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Journal articles on the topic 'Sustained-release drug delivery'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Mandhar, Piyush, and Gayitri Joshi. "Development of Sustained Release Drug Delivery System: A Review." Asian Pacific Journal of Health Sciences 2, no. 1 (2015): 179–85. http://dx.doi.org/10.21276/apjhs.2015.2.1.31.

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BHADORIYA, ABHILASHA, and TRUPTI SHUKLA. "A CONCISE REVIEW ON SPANSULES: A NEW METHOD OF DRUG DELIVERY." Current Research in Pharmaceutical Sciences 13, no. 1 (2023): 21–26. http://dx.doi.org/10.24092/crps.2023.130102.

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Spansules are considered as an Advanced Drug Delivery System because they allow for controlled and sustained release of medication over an extended period of time. This type of delivery system can provide a constant plasma drug concentration over a wide range of time, which can improve treatment outcomes and reduce the risk of side effects. In addition to providing sustained release, Spansules can also be used to deliver multiple drugs in a single dosage form. The multi-drug regimen capability of Spansules is also beneficial, as it allows for the delivery of multiple drugs in a single dosage f

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Menkudale, Amruta, Pankaj Khuspe, Kishor Otari, Manisha Khemnar, and Vaishali Kulkarni. "An Updated Review on Applications of Natural Polymers in Sustained Release Drug Delivery System." Journal of Advances in Pharmacy Practices (e-ISSN: 2582-4465) 2, no. 1 (2020): 45–49. https://doi.org/10.5281/zenodo.3674633.

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<em>Sustained release drug delivery system is area of interest for formulation scientists in pharmaceutical industry because of advantage of administering a single dose of a drug that is released for an extended period of time instead of numerous doses. SDDS have various advantages like it optimize biopharmaceutical, pharmacokinetic and pharmacodynamic properties of drug in order to increase its use, reduce adverse effects, cure the disease, decrease the frequency of administration and thus, increase the patient compliance, increase safety margin of potent drugs, reduce healthcare costs etc. T

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4

Ankit, Singh* Rajesh Gour** &. Akhlesh Kumar Singhai***. "MODIFIED RELEASE OF MEDICATION DELIVERY: A REVIEW." International Journal of Scientific Research and Modern Education (IJSRME) 8, no. 1 (2023): 33–41. https://doi.org/10.5281/zenodo.7806086.

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In terms of drug delivery methods, the oral route is the most popular. However, the traditional dosage form has a few drawbacks that could be fixed by altering the current dosage form. A regulated and sustained drug delivery system prolongs the duration of action by slowing the drug's release rate and maintaining a consistent plasma drug concentration. The matrix tablet is a crucial tool among the numerous formulation options for sustained release tablets. This makes issues like poor patient compliance, multiple doses, and see-saw oscillations simply manageable. A number of hydrophilic or

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Muni, Raja Lakshmi K* Naseema Shaik Lavanya E. Venkata Rao Gadde. "Formulation And Evaluation of Sustained Release Matrix Tablets – A Review." Int. J. in Pharm. Sci. 1, no. 7 (2023): 170–81. https://doi.org/10.5281/zenodo.8114751.

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Oral drug delivery is still the finest and most popular method for administering pharmaceuticals via the internal route. Sustained release is also a good option for reducing adverse effect of drugs and boosting its therapeutic potency. The fundamental ideas of sustained drug delivery system optimise a variety of factors, such as a drugs pharmaceutical, pharmacokinetic and pharmacodynamic properties in order to increase therapeutic efficacy, minimise side effects and make disease cure simple. The major goal of this review is to provide comprehensive information about sustained release dose and

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Rajput, Rajesh, K. M. K. Prasanna Kumar, D. S. Arya, et al. "Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care." International Journal of Research in Medical Sciences 9, no. 1 (2020): 303. http://dx.doi.org/10.18203/2320-6012.ijrms20205861.

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Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled m

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Prajapat, Priyanka, Dilip Agrawal, and Gaurav Bhaduka. "A brief overview of sustained released drug delivery system." Journal of Applied Pharmaceutical Research 10, no. 3 (2022): 05–11. http://dx.doi.org/10.18231/j.joapr.2022.10.3.5.11.

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The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated

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Sonali, S. Sonawane* Vikas B. Wamne. "A Review On : Sustained Release Oral Drug Delivery System." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 771–83. https://doi.org/10.5281/zenodo.10401318.

