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Dissertations / Theses on the topic 'Suzuki Coupling'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Daku, Kokovi Lawson. "Applications of the Suzuki cross coupling reaction." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425882.

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2

Hashimoto, Toru. "Development of Iron-Catalyzed Suzuki-Miyaura Coupling Reaction." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/159407.

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3

Geogheghan, Katherine Jayne. "Boronic acid speciation in Suzuki-Miyaura cross-coupling." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33092.

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Since its discovery in 1979, the Suzuki-Miyaura (SM) reaction has become one of the most widely utilised tools for carbon-carbon bond formation. The palladium catalysed coupling of an organoboron and organohalide compounds proceeds through a three-stage mechanism of oxidative addition, transmetalation and reductive elimination. The transmetalation of boronic acids to a palladium(II) complex has been widely studied. However, very little is known about the transmetalation of boronic esters, which are commonly used as an alternative to unstable boronic acids. Whether these species undergo direct

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4

Fyfe, James William Buchanan. "Chemoselective Suzuki-Miyaura cross-coupling enabled by speciation control." Thesis, University of Strathclyde, 2017. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27909.

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Boronic acids and esters are one of the most widely used compound classes inorganic chemistry. Recently, diboron systems have emerged as a powerful approach towards complex molecule synthesis. Selectivity in these systems is typically achieved through the use of protecting group strategies in which one boron residue is rendered unreactive under the prevailing reaction conditions, allowing selective manipulation of an unprotected unit. However, while these methods offer excellent selectivity, they do have the drawback of requiring additional synthetic manipulations, i.e., removal of the protect

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5

Hassanzadeh, Nazanin. "Suzuki reactions in novel liquids." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-106739.

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Non-ionic deep eutectic solvent (ni-DES) possesses various advantages such as good solvation, biodegradability, and non-toxicity which makes it a perfect and environmentally friendly solvent for organic synthesis. A Pd (OAc)2 catalyzed, Suzuki reaction of aryl bromide and N-heteroaryl halide with arylboronic acid in green and novel solvent (ni-DES) is described. In this work, the possibility of using ni-DES and the impact of this solvent on the scope of the reaction is studied. It is illustrated that using the mixture of N-alkyl derivatives of urea and acetamide as a green solvent for Suzuki r

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6

Elmalem, Einat. "Synthesis of π-conjugated polymers via Suzuki cross-coupling polymerization". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608242.

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7

Kuvayskaya, Anastasia, and Aleksey Vasiliev. "Use of Suzuki Coupling Reaction for Synthesis of Functionalized Materials." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/162.

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Hybrid materials synthesized by grafting of organic molecules onto silica surface have found numerous applications in chemistry, biochemistry, and chemical engineering. In particular, the functionalization of silica gel can be accomplished by various surface reactions of immobilized boronic acids. Suzuki coupling has been chosen due to several advantages, such as mild reaction conditions, tolerance to the aqueous environment, and high yields of the products. The objective of this work was to determine the most effective reaction conditions for modifying porous hybrid materials with large speci

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8

Andert, William D. "Palladium Catalyzed Suzuki-Miyaura Cross-Coupling of Axially Chiral Biaryls." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1367536419.

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9

Smith, Paul James. "Palladium catalysed Suzuki cross-coupling reactions in ambient temperature ionic liquids." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405785.

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10

Baltus, Christine B. "Suzuki-Miyaura mediated biphenyl synthesis : a spotlight on the boronate coupling partner." Thesis, University of Greenwich, 2011. http://gala.gre.ac.uk/8038/.

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The biaryl motif is found in many natural and synthetic products that display a wide range of biological activities. This explains why biphenyls are widely encountered in medicinal chemistry as a privileged scaffold. The palladium-catalysed Suzuki-Miyaura (SM) coupling is one of the most important and efficient strategies for the synthesis of symmetrical and unsymmetrical biaryl compounds; the arylboronic acid or ester is a key partner in this coupling reaction. This work presents the synthesis of a library of new molecules containing the biphenyl scaffold; o-, m- and p-(bromomethyl)phenylboro

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11

Sarkar, B. R. "Studies in carbonylation and suzuki coupling reactions using immobilzed palladium complex catalysts." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2566.

