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Journal articles on the topic 'Symptom Resolution'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sansotta, Naire, Karine Amirikian, Stefano Guandalini, and Hilary Jericho. "Celiac Disease Symptom Resolution." Journal of Pediatric Gastroenterology and Nutrition 66, no. 1 (2018): 48–52. http://dx.doi.org/10.1097/mpg.0000000000001634.

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Smulligan, Katherine, Mathew Wingerson, Corrine Seehusen, Julie Wilson, and David R. Howell. "Examining Initial Post-Concussion Dizziness and Postural Stability as Potential Recovery Predictors." Neurology 98, no. 1 Supplement 1 (2021): S17.1—S17. http://dx.doi.org/10.1212/01.wnl.0000801892.78481.b1.

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ObjectiveTo examine the association between acute post-concussion dizziness, initial symptom severity, and postural stability with time to symptom resolution among adolescents.BackgroundIdentifying early post-concussion symptoms and functional deficits that predict symptom resolution can guide treatment strategies. Dizziness is among the most common concussion symptoms, and existing literature investigating the association between dizziness and recovery time is mixed.Design/MethodsParticipants underwent initial evaluation = 14 days post-concussion, and self-reported symptom severity using the

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Marrie, Thomas J., Michael Beecroft, Zeljka Herman-Gnjidic, and Melanie Poulin-Costello. "Symptom Resolution in Patients withMycoplasma pneumoniaePneumonia." Canadian Respiratory Journal 11, no. 8 (2004): 573–77. http://dx.doi.org/10.1155/2004/659187.

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BACKGROUND:Mycoplasma pneumoniaegenerally causes pneumonia of mild to moderate severity in adults. However, little is known about the time course of the resolution of symptoms in this illness.OBJECTIVES:To determine the time course of the resolution of symptoms inM pneumoniaepneumonia.METHODS:The severity of fatigue, cough, dyspnea, sputum and pleuritic chest pain were self-scored and recorded daily for 14 days and on days 30 and 42. Each symptom was scored on a scale of 0 to 5. The sum of the five symptom scores had a range of 0 to 25 and was transformed into a value from zero to 100 by multi

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Grubenhoff, J. A., S. J. Deakyne, L. Brou, L. Bajaj, R. D. Comstock, and M. W. Kirkwood. "Acute Concussion Symptom Severity and Delayed Symptom Resolution." PEDIATRICS 134, no. 1 (2014): 54–62. http://dx.doi.org/10.1542/peds.2013-2988.

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Chew, Kara W., Carlee Moser, Eunice Yeh, et al. "Validity and Characterization of Time to Symptom Resolution Outcome Measures in the ACTIV-2/A5401 Outpatient COVID-19 Treatment Trial." Journal of Infectious Diseases 228, Supplement_2 (2023): S83—S91. http://dx.doi.org/10.1093/infdis/jiad300.

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Abstract Background Time to symptom resolution measures were used in outpatient coronavirus disease 2019 (COVID-19) treatment trials without prior validation. Methods ACTIV-2/A5401 trial participants completed a COVID-19 diary assessing 13 targeted symptoms and global experience (overall COVID-19 symptoms, return to pre–COVID-19 health) daily for 29 days. We evaluated concordance of time to sustained (2 days) resolution of all targeted symptoms (TSR) with resolution of overall symptoms and return to health in participants receiving placebo. Results The analysis included 77 high-risk and 81 sta

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Millichap, J. Gordon, and John J. Millichap. "Concussion Severity and Symptom Resolution." Pediatric Neurology Briefs 28, no. 8 (2014): 64. http://dx.doi.org/10.15844/pedneurbriefs-28-8-10.

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Lanois, Corey, Francis Wang, Brant Berkstresser, Jessie Oldham, William Meehan, and David Howell. "Acute post-concussion anxiety and depression scores are not associated with duration of concussion symptoms among collegiate athletes." Neurology 93, no. 14 Supplement 1 (2019): S12.2—S12. http://dx.doi.org/10.1212/01.wnl.0000580944.99412.91.

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ObjectiveTo investigate the association between acute post-injury scores on the Hospital Anxiety and Depression Scale (HADS) and symptom duration in collegiate student-athletes following a concussion.BackgroundConcussion recovery as measured by symptom resolution generally occurs within a week of injury in most athletes. In some cases, however, symptoms can persist for weeks or months. Time to symptom resolution has been associated with many factors, including psychological health. Athletes with a history of psychiatric or mood disorders prior to injury may be more likely to experience prolong

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McIntyre, Roger S., Carl Gommoll, Changzheng Chen, and Adam Ruth. "The efficacy of levomilnacipran ER across symptoms of major depressive disorder: a post hoc analysis of 5 randomized, double-blind, placebo-controlled trials." CNS Spectrums 21, no. 5 (2016): 385–92. http://dx.doi.org/10.1017/s1092852915000899.

