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Dissertations / Theses on the topic 'Syk Inhibitor'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Yamamoto, Noriyuki. "Development of a selective inhibitor for Syk tyrosine kinase and investigation of its pharmacological activities." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148369.

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2

Roders, Nathalie. "Régulation de l'activation de lymphocytes B / cellules plasmatiques pendant le rejet chronique : Le rôle de SYK dans la modulation de Mcl-1." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS439/document.

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L'insuffisance rénale est un problème majeur de santé publique et la transplantation rénale est l’option thérapeutique principale, mais elle comporte le risque de rejet d'organe. Les cellules B jouent un rôle important dans le rejet médié par les anticorps (AMR). Au cours de l'AMR chronique, les structures lymphoïdes tertiaires, semblables aux centres germinatifs (GC), apparaissent dans l'organe rejeté, associées à la production des plasmocytes et des lymphocytes B mémoires spécifiques du donneur. Ces populations de lymphocyte B sont souvent mal contrôlées par les traitements actuels. La myelo

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3

Abadleh, Mohammed Mustafa Mohammed. "Diarylisoxazole als Leitstruktur für Design und Synthese von Proteinkinase Inhibitoren = Diarylisoxazoles as lead for the design and synthesis of protein kinase inhibitors /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000276718.

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4

Xu, Mingming. "Discovery of inhibitors against a-synuclein aggregation." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/392373.

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Abnormal protein aggregation has been linked to many neurodegenerative diseases, including Parkinson’s disease (PD). The main pathological hallmark of PD is the formation of Lewy bodies and Lewy neurites, both containing the pre-synaptic protein α-synuclein (α-syn). Native α-syn, under normal conditions, exists in a soluble unfolded state but undergoes misfolding and aggregation into toxic aggregates under pathological conditions. Toxic α-syn species can cause oxidative stress, membrane penetration, synaptic and mitochondrial dysfunction, leading to neuronal death and eventually neurodegenerat

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5

Coombes, Susan. "Boards of directors and nonprofit entrepreneurial orientation Catalyst, inhibitor, or inconsequential /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.

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6

Bracht, Kathrin. "Neue Inhibitoren zellmembranständiger Proteinkinasen /." Konstanz, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252796.

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7

Cohen, Jason C. "Attention mechanisms and inhibition of return in the somatosensory system." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2002. http://wwwlib.umi.com/cr/syr/main.

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8

Amanovic, Ilijana. "Ginkgo biloba extract inhibits tissue factor degradation /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278514.

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9

Wollmann, Heike. "MiRNA targeting mechanisms - translation inhibition versus transcript cleavage /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000251923.

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10

Rango, Enrico. "PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1140389.

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The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity profile against neuroblastoma (NB) and glioblastoma (GBM) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, the good antitumor activity of Si306 is associated with sub-optimal aqueous solubility, which might hinder its further development. In this context, drug delivery systems were developed to overcome the poor

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11

Bühler, Nico Martin. "Selektive COX-2 Inhibitoren und Nierenschädigung bei salzsensitiver Hypertonie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000297941.

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12

Grässlin, Anja. "Protein epitope mimetics as inhibitors of protein-protein interactions and in synthetic vaccine design /." Zürich, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254199.

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13

Eichenauer, Dennis Alexander. "ADAM10 als CD30-Sheddase und immuntherapeutische Möglichkeitenn durch ihre Inhibition /." Köln, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252839.

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14

Zhou, Bin. "Disentangling perceptual and motor components in inhibition of return (IOR) /." München, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253469.

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15

Haase, Ludwig Christoph Benedikt. "Effektivität und Interaktionen von Flavopiridol, einem Inhibitor cyclin-abhängiger Kinasen, mit Methotrexat, Adriamycin und Cisplatin beim Harnblasenkarzinom in vitro /." Bonn, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253878.

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16

Raithel, Kerstin. "Effekt von S-Lost in HaCaT-Zellkulturen : Induktion der Apoptose und Effekt eines PARP-Inhibitors /." München, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254372.

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17

Gisler, Fabian. "Effectiveness of angiotensin-converting enzyme inhibitors in pediatric patients with mid to severe aortic value regurgitation /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000281144.

