Academic literature on the topic 'Sven Regener'

Background:Behçet’s syndrome, a chronic, multi-system variable vessel vasculitis, is often characterized by painful oral ulcers (OU) affecting quality of life (QoL). Apremilast (APR), an oral PDE4 inhibitor, demonstrated efficacy in OU treatment in the phase 3 multinational RELIEF study.Objectives:To evaluate APR efficacy in OU treatment in patients with active Behçet’s syndrome in a prespecified subgroup of patients enrolled in 13 European RELIEF sites (France, Germany, Greece, and Italy).Methods:patients were adults with active Behçet’s syndrome and ≥3 OU at randomization or ≥2 OU at screening and randomization, without active major organ involvement. Patients were randomized (1:1) to APR 30 mg BID or PBO during a 12-week double-blind phase. The primary endpoint was area under the curve for the number of OU through Week 12 (AUCWk0-12). Other outcomes were OU pain visual analog scale (VAS); achievement of OU complete response (ie, OU-free) and maintenance of OU complete response (ie, complete response at Week 6 and remaining OU-free for ≥6 additional weeks); OU partial response (ie, OU reduction ≥50%); disease activity (Behçet’s Syndrome Activity Score [BSAS]; Behçet’s Disease Current Activity Form [BDCAF], including Behçet’s Disease Current Activity Index [BDCAI], and Patient’s and Clinician’s Perception of Disease Activity); and QoL (BDQoL; Short Form Health Survey version 2 [SF-36v2], including Physical Functioning [PF] scale and Physical and Mental Component Summary [PCS, MCS]).Results:Of 207 patients randomized and treated in RELIEF, 52 were in the European subgroup. Mean (±SD) age in the subgroup was 39 (±12) years; 54% were women. Baseline disease characteristics were similar between treatment groups (Table 1). Patients receiving APR achieved lower AUCWk0-12 for OU vs PBO (Figure 1) and greater reduction in pain. A greater proportion of patients receiving APR achieved complete, maintained, or partial OU responses at Week 12 vs those receiving PBO (Table 1). Consistent treatment effects favoring APR vs PBO were observed in disease activity, as shown by BSAS and BDCAF component scores at Week 12 (Table 1). Greater improvement in SF-36v2 MCS was observed favoring APR vs PBO at Week 12, and moderate treatment differences were seen for other QoL measures (BDQoL, SF-36v2 PF, and SF-36v2 PCS).Conclusion:In the European subgroup of patients with Behçet’s syndrome and OU in RELIEF, APR resulted in greater reduction in OU count, OU pain, and disease activity as well as favorable treatment effect on QoL measures than PBO. These results are consistent with the efficacy of APR treatment in the overall RELIEF population.Baseline Disease Characteristics, Mean*PBO (n = 27)APR (n = 25)Duration of BD, years9.08.2OU count3.84.0OU pain (VAS 0-100)60.664.2BSAS (0-100)38.741.4BDCAI (0-12)3.53.6BDQoL (0-30)10.59.0Efficacy Outcomes at 12 Weeks*PBO (n = 27)APR (n = 25)Treatment Difference [95% CI]OU pain (VAS 0-100), mean†–17.7–48.7–31.0 [–44.7, –17.3]OU complete response, n (%)‡4 (14.8)16 (64.0)51.5 [29.8, 73.3]OU maintained response, n (%)‡1 (3.7)8 (32.0)26.7 [7.4, 46.0]OU partial response, n (%)‡11 (40.7)21 (84.0)46.0 [23.9, 68.0]BSAS (0-100)†,§–5.23–20.68–15.5 [–22.6, –8.3]BDCAI (0-12)†,§–0.0–1.4–1.4 [–2.2, –0.6]Patient’s Perception of Disease Activity†,§–0.4–1.6–1.2 [–2.1, –0.4]Clinician’s Overall Perception of Disease Activity†,§−0.6−1.7–1.0 [–1.7, –0.4]BDQoL (0-30)†,§–1.25–2.37–1.12 [–3.8, 1.5]SF-36v2 MCS (0-100)†,§–2.14.26.3 [2.2, 10.4]*ITT population.†LS mean of the change from baseline at Week 12.‡Non-responder imputation for missing data.§LOCF approach. All efficacy endpoints (except BDQoL) were significant at the level of P<0.05.Acknowledgements :This study was funded by Celgene. Additional analyses were funded by Amgen Inc. Writing support was funded by Amgen Inc. and provided by Kristin Carlin, RPh, MBA, of Peloton Advantage, LLC, an OPEN Health company.Disclosure of Interests:Alfred Mahr Speakers bureau: Chugai; Roche, Consultant of: Celgene; Chugai, Gulen Hatemi Speakers bureau: AbbVie, Novartis, and UCB, Grant/research support from: Celgene, Mitsuhiro Takeno Speakers bureau: AbbVie, Esai, and Mitsubishi-Tanabe, Consultant of: Celgene, Grant/research support from: Novartis, Doyoung Kim: None declared, Melike Melikoglu: None declared, david Saadoun Consultant of: AbbVie, Celgene, Janssen, and Roche, Grant/research support from: AbbVie and Roche, Christos C. Zouboulis Speakers bureau: Amgen, Galderma, Pierre Fabre, PPM and Sobi, Consultant of: AbbVie, AccureAcne, Almirall, Bayer Healthcare, GSK/Stiefel, Incyte, Inflarx, Janssen, Novartis, PPM, Regeneron, and UCB, Grant/research support from: Celgene, NAOS-BIODERMA, and Relaxera, Sue Cheng Employee of: Amgen Inc, Sven Richter Employee of: Amgen Inc, Shauna Jardon Employee of: Amgen Inc, Maria Paris Employee of: Amgen Inc, Mindy Chen Employee of: Amgen Inc, Yusuf Yazici Consultant of: Bristol-Myers Squibb, Celgene, Genentech, and Sanofi

