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Journal articles on the topic 'Sustained Release Pellets'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhang, Ningning, Zifan Song, Weiguo Qi, Ying Gao, Yang Yang, and Yimin Song. "Optimization of Preparation Process and Pharmacokinetics of APAP Double-Release Pellet Capsules." BIO Web of Conferences 59 (2023): 02016. http://dx.doi.org/10.1051/bioconf/20235902016.

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In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, the immediate and sustained release pellets of a certain proportion were prepared by the fluidized bed coating and the extrusion spheroidization process, respectively. It was founded that both the prepared immediate-release pellets and sustained-release pellets had smooth and round surfaces. The particle size distribution ranged evenly from 16 to 35 mesh. Response surface plots showed that the optimal preparation prescription for immediate-release pellets were that ethanol conc

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2

Thio, Daniel Robin, Paul Wan Sia Heng, and Lai Wah Chan. "MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets." Pharmaceutics 14, no. 12 (2022): 2812. http://dx.doi.org/10.3390/pharmaceutics14122812.

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Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to the MUPS tableting process could undermine the sustained release function of the EC-coated pellets. Deformability of the pellet core is a factor that can impact the extent of pellet coat damage. Thus, this study was designed to evaluate the relative performance of drug-loaded pellets prepared with ei

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3

Ibrahim, Mohamed Abbas. "Formulation and evaluation of mefenamic acid sustained release matrix pellets." Acta Pharmaceutica 63, no. 1 (2013): 85–98. http://dx.doi.org/10.2478/acph-2013-0009.

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The objective of the study was to prepare mefenamic acid (MA) sustained release matrix pellets and investigate the formulation parameters affecting pellet attributes and drug release in vitro. Amixer torque rheometer (MTR) was used to characterize the rheological properties of wet mass used in pellet formulation. Mefenamic acid pellets were prepared by extrusion/spheronization techniques using microcrystalline cellulose (MCC) in combination with lactose as pellet forming agents and water as the binding liquid. Also, the prepared pellets were characterized for their particle size and in vitro d

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4

Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin

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Hong, Bihong, Jianlin He, Jipeng Sun, et al. "Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat." Pharmaceutics 12, no. 1 (2020): 32. http://dx.doi.org/10.3390/pharmaceutics12010032.

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Tetrodotoxin (TTX) was identified as a latent neurotoxin that has a significant analgesia effect. It was rapidly absorbed and excreted in rat after intramuscular (i.m.) injection. To maintain the effect, frequent injections were required. The enteric sustained-release TTX pellets with sucrose pellets as a drug carrier was prepared by fluidized bed spray irrigation, coated in sequence with Eudragit NE30D as a sustained-release layer, hydroxypropyl methylcellulose (HPMC) as a barrier layer and Eudragit L30D-55 as an enteric coating. TTX in the pellets could be sustained released for 12 h in diss

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Wan, Dongwei, Min Zhao, Jingjing Zhang, and Libiao Luan. "Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer." Pharmaceutics 11, no. 6 (2019): 260. http://dx.doi.org/10.3390/pharmaceutics11060260.

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This study aimed to develop a novel sustained release pellet of loxoprofen sodium (LXP) by coating a dissolution-rate controlling sub-layer containing hydroxypropyl methyl cellulose (HPMC) and citric acid, and a second diffusion-rate controlling layer containing aqueous dispersion of ethyl cellulose (ADEC) on the surface of a LXP conventional pellet, and to compare its performance in vivo with an immediate release tablet (Loxinon®). A three-level, three-factor Box-Behnken design and the response surface model (RSM) were used to investigate and optimize the effects of the citric acid content in

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Gupta, Vishal, and Jitendra Gupta. "Formulation and in-vitro anticancer activity of nilotinib immediate release and ibrutinib sustained release pellets." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 31–43. http://dx.doi.org/10.69857/joapr.v12i4.571.

