Journal articles on the topic 'Switch central resources'

The urban area of the server can be a central control node switch and server node, the node switches and a server node can know the porttraffic information in real time. When the connection existed over between 2 of these devices, a connection can be selected according to the real-time traffic, real-time routing function to avoid network congestion and flow of the uneven distribution of resources. Similarly, node server can central control node switch can know the real-time node switch port flow information, therefore, the node switches can obtain the terminal flow control information from the server to the terminal node data transmission flow control.

Regular physical activity in cyclic sports can influence the so-called “angiogenic switch”, which is considered as an imbalance between proangiogenic and anti-angiogenic molecules. Disruption of the synthesis of angiogenic molecules can be caused by local changes in tissues under the influence of excessive physical exertion and its consequences, such as chronic oxidative stress and associated hypoxia, metabolic acidosis, sports injuries, etc. A review of publications on signaling pathways that activate and inhibit angiogenesis in skeletal muscles, myocardium, lung, and nervous tissue under the influence of intense physical activity in cyclic sports. Materials: We searched PubMed, SCOPUS, Web of Science, Google Scholar, Clinical keys, and e-LIBRARY databases for full-text articles published from 2000 to 2020, using keywords and their combinations. Results: An important aspect of adaptation to training loads in cyclic sports is an increase in the number of capillaries in muscle fibers, which improves the metabolism of skeletal muscles and myocardium, as well as nervous and lung tissue. Recent studies have shown that myocardial endothelial cells not only respond to hemodynamic forces and paracrine signals from neighboring cells, but also take an active part in heart remodeling processes, stimulating the growth and contractility of cardiomyocytes or the production of extracellular matrix proteins in myofibroblasts. As myocardial vascularization plays a central role in the transition from adaptive heart hypertrophy to heart failure, further study of the signaling mechanisms involved in the regulation of angiogenesis in the myocardium is important in sports practice. The study of the “angiogenic switch” problem in the cerebrovascular and cardiovascular systems allows us to claim that the formation of new vessels is mediated by a complex interaction of all growth factors. Although the lungs are one of the limiting systems of the body in cyclic sports, their response to high-intensity loads and other environmental stresses is often overlooked. Airway epithelial cells are the predominant source of several growth factors throughout lung organogenesis and appear to be critical for normal alveolarization, rapid alveolar proliferation, and normal vascular development. There are many controversial questions about the role of growth factors in the physiology and pathology of the lungs. The presented review has demonstrated that when doing sports, it is necessary to give a careful consideration to the possible positive and negative effects of growth factors on muscles, myocardium, lung tissue, and brain. Primarily, the “angiogenic switch” is important in aerobic sports (long distance running). Conclusions: Angiogenesis is a physiological process of the formation of new blood capillaries, which play an important role in the functioning of skeletal muscles, myocardium, lung, and nervous tissue in athletes. Violation of the “angiogenic switch” as a balance between proangiogenic and anti-angiogenic molecules can lead to a decrease in the functional resources of the nervous, musculoskeletal, cardiovascular, and respiratory systems in athletes and, as a consequence, to a decrease in sports performance.

In four experiments a large temporal effect is demonstrated for alternating between different response modes of musical output: sing—whistle, sing–play. This effect, demonstrated for college students with some musical training, has theoretical implications for the setting of response mode parameters. Over the series of four studies, it is shown that the time to alternate between musical output modes is not due to peripheral competition for the components of the same motor system, or to central competition produced by concurrently trying to use the same central resources for several things at once. Syntactic disruption explains some of the alternation effect, but the most complete explanation is attributable to an output parameter setting mechanism in which different response modes may be set to ON/OFF. Both evidence and argument suggest that these parameters are set globally, and it takes time to change their values (about 200 msec per switch).

Until the late 1980s, decentralisation experiments in sub-Saharan Africa tended in the majority of states to reinforce central control rather than enhance local autonomy. However, recent moves towards political pluralism have brought a switch in emphasis to more meaningful types of local participation. These have taken the form of political decentralisation, understood in the sense used by Philip Mawhood to denote the devolution of powers to representative local councils, each with its separate legal existence and its own budget, and with the authority to allocate resources and to carry out multiple functions. However, a number of African regimés also intend to transfer power from the centre to officials of the central government in the field. They therefore attach a broader meaning to the concept of decentralisation, using it to cover both political devolution and the deconcentration of administrative authority. The two processes are, in fact, often complementary rather than separate.

Abstract The North Korean government declared a pursuit of the Military-First Policy and the Ideology of Focusing on Science and Technology in the late 1990s. It thus made science and technology central to its goal of the Establishment of Strong and Prosperous State. North Korea came to perceive science and technology as engines for promoting both nuclear armament and economic development. The switch of policy attention to science and technology has facilitated the development of some selected technology-intensive industries. In 2017, North Korea declared that it had completed development of nuclear weapons and intercontinental ballistic missiles (ICBMs). Although North Korea’s development of hi-tech arms including nuclear bombs and ICBMs appears inconsistent with its low level of economic development, it can be understood in light of the North Korean government’s emphasis on science and technology and prioritization of the allocation of resources to defense.

Protein and oil levels measured at maturity are inversely correlated across soybean lines; however, carbon is in limited supply during maturation resulting in tradeoffs for the production of other reserves including oligosaccharides. During the late stages of seed development, the allocation of carbon for storage reserves changes. Lipid and protein levels decline while concentrations of indigestible raffinose family oligosaccharides (RFOs) increase, leading to a decreased crop value. Since the maternal source of carbon is diminished during seed maturation stages of development, carbon supplied to RFO synthesis likely comes from an internal, turned-over source and may contribute to the reduction in protein and lipid content in mature seeds. In this study, fast neutron (FN) mutagenized soybean populations with deletions in central carbon metabolic genes were examined for trends in oil, protein, sugar, and RFO accumulation leading to an altered final composition. Two lines with concurrent increases in oil and protein, by combined 10%, were identified. A delayed switch in carbon allocation towards RFO biosynthesis resulted in extended lipid accumulation and without compromising protein. Strategies for future soybean improvement using FN resources are described.

Based on Law 23 of 2014 on Regional Government, there is a change in the distribution of affairs in the management of education. Secondary education (SMA / SMK) previously administered by regency / municipality government based on the law is the authority of its management to switch to provincial government. This article will discuss how the process of execution of transfer of authority of secondary education from regency / municipality government to Central Java Provincial Government. Using qualitative research, this article will provide a critical analytical understanding of the transition process or the delegation of secondary education authorities in the areas of Asset, Human Resources (HR) and Finance from the Regency / City government to the Provincial Government in Central Java. The research findings show that the delegation of authority at the level of the Provincial Government actually makes the model of government farther away from idealism to provide services closer to the community. Because the implementation of this policy impact on local government policy, which has been eliminating education for 12 years, ie from elementary school to high school. As a result of the transfer of management function to the province, now the free education policy for SMA and SMK had to stop as well as happened in Kudus, Sukoharjo, Karanganyar. The community hopes the Central Java Provincial Government still holds a commitment to free education, both for public and private schools for high school / vocational high school level. In addition, there is hope from the community for the Provincial Government to implement a commitment not to withdraw fees, levies or donations after the transfer of education authority to the Central Java provincial government.

Background: From August 2017 to June 2018, 11 hospitals within a large healthcare system switched from multiple different electronic medical records (EMRs) to 1 EMR. At the time of this transition, the NHSN provided guidelines to validate healthcare-associated infection (HAI) denominators when switching from manual denominator collection to electronic denominator collection, but the NHSN did not give guidelines for validation when switching from 1 EMR to another. We aimed to build a validation process to ensure the accuracy of central-line and urinary catheter days reported to the NHSN after switching EMRs. Methods: Our validation process began with a statistical phase followed by a targeted manual validation phase. The statistical phase used 3 prediction methods (linear regression, time series analysis, and statistical process control [SPC] charts) to forecast device days after the EMR switch for units within hospitals. Models were developed using baseline data from the old EMR (January 2015 through the new EMR implementation). Using prespecified criteria for each method to determine discrepancies, we built a decision tree to identify units needing manual validation. Any unit that failed the statistical phase would need to participate in the manual validation phase, using a midnight census and direct visualization of devices. The manual validation process was composed of 14-day blocks. At the end of each block, if manual device days were within ±5% of EMR device days, they were considered validated. Manual validation would be repeated in 14-day blocks until 2 consecutive blocks passed within ±5%. Results: Overall, 157 units were evaluated for urinary catheter days and central-line days. Among them, 143 units passed the statistical validation test for urinary catheter days and 151 passed for central-line days. There was no specific pattern when comparing forecasted versus actual device days. The manual validation process for the 20 failing units (14 urinary catheter and 6 central-line units) is ongoing; preliminary results identified issues with missing nursing documentation in the EMR and with inaccurate manual counting of device days. There were no systematic discrepancies associated with the new EMR. Conclusions: We developed a novel validation process using statistical prediction methods supplemented with a targeted manual process. This process saved resources by identifying the units that need manual validation. Discrepancies were largely related to nursing documentation, which the infection prevention team addressed with additional training.Funding: NoneDisclosures: None

SUMMARYThe viability of commercial potato production is influenced by spatial and temporal variability in soils and agroclimate, and the availability of water resources where supplementary irrigation is required. Soil characteristics and agroclimatic conditions greatly influence the cultivar choice, agronomic husbandry practices and the economics of production. Using the latest (UKCP09) scenarios of climate change for the UK, the present paper describes a methodology using pedo-climatic functions and a geographical information system (GIS) to model and map current and future land suitability for potato production in England and Wales. The outputs identify regions where rainfed production is likely to become limiting and where future irrigated production would be constrained due to shortages in water availability. The results suggest that by the 2050s, the area of land that is currently well or moderately suited for rainfed production would decline by 88 and 74%, respectively, under the ‘most likely’ climate projections for the low emissions scenario and by 95 and 86%, respectively, for the high emissions scenario, owing to increased likelihood of dry conditions. In many areas, rainfed production would become increasingly risky. However, with supplementary irrigation, c. 0·85 of the total arable land in central and eastern England would remain suitable for production, although most of this is in catchments where water resources are already over-licensed and/or over-abstracted; the expansion of irrigated cropping is thus likely to be constrained by water availability. The increase in the volume of water required due to the switch from rainfed- to irrigated-potato cropping is likely to be much greater than the incremental increase in water demand solely on irrigated potatoes. The implications of climate change on the potato industry, the adaptation options and responses available, and the uncertainty associated with the land suitability projections, are discussed.