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ObjectiveA post hoc analysis evaluated the effects of levomilnacipran ER on individual symptoms and symptom domains in adults with major depressive disorder (MDD).MethodsData were pooled from 5 Phase III trials comprising 2598 patients. Effects on depression symptoms were analyzed based on change from baseline in individual Montgomery–Åsberg Depression Rating Scale (MADRS) item scores. A1dditional evaluations included resolution of individual symptoms (defined as a MADRS item score ≤1 at end of treatment) and concurrent resolution of all 10 MADRS items, all MADRS6 subscale items, and all items

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Cassino, Cara, Anita F. Das, and Joy Lipka. "LB12. Exebacase Shows Rapid Symptom Resolution in a Phase 2 Study in Adult Patients with Staphylococcus aureus bacteremia." Open Forum Infectious Diseases 8, Supplement_1 (2021): S811. http://dx.doi.org/10.1093/ofid/ofab466.1648.

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Abstract Background Exebacase (EXB), a recombinantly-produced lysin (cell wall hydrolase), is the first direct lytic agent to advance into Phase 3 of clinical development for the treatment of bacteremia including infective endocarditis due to Staphylococcus aureus. The microbiologic attributes of EXB, including pathogen-targeted rapid bacteriolysis, and biofilm eradication are distinct from and synergistic with those of traditional antibiotics and underpin the therapeutic potential for EXB. Methods The Phase 2 trial was a randomized, double-blind, placebo-controlled multinational study. Patien

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Krishna, Yamuna T., Kristine L. Griffin, and Robert L. Gates. "Pediatric Biliary Dyskinesia: Evaluating Predictive Factors for Successful Treatment of Biliary Dyskinesia with Laparoscopic Cholecystectomy." American Surgeon 84, no. 9 (2018): 1401–5. http://dx.doi.org/10.1177/000313481808400939.

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Biliary dyskinesia (BD) is a motility disorder of the gallbladder that can result in right upper quadrant (RUQ) pain, nausea, vomiting, and diarrhea. Cholecystectomy is considered the standard of care for BD. Up to 23 per cent of pediatric patients who undergo surgery for BD have persistent symptoms postoperatively. We performed a retrospective review to identify preoperative factors significantly associated with symptom resolution after cholecystectomy. We retrospectively reviewed pediatric patients aged 10–17 years diagnosed with BD who underwent cholecystectomy between 2006 and 2016. Patien

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Daumeyer, Natalie M., Daniel Kreitzberg, Kathleen M. Gavin, and Timothy A. Bauer. "Real-world evidence: Telemedicine for complicated cases of urinary tract infection." PLOS ONE 18, no. 2 (2023): e0280386. http://dx.doi.org/10.1371/journal.pone.0280386.

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Telemedicine programs for the treatment of urinary tract infections (UTIs) offer an opportunity to reduce burdens on patients and providers. However, these programs are typically restricted to patients with uncomplicated UTIs. This real-world analysis evaluated treatment and resolution rates in a large-scale, national UTI telemedicine program inclusive of patients with uncomplicated and complicated UTIs. We conducted a retrospective analysis of data obtained from a commercially available telemedicine program for the treatment of UTIs among adult women in the US between 2017 and 2021 (n = 51,47

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Ilyas, Mohammad, Muhammad Nauman Khan, Rizwan Ullah, Sidra Fayyaz, and Khalid Naseeb. "Symptoms to Balloon time Dependent St-Segment Resolution Post Primary Percutaneous Coronary Intervention and its Impact on Mortality." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 496–99. http://dx.doi.org/10.53350/pjmhs22168496.

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Background: The ST-segment elevation myocardial infarction (STEMI) is an emergency manifestation of coronary artery disease (CAD) that occurs when one epicardial coronary artery is completely blocked. Study aims to test whether symptom-onset-to-balloon time correlates with in-hospital outcomes after primary percutaneous coronary intervention (PPCI) among patients with STEMI. Methodology: under the Hospital Ethical and Research Committee's approval, NICVD's Department of Interventional Cardiology conducted a prospective cohort study that lasted for 6 months. Patients fulfilling the criteria of

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Kai, Yutaka, Jun-ichiro Hamada, Motohiro Morioka, Shigetoshi Yano, and Jun-ichi Kuratsu. "TREATMENT OF CAVERNOUS SINUS DURAL ARTERIOVENOUS FISTULAE BY EXTERNAL MANUAL CAROTID COMPRESSION." Neurosurgery 60, no. 2 (2007): 253–58. http://dx.doi.org/10.1227/01.neu.0000249274.49192.3b.

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Abstract OBJECTIVE External manual carotid compression is a noninvasive method to treat cavernous sinus (CS) dural arteriovenous fistulae (DAVF). We studied a group of patients with CS-DAVF to identify what factors made complete resolution of their clinical symptoms and closure of the DAVF on magnetic resonance angiography (MRA) by compression therapy possible. METHODS We treated 23 patients with CS-DAVF without cortical venous drainage or a recent decline in visual acuity by compression therapy. All were followed up by magnetic resonance angiography at 1, 3, 6, and 12 months after treatment a

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Phillips, Kayleigh, Carli Coalter, Hunter Fly, et al. "Comparison of Short vs. