24032016-112034/.

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Objetivo: Avaliar os resultados iniciais e a curva de aprendizado dos primeiros 100 casos consecutivos do tratamento cirúrgico da obstrução da junção ureteropiélica por meio da pieloplastia robótica laparoscópica. Materiais e Métodos: Um total de 99 pacientes (41 homens e 58 mulheres), com idade média de 38 anos (18-81 anos), foi submetido a 100 pieloplastias robóticas laparoscópicas consecutivas (um procedimento bilateral), realizadas pelo mesmo cirurgião. A determinação da curva de aprendizado foi baseada na avaliação do tempo de anastomose, tempo cirúrgico, complicações precoces e tardias e
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16

Hoang, Chau Maggie. "National Trends in Elective Ileal Pouch-Anal Anastomosis for Ulcerative Colitis." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/976.

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Background: Recent national trends and distribution of ileal pouch-anal anastomosis (IPAA) procedures for patients with ulcerative colitis (UC) are unknown. We examined the frequency of use of elective IPAA procedures among patients with UC and the distribution of IPAA procedures across more than 140 U.S. academic medical centers and their affiliates. Methods: Data were obtained from the University HealthSystem Consortium for patients with a primary diagnosis of UC admitted electively between 2012 and 2015. Results: The mean age of the study population (n=6,875) was 43 years and 57% were men.
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17

Millan, Tatiana 1977. "Resultados de cirurgia monocular de estrabismo de grande angulo sob anestesia peribulbar." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310198.

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Orientador: Keila Miriam Monteiro de Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T19:40:07Z (GMT). No. of bitstreams: 1 Millan_Tatiana_M.pdf: 2201742 bytes, checksum: 9fbc6126d8358be88ca29d8f5d863b72 (MD5) Previous issue date: 2007<br>Resumo: Objetivo: Avaliar os resultados da cirurgia monocular na correção de estrabismos horizontais de grande ângulo sob anestesia peribulbar. Métodos: Foram avaliados 92 pacientes submetidos à cirurgia monocular de estrabismo horizontal de grande ângulo (ângulo
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18

Khushalani, Jaya Shankar. "Racial and Ethnic Differences in Receipt of Immediate Breast Reconstruction Surgery: Do Hospital Characteristics Matter?" VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/4967.

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Immediate Breast Reconstruction Surgery (IBRS) is associated with better quality of life among women who undergo a mastectomy. Despite insurance coverage for IBRS, utilization of IBRS remains low. Data from publicly available sources for 2010-2012 are used to examine the association between hospital characteristics receipt of IBRS by patients. Minority-serving status, low bed size, for-profit ownership, non-teaching status, high competition, low density of plastic surgeons in the market and non-metropolitan location are associated with lower likelihood of receipt of IBRS. Racial and ethnic min
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19

Schmitt, Cristiane. "Características e iniciativas institucionais que aprimoram as práticas de uso de antibioticoprofilaxia cirúrgica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-20072015-155313/.

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Introdução: Os eventos adversos relacionados à assistência à saúde estão associados ao aumento da morbimortalidade e as IRAS correspondem entre 15% a 25% desses eventos. Há escassez de novos antimicrobianos, aumento de cepas resistentes e alto consumo dessas drogas. A adesão às diretrizes de antibioticoprofilaxia cirúrgica é pouco satisfatória e no Brasil há poucos dados sobre o assunto. Objetivo: reconhecer as características e iniciativas institucionais que aprimoram as práticas de uso de antibioticoprofilaxia em neurocirurgia. Objetivos específicos: identificar a conformidade; verificar a a
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20

Bueno, Sávia Christina Pereira. "Estudo da segurança e da estabilidade do implante de cabo-eletrodo atrial direito pela via epidemiocárdiaca através do seio transverso em modelo animal suíno." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-16092013-162851/.