Ethnic communities in Indonesia mostly live in rural areas by making use of natural resources and agriculture as the main livelihood. The typical ordinance determines the gender division of labour carried out ethnic communities on the farming system. One of the ethnic communities in Central Java who live in rural areas and make use of natural resources for agricultural activity is community Samin. The purpose of this research, in general, is to analyzing the pattern of the division of gender roles in the household economy of the farmers in the indigenous communities. The research uses quantitative methods supported by qualitative methods. The research shows the principle of the sareng-sareng (together) is used on the farmer households in sedulur sikep. Division of labor in farmers houseolds of communities sedulur sikep is more flexible compared to the division of labor in farmers household of non sedulur sikep because work is done mostly in agriculture that makes it easy to switch roles in the division of laborKeywords: Ethnic communities, farming households, gender ABSTRAK Komunitas etnis di Indonesia sebagian besar hidup di daerah pedesaan dengan memanfaatkan sumberdaya alam dan menjadikan pertanian sebagai mata pencaharian utama. Tata cara yang khas menentukan pembagian kerja gender yang dilakukan komunitas etnis pada sistem pertanian. Salah satu komunitas etnis di Jawa Tengah yang hidup di pedesaan serta memanfaatkan sumberdaya alam untuk aktivitas pertanian adalah komunitas Samin. Tujuan penelitian ini secara umum yaitu menganalisis pola pembagian peran gender dalam perekonomian rumah tangga petani di masyarakat adat. Penelitian dilakukan dengan metode kuantitatif didukung dengan metode kualitatif. Hasil penelitian menunjukkan bahwa prinsip sareng-sareng (bersama-sama) digunakan pada rumah tangga petani di sedulur sikep. Pekerjaan yang dilakukan sedulur sikep sebagian besar di bidang pertanian memudahkan untuk penggantian peran dalam pembagian kerja sehingga pembagian kerja rumah tangga petani di komunitas sedulur sikep lebih fleksibel dibandingkan dengan pembagian kerja rumah tangga petani di non sedulur sikep.Kata Kunci : Gender, komunitas etnis, rumah tangga petani

Consumers usually respond to variations in prey availability by altering their foraging strategies. Generalist consumers forage on a diversity of resources and have greater potential to ‘switch’ their diet in response to fluctuations in prey availability, in comparison to specialist consumers. We aimed to determine how the diets of two specialist species (the eastern long-necked turtle (Chelodina longicollis) and the broad-shelled turtle (Chelodina expansa) and the more generalist Murray River short-necked turtle (Emydura macquarii) respond to variation in habitat and prey availability. We trapped and stomach-flushed turtles, and compared their diets along with environmental variables (turbidity, macrophyte and filamentous green algae cover, and aquatic invertebrate diversity and abundance) at four wetlands in north-central Victoria. Diets of E. macquarii differed from those of both Chelodina species, which overlapped, across all four sites. However, samples sizes for the two Chelodina species were too small to compare among-wetland variation in diet. Dietary composition of E. macquarii was variable but did not differ statistically among sites. Emydura macquarii preferentially selected filamentous green algae at three of the four sites. Where filamentous green algae were rare, total food bolus volume was reduced and E. macquarii only partially replaced it with other food items, including other vegetation, wood, and animal prey. Many turtles at these sites also had empty stomachs. Thus, filamentous green algae may be a limiting food for E. macquarii. Although E. macquarii has previously been described as a generalist, it appears to have limited ability to replace filamentous green algae with other food items when filamentous green algae are rare.

Cell division and tissue growth must be coordinated with development. Defects in these processes are the basis for a number of diseases, including developmental malformations and cancer. We have conducted an unbiased RNAi screen for genes that are required for growth in the Drosophila wing, using GAL4-inducible short hairpin RNA (shRNA) fly strains made by the Drosophila RNAi Screening Center. shRNA expression down the center of the larval wing disc using dpp-GAL4, and the central region of the adult wing was then scored for tissue growth and wing hair morphology. Out of 4,753 shRNA crosses that survived to adulthood, 18 had impaired wing growth. FlyBase and the new Alliance of Genome Resources knowledgebases were used to determine the known or predicted functions of these genes and the association of their human orthologs with disease. The function of eight of the genes identified has not been previously defined in Drosophila. The genes identified included those with known or predicted functions in cell cycle, chromosome segregation, morphogenesis, metabolism, steroid processing, transcription, and translation. All but one of the genes are similar to those in humans, and many are associated with disease. Knockdown of lin-52, a subunit of the Myb-MuvB transcription factor, or βNACtes6, a gene involved in protein folding and trafficking, resulted in a switch from cell proliferation to an endoreplication growth program through which wing tissue grew by an increase in cell size (hypertrophy). It is anticipated that further analysis of the genes that we have identified will reveal new mechanisms that regulate tissue growth during development.

Abstract. How do different aspects of students' self-relate to their development at school? In educational psychology, this question has been examined essentially only in terms of the influence of the ability self-concept, a central part of the personal self. Starting with a literature review on why and how the ability self-concept impacts motivation and student outcomes, we argue that social selves – learners' knowledge about their group memberships and associated evaluations – have an impact, too. Students are more intrinsically motivated and more successful if they experience fit between learning environment and important self-aspects. Accordingly, we suggest a model according to which students try to increase fit by exerting primary control, i. e., by proactively changing the environment, with the self as agent. To that end (i) they mentally project the self as different from the actual self, with the mental self-projection serving as a self-evaluative standard and motiving behaviors aiming at its attainment, (ii) they choose behavioral options that allow for the enactment of important self-aspects, (iii) they choose interaction partners who share important self-aspects or are supportive of their behavioral enactment, and (iv) they switch between or prioritize different values, to best match affordances and constraints of the learning environment. If a student repeatedly fails to achieve fit through primary control, secondary control strategies are deployed, i. e., internal processes aimed at minimizing losses and saving resources for the pursuit of more attainable goals. To that end, students either disidentify with the learning environment or redefine their selves in a reactive manner, with, in many cases, detrimental effects on their academic outcomes. We hope to inspire educational psychologists to more systematically investigate the different self-aspects' impact on social and academic development of learners at school.

In the mid-2000s, banks competed for leadership in the growth of new points of sale of services. Today, the positive for the bank is the closure of branches with a minimum physical presence in the administrative territory, while without reducing the number of clients. The purpose of the article is to analyze the situation in Ukraine on reforming network banks regarding their presence outside the head office, the possibility of maintaining branches in the structure of the bank (points of sale). The dynamics of the share of cash and non-cash transactions carried out by bank customers has been assessed. It was revealed that the expansion of the payment infrastructure and the network where payment cards are used affects the further fate of bank branches. During the quarantine period, under the influence of digitalization, the physical workload of on banks branches decreased due to the fact that today they (branches) are not the only points of sale of banking services. At the same time, most of the new functions arising from the digitalization of banking processes can be performed by the central offices of the bank. The popularity of internet acquiring is growing rapidly, the advantages of which are the speed of the operation, the absence of the need for the physical use of the payment card itself, the absence of the need for a POS terminal in the store, the possibility of making payments in 24/7 mode. The current trends in banking activity indicate that face-to-display and display-to-display communication will completely replace the modern understanding of banks. In the future, there will be new ways to store your own resources, for example, storage in “cloud technologies”; plastic cards will physically disappear, which will be replaced by tokens; cash will remain at a minimum level (within 2-5% of the amount of non-cash payments), which will be dealt with by SIT companies; lending will switch to P2P mode.

Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism ofArabidopsisseeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination.

The zero-tillage and minimum-tillage technologies, which are now being rapidly adopted in many areas of western Canada, have made a significant contribution to the sustainability of the soil resource. As a measure of economic viability of these practices this study uses the Top Management Model to simulate the 5-yr ending equity given stochastic prices and yields for a consensus farm in central Saskatchewan. Simulations are used to compare a minimum disturbance, zero-tillage system to a more conventional direct-seeding system. At 1994 crop and input prices, and a 10% yield advantage, zero-tillage systems compared favourably with conventional direct-seeding system. The relative crop yield and glyphosate price are key determinants to the short-run profitability of adopting zero-tillage technologies with fuel price having a smaller influence. When the switch to zero tillage allows a net reduction in machinery stock, this simultaneously increases the profitability, and reduces the financial risk for the producer. We conclude that in areas of Saskatchewan where zero-tillage systems provide a yield advantage, producers will continue to adopt these systems as an economically viable means of sustaining their soil resource. Key words: Adoption, zero tillage, economic determinants, herbicide prices, risk

Abstract Most irrigated lands of Central Asia suffer from land degradation, and unsustainable agricultural practices are one of the factors contributing to land degradation. Conservation agriculture (CA) is seen as a way to mitigate land degradation and rationalize resource use. The aim of this article is to investigate the efficiency of CA implementation in the Syrdarya province of Uzbekistan, Central Asia by carrying out a cost-benefit analysis (CBA). The CBA was conducted for a hypothetical situation where the farm decides to switch from conventional agriculture to CA. Unlike the previous studies, this study investigates complete crop rotation cycle in the long-term period. The study outcomes suggest that investment in CA implementation results in positive incremental benefit if the advantages of CA are monetized.

