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Dissertations / Theses on the topic 'Suzuki Coupling Reaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Daku, Kokovi Lawson. "Applications of the Suzuki cross coupling reaction." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425882.

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2

Hashimoto, Toru. "Development of Iron-Catalyzed Suzuki-Miyaura Coupling Reaction." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/159407.

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3

Kuvayskaya, Anastasia, and Aleksey Vasiliev. "Use of Suzuki Coupling Reaction for Synthesis of Functionalized Materials." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/162.

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Hybrid materials synthesized by grafting of organic molecules onto silica surface have found numerous applications in chemistry, biochemistry, and chemical engineering. In particular, the functionalization of silica gel can be accomplished by various surface reactions of immobilized boronic acids. Suzuki coupling has been chosen due to several advantages, such as mild reaction conditions, tolerance to the aqueous environment, and high yields of the products. The objective of this work was to determine the most effective reaction conditions for modifying porous hybrid materials with large speci

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4

Geogheghan, Katherine Jayne. "Boronic acid speciation in Suzuki-Miyaura cross-coupling." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33092.

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Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed coupling of an organoboron and organohalide compounds proceeds through a three-stage mechanism of oxidative addition, transmetalation and reductive elimination. The transmetalation of boronic acids to a palladium(II) complex has been widely studied. However, very little is known about the transmetalation of boronic esters, which are commonly used as an alternative to unstable boronic acids. Whether these species undergo direct

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5

Heaner, William. "Indole synthesis: Knoevenagel/Hemetsberger reaction sequence; Suzuki coupling reactions of basic nitrogen containing substrates." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52171.

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A series of substituted indoles have been synthesized by the sequential reaction of aromatic aldehydes with ethyl azidoacetate in the presence of sodium ethoxide to form the corresponding ethyl α-azido-β-arylacrylates (Knoevenagel process) followed by a solvent mediated thermolysis (Hemetsberger process). The isolated yields of the ethyl α-azido-β-arylacrylates were significantly increased when employing the sacrificial electrophile ethyl trifluoroacetate. 1H NMR and coupled 1H-13C NMR analysis of the ethyl α-azido-β-arylacrylates indicate that the condensation is stereospecific—only the Z

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6

Hassanzadeh, Nazanin. "Suzuki reactions in novel liquids." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-106739.

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Non-ionic deep eutectic solvent (ni-DES) possesses various advantages such as good solvation, biodegradability, and non-toxicity which makes it a perfect and environmentally friendly solvent for organic synthesis. A Pd (OAc)2 catalyzed, Suzuki reaction of aryl bromide and N-heteroaryl halide with arylboronic acid in green and novel solvent (ni-DES) is described. In this work, the possibility of using ni-DES and the impact of this solvent on the scope of the reaction is studied. It is illustrated that using the mixture of N-alkyl derivatives of urea and acetamide as a green solvent for Suzuki r

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7

Chang, Weng Kun. "Development of Tandem Reaction for Synthesis of Highly Functionalized Carbocycles." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104067.

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Thesis advisor: James P. Morken<br>The Suzuki-Miyaura cross-coupling reaction is a common strategy for the formation of a new carbon-carbon bond in organic synthesis. However, intramolecular coupling of allylboron ester and aryl electrophiles has never been reported. Herein, Pd-catalyzed intramolecular cross-coupling of allylboronic pinacol ester and vinyl or aryl bromides is presented. Pt-catalyzed 1,2-diboration of 1,3-dienes give α-chiral bis-allylboronic esters, which can undergo diastereoselective additions to carbonyl electrophiles tethered to vinyl or aryl halides to generate a new ally

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8

Watts, Nicola Louisa. "Improving the scope and understanding of the Symmetric and Asymmetric Suzuki coupling reaction." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/48116/.

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Investigations into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and stoichiometrically efficient process. This alternative protocol has been applied to symmetric Suzuki reactions employing simple electron-rich and electron-poor aryl halide partners, and to sterically challenging Suzuki reactions employing bulkier substrates. Asymmetric (atroposelective) Suzuki coupling

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9

Crepy, Karen Viviane Lucile. "A new asymmetric aryl-aryl coupling reaction and its application to the synthesis of novel liquid crystals." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327498.

