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Dissertations / Theses on the topic 'Sustain Release'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Narvekar, Priya P. "Axitinib Loaded PLGA nanoparticles for Age-Related Macular Degeneration." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7866.

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Despite of all the research going on for the treatment of ocular diseases, age-related macular degeneration (AMD) remains one of the serious vision threatening disease worldwide. Choroidal neovascularization, a pathophysiological characteristic of wet AMD, is the growth of anomalous blood vessels in the eye choroidal layer. Neovascularization is a key factor in AMD and thus anti-angiogenic therapy is beneficial in reducing the development of new abnormal blood vessels to prevent progression of AMD. Axitinib, multi-receptor tyrosine kinase inhib

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2

Kim, Hyuncheol. "Study of ocular transport of drugs released from a sustained release device." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/251.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Chemical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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3

Awosika, Ajoritsedere. "Biopharmacy of sustained-release theophylline." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257819.

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4

Cook, Robert Owen. "Sustained release microparticles for pulmonary administration." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408442.

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5

Purkiss, Ronald. "Bioequivalence of sustained release theophylline formulations." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12472/.

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The bioequivalence of sustained release theophylline formulations, marketed in the United Kingdom, has been investigated in relation to the co-administration of food in both single dose and steady state volunteer studies. The effect of food on pharmacokinetic parameters and their clinical relevance was researched. Experimentation using drug induced modification of gastric motility to ascertain the component influences of the rate of gastric emptying on the absorption of theophylline from sustained release formulations was conducted. Prolongation of time to maximum plasma theophylline concentra

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6

Coleman, M. D. "Studies on the release of pyrimethamine from conventional and sustained release preparations." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356260.

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7

Mantzavinou, Aikaterini. "Sustained-release implants for intraperitoneal cisplatin delivery." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120884.

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Thesis: Ph. D. in Medical Engineering, Harvard-MIT Program in Health Sciences and Technology, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 217-226).<br>The objective of this work was to develop materials for continuous low-dose delivery of cisplatin directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown particular promise in treating advanced ovarian cancer. It is however tremendously underutilized beca

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8

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid

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9

Shah, Iftikhar Ali. "Chemotherapy with activated charcoal adsorbed mitocycin-C." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275012.

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10

Lowry, Deborah. "Sustained release strategies for HIV microbicides and vaccines." Thesis, Queen's University Belfast, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486247.

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Human immunodeficiency virus (HIV) lolls more people worldwide than' any other infectious disease. The main mode of transmission of HN is unprotected heterose~al intercourse with an infected partner. There is a need for the development of female controlfed preventative strategies. the most promising approach currently being pursued is the development of vaginally administeled HN. microbicides. The release profiles from silicone intravaginal rings (lVRs) of (i) potential HN fusion inhibitors. dextran sulfate (OS) and ceJJuJose sulfate (CS). (ii) organic acid species, and .(iii) bovine serum alb

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11

Fetherston, S. M. "Novel Sustained Release Divices for Vaginal Drug Administration." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527695.

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12

Dennis, Andrew Barriball. "Sustained drug release from semi-solid capsule formations." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328069.

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13

Lee, Jobina J. N. "Investigations into sustained-release hydrophobic matrix pellet formulations." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275167.

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14

Mhaka, Farai Arthur. "Development and manufacture of sustained release captopril beads." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/54712.

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Hypertension has a high mortality rate in developing countries such as South Africa. Although the prevention and control of hypertension is a health priority, efforts to decrease the global burden of hypertension and improve control over the condition are inadequate. The use of angiotensin converting enzyme (ACE) inhibitors such as captopril (CPT) have been effective for the management of hypertension when used as first line therapy alone or in combination. Commercially available immediate release dosage forms containing 12.5, 25 and 50 mg of CPT are administered two or three times a day to tr

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15

Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation wer

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16

Awang, Mohamed Bin. "Radiolabelling of pharmaceutical dosage forms by neutron activation of Samarium-152." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261026.

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17

Wagner, Daniel. "Sustained release formulations for compounds underlying intestinal drug efflux." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=96927890X.

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18

Wilding, Ian Robert. "Some studies of oral sustained release of pellet systems." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319343.

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19

Sachikonye, Tinotenda Chipo Victoria. "Development and assessment of minocycline sustained release capsule formulations." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013127.

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The use of minocycline for the treatment of a broad range of systemic infections and for severe acne has been associated with vestibular side effects. The severity of side effects may lead to poor adherence to therapy by patients. The use of sustained release formulations of minocycline that display slow dissolution of minocycline following administration may be beneficial in reducing the incidence and severity of side effects. Therefore, sustained release capsule dosage forms containing 100 mg minocycline (base) were manufactured and assessed for use as sustained release oral dosage forms of

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20

Mwila, Chiluba. "The development and assessment of sustained release nevirapine tablets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/54667.

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The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is

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21

Zindove, Chiedza Cathrine. "Development and assessment of sustained release stavudine loaded microparticles." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/54722.