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Oral drug delivery is the most preferred and convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets & capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent  undesirable toxicity and poor efficiency. The maintenance of concentration of drug

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Vigneshwaran, LV, Abdullakunhi Thasneem, Irfana BM Fathimath, PV Thushara, Sebastin V., and Babu TK Ajith. "DERMAL DRUG DELIVERY THROUGH NANOCARRIERS." World Journal of Pharmaceutical Science and Research 2, no. 4 (2023): 25–28. https://doi.org/10.5281/zenodo.10897614.

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Nanocarriers have been explored for delivering drugs and other bioactive molecules for well over 35years. Since the introduction of a nanoliposomal delivery system for the cancer drug doxorubicin, several products have been approved worldwide. The majority of these products focus on cancer chemotherapy, and utilize the size advantage of nanocarriers to obtain a favourable distribution of the drug carrier in the human body. In general, such carriers do not sustain drug release over more than a few days at best. A variety of nanocarriers have been studied, and their advantages and shortcomings a

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Jyoti, Gupta Hans Raj* Divya. "Emerging Frontiers In Sustained Release Drug Delivery Systems: Unveiling The Latest Innovations And Future Perspectives." International Journal in Pharmaceutical Sciences 1, no. 2 (2023): 186–206. https://doi.org/10.5281/zenodo.8267084.

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Sustained release drug delivery systems have emerged as a promising approach to improve therapeutic effectiveness and patient compliance. This review article aims to provide a comprehensive overview of the advancements in sustained release drug delivery systems, focusing on design principles, formulation strategies, and novel approaches. The introduction highlights the background and significance of sustained release drug delivery systems in optimizing therapy for chronic conditions. The objectives of the review article include exploring the factors influencing system design, considering patie

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Anjali, Bagmar, and Tikariya Komal. "SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: AN OVERVIEW." International Journal of Pharmaceutical Sciences and Medicine 6, no. 9 (2021): 79–87. http://dx.doi.org/10.47760/ijpsm.2021.v06i09.006.

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Oral delivery of drugs is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc. Sustained release constitutes are the dosage form that provides medication over an extended time or denotes that the system is able to provide some actual therapeutic control whether this is of a temporal nature, spatial nature or both. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance del

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Chetan, Patil* Rohini Patil Ajit Patil. "A Comprehensive Review of Matrix Tablets and Assessment Techniques." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1047–57. https://doi.org/10.5281/zenodo.15014891.

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Matrix with sustained release tablets have changed the way of drug delivery by exhibiting controlled release of drugs, increasing therapeutic effect, and improving compliance of the patient. The systems decrease frequency of dosing, reduce side effects, and provide stable drug levels in the body, which are a mainstay of contemporary pharmaceutical science. This review provides an overview of the matrix tablets with regard to their classification into hydrophobic, hydrophilic, lipid, and biodegradable matrices, as well as mechanisms of drug release, viz diffusion, dissolution, and erosion. Vari

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Eisha, Ganju*¹ Rajni Dubey² Shaheen Shama³ Bhaskar Kumar Gupta⁴. "Microspheres as Novel Drug Delivery Advantages and Application: A Review." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1525–35. https://doi.org/10.5281/zenodo.15202876.

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Microspheres are innovative drug delivery systems that have gained significant attention in pharmaceutical and biomedical applications due to their ability to deliver therapeutic substances in a controlled and sustained manner. These microscopic, spherical particles, typically composed of biodegradable polymers and drugs, offer a variety of benefits, including improved drug solubility, extended release, and enhanced bioavailability. Microspheres are versatile, used in various fields such as vaccine delivery, controlled drug release, and diagnostic purposes. Their small particle size, ranging f

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Mangesh, Dagale* Dr. Nilesh Gorde Kartik Shinde Ashwini Karnakoti Prajwal Birajdar. "Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review." International Journal of Scientific Research and Technology 2, no. 1 (2025): 266–76. https://doi.org/10.5281/zenodo.14678430.