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10

Paris, Juraj [Verfasser]. "Combination of Suzuki cross-coupling reaction and biocatalysis in one-pot cascade processes / Juraj Paris." Bielefeld : Universitätsbibliothek Bielefeld, 2019. http://d-nb.info/1206592222/34.

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11

Fodor, Anna. "Heterogeneous metal-catalysed C-C coupling reactions : research and development." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2256/document.

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Des nouveaux catalyseurs bimétalliques à base de palladium et de cuivre ont été développés. Deux voies de préparation ont été testées : l'imprégnation successive (TSI) et la co-imprégnation (CI) en utilisant la zéolithe 4Å (4A) et l'oxyde mixte MgAlxOy comme support. Les catalyseurs ont été caractérisés à l'état frais et testés dans la réaction de couplage Suzuki–Miyaura afin de comparer leurs activités, sélectivités et stabilités. L'étude de stabilité nous a montré que le catalyseur Cu-Pd-4A-TSI restait actif pendant six cycles alors que l'activité du catalyseur Cu-Pd-4A-CI diminuait. Sur le

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12

Payard, Pierre-Adrien. "Mechanistic studies of metal-catalyzed reactions : predicting tools for reaction optimization." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEE009/document.

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Cette thèse est consacrée à l’étude de mécanismes de réactions catalysées par des métaux ainsi qu’au développement de nouveaux outils pour la rationalisation et la prévision du comportement catalytique. L’étape de transmétallation entre le bore et le nickel a été étudiée en détail à l’aide de méthodes expérimentales variées (electrochimie, RMN, cinétiques) et par DFT, permettant d’expliquer certaines limitations rencontrées par les experimentateurs. La seconde partie de cette thèse est dédiée à la rationalisation du comportement d’une famille d’acides de Lewis : les sels de triflate et de trif

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13

Brinkley, Kendra W. "The Synthesis of Solid Supported Palladium Nanoparticles: Effective Catalysts for Batch and Continuous Cross Coupling Reactions." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3959.

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Catalysis is one of the pillars of the chemical industry. While the use of catalyst is typically recognized in the automobile industry, their impact is more widespread as; catalysts are used in the synthesis of 80% of the US commercial chemicals. Despite the improved selectivity provided by catalyst, process inefficiencies still threaten the sustainability of a number of synthesis methods, especially in the pharmaceutical industry. Recyclable solid supported catalysts offer a unique opportunity to address these inefficiencies. Such systems coupled with continuous synthesis techniques, have the

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14

Yang, Yuan. "Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5488.

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Palladium-catalyzed carbon-carbon cross-coupling reactions have emerged a broadly useful, selective and widely applicable method to synthesize pharmaceutical active ingredients. As currently practiced in the pharmaceutical industry, homogeneous Pd catalysts are typically used in cross-coupling reactions. The rational development of heterogeneous catalysts for cross-coupling reactions is critical for overcoming the major drawbacks of homogeneous catalysis including difficulties in the separation, purification, and quality control process in drug production. In order to apply heterogeneous catal

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15

Alrawashdeh, Albara I. S. "From Mono- to Tetraphosphines – A Contribution to the Development of Improved Palladium Based Catalysts for Suzuki- Miyaura Cross Coupling Reaction." Doctoral thesis, Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-80110.

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Im ersten Teil der Arbeit wird die Synthese neopentyl- und neosilylsubstituierter Phosphane zur Verwendung als Liganden in katalytisch aktiven Palladiumkomplexen beschrieben. Die Aktivität wurde in der Suzuki-Miyaura Kreuzkupplungsreaktion getestet. Während die neosilylsubstituierten Phosphane 2:1 Addukte (5b und 5d) mit geeigneten Palladiumsalzen bilden, welche moderate Katalyseaktivität zeigen, untergehen die neopentylsubstituierten Komplexe schnelle Cyclometalierungsreaktionen in Gegenwart von Basen und bilden die katalytisch wenig aktiven Palladacyclen (6a, 6e, and 6g). Die deaktivierende

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16

Green, Anthony Laine. "The Directed ortho Metalation of pyridine derivatives with in situ boronation and links to the Suzuki-Miyaura cross coupling reaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63310.pdf.

