Relevant bibliographies by topics / Switch activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Switch activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Switch activity"

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Cau, Elise, and Patrick Blader. "Notch activity in the nervous system: to switch or not switch?" Neural Development 4, no. 1 (2009): 36. http://dx.doi.org/10.1186/1749-8104-4-36.

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Jakob, Ursula, Wilson Muse, Markus Eser, and James C. A. Bardwell. "Chaperone Activity with a Redox Switch." Cell 96, no. 3 (February 1999): 341–52. http://dx.doi.org/10.1016/s0092-8674(00)80547-4.

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Rees, Holly A., and Nicole M. Gaudelli. "A Dimmer-Switch for SpCas9 Activity." CRISPR Journal 2, no. 3 (June 2019): 146–48. http://dx.doi.org/10.1089/crispr.2019.29060.hre.

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Dal Co, Alma, Martin Ackermann, and Simon van Vliet. "Metabolic activity affects the response of single cells to a nutrient switch in structured populations." Journal of The Royal Society Interface 16, no. 156 (July 2019): 20190182. http://dx.doi.org/10.1098/rsif.2019.0182.

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Microbes live in ever-changing environments where they need to adapt their metabolism to different nutrient conditions. Many studies have characterized the response of genetically identical cells to nutrient switches in homogeneous cultures; however, in nature, microbes often live in spatially structured groups such as biofilms where cells can create metabolic gradients by consuming and releasing nutrients. Consequently, cells experience different local microenvironments and vary in their phenotype. How does this phenotypic variation affect the ability of cells to cope with nutrient switches? Here, we address this question by growing dense populations of Escherichia coli in microfluidic chambers and studying a switch from glucose to acetate at the single-cell level. Before the switch, cells vary in their metabolic activity: some grow on glucose, while others cross-feed on acetate. After the switch, only few cells can resume growth after a period of lag. The probability to resume growth depends on a cells' phenotype prior to the switch: it is highest for cells cross-feeding on acetate, while it depends in a non-monotonic way on the growth rate for cells growing on glucose. Our results suggest that the strong phenotypic variation in spatially structured populations might enhance their ability to cope with fluctuating environments.
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Carver, Brian T., Carl W. Hollingsworth, and Jonathan D. Stanley. "Recent Auditor Downgrade Activity and Changes in Clients' Discretionary Accruals." AUDITING: A Journal of Practice & Theory 30, no. 3 (August 1, 2011): 33–58. http://dx.doi.org/10.2308/ajpt-10053.

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SUMMARY This study examines whether recent auditor downgrade activity is associated with subsequent changes in clients' discretionary accruals. The market for audit services has undergone dramatic change in recent years, resulting in a substantial increase in the number of clients realigning to smaller auditors. This shift in the audit market raises concern about the potential adverse effects of clients moving away from larger, and perhaps more effective, auditors. Consistent with this concern, our analysis of auditor switches occurring between 2003 and 2005 indicates that downgrade clients reported a significant increase in signed discretionary accruals over the two years following the switch. In contrast, we find no significant change in discretionary accruals for a control sample of lateral switches. However, between-sample comparisons fail to provide consistent evidence that the two groups reported accrual changes differently following the auditor switch. Data Availability: Data are available from the public sources identified in the text.
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Mujiono, Muji Adi, and Thalia Medina Diputri. "INTRA-SENTENTIAL SWITCHING USE IN CLASSROOM ACTIVITY." PROJECT (Professional Journal of English Education) 1, no. 5 (September 1, 2018): 568. http://dx.doi.org/10.22460/project.v1i5.p568-572.

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The research focused in the intra-sentential code switching used by the students in English Department of IKIP Siliwangi Bandung. The research was conducted to find out the intra-sentential switching that used by the students, why the students switch code, and the function of intra-sentential switching in classroom activity. The research employed a qualitative descriptive study involing field research. The samples are 3 groups presentation from class A2 English Education 2015 IKIP Siliwangi Bandung. This study explored pattern of intra-sentential code-switching (CS) that are manifest in classroom activity of English-Indonesia-Sunda in class A2 English Education 2015 IKIP Siliwangi Bandung, the reason why students switch thier code and in what situation students switch their code or language. The result of this research are 3 groups presentation were switching their language in type of intra-sentential switching, the reasons they switch their langugae are less vocabulary, to make they easier to express their mind, to make listener or audience easier to understand, and nervous. In presentation, group discussion, speech & daily conversation are situations they switch their code or language.Keywords: Code switching, Intra-sentential switching, classroom activity.
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Liu, Lijun, Susy C. Kohout, Qiang Xu, Simone Mueller, Ehud Y. Isacoff, and Dan Minor. "Internal Switch Gates Phosphatase Activity of VSP." Biophysical Journal 102, no. 3 (January 2012): 36a—37a. http://dx.doi.org/10.1016/j.bpj.2011.11.226.

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Collins, Scott P., William Rostain, Chunyu Liao, and Chase L. Beisel. "Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR–Cas12a gRNA switch." Nucleic Acids Research 49, no. 5 (February 22, 2021): 2985–99. http://dx.doi.org/10.1093/nar/gkab100.

