Relevant bibliographies by topics / Sustained release profile

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Academic literature on the topic 'Sustained release profile'

Author: Grafiati
Published: 9 March 2023

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Journal articles on the topic "Sustained release profile"

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Pradeep Kumar, M., Goparaju Suryanarayana Murthy, Annamdasu Lakshmi Poojitha, P. Sindhuri, A. Sreekanth, and Yerikala Ramesh. "Formulation and Evaluation of Colchicine Sustained release tablet by using factorial designs." Journal of Drug Delivery and Therapeutics 11, no. 5-S (October 26, 2021): 100–107. http://dx.doi.org/10.22270/jddt.v11i5-s.5028.

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The study on the effect of polymer concentration on in vitro drug release profile revealed that there is a change in vitro drug release parameters (t50, t80, and MDT) with a change in polymer concentration. Fraction of HPMC K4M, HPMC K 100 M, and Ethyl Cellulose were required to be 15, 10, and 7 mg respectively for designing optimized batch F7. The release rate of Colchicine decreased proportionally with an increase in the concentration of ethyl Cellulose and HPMC K100 M. Also the high amount of HPMC K4M leads to the less initial release and sustain effect. A theoretical drug release profile was generated using pharmacokinetic parameters of Colchicine. The value of t50 and t80 of theoretical drug release profile was found to be 242 min and 529 min respectively. The similarity factor f2 was applied between the in vitro drug release profile of optimizing batches and theoretical profile, which indicate a decent similarity between all in vitro drug release profiles (f2 = 68.28 for F7). All the batches except F1shows the value of f2 value within a range. Batch F7 showed the highest f2 (f2 = 68.28) among all the batches and this similarity was also reflected in t50 (≈ 256 min) and t80 (≈ 554 min) values. A 23 full factorial design was applied to systemically optimize in vitro drug release profile. The HPMC K4M (X1), Concentration of HPMC K100 M (X2), and concentration of EC (X3) were selected as independent variables. The time required for 50% drug released (t50), the time required for 80% drug release (t80), similarity factor f2, and mean dissolution time (MDT) were selected as dependent variables. The results of full factorial design indicate that the HPMC K4M (X1), Concentration of HPMC K100 M (X2), and concentration of EC (X3) have a significant effect on in vitro drug release profile. To find out the release mechanism the in vitro release data were fitted in the Korsmeyer-Peppas equation. All Batches except F1 and F3 show Anomalous diffusion-controlled release (combined mechanism of diffusion and case II transport).
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Schattenkirchner, M. "The safety profile of sustained-release etodolac." Rheumatology International 13, S2 (June 1993): S31—S35. http://dx.doi.org/10.1007/bf00290282.

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Thanh, Duyen Nguyen Thi, Duc Hoang Van, Minh Vo Xuan, Xuan Dam Thanh Thanh, and Tung Bui Thanh. "Design and Optimization of Hydrophilic Matrix-based Sustained Release Felodipine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (May 31, 2018): 4136–44. http://dx.doi.org/10.37285/ijpsn.2018.11.3.8.

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Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing the bioavailability, decreasing dosing times per day and reducing side effects.The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three dependent variables were percentages of released felodipine at the sampling times 2h, 6h, 10h (Y2, Y6, Y10, respectively). Results: The release profile from the optimized formula almost met the predicted release profile and was similar to reference tablets. The kinetics of drug release the optimized tablets and reference tablets were also followed the Korsmeyer – Peppas model.Conclusion: The optimized formula was obtained, and the in vitro release profile was similar to the predicted profile and reference tablets.
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Jenner, Adrianne L., Federico Frascoli, Chae-Ok Yun, and Peter S. Kim. "Optimising Hydrogel Release Profiles for Viro-Immunotherapy Using Oncolytic Adenovirus Expressing IL-12 and GM-CSF with Immature Dendritic Cells." Applied Sciences 10, no. 8 (April 21, 2020): 2872. http://dx.doi.org/10.3390/app10082872.

