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1

Müller, Adrienne C., Srinivas Patnala, Olena Kis, Reina Bendayan, and Isadore Kanfer. "Interactions between Phytochemical Components of Sutherlandia Frutescens and the Antiretroviral, Atazanavir In Vitro: Implications for Absorption and Metabolism." Journal of Pharmacy & Pharmaceutical Sciences 15, no. 2 (2012): 221. http://dx.doi.org/10.18433/j3ns3x.

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Purpose. African traditional medicinal plants, such as Sutherlandia frutescens have the potential to interact pharmacokinetically with the protease inhibitor class of antiretrovirals, thereby impacting on their safety and efficacy. The effects of extracts and phytochemical components of Sutherlandia frutescens, on the in vitro absorption and metabolism of the protease inhibitor, atazanavir were thus investigated. Methods. Aqueous and methanolic extracts of Sutherlandia frutescens were prepared by freeze-drying of hot water and methanol decoctions of Sutherlandia frutescens plant material respe
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2

Fan, Weili, Connor Hines, Shakila Tobwala, William Folk, and Nuran Ercal. "Antioxidant Potency of Sutherlandia frutescens." Free Radical Biology and Medicine 65 (November 2013): S124. http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.702.

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3

Latté, Klaus Peter. "Sutherlandia frutescens (L.) R.Br. - Der Krebsbusch." Zeitschrift für Phytotherapie 26, no. 6 (2005): 300–306. http://dx.doi.org/10.1055/s-2005-925484.

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4

Fernandes, Antonio C., A. Duncan Cromarty, Carl Albrecht, and Constance E. Jansen van Rensburg. "The antioxidant potential of Sutherlandia frutescens." Journal of Ethnopharmacology 95, no. 1 (2004): 1–5. http://dx.doi.org/10.1016/j.jep.2004.05.024.

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5

Olivier, Denise K., Carl F. Albrecht, Ben-Erik van Wyk, and Fanie R. van Heerden. "SU3, an oxocycloartane diglucoside from Sutherlandia humilis." Phytochemistry Letters 2, no. 3 (2009): 123–25. http://dx.doi.org/10.1016/j.phytol.2009.03.005.

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6

Ntuli, S. S. B. N., W. C. A. Gelderblom, D. R. Katerere, and B. I. Ndodo. "Mutagenic and antimutagenic effects of Sutherlandia frutescens." South African Journal of Botany 73, no. 2 (2007): 332–33. http://dx.doi.org/10.1016/j.sajb.2007.02.173.

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7

Zonyane, Samkele, Olaniyi A. Fawole, Chris la Grange, Maria A. Stander, Umezuruike L. Opara, and Nokwanda P. Makunga. "The Implication of Chemotypic Variation on the Anti-Oxidant and Anti-Cancer Activities of Sutherlandia frutescens (L.) R.Br. (Fabaceae) from Different Geographic Locations." Antioxidants 9, no. 2 (2020): 152. http://dx.doi.org/10.3390/antiox9020152.

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Extracts of Sutherlandia frutescens (cancer bush) exhibit considerable qualitative and quantitative chemical variability depending on their natural wild origins. The purpose of this study was thus to determine bioactivity of extracts from different regions using in vitro antioxidant and anti-cancer assays. Extracts of the species are complex and are predominantly composed of a species-specific set of triterpene saponins (cycloartanol glycosides), the sutherlandiosides, and flavonoids (quercetin and kaempferol glycosides), the sutherlandins. For the Folin-Ciocalteu phenolics test values of 93.3
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8

Abdou, P. N., P. Goetz, and K. Ghedira. "Sutherlandia frutescens (L.) R. Br. (Fabaceae) Baguenaudier d’Éthiopie." Phytothérapie 12, no. 3 (2014): 184–88. http://dx.doi.org/10.1007/s10298-014-0866-2.

