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Dissertations / Theses on the topic 'Sustained Release Matrix Tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Hodsdon, Alison Claire. "Xanthan gum and sodium alginate as sustained-release carriers in hydrophilic matrix tablets." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259859.

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2

Gallardo, Alvarez Diego. "Manufacturing of matrix tablets by combining countercharged poly(meth)acrylate polymers to provide sustained release of highly soluble drugs." Göttingen Cuvillier, 2009. http://d-nb.info/993590594/04.

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3

Lee, Jobina J. N. "Investigations into sustained-release hydrophobic matrix pellet formulations." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275167.

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4

Kanematsu, Akihiro. "Bladder regeneration by bladder acellular matrix combined with sustained release of exogenous growth factor." Kyoto University, 2004. http://hdl.handle.net/2433/147452.

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5

Draganoiu, Elena Simona. "Evaluation Of Kollidon® SR for Ph-Independent Extended Release Matrix Systems." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054756192.

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6

RAJBHANDARI, SANGITA. "THE EFFECTS OF POLYMER BLENDS ON THE RELEASE OF PROPRANOLOL HYDROCHLORIDE." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1005161908.

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7

TILLOTSON, JOHN KING. "DEVELOPMENT AND EVALUATION OF EXTENDED-RELEASE BUMETANIDE TABLETS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085067185.

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8

Pather, Sathasivan Indiran. "An investigation of the production of non-coated sustained release beads by extrusion and Spheronization." University of the Western Cape, 1995. http://hdl.handle.net/11394/8457.

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Doctor Pharmaceuticae - DPharm<br>The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the simplification of production processes. Matrix tablets have been used to sustain the release of numerous drugs and are cheap to prepare. Since they are single-unit dosage forms, however, they display less predictable transit through the gastrointestinal tract. Hence, they provide less reliable blood levels of the drug in comparison with multi partic

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9

Elgaied-Lamouchi, Dhouha. "Découverte de nouveaux excipients pharmaceutiques à base d'amidons modifiés pour une libération prolongée d'une substance active." Thesis, Lille, 2020. https://pepite-depot.univ-lille.fr/.

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Les comprimés matriciels hydrophiles sont fréquemment utilisés pour contrôler la libération d’actif dans les formes galéniques à usage oral. Les amidons représentent un choix intéressant pour cette application. En effet, ce sont des matériaux biocompatibles, biodégradables et disponibles à partir de différentes sources végétales. En plus des amidons natifs, les amidons modifiés (AM) ont été beaucoup étudiés pour la formulation des comprimés matriciels à libération prolongée. Les modifications physico-chimiques peuvent être ajustées de manière à correspondre aux propriétés souhaitées pour une a

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10

Tolia, Gaurav. "Use of Silicone Adhesive for Improving Oral Controlled Delivery." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1521190743860228.

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11

Nieto, Bobadilla Maria Susana. "A new antibacterial agent : in vitro bacteriological characterization and in vitro/in vivo performance of sustained release formulations." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S018/document.

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Introduction : La résistance aux antibiotiques est une menace de santé, il est donc urgent de développer de nouveaux antibactériens. CIN-102, est un nouvel antibactérien développé par une industrie pharmaceutique. Il possède un large-spectre d’action et aucune résistance n’a été développée jusqu’à présent. Parmi les possibles applications thérapeutiques du CIN-102, notre recherche s’est focalisée sur les Maladies Inflammatoires Chroniques de l’Intestin (MICIs). Plusieurs facteurs contribuent à l’étiologie des MICIs. Les bactéries intestinales jouent un rôle important dans ces maladies et une a

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12

Seidenberger, Tanja Verfasser], Karsten [Akademischer Betreuer] [Mäder, Jürgen Akademischer Betreuer] Siepmann, and Reinhard H. H. [Akademischer Betreuer] [Neubert. "Sucrose ester stearates, amphiphilic matrix systems for the formulation of sustained release preparations / Tanja Seidenberger. Betreuer: Karsten Mäder ; Jürgen Siepmann ; Reinhard Neubert." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/1025136012/34.

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13

Santos, Ruberlan de Oliveira. "Desenvolvimento de comprimidos de liberação prolongada de nimesulida contendo ferrita para avaliação do trânsito gastrintestinal por meio de técnica biomagnética." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-14052018-153106/.

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As Formas Farmacêuticas de Liberação Prolongada (FFLP) têm sido uma alternativa eficaz na terapia, pois proporcionam maior adesão do paciente ao tratamento em função da redução da frequência de dosagem ao longo do dia, sendo sua principal característica, a modulação da liberação/dissolução do fármaco. Entretanto, esta etapa pode ser influenciada por diferentes fatores, dentre eles: os físico-químicos relacionados ao fármaco; os farmacêuticos, principalmente relacionados aos excipientes empregados e às técnicas de obtenção da forma farmacêutica (FF) e os fisiológicos do trato gastrintestinal (T

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14

Fichtner, Frauke. "Identification and Variation of some Functionality Related Characteristics of Pharmaceutically Relevant Solid Materials and their Effect on Product Performance." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7462.

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15

Rakkanka, Vipaporn. "A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet." Thesis, 2003. http://hdl.handle.net/1957/30894.

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16

Dhopeshwarkar, Vinayak Ramchandra. "Natural gums as matrix formers in sustained release pharmaceutical tablets /." 1991. http://www.gbv.de/dms/bs/toc/172745314.pdf.