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Abstract CRISPR technologies increasingly require spatiotemporal and dosage control of nuclease activity. One promising strategy involves linking nuclease activity to a cell's transcriptional state by engineering guide RNAs (gRNAs) to function only after complexing with a ‘trigger’ RNA. However, standard gRNA switch designs do not allow independent selection of trigger and guide sequences, limiting gRNA switch application. Here, we demonstrate the modular design of Cas12a gRNA switches that decouples selection of these sequences. The 5′ end of the Cas12a gRNA is fused to two distinct and non-overlapping domains: one base pairs with the gRNA repeat, blocking formation of a hairpin required for Cas12a recognition; the other hybridizes to the RNA trigger, stimulating refolding of the gRNA repeat and subsequent gRNA-dependent Cas12a activity. Using a cell-free transcription-translation system and Escherichia coli, we show that designed gRNA switches can respond to different triggers and target different DNA sequences. Modulating the length and composition of the sensory domain altered gRNA switch performance. Finally, gRNA switches could be designed to sense endogenous RNAs expressed only under specific growth conditions, rendering Cas12a targeting activity dependent on cellular metabolism and stress. Our design framework thus further enables tethering of CRISPR activities to cellular states.
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Kiltz, U., S. Tsiami, X. Baraliakos, and J. Braun. "AB1171 Effects of successive switches of two different biosimilars of etanercept on outcomes in inflammatory rheumatic diseases in daily practice." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1876.1–1876. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3640.

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Background:A single switch from an originator to a biosimilar product has been shown to be safe and effective in the treatment of rheumatic musculoskeletal diseases (RMDs). The availability of biosimilars has created a financial incentive to encourage switching to cheaper products (“non-medical switch”). This is naturally associated with multiple switches. However, the effect of multiple switching between biosimilars of the same reference product has not been thoroughly investigated to date.Objectives:To assess the effectiveness and safety of systematic non-medical switching from innovator etanercept (ETN) to biosimilar ETN (SB4) and successive to another biosimilar ETN (GP2015) in adult patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA) in a real-life setting.Methods:This retrospective study was performed in a tertiary center in adult patients with RA, PsA or axSpA who had been treated with the innovator ETN and who had been switched to two ETN biosimilars for economic reasons thereafter. The first switch from innovator ETN to the first biosimilar ETN occurred between February-May 2017 and the second switch from the first to the second biosimilar ETN occurred between September-December 2017. The end of the observation period was October 2019. Disease activity, function and adverse events (AE) were regularly assessed, and any changes in outcome were recorded during the follow-up period. The scores documented at week 12 week after the second switch were taken as primary outcome.A total of 100 patients (54 RA, 27 axSpA, 19 PsA, mean age 54.3±15.1, 46% male) who switched twice to those ETN biosimilars over a follow-up period of 21.1±7.4 months were included. The retention rate after the second ETN biosimilar switch was 89% about 6 months after the second switch. While 2 patients were lost to follow-up and 1 patient died (cardiac arrest), 7 patients discontinued due to inefficacy or AE, including one pancreatic cancer. One patient was withdrawn due to pregnancy. Overall, 14 AEs were reported in 8 patients. Among them, 4 patients switched back to originator etanercept in month 6, 1 patient re-administered GP2015 successfully in month 3 after suffering from mucosal erosions and in 3 patients another mode of action was prescribed. The scores at week 12 of both, disease activity and function, remained unchanged (Table 1).Table 1.Patient characteristicsAssessmentBaseline(n=100)SB4 Follow-up 12 weeks(n=100)SB 4 Follow-up 24 weeks(n=100)Second switch to GP2015(n=100)GP2015 Follow-up 12 weeks(n=97)GP2015 Follow-up 24 weeks(n=89)RADAS283,0 (1,2)2,9 (1,4)3,1 (1,2)2,8 (1,4)3,4 (2,5)3,0 (1,4)HAQ1,4 (0,8)1,6 (0,9)1,0 (0,9)1,5 (0,8)1,5 (0,8)1,6 (0,9)PsADAS283,8 (1,4)1,9 (1,4)2,8 (1,5)3,1 (1,1)4,5 (2,6)3,6 (2,6)HAQ1,2 (0,9)1,0 (0,9)0,9 (0,9)1,0 (0,8)1,0 (0,9)1,2 (0,8)axSpABASDAI5,1 (2,7)4,5 (2,6)5,1 (3,8)4,1 (2,2)4,6 (2,5)4,3 (2,4)ASDAS3,4 (0,8)2,5 (0,8)2,7 (0,8)3,2 (1,8)2,7 (1,2)2,5 (0,9)BASFI4,4 (2,7)4,3 (2,7)4,3 (3,2)4,6 (2,6)4,5 (2,7)4,8 (3,0)*Values are mean ± standard deviationDisclosure: Hexal funded this researchConclusion:The retention rate after multiple switches from innovator ETN to two ETN biosimilars was close to 90%. No major changes in disease activity and function were observed in all three indications.
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Chan, Jason L., Michael J. Koval, Kevin Johnston, and Stefan Everling. "Neural correlates for task switching in the macaque superior colliculus." Journal of Neurophysiology 118, no. 4 (October 1, 2017): 2156–70. http://dx.doi.org/10.1152/jn.00139.2017.