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9

Grandi, M., L. Roselli, and M. Vernay. "Lessertia (Sutherlandia frutescens) et la fatigue en cancérologie*." Phytotherapie 3, no. 3 (2005): 110–13. http://dx.doi.org/10.1007/s10298-005-0083-0.

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10

Aboyade, Oluwaseyi M., Gustav Styger, Diana Gibson, and Gail Hughes. "Sutherlandia frutescens: The Meeting of Science and Traditional Knowledge." Journal of Alternative and Complementary Medicine 20, no. 2 (2014): 71–76. http://dx.doi.org/10.1089/acm.2012.0343.

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11

Fasinu, Pius S., Heike Gutmann, Hilmar Schiller, Alexander-David James, Patrick J. Bouic, and Bernd Rosenkranz. "The Potential of Sutherlandia frutescens for Herb-Drug Interaction." Drug Metabolism and Disposition 41, no. 2 (2012): 488–97. http://dx.doi.org/10.1124/dmd.112.049593.

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12

Chinkwo, Kenneth Anye. "Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells." Journal of Ethnopharmacology 98, no. 1-2 (2005): 163–70. http://dx.doi.org/10.1016/j.jep.2005.01.016.

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13

Cocke, J. M. "Distribution of the Tabulate Coral Sutherlandia in Oklahoma, Kansas, and Missouri." Transactions of the Kansas Academy of Science (1903-) 89, no. 1/2 (1986): 73. http://dx.doi.org/10.2307/3627737.

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14

Shaik, S., Y. H. Dewir, N. Singh, and A. Nicholas. "Breaking of seed dormancy in the medicinal plant, Sutherlandia frutescens L." South African Journal of Botany 75, no. 2 (2009): 439. http://dx.doi.org/10.1016/j.sajb.2009.02.163.

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15

Mahlaule-Glory, L. M., Z. Mbita, B. Ntsendwana, M. M. Mathipa, N. Mketo, and N. C. Hintsho-Mbita. "ZnO nanoparticles via Sutherlandia frutescens plant extract: physical and biological properties." Materials Research Express 6, no. 8 (2019): 085006. http://dx.doi.org/10.1088/2053-1591/ab1afa.

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16

Lei, Wei, Jimmy D. Browning, Peggy A. Eichen, et al. "Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages." International Immunopharmacology 29, no. 2 (2015): 254–62. http://dx.doi.org/10.1016/j.intimp.2015.11.012.

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17

Acharya, Debabrata, Gill Enslin, Weiyang Chen, Maxleene Sandasi, Thandazile Mavimbela, and Alvaro Viljoen. "A chemometric approach to the quality control of Sutherlandia (cancer bush)." Biochemical Systematics and Ecology 56 (October 2014): 221–30. http://dx.doi.org/10.1016/j.bse.2014.06.009.

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18

Prevoo, Désirée, Pieter Swart, and Amanda C. Swart. "The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes." Journal of Ethnopharmacology 118, no. 1 (2008): 118–26. http://dx.doi.org/10.1016/j.jep.2008.03.019.

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19

Sia, Charles. "Spotlight on Ethnomedicine: Usability of Sutherlandia Frutescens in the Treatment of Diabetes." Review of Diabetic Studies 1, no. 3 (2004): 145. http://dx.doi.org/10.1900/rds.2004.1.145.

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20

Colling, J., J. Kossmann, and N. P. Makunga. "Piecing together Sutherlandia frutescens (L.) R. Br. metabolism using in vitro tools." South African Journal of Botany 75, no. 2 (2009): 396. http://dx.doi.org/10.1016/j.sajb.2009.02.035.

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21

Lei, Wei, Jimmy D. Browning, Peggy A. Eichen, et al. "An Investigation into the Immunomodulatory Activities of Sutherlandia frutescens in Healthy Mice." PLOS ONE 11, no. 8 (2016): e0160994. http://dx.doi.org/10.1371/journal.pone.0160994.

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22

Tai, Joseph, Susan Cheung, Edwin Chan, and David Hasman. "In vitro culture studies of Sutherlandia frutescens on human tumor cell lines." Journal of Ethnopharmacology 93, no. 1 (2004): 9–19. http://dx.doi.org/10.1016/j.jep.2004.02.028.