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12

Crepy, Karen Viviane Lucile. "A new asymmetric aryl-aryl coupling reaction and its application to the synthesis of novel liquid crystals." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327498.

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13

Todd, Matthew H. "Novel encoding strategies for combinatorial chemistry." Thesis, University of Cambridge, 1998. https://www.repository.cam.ac.uk/handle/1810/272807.

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14

Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t

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15

Watts, Nicola Louisa. "Improving the scope and understanding of the Symmetric and Asymmetric Suzuki coupling reaction." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/48116/.

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Investigations into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and stoichiometrically efficient process. This alternative protocol has been applied to symmetric Suzuki reactions employing simple electron-rich and electron-poor aryl halide partners, and to sterically challenging Suzuki reactions employing bulkier substrates. Asymmetric (atroposelective) Suzuki coupling

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16

Heaner, William. "Indole synthesis: Knoevenagel/Hemetsberger reaction sequence; Suzuki coupling reactions of basic nitrogen containing substrates." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52171.

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A series of substituted indoles have been synthesized by the sequential reaction of aromatic aldehydes with ethyl azidoacetate in the presence of sodium ethoxide to form the corresponding ethyl α-azido-β-arylacrylates (Knoevenagel process) followed by a solvent mediated thermolysis (Hemetsberger process). The isolated yields of the ethyl α-azido-β-arylacrylates were significantly increased when employing the sacrificial electrophile ethyl trifluoroacetate. 1H NMR and coupled 1H-13C NMR analysis of the ethyl α-azido-β-arylacrylates indicate that the condensation is stereospecific—only the Z

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17

Chang, Weng Kun. "Development of Tandem Reaction for Synthesis of Highly Functionalized Carbocycles." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104067.

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Thesis advisor: James P. Morken<br>The Suzuki-Miyaura cross-coupling reaction is a common strategy for the formation of a new carbon-carbon bond in organic synthesis. However, intramolecular coupling of allylboron ester and aryl electrophiles has never been reported. Herein, Pd-catalyzed intramolecular cross-coupling of allylboronic pinacol ester and vinyl or aryl bromides is presented. Pt-catalyzed 1,2-diboration of 1,3-dienes give α-chiral bis-allylboronic esters, which can undergo diastereoselective additions to carbonyl electrophiles tethered to vinyl or aryl halides to generate a new ally

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18

Keith, Adam J. "Ion-tagged Phosphines for Catalytic Reactions in Ionic Liquids." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1407960203.

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19

Ben, Halima Taoufik. "Engaging Esters as Cross-Coupling Electrophiles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39493.

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Cross-coupling reactions, where a transition metal catalyst facilitates the formation of a new carbon-carbon or carbon-heteroatom bond between two coupling partners, has become one of the most widely used, reliable, and robust family of transformations for the construction of molecules. The Nobel Prize was awarded to pioneers in this field who primarily used aryl iodides, bromides, and triflates as electrophilic coupling partners. The expansion of the reaction scope to non-traditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simp

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20

Kendall, Christopher Nicholas Owen. "The directed ortho metalation - Suzuki-Miyaura cross-coupling connection, towards the total synthesis of dehydrorabelomycin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0020/MQ54462.pdf.

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21

Paris, Juraj [Verfasser]. "Combination of Suzuki cross-coupling reaction and biocatalysis in one-pot cascade processes / Juraj Paris." Bielefeld : Universitätsbibliothek Bielefeld, 2019. http://d-nb.info/1206592222/34.

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22

Fodor, Anna. "Heterogeneous metal-catalysed C-C coupling reactions : research and development." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2256/document.

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Des nouveaux catalyseurs bimétalliques à base de palladium et de cuivre ont été développés. Deux voies de préparation ont été testées : l'imprégnation successive (TSI) et la co-imprégnation (CI) en utilisant la zéolithe 4Å (4A) et l'oxyde mixte MgAlxOy comme support. Les catalyseurs ont été caractérisés à l'état frais et testés dans la réaction de couplage Suzuki–Miyaura afin de comparer leurs activités, sélectivités et stabilités. L'étude de stabilité nous a montré que le catalyseur Cu-Pd-4A-TSI restait actif pendant six cycles alors que l'activité du catalyseur Cu-Pd-4A-CI diminuait. Sur le

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23

Zhang, Wanying. "A Mechanistic Approach Towards the Discovery of Catalytic Acylation Reactions." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35646.