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The development of sustained release (SR) matrix tablets has garnered significant attention in modern pharmaceutical research owing to their ability to maintain prolonged therapeutic action, improve patient compliance, and enhance drug bioavailability. Among various approaches for achieving sustained release, the use of natural gums as matrix-forming agents has emerged as a promising strategy due to their biocompatibility, biodegradability, non-toxicity, and economic viability. This review focuses on the formulation, evaluation, and applications of SR matrix tablets, with a special emphasis on

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Sarthak, Keluskar* Rachel Geevarghese Swapnil Phalak. "Nanoparticles Based Sustained Release Tablets: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4615–24. https://doi.org/10.5281/zenodo.15538501.

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Nanoparticle-based sustained release tablets represent a transformative advancement in the field of pharmaceutical technology, offering numerous benefits over conventional drug delivery systems. These formulations are designed to release therapeutic agents at a controlled rate over an extended period, thereby improving drug bioavailability, reducing dosing frequency, and enhancing patient adherence. By incorporating drugs into nanoparticles, it is possible to modify pharmacokinetic profiles, ensure consistent plasma drug levels, and minimize peak-trough fluctuations, which can lead to adverse

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Manish, Kumar Gupta, Ghadge Madhvi, Verma Sunil, and Singh Sudharshana. "FORMULATION AND EVALUATION OF BILAYER TABLETS FOR SUSTAINED RELEASE." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 38–43. https://doi.org/10.5281/zenodo.12667170.

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Bi-layer tablet is a new era for successful development of controlled release formulationalong with various features to provide successful drug delivery. Bilayer layer tablets consistof two layers which are slow release and immediate release layers. It is an improvedtechnology to overcome the shortcoming of the single layer tablets and offer more benefits.The bilayer tablet helps to separate incompatible active pharmaceutical ingredient (APIs)from each other. Bilayer tablets material involves both the compressibility and consolidation.Bilayer formulations carry different drugs in each layer an

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Farhana, M. K.*1 Junise V. 2. Hasna E. K.3 Shilpa K. D.4. "Review On In-Situ Gel: A Novel Approach To Sustained And Controlled Release Form." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1318–25. https://doi.org/10.5281/zenodo.12763331.

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The ‘in situ gel’ system can be used to deliver both controlled and sustained delivery of drug. Due to its special feature of ‘Sol to Gel transition’ it is widely accepted as a novel drug delivery system with improved patient compliance. The sol to gel transition occurs at various physiological conditions thereby provide sustained drug release. The various polymers helps in this transition at targeted site. The ‘in situ gel’ has a wider application in ocular, oral, rectal, vaginal, nasal, transdermal delivery of drugs.

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Benson, Heather AE, and Richard J. Prankerd. "Optimisation of Drug Delivery 3. Sustained/Controlled-Release Oral Drug Delivery." Australian Journal of Hospital Pharmacy 27, no. 5 (1997): 381–89. http://dx.doi.org/10.1002/jppr1997275381.

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19

Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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20

Hardy, John G., and Terence S. Chadwick. "Sustained Release Drug Delivery to the Lungs." Clinical Pharmacokinetics 39, no. 1 (2000): 1–4. http://dx.doi.org/10.2165/00003088-200039010-00001.

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21

Lowinger, Michael, Stephanie Barrett, Feng Zhang, and Robert Williams. "Sustained Release Drug Delivery Applications of Polyurethanes." Pharmaceutics 10, no. 2 (2018): 55. http://dx.doi.org/10.3390/pharmaceutics10020055.

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22

Lagarce, F., and J. P. Benoit. "Sustained release formulations for spinal drug delivery." Journal of Drug Delivery Science and Technology 14, no. 5 (2004): 331–43. http://dx.doi.org/10.1016/s1773-2247(04)50061-8.

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23

Mandhan, Rahul, and Twinkle Garg. "Sustained Release Matrix Technology for Cefixime- A Review." International Journal of Pharmaceutical Sciences and Medicine 7, no. 8 (2022): 10–19. http://dx.doi.org/10.47760/ijpsm.2022.v07i08.002.

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Sustained release drug delivery system is designed to sustain the release of the drug dosage forms at a predetermined rate. Sustained release formulation maintains uniform drug level in therapeutic window, improved efficacy of drug by localization at the site of action with better patient compliance, reducing the dose required, providing uniform drug delivery. The sustained release formulations minimize the frequency of drug administration and do not interfere with the therapeutic action of the drug. The use of sustained release matrix technology for antibiotics is effective in preventing the

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Uma, M* Nagaraja T.S Vitthal K. Vijapure Bharathi D.R. "DEVELOPMENT AND EVALUATION OF NIOSOMAL DRUG DELIVERY SYSTEM CONTAINING TRANEXAMIC ACID." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 13113–23. https://doi.org/10.5281/zenodo.3257978.