Der Beitrag liefert eine kultursoziologische Diskussion des Künstler-Intermediäre-Verhältnisses und der Disruptionen, denen dieses Verhältnis im Zuge der Digitalisierung ausgesetzt ist. Vor diesem Hintergrund werden die Aushandlungsdynamiken über den „Wert der Musik“ anhand von Leserkommentaren zur sog. „Wutrede“ des Autors und Element of CrimeFrontmanns Sven Regener im Bayerischen Rundfunk aus dem Jahr 2012 exemplarisch analysiert und feldtheoretisch eingeordnet. Dabei zeigt sich, dass die Frage nach dem „Wert der Musik“ hier nicht bloß im ökonomischen, sondern im umfassenden Sinne adressiert wird. Die aktuelle „Krise der Musik“ kann in diesem Zusammenhang aus den Brüchen im Verhältnis von Musikschaffenden und Markt erklärt werden, die sich innerhalb eines Feldes vollziehen, das gegenwärtig „zentrifugalen Strukturdynamiken“ unterliegt.

Jusqu'à présent, il est supposé que le roman d'adolescent (Adoleszensroman) est un genre qui traite de la formation de l'identité des jeunes au cours de leur adolescence. La présente thèse propose de définir plus précisément le roman d'adolescent en fonction de deux nouvelles caractéristiques: celle du «sort de l'initiative» (Schicksal der Initiative) et celle du «jugement historique» (historisches Urteil). A ces caractéristiques du roman d'adolescent se juxtapose en outre le thème de la formation identitaire. L'étude se concentre sur les romans publiés dans le monde germanophone depuis les années 90. La thèse adopte une approche historique (literarhistorisch) et herméneutique. La théorie sociologique du genre littéraire contribue à expliquer le tournant et la conjoncture historique des catégories littéraires. L'étude tente d'expliquer que le récit du «travail sur l'identité» par un jeune adolescent est un thème auquel un deuxième s'oppose, à savoir que l'adolescent devient conscient de son «initiation» dans le cadre de sa recherche identitaire et confronte ses plus ou moins «naïves» attentes avec la réalité historique d'une société. Le corpus de romans étudié forme le genre du roman d'adolescent (Adoleszensroman) qui se laisse définir comme le «roman d'adolescent du réalisme post-moderne». Il s'inscrit dans un contexte littéraire et historique dominant à partir de 1995 l'espace germanophone, mais aussi anglophone, et relève d'une certaine «sobriété» (Nüchternheit) morale et politique
Until now, it is assumed that the novel of adolescence (Adoleszensroman) is a genre that deals with the formation of identity during adolescence. This thesis proposes a more precise definition for the novel of adolescence based on two new features: the "fate of the initiative" (Schicksal der Initiative) and the "historical judgment" (historisches Urteil). These two characteristics of the novel of adolescence are complemented by the already known characteristic of the narration of formation of adolescent identity. The study focuses on novels published in Germany and Austria since the 90s. The thesis adopts a hermeneutic and historical approach (hermeneutisch und literarhistorisch). Sociological theory of literary forms helps to explain the change and the historical conditions of literary genres. The study attempts to explain that the narration of the adolescent "formation of identity" in the novel of adolescence is a theme which complements a second theme: the adolescent takes the "initiative" within the context of his search for identity and confronts his more or less "naive" expectationswith the historical reality of a society. The corpus of novels studied within the thesis form a genre of novels of adolescence (Adoleszensroman-Genre) which can be defined as "novels of adolescence of postmodern realism". It is part of the dominant literary and historical atmosphere which began ca. 1995 and can be characterized by a certain moral and political "sobriety" (Nüchternheit)

The diploma thesis deals with the depiction of West Berlin in the 1980s in a novel by Sven Regener Herr Lehmann written in 2001, which was published in Czech under the title Ještě jedno, pane Lehmanne. The aim of the thesis is to capture the everyday life and atmosphere of the Kreuzberg district of Berlin just before the fall of the Berlin Wall. Kreuzberg district has been still the center of an alternative cultural scene. In the shadow of the Berlin Wall, this district is famous for its boisterous nightlife, dense network of nightclubs and openness to the world. The thesis follows in the footsteps of the main character Frank Lehmann, called Mr. Lehmann by his friends, because in the novel, he will soon celebrate his thirtieth birthday. In the theoretical part, the thesis firstly deals with "literary space" as an important phenomenon of literary science. This theoretical part is followed by the presentation of the novel itself and its placement in the historical-literary context. The analysis of the novel itself gradually presents the time and scene of the story, the atmosphere of Kreuzberg in the 1980s, the characteristics of the characters and finally the displaying of political events. In its conclusion, the thesis also propose a comparison of the novel with the film adaptation of 2003.