The Study investigates domestic energy utilization and potentials of alternative sources of energy in Mubi metropolis of Adamawa State. To achieve the objectives of this study, data were collected using questionnaire. A total of 108 sets of questionnaire were retrieved and analyse using descriptive statistics. Some of the data collected from respondents include; types of energy used for various purposes, factors that influence such use and preferences for the different types of energy. Other information which cannot be collected using questionnaire were obtained from published and unpublished materials. The findings show that households rely more on fuel-wood. Economic factors were found to influence the choice of energy used in homes. Solar energy and wind energy have high potentials as alternative energy source that will help in mitigating climatic change. The study concludes that households in Mubi metropolis tend to climb the energy ladder from low grade energy types to modern energy when income increases and such energy are made available. The study recommends that households be sensitized on the health and environmental effects of traditional energy. Households should be encouraged to use modern and alternative sources of energy in order to mitigate climate change. Such energies should also be made affordable and available since majority of the respondents were willing to switch when made affordable.
 Keywords: Domestic energy, alternative energy, climate change, firewood.
 
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Assigning multiple virtual network resources to physical network resources, called virtual network embedding (VNE), is known to be non-deterministic polynomial-time hard (NP-hard) problem. Currently software-defined networking (SDN) is gaining popularity in enterprise networks to improve the customizability and flexibility in network management service and reduced operational cost. A central controller in SDNs is an important factor that we need to take care of when we want to assign virtual networks to physical resources. In this work, we address virtual network embedding problems for SDNs. Indeed, our objective is to propose a method to assign virtual networks in the substrate network with minimum physical resources, and also minimizing delays between the virtual network controller and the switches in the virtual network. Our proposed algorithm considers the link and node constraints such as CPU and bandwidth constraints which is necessary to consider when we try to solve virtual network embedding problems.

Pursuing various sustainable development goals is posing new challenges for societies, policymakers, and researchers alike. This study implements an exploratory approach to address the complexity of food security and nuance its relationship with other grand challenges, such as energy use and climate change, in Central European countries. A multiple factor analysis (MFA) suggests that the three pillars of food security relate differently to climate change: food affordability and food accessibility positively correlate with climate change, while food quality has a negative association with temperature rise. However, if countries switched to renewable energy resources, all three pillars of food security could be achieved simultaneously. The study also underlines regional inequalities regarding grand challenges and emphasizes the need for innovative local solutions, i.e., advances in agriculture systems, educational programs, and the development of environmental technologies that consider social and economic issues.

The article is devoted to the study of the influence of mobile network settings on the energy consumption of electronic car control units. Signal quality and mobile network coverage are also important for both users and automotive devices that use real-time information from the network using cloud technologies to transmit, process and store data. For the quality of service measurements, Communications Regulatory Authority uses just HTTP data transmission (receipt) speed rate values in the operators’ UMTS (3G) networks (as CRA stated in annual report). But speed is not everything as many consumers in the industry are experiencing recently. In addition, improvements now also revolve about reducing the signaling load incurred when a radio bearer is established, modified or released. Another area for improvements is the signaling overhead on the air interface when little data is transferred as it consumes resources and causes battery drain from the mobile phone's point of view. The authors focused on the UMTS (the Universal Mobile Telecommunications System) 3G network, which is among the most popular 3G mobile communication technologies. We explore the RRC state machine of large cellular networks which operate in Lithuania. Note that in UMTS network, the centralized core network (CN) is responsible for ensuring switching and routing for the end users traffic. All Network management functions and required databases are also implemented in core network. The core network domain is further divided into sub categories: serving network domain, home network domain and the transit network domain. It consists of two kinds of General Packet Radio Service (GPRS) Support Nodes (GSNs), in 3GPP named as Gateway GSN (GGSN) and Serving GSN (SGSN) (Figure 1). SGSN is the central node of the packet switched (PS) domain. It provides for routing functionality and interacts with databases (like Home Location Register (HLR)) and manages many Radio Network Controllers (RNCs). So the authors were researching the RRC machines of Lithuanian cellular operators’ networks. The purpose of those experiments was to identify which network could provide a best user internet browsing experience, best user equipment battery consumption feature and best radio network resource utilization scheme. We can state, that comparing all these partitions, Operator2 has the optimal configuration for user experience, UE device battery consumption and network resource utilization of RRC state machine point of view.

Stone martens (Martes foina) are documented as generalist throughout their distributional range whose diet composition is affected by food availability. We tested if this occurs and what feeding strategies it follows in a typical Mediterranean ecosystem in Central Greece by analysing contents from 106 stomachs, seasonally collected from three different habitats during 2003–2006. Seasonal variation in diet and feeding strategies was evident and linked to seasonal nutritional requirements, but possibly imposed by strong interference competition and intraguild predation. Fleshy fruits and arthropods predominated in the diet, but also mammals and birds were frequently consumed. An overall low dietary niche breadth (BA=0.128) indicated a fruit specialization tendency. A generalised diet occurred in spring with high individual specialisation, whereas more animal-type prey was consumed than fruits. A population specialization towards fruits was indicated during summer and autumn, whereas insects were consumed occasionally by males. In those seasons it switched to more clumped food types such as fruits and insects. In winter it selectively exploited both adult and larvae insects and partially fruits overwinter on plants. The tendency to consume particular prey items seasonally reflected both the population specialist behaviour and the individual flexibility preyed on different food resources.

Kandri is Gunungpati administrative area in the district, which is located in the city of Semarang in Central Java province which have Kreo Caves Nature Area. The tourist area has now been developed with the construction of dam Artificial Jatibarang which was completed in 2014. The reservoir has sunk acres of farmland, resulting in most of the Kandri citizens lose their livelihoods as farmers, and switch to the efforts in the field of tourism. Kandri rural communities in the development of a tourist village has set up a group called Pokdarwis tourism awareness in the form of a tourism cluster. The tourism cluster not yet have an information system that is capable of managing a data member, as well as a means of product promotion and online sales. This research aims to design a cluster of business information systems, and implement into web technology. System development method used is prototype models. The information system is implemented using the programming language PHP and CodeIgniter framework with a MySQL database. Results of this research is an e-commerce information system that features business profile information management, resource development and asset cluster members. These systems also use social plugins that like facebook as a marketing tool products. Thus, the information system can be used as an online store business clusters, media promotion, and data center can yield information about the development of the classification of business entities SME cluster members, so it can be used by cluster administrators and stakeholdesr in monitoring the business development of its members.

During 2018–2019 Ukraine took part in the project of Food and Agriculture Organization (FAO) «Conservation and development of double-purpose cattle breeds in Eastern Europe» (TCP/RER/3604). The project covered Brown Carpathian and Brown Caucasian breeds of Armenia, Georgia and Ukraine. On the results of the project, experts from the FAO Regional Office for Europe and Central Asia, international experts prepared reports on gender, social and economic characteristics of the studied regions, genomic analysis of samples and provided recommendations for breeding in the regions with the breeds. It was considered expedient to present these results to the general scientific community.
 At each country FAO have chosen service-provider (organization), which should make survey on productive environment of targeted breed (in Ukraine – Brown Carpathian), conclude the general state of the breed, visit at least 100 farms where Caucasian/Carpathian Brown cattle breed was kept, collect information from 300 cows and 20 bulls, and genetic samples from at least 100 cows and 20 bulls kept for breeding. Service-provider in Ukraine was M.V.Zubets Institute of Animal Breeding and Genetics, NAAS.
 Scientists of M.V.Zubets Institute of Animal Breeding and Genetics and other sub-contracting organizations during February-June, 2019 investigated 265 heads of cattle in 31 villages 5 districts of the Transcarpathian region, phenotypically classified as Brown Carpathian breed, including 6 breeding bulls of mating age (1.5–2 years). Each animal was photographed, linearly descriptive features of the exterior were evaluated, the necessary body measurements were taken with the help of appropriate tools, live weight and constitutional features were determined, and samples were taken for genetic testing.
 A total of 554 hair samples were taken from the project (123 – from Armenia, 141 – from Georgia and 290 – from Ukraine).
 The basis for classifying the animals as Brown Carpathian was phenotypic examination and strict compliance with the main characteristics of the breed: uniform grey or brown colour with different shades of it, general conformation typical for the breed, lighter belt along the back, black muzzle with lighter hair around it, black hooves and horn tips, lighter "glasses" around the eyes, thick light hair inside outer ears.
 To form the genetic passport of the population, hair was selected from the tail switch of selected animals using equipment provided by FAO, sent to the laboratories of the International Atomic Energy Agency, Austria. In the laboratory in the district of Siebersdorf, DNA was isolated from the obtained samples, the genetic diversity of populations, the degree of inbreeding and their effective number, kinship between populations were assessed and the genetic structure and level of influence of other breeds were analysed.
 DNA was extracted from each hair follicle using a MasterPure kit (Biozym, Illumina, USA) according to the protocol of the Association of Public Health Laboratories (APHL). The isolated DNA was subjected to a two-step quality control procedure before preparation for wide-genome typing. DNA samples were measured using a Nanodrop spectrophotometer to obtain a concentration with a ratio of 260/280 and 260/230. According to the results obtained using a spectrophotometer, DNA samples were diluted to measure high-quality double-stranded DNA (dsDNA) by PicoGreen Assay. The final working DNA was prepared based on PicoGreen measurements and stored at – 20°C for further processing.
 Sample genotyping was performed using a third-generation 384-cell matrix to assess Bovine individuals on the Affymetrix-Axiom platform (Axiom Bovine Genotyping v3 array). Within the project, 48 individuals of Austrian Simmental and 18 – Ayrshire breeds were also genotyped for comparison. The matrix included 64.000 SNPs, providing a high probability of covering genomic variations of the Bos taurus and Bos indicus breeds.
 Intra-breed genetic diversity was assessed using PLINK v1.09 to calculate actual heterozygosity (H0) and inbreeding coefficient (FIS).
 Analysis of genetic parameters of population diversity evidenced a rather low inbreeding rate of Brown Carpathian breed and a fairly high effective population size compared to European breeds, which can indicate a very limited practice of artificial insemination and lack of selection among bulls.
 Analysis of genetic differentiation and relationship between populations, principal components analysis and determination of admixtures of other breeds proved the uniqueness of the Brown Carpathian breed from a genetic point of view.
 Based on the conducted genomic analysis of populations, consultations with project participants, reports of service providers of each country, an international consultant on animal genetic resources, chairman of the ICAR working group on functional traits, formed a breeding program for the studied populations. The breeding program included proposals for further selection work, calculation of basic selection-genetic parameters, selection effect, number of bulls and heifers for selection nucleus, number of doses to maintain genetic diversity of the population, cost of population restoration, breeding work of breeding centre and work plan by years to implement a breeding program.
 Gender analysis of service providers' reports showed some gender differentiation in livestock care, processing and everyday life of owners of Brown Carpathian cattle.