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17

François, Benjamin. "Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S114.

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Les composés organoborés constituent des outils remarquables en synthèse organique de par leur chimie très diversifiée. Les travaux présentés dans ce mémoire abordent de nouveaux aspects de leur réactivité. Une méthode de synthèse rapide et efficace de 9-hydroxyfluorènes est décrite via une séquence tandem Suzuki/ aldolisation phénolique. Ce processus a été ensuite étendu aux 9-aminofluorènes en ajoutant simplement comme troisième partenaire diverses amines au milieu réactionnel. Des hypothèses mécanistiques sont proposées pour rationaliser ces résultats expérimentaux. Dans une deuxième partie

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18

Hussain, Jakir. "Approaches toward the synthesis of lactonamycin utilising a new benzannulation reaction." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/approaches-toward-the-synthesis-of-lactonamycin-utilising-a-new-benzannulation-reaction(1157cbe4-21f4-4d9e-a10d-cf20518eb30b).html.

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The Bull-Hutchings-Quayle (BHQ) reaction is a novel method for the synthesis of 1-(bromo/chloro)napthalenes from 2-allyphenyl-2’,2’,2’-tri(bromo/chloro)acetates. The reaction is also known as Atom Transfer Radical Cyclisation-Benzannulation (ATRC-Benzannulation). The ATRC-Benzannulation of structurally diverse 2-(cyclohex-1-en-1-ylmethyl)phenyl 2’,2’,2’-trichloroacetates in the presence of 1,3bis-(2,6diisopropylphenyl)imidazolium copper(I) chloride [“Nolan NHC-CuCl”] complexes, using microwave or thermolytic methods, afford a range of 9-chloro-1,2,3,4-tetrahydroanthracenes. Efficient ATRC-Be

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19

Peramo, Arnaud. "Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée PLGA-PEG-supported Pd nanoparticles as efficient catalysts for Suzuki-Miyaura coupling reactions in water Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles A Self-Assembling Palladium-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-coupling Reaction in Water." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS600.

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Les nanotechnologies ont ouvert de nouvelles perspectives pour l’administration ciblée des médicaments. Les approches actuelles en nanomédecine sont basées sur l’encapsulation d’un principe actif dans un nano-vecteur. Nous proposons dans ce travail l’utilisation de nanoparticules non plus pour adresser un médicament encapsulé vers sa cible, mais pour manipuler une protéine d’intérêt en milieu biologique, ce qui constitue une nouvelle stratégie thérapeutique. Avec cet objectif, nous avons identifié une formulation de nanoparticules de palladium, stable, non toxique et dotée d’un pouvoir catalyt

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20

屋木, 祐亮. "肝臓の有機アニオントランスポーター機能のインビボ評価のための核医学分子イメージングプローブの開発に関する研究". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192150.

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21

Arvela, Riina K. "Palladium-Catalysed Carbon–Carbon Coupling Reactions : Focusing on Microwave Heating, Low Catalyst Concentrations, Aqueous Conditions, Regioselectivity and Medicinal Chemistry Applications." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99776.

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22

D'Attoma, Joseph. "Conception, synthèses et évaluations biologiques d’inhibiteurs à double cible : ALK et la restriction calorique." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10243.

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Les lymphomes à grandes cellules anaplasiques ou ALCL (Anaplastic Large-Cell Lymphoma) sont des cancers appartenant à la famille des lymphomes de type non-Hodgkin. La majorité des ALCL est issue d'une translocation t(2;5)(p23;q35) donnant lieu à la formation d'une protéine de fusion appelée NPM-ALK. A ce jour, peu d'inhibiteurs présentent de bonnes activités contre cette protéine chimérique. L'obésité représente un problème socio-médical d'envergure, à la fois pour ses effets directs et indirects ; le surpoids étant un facteur primaire dans de nombreuses maladies, tout particulièrement les dia

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23

Trejos, Alejandro. "Palladium-Catalysed Couplings in Organic Synthesis : Exploring Catalyst-Presenting Strategies and Medicinal Chemistry Applications." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173068.