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<em>The present study aimed to optimize the drug delivery of tranexamic acid from the niosomes by using different grades of surfactants and cholesterol at different molar concentrations in order to achieve prolonged release time and sustained release. Tranexamic acid is one of the most effective anti</em><em>fibrinolytic drugs used in the treatment of fibrinolysis.</em><em> Niosomes are the novel vesicular drug delivery system by which we can achieve the constant plasma drug concentration for the extended period of time. The vesicles are prepared from nonionic surfactants and cholesterol by th

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Aesha, Matroja, Sneha Singh Miss., and Karunakar Shukla Dr. "Formulation and evaluation of microsphere of Dalbergia sisso and its antimicrobial activity." Pharmaceutical and Chemical Journal 10, no. 5 (2023): 18–44. https://doi.org/10.5281/zenodo.13997571.

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Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. These have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, so simulate controlled drag release. These microspheres are used for drug delivery, wherein the drug can be encapsulated or in entrapped form Polymeric microspheres are ideal vehicles for many controlled delivery applications due to their ability to encapsulate a variety of drugs, biocompatibility, high bioavailability and sustained drug release cha

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Santosh Kumar, Rada, and R. Renuka. "Isolation and Characterization of Moringa Olifera Gum: A Novel Sustained Release Polymer." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 484–86. http://dx.doi.org/10.22270/jddt.v9i3.2913.

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If one were to imagine the ideal drug delivery system, two prerequisites would be required. First, it would be a single dose for the duration of treatment, whether it will be for days or weeks, as with infection, or for the lifetime of the patient, as in hypertension or diabetis. Second, it should deliver the active entity directly to the site of action, thereby minimising or eliminating side effects. This may necessitate delivery to specific receptors or to localization to cells or to specific areas of the body. In the past decade great interest got generated on replacing conventional adminis

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Goyal, Sumit, Pranjali Dwivedi, Jaya Kaushik, Mayank Jhanwar, Ankita Singh, and Anushree C M. "Innovations in ocular drug delivery." Southeast Asian Journal of Health Professional 7, no. 3 (2024): 59–64. http://dx.doi.org/10.18231/j.sajhp.2024.015.

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Traditional ocular drug delivery methods via topical (eye drops and ointments) and systemic routes (oral or intravenous medications) yield suboptimal therapeutic drug concentrations intraocularly. Innovations aimed at improving the localization, duration, and efficacy of ocular drug delivery have shifted treatment paradigm by enhancing drug penetration, sustaining drug release and also enhancing patient compliance.:Aim of this review is to summarize recent advancements in ocular drug delivery systems, to evaluate their clinical effectiveness and to discuss their potential to improve clinical o

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S, Lakshmana Prabu. "A Typical Properties of Nanomaterials for Applications in Drug Delivery: A Review." Bioequivalence & Bioavailability International Journal 5, no. 2 (2021): 1–7. http://dx.doi.org/10.23880/beba-16000155.

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Developing a new drug molecule is an interdisciplinary research. A new drug molecule takes 10-14 years to develop with a 0.01% success rate. The developed new drug is administered as conventional or sustained release dosage forms. Among the conventional and sustained release dosage forms, sustained release form has many advantages. In the 21 st century, nanotechnology has become an innovative field and the nanomaterials/nanoparticles made by this technology had specific atypical properties. An extensive research interest among the researchers made a new revolution and its application almost in

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Prakash, Nathaniel Kumar Sarella, and Rama Krishna Pravallika Godavari Lakshmi. "The Expanding Scope of Emulgels: Formulation, Evaluation and Medical Uses." International Journal of Current Science Research and Review 06, no. 05 (2023): 3030–41. https://doi.org/10.5281/zenodo.7982582.

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<strong>ABSTRACT: </strong>Emulgels are semi-solid emulsions that combine the benefits of both emulsions and gels. They provide enhanced stability, sustained release and improved cosmetic properties. Emulgels can be fabricated using a variety of emulsification techniques and gelling agents like carbopol, hydroxypropyl cellulose. Characterization of emulgels includes evaluation of particle size, viscosity, pH, spreadability and drug release. Emulgels have promising applications in topical delivery of drugs and cosmetics, parenteral delivery of drugs and as emulsion-based oral drug delivery syst

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G. Ingle, Tushar Kumar, Shrikant D. Pande, Sandeep Atram, Nishant Bobade, and Vikrant Wankhede. "Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 36–45. http://dx.doi.org/10.22270/ajprd.v11i4.1283.