The strategy of price liberalization and privatization had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatization policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this study. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conduct.

Central Processing Unit (CPU) is the most significant resource and its scheduling is one of the main functions of an operating system. In timeshared systems, Round Robin (RR) is most widely used scheduling algorithm. The efficiency of RR algorithm is influenced by the quantum time, if quantum is small, there will be overheads of more context switches and if quantum time is large, then given algorithm will perform as First Come First Served (FCFS) in which there is more risk of starvation. In this paper, a new CPU scheduling algorithm is proposed named as Amended Dynamic Round Robin (ADRR) based on CPU burst time. The primary goal of ADRR is to improve the conventional RR scheduling algorithm using the active quantum time notion. Quantum time is cyclically adjusted based on CPU burst time. We evaluate and compare the performance of our proposed ADRR algorithm based on certain parameters such as, waiting time, turnaround time etc. and compare the performance of our proposed algorithm. Our numerical analysis and simulation results in MATLAB reveals that ADRR outperforms other well-known algorithms such as conventional Round Robin, Improved Round Robin (IRR), Optimum Multilevel Dynamic Round Robin (OMDRR) and Priority Based Round Robin (PRR)

Land subsidence is particularly critical in Tanggu, due to its flat-lying topography and large thickness of the soft clay. The subsidence up to 140mm/year reached its most critical state in the mid-1970s. To mitigate this hazard, some strict measures resulted in a drop in groundwater use, especially banning the exploitation of groundwater, were exerted. Accordingly, the subsidence indeed had a decreased trendy in this time interval. Meanwhile, a GPS-based monitor data also revealed that light uplift phenomena emerged in some individual monitor series. For discussing the relationship between this abnormality and the termination of groundwater, and analyzing the deformation characteristic after exerted this measure, this article with the aid of numerical method predicts the land subsidence. The result reveal that the settlement is ceased and obvious uplift phenomenon only emerges in the central region of the stop mining well, due to various supply resource the water level could have a rapid recovery after banning. Meanwhile, own to the time-dependant behavior of the soft layer and clay aquitard, the most region far form the ban well also emerges subside, but the subsidence rate switches to decreased trendy with time. Generally, the subsidence or uplift is stabilized in a finite time interval after the termination of groundwater pumping. Meanwhile, due to the different hydrogeologic and stratum conditions, the stabilized subsidence and uplift value are also different from unit 2 to unit 5.

To determine whether laying hens find the flicker of fluorescent light aversive, their preferences were tested individually in a two-room testing chamber in which each room could be illuminated by either incandescent or fluorescent lights. The rooms were joined by a central compartment which acted as a light baffle and through which the birds could easily pass. The level of illumination in the two rooms was carefully matched and other resources such as food, water and nest-boxes were available in both rooms. The preferences of 16 mature light hybrid hens which had experience of both fluorescent and incandescent lighting were recorded during a 6-h test period on each of 2 d with the light sources in the rooms being switched on the second day. Overhead video cameras recorded the position and the behaviour of the birds throughout testing. On each of the test days, the hens spent significantly more time in fluorescent light than they did in incandescent light (each day: P < 0.01). When data from both test days were combined, the birds spent on average 73.2% of their time under fluorescent light and only 26.8% under incandescent (P < 0.001). Frequency distributions of ingestive behaviour, nesting, preening, resting and walking indicated that the birds performed all activities in both rooms and in both types of light. These results indicate that the birds either did not perceive the flicker of the fluorescent lights or perceived the flicker and did not find it aversive, and that they found some aspect of the fluorescent light more attractive than incandescent. Key words: Lighting, fluorescent, incandescent, behaviour, poultry

Introduction Unplanned dialysis start (UPS) associates with worse clinical outcomes, higher utilisation of healthcare resources, lower chances to select dialysis modality and UPS patients typically commenced in-centre haemodialysis (HD) with central venous catheter (CVC). We evaluated patient outcomes and healthcare utilisation depending on initial dialysis access (CVC or PD catheter) and subsequent pathway of UPS patients. Methods In this study patient demographics, access procedures, hospitalisations, and major infectious complications were analysed over 12 months in 270 UPS patients. PD technique survival and impact of switching from HD to PD was examined along with logistic regression to investigate factors predicting AV fistula formation. Results 72 UPS patients started with PD catheter and 198 with CVC. PD patients were older and more comorbid but had a significantly lower number of access procedures while there was no difference in hospitalisation or major infections. 13/72 initial PD patients switched to HD and 1-year technique survival was 79%. 158/198 patients remained on HD and 73/158 reported permanent access formation. Older age, OR = 0.34 (CI, 0.17-0.68) and cardiac failure, OR = 0.31(CI, 0.13–0.78), were significant negative predictors of receiving fistula. Younger patients, OR = 0.29 (CI, 0.11–0.79) and those who received AVF, OR = 0.11 (CI, 0.03–0.38), had significantly lower odds of death. Discussion UPS with initial PD was possible in many patients and was associated with lower requirement for access procedures. AVF formation in UPS patients starting on HD was associated with better 1-year survival. Modality switching in UPS patients requires careful clinical management, including clinical practice patterns promoting permanent HD access formation.

Abstract. General circulation models (GCMs) have been widely used to simulate current and future climate at the global scale. However, the development of frameworks to apply GCMs to assess potential climate change impacts on regional hydrologic systems, ability to meet future water demand, and compliance with water resource regulations is more recent. In this study eight GCMs were bias-corrected and downscaled using the bias correction and stochastic analog (BCSA) downscaling method and then used, together with three ET0 methods and eight different water use scenarios, to drive an integrated hydrologic model previously developed for the Tampa Bay region in western central Florida. Variance-based sensitivity analysis showed that changes in projected streamflow were very sensitive to GCM selection, but relatively insensitive to ET0 method or water use scenario. Changes in projections of groundwater level were sensitive to both GCM and water use scenario, but relatively insensitive to ET0 method. Five of eight GCMs projected a decrease in streamflow and groundwater availability in the future regardless of water use scenario or ET method. For the business as usual water use scenario all eight GCMs indicated that, even with active water conservation programs, increases in public water demand projected for 2045 could not be met from ground and surface water supplies while achieving current groundwater level and surface water flow regulations. With adoption of 40 % wastewater reuse for public supply and active conservation four of the eight GCMs indicate that 2045 public water demand could be met while achieving current environmental regulations; however, drier climates would require a switch from groundwater to surface water use. These results indicate a high probability of a reduction in future freshwater supply in the Tampa Bay region if environmental regulations intended to protect current aquatic ecosystems do not adapt to the changing climate. Broad interpretation of the results of this study may be limited by the fact that all future water use scenarios assumed that increases in water demand would be the result of intensification of water use on existing agricultural, industrial, and urban lands. Future work should evaluate the impacts of a range of potential land use change scenarios, with associated water use change projections, over a larger number of GCMs.

Indonesia's transport system was formed largely based on the economic resource base of the archipelago, which consists of more than 17,800 Islands, on which the country is located. The Indonesian Central government's spending on transport has increased significantly in recent years. This allowed the country to expand its transport network and improve access to remote areas of the archipelago.
 Maritime navigation provides a link between different parts of the country. On some Islands, where there are no good roads, the main transport connection is via large rivers. The most important direction of the country's transport policy is the development of high-speed cargo and passenger sea connections with the most remote and inaccessible regions of the country, primarily with the Eastern part of Indonesia.
 A variety of vehicles are used on the roads of Indonesia. Bus routes are laid in all areas that have access to the road network. Since 2004, the TransJakarta rapid bus system has been operating in the country.
 Most of Indonesia's Railways are located in Java and are used for both passenger and freight transport.
 In March 2019, the Jakarta metro started operating.
 Indonesia's air transport is the most important means of communication between thousands of Islands throughout the archipelago and other countries. Many residents of the country have switched from land and sea transport to faster and more comfortable air transportation.
 Indonesia, like other countries, was severely affected by the COVID-19 pandemic in 2020. Further development of transport depends on how quickly the country recovers from the COVID-19 pandemic and how effectively the authorities deal with its consequences.

Indonesia’s transport system was formed largely based on the economic resource base of the archipelago, which consists of more than 17,800 Islands, on which the country is located. The Indonesian Central government’s spending on transport has increased significantly in recent years. This allowed the country to expand its transport network and improve access to remote areas of the archipelago. Maritime navigation provides a link between different parts of the country. On some Islands, where there are no good roads, the main transport connection is via large rivers. The most important direction of the country’s transport policy is the development of high-speed cargo and passenger sea connections with the most remote and inaccessible regions of the country, primarily with the Eastern part of Indonesia. A variety of vehicles are used on the roads of Indonesia. Bus routes are laid in all areas that have access to the road network. Since 2004, the TransJakarta rapid bus system has been operating in the country. Most of Indonesia’s Railways are located in Java and are used for both passenger and freight transport. In March 2019, the Jakarta metro started operating. Indonesia’s air transport is the most important means of communication between thousands of Islands throughout the archipelago and other countries. Many residents of the country have switched from land and sea transport to faster and more comfortable air transportation. Indonesia, like other countries, was severely affected by the COVID-19 pandemic in 2020. Further development of transport depends on how quickly the country recovers from the COVID-19 pandemic and how effectively the authorities deal with its consequences.