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Background: Blood cancer is a significant contributor to mortality rates worldwide, and its prevalence is projected to rise on a global scale. This trend places considerable strain on healthcare systems and necessitates the expedited development of innovative treatments by pharmaceutical firms to remain competitive. Conventional pellets produce rapid plasma drug levels, but they might cause side effects, decrease effectiveness, and lead to poor therapeutic management. Ibrutinib and Nilotinib are employed to treat leukemia patients. Methodology: The current research aims to formulate, character

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8

Shweta, Saini* Amit Kumar. "Sustained Release Pellets for Antidiuretic Drugs Formulation & Clinical Evaluation." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3131–38. https://doi.org/10.5281/zenodo.15295146.

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Desmopressin acetate (DDAVP) is an oligopeptide used to treat primary nocturnal enuresis, for example. The low oral bioavailability of DDAVP has expedited the move to other modes of administration such as nasal and oromucosal, with nasal administration resulting in large variations, raising the likelihood of unpleasant side effects. Hyponatremia is common in clinical practice and is mainly caused by renal water retention. Many drugs are thought to be among the different causes of hyponatremia because they either promote the production of arginine vasopressin (AVP) or increase its effect in the

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9

Bodhankar, Shishupal S., and Mohini Sihare. "Formulation and Evaluation of Multiparticulate Pellet Systems for Antidiabetic and Antihypertensive Drugs: Application of Extrusion– Spheronization and Solution Layering Techniques." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.10.

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The present study focuses on the development and comprehensive evaluation of sustained and controlled release multiparticulate pellet formulations for three therapeutic agents: Tolbutamide, Saxagliptin, and Verapamil. The primary objective was to enhance drug release profiles and patient compliance using extrusion–spheronization and solution layering techniques. Tolbutamide and Verapamil were formulated into matrix-based sustained release pellets using hydrophilic polymers (HPMC) and plasticizers (MCC), while Saxagliptin pellets were prepared via solution layering on nonpareil seeds with optio

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10

Ibrahim, Mohamed Abbas, and Doaa Hasan Alshora. "Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization." Polymers 13, no. 22 (2021): 4034. http://dx.doi.org/10.3390/polym13224034.

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Aceclofenac (AC) is a nonsteroidal anti-inflammatory drug used in the treatment of chronic pain in conditions such as rheumatoid arthritis, with frequent administration during the day. The formulation of sustained release matrix pellets can provide a promising alternative dosage form that controls the release of the drug, with less blood fluctuation and side effects—especially those related to the gastric system. The extrusion/spheronization technique was used to formulate AC matrix pellets. The response surface methodology (version 17.2.02.; Statgraphics Centurion) was used to study the impac

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Anisha, Kohale Dr. A. V. Chandewar Dr. S. R. Gawande Abhay Dhakare Anjali Bhansali Ashwini Warankar. "Formulation And Evaluation of Pellets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2582–91. https://doi.org/10.5281/zenodo.15429349.

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The present study focuses on the formulation and evaluation of Esomeprazole-coated sustained release pellets using various polymers in different ratios. Esomeprazole, a proton pump inhibitor, is acid-labile and requires protection from gastric acid for effective intestinal absorption. In this research, non-pareil (NP) seeds were prepared using the extrusion-spheronization process and subsequently coated with Esomeprazole and sustained release polymers through the pan coating method. Various polymer ratios were applied to assess their effect on drug release behavior. The formulated pellets were

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K, Kowshik, Vishal Gupta N, Gowda Dv, and Praveen Sivadasu. "FORMULATION OF IMMEDIATE RELEASE (IR) ATORVASTATIN CALCIUM PELLETS AND SUSTAINED RELEASE (SR) GLIBENCLAMIDE FOR FIXED-DOSE COMBINATION DOSAGE FORM." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (2018): 159. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.26629.

