Relevant bibliographies by topics / Sustained Release Pellets

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  2. Dissertations / Theses
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Academic literature on the topic 'Sustained Release Pellets'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Sustained Release Pellets"

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Zhang, Ningning, Zifan Song, Weiguo Qi, Ying Gao, Yang Yang, and Yimin Song. "Optimization of Preparation Process and Pharmacokinetics of APAP Double-Release Pellet Capsules." BIO Web of Conferences 59 (2023): 02016. http://dx.doi.org/10.1051/bioconf/20235902016.

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In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, the immediate and sustained release pellets of a certain proportion were prepared by the fluidized bed coating and the extrusion spheroidization process, respectively. It was founded that both the prepared immediate-release pellets and sustained-release pellets had smooth and round surfaces. The particle size distribution ranged evenly from 16 to 35 mesh. Response surface plots showed that the optimal preparation prescription for immediate-release pellets were that ethanol conc
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Thio, Daniel Robin, Paul Wan Sia Heng, and Lai Wah Chan. "MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets." Pharmaceutics 14, no. 12 (2022): 2812. http://dx.doi.org/10.3390/pharmaceutics14122812.

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Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to the MUPS tableting process could undermine the sustained release function of the EC-coated pellets. Deformability of the pellet core is a factor that can impact the extent of pellet coat damage. Thus, this study was designed to evaluate the relative performance of drug-loaded pellets prepared with ei
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Ibrahim, Mohamed Abbas. "Formulation and evaluation of mefenamic acid sustained release matrix pellets." Acta Pharmaceutica 63, no. 1 (2013): 85–98. http://dx.doi.org/10.2478/acph-2013-0009.

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The objective of the study was to prepare mefenamic acid (MA) sustained release matrix pellets and investigate the formulation parameters affecting pellet attributes and drug release in vitro. Amixer torque rheometer (MTR) was used to characterize the rheological properties of wet mass used in pellet formulation. Mefenamic acid pellets were prepared by extrusion/spheronization techniques using microcrystalline cellulose (MCC) in combination with lactose as pellet forming agents and water as the binding liquid. Also, the prepared pellets were characterized for their particle size and in vitro d
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Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin
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Hong, Bihong, Jianlin He, Jipeng Sun, et al. "Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat." Pharmaceutics 12, no. 1 (2020): 32. http://dx.doi.org/10.3390/pharmaceutics12010032.

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Tetrodotoxin (TTX) was identified as a latent neurotoxin that has a significant analgesia effect. It was rapidly absorbed and excreted in rat after intramuscular (i.m.) injection. To maintain the effect, frequent injections were required. The enteric sustained-release TTX pellets with sucrose pellets as a drug carrier was prepared by fluidized bed spray irrigation, coated in sequence with Eudragit NE30D as a sustained-release layer, hydroxypropyl methylcellulose (HPMC) as a barrier layer and Eudragit L30D-55 as an enteric coating. TTX in the pellets could be sustained released for 12 h in diss
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Wan, Dongwei, Min Zhao, Jingjing Zhang, and Libiao Luan. "Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer." Pharmaceutics 11, no. 6 (2019): 260. http://dx.doi.org/10.3390/pharmaceutics11060260.

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This study aimed to develop a novel sustained release pellet of loxoprofen sodium (LXP) by coating a dissolution-rate controlling sub-layer containing hydroxypropyl methyl cellulose (HPMC) and citric acid, and a second diffusion-rate controlling layer containing aqueous dispersion of ethyl cellulose (ADEC) on the surface of a LXP conventional pellet, and to compare its performance in vivo with an immediate release tablet (Loxinon®). A three-level, three-factor Box-Behnken design and the response surface model (RSM) were used to investigate and optimize the effects of the citric acid content in
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Gupta, Vishal, and Jitendra Gupta. "Formulation and in-vitro anticancer activity of nilotinib immediate release and ibrutinib sustained release pellets." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 31–43. http://dx.doi.org/10.69857/joapr.v12i4.571.

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Background: Blood cancer is a significant contributor to mortality rates worldwide, and its prevalence is projected to rise on a global scale. This trend places considerable strain on healthcare systems and necessitates the expedited development of innovative treatments by pharmaceutical firms to remain competitive. Conventional pellets produce rapid plasma drug levels, but they might cause side effects, decrease effectiveness, and lead to poor therapeutic management. Ibrutinib and Nilotinib are employed to treat leukemia patients. Methodology: The current research aims to formulate, character
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Shweta, Saini* Amit Kumar. "Sustained Release Pellets for Antidiuretic Drugs Formulation & Clinical Evaluation." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3131–38. https://doi.org/10.5281/zenodo.15295146.

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Desmopressin acetate (DDAVP) is an oligopeptide used to treat primary nocturnal enuresis, for example. The low oral bioavailability of DDAVP has expedited the move to other modes of administration such as nasal and oromucosal, with nasal administration resulting in large variations, raising the likelihood of unpleasant side effects. Hyponatremia is common in clinical practice and is mainly caused by renal water retention. Many drugs are thought to be among the different causes of hyponatremia because they either promote the production of arginine vasopressin (AVP) or increase its effect in the
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Bodhankar, Shishupal S., and Mohini Sihare. "Formulation and Evaluation of Multiparticulate Pellet Systems for Antidiabetic and Antihypertensive Drugs: Application of Extrusion– Spheronization and Solution Layering Techniques." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.10.

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The present study focuses on the development and comprehensive evaluation of sustained and controlled release multiparticulate pellet formulations for three therapeutic agents: Tolbutamide, Saxagliptin, and Verapamil. The primary objective was to enhance drug release profiles and patient compliance using extrusion–spheronization and solution layering techniques. Tolbutamide and Verapamil were formulated into matrix-based sustained release pellets using hydrophilic polymers (HPMC) and plasticizers (MCC), while Saxagliptin pellets were prepared via solution layering on nonpareil seeds with optio
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Ibrahim, Mohamed Abbas, and Doaa Hasan Alshora. "Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization." Polymers 13, no. 22 (2021): 4034. http://dx.doi.org/10.3390/polym13224034.

