Academic literature on the topic 'Suzuki-Miyaura domino coupling'

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Journal articles on the topic "Suzuki-Miyaura domino coupling"

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Akkarasamiyo, Sunisa, Somsak Ruchirawat, Poonsaksi Ploypradith та Joseph S. M. Samec. "Transition-Metal-Catalyzed Suzuki–Miyaura-Type Cross-Coupling Reactions of π-Activated Alcohols". Synthesis 52, № 05 (2020): 645–59. http://dx.doi.org/10.1055/s-0039-1690740.

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The Suzuki–Miyaura reaction is one of the most powerful tools for the formation of carbon–carbon bonds in organic synthesis. The utilization of alcohols in this powerful reaction is a challenging task. This short review covers progress in the transition-metal-catalyzed Suzuki­–Miyaura-type cross-coupling reaction of π-activated alcohol, such as aryl, benzylic, allylic, propargylic and allenic alcohols, between 2000 and June 2019.1 Introduction2 Suzuki–Miyaura Cross-Coupling Reactions of Aryl Alcohols2.1 One-Pot Reactions with Pre-activation of the C–O Bond2.1.1 Palladium Catalysis2.1.2 Nickel
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Kazemnejadi, Milad, Rebin Omer Ahmed, and Boshra Mahmoudi. "Ni/Pd-catalyzed Suzuki–Miyaura cross-coupling of alcohols and aldehydes and C–N cross-coupling of nitro and amines via domino redox reactions: base-free, hydride acceptor-free." RSC Advances 10, no. 72 (2020): 43962–74. http://dx.doi.org/10.1039/d0ra08344e.

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A new Ni/Pd bimetallic multifunctional catalytic system has been developed for the domino Suzuki–Miyaura cross-coupling of benzyl alcohols with phenyl boronic acid and domino reduction C–N cross-coupling of the nitro compounds with aryl halides.
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Asgari, M., R. Mirzazadeh, B. Larijani, P. Rashidi Ranjbar, R. Rahimi, and M. Mahdavi. "Palladium-Catalyzed Regioselective Heck–Suzuki–Miyaura Cascade Cyclization for the Synthesis of Trisubstituted Arylideneisoquinolinones." Synlett 30, no. 09 (2019): 1073–76. http://dx.doi.org/10.1055/s-0037-1611804.

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An Ugi four-component reaction was used to construct propargylamide starting materials for a subsequent domino Heck–Suzuki–Miyaura cross-coupling reaction to give derivatives of 4-benzylidene-1-oxo-3,4-dihydro-1H-isoquinoline.
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Gruß, Hendrik, Rebecca C. Feiner, Ridhiwan Mseya, et al. "Peptide stapling by late-stage Suzuki–Miyaura cross-coupling." Beilstein Journal of Organic Chemistry 18 (January 3, 2022): 1–12. http://dx.doi.org/10.3762/bjoc.18.1.

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The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein–protein interactions, which had been considered undruggable for a long time. We disclose a novel approach towards peptide stapling utilising macrocyclisation by late-stage Suzuki–Miyaura cross-coupling of bromotryptophan-containing peptides of the catenin-binding domain of axin. Optimisation of the linker length in order to find a compromise between both sufficient linker rigidity and flexibility resulted in a peptide with an increased α-helici
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Al-Zoubi, Raed, Walid K. Al-Jammal, Mohanad Shkoor, Abdulilah D. Bani-Yaseen, and Michael Ferguson. "Efficient and Direct Route to 5-Iodo-4H-Quinoxalines via Copper-Catalyzed Double C-N Arylations of 1,2,3-Triiodoarenes: Potential Application towards 5-Substituted 4H-Quinoxalines." Synthesis, September 18, 2024. http://dx.doi.org/10.1055/a-2417-9450.

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A simple, direct and regioselective protocol to substituted 5-iodo-4H-quinoxalines through domino double C-N arylations of 1,2,3-triiodobenzene and 1,2-diamines is reported. Remarkably, the N-arylation couplings proceeded unimolecularly at the vicinal positions, the most active and less hindered positions. This domino process tolerated a wide range of aromatic substrates. The reaction of electron-deficient 1,2,3-triiodoarene systems and DMEDA under the optimized conditions provided the highest isolated yields. The chemical transformation of the target compound, which serves as a valuable precu
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Ahmed, Dr Atiur. "Recent Applications of Domino Suzuki-Miyaura Coupling as an Important Tool in the Modern Organic Synthesis." Arkivoc 2024, no. 6 (2025). https://doi.org/10.24820/ark.5550190.p012.353.