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Palladium-catalysed coupling reactions have been embraced by synthetic chemists as one of the preferred means for smooth formation of new carbon-carbon bonds: a truly ubiquitous methodology of synthesizing complex molecules. This thesis describes the study of a series of palladium(0)-catalysed C2-arylations of a 1-cyclopentenyl ether, equipped with a chiral (S)-N-methyl-pyrrolidine auxiliary. The investigated olefin was demonstrated to undergo Si-face insertion, providing (R)-configuration of the arylated C2-carbon. In addition, the mild and novel palladium(II)-catalysed dominoHeck/Suzuki β,α-

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24

Heidemann, Sven. "Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C16-4.

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25

Alrawashdeh, Albara I. S. [Verfasser], Heinrich [Akademischer Betreuer] Lang, Heinrich [Gutachter] Lang, and Wolfgang [Gutachter] Weigand. "From Mono- to Tetraphosphines – A Contribution to the Development of Improved Palladium Based Catalysts for Suzuki- Miyaura Cross Coupling Reaction / Albara I. S. Alrawashdeh ; Gutachter: Heinrich Lang, Wolfgang Weigand ; Betreuer: Heinrich Lang." Chemnitz : Universitätsbibliothek Chemnitz, 2011. http://d-nb.info/1214008410/34.

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26

Ramoroka, Morongwa Emmanuel. "Photophysics of Thiophenosalicylaldimine-functionalized G1-Polyprolyleniminato-Copper Telluride/Antimonide core-shell Nanomaterials." University of the Western Cape, 2018. http://hdl.handle.net/11394/6262.

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Magister Scientiae - MSc (Chemistry)<br>This work involves the synthesis of copper telluride-polypropylenimine tetra(5-(2-thienyl) salicylaldimine) (CuTe@PPI) and copper antimonide-polypropylenimine tetra(5-(2-thienyl) salicylaldimine) (CuSb@PPI) core-shell nanoparticles (NPs), using two-pots and one-pot synthesis methods, respectively. Their morphology was studied by X-ray diffraction spectroscopy (XRD), high resolution transmission electron microscopy (HRTEM) and high resolution scanning electron microscopy (HRSEM); while their structures were characterized by Fourier transform infrared spec

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27

Korb, Marcus. "Anionic Phospho-Fries Rearrangements for the Synthesis of Planar-Chiral Ferrocenes and their Application in (atropselective) Suzuki-Miyaura Reactions." Doctoral thesis, Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-229081.

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The present PhD thesis describes the synthesis and characterization of novel planarchiral 1,2-P,O-ferrocenes and their application in the Pd-catalyzed Suzuki-Miyaura reaction. It was especially focused on the development of a new synthetic pathway to this type of substitution pattern by applying the anionic phospho-Fries rearrangement in ferrocene chemistry. Starting from hydroxy ferrocene, a high diversity of Fc–O–P- type (Fc = (n5-C5H5)(n5-C5H4)) compounds were synthesized, whereby the electronic properties of the phosphorus fragments were varied. The anionic phospho-Fries rearrangement succ

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28

Sommer, William J. "Supported catalysts, from polymers to gold nanoparticles supports." Diss., Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-07062007-225935/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2008.<br>Christoph J. Fahrni, Committee Member ; Mostapha A. El-Sayed, Committee Member ; Christopher W. Jones, Committee Member ; Marcus Weck, Committee Chair ; E. Kent Barefield, Committee Member.

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29

Smith, Paul James. "Palladium catalysed Suzuki cross-coupling reactions in ambient temperature ionic liquids." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405785.

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30

Milde, Bianca. "(Ethynyl-)Ferrocenyl Phosphine Palladium Complexes and (Bis-)Phosphinoimidazol(e/ium) Compounds and their Application in Homogeneous Catalysis." Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-90521.

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Die vorliegende Dissertation beschäftigt sich mit der Synthese, der Charakterisierung und der Anwendung neuartiger Phosphane in homogenkatalytischen Reaktionen. Dabei wurden die Ferrocenyl- und Ferrocenylethinylphosphan-Palladium und Ferrocenylethinylphosphan-Ruthenium Komplexe in der Palladium-vermittelten Mizoroki-Heck- und Suzuki-Miyaura-Reaktion sowie der Ruthenium-katalysierten Synthese von β-Oxopropylestern verwendet. Der Schwerpunkt lag dabei auf der Untersuchung des Einflusses der elektronischen und räumlichen Eigenschaften der Phosphanliganden auf die Aktivität und Produktivität der e

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31

Diebold, Carine. "Developpement de nouveaux catalyseurs au palladium supporté sur polymères ou nanoparticules de cobalt : application à la formation de liaisons carbone-carbone." Phd thesis, Université de Haute Alsace - Mulhouse, 2012. http://tel.archives-ouvertes.fr/tel-00807363.