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Objective: The objective of the present research was to develop fixed-dose combinations for the treatment of dyslipidemia, associated with type-II diabetes mellitus for improvement of glucose tolerance.Methods: Multiple unit pellet systems (MUPSs) consisting immediate release atorvastatin calcium pellets and sustained release glibenclamide were formulated by spheronization technique. The characterization of formulated pellets was done by Fourier transform infrared (FT-IR) and differential scanning calorimetry (DSC) studies, and formulated pellets were evaluated for solubility, viscosity, pH, a

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13

Pravina, Gurjar, and Pavani S. "Formulation Development of Sustained Release Matrix Pellets Compressed into Unit Dosage Form." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 13, no. 03 (2022): 108–22. http://dx.doi.org/10.25258/ijpqa.13.3.10.

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>Any drug delivery system’s main objective is to consistently deliver the desired drug concentration in the blood or tissues, which is therapeutically beneficial and non-toxic. The spherical, free-flowing granules known as pellets increase bioavailability, lower the risk of dose dumping and local gastrointestinal discomfort, regulate drug release, and boost absorption of the medicine. A second-generation sulfonylurea called gliclazide is used to treat non-insulin-dependent diabetic mellitus (NIDDM). This study’s objectives were to construct a flexible dosage form with controlled release and

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14

Ramya, Devoju, and Dr M. Sunitha Reddy. "Formulation and Evaluation of Sustained Release Pellets of Verapamil HCL." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 536–41. http://dx.doi.org/10.36348/sjmps.2022.v08i10.007.

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Verapamil Hydrochloride, an antihypertensive agent which is used as a calcium channel blocker. The aim of the present study was to formulate and evaluate Verapamil HCL sustained release pellets. The work is to obtain Verapamil HCL sustained release pellets by using HPMC based polymers i.e., HPMC AN6, HPMC E5, HPMC E15 in the sustained release layer. The verapamil Hydrochloride has pH-dependent solubility. To overcome the pH dependent solubility Fumaric acid was used that which provides micro-acidic environment. Different Ratios of Ethyl-cellulose and HPMC polymers were used to optimise and eva

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15

Handattu, Maithri S., Shailesh Thirumaleshwar, Gowrav M. Prakash, Hemanth K. Somareddy, and Gangadharappa H. Veerabhadrappa. "A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals." Current Drug Targets 22, no. 10 (2021): 1183–95. http://dx.doi.org/10.2174/1389450122999210120204248.

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Oral route of administration is widely accepted and desired because of its versatility, convenience, and, most importantly, patient compliance. Multiparticulate systems like granules and pellets are more advantageous when compared to single-unit dosage forms, as they are capable of distributing the drug more evenly in the gastrointestinal tract. The current paper focuses on pellets, the merits and demerits associated, various pelletization techniques, and their characterization. It also focuses on how pellets can be employed for drug delivery is controlled and sustained release formulations. I

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Khatri, Raj, Munira Momin, Sankalp Gharat, and Mansi Damani. "FORMULATION AND DEVELOPMENT OF BIOADHESIVE PELLETS FOR MANAGEMENT OF HELICOBACTER PYLORI INFECTION." INDIAN DRUGS 61, no. 01 (2024): 53–60. http://dx.doi.org/10.53879/id.61.01.13983.

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Helicobacter pylori, a gram-negative bacterium, is a group I carcinogen which is responsible for duodenal ulcer, gastric ulcer, and gastric cancer. The existing treatment is based on the use of proton pump inhibitors, but is inadequate owing to factors such as low concentration of drug reaching the target site, short residence time, and resistance to activity. Intending to mitigate these limitations, bioadhesive pellets of tinidazole and pantoprazole sodium sesquihydrate for the management of H. pylori infection were developed. Tinidazole-loaded pellets will act on gastric mucosa and pantopraz

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17

Yu, Zhou, Jie Zhao, Yinfeng Hua, Xiaoying Li, Qincheng Chen, and Guoqing Shen. "Optimization of Granulation Process for Binder-Free Biochar-Based Fertilizer from Digestate and Its Slow-Release Performance." Sustainability 13, no. 15 (2021): 8573. http://dx.doi.org/10.3390/su13158573.