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Lei, Xiaoguang, Jin Wang, Jianxiong Zhao, et al. "Concise and Modular Chemoenzymatic Total Synthesis of Bisbenzylisoquinoline Alkaloids." Angewandte Chemie International Edition, September 21, 2024. http://dx.doi.org/10.1002/anie.202414340.

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The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the synthetic community due to their diverse and intriguing biological activities. Herein, we report the convergent and modular chemoenzymatic syntheses of eight bisBIAs bearing various substitutes and linkages in 5‐7 steps. The gram‐scale synthesis of various well‐designed enantiopure benzylisoquinoline monomers was accomplished via an enzymatic stereoselective Pictet–Spengler reaction, followed by regioselective enzymatic methylation or chemical functionalizations in a sequential one‐pot process. A modifie
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Lei, Xiaoguang, Jin Wang, Jianxiong Zhao, et al. "Concise and Modular Chemoenzymatic Total Synthesis of Bisbenzylisoquinoline Alkaloids." Angewandte Chemie, September 21, 2024. http://dx.doi.org/10.1002/ange.202414340.

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The bisbenzylisoquinoline alkaloids (bisBIAs) have attracted tremendous attention from the synthetic community due to their diverse and intriguing biological activities. Herein, we report the convergent and modular chemoenzymatic syntheses of eight bisBIAs bearing various substitutes and linkages in 5‐7 steps. The gram‐scale synthesis of various well‐designed enantiopure benzylisoquinoline monomers was accomplished via an enzymatic stereoselective Pictet–Spengler reaction, followed by regioselective enzymatic methylation or chemical functionalizations in a sequential one‐pot process. A modifie
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Wang, Yue, Yicen Ge, Yu Long, et al. "Core‐Cross‐Linked Micellar Nanoreactors for Biaryl Synthesis in Water: Influence of Topological Structures on Catalytic Activity." Macromolecular Rapid Communications, May 22, 2025. https://doi.org/10.1002/marc.202500160.

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AbstractMultiple block copolymers bearing PDMAEMA (poly(2‐(dimethylamino)ethyl methacrylate), PLMA (poly(lauryl methacrylate), and PAMA (poly(allyl methacrylate) segments are synthesized via RAFT (reversible addition‐fragmentation chain transfer) polymerization. Manipulating the cross‐linkage of PAMA in the specific domain of polymeric assemblies affords micellar nanoreactors with different topological structures. After embedded with Pd NPs (nanoparticles) in the corona layer, the core‐cross‐linked micelles demonstrate profound catalytic activity and structural stability in the aqueous Suzuki–
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Dissertations / Theses on the topic "Suzuki-Miyaura domino coupling"

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Bochicchio, Antonella. "Towards the atropo-stereoselective total synthesis of myricanol." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF004/document.

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Le myricanol est un [7,0]-métacyclophane naturel qui appartient à la famille des diarylheptanoïdes cycliques et qui possède des propriétés structurales et biologiques intéressantes (activité anti-Alzheimer ou anticancéreuse). L’objectif de ce travail de thèse est la préparation ambitieuse en voie racémique puis atropostéréosélective du myricanol, rendue délicate de part la tension de cycle existante. Pour se faire, deux nouvelles approches rétrosynthétiques ont été considérées. Une première route racémique a été envisagée et a permis de préparer le macrocycle par le biais d’une réaction de mét
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Santarsiere, Alessandro. "A new total synthesis of myricanol : the influence of an ene-yne system." Electronic Thesis or Diss., Strasbourg, 2024. https://publication-theses.unistra.fr/public/theses_doctorat/2024/Santarsiere_Alessandro_2024_ED222.pdf.

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L'objectif principal de cette thèse de doctorat est la synthèse totale du myricanol, un composé naturel important aux activités biologiques intéressantes. En particulier, ses remarquables propriétés anti-Alzheimer en font un candidat potentiel pour le traitement de diverses taupathies, car il est capable de réduire les niveaux de protéine Tau qui ont tendance à s'accumuler sous forme phosphorylée dans certaines maladies neurodégénératives.. Actuellement, seules trois synthèses racémiques du (+/-)-myricanol sont rapportées dans la littérature. Tout d'abord, cette thèse vise principalement à exp
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Heidemann, Sven. "Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://hdl.handle.net/11858/00-1735-0000-002B-7C16-4.

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