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Dissertations / Theses on the topic 'Sustained-release drug delivery'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid

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2

Wilding, Ian Robert. "Some studies of oral sustained release of pellet systems." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319343.

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3

Rodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.

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4

Zhang, Feng. "Hot-melt extrusion as a novel technology to prepare sustained-release dosage forms /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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5

Awang, Mohamed Bin. "Radiolabelling of pharmaceutical dosage forms by neutron activation of Samarium-152." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261026.

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6

Hodsdon, Alison Claire. "Xanthan gum and sodium alginate as sustained-release carriers in hydrophilic matrix tablets." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259859.

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7

Lee, K. V. "Optimisation and analysis of sustained release drug delivery systems to treat ocular disease." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400532/.

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Transscleral drug delivery has been a moreviable alternative drug delivery route to the posterior segment than other more invasive methods. The drug absorption involves passing through several layers of tissue, including the sclera and retinal pigment epithelium (RPE), to reach the retina. Posterior scleral thickness in both humans and normal C57BL/6 mice decreases with age. Lipofuscin density in albino mice’s eyes were two-fold higher than in pigmented mice and the drug-binding to these pigments could affect drug bioavailability. Drug molecular weight didn’t correlate with penetration efficie

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8

Avgoustakis, Konstantine. "Synthesis and evaluation of some poly(lactide-co-glycolides) for use in sustained release tablets." Thesis, King's College London (University of London), 1992. https://kclpure.kcl.ac.uk/portal/en/theses/synthesis-and-evaluation-of-some-polylactidecoglycolides-for-use-in-sustained-release-tablets(8b664ccc-71de-4a1c-8995-7b7f9c72e905).html.

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9

Chopra, Poonam. "Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353951512.

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10

Manna, Soumyarwit. "Sustained Release Micro-implants for Delivery of Hydrophilic Drugs to Treat Vitreoretinal Diseases." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1471346005.

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11

Marquette, Sarah. "Stabilization and development of sustained-release formulations of protein/antibody for subcutaneous delivery." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209251.

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ABSTRACT<p><p>This project aimed at developing a drug delivery system (DDS) able to enhance the stability and<p>residence time in vivo of antibodies (Abs). The system will deliver drug by the subcutaneous<p>route (SC), while ensuring accurate control of the drug release and the resulting plasmatic level. This technology platform will allow to reduce frequency of injection, potentially decrease side effects and maintain high concentration of Abs which will improve life of patient having chronic disease such as autoimmune and inflammatory disease. Biodegradable synthetic polymer-based formulatio

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12

MODICA, DE MOHAC Laura. "Novel Drug Delivery System for Treatment-Resistant Schizophrenia." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/478483.

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13

Carlier, Emeric. "Development of 3D printed implants for subcutaneous administration of sustained-release antibodies." Doctoral thesis, Universite Libre de Bruxelles, 2021. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/326756.

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Thèse réalisée dans le cadre d'une collaboration avec UCB Pharma et la région Wallonne s'inscrivant dans le cadre du projet SAS. Le but de ce projet était de développer des implants sous-cutanés imprimés en trois dimensions pour permettre une libération d’anticorps thérapeutique de manière prolongée au cours du temps. En effet, les thérapies disponibles sont souvent administrées par voie intraveineuse, ce qui peut réduire la compliance des patients dû à l’inconfort et à la fréquence de ces administrations. Les systèmes de délivrance, tels que des implants, peuvent limiter les fréquences d’admi

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14

Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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15

Cantin, Oriane. "PEO hot melt extrudates for controlled drug delivery." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S035/document.

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Parmi les procédés de fabrication continue, l’extrusion par fusion à chaud est une technique dont l’intérêt dans le domaine pharmaceutique est grandissant. Ce procédé permet la formation des dispersions solides des substances actives au sein des matrices polymériques ou lipidiques. En fonction de l’excipient et de la substance active, cela peut être largement utilisé pour la conception des systèmes: (i) pour une libération immédiate, (ii) pour une libération modifiée et (iii) pour le masquage de goût. Les systèmes à libération modifiée sont des dispositifs intéressants qui permettent d’amélior

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16

Motoyuki, Kumagai. "A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model." Kyoto University, 2019. http://hdl.handle.net/2433/245294.

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17

Kao, Chen-Yu. "Local and sustained delivery of hydrophobic drugs to the spinal cord with polyketal microparticles." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37304.