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Successful task switching requires a network of brain areas to select, maintain, implement, and execute the appropriate task. Although frontoparietal brain areas are thought to play a critical role in task switching by selecting and encoding task rules and exerting top-down control, how brain areas closer to the execution of tasks participate in task switching is unclear. The superior colliculus (SC) integrates information from various brain areas to generate saccades and is likely influenced by task switching. Here, we investigated switch costs in nonhuman primates and their neural correlates in the activity of SC saccade-related neurons in monkeys performing cued, randomly interleaved pro- and anti-saccade trials. We predicted that behavioral switch costs would be associated with differential modulations of SC activity in trials on which the task was switched vs. repeated, with activity on the current trial resembling that associated with the task set of the previous trial when a switch occurred. We observed both error rate and reaction time switch costs and changes in the discharge rate and timing of activity in SC neurons between switch and repeat trials. These changes were present later in the task only after fixation on the cue stimuli but before saccade onset. These results further establish switch costs in macaque monkeys and suggest that SC activity is modulated by task-switching processes in a manner inconsistent with the concept of task set inertia. NEW & NOTEWORTHY Task-switching behavior and superior colliculus (SC) activity were investigated in nonhuman primates performing randomly interleaved pro- and anti-saccade tasks. Here, we report error rate and reaction time switch costs in macaque monkeys and associated differences in stimulus-related activity of saccade-related neurons in the SC. These results provide a neural correlate for task switching and suggest that the SC is modulated by task-switching processes and may reflect the completion of task set reconfiguration.
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Dissertations / Theses on the topic "Switch activity"

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Dan, Östergren. "Automatisk kontroll av status för switch-portar." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-51731.

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I stora nätverksmiljöer kan det idag vara svårt att få en komplett sammanställning av hur många switch-portar som är i bruk. Den lösning som vanligtvis används är manuell inloggning till aktuell switch för kontroll, ett moment med tidsåtgång och som ofta utförs vid enstaka tillfällen. Information riskerar därför att upptäckas för sent med en åtgärd som blir reaktiv. Metoder för att tillgängliggöra informationen på ett sådant sätt att den till stor del kan bli proaktiv kan istället möjliggöra åtgärder i tid men även tillhandahålla aktuell information mer lättillgängligt och i slutändan spara både tid och utgifter för ett företag. Arbetet inriktar sig på framtagandet av en lösning med specifika krav med en inriktning för att förenkla nuvarande moment; att på ett enkelt sätt kunna ta del av dagsaktuell information om status för switch-portar, att kunna få en övergripande bild av fördelningen av switch-portar för en anläggning och möjlighet för notifiering vid gränsöverskridelser. Inledande görs en undersökning av aktuella lösningar som finns att tillgå inom området idag, där flera visar sig ha brister men även saknar nödvändiga funktioner. Då de lösningar som finns tillgängliga idag inte stämmer överens med kraven finns en motivering till framtagandet av en lösning med egna funktioner. Den lösning som tas fram utvecklas med separata funktioner för att inhämta information, tolka, presentera och notifiera information för administratör. För att garantera en stabil lösning med kontinuerlig drift installerades en server i en extern datahall där en linuxdistribution användes. Två olika protokoll för inhämtning av information jämförs med praktiska tester, inloggning via SSH, samt SNMP-poll, där den valda lösningen bygger på SSH som metod på grund av säkerhetsaspekter, men där SNMP visar mer kompatibilitet mellan tillverkare och modeller av hårdvara. Vidare beskrivs tillvägagångssätt hos de funktioner som utvecklats för tolkning av inhämtad information samt de svårigheter som uppstått i samband med detta, för undvikandet av feltolkningar. Olika alternativ för presentation av information till administratör jämförs, där den valda lösningen blev åtkomst via webbsida, detta på grund av det grundläggande stöd oberoende av plattform. Något som exempelvis en applikation inte kan ge i samma omfattning. Bland de olika notifieringsmetoder som undersöktes föll valet även i detta fall på en plattformsoberoende metod, där notifiering via e-post ansågs både enkel att implementera och med ett brett stöd hos klienter. Varningar vid förangivna kriterier av antal lediga switch-portar kunde därmed tas emot av administratör. Samtliga funktioner fungerade vid utförandet som planerat och lösningen används av kunden. Det finns några förslag på förbättringsåtgärder där SNMP istället med fördel kan användas med bredare stöd hos andra tillverkare och modeller, samt även skyddsfunktioner vid tolkning av information.
In large network environments today, it can be difficult to get a complete summary of how many switchports are in use. The solution that is usually used is manual login to the current switch for control, a step with time consumption and which is often performed on occasion. Information therefore risks being discovered too late with a measure that becomes reactive. Methods for making the information available in such a way that it can largely become proactive can instead enable timely action but also provide up-to-date information more easily accessible and ultimately save both time and expenses for a company. The work focuses on the development of a solution with specific requirements with a focus on simplifying current steps; to be able to easily access up-to-date information on the status of switchports, to be able to get an overall picture of the distribution of switchports for a facility and the possibility of notification in the event of border crossings. Initially, an investigation is made of current solutions that are available in the area today, where several turn out to have shortcomings but also lack the necessary functions. As the solutions available today do not comply with the requirements, there is a motivation for developing a solution with its own functions. The solution that is put together is developed with separate functions for collecting information, interpreting, presenting and notifying information to the administrator. To ensure a stable solution with continuous operation, a server was installed in an external datacenter where a Linux distribution was used. Two different protocols for obtaining information are compared with practical tests, login via SSH, and SNMP-poll, where the chosen solution is based on SSH as a method due to security reasons, but where SNMP shows more compatibility between manufacturers and models of hardware. Furthermore, the procedures of the functions that have been developed for the interpretation of collected information and the difficulties that have arisen in connection with this, for the avoidance of misinterpretations are described. Different options for presenting information to the administrator are compared, where the chosen solution was accessed via a website, this is due to the basic support regardless of platform. Something that, for example, an application cannot provide to the same extent. Among the various notification methods examined, the choice also fell in this case on a platform-independent method, where notification via e-mail was considered both easy to implement and with broad support among clients. Warnings for the specified criteria of the number of available switchports could thus be received by the administrator. All functions worked during the execution as planned and the solution is used by the customer. There are some suggestions for improvement measures where SNMP can instead be used to advantage with broader support from other manufacturers and models, as well as protection functions when interpreting information.
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Yamaoki, Yudai. "The development of intelligent ribozyme and RNA aptamer whose activities switch on in response to K⁺via quadruplex formation." Kyoto University, 2016. http://hdl.handle.net/2433/204592.