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Introdução: Embora o implante de marcapasso atrioventricular pela via endovenosa seja considerado o estado da arte, situações clínicas e técnicas que podem impossibilitar o implante transvenoso de cabos-eletrodos têm sido cada vez mais frequentes, tornando-se necessária a proposição de abordagens cirúrgicas alternativas. Objetivos: O presente estudo visou o implante de marcapasso atrioventricular utilizando nova técnica para implante de cabo-eletrodo atrial no átrio direito, com o objetivo de avaliar no período intra-operatório e nos 30 primeiros dias de seguimento: a segurança e a reprodutibi
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21

Feldner, Junior Paulo Cezar [UNIFESP]. "Tratamento cirúrgico da distopia de parede vaginal anterior: comparação entre tela biológica e colporrafia tradicional." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10133.

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Made available in DSpace on 2015-07-22T20:50:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-11-25. Added 1 bitstream(s) on 2015-08-11T03:25:36Z : No. of bitstreams: 1 Publico-045.pdf: 1293717 bytes, checksum: aa77a18d9ad66fac463c08766304abf5 (MD5)<br>Objetivo: avaliar os resultados anatômicos, funcionais e complicações do tratamento do prolapso da parede vaginal anterior com tela de submucosa de intestino delgado suíno (SIS) e com colporrafia anterior. Pacientes e Métodos: estudo prospectivo e randomizado para comparação do uso de tela de SIS e de colporrafia tradicional. As mul
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22

Dinsmore, Kristen, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy PhD Brown, and Alexei MD Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for skin testing after perioperative anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/146.

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Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilutio
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23

Kondo, André. "Abordagem endoscópica comparada à cirúrgica no tratamento do câncer gástrico precoce: revisão sistemática e metanálises." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-06022017-105830/.

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Os desfechos clínicos e oncológicos dos pacientes submetidos à ressecção endoscópica do câncer gástrico precoce (CGP), considerando os critérios de indicação, comparados à cirurgia, não foram relatados em revisões sistemáticas. A pesquisa foi desenvolvida para estabelecer os desfechos de curto e longo prazos da ressecção endoscópica comparada à cirurgia no tratamento do CGP, elevando as informações para o nível de evidência 2a, melhor respaldando a prática clínica. A revisão sistemática com metanálises foi procedida utilizando-se as bases Medline, Embase, Cochrane, LILACS, Scopus e CINAHL. Onz
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Soares, Iracy Silvia Corrêa. "Sensibilização ao látex em pacientes com mielomeningocele na urologia do HC-FMUSP: prevalência e fatores associados." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-20052016-102431/.

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INTRODUÇÃO: A alergia ao látex é um importante problema de saúde pública, especialmente em grupos de risco que têm contato frequente com este potente alérgeno. Este estudo estimou a prevalência e os fatores de risco para sensibilização ao látex em pacientes com mielomeningocele (MMC) submetidos a procedimentos cirúrgicos urológicos no HC-FMUSP. MÉTODOS: Foram selecionados pacientes com MMC submetidos a pelo menos uma cirurgia urológica, entre 2009 e 2014.Todos foram entrevistados e seus prontuários revisados. Uma amostra de sangue permitiu que a IgE específica ao látex, a K82, e seus recombina
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Chueh, Juyu. "Mechanical Flow Restoration in Acute Ischemic Stroke: A Model System of Cerebrovascular Occlusion: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/493.

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Stroke is the third most common cause of death and a leading cause of disability in the United States. The existing treatments of acute ischemic stroke (AIS) involve pharmaceutical thrombolytic therapy and/or mechanical thrombectomy. The Food and Drug Administration (FDA)-approved recombinant tissue plasminogen activator (tPA) administration for treatment of stroke is efficacious, but has a short treatment time window and is associated with a risk of symptomatic hemorrhage. Other than tPA, the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) retriever system and the Penumbra Aspiration
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Lambert, Julie. "Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/344.