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The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriat

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Ejike Innocent Nwankwo, Ebube Victor Emeihe, Mojeed Dayo Ajegbile, Janet Aderonke Olaboye, and Chukwudi Cosmos Maha. "Innovative drug delivery methods for combating antimicrobial resistance." International Medical Science Research Journal 4, no. 8 (2024): 834–58. http://dx.doi.org/10.51594/imsrj.v4i8.1454.

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Antimicrobial resistance (AMR) poses a significant threat to global health, complicating the treatment of infectious diseases and leading to increased morbidity and mortality. Innovative drug delivery methods are emerging as critical strategies to combat AMR by enhancing the efficacy of existing antibiotics and facilitating the development of new therapeutic approaches. This paper explores the role of novel drug delivery systems in addressing AMR challenges. One of the primary approaches is the development of targeted drug delivery systems that improve the precision of antibiotic therapy. Nano

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Abhay, Dhakare* Dr. A. V. Chandewar Dr. Shilpa Gawande Anisha Kohale. "Development And Evaluation of Sustained Release Formulation by Spray Drying Technique." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1506–21. https://doi.org/10.5281/zenodo.15380205.

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The present study focuses on the development and evaluation of sustained release microspheres of Vinpocetine, a poorly water-soluble drug with a short biological half-life, using the spray drying technique. The objective was to enhance the drug’s bioavailability and prolong its therapeutic effect through controlled release delivery. Ethyl cellulose and hydroxypropyl methylcellulose (HPMC) were employed as polymeric carriers to encapsulate Vinpocetine, with varying polymer-to-drug ratios. The prepared microspheres were characterized for particle size, morphology, drug entrapment efficienc

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Kruthi, Gurudev, B. V. Basavaraj, S. Bharath, R. Deveswaran, and V. Madhavan. "SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DELIVERY SYSTEM OF CINNARIZINE." INDIAN DRUGS 51, no. 07 (2014): 31–38. http://dx.doi.org/10.53879/id.51.07.10109.

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The main aim of the present work was to formulate and evaluate sustained release multiparticulate gastroretentive delivery system of cinnarizine. The microspheres were prepared by solvent evaporation method by using Eudragit RS 100 as a polymer in varying ratios. The prepared microspheres were evaluated for drug – polymer compatibility studies, micromeritic properties, drug entrapment efficiency, in vitro buoyancy and drug release studies. The mean particle size increased with increase in polymer concentration, ranging between 60.33 μm to 144.88 μm. FT IR studies showed that the drug and polym

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Kruthi, Gurudev, B. V. Basavaraj, S. Bharath, R. Deveswaran, and V. Madhavan. "SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DELIVERY SYSTEM OF CINNARIZINE." INDIAN DRUGS 51, no. 07 (2014): 31–38. http://dx.doi.org/10.53879/id.51.07.10109.

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The main aim of the present work was to formulate and evaluate sustained release multiparticulate gastroretentive delivery system of cinnarizine. The microspheres were prepared by solvent evaporation method by using Eudragit RS 100 as a polymer in varying ratios. The prepared microspheres were evaluated for drug – polymer compatibility studies, micromeritic properties, drug entrapment efficiency, in vitro buoyancy and drug release studies. The mean particle size increased with increase in polymer concentration, ranging between 60.33 μm to 144.88 μm. FT IR studies showed that the drug and polym

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Sharma, Diksha, Dhruv Dev, D. N. Prasad, and Mansi Hans. "Sustained Release Drug Delivery System with the Role of Natural Polymers: A review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 913–23. http://dx.doi.org/10.22270/jddt.v9i3-s.2859.

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An appropriately designed sustained release dosage form is opted to be a major goal in solving the problems which arises regarding the targeting of a drug to a specific organ or tissue and for controlling its rate of delivery to the target site. The development of oral sustained release system has proven to be a major challenge to formulation scientist due to their inability to restrain as well as localize the system at targeted areas of the gastrointestinal tract. Therefore the development of matrix type drug delivery system is promising option regarding the development of an oral sustained r

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Mamidala, Ranjith Kumar, Vamshi Ramana, Sandeep G, Meka Lingam, Ramesh Gannu, and Madhusudan Rao Yamsani. "Factors Influencing the Design and Performance of Oral Sustained/Controlled Release Dosage Forms." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 583–94. http://dx.doi.org/10.37285/ijpsn.2009.2.3.1.