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Les réactions pallado-catalysées permettant la formation de liaisons carbone-carbone trouvent de nombreuses applications en synthèse organique et constituent l'étape clé de la synthèse d'un grand nombre de molécules. La première partie de cette thèse décrit la préparation et l'étude de catalyseurs hétérogènes et réutilisables comportant du palladium supporté sur un polymère portant des groupements phosphinés, polymère dérivé soit d'une résine de Merrifield soit d'une résine Rasta. De très bons résultats ont été obtenus pour leur utilisation dans les couplages croisés de Hiyama, Heck et Suzuki

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32

Eriksson, Ludvig. "Transition Metal Mediated Transformations of Carboranes." Doctoral thesis, Uppsala University, Organic Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3324.

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<p>This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially <i>p</i>-carborane.</p><p>1-(1-<i>p</i>-carboranyl)-<i>N</i>-methyl-<i>N</i>-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. A key step in the reaction is the copper (I) mediated coupling of p-carborane with ethyl 1-bromo-isoquinoline-3-carboxylate. </p><p><i>p</i>-Carborane has been arylated on the 2-<i>B</i>-atom in high yields, using the Suzuki–Miyaura reaction. Thus the reacti

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Keith, Adam J. "Ion-tagged Phosphines for Catalytic Reactions in Ionic Liquids." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1407960203.

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Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t

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Adidou, Ouissam. "Ligands dérivés de saccharides et, ou supportés par un bras poly(éthylène) glycol : synthèse et applications en catalyse organométallique." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10171.

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La synthèse de deux familles de ligands a été envisagée. La première famille de ligands concerne la préparation de nouveaux ligands dérivés de la D-glucosamine ou du D-glucose qui seront engagés dans la réaction de substitution allylique de type Tsuji-Trost en phase homogène. La deuxième famillede ligands concerne la préparation de ligand supportés par un bras poly(éthylène) glycol et dérivés dela D-glucosamine ou de la di-(2-pyridyl)méthylamine. Ces ligands hydrosolubles ont été engagés dans deux réactions pallado-catalysées en phase aqueuse à savoir la substitution allylique de type Tsuji-Tr

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Zhang, Wanying. "A Mechanistic Approach Towards the Discovery of Catalytic Acylation Reactions." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35646.

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The development of new, efficient methods for the formation of carbon-carbon bonds using transition metal catalysis has broad applications in the field of organic chemistry and is the key to efficient chemical synthesis. Many efforts had been made to develop efficient ways to make these linkages particularly with the aid of metals such as Rh, Pd, Ni, Ru and Cu. Our group is primarily focused on exploring how these transition metals can activate typically inert functional groups, paving way to new synthetic routes to construct more complex molecules. Chapter 1 describes attempts that were cond

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37

Allouch, Fatima. "Synthèse et applications de nouveaux complexes métallocéniques multidentes." Thesis, Dijon, 2013. http://www.theses.fr/2013DIJOS002.

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Ce mémoire porte sur l’accès simple et peu coûteux à de nouveaux ligands ferrocéniques aminés et aminophosphinés et leur coordination avec des métaux de transition pour des applications en catalyse homogène.Des métallo-ligands aminés flexibles ont été obtenus et caractérisés après amination réductrice du 1,1’-diformylferrocène. D’autres ligands (N,N) rigides ont été isolés au départ du précurseur du 1,1’-di-tert-butyl-3,3’-diformylferrocène. Des aza-ferrocénophanes ont également été facilement préparés avec ces deux précurseurs carbonylés. Lors de la coordination de ces ligands avec le palladi

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Chamoin, Sylvie. "Aryl-aryl Stille and Suzuzi-Miyaura cross-coupling reactions on solid support." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0022/NQ51184.pdf.