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NOD mice model human type 1 diabetes and have been used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. Costimulation blockade-based tolerance protocols that induce prolonged skin and permanent islet allograft survival in non-autoimmune mice have failed in NOD mice. To investigate the underlying mechanisms, we generated NOD hematopoietic chimeras. We were able to show that dendritic cell maturation defects seen in NOD mice are partially corrected in mixed hematopoietic chimeras. Furthermore, skin allograft survival was dependent upon the phe
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Menegueti, Katia Ignacio. "Perfil da fala de pacientes submetidos à palatoplastia primária." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-06122016-160112/.

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Diversas alterações anatômicas e funcionais são observadas como consequência da fissura labiopalatina, ocasionando alterações em relação ao crescimento do terço médio da face, à audição e a funcionalidade do esfíncter velofaríngeo. Esta última interfere diretamente nas funções de sucção, deglutição e fala. O objetivo deste estudo é caracterizar o perfil da fala de pacientes submetidos à palatoplastia primária em um hospital escola de referência da cidade de São Paulo, levando-se em consideração a idade do paciente no momento da cirurgia. Os objetivos específicos são a análise da eficácia da ci
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28

Cabral, Danielle Bezerra. "Micobactérias não tuberculosas em cirurgias: desafio passível de enfrentamento no Brasil?" Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-27092010-163220/.

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Micobactérias não tuberculosas (MNT) são microrganismos ubíquos e reconhecidos como contaminantes de sistemas de água em estabelecimentos de assistência à saúde, bem como, dispositivos cirúrgicos e medicamentos injetáveis. Sua ocorrência representa uma emergência epidemiológica e sanitária, especialmente em pacientes submetidos a procedimentos cirúrgicos. Frente ao exposto, objetivou-se avaliar a produção do conhecimento científico acerca da ocorrência de infecções por MNT em pacientes submetidos a procedimentos cirúrgicos. A prática baseada em evidências representou o referencial teórico-meto
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Collins, Courtney E. "Gender Differences in Choice of Procedure and Case Fatality Rate for Elderly Patients with Acute Cholecystitis: A Masters Thesis." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/806.

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Background: Treatment decisions for elderly patients with gallbladder pathology are complex. Little is known about what factors go into treatment decisions in this population. We used Medicare data to examine gender-based differences in the use of cholecystectomy vs. cholecystostomy tube placement in elderly patients with acute cholecystitis. Methods: We queried a 5% random sample of Medicare data (2009-2011) for patients >65 admitted for acute cholecystitis (by ICD-9 code) who subsequently underwent a cholecystectomy and/or cholecystostomy tube placement. Demographic information (age, race),
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Welleford, Andrew. "Autologous Peripheral Nerve Grafts to the Brain for the Treatment of Parkinson's Disease." UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/23.

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Parkinson’s disease (PD) is a disorder of the nervous system that causes problems with movement (motor symptoms) as well as other problems such as mood disorders, cognitive changes, sleep disorders, constipation, pain, and other non-motor symptoms. The severity of PD symptoms worsens over time as the disease progresses, and while there are treatments for the motor and some non-motor symptoms there is no known cure for PD. Thus there is a high demand for therapies to slow the progressive neurodegeneration observed in PD. Two clinical trials at the University of Kentucky College of Medicine (NCT
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Vedala, Krishnatej. "A Novel Signal Processing Method for Intraoperative Neurophysiological Monitoring in Spinal Surgeries." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/1038.

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Intraoperative neurophysiologic monitoring is an integral part of spinal surgeries and involves the recording of somatosensory evoked potentials (SSEP). However, clinical application of IONM still requires anywhere between 200 to 2000 trials to obtain an SSEP signal, which is excessive and introduces a significant delay during surgery to detect a possible neurological damage. The aim of this study is to develop a means to obtain the SSEP using a much less, twelve number of recordings. The preliminary step involved was to distinguish the SSEP with the ongoing brain activity. We first establish
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32

Miller, David M. "TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/368.

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Costimulation blockade based on a donor-specific transfusion and anti-CD154 mAb is effective for establishing mixed allogeneic hematopoietic chimerism and inducing transplantation tolerance. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation that activate toll-like receptors (TLR). TLR agonists prevent costimulation blockade-induced prolongation of solid organ allografts, but their effect on the establishment of hematopoietic chimerism has not been reported. In this disserta
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Thornley, Thomas B. "IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/254.