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Yongyi, Yuan. "Investigation and implementation of data transmission look-ahead D flip-flops." Thesis, Linköping University, Department of Electrical Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2529.

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This thesis investigates four D flip-flops with data transmission look-ahead circuits. Based on logical effort and power-delay products to resize all the transistor widths along the critical path in µm CMOS technology. The main goal is to verify and proof this kind of circuits can be used when the input data have low switching probabilities. From comparing the average energy consumption between the normal D flip-flops and D flip-flops with look-ahead circuits, D flip-flops with look-ahead circuits consume less power when the data switching activities are low.

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Izquierdo, Serra Mercè. "Photoswitchable glutamate receptors to control neurotransmission with light." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/146130.

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Optical tools to control neuronal activity include synthetic photoswitchable ligands of receptors and ion channels. Photoswitches can act either as soluble molecules (photochromic ligands, PCLs) or tethered to the protein (photoswitchable tethered ligands, PTLs), and they have been used to photocontrol many ion channels and receptors such as voltage-gated potassium channels, acetylcholine or glutamate receptors. Recognizing both the need for new optical tools in neuroscience and the opportunities offered by photoswitches, this work is focused on the use of light gated glutamate receptors to control neuronal activity and neurotransmission. In the first chapter of results of the thesis, we demonstrate that the Ca2+-permeable LiGluR can be used as a tool to reversibly control neurosecretion by directly affecting the intracellular [Ca2+]. To achieve this goal, LiGluR was expressed in cultured bovine chromaffin cells and cultured hippocampal neurons. We measured secretion in chromaffin cells using two techniques, amperometry and membrane capacitance, and current-clamp recordings to assess neurotransmission in cultured neurons. The results indicated that the magnitude of LiGluR-mediated Ca2+ influx is sufficiently large to trigger regulated exocytosis in chromaffin cells and neurons. In addition, LiGluR induced secretion can be modulated with the wavelength of illumination. This new application of LiGluR opens the possibility to reversibly control the activity of individual synapses, which might help to understand the computational properties of neurons and to unravel how brain circuits work. To use LiGluR as an effective method to interrogate the neuronal function it should support high-spatial 3D resolution and tissue penetration. Multiphoton excitation with near-infrared light enables stimulation in intact tissue with cellular and subcellular resolution, and it has been extensively applied to optical actuators such as caged compounds and more recently to optogenetics. However, two-photon stimulation of synthetic photoswitches had not been explored before. In the second section of the results, the two-photon stimulation of LiGluR is investigated. Two new photoswitches were designed (MAG2p and MAGA2p) based on the structure of the original photoswitch (MAG) and intended to enhance the two-photon absorption ability of the azobenzene switch. The three PTLs, including MAG, successfully activate LiGluR under two-photon stimulation, suggesting that multiphoton excitation can be applied to other azobenzene-based molecules. Interestingly, the rationally designed photoswitches were more efficient in opening LiGluR as lower power and shorter simulation time were required. Finally we validated MAG2p and MAG as new tools to control the activation of neurons and astrocytes with cellular and subcellular resolution. In the last chapter, a new method based on the affinity labeling approach is presented in order to confer light sensitivity to endogenous receptors. Glutamate-azobenzene-reactive PTLs with different lengths and reactive groups were tested on kainate receptors. These reactive PTLs successfully and functionally conjugate to the ionotropic glutamate receptor subunit GluK1, thus enabling to photoswitch its activity, as evidenced from photocurrent recordings of mammalian cells overexpressing the non-mutated receptor. These results are also supported by the photocontrol of GluK1 currents in dorsal root ganglion neurons, where GluK1 is the main glutamate subunit that is endogenously expressed. The new strategy proposed is versatile and we suggest that it can be extended to label other endogenous receptors, giving rise to novel optpharmacological therapies. The new methods here developed improve the LiGluR performance, and address photoswitches to use endogenous neuronal receptors to optically control neuronal activity, being able to stimulate them in small volumes corresponding to the neuronal functional unit (i.e. synaptic terminals). In this way, light would emerge as a unique tool to dissect neuronal physiology and to understand the function of neuronal circuits.
L’estudi de la neurotransmissió requereix noves eines moleculars, i els fotocommutadors ofereixen grans possibilitats. Aquesta tesi està centrada en l’ús de receptors de glutamat activables per llum (LiGluRs) pel control de l’activitat neuronal i dels processos de neurosecreció. Al primer bloc de resultats, la permeabilitat a Ca2+ dels receptors de glutamat s’aprofita per manipular de manera directa -independentment del voltatge de membrana- i reversible la concentració intracel•lular de Ca2+ amb llum. Així, és possible desencadenar els processos de secreció en cèl•lules cromafins i de neurotransmissió en neurones hipocampals. A la segona part dels resultats de la tesi, s’investiga l’estimulacio multifotó del receptor de glutamat modificat químicament amb fotocommutadors basats en l’azobenzè. Els resultats mostren l’estimulació per dos fotons del LiGluR, incloent-hi dos fotocommutadors nous, que milloren l’absorció multifotó del commutador azobenzè. Finalment, s’aplica aquesta tècnica per estimular neurones i astròcits amb una resolució a l’escala d’una cèl•lula o de compartiment subcel•lular. Al tercer capítol dels resultats, es descriu un nou mètode per aconseguir el fotocontrol de receptors neuronals endògens, utilitzant lligands covalents. Amb l’aplicació d’aquest mètode es pot fotocommutar l’activitat del receptor de kainat subtipus 1 (GluK1) no mutant, quan se sobreexpressa el receptor en cèl•lules de mamífer. Aquesta estratègia també permet obtenir fotocorrents en cultius de neurones dels ganglis de l’arrel dorsal, on GluK1 és la subunitat de glutamat endògenament més expressada. Els nous mètodes desenvolupats en aquesta tesi milloren la utilització dels LiGluRs, encaminant l’ús dels fotocommutadors cap al control òptic dels receptors endògens, amb la possibilitat d’estimular cèl•lules individuals o estructures subneuronals, fet que situaria els fotocomutados com a eines indispensables per l’estudi del cervell, des de la fisiologia fins als circuits neuronals.
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Sherwood, David Alan. "A Simple Metabolic Switch May Activate Apomixis in Arabidopsis thaliana." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7409.