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Of all drug delivery systems, oral drug delivery remains the most preferred option for administration for various drugs. Availability of wide variety of polymers and frequent dosing intervals helps the formulation scientist to develop sustained/controlled release products. Oral Sustained release (S.R) / Controlled release (C.R) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutic, pharmacokinetic and pharmacodynamic properties of drugs in such a way that it reduces dosing frequency to an extent that once daily dose is sufficient for therapeutic management

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Fateh, Mohd Vaseem, Vikas Kumar, Renu Chaudhary, and Vivak Ujjwal. "Gastro-retentive drug delivery system for treatment of Ulcer." International Journal of Agricultural Invention 3, no. 02 (2019): 203–10. http://dx.doi.org/10.46492/ijai/2018.3.2.18.

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Due to the comfort of administration, economical and extensibility in formulation, the most adopted route to the systemic circulation is the oral route regardless of the astounding elevation in the drug delivery. Oral drug delivery is the most comforting method of delivery due to its comforting method of delivery, due to its better solubility, accurate dosage and simpler production. Approximately 90% of the drugs are administered orally of which solid oral dosage form is the most chosen class of medicaments. Conventional dosage forms usually exhibit the serum drug concentration fluctuations an

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Venkateswarlu, Kambham. "Evaluation of glibenclamide microspheres for sustained release." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 78–87. http://dx.doi.org/10.56499/jppres16.156_5.2.78.

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Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM) were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit RS 100 and xanthan gum. Polymers can sustain the drug release from microspheres. The prepared microsp

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Shounak, Mande*. "A Research Article on Sustained Release Tablet of Salbutamol Sulphate." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1429–41. https://doi.org/10.5281/zenodo.14684858.

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The terms Sustained release used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. There are several reasons for attractiveness of these dosage forms: provides increased bioavailability of drug product, reduction in the frequency of administration to prolong duration of effective blood levels, reduces the fluctuation of peak trough concentration and side effects and possibly improves the specific distribution of the drug. (1).

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Katoriya, V. S., G. S. Deokar, and S. J. Kshirsagar. "IONOTROPIC TRAPPING LECITHIN BASED CILOSTAZOL NANOCOCHLEATES FOR DRUG DELIVERY APPLICATIONS." INDIAN DRUGS 54, no. 09 (2017): 24–32. http://dx.doi.org/10.53879/id.54.09.10682.

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The nanocochleate drug delivery is based on encapsulating drugs in multilayered lipid crystal matrix (a cochleate) to potentially deliver the drug safely and effectively through the lipoidal membrane. Cilostazol is approved for the treatment of intermittent claudication and used as fibrinolytic agent, platelet aggregation inhibitor, bronchodilator agent, phosphodiesterase III Inhibitor and vasodilator agent. therefore, this drug delivery is suitable to deliver drug molecules into blood vessels. Formulations with lecithin showed good in vitro drug release, drug entrapment study results and the

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Mohaniya, Payal, Dipti Modi, and Rajat Pawar. "A REVIEW ON SUSTAINED RELEASE MATRIX TABLET." International Journal of Pharmaceutical Sciences and Medicine 9, no. 2 (2024): 52–58. http://dx.doi.org/10.47760/ijpsm.2024.v09i02.007.

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In the present study Sustained release matrix tablet is formulated mainly by wet granulation or direct compression method .Sustained release drug delivery maintains the therapeutic concentration of drug in the bloodstream over a long period of time and thus improves patient compliance by reducing frequency of dosing, minimized fluctuations in drug levels, lowering the therapeutic index and improving treatment efficacy. Nowadays Matrix tablets as oral solid dosage form are most suitable for the sustained release drug delivery. In a matrix system a drug is homogeneously dispersed or dissolved wi

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Brewer, Erik, Jason Coleman, and Anthony Lowman. "Emerging Technologies of Polymeric Nanoparticles in Cancer Drug Delivery." Journal of Nanomaterials 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/408675.