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Sustained-release delivery systems, such as hydrogels, significantly improve cancer therapies by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy and immunotherapy (viro-immunotherapy) is naturally improved by these sustained-release systems, as it relies on the continual stimulation of the antitumour immune response. In this article, we consider a previously developed viro-immunotherapy treatment where oncolytic viruses that are genetically engineered to infect and lyse cancer cells are loaded onto hydrogels with immature dendritic cells (DCs). The time-dependent release of virus and immune cells results in a prolonged cancer cell killing from both the virus and activated immune cells. Although effective, a major challenge is optimising the release profile of the virus and immature DCs from the gel so as to obtain a minimum tumour size. Using a system of ordinary differential equations calibrated to experimental results, we undertake a novel numerical investigation of different gel-release profiles to determine the optimal release profile for this viro-immunotherapy. Using a data-calibrated mathematical model, we show that if the virus is released rapidly within the first few days and the DCs are released for two weeks, the tumour burden can be significantly decreased. We then find the true optimal gel-release kinetics using a genetic algorithm and suggest that complex profiles present unnecessary risk and that a simple linear-release model is optimal. In this work, insight is provided into a fundamental problem in the growing field of sustained-delivery systems using mathematical modelling and analysis.
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Khoder, Mouhamad, Henry Gbormoi, Ali Ryan, Ayman Karam, and Raid Alany. "Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads." Pharmaceutics 11, no. 2 (February 15, 2019): 83. http://dx.doi.org/10.3390/pharmaceutics11020083.

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive calcium ALG beads. Unlike traditional ALG beads, BSA-ALG foam beads were able to float and sustain the ciprofloxacin (CIP) release in gastric medium. Interestingly, intestinal beads made of ALG, BSA-ALG physical mixture and BSA-ALG conjugate resulted in different release rates and orders of indomethacin (IND) in simulated intestinal fluids; while beads based on a physical mixture of BSA-ALG resulted in a first order sustained release profile, both systems based on ALG and BSA-ALG conjugate displayed zero order sustained release profiles with IND being released at a slower rate from the conjugate beads.
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Jungnickel, Paul W., and Pierre A. Maloley. "Comment: Adverse-Effect Profile of Sustained-Release Niacin." DICP 25, no. 9 (September 1991): 1014. http://dx.doi.org/10.1177/106002809102500925.

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Rahman, Md Ziaur, Sayed Koushik Ahamed, Sujan Banik, and Mohammad Salim Hossain. "Release Profile of Losartan Potassium from Formulated Sustained Release Matrix Tablet." Bangladesh Pharmaceutical Journal 16, no. 2 (February 20, 2015): 177–83. http://dx.doi.org/10.3329/bpj.v16i2.22301.

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The present study was undertaken to develop sustained release (SR) matrix tablets of Losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by direct compression method along with Kollidon SR and Methyl Cellulose as release retardant polymers. The evaluation involves two stages- the physical properties studies of tablets and in vitro release kinetics assessment. The USP paddle method was selected to perform the dissolution test and 900 ml phosphate buffer of pH 6.8 was used as dissolution medium at 50 rpm at 370C. The release kinetics were analyzed. All the formulations followed Higuchi release kinetics. When the release data was plotted into Korsmeyer-Peppas equation, then it was confirmed that F-1, F-2, F-3, F-4 and F-5 exhibited non-fickian type drug release whereas F-6 exhibited fickian type drug release from the tablet matrix. The in-vitro release studies revealed that the formulation F-2 can be taken as an ideal or optimized formulation of sustained release tablets for 24 hours release as it fulfills all the requirements for sustained release tablet. Furthermore, when the tablets were preheated at different temperature (300C, 450C, 600C) before dissolution they showed decrease in drug release compared with ambient temperature DOI: http://dx.doi.org/10.3329/bpj.v16i2.22301 Bangladesh Pharmaceutical Journal 16(2): 177-183, 2013
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Mishra, DinaNath, Kalpana Nagpal, ShailendraKumar Singh, and Vikas Mathur. "Comparative release profile of sustained release matrix tablets of verapamil HCl." International Journal of Pharmaceutical Investigation 3, no. 1 (2013): 60. http://dx.doi.org/10.4103/2230-973x.108965.

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Dharmayanti, Cintya, Todd A. Gillam, Desmond B. Williams, and Anton Blencowe. "Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates." Polymers 12, no. 12 (December 7, 2020): 2930. http://dx.doi.org/10.3390/polym12122930.