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18

Schreml, Stephan. "Antiproliferative und antiinflammatorische Aktivität von mTOR-Inhibitoren : Untersuchung an humanen organspezifischen Endothelzellkulturen /." Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254339.

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19

Sommer, Eeva. "Exploring the contribution of SGK isoforms to signalling and mediating resistance to Akt inhibitors in breast cancer cells." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/675ced8f-7a4d-467c-b1f2-cc0796f08f6e.

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20

Eklund, Hans. "Inhibition : om verkställighetsförbud m.m. i judiciell process, inom förvaltningsrätten och i utsökningsförfarandet /." Uppsala : Iustus Förl, 1998. http://www.gbv.de/dms/spk/sbb/recht/toc/272701300.pdf.

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21

Koeberle, Andreas. "Identification and characterization of microsomal prostaglandin E₂ synthase-1 inhibitors = Identifizierung und Charakterisierung von Hemmstoffen der mikrosomalen Prostaglandin E₂ Synthase-1 /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278394.

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22

Fink, Kerstin. "Intestinale kommensale Bakterien als potentielle Inhibitoren oder Aktivatoren einer CD4⁺ T-Zell-induzierten Kolitis in Rag1-/- Mäusen /." Tübingen, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253090.

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23

Ziegler, Katharina. "Tetrasubstituierte Imidazole als ATP-kompetitive p38 MAP Kinase Inhibitoren: Synthese, biologische Testung und Untersuchung zur metabolischen Stabilität /." Tübingen, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253679.

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24

Fertmann, Jan Michael. "Untersuchungen zu den Auswirkungen der Inhibition der No-Synthase in einem In-vivo-Modell des regionalen myokardialen Ischämie-/Reperfusionsschadens /." München, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253658.

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25

Maass, Elke. "Einfluss von selektiven und nicht-selektiven COX-2-Inhibitoren in Kombination mit Cisplatin auf das Wachstumsverhalten oraler Plattenpithelkarzinomzellen in vitro /." Köln, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254550.

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26

Ampem, Prince Tuffour. "Mechanism Underlying the Inhibitory Effect of Nitrative Stress on the Sulfation of Dopamine and its Methylated Product by Human SK-N-MC Neuroblastoma Cells." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333675845.

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27

Forster, Laura. "Entwicklung eines Assays zur Bestimmung der Aktivität von Hemmstoffen der Fatty Acid Amide Hydrolase (FAAH) und Synthese neuartiger Inhibitoren des Enzyms /." Münster, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252266.

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28

Wächter, Michael. "Herstellung von optisch aktiven Organophosphaten mit cis- und trans-Decalingerüst zur Untersuchung der Inhibition von Acetylcholinesterase mittels Enzymkinetik und ³¹P-NMR Spektroskopie /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000282906.

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29

Carlo, Zuddas. "Surface antigenic changes in P.falciparum infected erythrocytes following treatment with Syk inhibitors and Artemisinin." Doctoral thesis, 2020. http://hdl.handle.net/11562/1018318.

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The human Plasmodium falciparum (P.falciparum) parasite, currently infects more than 200 million people annually, causing about 500 000 deaths a year and imposes considerable morbidity on the surviving population. Since 2001, the WHO has recommended Artemisinin based combination therapies (ACTs) as treatment of choice for falciparum malaria. However the WHO has observed foci of suspected artemisinin resistance in South- east Asia. Because strains of P. falciparum are rapidly emerging that are resistant to all known antimalarial drugs, including artemisinin, quinine, chloroquine, piperaquine, a

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30

Tsamesidis, Ioannis. "Mechanism of synergic interaction of Syk inhibitors on antimalarial artemisinin activity." Doctoral thesis, 2018. http://hdl.handle.net/11562/978967.

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The primary objective of malaria treatment is to eradicate the disease, which involves rapid and complete elimination of the Plasmodium parasite from the patients’ blood. Artemisinin combination therapies (ACTs) are the mainstay of recommended treatment for P. falciparum malaria and as no alternatives to artemisinin derivatives are expected to enter the market for several years, their efficacy must be preserved. Unfortunately, the resistance to ACTs, is a major thread for the control and elimination of malaria due to P. falciparum. The need for new antimalarial drugs is more urgent than ever b

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31

Castellanos, Penton Patricia. "Syk Inhibition Attenuates Airway Hyperresponsiveness in a Murine Model of Asthma and Exacerbation by Air Pollution." Thesis, 2012. http://hdl.handle.net/1807/33357.