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Granulation of biochar-based fertilizer is one potential method to reduce transportation costs, provide for enhanced handling, and decrease the loss of fertilizer during soil application. This study aimed to synthesize binder-free biogas residue biochar-based fertilizer (RBF) pellets and investigate their physical properties and slow-release potential. Results showed that the physical properties and forming quality of the pellets reached the best when the moisture content was 7.84%, the diameter was 7 mm, the compression speed was 49.54 mm/min, and the molding pressure was 7.5 MPa. Sustained-r

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18

Mahrous, G. M., M. A. Ibarhim, M. El-Badry, and F. K. Al-Anazi. "Indomethacin sustained release pellets prepared by extrusion-spheronization." Journal of Drug Delivery Science and Technology 20, no. 2 (2010): 119–25. http://dx.doi.org/10.1016/s1773-2247(10)50016-9.

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19

Umprayn, Kaisri, Padungkwan Chitropas, and Sukavat Amarekajorn. "Development of Terbutaline Sulfate Sustained-Release Coated Pellets." Drug Development and Industrial Pharmacy 25, no. 4 (1999): 477–91. http://dx.doi.org/10.1081/ddc-100102198.

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20

Lam, Matthew, Nour Nashed, and Ali Nokhodchi. "Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from Liqui-Pellets." Pharmaceutics 13, no. 7 (2021): 1049. http://dx.doi.org/10.3390/pharmaceutics13071049.

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The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on sustained-release formulation using the Liqui-Mass technology. In this study, an attempt was made to produce a sustained-release Liqui-Tablet for the first time using a matrix-based approach. The non-volatile co-solvent used in the investigation included Tween 80, Tween 20 and Kolliphor EL. The production of sustained-release propranolol hydrochloride Liqui-Tablet was su

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21

Formulation, and Evaluation of Sustained Release Pellets of Oral Antidiabetic Agent by Using Natural Polymer, and Giram* Diptee Bhagwat Dr. K. R. Biyani Rutuja. "Formulation and Evaluation of Sustained Release Pellets of Oral Antidiabetic Agent by Using Natural Polymer." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3060–65. https://doi.org/10.5281/zenodo.15458667.

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In the present study we concluded that, the formulation and assessment of sustained release tablets utilizing natural polymers are the main topics of the review.  Long-term medication release is the goal of sustained release (SR) dose forms, which increase patient compliance and therapeutic efficacy.  The benefits and drawbacks of sustained release tablets are covered in the study along with preparation techniques and the many natural polymers that are utilized in these formulations.  Natural polymers that have been shown to improve drug release characteristics include chitosan,

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22

Barbosa, Eduardo José, and Humberto Gomes Ferraz. "Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations." Acta Pharmaceutica 69, no. 1 (2019): 99–109. http://dx.doi.org/10.2478/acph-2019-0007.

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Abstract The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and diluent factors at three levels each. Pellets were produced by the extrusion/spheronization technique, and dried in a fluid-ized bed. Physical tests and dissolution tests were conducted. The results showed that the binder factor was not significant for pellet size and granulometry distribution. Rather, trends of a different response of gellan gum were identified, in

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Ranjeet, Singh* Dr. Amit Chaudhary. "Coating Techniques for Sustained Release Pellet Dosage Forms: Strategies for Achieving Zero-Order Release Kinetics." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 477–83. https://doi.org/10.5281/zenodo.15334874.

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The pursuit of zero-order drug release has become a key objective in the design of sustained release (SR) oral dosage forms, aiming to maintain constant plasma drug levels and enhance therapeutic efficacy. Pellet-based multiparticulate systems offer significant advantages in controlled drug delivery, including uniform distribution in the gastrointestinal tract, reduced risk of dose dumping, and flexible formulation design. Central to achieving desired release profiles is the application of functional polymer coatings that regulate drug diffusion. This review comprehensively explores coating te

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Ha, Jung-Myung, Ju-Young Kim, Tack-Oon Oh, et al. "Preparation and Evaluation of Sustained-Release Doxazosin Mesylate Pellets." Chemical and Pharmaceutical Bulletin 61, no. 4 (2013): 371–78. http://dx.doi.org/10.1248/cpb.c12-00767.