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39

Ben, Halima Taoufik. "Engaging Esters as Cross-Coupling Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39493.

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Cross-coupling reactions, where a transition metal catalyst facilitates the formation of a new carbon-carbon or carbon-heteroatom bond between two coupling partners, has become one of the most widely used, reliable, and robust family of transformations for the construction of molecules. The Nobel Prize was awarded to pioneers in this field who primarily used aryl iodides, bromides, and triflates as electrophilic coupling partners. The expansion of the reaction scope to non-traditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simp

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Funk, Sebastian [Verfasser], Jürgen [Akademischer Betreuer] Schatz, Jürgen [Gutachter] Schatz, and Evgeny [Gutachter] Kataev. "Pillararenes as Supramolecular Additives in Suzuki Cross-Coupling and Olefin Metathesis Reactions in Water / Sebastian Funk ; Gutachter: Jürgen Schatz, Evgeny Kataev ; Betreuer: Jürgen Schatz." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1221370359/34.

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Naas, Mohammed. "Synthèse et fonctionnalisation de nouveaux dérivés d’indazoles à visée thérapeutique." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2009/document.

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L’accès à de nouveaux composés hétérocycliques originaux biologiquement actifs nécessite la mise au point de nouvelles méthodes de synthèse rapides et efficaces. Dans ce contexte, nous nous sommes intéressés à la réactivité des indazoles. Dans la première partie, nous avons étudié la sélectivité des couplages de type Suzuki, pour fonctionnaliser la position 3 d’indazoles possédant la fonction NH libre. Par la suite, un nouveau procédé d’(hétéro)arylation direct pallado-catalysé régiosélectif a été mis à profit pour synthétiser des indazoles fonctionnalisés tant sur la position 3 que sur le som

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Pareek, Manish [Verfasser], Martin [Akademischer Betreuer] Oestreich, Martin [Gutachter] Oestreich, and Philipp [Gutachter] Heretsch. "Activation of boron–boron, tin–silicon, and tin–tin bonds : application in carbon–element (E = B and Sn) bond-forming reactions and site-selective Suzuki–Miyaura cross-coupling reactions / Manish Pareek ; Gutachter: Martin Oestreich, Philipp Heretsch ; Betreuer: Martin Oestreich." Berlin : Technische Universität Berlin, 2017. http://d-nb.info/1156016843/34.

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Le, Meur Mikaël. "Identification de nouveaux inhibiteurs de l’agrégation de la protéine Tau." Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE2046.

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Parmi la vingtaine de pathologies neurodégénératives recensées à ce jour, il a été retrouvé des caractéristiques communes telles que des lésions neuronales. Dans le cas de la Maladie d’Alzheimer, une dégénérescence neurofibrillaire a notamment été mise en évidence, ce qui se traduit par l’agrégation de protéines Tau anormalement modifiées. Bien que les mécanismes moléculaires impliqués demeurent encore mal compris, nous nous sommes intéressés, au cours de cette thèse, à la synthèse puis à l’évaluation biologique de nouveaux inhibiteurs de l’agrégation de la protéine TAU impliquée dans la Malad

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Fersing, Cyril. "Synthèse et étude des relations structure-activité de nouvelles 3-nitroimidazo (1,2-a) pyridines anti-kinétoplastidés." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0275/document.

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Les maladies tropicales négligées causées par les protozoaires kinétoplastidés du genre Leishmania et Trypanosoma représentent une menace pour près d’un demi-milliard de personnes en zone intertropicale, entrainant jusqu’à 50 000 décès par an. Parmi les molécules en développement clinique pour traiter ces pathologies, le fexinidazole est une prodrogue appartenant à la famille des 5-nitroimidazoles et qui exerce son action anti-infectieuse via une étape de bioactivation catalysée par des nitroréductases (NTR) parasitaires, enzymes dont le co-facteur est une flavine. Afin d’identifier de nouveau

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Mitchell, Emily. "Studies In the Optimization of the Suzuki-Miyaura Reaction." Thesis, 2008. http://hdl.handle.net/1974/1612.