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Despite being one of the first-line treatments for osteoporosis, the bisphosphonate drug class exhibits an extremely low oral bioavailability (<1%) due to poor absorption from the gastrointestinal tract. To overcome this, and to explore the potential for sustained drug release, bioerodible poly(lactic acid) (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) implants loaded with the bisphosphonate alendronate sodium (ALN) were prepared via hot-melt extrusion. The rate of drug release in vitro was modulated by tailoring the ratio of lactide to glycolide in the polymer and by altering the ALN-loading of the implants. All investigated implants exhibited sustained ALN release in vitro between 25 to 130 days, where implants of greater glycolide composition and higher ALN-loadings released ALN more rapidly. All PLGA implants demonstrated a sigmoidal release profile, characterised by an initial surface dissolution phase, followed by a period of zero-order drug diffusion, then relaxation or erosion of the polymer chains that caused accelerated release over the subsequent days. Contrastingly, the PLA implants demonstrated a logarithmic release profile, characterised by a gradual decrease in ALN release over time.
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Li, Xiao Yan, Deng Guang Yu, Fa Ping Jiang, Kong Jing Deng, Zhi Du, and Xia Wang. "Drug Sustained Release Multiple-Component Polymeric Microparticles Fabricated Using an Electrospray Process." Advanced Materials Research 937 (May 2014): 269–75. http://dx.doi.org/10.4028/www.scientific.net/amr.937.269.

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The present study investigates the preparation of ferulic acid (FA) sustained-release cellulose acetate (CA) microparticles, in which a third component, polyvinylpyrrolidone (PVP), was included into the microcomposites for an improved sustained drug release profile. An electrospraying process was exploited for the fabrication of multiple-component microparticles. Under an applied voltage of 18 kV, FA/PVP/CA composite microparticles were successfully generated. Field emission scanning electron microscopic observations demonstrated that these microparticles had an indented surface morphology with an average diameter of 1.71 ± 0.56 μm. The drug presented in the polymeric microparticles in an amorphous state due to the favorable secondary interactions among the components, as verified by the X-ray diffraction (XRD) patterns and attenuated total reflectance Fourier transform spectra. The triple-component microparticles could provide a fine sustained release profiles with full release completeness and small tailing-off release time period. The electrospraying process is a useful tool for developing sustained release microparticles and multiple-component co-existence in the microparticles can be taken to adjust the sustained drug release profiles.
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Dissertations / Theses on the topic "Sustained release profile"

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MODICA, DE MOHAC Laura. "Novel Drug Delivery System for Treatment-Resistant Schizophrenia." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/478483.

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Books on the topic "Sustained release profile"

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Farrar, Keith Thomas. A comparison of the relative bioavailability and release profiles of standard and sustained-release formulationsof indomethacin. Bradford, 1985.

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Book chapters on the topic "Sustained release profile"

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Jee Kanu, Nand, Eva Gupta, Venkateshwara Sutar, Gyanendra Kumar Singh, and Umesh Kumar Vates. "An Insight into Biofunctional Curcumin/Gelatin Nanofibers." In Nanofibers - Synthesis, Properties and Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97113.

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Electrospinning (ESPNG) was used to synthesize ultrathin (UT) and uniform nanofibers (from 5 nm to a few hundred nanometers) of various materials which have biomedical applications (BAs) such as dressing of wounds, drug discharge, and so on and so forth. In the first half of the report, there is an audit on the nanofibers having low diameter so that it could have larger surface area to volume proportion, likewise with that it would have sufficient porosity and improved mechanical properties required for wound healing. Nanofibrous mats (NMs) with high biocompatibility could be utilized during healing of wounds by sustained release of curcumin (Cc) and oxygen. The ESPNG was understood through in-depth numerical investigation in the present report. Furthermore, the process parameters (PMs) were reviewed in depth for their contributions in synthesizing UT - Curcumin/Gelatin (Cc/G) nanofibers (NFs) of optimum diameter. The aim of the discussion was to demonstrate that simply optimizing biofunctional (BF) - Cc/G NFs might not be enough to satisfy experts until they are also given access details about the complete ESPNG method (mathematical mechanism) to improve hold over the synthesis of NMs (suitable for BAs) for the release profile of Cc throughout critical periods of healing process.
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Conference papers on the topic "Sustained release profile"

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Starly, Binil, Shih-Feng Lan, and David Schmidtke. "Customized Release of Metronidazole From Composite Casted Rings of Poly-Caprolactone/Alginate for Periodontal Drug Delivery." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14177.

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Dental implants provide support for dental crowns and bridges by serving as abutments for the replacement of missing teeth. The objective of this study was to demonstrate a novel method of controlled localized delivery of antibacterial agents to an implant site using a custom fabricated ring. The study involved incorporating a model antibacterial agent (metronidazole) into custom designed Poly-ε-Caprolactone/Alginate (PCL/Alginate) composite rings to produce the intended controlled release profile. In vitro release studies indicate that pure (100%) alginate rings exhibited an expected burst release of metronidazole in the first few hours, whereas Alginate/PCL composite rings produced a medium burst release followed by a sustained release for a period greater than 4 weeks. By varying the PCL/Alginate weight ratios, we have shown that we can control the amount of antibacterial agents released to provide the minimal inhibitory concentration needed for adequate protection. The developed system demonstrates a controllable drug release profile and the potential for the ring to inhibit bacterial biofilm growth for the prevention of diseases such as peri-implantitis resulting from bacterial infection at the implant site.
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Hu, Ying, Chun Liu, Yang Liu, Meng-yao Jin, and Xue-nong Zhang. "Notice of Retraction: An Alternative Sustained Release Microsphere of Silk Fibroin-Chitosan: Preparation, Pharmaceutical Characteristics and Pharmacokinetic Profiles." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780318.