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Wouessidjewe, D., J. P. Devissaguet, and J. T. Carstensen. "Effect of multiple film coverage in sustained release pellets." Drug Development and Industrial Pharmacy 17, no. 1 (1991): 7–25. http://dx.doi.org/10.3109/03639049109043806.

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Ravella, Venkat N., Rama Rao Nadendla, and Naga Chandrika Kesari. "Design and evaluation of sustained release pellets of aceclofenac." Journal of Pharmacy Research 6, no. 5 (2013): 525–31. http://dx.doi.org/10.1016/j.jopr.2013.04.040.

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27

Han, Xiaopeng, Linan Wang, Yinghua Sun, et al. "Preparation and evaluation of sustained-release diltiazem hydrochloride pellets." Asian Journal of Pharmaceutical Sciences 8, no. 4 (2013): 244–51. http://dx.doi.org/10.1016/j.ajps.2013.09.007.

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Mehmedagić, Aida, Edina Vranić, Sabira Hadžović, et al. "The new trends in theophylline therapy." Bosnian Journal of Basic Medical Sciences 2, no. 1-2 (2002): 62–65. http://dx.doi.org/10.17305/bjbms.2002.3584.

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Sustained-release theophylline pellets formulation for once-daily evening administration significantly improved patients compliance and adjusted serum levels profile of the drug. The patients conversion from i.v. to p.o. therapy is one of the most critical steps in the treatment of asthma according to its chronopathophysiological character. In our study we have examined safety and efficiency of this conversion in twelve hospitalised asthmatic patients who were given the new sustained-release theophylline pellets formulation for once-daily evening administration. The lung function parameters (F

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Cho, Hyuk Jun, Jung Suk Kim, Sung Giu Jin, and Han-Gon Choi. "Development of Novel Tamsulosin Pellet-Loaded Oral Disintegrating Tablet Bioequivalent to Commercial Capsule in Beagle Dogs Using Microcrystalline Cellulose and Mannitol." International Journal of Molecular Sciences 24, no. 20 (2023): 15393. http://dx.doi.org/10.3390/ijms242015393.

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In this study, we developed a tamsulosin pellet-loaded orally disintegrating tablet (ODT) that is bioequivalent to commercially available products and has improved patient compliance using microcrystalline cellulose (MCC) and mannitol. Utilizing the fluid bed technique, the drug, sustained release (SR) layer, and enteric layer were sequentially prepared by coating MCC pellets with the drug, HPMC, Kollicoat, and a mixture of Eudragit L and Eudragit NE, respectively, resulting in the production of tamsulosin pellets. The tamsulosin pellet, composed of the MCC pellet, drug layer, SR layer, and en

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Singh, Inderbir, Gayatri Devi, Bibhuti Ranjan Barik, Anju Sharma, and Loveleen Kaur. "Mucoadhesive Pellets for Drug Delivery Applications: A Critical Review." Reviews of Adhesion and Adhesives 8, no. 2 (2020): 153–67. http://dx.doi.org/10.7569/raa.2020.097305.

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Pellets are spherical shaped multiparticulate drug delivery systems with size ranging between 0.5-2.0 mm. Free flow, good mechanical properties, improved physical and chemical properties of powder, and stability are some advantages of pellets. Mucoadhesive pellets could be developed by using appropriate concentration and type of mucoadhesive polymer. Mucoadhesive pellets can be used for delivery of drugs to gastric, colonic, and vaginal regions. Immediate release, sustained/controlled release and implantable delivery could be incorporated using mucoadhesive pellets. Reproducibility, ease of sc

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Xu, Min, Celine Valeria Liew, and Paul Wan Sia Heng. "Evaluation of the coat quality of sustained release pellets by individual pellet dissolution methodology." International Journal of Pharmaceutics 478, no. 1 (2015): 318–27. http://dx.doi.org/10.1016/j.ijpharm.2014.11.057.