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23

Muller, Adrienne Carmel, Murray P. Ducharme, and Isadore Kanfer. "Identification of Mechanism and Pathway of the Interaction between the African Traditional Medicine, Sutherlandia Frutescens, and the Antiretroviral Protease Inhibitor, Atazanavir, in Human Subjects Using Population Pharmacokinetic (PK) Analysis." Journal of Pharmacy & Pharmaceutical Sciences 21, no. 1s (2018): 215s—221s. http://dx.doi.org/10.18433/jpps30068.

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Although the use of the indigenous Southern African plant, Sutherlandia frutescens (SF) for the treatment of HIV/AIDS has previously been described, the risk which it may pose to the safety and efficacy of ARVs and the potential mechanisms which underlie such effects may have clinical significance and relevance. The protease inhibitor (PI), atazanavir (ATV) is a substrate of the efflux transporter, P-gp which modulates absorption in the small intestine, as well as CYP3A4 and CYP3A5enzymes which facilitate metabolism in the small intestine and liver. The objective of this study was to investiga
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24

Enogieru, Adaze B., Sylvester I. Omoruyi, and Okobi E. Ekpo. "Aqueous leaf extract of Sutherlandia frutescens attenuates ROS-induced apoptosis and loss of mitochondrial membrane potential in MPP+-treated SH-SY5Y cells." Tropical Journal of Pharmaceutical Research 19, no. 3 (2020): 549–55. http://dx.doi.org/10.4314/tjpr.v19i3.13.

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Purpose: To investigate the neuroprotective activity of the aqueous extract of Sutherlandia frutescens (SF) against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y neuroblastoma cells.
 Methods: SH-SY5Y neuroblastoma cells were divided into different treatment groups: untreated cells, cells treated with MPP+ alone (2 mM), cells pretreated with SF (20 μg) prior to MPP+ (2 mM) treatment and cells treated with SF (20 μg) alone. Twenty-four hours after treatment with MPP+, cell viability was assessed by MTT assay, and changes in cell morphology, intracellular reactive oxygen sp
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25

Chen, Cuiping, William R. Folk, Rodrigo Lazo-Portugal, Thomas M. Finn, and Martha Knight. "Isolation of sutherlandins A, B, C and D from Sutherlandia frutescens (L.) R. Br. by counter-current chromatography using spiral tubing support rotors." Journal of Chromatography A 1508 (July 2017): 7–15. http://dx.doi.org/10.1016/j.chroma.2017.05.027.

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26

Omoruyi, Sylvester, Adaze Enogieru, and Okobi Ekpo. "Preliminary Cytotoxic Activity of Sutherlandia frutescens and Carpobrotus edulis on Malignant glioblastoma Cells." Tropical Journal of Natural Product Research 3, no. 5 (2019): 175–79. http://dx.doi.org/10.26538/tjnpr/v3i5.5.

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27

Kleynhans, R., M. Bulannga, L. Nenungwi, M. T. Lehlaleroa, B. Matsiliza-Mlathi, and M. M. Slabbert. "Preliminary investigations on germination of Sutherlandia frutescens and emergence of Ceratonia siliqua seed." Acta Horticulturae, no. 1204 (June 2018): 153–60. http://dx.doi.org/10.17660/actahortic.2018.1204.20.

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28

Shaik, S., Y. H. Dewir, N. Singh, and A. Nicholas. "Micropropagation and bioreactor studies of the medicinally important plant Lessertia (Sutherlandia) frutescens L." South African Journal of Botany 76, no. 2 (2010): 180–86. http://dx.doi.org/10.1016/j.sajb.2009.10.005.

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29

Faleschini, M. T., M. S. Myer, N. Harding, and G. Fouchè. "Chemical profiling with cytokine stimulating investigations of Sutherlandia frutescens L. R. (Br.) (Fabaceae)." South African Journal of Botany 85 (March 2013): 48–55. http://dx.doi.org/10.1016/j.sajb.2012.11.007.