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Airway hyperresponsiveness (AHR) is a cardinal feature of asthma that is aggravated by environmental air pollution (EAP). Splenocyte tyrosine kinase Syk has been associated with asthma pathogenesis. Therefore, we sought to investigate the effect of Syk inhibition on AHR and its exacerbation by EAP. For this purpose, we examined Syk protein expression in lung homogenates from three murine models of ovalbumin (OVA)-induced asthma expressing different pathophysiological features of the disease: airway inflammation, AHR and remodeling. Increased Syk expression was observed only in the chronic mode

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32

Chen, Ching-Wen, and 陳菁雯. "PART I. Inhibition of interferon-gamma-mediated JAK-STAT signaling pathways by endonuclease inhibitor aurintricarboxylic acid and PPARg agonist 15dPGJ2 PART II. Signaling pathways of vanilloid receptor-independent inhibition of inducible nitric oxide syn." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/66451291613409478132.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>90<br>Inducible nitric oxide (iNOS) is thought to involve in host defense and tissue damage in inflammatory loci. In previous study, we have found that the endonuclease inhibitor aurintricarboxylic acid (ATA) can protect macrophages from cell death induced by bacterial lipopolysaccharide. This action is through the interruption with signaling pathways for NF-kB and AP-1 activation, and thus iNOS expression. In this study we have addressed the effects of ATA on JAK-STAT signaling pathways. In murine RAW 264.7 macrophages, IFN-g-mediated NO production and iNOS expressio

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33

VANÍČKOVÁ, Martina. "Detekce a kvantifikace inhibitorů proteáz v klíštěti \kur{Ixodes ricinus} pomocí monoklonálních protilátek." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-381504.

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Inhibitors of proteases in tick saliva play an important role during tick feeding. Tick saliva contains a wide range of bioactive components which are able to modulate host imunity. Therefore, ticks are able to feed for a long time and transfer tick-borne diseases pathogens. The risk of transfer can be significantly reduced by deactivation of theese protease inhibitors. In this study I made monoclonal antibodies for detection and quantification of two serine protease inhibitors in tick saliva and other tick-body parts.

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34

(10716546), Panae Noomuna. "INHIBITION OF ERYTHROCYTE BAND 3 TYROSINE PHOSPHORYLATION: CHARACTERIZATION OF A NOVEL THERAPY FOR SICKLE CELL DISEASE AND MALARIA." Thesis, 2021.

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While the molecular defect that cause sickle cell disease has well been established, the cause of vaso-occlusive crisis remains elusive and largely debated upon. Majority of studies have linked the painful episodes to polymerization of sickle hemoglobin following its deoxygenation. The variability of the disease symptoms among patients, compounds efforts for a holistic therapy. Hydroxyurea, a stimulator of Hb F induction and a widely used treatment, has ameliorated the complication of SCD but it is only effective in 50% of the patients. Expression of Hb F lowers the content of Hb S in blood an

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35

"Prevention of inorganic scale formation in off-shore oil exploration: applications of the ppca inhibitor." Tese, MAXWELL, 2002. http://www.maxwell.lambda.ele.puc-rio.br/cgi-bin/db2www/PRG_0991.D2W/SHOW?Cont=3663:pt&Mat=&Sys=&Nr=&Fun=&CdLinPrg=pt.

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36

Font, Haro Albert. "Modulace funkce plazmacytoidních dendritických buněk: role immunoreceptorů TIM-3 a BDCA-2." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-447158.

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Albert Font Haro ABSTRACT Modulation of plasmacytoid dendritic cell function: role of immunoreceptors TIM-3 and BDCA-2 Plasmacytoid dendritic cells (pDCs) are key players in the antiviral response as well as in linking innate and adaptive immune response. They express endosomal toll-like receptors 7 and 9, which can detect ssRNA and unmethylated CpG DNA, respectively. Due to the constitutive expression of the transcription factor IRF7, pDCs are able to rapidly produce massive quantities of type I (α, β, ω) and type III (1, 2, 3, 4) interferons (IFN-I and IFN-III) as well as pro- inflammato

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