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Polymeric nanomaterials have the potential to improve upon present chemotherapy delivery methods. They successfully reduce side effects while increasing dosage, increase residence time in the body, offer a sustained and tunable release, and have the ability to deliver multiple drugs in one carrier. However, traditional nanomaterial formulations have not produced highly therapeutic formulations to date due to their passive delivery methods and lack of rapid drug release at their intended site. In this paper, we have focused on a few “smart” technologies that further enhance the benefits of typi

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Lai, Joanne, Abul Kalam Azad, Wan Mohd Azizi Wan Sulaiman, Vinoth Kumarasamy, Vetriselvan Subramaniyan, and Salah Abdalrazak Alshehade. "Alginate-Based Encapsulation Fabrication Technique for Drug Delivery: An Updated Review of Particle Type, Formulation Technique, Pharmaceutical Ingredient, and Targeted Delivery System." Pharmaceutics 16, no. 3 (2024): 370. http://dx.doi.org/10.3390/pharmaceutics16030370.

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Alginate is a natural biopolymer widely studied for pharmaceutical applications due to its biocompatibility, low toxicity, and mild gelation abilities. This review summarizes recent advances in alginate-based encapsulation systems for targeted drug delivery. Alginate formulations like microparticles, nanoparticles, microgels, and composites fabricated by methods including ionic gelation, emulsification, spray drying, and freeze drying enable tailored drug loading, enhanced stability, and sustained release kinetics. Alginate microspheres prepared by spray drying or ionic gelation provide gastri

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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Jeon, Hyunsu, Hyangsu Nam, and Jong Bum Lee. "Sustained Release of Minor-Groove-Binding Antibiotic Netropsin from Calcium-Coated Groove-Rich DNA Particles." Pharmaceutics 11, no. 8 (2019): 387. http://dx.doi.org/10.3390/pharmaceutics11080387.

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Control of the release properties of drugs has been considered a key factor in the development of drug delivery systems (DDSs). However, drug delivery has limitations including cytotoxicity, low loading efficiency, and burst release. To overcome these challenges, nano or micro-particles have been suggested as carrier systems to deliver chemical drugs. Herein, nano-sized DNA particles (DNAp) were manufactured to deliver netropsin, which is known to bind to DNA minor grooves. The rationally designed particles with exposed rich minor grooves were prepared by DNAp synthesis via rolling circle ampl

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Cook, Robert O., Rupi K. Pannu, and Ian W. Kellaway. "Novel sustained release microspheres for pulmonary drug delivery." Journal of Controlled Release 104, no. 1 (2005): 79–90. http://dx.doi.org/10.1016/j.jconrel.2005.01.003.

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Simmons, K. "Localized, sustained-release drug delivery uses membrane "envelope"." JAMA: The Journal of the American Medical Association 254, no. 8 (1985): 1005–7. http://dx.doi.org/10.1001/jama.254.8.1005.

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Harshada, Chavan* Akanksha Patil Dr. Bharat Tekade. "Formulation And Evaluation of Sustained-Released Ivabradine Hydrochloride Tablets Using Natural Gums." International Journal of Scientific Research and Technology 1, no. 12 (2024): 95–106. https://doi.org/10.5281/zenodo.14361372.

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This study investigates the application of natural gums as release-modifying agents in the formulation of sustained-release matrix tablets using Ivabradine Hydrochloride as a model drug. Tablets were prepared via direct compression, using gums such as xanthan, guar, and karaya in varying ratios. Evaluations included pre-compression and post-compression parameters, in-vitro drug release, swelling index, and stability studies. The formulation with xanthan gum at a 1:2 drug-to-polymer ratio exhibited optimal drug release of 98% over 24 hours, following zero-order kinetics. Swelling studies reveal

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Narinder, Singh* Pooja Devi Muskan Sharma Naval Singh. "Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 434–46. https://doi.org/10.5281/zenodo.15334655.

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The advancement of pharmaceutical sciences has led to the development of various novel drug delivery systems (NDDS) that improve the efficacy, safety, and patient compliance of therapeutic agents. Traditional drug administration methods often encounter challenges such as poor bioavailability, non-specific distribution, and the need for frequent dosing. To overcome these limitations, several innovative approaches have been explored. Transdermal drug delivery systems (TDDS) allow for sustained drug release through the skin, bypassing first-pass metabolism. Vesicular drug delivery systems (VDDS),

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