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Aceclofenac (AC) is a nonsteroidal anti-inflammatory drug used in the treatment of chronic pain in conditions such as rheumatoid arthritis, with frequent administration during the day. The formulation of sustained release matrix pellets can provide a promising alternative dosage form that controls the release of the drug, with less blood fluctuation and side effects—especially those related to the gastric system. The extrusion/spheronization technique was used to formulate AC matrix pellets. The response surface methodology (version 17.2.02.; Statgraphics Centurion) was used to study the impac
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Dissertations / Theses on the topic "Sustained Release Pellets"

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Pöllinger-Tieg, Catherine [Verfasser], K. [Akademischer Betreuer] Mäder, J. [Akademischer Betreuer] Siepmann, and J. [Akademischer Betreuer] Kressler. "Development and investigation of Propranolol HCl pellets coated with poly(vinyl acetate) based polymer films for sustained release applications / Catherine Pöllinger-Tieg. Betreuer: K. Mäder ; J. Siepmann ; J. Kressler." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2012. http://d-nb.info/1029083649/34.

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Lee, Jobina J. N. "Investigations into sustained-release hydrophobic matrix pellet formulations." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275167.

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Wilding, Ian Robert. "Some studies of oral sustained release of pellet systems." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319343.

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Andreazza, Itamar Francisco. "Desenvolvimento e avaliação de péletes de ácido ascórbico obtidos pela tecnologia de extrusão-esferonização." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-25032014-095739/.

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O objetivo do presente trabalho foi desenvolver e avaliar péletes para compor sistema multiparticulado contendo ácido ascórbico, bem como validar metodologia analítica por cromatografia líquida de alta eficiência (CLAE) para aplicação em ensaio de dissolução destas formas farmacêuticas. A técnica de extrusão-esferonização foi utilizada por ser de fácil aplicação a nível laboratorial e industrial obtendo-se péletes matriciais, compostos de Methocel® K4M, Methocel® K100M e Eudragit® L 100, e péletes de liberação convencionais, para revestimento em leito fluidizado com Kollicoat® SR 30 D como age
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Liu, Dean-Mo, and 劉典謨. "Preparation and Drug Release Studies of Rhodiola Rosea Sustained Release Pellets." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/73410204243858397631.

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碩士<br>高雄醫學大學<br>藥學研究所碩士在職專班<br>93<br>Rhodiola rosea L. is a kind of multipurpose plant at altitudes in Europe and Asia. It has been a long time since were used in the traditional medical system, as an adaptogen, anti-inflammation, altitude sickness prevention. With the strongly anti-oxidative property, high activity of anti-fatigue and great efficacy for improving physical working capacity, today it has become an important component of dietary supplements. In order to find out the best extract condition we extracted the salidroside ingredients from Rhodiola rosea with CO2 supercritical fluid e
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Chen, Shou-Chiung, and 陳守瓊. "The study of preparation for high dose sustained-release pellets." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/53411143860429599687.

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博士<br>台北醫學院<br>藥學研究所<br>85<br>The object of this study was to develop a high dose pellet dosage form for a drug with poor powder characteristics and low density. The specific aims were to study the effects of the physical modification of powder and manufacturing process on the physical characteristics of the treated powder and so obtained pellets, and their in vitro dissolution. Extrusion- spheronization technology was chosen as a basic method since it has been proved to be effective in the
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Mathir, Zohra Mohamed. "Pharmaceutical availability on newly formulated oral sustained release pellets containing the antihistamine, chlorpheniramine maleate." Thesis, 1991. http://hdl.handle.net/10413/8017.

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The main objective of the present study was to determine the feasibility of obtaining aqueous polymer-coated pellet formulations using EudragitR NE 30 D dispersion and chlorpheniramine maleate as the model drug. Many factors influence the rate of drug release from coated beads including, the substrate, the coating formulation and the coating process. A drug release profile that was comparable to that of the reference standard, DykatussR Capsules was obtained with a formulation employing 8.3% EudragitR NE 30 D, 0.5% talc and 1% polyethylene glycol. In vitro dissolution tests on this formulation
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Yuan, Liu-Chun, and 劉峻源. "Application of agar for enhancing the dissolution of poorly soluble drugs and different release from sustain released pellets." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/25943107997257402393.

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碩士<br>嘉南藥理科技大學<br>藥學系<br>102<br>Dripping pellets can be originated in the chinese traditional herbs. We made the herbs to the powder and be dripped into the cooling liquid and made the immediate-release form pellet. Later, with the advances in medical technology, we wanted pellet not only be used at immediate-release pellet form. For our research, we wanted to make extended-release form pellets enhancing the dissolution of poorly soluble drugs and release but keep preservative still staying in the pellet. At first, we referred to the past research and let our poorly soluble preservative and d
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Books on the topic "Sustained Release Pellets"

1

Kwong, Alan Kwok-Hung. Sustained release of insulin from polylactic acid microbeads and pellets. 1986.

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Conference papers on the topic "Sustained Release Pellets"

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Haaser, Miriam, Youness Karrout, Carine Velghe, et al. "Evaluating critical film coating characteristics of sustained-release coated pellets with different size using terahertz pulsed imaging." In The 2nd Electronic Conference on Pharmaceutical Sciences. MDPI, 2012. http://dx.doi.org/10.3390/ecps2012-00808.

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You might also be interested in the extended bibliographies on the topic 'Sustained Release Pellets' for particular source types:
Journal articles
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