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The development of new, efficient methods for the formation of carbon-carbon bonds using transition metal catalysis has broad applications in the field of organic chemistry and is the key to efficient chemical synthesis. Many efforts had been made to develop efficient ways to make these linkages particularly with the aid of metals such as Rh, Pd, Ni, Ru and Cu. Our group is primarily focused on exploring how these transition metals can activate typically inert functional groups, paving way to new synthetic routes to construct more complex molecules. Chapter 1 describes attempts that were cond

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24

Ingner, Fredric. "Suzuki coupling of functionalized arylboronic acids to a 2-Amino-5-(4-bromophenyl)-1,3,4-thiadiazole scaffold." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-247573.

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25

Crockett, Michael. "TheDevelopment of Iron Catalysts for Suzuki-Miyaura Cross-Coupling and the Reactivity Discovered Along the Way:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108946.

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Thesis advisor: Jeffery A. Byers<br>This dissertation discusses the development of iron-based catalysts for Suzuki-Miyaura cross-coupling reactions and some of the unique reactivity that was discovered as a direct result of these studies. Chapter one will review the area of iron-catalyzed cross-coupling with an emphasis placed on areas where iron provides complimentary reactivity to other metals. Chapter two will detail the initial discovery of conditions that allow for iron-catalysts to participate in the cross-coupling of aryl boronic esters and alkyl halides. Chapter three will discuss the

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26

Lai, Ping-Shan. "Directed ortho metalation-boronation Suzuki-Miyaura cross coupling leading to synthesis of azafluorenol core liquid crystals." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/511.

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27

Mlynarski, Scott Nathan. "Utilizing Terminal Alkenes in Asymmetric Synthesis: Development and Application of Efficient Diboration/Cross-Coupling Cascades." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:103555.

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Thesis advisor: James P. Morken<br>The first highly enantioselective diboration of unfunctionalized terminal alkenes has been developed using a platinum-phosphonite complex. This transformation produces versatile 1,2-bis(boronate)esters that can manipulated chemoselectively to generate a pletheroa of enantioenriched structural motifs. When combined with an appropriate palladium catalyst, the diboration product undergoes an efficient alkyl boron cross-coupling with aryl and vinyl electrophiles producing a wide range of enantioenriched homobenzylic and homoallylic boronates. Alternatively, when

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28

Schäfer, Philipp. "Enantioselective synthesis of chiral building blocks with non-stabilized nucleophiles." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:d69d1861-5368-495a-932d-7e1aa6bc5dfb.

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This thesis describes the combination of non-stabilized nucleophiles and prochiral/racemic electrophiles in transition metal catalyzed asymmetric transformations. These enantioselective reactions have tremendous potential for the formation of chiral building blocks and new structural motifs that can be found in a variety of natural products and their derivatives. The first part of the thesis focuses on the synthetic approach towards anti-cancer active diterpenoid structures. The two key steps involve a Cu-catalyzed asymmetric conjugate addition of alkylzirconocenes to enones and an intramolecu

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29

Yang, Yuan. "Graphene as a Solid-state Ligand for Palladium Catalyzed Cross-coupling Reactions." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5488.

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Palladium-catalyzed carbon-carbon cross-coupling reactions have emerged a broadly useful, selective and widely applicable method to synthesize pharmaceutical active ingredients. As currently practiced in the pharmaceutical industry, homogeneous Pd catalysts are typically used in cross-coupling reactions. The rational development of heterogeneous catalysts for cross-coupling reactions is critical for overcoming the major drawbacks of homogeneous catalysis including difficulties in the separation, purification, and quality control process in drug production. In order to apply heterogeneous catal

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30

Zhang, Ye. "Development of amide-derived P,O-ligands for Suzuki cross-coupling of aryl chlorides and the asymmetric version /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20ZHANG.

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31

François, Benjamin. "Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S114.