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Stavudine (D4T) has been used as first line treatment for HIV/AIDS and is part of highly active anti retroviral treatment (HAART). It is an affordable medicine and its use is beneficial in resource limited settings. However D4T exhibits dose dependent side effects that may lead to non-adherence in patients. This study was undertaken to formulate, develop and manufacture a dosage form that could reduce dose dependent side effects by decreasing the dose of D4T but still exhibit antiretroviral (ARV) activity. The use of sustained release (SR) formulations of D4T that ensure constant levels of the

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22

Kao, Chen-Yu. "Developing a Minimally Invasive Sustained Release System for Glioma Therapy." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19757.

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Malignant brain tumor is one of the most lethal forms of cancers. In the United States alone, approximately 20,500 new cases of primary malignant brain and central nervous system tumors are expected to be diagnosed in 2007 with 12,740 deaths estimated. Treatment of malignant brain tumor remains a major challenge despite recent advance in surgery and other adjuvant therapies, such as chemotherapy. The failure of potential effective chemotherapeutics for brain tumor treatment is usually not due to the lack of potency of the drug, but rather can be attributed to lack of therapeutic strategies ca

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23

Makan, Anjana. "Development and assessment of gastric-retentive sustained release metronidazole microcapsules." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/59240.

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24

Oridota, Omoyosola Omolola. "Development and assessment of gastroretentive sustained release captopril micro-balloons." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63491.

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25

Rodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.

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26

Lewis, Karen Jane. "Biodegradable polymers for the sustained release of antisense nucleic acids." Thesis, Aston University, 1996. http://publications.aston.ac.uk/11054/.

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Antisense oligodeoxynucleotides can selectively inhibit individual gene expression provided they remain stable at the target site for a sufficient period of time. Thus, the efficacy of antisense oligodeoxynucleotides may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for the oligodeoxynucleotides and ribozymes. Polymers such as polylactide, polyglycolide, polyhydroxybutyr

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27

Akanda, Md Mushfiq Hossain. "Development of solid lipid nanoparticles for sustained release of anticancer agents." Thesis, University of Greenwich, 2015. http://gala.gre.ac.uk/18135/.

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A brief introduction to solid lipid nanoparticles (SLN) is provided and the reasoning behind the use of SLN over other colloidal carriers, such as emulsions and liposomes, are discussed. SLN has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased bioavailability of drug and lower overall cost. Techniques for the production of SLN, drug incorporation, loading capacity and drug release mechanisms are reviewed. The potential of SLN in anti-cancer drug delivery systems is highlighted. SLN formulations of two different lipids (tristearin, stearic acid), used

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28

Takemoto, Satoru. "Preparation of collagen/gelatin sponge scaffold for sustained release of bFGF." Kyoto University, 2008. http://hdl.handle.net/2433/135869.

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29

RAJBHANDARI, SANGITA. "THE EFFECTS OF POLYMER BLENDS ON THE RELEASE OF PROPRANOLOL HYDROCHLORIDE." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1005161908.

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30

Pokorný, Martin. "Návrh a realizace filtru ADSR." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-218044.

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The master´s thesis is focused on design of ADSR filter and voltage controlled amplifier (VCA). Three additional circuits performing analog signal processing are added. Functionality of designed circuits is verified in simulation program. All designed circuits are practically realized. Thesis includes complete design of the mentioned circuits and all necessary informations for its practical realization. All designed circuits are measured and the results are presented.

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31

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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32

Mcconville, C. M. C. "Development of silicone customer delivery systems for sustained release of HIV microbicides." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517358.

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33

Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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34

Carlier, Emeric. "Development of 3D printed implants for subcutaneous administration of sustained-release antibodies." Doctoral thesis, Universite Libre de Bruxelles, 2021. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326756.

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Thèse réalisée dans le cadre d'une collaboration avec UCB Pharma et la région Wallonne s'inscrivant dans le cadre du projet SAS. Le but de ce projet était de développer des implants sous-cutanés imprimés en trois dimensions pour permettre une libération d’anticorps thérapeutique de manière prolongée au cours du temps. En effet, les thérapies disponibles sont souvent administrées par voie intraveineuse, ce qui peut réduire la compliance des patients dû à l’inconfort et à la fréquence de ces administrations. Les systèmes de délivrance, tels que des implants, peuvent limiter les fréquences d’admi

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35

Esaki, Jiro. "Local sustained release of prostaglandin E1 induces neovascularization in murine hindlimb ischemia." Kyoto University, 2010. http://hdl.handle.net/2433/97947.

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36

McLellan, Bradley John. "Development of an Intraruminal Controlled-Release Device." The University of Waikato, 2007. http://hdl.handle.net/10289/2527.