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Amyotrophic lateral sclerosis (ALS) is a devastating disease. Currently, there is no cure for this disease, and effective treatment strategies are greatly needed. Calpain activation plays a major role in the motor neuron degeneration that causes ALS. Therefore, therapeutic strategies can inhibit calpain activity in the central nervous system (CNS) have great clinical potential. The calpain inhibitors AK295 and MDL-28170 have been demonstrated to be neuroprotective in animal models of neurological injury, and should have great potential to treat ALS; however delivery problems have hindered t

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18

Holden, Christopher A. "MODIFIED PAMAM DENDRIMERS IN TUNABLE DRUG-DELIVERY SYSTEMS: A SUSTAINED-RELEASE DENDRIMER HYDROGEL FOR ANTI-GLAUCOMA DRUGS AND SURFACE-ENGINEERED MACROPHAGES AS NANOPARTICLE CARRIERS FOR TARGETED ANTI-CANCER THERAPY." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5038.

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Two specific drug-delivery applications were sought in this work using polyamidoamine (PAMAM) dendrimers. One drug-delivery system used a novel dendrimer hydrogel (DH) for sustained delivery of anti-glaucoma drugs. In this work, PAMAM G3.0 dendrimers were covalently bonded with poly(ethylene glycol) (PEG12000) molecules which were subsequently acrylated, resulting in photocurable DH conjugates. For pharmacological studies, DH were loaded with a solution of intraocular pressure lowering drugs, brimonidine and timolol maleate, and were characterized for in vitro release and ex vivo transport an

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19

Hasa, Dritan. "Innovative systems for drug delivery: pharmacokinetic and technological aspects." Doctoral thesis, Università degli studi di Trieste, 1985. http://hdl.handle.net/10077/9503.

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2011/2012<br>Nowadays, the main objective of pharmaceutical companies is to develop innovative oral dosage forms for both prolonged and immediate drug releases. In fact, oral delivery has the peculiar advantage of being highly versatile dosage-wise. However, actives suffering from low oral bioavailability may not always be administered by using traditional dosage forms or common controlled release devices, due to the bioavailability’s strict dependence on both drug solubility in gastrointestinal fluids and on drug permeability through the cellular membranes. Recently, both conventional and mo

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20

Vay, Kerstin. "Analysis and control of the manufacturing process and the release properties of PLGA microparticles for sustained delivery of a poorly water-soluble drug." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-150495.

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21

Santos, Cayane Genro. "DESENVOLVIMENTO E CARACTERIZAÇÃO DE UMA NOVA BLENDA POLIMÉRICA DE POLI(METIL METACRILATO)-POLI(ETILENOGLICOL) PARA PRODUÇÃO DE NANOCÁPSULAS E APLICAÇÃO EM DRUG DELIVERY." Centro Universitário Franciscano, 2017. http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/573.

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Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-20T12:23:08Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_CayaneGenroSantos.pdf: 3426105 bytes, checksum: 7a9b15fe21608009c9d6ca592e708bf4 (MD5)<br>Made available in DSpace on 2018-08-20T12:23:08Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_CayaneGenroSantos.pdf: 3426105 bytes, checksum: 7a9b15fe21608009c9d6ca592e708bf4 (MD5) Previous issue date: 2017-03-20<br>Polymers are part of our life and have many applications in d

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22

Giacalone, Giovanna. "Implant chargé en nanoparticules pour la libération contrôlée et le ciblage lymphatique de nucléotides et d’analogues nucléotidiques." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114845.

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Les nucléotides naturels et les analogues nucléotidiques présentent des activités pharmacologiques importantes : par exemple, le nucléotide adénosine triphosphate (ATP) présente un intérêt pour le traitement de l'ischémie ou de plaques d'athérosclérose. L'utilisation clinique de ces molécules est cependant limitée en raison de la présence d'un groupe triphosphate, qui est sujet à l'hydrolyse in vivo, et responsable de la forte hydrophilie des molécules, ce qui limite fortement leur capture par les cellules cibles et l'accès à leurs cibles pharmacologiques intracellulaires. Pour surmonter ces l

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23

Ditto, Andrew James. "Biodegradable Nanoparticles for Use as an Inhalable Antimicrobial and as a Receptor Targeted Delivery Device." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1280335303.

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24

Li, Zipeng. "Sustained-release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model." Kyoto University, 2018. http://hdl.handle.net/2433/235987.

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25

Reeff, Jonathan. "Development and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209288.

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Future changes in the incidence and prevalence of OA are difficult to predict. As incidence and prevalence rise with increasing age, extending life expectancy will result in greater numbers with OA. Actually, usual therapeutic approaches are really restricted because of important side effects with long-term use. Therefore, there is a need to develop improved formulations which are well tolerated, biocompatible and biodegradable. Ideally, these new treatments should be able to deliver locally sufficient amount of anti-inflammatory or analgesic drugs into the site of arthritic inflammation while

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26

Vay, Kerstin [Verfasser], and Wolfgang [Akademischer Betreuer] Frieß. "Analysis and control of the manufacturing process and the release properties of PLGA microparticles for sustained delivery of a poorly water-soluble drug / Kerstin Vay. Betreuer: Wolfgang Frieß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1029040303/34.