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Les composés organoborés constituent des outils remarquables en synthèse organique de par leur chimie très diversifiée. Les travaux présentés dans ce mémoire abordent de nouveaux aspects de leur réactivité. Une méthode de synthèse rapide et efficace de 9-hydroxyfluorènes est décrite via une séquence tandem Suzuki/ aldolisation phénolique. Ce processus a été ensuite étendu aux 9-aminofluorènes en ajoutant simplement comme troisième partenaire diverses amines au milieu réactionnel. Des hypothèses mécanistiques sont proposées pour rationaliser ces résultats expérimentaux. Dans une deuxième partie

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32

Check, Casey. "Design, Synthesis and Characterization of Two-Dimensional Polyelectrolytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1291397084.

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33

De, Simone Rosa. "Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products." Doctoral thesis, Universita degli studi di Salerno, 2011. http://hdl.handle.net/10556/150.

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2009 - 2010<br>Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; in fact it is over-expressed in several inflammatory disorders[1] as well as in some human tumours.[2;3] Hence, the inhibition of mPGES-1 has been proposed as a promising approach for the development of safer drugs in inflammatory disorders, devoid of classical NSAID side effects.[4] Indeed, this enzyme is responsible for the biosynthesis of inducible PGE2 as a r

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34

Schaarschmidt, Dieter. "Über chirale Phosphinoferrocene und deren Anwendung in der (atropselektiven) Synthese räumlich gehinderter Biaryle über eine Suzuki-Miyaura-Reaktion." Doctoral thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-158105.

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Die vorliegende Dissertation beschäftigt sich mit der Synthese und Charakterisierung drei verschiedener Typen chiraler Phosphinoferrocene sowie deren Anwendung in der Palladiumkatalysierten Suzuki-Miyaura-Reaktion. Der Schwerpunkt liegt dabei auf Untersuchungen zur Synthese räumlich gehinderter Biaryle sowie auf atropselektiven Biarylkupplungen. Über eine Ullmann-artige Kupplung von Iodferrocen mit sekundären Alkoholen wurden zunächst chirale Ferrocenylalkylether synthetisiert, die mit Hilfe dirigierter Lithiierungen in 1,1'-disubstituierte Phosphinoferrocene der Art Fe( 5-C5H4OR)( 5-C5H4-C6H4

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35

Alrawashdeh, Albara I. S. "From Mono- to Tetraphosphines – A Contribution to the Development of Improved Palladium Based Catalysts for Suzuki- Miyaura Cross Coupling Reaction." Doctoral thesis, Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-80110.

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Im ersten Teil der Arbeit wird die Synthese neopentyl- und neosilylsubstituierter Phosphane zur Verwendung als Liganden in katalytisch aktiven Palladiumkomplexen beschrieben. Die Aktivität wurde in der Suzuki-Miyaura Kreuzkupplungsreaktion getestet. Während die neosilylsubstituierten Phosphane 2:1 Addukte (5b und 5d) mit geeigneten Palladiumsalzen bilden, welche moderate Katalyseaktivität zeigen, untergehen die neopentylsubstituierten Komplexe schnelle Cyclometalierungsreaktionen in Gegenwart von Basen und bilden die katalytisch wenig aktiven Palladacyclen (6a, 6e, and 6g). Die deaktivierende

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36

Green, Anthony Laine. "The Directed ortho Metalation of pyridine derivatives with in situ boronation and links to the Suzuki-Miyaura cross coupling reaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63310.pdf.

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37

Cai, Xiongwei. "Regiospecific synthesis of alkylphenanthrenes using a combined directed ortho metalation, DoM, (Suzuki-Miyaura cross coupling), directed remote metalation, DreM, methodology." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63276.pdf.

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38

Martin, Thibaut. "Etude de nouvelles méthodologies d'hétéroarylation directe de liaison C-Het C-Br en série thiazolique : application à la synthèse de coeurs thiazolylpyridiniques des thiopeptides de la série d." Phd thesis, INSA de Rouen, 2010. http://tel.archives-ouvertes.fr/tel-00577166.