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Laera, Davide, Giovanni Campa, Sergio M. Camporeale, Edoardo Bertolotto, Sergio Rizzo, Federico Bonzani, and Antonio Ferrante. "Modelling of Thermoacoustic Combustion Instabilities Phenomena: Application to an Experimental Rig for Testing Full Scale Burners." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-25273.

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This paper concerns the acoustic analysis of self–sustained thermoacoustic pressure oscillations that occur in a test rig equipped with full scale lean premixed burner. The experimental work is conducted by Ansaldo Energia and CCA (Centro Combustione Ambiente) at the Ansaldo Caldaie facility in Gioia del Colle (Italy), in cooperation with Politecnico di Bari. The test rig is characterized by a longitudinal development with two acoustic volumes, plenum and combustion chamber, coupled by the burner. The length of both chambers can be varied with continuity in order to obtain instability at different frequencies. A previously developed three dimensional finite element code has been applied to carry out the linear stability analysis of the system, modelling the thermoacoustic combustion instabilities through the Helmholtz equation under the hypothesis of low Mach approximation. The heat release fluctuations are modelled according to the κ-τ approach. The burner, characterized by two conduits for primary and secondary air, is simulated by means of both a FEM analysis and a Burner Transfer Matrix (BTM) method in order to examine the influence of details of its actual geometry. Different operating conditions, in which self–sustained pressure oscillations have been observed, are examined. Frequencies and growth rates of unstable modes are identified, with good agreement with experimental data in terms of frequencies and acoustics pressure wave profiles.
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Reports on the topic "Sustained release profile"

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Lazonick, William, and Matt Hopkins. Why the CHIPS Are Down: Stock Buybacks and Subsidies in the U.S. Semiconductor Industry. Institute for New Economic Thinking Working Paper Series, September 2021. http://dx.doi.org/10.36687/inetwp165.

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The Semiconductor Industry Association (SIA) is promoting the Creating Helpful Incentives to Produce Semiconductors (CHIPS) for America Act, introduced in Congress in June 2020. An SIA press release describes the bill as “bipartisan legislation that would invest tens of billions of dollars in semiconductor manufacturing incentives and research initiatives over the next 5-10 years to strengthen and sustain American leadership in chip technology, which is essential to our country’s economy and national security.” On June 8, 2021, the Senate approved $52 billion for the CHIPS for America Act, dedicated to supporting the U.S. semiconductor industry over the next decade. As of this writing, the Act awaits approval in the House of Representatives. This paper highlights a curious paradox: Most of the SIA corporate members now lobbying for the CHIPS for America Act have squandered past support that the U.S. semiconductor industry has received from the U.S. government for decades by using their corporate cash to do buybacks to boost their own companies’ stock prices. Among the SIA corporate signatories of the letter to President Biden, the five largest stock repurchasers—Intel, IBM, Qualcomm, Texas Instruments, and Broadcom—did a combined $249 billion in buybacks over the decade 2011-2020, equal to 71 percent of their profits and almost five times the subsidies over the next decade for which the SIA is lobbying. In addition, among the members of the Semiconductors in America Coalition (SIAC), formed specifically in May 2021 to lobby Congress for the passage of the CHIPS for America Act, are Apple, Microsoft, Cisco, and Google. These firms spent a combined $633 billion on buybacks during 2011-2020. That is about 12 times the government subsidies provided under the CHIPS for America Act to support semiconductor fabrication in the United States in the upcoming decade. If the Congress wants to achieve the legislation’s stated purpose of promoting major new investments in semiconductors, it needs to deal with this paradox. It could, for example, require the SIA and SIAC to extract pledges from its member corporations that they will cease doing stock buybacks as open-market repurchases over the next ten years. Such regulation could be a first step in rescinding Securities and Exchange Commission Rule 10b-18, which has since 1982 been a major cause of extreme income inequality and loss of global industrial competitiveness in the United States.
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