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30

Mbamalu, Oluchi N., James Syce, and Halima Samsodien. "Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products." Acta Pharmaceutica 67, no. 1 (2017): 137–46. http://dx.doi.org/10.1515/acph-2017-0003.

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Abstract Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated. All three media utilised showed differences in fla
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31

Moshe, Dineo, Herman van der Bank, Michelle van der Bank, and Ben-Erik van Wyk. "Lack of genetic differentiation between 19 populations from seven taxa of Sutherlandia Tribe." Biochemical Systematics and Ecology 26, no. 6 (1998): 595–609. http://dx.doi.org/10.1016/s0305-1978(98)00002-7.

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32

van Wyk, B.-E., and C. Albrecht. "A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae)." Journal of Ethnopharmacology 119, no. 3 (2008): 620–29. http://dx.doi.org/10.1016/j.jep.2008.08.003.

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33

Chadwick, Wayne Anthony, Saartjie Roux, Maryna van de Venter, Johan Louw, and Willem Oelofsen. "Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet." Journal of Ethnopharmacology 109, no. 1 (2007): 121–27. http://dx.doi.org/10.1016/j.jep.2006.07.012.

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34

TOURNEUR, Francis. "Tabulés dinantiens du Sud-Ouest du Portugal [Tabulate corals from the Dinantian of South-Western Portugal]." Geologica Belgica 1, no. 1-4 (1998): 33–40. http://dx.doi.org/10.20341/gb.2014.004.

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A small fauna of Tabulate corals, collected in the Visean of South-Western Portugal (Carrapateira-Bordeira area), is systematically described. The genera Sutherlandia Cocke & Bowsher 1968, Smythina Weyer 1970 and Cladochonus McCoy 1847 are for the first time reported from the Dinantian of Portugal. A similar association is known from the Culm facies of England and Germany. That confirms the close affinities between these regions and Portugal in the early Carboniferous. The growth habits of the corals suggest that the community was living on a soft muddy bottom. A comparison is proposed wit
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35

Moteetee, A., and B.-E. Van Wyk. "The concept of ’Musa-pelo and the medicinal use of shrubby legumes (Fabaceae) in Lesotho." Bothalia 37, no. 1 (2007): 75–77. http://dx.doi.org/10.4102/abc.v37i1.304.

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In the Kingdom of Lesotho, 20 plant species are commonly known as 'Musa-pelo. The term literally means ‘the one who brings back or tums around the heart’. 'Musa-pelo is traditionally used as a sedative and is given as a first aid treatment to bereaved people who are under severe psychological duress or stress. Of the 20 species known as 'Musa-pelo, 17 belong to nine genera of the Fabaceae (Argyrolobium, Crotalaria, Indigofera, Lessertia, Lotononis, Melolobium, Sutherlandia, Tephrosia and Trifolium). The three remaining species namely Cleome monophylla, Heliophila carnosa and Cysticapnos pruino
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36

Skerman, Nicola B., Annie M. Joubert, and Marianne J. Cronjé. "The apoptosis inducing effects of Sutherlandia spp. extracts on an oesophageal cancer cell line." Journal of Ethnopharmacology 137, no. 3 (2011): 1250–60. http://dx.doi.org/10.1016/j.jep.2011.07.054.

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37

Mqoco, T. V., M. H. Visagie, C. Albrecht, and A. M. Joubert. "Differential cellular interaction of Sutherlandia frutescens extracts on tumorigenic and non-tumorigenic breast cells." South African Journal of Botany 90 (January 2014): 59–67. http://dx.doi.org/10.1016/j.sajb.2013.10.008.

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38

Lin, Hui, Glenn A. Jackson, Yuan Lu, et al. "Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush”Sutherlandia frutescensextract." Cell Biology International 40, no. 2 (2015): 131–42. http://dx.doi.org/10.1002/cbin.10544.