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Ferreira, Guilherme Neves, Marcos Giovani Rodrigues Silva, Aline Guerra Manssour Fraga, et al. "Preparation and scale up of extended-release tablets of bromopride." Brazilian Journal of Pharmaceutical Sciences 50, no. 2 (2014): 291–300. http://dx.doi.org/10.1590/s1984-82502014000200008.

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Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop

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Al-Hashimi, Nihad, Nazish Begg, Raid Alany, Hany Hassanin, and Amr Elshaer. "Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles." Pharmaceutics 10, no. 4 (2018): 176. http://dx.doi.org/10.3390/pharmaceutics10040176.

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Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solution to chronic conditions, patients’ adherence, and swallowing difficulties if incorporated into orodispersible matrices. Nonetheless, the compaction of multiparticulates often damages the functional po

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Wong, Tin Wui, and Harjoh Nurulaini. "Sustained-release alginate-chitosan pellets prepared by melt pelletization technique." Drug Development and Industrial Pharmacy 38, no. 12 (2012): 1417–27. http://dx.doi.org/10.3109/03639045.2011.653364.

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Broomhead, Alan, Raelene West, Gaithry Kadirgamanathan, Kaye Knox, Don Krueger, and Jeffrey Malick. "Comparative Bioavailability of Sustained-Release Morphine Sulfate Capsules versus Pellets." Clinical Drug Investigation 14, no. 2 (1997): 137–45. http://dx.doi.org/10.2165/00044011-199714020-00008.

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Sriamornsak, Pornsak, Sompol Prakongpan, Satit Puttipipatkhachorn, and Ross A. Kennedy. "Development of sustained release theophylline pellets coated with calcium pectinate." Journal of Controlled Release 47, no. 3 (1997): 221–32. http://dx.doi.org/10.1016/s0168-3659(97)01640-4.

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Alshora, Doaa Hasan, Mohamed Abbas Ibrahim, Essam Ezzeldin, and Muzaffar Iqbal. "Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization." Journal of Drug Delivery Science and Technology 59 (October 2020): 101902. http://dx.doi.org/10.1016/j.jddst.2020.101902.

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Narwariya, Shailendra Singh, Insaf Ali, Alok Kumar Soni, and Somesh Godiya. "Formulation optimization and characterization of venlafaxine HCL sustained release pellets." International Journal of Pharmacognosy and Clinical Research 7, no. 2 (2025): 09–24. https://doi.org/10.33545/2664763x.2025.v7.i2a.66.

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Pandit, Ashlesha Pravin, and Rajendra Dattatray Shinde. "Development and in vitro evaluation of sustained release multiparticulate tablet of freely water soluble drug." Brazilian Journal of Pharmaceutical Sciences 46, no. 3 (2010): 463–71. http://dx.doi.org/10.1590/s1984-82502010000300009.

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Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxypropyl methylcellulose (Surelease®: HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease®/ hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The releas

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Hiew, Tze Ning, Desiree Li Hui Tan, Yi Long Tiang, and Paul Wan Sia Heng. "Understanding the release performance of pellets with hydrophobic inclusions in sustained-release coating." International Journal of Pharmaceutics 557 (February 2019): 229–37. http://dx.doi.org/10.1016/j.ijpharm.2018.12.061.

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Liu, Pan, Jin Li, Jianping Liu, Jikun Yang, and Yongqing Fan. "Release Behavior of Tanshinone IIA Sustained-Release Pellets Based on Crack Formation Theory." Journal of Pharmaceutical Sciences 101, no. 8 (2012): 2811–20. http://dx.doi.org/10.1002/jps.23199.