Abstract Introduction Immunoglobulin M monoclonal gammopathy of undetermined significance (IgM MGUS) is a relatively common pre-malignant condition that may progress to Waldenstrom macroglobulinemia (WM), an incurable low-grade non-Hodgkin lymphoma. The acquisition of genomic alterations in a multistep process of progression is likely a central mechanism responsible for the progression of IgM MGUS to WM, leading to increased tumor burden and end-organ damage. The exact role of the immune system in this process is still poorly characterized. The modulation of the immune system by malignant cells leading to anti-lymphoma immunity or immune evasion is a well-stablished principle associated with lymphoma survival and progression, respectively. The understanding of the pathobiology of IgM MGUS and WM has grown significantly over the last few years; however, most of the past research has focused on genetics and flow cytometric analysis of malignant cells. The introduction of CyTOF, a novel platform coupling mass spectometry with single-cell flow cytometry using antibody-metal isotope pairs, has allowed a broader single-cell analysis and the study of functional profiles. We here report the use of CyTOF technology to comprehensively profile the immune system of patients with IgM MGUS and WM. Methods Viably-cryopreserved (DMSO 10%) single-cell suspensions containing peripheral blood mononuclear cells from 15 patients (WM n=9 and IgM MGUS n=6) were used in this study. Recovered cells (1-3 x 106 per sample) were stained with a 30-parameter surface protein CyTOF panel designed to characterize multiple cell types and profile the immune system. Nucleated cellular events were identified using a DNA intercalator conjugated to natural abundance iridium (191Ir and 193Ir). Cisplatin (195Pt) was used for dead-live cell discrimination and calibration beads containing natural abundance cerium (140/142Ce), europium (151/153Eu), holmium (165Ho), and lutetium (175/176Lu) were used for normalization of the instrument signal. CyTOF analysis of normalized files was carried out using the Astrolabe Diagnostics platform. Cell clusters were assigned using the FlowSOM package and differential abundance analysis was performed using the edgeR package. Analysis is adjusted for multiple comparisons. Results The median live single-cell count for the entire cohort was 573,300 (range 50,681 to 869,727), representing a median of 81% (range 39% to 87%) of the total event counts [median 820,800 (range 130,452 to 1,000,000]. The cell count and the proportion of event count was similar in patients with WM or IgM MGUS. T cells represented 45.8% of the total events; granulocytes represented 31.3%; NK cells represented 8.6%; monocytes represented 8.1%; B cells represented 2.4% of the total events for the entire cohort. Figure 1 shows a heat map of different immune cell sub-types proportion per patient sample. A difference was noted in the proportion of monocytes (CD14+, CD16+) and B-cells when comparing patients with IgM MGUS and WM (figure 2). Patients with WM had a higher proportion of monocytes compared to IgM MGUS patients (p=0.05). A higher proportion of B-cells was noted in patients with IgM MGUS when compared to WM (4.2% vs 0.6%, p=0.01). When B-cells were sub-classified as naïve, transitional, non-switched memory, switched memory, and plasmablasts, the proportion of non-switched memory B-cells was higher in IgM MGUS compared to WM (p=0.05). While the results of this pilot study suggest important differences between IgM MGUS and WM as regards the immune repertoire, confirmatory studies are in progress in a larger cohort of patients. Conclusion To our knowledge, this is the first study of mass cytometry in patients with WM and IgM MGUS patients. A higher proportion of monocytes and lower proportion of memory B-cells was noted in patients with WM compared to IgM MGUS. CyTOF study of the immune profile in these patients is feasible and can potentially uncover relationships between cell types not typically associated with the disease progression continuum (IgM MGUS to WM). While definitive conclusion cannot be made using this dataset due to the small sample size, CyTOF is a powerful tool in the study of the immune profile of WM patients. Disclosures Gertz: Amgen: Consultancy; Abbvie: Consultancy; Apellis: Consultancy; annexon: Consultancy; spectrum: Consultancy, Honoraria; Teva: Consultancy; Alnylam: Honoraria; Physicians Education Resource: Consultancy; Ionis: Honoraria; janssen: Consultancy; celgene: Consultancy; Prothena: Honoraria; Research to Practice: Consultancy; Medscape: Consultancy. Kapoor:Celgene: Research Funding; Takeda: Research Funding. Ailawadhi:Takeda: Consultancy; Amgen: Consultancy; Janssen: Consultancy; Celgene: Consultancy; Pharmacyclics: Research Funding. Reeder:Affimed: Research Funding. Ansell:Seattle Genetics: Research Funding; Regeneron: Research Funding; Takeda: Research Funding; Pfizer: Research Funding; Merck & Co: Research Funding; Trillium: Research Funding; Affimed: Research Funding; LAM Therapeutics: Research Funding; Celldex: Research Funding; Bristol-Myers Squibb: Research Funding.

AimsIncreasing antibiotic resistant organisms combined with frequent, inappropriate use of antibiotics is giving rise to infections which may no longer be able to be treated1. The aim of this prevalence study was to audit antimicrobial prescribing at a Hospital against Trust antimicrobial policies to determine whether the rising trend in antimicrobial prescribing is appropriate.MethodsThe data was collected in a point prevalence manner; prescriptions that were active at the time of auditing were included and those which were discontinued or prescribed and not yet administered were excluded. A data collection template was designed and distributed to ward pharmacists with education on how to complete. The following parameters were audited; allergy status, antibiotic name, route, indication, duration, review date as well as the ward and speciality. Ward pharmacists assessed whether the prescription was in line with Trust guidelines/ID/Micro recommendations. Data was collected into a central database, as well time taken to audit.The audit standards were90% of patients prescribed an antimicrobial for an indication in line with Trust policy or ID/Micro90% of patients prescribed an antimicrobial for a duration in line with Trust policy or ID/Micro90% of patients have an allergy status documentedResults272 inpatient charts were reviewed. 153 of these patients (56%) were prescribed an antimicrobial.398 antibiotic prescriptions were included for audit. 38% of prescriptions were for medical/surgical prophylaxis. Prophylactic prescriptions were not included for further analysis. 85% of prescriptions had an indication documented either on the electronic chart (JAC) or written in the paper medical notes. 98% of prescriptions were as per policy or in line with recommendations from ID/Micro. 61% of prescriptions had a review date documented. 100% of patients had an allergy status documented. Average duration of antibiotic prescription was 8 days, range 1–50 days, median 5. 80% of prescriptions were IV. 70% of antimicrobial prescribing takes place in the ICU/cancer/transplant setting. Respiratory tract infections were the most common indication for antimicrobial prescribing, 35%. Amikacin was the most commonly prescribed antibiotic (15%), followed by piperacillin/tazobactam (14%). The audit cost in terms of pharmacist time was £763, at a total of 33 hours.ConclusionsPolicy compliant prescribing was very high at 98%; this figure is surprisingly high and poses questions as to the accuracy of data collection and whether bias was present. As a Trust we are now interested and will focus on improving intravenous to oral switches and reviewing and documenting patients’ antimicrobial therapy regularly. As a tertiary/quaternary centre we treat complicated immunocompromised patients; we are unlikely to lower the burden of infection. Approximately 75% of antimicrobial prescribing was in the ICU and cancer and transplant setting, however we must optimise the use of antimicrobials and demonstrate good antimicrobial stewardship. This data will act as a baseline for a subsequent audits which will be carried out using the newly implemented EPIC® patient management system.ReferenceGOV.UK. 2019. Antimicrobial Resistance (AMR). [ONLINE]Available at: https://www.gov.uk/government/collections/antimicrobial-resistance-amr-information-and-resources [Accessed 2 July 2019].