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Costimulation blockade protocols are promising alternatives to the use of chronic immunosuppression for promoting long-term allograft survival. However, the efficacy of costimulation blockade-based protocols is decreased by environmental insults such as viral infections. For example, lymphocytic choriomeningitis virus (LCMV) infection at the time of costimulation blockade treatment abrogates skin allograft survival in mice. In this dissertation, we test the hypothesis that viruses shorten allograft survival by activating the innate immune system through pattern-recognition receptors (PRRs), su
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34

Oliveira, Daiane da Silva. "Caracterização do perfil epidemiológico do paciente com câncer de reto no Instituto do Câncer do Estado de São Paulo: determinação dos fatores associados ao tempo de internação hospitalar do paciente cirúrgico." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-07082017-103926/.

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INTRODUÇÃO: A despeito de todos os avanços no tratamento cirúrgico do câncer, ainda existem fatores complicadores para a adequada evolução no pós-operatório. Realizou-se estudo retrospectivo em uma população de pacientes submetidos a tratamento cirúrgico oncológico eletivo para o câncer retal, a fim de caracterizá-los epidemiologicamente e determinar quais variáveis estão associadas a maior morbimortalidade tais como aumento de permanência hospitalar, utilização de unidade de terapia intensiva, reoperações, óbito em 30 dias e custos hospitalares totais. MÉTODO: Foram selecionados todos os paci
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Mendonça, Ernesto Quaresma. "Tratamento endoscópico versus cirúrgico para adenomas de papila: revisão sistemática e metanálises." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-31072017-153717/.

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Objetivos: Avaliar os desfechos da ressecção endoscópica em comparação à cirurgia no tratamento dos adenomas de papila. Métodos: Foi realizada uma revisão sistemática com metanálise de acordo com as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). As bases de dados Medline, Embase, Cochrane, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scopus and Cumulative Index to Nursing and Allied Health Literature (CINAHL) foram escaneadas. Os estudos incluíram pacientes com adenoma de papila e dados de comparação dos tratamentos endos
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36

Garcia, Diogo de Freitas Valeiro. "Uso dos modelos SurgeMan®, TraumaMan® e Porcino na prática cirúrgica do curso Suporte Avançado de Vida no Trauma (SAVT)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-01032017-122338/.

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Introdução: Universidades e hospitais solicitam alternativas para o uso de animais no treinamento médico sempre que possível. O custo dos manequins artificiais atualmente aprovados pelo Colégio Americano de Cirurgiões muitas vezes torna o seu uso proibitivo em países em desenvolvimento e subdesenvolvidos. Um manequim artificial de baixo custo (SurgeMan®) foi desenvolvido no Brasil. Nosso objetivo primário foi determinar se o SurgeMan® é adequado de acordo com o grau de satisfação dos alunos e instrutores do programa ATLS® quando comparado com o modelo TraumaMan® e o modelo animal, que são os a
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King, Marie A. "The Humanized Mouse Model: The Study of the Human Alloimmune Response: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/374.

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The transplantation of allogeneic cells and tissues for the treatment of human disease has been a life-saving procedure for many thousands of patients worldwide. However, to date, neither solid organ transplantation nor bone marrow transplantation have reached their full clinical potential. Significant limitations to the advancement of clinical transplantation stem from our current inability to prevent the rejection of allogeneic tissues by the immune system of the host. Similarly, in patients that receive allogeneic bone marrow transplants, we cannot permanently prevent the engrafted immune s
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38

Chang, Serena Soyoung Yunmee. "Toll-Like Receptors: Target of Hepatitis C Virus: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/386.