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39

Lu, Yuan, Nicholas Starkey, Wei Lei, et al. "Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract." PLOS ONE 10, no. 12 (2015): e0145507. http://dx.doi.org/10.1371/journal.pone.0145507.

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40

Harnett, S. M., V. Oosthuizen, and M. van de Venter. "Anti-HIV activities of organic and aqueous extracts of Sutherlandia frutescens and Lobostemon trigonus." Journal of Ethnopharmacology 96, no. 1-2 (2005): 113–19. http://dx.doi.org/10.1016/j.jep.2004.08.038.

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41

Gouws, Chrisna, Tanya Smit, Clarissa Willers, Hanna Svitina, Carlemi Calitz, and Krzysztof Wrzesinski. "Anticancer Potential of Sutherlandia frutescens and Xysmalobium undulatum in LS180 Colorectal Cancer Mini-Tumors." Molecules 26, no. 3 (2021): 605. http://dx.doi.org/10.3390/molecules26030605.

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Colorectal cancer remains to be one of the leading causes of death worldwide, with millions of patients diagnosed each year. Although chemotherapeutic drugs are routinely used to treat cancer, these treatments have severe side effects. As a result, the use of herbal medicines has gained increasing popularity as a treatment for cancer. In this study, two South African medicinal plants widely used to treat various diseases, Sutherlandia frutescens and Xysmalobium undulatum, were evaluated for potential activity against colorectal cancer. This potential activity for the treatment of colorectal ca
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42

Leisching, G., B. Loos, T. Nell, and A. M. Engelbrecht. "Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cancer cells." South African Journal of Botany 100 (September 2015): 20–26. http://dx.doi.org/10.1016/j.sajb.2015.04.013.

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43

Camille, N., and G. Dealtry. "Regulation of M1/M2 macrophage polarization by Sutherlandia frutescens via NFkB and MAPK signaling pathways." South African Journal of Botany 116 (May 2018): 42–51. http://dx.doi.org/10.1016/j.sajb.2018.02.400.

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44

Zonyane, S., and NP Makunga. "Variations in metabolomic profiles of populations of the medicinal plant Sutherlandia frutescens in South Africa." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596225.

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45

MacKenzie, Janine, Trevor Koekemoer, Maryna van de Venter, Gill Dealtry, and Saartjie Roux. "Sutherlandia frutescens limits the development of insulin resistance by decreasing plasma free fatty acid levels." Phytotherapy Research 23, no. 11 (2009): 1609–14. http://dx.doi.org/10.1002/ptr.2830.

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46

Jiang, Jinghua, Dennis Y. Chuang, Yijia Zong, et al. "Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells." PLoS ONE 9, no. 2 (2014): e89748. http://dx.doi.org/10.1371/journal.pone.0089748.

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47

Ojewole, John A. O. "Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract." Brain Research Bulletin 75, no. 1 (2008): 126–32. http://dx.doi.org/10.1016/j.brainresbull.2007.08.002.

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48

Shaik, S., Y. H. Dewir, N. Singh, and A. Nicholas. "Influences of pre-sowing seed treatments on germination of the cancer bush (Sutherlandia frutescens), a reputed medicinal plant in arid environments." Seed Science and Technology 36, no. 3 (2008): 795–801. http://dx.doi.org/10.15258/sst.2008.36.3.31.

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49

Vorster, Chris, Andre Stander, and Annie Joubert. "Differential signaling involved in Sutherlandia frutescens-induced cell death in MCF-7 and MCF-12A cells." Journal of Ethnopharmacology 140, no. 1 (2012): 123–30. http://dx.doi.org/10.1016/j.jep.2011.12.045.

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50

Mncwangi, N. P., and A. M. Viljoen. "Quantitative variation of amino acids in Sutherlandia frutescens (Cancer bush)—towards setting parameters for quality control." South African Journal of Botany 82 (September 2012): 46–52. http://dx.doi.org/10.1016/j.sajb.2012.06.009.

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