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Apomixis, asexual or clonal seed production in plants, can decrease the cost of producing hybrid seed and enable currently open pollinated crops to be converted to more vigorous and higher yielding hybrids that can reproduce themselves through their own seed. Sexual reproduction may be triggered by a programmed stress signaling event that occurs in both the meiocyte, just prior to meiosis, and later in the egg just prior to embryo sac maturation. The prevention of stress signaling and the activation of a pro-growth signal prior to meiosis triggered apomeiosis, the first half of apomixis. The same approach was used prior to embryo sac maturation to trigger parthenogenesis, the second half of apomixis. This discovery suggests that apomixis exists as a program that can be activated by the appropriate metabolic signal at the appropriate developmental stages. Therefore, apomixis may be alternative mode of reproduction rather a ‘broken’ form of sexual reproduction.
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Olguin-Contreras, Luis Fernando. "Mechanism-guided selection inspired by catalytic promiscuity : activity switches between sulfatase and phosphatase activities." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614083.

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Peswani, Mohnish. "Shape Memory Polymer Composites For Actively-Switched Thermal Management Materials." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1547036586945901.

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Babnič, Patrik. "Možnosti využití neuronových sítí v síťových prvcích." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-218999.

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The goal was to get acquainted with the problems of network elements to describe neural networks that can be used to manage such a feature. The theoretical part deals with the neural networks from their inception to the present. It focuses mainly on the network, witch can be used for management control. These are the two network: Hopfield network and Kohonen network. The practical part deals with the network element model and ist implementation. It contains a practical element model using a neural network, witch is controlled by a network element.
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Auber, Romain. "Contribution à la reconnaissance d'activités à partir d'un objet connecté." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC242.

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Ce manuscrit porte sur la reconnaissance d’activités à partir de données accéléromètriques. Le dispositif utilisé pour collecter les données de l’accéléromètre est eTact, dispositif développé par la société Bodycap. Plusieurs solutions sont proposées afin d'optimiser l’autonomie de l’objet connecté. Ces solutions sont mises en oeuvre et comparées sur différentes séries de données. L'originalité d'une de ces solutions consiste à binariser les données de l’accéléromètre avant de les transférer vers une plateforme externe où elles sont analysées. L’utilisation de données binaires entraîne la perte de nombreuses informations, cependant il est montré dans ce manuscrit qu’il est possible d’estimer, entres autres, les paramètres d'un modèle Auto Régressif d’une série temporelle à partir de l'information binaire sur cette série. A ce titre, un algorithme d'identification est proposé et analysé
This manuscript deals with the recognition of activities from accelerometric data. The device used to collect the accelerometer data is eTact, a device developed by Bodycap. Several solutions are proposed to optimize the autonomy of the connected object. These solutions are implemented and compared on different data sets. The originality of one of these solutions is to binarize the data of the accelerometer before transferring them to an external platform where they are analyzed. The use of binary data induces the loss of a lot of information, however it is shown in this manuscript that it is possible to estimate, among other things, the parameters of an Auto Regressive model of a time series from the binary information on this series. In this respect, an identification algorithm is proposed and analyzed
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Khan, Abdul Kareem. "Electrostaticanalisys the Ras active site." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7161.