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17

Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.

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Les amidons non modifiées et modifiés représentent un groupe d’excipients biodégradables et abondants particulièrement intéressant. Ils ont été largement utilisés en tant qu’excipients à des fins diverses dans des formulations de comprimés, tels que liants et/ou agents de délitement. Le carboxyméthylamidon sodique à haute teneur en amylose atomisé (SD HASCA) a été récemment proposé comme un excipient hydrophile à libération prolongée innovant dans les formes posologiques orales solides. Le carboxyméthylamidon sodique à haute teneur en amylose amorphe (HASCA) a d'abord été produit par l'éthérif

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18

Sundy, Erica. "A novel tablet design for zero-order sustained-release." Thesis, 2002. https://hdl.handle.net/10539/26107.

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Dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine in the branch of Pharmacy<br>A coated doughnut-shaped tablet is evaluated as its ability to release model drugs at a zero-order rate for 8 to 12 hours. The doughnut-shape tablets were compressed using special designed punches.Automated technology is thus feasible for this system. The coating material , 10% w /w gelatin in HPMC K15M was directly compressed and adhered to the tablet core .<br>IT2018

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19

Feng, Shui-yuan, and 馮水源. "A Preliminary Study of Novel Matrix Type Sustained Release Excipient." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/17455224719337798314.

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碩士<br>嘉南藥理科技大學<br>生物科技系暨研究所<br>94<br>A novel and natural material extracted from plants was investigated as a possible sustained release matrix tablet excipient for gastrointestinal and buccal administration. The material could be prepared by the (1) direct milling of the plant (2) spray drying or freeze-drying of aqueous concentrate after boiling for 3 hours. For the convenience of analysis, the Riboflavin 5''-phosphate sodium was chosen as model compound for gastrointestinal administration. The benzyldamine HCl was chosen as model compound for buccal administration. The matrix ta

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20

Li, Shu-Hui, and 李淑惠. "Preparation and Evaluation of Nicardipine HCl Matrix Tablet for Extended Release." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/53508166659912483998.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>Controlled release may be defined as a technique by which drug are made available to a target at a fixed rate and duration to produce a desirable therapeutic effect. The purpose of the study was to prepare nicardipine matrix for extended release. HPMC was selected as carrier to prepare nicardipine tablets and Sodium alginate and Avicel® were used to confer the release of drug. The response surface methodology (RSM) and multiple responses optimization polynomial equation were used to obtain optimal nicardipine matrix for extended release. First of all the relea

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21

GAO, YU-HONG, and 高聿虹. "The formulation study of controlled release matrix tablet and the development of controlled release Nifedipine pellet." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/34713447090987781967.

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22

Keller, Carol Ann. "Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients." Thesis, 2000. http://hdl.handle.net/1957/33246.

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Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5��g/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses and input rates for sustained release formulations of acetaminophen. Once parameters were selected from the simulations, sample formulations were prepared and tested using standard dissolution techniques. Investigations into dose/size relationships, hydroxyp

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23

Yu, Shu-Hua, and 游淑華. "Development of Sodium Alginate, Carrageenan, Chitosan and Calcium Chloride in the Matrix Control Release Tablet." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/96576812870701236585.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>100<br>This study is to use hydrophilic polymers (sodium alginate and carrageenan) and crosslink agents (calcium chloride and chitosan) to crosslinking reaction. When the tablets were dissolved with water, surface gel was performed and showed drug sustained release. The differential scanning calorimetry analyzer proved no mutual effect between excipients and acetaminophen. To prepare hydrogel matrix sustained release, tablets containing acetaminophen with alginate, carrageenan and chitosan were as the matrix material. The optimal formulation was examined by using in

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24

孟仲麟. "The Study of Oral Sustained Release Dosage Forms of Nifedipine by Matrix Concentration Gradient Method." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/83745342388710674541.

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碩士<br>國防醫學院<br>藥學研究所<br>86<br>Nifedipine, a calcium channel-blocking agent, has widely been used for the treatment of hypertention and coronary heart disease. Because it's half-life is 2-3 hours, we can take the long-term sustained release dosage form to increase the duration and avoid the suddenly change of plasma drug concentration. 　　The objective of this study was to use the non-uniform drug concentration method for preparing oral dosage form of nifedipine with zero-order release. We use two peristaltic pumps, one pumps the matrix solution of vessel A to vessel B, which contains the nifedi

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25

Chaibva, F. A., M. Burton, and Roderick Walker. "Optimization of salbutamol sulfate dissolution from sustained release matrix formulations using an artificial neural network." 2010. http://hdl.handle.net/10962/d1006034.

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An artificial neural network was used to optimize the release of salbutamol sulfate from hydrophilic matrix formulations. Model formulations to be used for training, testing and validating the neural network were manufactured with the aid of a central composite design with varying the levels of Methocel® K100M, xanthan gum, Carbopol® 974P and Surelease® as the input factors. In vitro dissolution time profiles at six different sampling times were used as target data in training the neural network for formulation optimization. A multi layer perceptron with one hidden layer was constructed using

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26

Ahmed, Salah Uddin. "Development of oral sustained release tablet dosage forms for sparingly water soluble and highly water soluble drugs : physicochemical, biopharmaceutical and technological considerations /." 1989. http://www.gbv.de/dms/bs/toc/128347236.pdf.

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