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Face à l'apparition alarmante et continue de résistance massive des bactéries à l'arsenal actuel d'antibiotiques, la recherche de nouveaux agents antibactériens est actuellement un enjeu sociétal de tout premier ordre. Bien que connus depuis plus de 50 ans, les thiopeptides antibiotiques suscitent actuellement un très fort regain d'intérêt de la communauté scientifique internationale en raison de leurs propriétés antibactériennes remarquables, notamment contre les staphylococcus areus résistants à la méthiciline et les enterococci résistants à la vancomycine, impliquées dans de nombreuses infe

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39

Santarsiere, Alessandro. "A new total synthesis of myricanol : the influence of an ene-yne system." Electronic Thesis or Diss., Strasbourg, 2024. https://publication-theses.unistra.fr/public/theses_doctorat/2024/Santarsiere_Alessandro_2024_ED222.pdf.

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L'objectif principal de cette thèse de doctorat est la synthèse totale du myricanol, un composé naturel important aux activités biologiques intéressantes. En particulier, ses remarquables propriétés anti-Alzheimer en font un candidat potentiel pour le traitement de diverses taupathies, car il est capable de réduire les niveaux de protéine Tau qui ont tendance à s'accumuler sous forme phosphorylée dans certaines maladies neurodégénératives.. Actuellement, seules trois synthèses racémiques du (+/-)-myricanol sont rapportées dans la littérature. Tout d'abord, cette thèse vise principalement à exp

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40

Vuoti, S. (Sauli). "Syntheses and catalytic properties of palladium (II) complexes of various new aryl and aryl alkyl phosphane ligands." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286483.

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Abstract Thirty three aryl and aryl alkyl phosphane ligands were prepared and characterized for catalytic purposes. The aryl groups in both types of ligands were modified with alkyl substituents (methyl, ethyl, isopropyl, cyclohexyl, phenyl) or hetero substituents (methoxy, N,N-dimethylaniline, thiomethyl). The alkyl groups directly attached to the phosphorous atom were ethyl, isopropyl or cyclohexyl. Mono- and in some cases also dinuclear palladium (II) complexes of the ligands were prepared and characterized. The syntheses of the palladium complexes are solvent-dependent and afford either mo

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41

Walczak, Matthew C. "Total Synthesis Of Polyene Natural Products Lucilactaene And Gymnoconjugatin: Development Of A Boron-Tin Linchpin." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1206036742.

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42

Bochicchio, Antonella. "Towards the atropo-stereoselective total synthesis of myricanol." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF004/document.

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Le myricanol est un [7,0]-métacyclophane naturel qui appartient à la famille des diarylheptanoïdes cycliques et qui possède des propriétés structurales et biologiques intéressantes (activité anti-Alzheimer ou anticancéreuse). L’objectif de ce travail de thèse est la préparation ambitieuse en voie racémique puis atropostéréosélective du myricanol, rendue délicate de part la tension de cycle existante. Pour se faire, deux nouvelles approches rétrosynthétiques ont été considérées. Une première route racémique a été envisagée et a permis de préparer le macrocycle par le biais d’une réaction de mét

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43

Peramo, Arnaud. "Modification sélective de protéines en milieu biologique par réaction de Suzuki-Miyaura nanocatalysée PLGA-PEG-supported Pd nanoparticles as efficient catalysts for Suzuki-Miyaura coupling reactions in water Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles A Self-Assembling Palladium-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-coupling Reaction in Water." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS600.

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Les nanotechnologies ont ouvert de nouvelles perspectives pour l’administration ciblée des médicaments. Les approches actuelles en nanomédecine sont basées sur l’encapsulation d’un principe actif dans un nano-vecteur. Nous proposons dans ce travail l’utilisation de nanoparticules non plus pour adresser un médicament encapsulé vers sa cible, mais pour manipuler une protéine d’intérêt en milieu biologique, ce qui constitue une nouvelle stratégie thérapeutique. Avec cet objectif, nous avons identifié une formulation de nanoparticules de palladium, stable, non toxique et dotée d’un pouvoir catalyt

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44

Amorim, Ana Catarina de Melo. "Desenvolvimento de métodos catalíticos para a síntese de compostos heterocíclicos biológicamente ativos." Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/26548.