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La preorganització electrostàtica del centre actiu s'ha postulat com el mecanisme genèric de l'acció dels enzims. Així, alguns residus "estratègics" es disposarien per catalitzar reaccions interaccionant en una forma més forta amb l'estat de transició, baixant d'aquesta manera el valor de l'energia dactivació g cat. S'ha proposat que aquesta preorientació electrostática s'hauria de poder mostrar analitzant l'estabilitat electrostàtica de residus individuals en el centre actiu.
Ras es una proteïna essencial de senyalització i actúa com un interruptor cel.lular. Les característiques estructurals de Ras en el seu estat actiu (ON) són diferents de les que té a l'estat inactiu (OFF). En aquesta tesi es duu a terme una anàlisi exhaustiva de l'estabilitat dels residus del centre actiu deRas en l'estat actiu i inactiu.
The electrostatic preorganization of the active site has been put forward as the general framework of action of enzymes. Thus, enzymes would position "strategic" residues in such a way to be prepared to catalyze reactions by
interacting in a stronger way with the transition state, in this way decreasing the activation energy g cat for the catalytic process. It has been proposed that
such electrostatic preorientation should be shown by analyzing the electrostatic stability of individual residues in the active site.
Ras protein is an essential signaling molecule and functions as a switch in the
cell. The structural features of the Ras protein in its active state (ON state) are different than those in its inactive state (OFF state). In this thesis, an exhaustive analysis of the stability of residues in the active and inactive Ras active site is performed.
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Books on the topic "Switch activity"

1

Cisco router and switch forensics: Investigating and analyzing malicious network activity. Burlington, MA: Syngress, 2009.

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Liu, Dale. Cisco router and switch forensics: Investigating and analyzing malicious network activity. Burlington, MA: Syngress, 2009.

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Kumita, Janet Reiko. Reversible control of peptide structure and activity by an azobenzene photo-switch. 2003, 2003.

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Minds, Lynwood. Mother Earth Day Activity: Image Quiz Words Activity and Coloring Book 40 Fun Planet Earth, Greenhouse, Recycling, Switch, Hand, Earth, Earth, Earth for Preschool. Independently Published, 2020.

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Books, Maurine. Mother Earth Activity Books: Funny for Kids Printable 55 Picture Quizzes Words Activity Coloring Book Earth Day, Solar Panel, Earth Day, Ecohome, Switch, Solar Panel, Shovel, Earth Globe. Independently Published, 2020.

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Daly, Donna, and Christopher Chapple. Anatomy, neurophysiology, and pharmacological control mechanisms of the bladder. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0034.

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The lower urinary tract has two main functions; the collection and low pressure storage of urine and periodical controlled elimination of urine at an appropriate time. In order to achieve continence during bladder filling and storage and produce efficient and effective bladder emptying, there is accurate coordination between opening and closing of the urethral sphincters and contraction of the detrusor smooth muscle. The process of micturition has two phases: the storage/filling phase and the voiding phase. The analogy for the transition between these two phases has been described as an on-off circuit, rather akin to flicking a light switch, between synchronous bladder contraction and urethral outlet relaxation, and vice versa. These phases are regulated by a complex, integration of somatic and autonomic efferent and afferent mechanisms that coordinate the activity of the bladder and urethra. This chapter provides an overview of our current understanding of these complex mechanisms.
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Martínez-François, Juan Ramón, Nika N. Danial, and Gary Yellen. Metabolic Seizure Resistance via BAD and KATP Channels. Edited by Detlev Boison. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0028.

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On a ketogenic diet, ketone bodies provide an alternative fuel, replacing much of the glucose used ordinarily by the brain. This switch is thought to underlie its anticonvulsant effects. Brain fuel utilization can also be modified by a nondietary approach: genetic alteration of the protein BAD, which has known roles in regulating both apoptosis and glucose metabolism. When the metabolic function of BAD is genetically altered in mice, it produces reduced glucose and increased ketone body metabolism in neurons and astrocytes. This effect is related to regulation of BAD by phosphorylation and is independent of its apoptotic function. Mice with BAD modifications that produce decreased glucose metabolism exhibit a marked increase in the activity of neuronal ATP-sensitive potassium (KATP) channels and strong resistance to behavioral and electrographic seizures in vivo. This seizure resistance is lost upon genetic ablation of KATP channels, suggesting that KATP channels mediate BAD’s anticonvulsant effect.
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The Joy Switch: How Your Brain's Secret Circuit Affects Your Relationships-And How You Can Activate It. Northfield Publishing, 2021.

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Chadwick, Andrew. Hybrid Norms in Activism, Parties, and Government. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190696726.003.0010.

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Chapter 9 builds on the ethnographic approach of Chapter 8 but switches the focus to the fields of political activism, election campaigning, and government communications. It draws on fieldwork among party communication staff; communications staff working inside government departments and in the Prime Minister's Office in Number 10 Downing Street; the director of a prominent public relations company; and members of the renowned million-strong progressive political activist network, 38 Degrees. The chapter reveals how integrated divisions of labor between older and newer media practices are emerging in the daily work of actors in these fields, and how the different types of integration are sometimes bolstering and sometimes weakening the power of those whose dominance rests upon older broadcasting and print media practices.
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SwitHeart: The Watercolour Artistry & Animal Activism of Loretta Swit. Ultimate Symbol, 2017.