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27

Li, Anqi. "Injectable hydrogels for controlled and sustained local drug delivery." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ014.

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Les hydrogels injectables sont largement explorés en tant que réservoirs pour une administration locale de substances actives (SA) afin d'en augmenter la biodisponibilité et réduire la toxicité systémique. En oncologie, une telle approche peut être particulièrement pertinent par exemple dans le traitement de la carcinose péritonéale pour laquelle le protocole thérapeutique standard repose sur une chirurgie cytoréductive suivie de l'administration intrapéritonéale (IP) d'une thermo-chimiothérapie (HIPEC). Cependant, les SA administrés par voie intrapéritonéale ont un temps de résidence court en

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28

Polexe, Ramona Cristina. "Développement et caractérisation de nouveaux systèmes hybrides inorganique/organique pour la formulation de principes actifs." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20144/document.

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Le sujet de cette thèse consiste à formuler et caractériser de nouveaux matériaux hybrides inorganique/organique pour la formulation et la libération de principes actifs. Ces matériaux sont constitués soit par des hydroxydes doubles lamellaires (HDL) et des phospholipides (PL) soit par des hydroxydes doubles lamellaires et du chitosane. Les matériaux hybrides hydroxydes doubles lamellaires/phospholipides ont été obtenus par échange anionique entre les anions du feuillet d'HDL et les phospholipides chargés négativement sous forme de liposomes. Les techniques d'analyse utilisées (DRX, ATG, UV et

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29

Ongkasin, Kanjana. "Elaboration de dispositifs médicaux ophtalmiques à libération contrôlée de médicaments par imprégnation supercritique." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0536.

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Les technologies utilisant le CO2 supercritique sont considérées comme des alternatives vertes et éco-responsables pour la formulation de médicaments et le traitement de dispositifs médicaux. Ce travail de thèse a pour objectif de développer des dispositifs médicaux ophtalmiques innovants pour prévenir deux complications postopératoires de la chirurgie de la cataracte, l’endophtalmie et l’opacification de la capsule postérieure. Parmi d'autres procédés, l'imprégnation supercritique a été sélectionnée pour incorporer des principes actifs ophtalmiques dans des implants intraoculaires (IOLs) disp

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30

Solfiell, David J. "Gold Nanoparticles and Drug Delivery." 2014. https://scholarworks.umass.edu/theses/1200.

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Nanoparticles are important tools in biotechnology and biomedical research. Gold nanoparticles (AuNPs) have emerged as a particularly important class of nanobiotechnological tools as a result of a number of unique and useful attributes. These attributes include the high degree of biocompatibility of AuNP cores, the similarity in size of AuNPs and biomacromolecules, and the great chemical flexibility of AuNP surface design. One of the most promising applications of AuNPs in biotechnology and biomedicine is their use as drug delivery vehicles. Drug delivery vehicles provide therapeutics with des

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31

Li, Yun-Ru, and 李昀儒. "Sustained Release of Cisplatin from Drug Delivery System Based on PCL Membrane." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/36140703009868805946.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>104<br>To develop a sustained drug delivery system based on PCL membrane, promoting pleural adhesion, for the treatment of malignant pleural effusion (MPE), cisplatin (CDDP)-encapsulated PLGA nanoparticles (PLGA/CDDP NPs) were fabricated via solvent displacement method for the purpose of prolonging drug delivery. The PCL membrane incorporating CDDP and PLGA/CDDP NPs (PLGA/CDDP NP-PCL/CDDP membrane) was investigated under the in vitro and in vivo conditions with the comparison of PCL membrane incorporating CDDP (PCL/CDDP membrane) and free CDDP in solution form. As n

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32

Sinclair, Steven Michael. "Development of Depot Forming Elastin-Like Polypeptide-Curcumin Drug Conjugates for Sustained Drug Delivery to Treat Neuroinflammatory Pathologies." Diss., 2013. http://hdl.handle.net/10161/7175.

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<p>Neuroinflammation associated with lumbar radiculopathy and peripheral nerve injury is characterized by locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration of TNF antagonists for radiculopathy in the clinic has shown mixed results, and there is growing interest in local delivery of anti-inflammatory drugs to treat this pathology, as well as similar inflammatory events of peripheral nerve injury. Curcumin, a known antagonist of TNFα in multiple cell types and tissues, was chemically modified and conjugated to a the

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33

Yu-PuChu та 朱育普. "Sustained release of antibiotic from bioactive micro arc oxidized TiO2 using γ-PGA for drug delivery". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/whw8y3.

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34

Rakkanka, Vipaporn. "A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet." Thesis, 2003. http://hdl.handle.net/1957/30894.