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Hepatitis C Virus (HCV) is the primary cause of liver transplantation due to its chronic nature in up to eighty percent of infected cases. Around 3 percent of the world’s population is infected with HCV. Treatment for HCV is a combined Ribavirin and interferon-α (IFN-α) therapy effective in only fifty to eighty percent of patients depending on HCV genotype. The growing health concern with this disease is the lack of a cure despite liver transplantation. HCV targets hepatocytes, liver cells, but is not cytolytic. HCV has been shown to induce end stage liver disease through sustained inflammatio
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Yang, Xiaoqing. "Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/563.

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Breast cancer is one of the most prevalent cancers in the world. Each year, over 400,000 women die from breast cancer world wide and metastasis is the main cause of their mortality. Tumor cell invasion into the adjacent tissue is the first step in the multistep process of cancer metastasis and it involves multiple protein changes. The α6β4 integrin, a transmembrane heterodimeric laminin receptor is associated with poor prognosis in many tumor types, including breast cancer. Src family kinase (SFK) activity is elevated in many cancers and this activity also correlates with invasive tumor behavi
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40

Sinikumpu, J. J. (Juha-Jaakko). "Forearm shaft fractures in children." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526203003.

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Abstract There are previous reports of an increasing incidence of children’s forearm fractures in the last few decades. Their surgical treatment is evolving. The present study was aimed at determining the incidence and background of these fractures and their treatment. It was also aimed to analyse the short- and long-term outcomes. A comprehensive population-based study (N=168) among 86,000 children in Oulu University Hospital District over a decade (2000–2009) was performed to analyse the incidence of middle-third forearm fractures. Further data (N=291) covering 1997–2009 was achieved in orde
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41

Radoje, Simić. "Kliničke i patohistološke karakteristike urođenog rascepa vrata u prednjoj srednjoj liniji i njihov značaj za diferencijalnu dijagnozu i hirurško lečenje." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94511&source=NDLTD&language=en.

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Urođeni rascep sa naborom u prednjoj srednjoj liniji vrata (UR-N PSLV) je retka anomalija sa oko 100-150 bolesnika opisanih u literaturi. Tipičan rascep se sastoji od atrofične, ružičaste kože u obliku žleba, kožne prominencije na gornjem kraju i potkožnog sinusa na donjem kraju tzv. rascepa. Ispod ovih elemenata nalazi se potkožna vezivno-mi&scaron;ićna traka koja izaziva nabor na vratu. Izolovani nabor vrata, kao jedan od tipova rascepa, ima samo potkožnu traku i podbradnu kožnu izraslinu. U radu analiziramo seriju od 11 bolesnika sa UR-N PSLV operisanih u periodu od 12 godina (jul 1998. - j
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42

Whalen, Michael. "Treating GM1 Gangliosidosis With Ex Vivo Hematopoietic Stem Cell Gene Therapy Without Using Total Body Irradiation: A Masters Thesis." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/558.

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GM1 gangliosidosis is an autosomal recessive lysosomal storage disease, caused by a deficiency in the enzyme β-galactosidase. The disease affects the CNS, liver, kidney, heart and skeletal system, leading to severe neurodegeneration and death. We propose to treat this disorder using ex vivo hematopoietic stem cell therapy. The effectiveness of this therapy requires the recruitment of transduced donor cells to the CNS. This is only found to occur after mice are conditioned with total body irradiation, due to the increase in CNS cytokine production and blood brain barrier permeability that occur
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43

Zambon, Camila Eduarda. "Estudo da variação das medidas ortodônticas e da função respiratória nasal por rinometria acústica e rinomanometria em pacientes submetidos à expansão palatina cirurgicamente assistida." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-27052010-160219/.

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Introdução: A atresia transversa da maxila é a discrepância volumétrica existente entre a maxila e a mandíbula no plano transversal que, além de alterações dento-esqueléticas, gera mudanças craniofaciais importantes, como o estreitamento das cavidades nasais, a diminuição da permeabilidade nasal e a respiração bucal. A expansão palatina cirurgicamente assistida (EPCA) é a técnica cirúrgica indicada para a correção da atresia maxilar em pacientes adultos, com o crescimento ósseo finalizado. A rinometria acústica é uma técnica objetiva de estudo da respiração nasal, com a qual se avalia a geomet
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44

Pearson, Todd. "The Genetic Basis of Resistance to Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/16.