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Esta dissertação centra-se na síntese de compostos heterocíclicos aromáticos tricíclicos, que contêm átomos de nitrogénio, nomeadamente as fenantridinas e as dibenzodiazepinas (DBDAs), as quais apresentam um largo espetro de atividades biológicas. Uma família de fenantridinas foi sintetizada com sucesso, através da sequência reacional de acoplamento cruzado de Suzuki-Miyaura/condensação carbonílica, partindo de ésteres amino-arilborónicos e de 2-bromobenzaldeídos, 2-clorobenzaldeídos e acetofenonas. Foi também estudada uma via para a síntese destes compostos, utilizando iminas como material de

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Bortolotto, Tanize. "Síntese nanoparticulas metálicas estabilizadas por copolímeros em bloco com aplicação em reação de redução e acoplamento de Suzuki." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/10576.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The catalytic activity of hierarchical hybrid structures, formed by metal nanoparticles, M-NPs (AuNPs and PdNPs), synthesized and stabilized by block copolymers, is reported in this present work. The catalytic activity was investigated by the study of nanoparticle size and chemical nature of the block copolymer overlaying the M-NP. To evaluate the chemical structure effect of the polymer on catalytic properties of the hybrid systems, a series of eight distinct polymers was used: poly(ethylene oxide)113-b-poly(glycerol monomethacryl

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Karakus, Melike. "Electrochemical And Optical Properties Of Solution Processable Benzotriazole And Benzothiadiazole Containing Copolymers." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613562/index.pdf.

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2-Dodecyl benzotriazole (BTz) and benzothiadiazole (BTd) containing copolymers poly(4-(2-dodecyl-2H-benzo[d][1,2,3]triazol-4-yl)benzo[c][1,2,5]thiadiazole (P1), poly(4-(5-(2-dodecyl-7-(thiophen-2yl)-2H-benzo[d][1,2,3]triazol-4-yl)thiophen-2-yl)benzo[c][1,2,5] thiadiazole (P2) and poly(4-(5-(2-dodecyl-7-(4-hexylthiophen-2-yl)-2H-benzo[d] [1,2,3]triazol-4-yl) -3-hexylthiophen-2-yl) benzo[c][1,2,5] thiadiazole (P3) were synthesized via Suzuki polymerization. Electrochemical and optical properties of the polymers were analyzed. The fabrication of solar cells were carried out and current density-vo

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Yin, Chunfeng. "Regiospecific synthesis of chlorodihydroxybiphenyls and synthesis of 3,3'-bisaryl substituted BINOLs by combined directed ortho metalation (DoM) and Suzuki-Miyaura cross coupling." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63395.pdf.

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Onuska, Nicholas Paul Ralph. "Studies Towards the Synthesis of 2,5-Disubstituted-3-Fluorothiophenes Using a Directed Ortho-Metalation/Nickel-Catalyzed Cross-Coupling Approach." Kent State University Honors College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1460652408.

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Nagaradja, Elisabeth. "Bases bimétalliques fer-lithium et zinc-lithium pour la fonctionnalisation (hétéro)aromatique : étude comparative et applications en série azolique." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S177/document.

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Le but principal de ce travail a été de mettre en évidence le potentiel synthétique de nouvelles bases mixtes fer-lithium dans des réactions de déprotométallation en série aromatique. Dans un premier chapitre, les travaux de la littérature sur les composés fer-métal alcalin et notamment les bases ont d’abord été exposés. Notre étude a permis d’optimiser une nouvelle base fer-lithium et a montré la capacité de celle-ci à réaliser des réactions de déprotonation relativement chimiosélectives et efficaces. Les paramètres de la réaction de déprotométallation ont été optimisés en utilisant l’iode co

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Delaunay, Thierry. "Synthèses concises de pyrazoles et pyridones diversement fonctionnalisées dans le but d’effectuer des réactions de couplages croisés sélectifs." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10274/document.

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Ce mémoire est subdivise en deux parties. La première partie concerne la synthèse de pyrazoles présentant un intérêt sur le plan agrochimique. En effet, le noyau pyrazole est présent dans de nombreux composes ayant des activités biologiques diverses et en particulier antifongique. Au cours de ce travail, nous avons développé diverses approches convergentes de pyrazoles diversement substitués au moyen de réactions de couplages croisés pallado-catalyses sélectifs et séquentiels à partir de pyrazoles possédant différents points d’encrages. Dans la deuxième partie, nous nous sommes intéressés à la

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