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Xu, Lei, Qingliang Yang, Wei Qiang, et al. "Hydrophilic Excipient-Independent Drug Release from SLA-Printed Pellets." Pharmaceutics 13, no. 10 (2021): 1717. http://dx.doi.org/10.3390/pharmaceutics13101717.

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Three-dimensional (3D) printing technology, specifically stereolithography (SLA) technology, has recently created exciting possibilities for the design and fabrication of sophisticated dosages for oral administration, paving a practical way to precisely manufacture customized pharmaceutical dosages with both personalized properties and sustained drug release behavior. However, the sustained drug release achieved in prior studies largely relies on the presence of hydrophilic excipients in the printing formulation, which unfortunately impedes the printability and formability of the corresponding

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Patil, Arun Trambak, Deepak Shamrao Khobragade, Sandip Annaji Chafle, Amol Prasadrao Ujjainkar, Sudhir Niranjanrao Umathe, and Champalal Laxminarayan Lakhotia. "Development and evaluation of a hot-melt coating technique for enteric coating." Brazilian Journal of Pharmaceutical Sciences 48, no. 1 (2012): 69–77. http://dx.doi.org/10.1590/s1984-82502012000100008.

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Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were

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Pranitha, Parchaki, and Dr M. Sunitha Reddy. "Formulation and Evaluation of Mebeverine Hydrochloride Sustained Release Capsules by Pelletization Technique." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 11 (2022): 644–49. http://dx.doi.org/10.36348/sjmps.2022.v08i11.002.

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The objective of the present study is aimed to formulate and evaluate sustained-release Mebeverine hydrochloride capsules using the Pelletization technique. Mebeverine hydrochloride, an anti-spasmodic drug is highly water soluble with a half-life of 2h and is suitable to develop sustained action for the treatment of irritable bowel syndrome. Mebeverine hydrochloride prolongs medication release in the GIT and, as a result, into the plasma, while reducing the frequency of drug administration, adverse effects, and patient compliance. Mebeverine hydrochloride were prepared by using polymers The dr

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Zhao, Xingna, Guofei Li, Lili Zhang, et al. "Preparation and evaluation of nicotinic acid sustained-release pellets combined with immediate release simvastatin." International Journal of Pharmaceutics 400, no. 1-2 (2010): 42–48. http://dx.doi.org/10.1016/j.ijpharm.2010.08.028.

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Sun, Zhaoying, Shujie Yuan, Huanan Zhao, Zhenyang Wang, and Zhiming Liu. "Preparation and evaluation of 1-deoxynojirimycin sustained-release pellets vs conventional immediate-release tablets." Journal of Microencapsulation 34, no. 3 (2017): 293–98. http://dx.doi.org/10.1080/02652048.2017.1321694.

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Pan, Jin-huo, Jian-chun Wang, Zhi-tao Jiang, et al. "Preparation and pharmacokinetics in beagle dogs of ganershu sustained-release pellets." Pharmacognosy Magazine 10, no. 39 (2014): 217. http://dx.doi.org/10.4103/0973-1296.137360.

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Fetih, Gihan. "FORMULATION AND CHARACTERIZATION OF GELUCIRE PELLETS FOR SUSTAINED RELEASE OF IBUPROFEN." Bulletin of Pharmaceutical Sciences. Assiut 33, no. 2 (2010): 217–24. http://dx.doi.org/10.21608/bfsa.2010.64767.

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Huang, Hui-Feng, Yan Lu, Hai-Bing He, and Xing Tang. "Preparation and Bioavailability of Sustained-Release Doxofylline Pellets in Beagle Dogs." Drug Development and Industrial Pharmacy 34, no. 7 (2008): 676–82. http://dx.doi.org/10.1080/03639040701836552.

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Kramar, A., S. Turk, and F. Vrečer. "Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films." International Journal of Pharmaceutics 256, no. 1-2 (2003): 43–52. http://dx.doi.org/10.1016/s0378-5173(03)00061-9.

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