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Book chapters on the topic "Switch activity"

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Ballantyne, J., L. Ozsvath, K. Bondarchuk, and K. B. Marcu. "Chromosomally Integrated Retroviral Substrates are Sensitive Indicators of an Antibody Class Switch Recombinase-Like Activity." In Current Topics in Microbiology and Immunology, 439–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79275-5_51.

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Yan, Yuling, and Gerard Marriott. "Optical Manipulation of Protein Activity and Protein Interactions Using Caged Proteins and Optical Switch Protein Conjugates." In Neuromethods, 213–31. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-031-7_12.

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Mutter, Manfred, Karl-Heinz Altmann, Uwe Buttkus, Roland Gassmann, Lothar Kürz, and Anna Seelig. "Switch peptides: Medium induced α-helix to β-sheet transitions of bis-amphiphilic secondary structures and their membrane activity." In Peptides, 344–45. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_125.

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Baran, Jolanta, Tamara Cierpiałowska, and Ewa Dyduch. "The Use of the UDL Approach as a Factor in the Success of Inclusive Education Despite the Pandemic Period." In Inclusive Learning and Educational Equity, 119–44. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80658-3_6.

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AbstractThe action research reported in this chapter lasted for one semester. This was a novel time because schools, due to the COVID-19 pandemic, suspended their in-person activities and implemented online learning. This has necessitated the formulation of research purposes and problems appropriate to the dynamically changing educational reality (and beyond). This chapter provides a theoretical background to the risks to education during a pandemic. The assumptions, implementation and results of the research project implemented by the action research method in the selected Polish class are also discussed. The empirical data, mainly qualitative, triangulated by various sources of information, reconciled perspectives that were used to identify specific topics and threads appearing in the gathered inputs, to present it in an orchestrated manner and to interpret it. The analyses carried out lead to the conclusion that the application of the UDL approach promotes the success of inclusive education, despite the difficult experiences of the pandemic period. It has been proven that UDL approach implementation has a positive impact on the course of the teaching-learning process, optimises it to enhance the activity, commitment, self-reliance and responsibility of students and develops their cooperation, which breeds inclusion in education. The extraordinary situation faced by teachers and pupils due to the need to switch to online learning, contrary to temporary concerns, has reinforced the changes brought about by the implementation of the UDL approach in the learning process.
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Lim, Mandy Yu Theng, and Katsutomo Okamura. "Switches in Dicer Activity During Oogenesis and Early Development." In Results and Problems in Cell Differentiation, 325–51. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60855-6_14.

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Flavell, R. B., M. O'Dell, and M. Metzlaff. "Transgene-Promoted Epigenetic Switches of Chalcone Synthase Activity in Petunia Plants." In Novartis Foundation Symposia, 144–67. Chichester, UK: John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470515501.ch9.

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Miller, Aaron E., Tracy M. DeAngelis, Michelle Fabian, and Ilana Katz Sand. "A Man with Multiple Sclerosis and Continuing Disease Activity on Disease-Modifying Therapy." In Neuroimmunology, 189–94. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190693190.003.0036.

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The decision about whether to switch a patient with multiple sclerosis from one disease-modifying therapy (DMT) to another in the context of disease activity is often difficult. Controlled studies to guide the decision are lacking, and clinicians may differ on the criteria. In addition, the decision about which alternative DMT to choose may vary from one individual situation to another. Some guidance is available from data examining the subsequent behavior of patients taking beta interferon based on their level of disease activity at one year of treatment. Once a decision to switch therapy is made, the patient should avoid a prolonged period off therapy. Special consideration is necessary with certain specific switches.
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Anderson, Cindy L., and Kevin M. Anderson. "Practical Examples of Using Switch-Adapted and Battery-Powered Technology to Benefit Persons With Disabilities." In Handmade Teaching Materials for Students With Disabilities, 212–30. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6240-5.ch009.

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Handmade switch-adapted toys and LED lights were created by a first grader student as part of a makerspace activity to aid a person with disabilities. Commercial toys and light strings were adapted for ease of use by interrupting the electrical current by use of a handmade battery interrupter and the addition of remote switches. In addition, an illuminated glove was created using conductive thread, LED lights, and an Arduino LilyTiny controller to enable the person with disabilities to signal turns on a disability scooter using hand signs. Basic information on the creation of these materials and their possible use are presented in this chapter.
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Anderson, Cindy L., and Kevin M. Anderson. "Practical Examples of Using Switch-Adapted and Battery-Powered Technology to Benefit Persons With Disabilities." In Research Anthology on Physical and Intellectual Disabilities in an Inclusive Society, 736–53. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3542-7.ch040.

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Handmade switch-adapted toys and LED lights were created by a first grader student as part of a makerspace activity to aid a person with disabilities. Commercial toys and light strings were adapted for ease of use by interrupting the electrical current by use of a handmade battery interrupter and the addition of remote switches. In addition, an illuminated glove was created using conductive thread, LED lights, and an Arduino LilyTiny controller to enable the person with disabilities to signal turns on a disability scooter using hand signs. Basic information on the creation of these materials and their possible use are presented in this chapter.
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Snell, Cameron, Kevin C. Gatter, Adrian L. Harris, and Francesco Pezzella. "Cancer and metabolism." In Oxford Textbook of Oncology, 119–24. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199656103.003.0013.