Abstract Background: Hereditary transthyretin amyloidosis (hATTR) is a rare, progressive, and fatal disease caused by the buildup of transthyretin-derived amyloid protein in major organs, predominantly affecting the peripheral nerves and heart. Inotersen, a second-generation antisense oligonucleotide targeting TTR mRNA, has shown efficacy and safety in patients with hATTR in a randomized, double-blind, placebo-controlled, phase 3 study, NEURO-TTR (ClinicalTrials.gov, NCT01737398; Benson NEJM 2018). Patients with hATTR amyloidosis who completed the NEURO-TTR study were eligible to receive inotersen for up to 5 years in a phase 3 open-label extension study (ClinicalTrials.gov, NCT02175004). Methods: In NEURO-TTR, patients were randomized 2:1 to receive inotersen (300-mg weekly subcutaneous doses) or placebo. In the open-label extension, patients continued inotersen (inotersen-inotersen) or switched from placebo to inotersen (placebo-inotersen). Evaluations included modified Neuropathy Impairment Score +7 neurophysiologic tests composite score (mNIS+7; higher scores indicate worse neuropathy), Norfolk Quality of Life-Diabetic Neuropathy questionnaire total score (Norfolk QoL-DN; higher scores indicate worse QoL), and adverse events (AEs). Cardiomyopathy (CM) was defined by a diagnosis of hATTR-CM at trial entry or by an interventricular wall thickness of 13 mm or more on transthoracic echocardiography at baseline, as ascertained by a central reader, or no known history of persistent hypertension (systolic blood pressure, ≥150 mm Hg) within 12 months before screening. Results : In the placebo-controlled, double-blind, phase 3 NEURO-TTR study, 112/172 patients were randomized and received inotersen. At baseline, patients were predominantly white (91.9%) males (68.6%) with a mean age of 59.2 years. A total of 67.4% had stage I (ambulatory) and 32.6% had stage II (ambulatory with assistance) disease. Inotersen-treated patients who had stage II disease had a longer duration of disease from diagnosis (40.9 vs 24.8 months, respectively) and from onset (72.6 vs 63.2 months, respectively) of hATTR polyneuropathy symptoms compared with placebo-treated patients who had stage II disease, indicating more advanced disease. A higher proportion of inotersen-treated patients had CM at baseline (67% vs 55%, respectively), and more severe CM, measured by higher NT-proBNP levels and longer duration of disease from hATTR-CM symptom onset, compared with placebo-treated patients. In the phase 3 open-label extension study as of Sept 15, 2017, 134 of 135 patients enrolled received ≥1 dose of inotersen. The mean age was 60.4 years and most patients were male (69.4%). Extended dosing with inotersen up to 27 months continued to improve mNIS+7 and Norfolk QoL-DN in the open-label extension compared to placebo-treated patients at week 66 in the double-blind NEURO-TTR study; mean changes from open-label extension baseline to open-label extension week 52 in the inotersen-inotersen group were 5.1 points for mNIS+7 (vs 25.5 for placebo-treated patients in the double-blind NEURO-TTR study) and 3.9 points for Norfolk QoL-DN (vs 10.7 for placebo-treated patients in the double-blind NEURO-TTR study). Initiation of inotersen in placebo-treated patients (placebo-inotersen) resulted in improvement in mNIS+7 and Norfolk QoL-DN by week 26. Few patients discontinued treatment because of AEs (inotersen-inotersen, 9%; placebo-inotersen, 4%). The rate of treatment-related serious AEs was low in both treatment groups (2% each). There was no evidence of increased risk for grade 4 thrombocytopenia or severe renal events with increased duration of exposure. We will present 2-year follow-up results from the open-label extension study. Conclusions: Results of the open-label extension show continued benefit, measured by mNIS+7 and Norfolk QoL-DN, and confirmed that earlier initiation of treatment is important for optimal clinical outcomes. No new safety concerns were identified. Results from the longer-term follow-up for the open-label extension will further elucidate how inotersen may benefit patients with hATTR amyloidosis. Disclosures Brannagan: Alnylam: Honoraria, Other: Investigator, Speakers Bureau; Ionis: Other: Investigator. Wang:Ionis: Other: Investigator, Speakers Bureau. Coelho:Prothena: Consultancy, Honoraria; Ionis: Consultancy, Other: Investigator; Alnylam: Consultancy, Honoraria, Other: Investigator; Pfizer: Consultancy, Honoraria, Other: Investigator. Waddington Cruz:Ionis: Honoraria; Genzyme/Sanofi: Honoraria; Pfizer: Honoraria. Polydefkis:Pfizer: Honoraria; Alnylam: Honoraria. Dyck:Ionis: Consultancy; Alnylam: Consultancy. Plante-Bordeneuve:Alnylam: Consultancy; Pfizer: Consultancy, Other: reimbursement for travel and meeting; Ionis: Other: reimbursement for travel and meeting. Berk:Ionis: Honoraria, Other: Investigator; Alnylam: Honoraria, Other: Investigator; Pfizer: Other: Investigator. Barroso:Pfizer: Consultancy, Honoraria, Other: Thaos registry, Speakers Bureau; Alnylam: Honoraria, Other: Investigator. Conceição:Alnylam: Consultancy, Honoraria, Speakers Bureau; Pfizer: Consultancy, Honoraria, Speakers Bureau; Sanofi: Honoraria, Speakers Bureau. Hughes:Ionis: Employment. Kwoh:Ionis: Employment. Jung:Ionis: Employment. Guthrie:Akcea: Employment. Pollock:Akcea: Employment. Benson:Ionis: Other: Investigator, Research Funding. Gertz:janssen: Consultancy; Teva: Consultancy; spectrum: Consultancy, Honoraria; Alnylam: Honoraria; Ionis: Honoraria; Amgen: Consultancy; annexon: Consultancy; Prothena: Honoraria; Research to Practice: Consultancy; Apellis: Consultancy; celgene: Consultancy; Abbvie: Consultancy; Medscape: Consultancy; Physicians Education Resource: Consultancy.

The pursuit of science is a wonderful journey of discovery along which there are a myriad of avenues to be explored. There have always been so many objects of fascination, so many questions to ask along the way, so many possibilities to understand new principles, that making the decision about which problem to address and then having the self-discipline to explore it in depth challenge all who practice the art. How then are we, as cell biologists, to cope with the mountain of information that is accumulating as we enter the twenty-first century? We now have the potential to decipher the primary sequences of every single cellular protein for several model organisms. Just how are we to put this information into an intelligible framework for understanding cell physiology? The turn of a century is a time at which we can permit ourselves the luxury of looking backwards as well as forwards. Where were we a century ago, what were the challenges that faced us then and how do these questions relate to our future goals? As a cell biologist standing on the threshold of the twentieth century, one must have had a similar feeling of elation and expectation to that which we have at the present time. The Theory of Cells had been established by Schleiden and Schwan in 1838–1839, and in the following fifty years it had led to unifying ideas about the nature of plants and animals, an understanding of embryonic development, and the mysteries of the fertilisation of the egg and genetic continuity in terms of ‘cellular immortality’. These were truly halcyon days. By the end of the nineteenth century many of the central principles of cell biology were firmly established. Virchow had maintained in 1855 that every cell is the offspring of a pre-existing parent cell, but the realisation that the cell nucleus is essential for this continuity had to wait another 30 years. By this time, Miecher had already made in 1871 his famous discovery of nuclein, a phosphorus-rich substance extracted from preparations of nuclei from sperm and pus cells, and over the next twenty years a spectrum of sophisticated dyes became available that facilitated the visualisation of not only nuclein but also asters, spindle fibres, and microsomal components of cytoplasm in fixed preparations of cells. The centrosome, discovered independently by Flemming in 1875 and Van Beneden in 1876, and named by Boveri in 1888, was already considered to be an autonomous organelle with a central role in cell division. The behaviour of chromosomes, centrosomes, astral fibres and spindle fibres throughout mitosis and meiosis had been described in exquisite detail. Galeotti had even concluded by 1893 that the unequal distribution of chromatin in cancer cells correlates with an inequality of the centrosomes and the development of abnormal spindles - a conclusion reinforced by others over a century later (Pihan et al., 1998; Lingle et al., 1998). It had taken 200 years following Leuwenhoek's first observation of sperm to Hertwig's demonstration in 1875 that fertilisation of the egg is accomplished by its union with one spermatozoon. This demonstration was rapidly followed by Van Beneden's discovery - eventually to unify genetics and cell biology - that the nuclei of germ cells each contain one half the number of chromosomes characteristic of body cells. By 1902, both Sutton and Boveri had realised that the behaviour of chromosomes in meiosis precisely parallels the behaviour of Mendel's genetic particles described some 35 years earlier. In many ways we have witnessed during the past 50 years, and particularly in the last quarter century, a series of exciting breakthroughs in establishing an understanding of genetic function and continuity that are comparable to those of the previous century in demonstrating cellular function and continuity. The determination of the structure of DNA in 1953 and the elucidation of the genetic code throughout the 1960s led to the rapid realisation of the code's universality. The parallel development of sophisticated techniques for studying the genetics of the model bacterium Escherichia coli and its plasmids and viruses paved the way for a new era in biology. We were soon to construct recombinant DNA molecules in vitro, propagate them and eventually express them in E. coli, taking full advantage of the universality of the code. The principles of cloning DNA molecules had been clearly enunciated by Berg and Hogness in the early 1970s, and I myself had the great fortune as a young post-doc to share in this excitement and participate in putting some of these principles into their early practice. By the end of that decade, genes had been cloned from a multitude of eukaryotes and, moreover, technologies had been developed by Maxam and Gilbert and by Sanger that enabled these cloned genes to be sequenced. The accelerating accumulation of knowledge enabled by these simple technical breakthroughs has been astounding, leading to the determination of the complete genome sequences of budding yeast, the nematode Caenorhabditis elegans and the fruit fly, Drosophila melanogaster, and the prospect of the complete human sequence within a few years. To date we have managed this accumulating wealth reasonably well. Cloned genes have allowed cell biologists access to the encoded proteins, and as a consequence we have a working knowledge of many cellular processes. The sub-cellular meanderings of molecules have been charted with increasing accuracy, and gene products have been positioned in regulatory pathways. The concerted application of genetic and molecular approaches has given new insights into cell biology. This is particularly evident from work on the yeasts, which have come into their own as model systems with our realisation of the extent to which cell biological processes have been conserved. Nevertheless, the resulting regulatory pathways that emerge from our current ways of looking at the cell are rather unidimensional, gene products being placed into linear pathways as a result of either molecular or genetic analyses. Our current views are often blind to the fact that the cell is a multidimensional structure whose components are arranged in space, have multiple contacts that change with time and can respond simultaneously to a multitude of signals. Glimpses of such complexity are emerging from studies in which microarrays of all the identified open reading frames (ORFs) from the complete budding yeast genome have been screened for changes in patterns of gene expression throughout the cell cycle or upon sporulation. Cell-cycle-dependent periodicity was found for 416 of the 6220 monitored ORFs, and over 25% of these genes were found to be clustered at particular chromosomal sites, which suggesting there are global chromosomal responses in transcriptional control (Cho et al., 1998). The study of sporulation is perhaps the first example of the application of this type of technology to a developmental process. It revealed that, of the 6220 genes, about 500 undergo repression and 500 induction in seven temporally distinct patterns during the sporulation process, identifying potential functions for many previously uncharacterised genes (Chu et al., 1998). These studies already reveal layers of complexity in the regulation of the levels of transcripts as cells prepare for and pass through the different stages of meiosis. How much more complex are these patterns likely to be when viewed in terms of proteins, and their interactions, locations and functions within the cell? It seems clear, however, that a wonderful molecular description of the events of meiosis that can match the cytological understanding revealed by the work of Van Beneden and Boveri one hundred years ago is within our grasp. The cataloguing of all cellular proteins is now feasible through a combination of 2D-gel analysis and mass spectrometry, from which molecular mass data can be correlated with the fragment sizes of peptides predicted from whole genome sequence data (the emerging field of proteomics). It is not an easy task, but it seems just a matter of time before we have all this information at our fingertips. Yet how can we know the functions of all these proteins and have a full 3D picture of how they interact within a cell and the dynamics with which they do so? Yeast may be the first eukaryote for which some of these problems can be approached. Its genome is six-times smaller than that of C. elegans and 200 times smaller than the human genome, and has the further advantage that the genes can be easily disrupted through homologous recombination. Thus the prospect of systematic gene deletion to study the function of the 3700 novel ORFs identified in the whole genome sequence is feasible for this organism (Winzeler et al., 1999). One group in particular has devised a multifaceted approach for doing this: the affected gene is simultaneously tagged with an in-frame transcriptional reporter and further modified to epitope tag the affected protein, which thus allows the latter to be immunolocalised within cells (Ross-MacDonald et al., 1999). We can thus see the glimmerings of a holistic, genome-wide, cell-wide unravelling of cellular physiology. Some of these approaches will be easily adaptable to higher organisms. We will soon have read-outs of RNA expression patterns in cells undergoing a variety of developmental and physiological programmes in normal and diseased states. The analysis of function and the identification of ORFs in higher eukaryotes are likely to be more problematic. However, solutions for the rapid assessment of the functions of novel genes are already emerging. New insights are coming from labs using double-stranded RNA to interfere with cellular processes in C. elegans. It was originally found in this organism that the injection of double-stranded RNA corresponding to part of the mRNA of a gene prevents the expression of that gene through a mechanism that currently remains mysterious (Fire, 1999). The technique works extremely well in the nematode and even in the fruit fly, but doubts had been cast as to whether it would ever be valuable in mammals. The recent finding that the technique does indeed work in the mouse may well accelerate programmes to identify gene function by circumventing the particularly lengthy procedures for disruption of mouse genes (Wianny and Zernicka-Goetz, 2000). The multiple layers of complexity revealed by these emerging studies give some indication of the computational power that will be needed to model the cell. Is it now time for a new breed of mathematical biologists to emerge? Our present generation of cellular and molecular biologists have lost sight of some of the basic principles of physical chemistry, and quantitative analyses are done poorly if at all. Should the quantification of reaction kinetics now come out of the traditional domain of enzymology and be applied to multiple cellular processes - if we are truly to understand the dynamics of the living cell? If the yeast cell is complex, then how much greater complexity will we find in multicellular eukaryotes, given all the potential for cell-cell interactions? These problems are perhaps most alluring in the field of development, in which many phenomena are now demanding attention at the cellular level. In recent decades we have seen classical embryological approaches supplemented by genetic analyses to define the components of many developmental signalling pathways. This has demonstrated the existence of a conserved collection of molecular switches that can be used in a variety of different developmental circumstances. We are perhaps reaching the limits at which conventional genetic analyses can interpret these processes: often the precise relationships between components of regulatory pathways is not clear. We require a better grasp of how the molecules within the pathways interact, which will require the concerted application of sub-cellular fractionation, to identify molecular complexes, and proteomics. This has to be achieved in a way that allows us to interpret the consequences of multiple signalling events between different cell types. In the introduction to his famous text The Cell in Development and Inheritance, E. B. Wilson wrote almost a century ago: ‘It has only recently become possible adequately to formulate the great problems of development and heredity in terms of cellular biology - indeed we can as yet do little more than so formulate them.’ Has our perspective changed during the past one hundred years? Are not these the same challenges that lie ahead for the twenty-first century? It is now rather like being Alice in Wonderland in a room with many doors, each of which marks the onset of a new journey. Undoubtedly, any of the doors will lead to remarkable opportunities, but to what extent can we, as Alice, rely upon drinking from the bottle, or eating the biscuit, that happens to be at hand? We will have to use the existing resources, but it will be fascinating to see what new ingenuities we can bring to bear to help us on our journey through Wonderland. I have the feeling that we are to witness conceptual challenges to the way we think about cell biology that we cannot yet begin to appreciate…but what I would give to be around in one hundred years time to witness the progress we have made on our journeys!