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35

Stanwick, Jason. "Enhanced Bioactivity and Sustained Release of NT-3 and Anti-NogoA from a Polymeric Drug Delivery System for Treatment of Spinal Cord Injury." Thesis, 2012. http://hdl.handle.net/1807/33769.

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Neurotrophin-3 (NT-3) and anti-NogoA have shown promise in regenerative strategies after spinal cord injury; however, conventional methods for localized release to the injured spinal cord are either prone to infection or not suitable for sustained release. To address these issues, we have designed a composite drug delivery system that is comprised of poly(lactic-co-glycolic acid) (PLGA) nanoparticles dispersed in an injectable hydrogel of hyaluronan and methyl cellulose (HAMC). Achieving sustained and bioactive protein release from PLGA particles is a known challenge; consequently, we studied

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36

Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.

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Les amidons non modifiées et modifiés représentent un groupe d’excipients biodégradables et abondants particulièrement intéressant. Ils ont été largement utilisés en tant qu’excipients à des fins diverses dans des formulations de comprimés, tels que liants et/ou agents de délitement. Le carboxyméthylamidon sodique à haute teneur en amylose atomisé (SD HASCA) a été récemment proposé comme un excipient hydrophile à libération prolongée innovant dans les formes posologiques orales solides. Le carboxyméthylamidon sodique à haute teneur en amylose amorphe (HASCA) a d'abord été produit par l'éthérif

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37

Yan, Liang. "Studies of self-assembled substituted poly(acrylate) networks as potential sustained drug delivery systems and of fluorescent conjugated polymer nanoparticles in cell imaging." Thesis, 2016. http://hdl.handle.net/2440/103611.

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Polymer networks are promising biomaterials for drug delivery as they have porous structures and are often biocompatible. The general aspects of the host-guest complexation capability of polymer networks containing cyclodextrins as well as their application in drug delivery are considered in Chapter 1. The introduction of cyclodextrins into polymer networks has the potential to improve drug loading capacity and modulate subsequent drug release behavior due to the host-guest complexation by cyclodextrins of drug molecules. Thus, Chapter 2 and Chapter 3 are concerned with new research on water s

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38

Son, Yoen Ju. "Dry powder antibiotics for inhaled anti-tuberculosis therapy." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-12-2230.

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The aim of this research was to develop and fully investigate a novel method of antibiotic drug delivery to the lung that will address problems with current therapeutic regimens for treatment of airway infections. To demonstrate the performance of prepared formulations, the design of suitable characterization methods were also aimed. A novel dissolution method for evaluating the in vitro dissolution behavior of inhalation formulations was developed. The membrane holder was designed to enclose previously air-classified formulations so that they could be uniformly tested in the dissolution appar

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39

Pham, Loan. "1) Preparation of acetaminophen capsules containing beads prepared by hot-melt direct blend coating method 2) Pharmacokinetic modeling and Monte Carlo simulations in context of additional criteria for bioequivalence assessments 3) Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy." Thesis, 2012. http://hdl.handle.net/1957/29715.

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The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the formulation based on the PK of the drug. Hot-melt coating using a new method, direct blending, was performed to create immediate and sustained release formulations (IR and SR). This new method was introduced to offer another choice to produce IR and SR drug delivery formulations using single and doub

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40

Conte, Claudia. "CORE-SHELL SUSTAINED RELEASE NANOSYSTEMS FOR THE INTRAVENOUS DELIVERY OF ANTICANCER DRUGS." Tesi di dottorato, 2013. http://www.fedoa.unina.it/9407/1/conte%20claudia.pdf.

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In the last few years, an increased interest is being focused on the development of sustained release nanocarriers pointing to their possible application as intravenous nanomedicines with better performance and lower toxicity as compared to free drugs. We designed and tested several core-shell nanocapsules and nanoparticles (NPs), for the intravenous delivery of both hydrophilic and lipophilic drugs respectively. As base materials, we employed biodegradable amphiphilic block copolymers of poly(-caprolactone) (PCL) and poly(ethyleneoxide) (PEO) with different architectures. In the first stag

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Grant, David William. "Reduced Burst Release of Bioactive rhBMP-2 from a Three-phase Composite Scaffold." Thesis, 2010. http://hdl.handle.net/1807/25605.

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Recombinant human bone morphogenic proteins (rhBMPs) are extensively studied and employed clinically for treatment of various bone defects. Current clinical delivery vehicles suffer wasteful burst releases that mandate supra-physiological dosing driving concerns over safety and cost. It was therefore investigated whether a unique drug delivery vehicle sequestered within a composite scaffold could lower the burst release of rhBMP-2. PLGA-calcium phosphate tri-phasic composite scaffolds delivered model protein BSA with burst release of ~13% and sustained kinetics of 0.5-1.5% BSA/day up to 45 day

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