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This chapter covers the relationship between cancer and metabolism. It discusses the role of angiogenesis and metabolic reprogramming in influencing tumour growth. The transcription factors that orchestrate the metabolic switch are discussed. The chapter presents an overview of the contribution of tumour suppressors to increased glycolysis. The metabolic changes that support uncontrolled proliferation such as lactate and pH levels, hypoxia, and reactive oxygen species are discussed. The chapter also covers the contribution of metabolic genes with oncogenic or tumour suppressor activity to metabolic transformation, the upregulation of lipid biosynthesis in cancer, and glycogen synthesis in cancer. The chapter concludes with a description of the potential strategies for targeting metabolic transformation.
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Conference papers on the topic "Switch activity"

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Ramini, Abdallah H., and Mohammad I. Younis. "Enhancing the Sensitivity of Electrostatically Actuated Resonant Switch for Earthquake Detection." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-48597.

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Enhancing the sensitivity of an electrostatically actuated resonant switch (EARS) for earthquake detection is investigated. The resonator is proposed to operate close to instability bands of frequency-response curves, where it is forced to pull-in if operated within these bands. By careful tuning, the resonator can be made to enter the instability zone upon the detection of the earthquake signal, thereby pulling-in as a switch. Such a switching action can be functionalized for alarming purposes or can be used to activate a network of sensors for seismic activity recording. By placing such a resonator on a printed circuit board of a natural frequency close to that of the earthquake’s frequency, significant improvement on the detection limit of this switch is achieved. In this work, nonlinear Single-Degree-Of-Freedom (SDOF) and 2-Degree-Of-Freedom (2-DOF) models are used to simulate the performance of the switch concept.
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Ramini, Abdallah, Mohammad I. Younis, and Quang T. Su. "Low-G Electrostatically Actuated Resonant Switch." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70328.

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This work investigates a new concept of an electrostatically actuated resonant switch (EARS) for earthquake detection and low-g seismic applications. The resonator is proposed to operate close to instability bands of frequency-response curves, where it is forced to pull-in if operated within these bands. By careful tuning, the resonator can be made to enter the instability zone upon the detection of the earthquake signal, thereby pulling-in as a switch. Such a switching action can be functionalized for alarming purposes or can be used to activate a network of sensors for seismic activity recording. The EARS is modeled and its dynamic response is simulated using a nonlinear single degree of freedom model. Experimental investigation is conducted demonstrating the EARS capability of being triggered at small levels of acceleration as low as 0.02 g. Experimental data and simulation results are compared showing good agreement.
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Alper, Joshua, Monica Crespo, Kevin Jones, Andrei Tokmakoff, and Kimberly Hamad-Schifferli. "Biomolecular Activity Switch Actuated by Ultrafast Pulsed Laser Irradiation of Gold Nanorods." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193097.

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In the pursuit of improved medical, diagnostic and therapeutic solutions, scientists and engineers are interested in designing nanoscale machinery to perform a variety of tasks [1]. The most promising of these machines are comprised of natural biological systems or artificial systems that exploit nature’s machinery, namely proteins. In either case, scientists must exert control over proteins to harness the potential of nanoscale biomolecular machinery.
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Alper, Joshua, and Kimberly Hamad-Schifferli. "Biomolecular Activity Switch: An Application of Metallic Nanoparticle Plasmon Resonance and Femtosecond Pulsed Lasers." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68104.

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With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery’s active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.
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Sadreddini, Zhaleh, Tugrul Cavdar, and Erkan Guler. "Performance analysis of the dynamic switch system based on user activity in cognitive radio network." In 2016 39th International Conference on Telecommunications and Signal Processing (TSP). IEEE, 2016. http://dx.doi.org/10.1109/tsp.2016.7760846.

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McCarthy, Derrick P., Sarah Guyette, Michael Lofgren, Jyothi Sethuraman, Thamara DeSilva, Ahmar Aziz, Troy Patterson, et al. "Abstract 893: A chimeric PD1-CD28 switch receptor enhances the activity of TRuC-T cells." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-893.

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Acarkan, B., and K. Erkan. "Harmonics Modeling and Harmonic Activity Analysis of Equipments with Switch Mode Power Supply using MATLAB and Simulink." In 2007 IEEE International Electric Machines & Drives Conference. IEEE, 2007. http://dx.doi.org/10.1109/iemdc.2007.382719.

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Bottacini, Eugenio, Elena Orlando, Giacomo Vianello, and Igor Moskalenko. "The extreme environment in the center of Mrk 876 and the switch on of its AGN activity." In The 34th International Cosmic Ray Conference. Trieste, Italy: Sissa Medialab, 2016. http://dx.doi.org/10.22323/1.236.0822.

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Sathanur, Ashoka, Jos Huisken, Jan Stuyt, and Harmke de Groot. "Activity profile driven simultaneous vt assignment and power switch sizing for leakage power minimization in nanometer CMOS designs." In 2010 17th IEEE International Conference on Electronics, Circuits and Systems - (ICECS 2010). IEEE, 2010. http://dx.doi.org/10.1109/icecs.2010.5724563.

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Kim, Won Kyung, Yuna Pyee, Hyen Joo Park, Ji-Young Hong, and Sang Kook Lee. "Abstract 2322: Antitumor activity of spicatoside A, a steroidal saponin, via induction of switch from autophagy to apoptotic cell death." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2322.

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