People show attention to cloud computing since it is efficient and scalable. But maintaining the stability of processing so many jobs in the cloud computing environment with load balancing is a very difficult problem and receives much attention by researchers. Load balancing in cloud computing platform has performance impact also. Good load balancing makes cloud computing more efficient and increases user satisfaction. This paper introduces a better load balance model for public cloud based on cloud partitioning concept with a switch mechanism to choose various strategies in different situations. The algorithm applies game theory to load balancing strategy and improves the efficiency in the public cloud environment. MCC is a concept which aims to mitigate these limitations by extending the capabilities of smart devices by employing cloud services, as required. In MCC both the data storage and processing occur external to the mobile device, while in cloud computing it is usually only the data storage which is external. In this following a some of these architectures as categorized in augmented execution, elastic partitioned/modularized applications, application mobility, ad-hoc mobile cloud and add a fifth category; cyber foraging. This system addresses whether MCC techniques can be used to extend the capabilities of resource-constrained mobile-devices to provide the illusion of infinite, elastic resources on demand. The existing system limitations of mobile-devices, and identified five key limited resources as being CPU, memory, battery, data usage and time. In this research explored existing solutions for these limitations and identified offloading computation and storage from the device as a possible solution.

Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U34-thiolation. Despite amino acid sufficiency, tRNA-thiolation deficient cells appear amino acid starved. In these cells, carbon flux towards nucleotide synthesis decreases, and trehalose synthesis increases, resulting in a starvation-like metabolic signature. Thiolation mutants have only minor translation defects. However, in these cells phosphate homeostasis genes are strongly down-regulated, resulting in an effectively phosphate-limited state. Reduced phosphate enforces a metabolic switch, where glucose-6-phosphate is routed towards storage carbohydrates. Notably, trehalose synthesis, which releases phosphate and thereby restores phosphate availability, is central to this metabolic rewiring. Thus, cells use thiolated tRNAs to perceive amino acid sufficiency, balance carbon and amino acid metabolic flux and grow optimally, by controlling phosphate availability. These results further biochemically explain how phosphate availability determines a switch to a ‘starvation-state’.

The article provides an analysis of a large-scale epidemic outbreak caused by human coronaviruses. The epidemiological situation in the world and the Russian Federation is analyzed, which forced specialists to significantly increase the level of epidemiological danger from coronaviruses. The epidemic situations of the incidence in six regions of the Central Black Earth Region are described, the dynamics and regional features of the spread and nature of the course of the new coronavirus infection Covid-19 are generalized and systematized. Some epidemiological aspects of this infection in the territory of the Voronezh region are described. The dynamics of the epidemic process is described and a number of epidemiological indicators are analyzed (daily increase in morbidity and mortality, distribution of the duration of lethal diseases, risk groups, etc.). The clinical and epidemiological features of the combined forms of infections are analyzed: the prevalence of a moderate course, the risk of complications in risk groups. The difficulty of verifying this infection from other viral infections based on the clinical picture, the high virulence and severity of the course has been established. It was shown that the mobilization of health care to combat coronavirus infection revealed the main thing: the health care system has resources and mechanisms through which it is possible to quickly switch to work in extreme conditions. New hospitals and beds, re-equipment with diagnostic and resuscitation equipment, accelerated retraining of doctors. All this was effective evidence that an adequate potential supply of resources will not only reduce the consequences of possible epidemics in the future, but also during the period outside the epidemic will help accelerate the adoption of effective decisions and improve the quality of medical care for the population.

Abstract Choosing suitable sleeping sites is a common challenge faced by animals across a range of taxa, with important implications for the space usage patterns of individuals, groups, and ultimately populations. A range of factors may affect these decisions, including access to resources nearby, shelter from the elements, safety from predators, territorial defense, and protection of offspring. We investigated the factors driving patterns of sleeping site use in wild Kalahari meerkats (Suricata suricatta), a cooperatively breeding, territorial mongoose species that forages on scattered resources and makes use of multiple sleeping sites (burrows). We found that meerkat groups used some burrows much more often than others. In particular, large burrows near the center of the territory were used more often than small and peripheral burrows, and groups became even more biased toward central burrows when rearing pups. Meerkats also used their sleeping burrows in a nonrandom order. When they changed sleeping burrows, they moved disproportionately to nearby burrows but did not always select the closest burrow. Burrow decisions also reflected responses to short-term conditions: rates of switching burrows increased after encounters with predators and when resources were depleted, whereas group splits were associated with a reduced probability of switching. The group’s dominant female appeared to have disproportionate influence over burrow decisions, as groups were more likely to switch burrows when her foraging success was low. Our results link behavioral and movement ecology to show that a multitude of environmental and social factors shape daily group decisions of where to spend the night.

Abstract Background Prolonged central line (CL) and urinary catheter (UC) use can increase risk of central line–associated bloodstream infection (CLABSI) and catheter-associated urinary tract infection (CAUTI). Methods This interventional study conducted in a 76-bed long-term acute care hospital (LTACH) in Southeast Michigan was divided into 3 periods: pre-intervention (January 2015–June 2015), intervention (July–November 2015), and postintervention (December 2015–March 2017). During the intervention period, a multidisciplinary infection prevention team (MIPT) made weekly recommendations to remove unnecessary CL/UC or switch to alternate urinary/intravenous access. Device utilization ratios (DURs) and infection rates were compared between the study periods. Interrupted time series (ITS) and 0-inflated poisson (ZIP) regression were used to analyze DUR and CLABSI/CAUTI data, respectively. Results UC-DUR was 31% in the pre- and postintervention periods and 21% in the intervention period. CL-DUR decreased from 46% (pre-intervention) to 39% (intervention) to 37% (postintervention). The results of ITS analysis indicated nonsignificant decrease and increase in level/trend in DURs coinciding with our intervention. The CAUTI rate per catheter-days did not decrease during intervention (4.36) compared with pre- (2.49) and postintervention (1.93). The CLABSI rate per catheter-days decreased by 73% during intervention (0.39) compared with pre-intervention (1.45). Rates again quadrupled postintervention (1.58). ZIP analysis indicated a beneficial effect of intervention on infection rates without reaching statistical significance. Conclusions We demonstrated that a workable MIPT initiative focusing on removal of unnecessary CL and UC can be easily implemented in an LTACH requiring minimal time and resources. A rebound increase in UC-DURs to pre-intervention levels after intervention end indicates that continued vigilance is required to maintain performance.