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The NOD mouse is a widely studied model of type 1 diabetes. The loss of self-tolerance leading to autoimmune diabetes in NOD mice involves at least 27 genetic loci. Curing type I diabetes in mice and humans by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction would be preferable. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation blockade using donor-specific transfusion and anti-CDl54 antibody.
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Forman, Daron. "Viral Abrogation of Stem Cell Transplantation Tolerance Causes Graft Rejection and Host Death by Different Mechanisms: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/72.

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Tolerance-based stem cell transplantation using sub-lethal conditioning is being considered for the treatment of human disease, but safety and efficacy remain to be established. In order to study these two issues, we first established that mouse bone marrow recipients treated with sub-lethal irradiation plus transient blockade of the CD40-CD154 costimulatory pathway develop permanent hematopoietic chimerism across allogeneic barriers. Our conditioning regimen of 6 Gy irradiation, a short course of anti-CD154 mAb and 25 million fully allogeneic BALB/c bone marrow cells consistently produced lon
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46

Gandek, Barbara L. "Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/752.

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Background: Patient reports of pain and function are used to inform the need for and timing of total knee replacement (TKR) and evaluate TKR outcomes. This dissertation compared measurement properties of commonly-used patient surveys in TKR and explored ways to develop more efficient knee-specific function measures. Methods: 1,179 FORCE-TJR patients (mean age=66.1, 61% female) completed questionnaires before and 6 months after TKR. Patient surveys included the knee-specific Knee injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (W
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47

Gandek, Barbara L. "Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/752.

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Background: Patient reports of pain and function are used to inform the need for and timing of total knee replacement (TKR) and evaluate TKR outcomes. This dissertation compared measurement properties of commonly-used patient surveys in TKR and explored ways to develop more efficient knee-specific function measures. Methods: 1,179 FORCE-TJR patients (mean age=66.1, 61% female) completed questionnaires before and 6 months after TKR. Patient surveys included the knee-specific Knee injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (W
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48

Damle, Rachelle N. "Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/739.

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Background: Following passage of the Affordable Care Act in 2010, 30-day hospital readmissions have come under greater scrutiny. Excess readmissions for certain medical conditions and procedures now result in penalizations on all Medicare reimbursements. We examined the risk factors, outcomes, and costs of 30-day readmissions after colorectal surgery (CRS). Methods: The University HealthSystem Consortium database was queried for adults (≥ 18 years) who underwent colorectal resection for cancer, diverticular disease, inflammatory bowel disease, or benign tumors between January 2008 and December
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49

Seung, Edward. "CD40-CD154 Blockade Facilitates Induction of Allogeneic Hematopoietic Chimerism and Transplantation Tolerance: A Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/103.

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Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic potential. Establishment of hematopoietic chimerism created by stem cell transplantation has been shown to prevent and cure a number of autoimmune diseases and induce the most robust and long-lasting form of transplantation tolerance known. However, the realization of the vast clinical potential of hematopoietic chimerism for induction of transplantation tolerance has been impeded by the toxicity of the host conditioning regimen and the development of graft-versus-host disease (GVHD). This thesis descri
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50

Campos, Junior Eumildo de. "Complicações cardiovasculares em pacientes com megaesôfago chagásico submetidos à cirurgia de Serra Dória." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/139.

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Made available in DSpace on 2016-01-26T12:51:37Z (GMT). No. of bitstreams: 1 eumildodecampos junior_tese.pdf: 1761590 bytes, checksum: 07f0e6564f9169c180cc6baf09d6de84 (MD5) Previous issue date: 2011-12-16<br>Dysphagia caused by chagasic megaesophagus compromises the clinical status and quality of life of patients. In this context, the Serra Dória s operation is a useful procedure in cases of advanced or recurrent disease. Little is known about the cardiovascular complications related to this surgery. Objective: This study aim to identify preoperative risk factors associated with cardiovascu
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