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Enormous efforts have been made to optimize the Pd-catalyzed Suzuki-Miyaura reaction, but there is to date no generally useful protocol and forcing conditions are often required. One reaction variable that has often been neglected is the extent to which the supposed catalysts, bisphosphinepalladium(0) complexes, are actually formed from the variety of popular precatalysts used. There is in fact little evidence that these precursors produce bis-ligated Pd(0) complexes and it is possible that the rate limiting factor may be catalyst formation. If so, then the development of an optimized method

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Lin, Joseph C. Y., and 林樵揚. "Ionic Liquid Crystal Stabilized Palladium Nanoparticles: Excellent Catalyst for Suzuki Coupling Reaction." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/58193234757179841266.

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博士<br>國立東華大學<br>化學系<br>99<br>The present thesis researches on the properties and applications for nanomaterials and new ionic liquid crystals. The contents include one introduction, five chapters, and appendixes. Introduction reviews the backgrounds of nanotechnology and liquid crystal. Chapter 1 is mainly on the studies of synthesis and characterization of palladium nanocubes and their excellent catalytic activity on Suzuki coupling reactions. The investigation of the imidazolium salt as a stabilizer forming a bilayer structure and lability on the Pd surface has also been examined and dis

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Chen, Chuan-Lin, and 陳傳霖. "Substituent Effect on Cyclopalladation of Arylimine Ligands Applied for Suzuki-Miyaura Coupling Reaction." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/84490813805942089652.

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博士<br>國立臺灣大學<br>化學研究所<br>92<br>A series of substituted benzylidene- and dialkylarylamines reacted with PdCl2(CH3CN)2 under basic conditions at the room temperature to provide the desired cyclopalladated products (13a-i and 14j-m), even the halo substituted (Le and Lf) arylimines. The steric bulky substituent such as t-butyl on the aryl rings readily inhibits the C-H activation and only yields the simple imine-coordinated complexes (15g and 15g’, 15h). As expected, cyclometallation takes place at the ortho position of the aryl ring resulting in formation of a five-membered chelating ring. Howev

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Wang, Meng-Pei, and 王孟珮. "The Development of Novel Benzimidazolylindole-scaffold Ligands and Their Applications in Suzuki-Miyaura Coupling Reaction." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/02203407971141139644.

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碩士<br>國立中興大學<br>化學系所<br>104<br>Suzuki-Miyaura coupling reaction has played an important role in the synthesis of biaryl compounds. Unfortunately, most of them require the use of air and/or thermally labile phosphine ligands. How to improve the ligand stability and to reduce the amount of catalyst needed has been one of the important synthetic issues. This research has synthesized a series of novel C,N-ligands 17, 20 comprising indole and benzimidazole rings starting from commercially available phenyl diamine and indole 2-carboxylic acid. The Suzuki cross-coupling reaction of functionalized

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Wei, Liu Xiang, and 劉享瑋. "Synthesis of Zwitterionic Palladium Complex and their Applicationin in Room Temperature Suzuki Cross-Coupling Reaction." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/36946782130145303784.

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碩士<br>國立彰化師範大學<br>化學系<br>103<br>A series of new imidazolium chlorides were straightforwadly prepared from the reactions between chloroacetone and imidazo[1,2-a]pyridine derivatives. Deprotonation of the methylene proton next to the ketone group in these salts by pyridine led to the formation of a monodentate ligand that coordinated to palladium readily forming zwitterionic anionic palladium pyridine complexes bearing a formal positive charge on the ligand ancillary. The pyridine ligand in the zwitterionic complexes can be replaced by phosphine ligands. Some of these new complexes were successf

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Gao, Zing-Lun, and 高政論. "Effect of Orthometallation on NHC Palladium Complexes on the Catalytic Activity Studies in Suzuki Coupling Reaction." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/rde578.

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碩士<br>靜宜大學<br>應用化學系<br>105<br>This work helps to understand how to improve catalytic activities for cross-coupling reaction. N-heterocyclic carbene (NHC) palladium complexes bearing nitrogen-based ligand without orthometallation show remarkable activities than with orthometallation one in Suzuki coupling reaction. All complexes are characterized by single X-ray diffraction as well as 1H and 13C NMR spectroscopy. From catalytic studies, without orthometallation NHC palladium complexes exhibit shorter pre-activation time to achieve very good activity results in Suzuki coupling reaction when aryl

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