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Slow-release devices retained in the rumen, are a simple method for continuous administration of bioactives to ruminant animals. To satisfy regulatory requirements and avoid waste of bioactive due to under- or over-dosing, it is advantageous to have a constant and predictable release rate. Existing intraruminal controlled-release technologies cannot easily be adapted for different bioactives or rates of release and can be influenced by the variable physiological environment in the rumen. Some existing commercial products use the pressure generated by a hydrogen gas-producing cell to extrude

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37

Ito, Ran. "Adipogenesis using human adipose tissue-derived stem cells sustaining release of basic fibroblast growth factor." Kyoto University, 2014. http://hdl.handle.net/2433/188645.

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38

Janoria, Kumar Gaurav Mitra Ashim K. "Transporter targeted prodrug approach and sustained release formulations for ocular delivery of ganciclovir." Diss., UMK access, 2008.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2008.<br>"A dissertation in pharmaceutical sciences and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed Sept. 12, 2008; title from "catalog record" of the print edition. Includes bibliographical references (leaves 193-204). Online version of the print edition.

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39

Hildebrandt, Christian. "Crystalline Monoclonal Antibodies: Development of stable crystals for drying and sustained release formulations." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-174392.

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40

Hodsdon, Alison Claire. "Xanthan gum and sodium alginate as sustained-release carriers in hydrophilic matrix tablets." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259859.

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41

Lee, K. V. "Optimisation and analysis of sustained release drug delivery systems to treat ocular disease." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400532/.

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Transscleral drug delivery has been a moreviable alternative drug delivery route to the posterior segment than other more invasive methods. The drug absorption involves passing through several layers of tissue, including the sclera and retinal pigment epithelium (RPE), to reach the retina. Posterior scleral thickness in both humans and normal C57BL/6 mice decreases with age. Lipofuscin density in albino mice’s eyes were two-fold higher than in pigmented mice and the drug-binding to these pigments could affect drug bioavailability. Drug molecular weight didn’t correlate with penetration efficie

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42

Marquette, Sarah. "Stabilization and development of sustained-release formulations of protein/antibody for subcutaneous delivery." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209251.

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ABSTRACT<p><p>This project aimed at developing a drug delivery system (DDS) able to enhance the stability and<p>residence time in vivo of antibodies (Abs). The system will deliver drug by the subcutaneous<p>route (SC), while ensuring accurate control of the drug release and the resulting plasmatic level. This technology platform will allow to reduce frequency of injection, potentially decrease side effects and maintain high concentration of Abs which will improve life of patient having chronic disease such as autoimmune and inflammatory disease. Biodegradable synthetic polymer-based formulatio

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43

Treki, Mahmud Sighayer. "Formulation and evaluation of propylene glycol monostearate microspheres for sustained release of nitrofurantoin." Scholarly Commons, 1988. https://scholarlycommons.pacific.edu/uop_etds/3366.

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Sustained release of nitrofurantoin (NFT) from microspheres of propylene glycol monostearate (PGM) and of PGM and ethoxylated stearyl alcohol (ESA) prepared by the meltable dispersion and cooling process was investigated. The microspheres (30-850 mu) were nonsticky, discrete and free flowing. Both the rate and extent of in vitro release of NFT (from NFT-PGM microspheres in distilled water at 37 degrees C under constant agitation at 50 rpm) declined with decreasing NFT/PGM ratio. The effect of incorporating ESA over the range of 0.01 to 0.05% w/w of PGM in formulations with NFT/PGM ratios of 1:

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44

Manna, Soumyarwit. "Sustained Release Micro-implants for Delivery of Hydrophilic Drugs to Treat Vitreoretinal Diseases." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1471346005.

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45

Himmelheber, Anne Marie. "Cortical acetylcholine release during sustained attentional and non-attentional operant performance in rats /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488199501406727.

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46

Lin, Xue. "Sustained-release erythropoietin ameliorates cardiac function in rat infarct heart without inducing polycythemia." Kyoto University, 2007. http://hdl.handle.net/2433/135721.

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47

Hirose, Keiichi. "Sustained-release form of basic fibroblast growth factor prevents catheter-related bacterial invasion." Kyoto University, 2006. http://hdl.handle.net/2433/143820.

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48

Zhang, Feng. "Hot-melt extrusion as a novel technology to prepare sustained-release dosage forms /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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49

Li, Anqi. "Injectable hydrogels for controlled and sustained local drug delivery." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ014.

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Les hydrogels injectables sont largement explorés en tant que réservoirs pour une administration locale de substances actives (SA) afin d'en augmenter la biodisponibilité et réduire la toxicité systémique. En oncologie, une telle approche peut être particulièrement pertinent par exemple dans le traitement de la carcinose péritonéale pour laquelle le protocole thérapeutique standard repose sur une chirurgie cytoréductive suivie de l'administration intrapéritonéale (IP) d'une thermo-chimiothérapie (HIPEC). Cependant, les SA administrés par voie intrapéritonéale ont un temps de résidence court en

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50

Tian, Weiwei. "The Development of Sustained Release Formulation for Pharmaceutical Proteins based on Vesicular Phospholipid Gels." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-117275.

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