Abstract Physiology places constraints on an animal’s ability to forage and those unable to adapt to changing conditions may face increased challenges to reproduce and survive. As the global marine environment continues to change, small, air-breathing, endothermic marine predators such as otariids (fur seals and sea lions) and particularly females, who are constrained by central place foraging during breeding, may experience increased difficulties in successfully obtaining adequate food resources. We explored whether physiological limits of female otariids may be innately related to body morphology (fur seals vs sea lions) and/or dictate foraging strategies (epipelagic vs mesopelagic or benthic). We conducted a systematic review of the increased body of literature since the original reviews of Costa et al. (When does physiology limit the foraging behaviour of freely diving mammals? Int Congr Ser 2004;1275:359–366) and Arnould and Costa (Sea lions in drag, fur seals incognito: insights from the otariid deviants. In Sea Lions of the World Fairbanks. Alaska Sea Grant College Program, Alaska, USA, pp. 309–324, 2006) on behavioural (dive duration and depth) and physiological (total body oxygen stores and diving metabolic rates) parameters. We estimated calculated aerobic dive limit (cADL—estimated duration of aerobic dives) for species and used simulations to predict the proportion of dives that exceeded the cADL. We tested whether body morphology or foraging strategy was the primary predictor of these behavioural and physiological characteristics. We found that the foraging strategy compared to morphology was a better predictor of most parameters, including whether a species was more likely to exceed their cADL during a dive and the ratio of dive time to cADL. This suggests that benthic and mesopelagic divers are more likely to be foraging at their physiological capacity. For species operating near their physiological capacity (regularly exceeding their cADL), the ability to switch strategies is limited as the cost of foraging deeper and longer is disproportionally high, unless it is accompanied by physiological adaptations. It is proposed that some otariids may not have the ability to switch foraging strategies and so be unable adapt to a changing oceanic ecosystem.

The urgency of the problem of distance education development is caused by the fact that in modern conditions the requirements for specialists are radically changing. At the same time, the central place is not the use of previously acquired knowledge, but the generation and implementation of new ideas, which dictates new requirements for training. In this regard, lifelong learning becomes increasingly necessary, acquires new forms and meanings. Today, advances in information technology and telecommunications allow the development of distance learning as a kind of continuing education that accompanies the information society, because it forms a comprehensively developed personality, able to navigate in the information environment.
 The pandemic forced universities to switch to e-Learning in a force majeure mode, which served as a powerful impetus for the accelerated arming of universities with resources that allow them to effectively practice online and blended learning. In these conditions, it became possible to implement a student-centered educational paradigm. However, this is hindered by the problem of the student's lack of self-organization and self-motivation skills, the ability to take responsibility for their own learning and development. This problem is gaining more and more theoretical and practical importance. The purpose of the work is to substantiate that courses such as self-management and time management contribute to the formation of competencies in the field of goal-setting, planning, self-organization, self-control and self-motivation, and, therefore, in the context of the implementation of student-centered pagadigma, they should serve as preliminary study for e-Learning. For this, the article provides a review of the "Time Management" content course in relation to the task of developing proactivity and the student’s ability to systematically and productively independent work.

Perception is central to the survival of an individual for many reasons, especially as it affects the ability to gather resources. Consequently, costs associated with perception are partially shaped by resource availability. Understanding the interplay of environmental factors (such as the density and distribution of resources) with species-specific factors (such as growth rate, mutation, and metabolic costs) allows the exploration of possible trajectories by which perception may evolve. Here, we used an agent-based foraging model with a context-dependent movement strategy in which each agent switches between undirected and directed movement based on its perception of resources. This switching behavior is central to our goal of exploring how environmental and species-specific factors determine the evolution and maintenance of perception in an ecological system. We observed a non-linear response in the evolved perceptual ranges as a function of parameters in our model. Overall, we identified two groups of parameters, one of which promotes evolution of perception and another group that restricts it. We found that resource density, basal energy cost, perceptual cost and mutation rate were the best predictors of the resultant perceptual range distribution, but detailed exploration indicated that individual parameters affect different parts of the distribution in different ways.

Abstract After the translating of the worldwide pandemic coronavirus disease 2019 (COVID-19) disease from South East Asia to Europe, North African countries accelerate their steps to follow WHO guidelines to prepare the outbreak response. In March 2020, the Tunisian Ministry of Health switched Abderrahmen Mami Hospital to a COVID-19 center. The main objectives were management of patients but also setting-up new rules to permit enough safety for the staff members and harmony between medical, nonmedical, and administrative departments within the facility. Organization and communication during the fast-paced preparation process were crucial to get enough qualified human resources, material resources, and clear procedural texts in place before cases arrived in huge numbers. A group of medical and administrative experts within a central crisis unit brought this challenge into reality.

Dry beans are an agricultural product within the legume family. It is a product included in irrigated farming systems and has a higher profit margin compared to other products. It is an important resource in meeting the protein needs of people with low income. In this study, dry bean projections with the ARIMA model have been made for the provinces of Central Anatolia Region and Turkey in general. The ARIMA model projected that there was an important volatility in the dry bean production areas over the years. As a result of the estimations, although a rising trend in the period up to 2023, especially after the estimate was made in 2021 will again switch to a down trend. In the light of the information obtained, it is recommended to eliminate the factors that will adversely affect the producer's production decisions. It is recommended to further support cost factors to provide price stability and to examine the actors in the supply chain.

AbstractDuring European states’ development, various past societies utilized natural resources, but their impact was not uniformly spatially and temporally distributed. Considerable changes resulted in landscape fragmentation, especially during the Middle Ages. Changes in state advances that affected the local economy significantly drove trajectories of ecosystems’ development. The legacy of major changes from pristine forest to farming is visible in natural archives as novel ecosystems. Here, we present a high-resolution densely dated multi-proxy study covering the last 1500 years from a peatland located in CE Europe. The economic activity of medieval societies was highly modified by new rulers—the Joannites (the Order of St. John of Jerusalem, Knights Hospitaller). We studied the record of these directorial changes noted in the peat profile. Our research revealed a rapid critical land-use transition in the late Middle Ages and its consequences on the peatland ecosystem. The shift from the virgin forest with regular local fires to agriculture correlates well with the raising of local economy and deforestations. Along with the emerging openness, the wetland switched from alkaline wet fen state to acidic, drier Sphagnum-dominated peatland. Our data show how closely the ecological state of wetlands relates to forest microclimate. We identified a significant impact of the Joannites who used the novel farming organization. Our results revealed the surprisingly fast rate of how feudal economy eliminated pristine nature from the studied area and created novel anthroecosystems.

Fibromyalgia (FM) is a disorder of central pain processing marked by widespread chronic pain together with fatigue, sleep disturbances, cognitive dysfunction, and depressive episodes. Tested treatments have expressed limited efficacy. Oxidative stress plays a role in the pathology of FM, while multiple neurotransmitters are involved in this syndrome. Antidepressants are used as conventional treatment, especially those with double action on serotonin and norepinephrine that leads to an increased risk of a manic switch. It should be noted that fibromyalgia is high-frequency comorbidity in bipolar disorder. This narrative review, given the limited literature, consisted of animal and in vitro studies, which aims to highlight the positive aspects of Hypericum scruglii as a potential remedy against FM. Many in vitro and clinical studies confirm the Hypericum genus as a natural antidepressant resource. The use of Hypericum derivatives in various acute and chronic diseases has been known for a long time. It is reported that the phloroglucinol derivatives from Hypericum longistylum improve and accelerate the differentiation of neural progenitor cells. The advantage of Hypericum scruglii is that it owns greater antioxidant potential than other species of the Hypericum genus. Suggestions for improving the oral bioavailability of very poor water-soluble molecules of hypericum extracts are also described in this paper.

Background: Metoprolol is a commonly prescribed β-blocker for hypertension in the US. Evidence suggests that the vasodilating β1-blocker, nebivolol, is superior to non-vasodilating beta-blockers, such as metoprolol, in lowering central blood pressure, an effect which is thought to be highly correlated to future cardiovascular (CV) risk. The aim of this study was to evaluate CV-related healthcare resource utilization (HCRU) and costs before and after patients switched from metoprolol to nebivolol for hypertension treatment. Methods: This retrospective study utilized medical and pharmacy claims from HealthCore-Integrated-Research-Database with 14 US commercial health plans representing over 33 million lives. The study cohort included only patients who were initially taking metoprolol for at least 6 months (pre-period) and then switched to nebivolol and remained on it for at least 6 months (post-period). The date of switching to nebivolol between 1/1/ 2008 and 12/31/2012 was defined as the index date. Patients were excluded if they had angina, myocardial infarction and congestive heart failure (compelling indications for metoprolol but not for nebivolol); unstable regimen of background antihypertensive medication at the drug class level; or did not have continuous health plan enrollment during these two periods. CV-related HCRU (per-100 patient-per-month) and costs (per-patient-per-month (PPPM)) were calculated for pre- and post- periods respectively by type of service - hospitalizations (INP), emergency room (ER) visits, and outpatient (OP) visits. Bootstrapping t-test was used to compare the differences of HCRU and costs between these two periods. Results: There were 765 patients included in the study with mean age 55(±11)years, 59% males and mean Deyo-Charlson Comorbidity Index (DCI) score of 0.5(±0.9). Relative to pre-period, the number of CV-related ER visits and CV-related OP visits per-100 patient-per-month were significantly lower in the post-period (ER: 0.17±1.88 vs.0.04±0.84, p=0.012; OP: 9.2±19.9 vs. 6.7±17.5, p<0.001). No differences were observed in number of CV-related INP visits. Additionally, relative to the pre-period, the ER cost and the total CV-related medical were significantly lower in the post-period (ER: $6 ±$78 vs. $1±$27 PPPM, p=0.028; total CV-related medical costs: $94±$526 vs. $54±$266 PPPM, p=0.020). There were no differences found in INP or OP costs. Conclusions: This study suggests that hypertensive patients switching from metoprolol to nebivolol have lower CV-related ER and OP visits as well as lower total CV-related medical costs, despite higher pharmacy costs after switching from a generic to a branded drug. Further studies are needed to identify these key drivers.

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this study. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conduct.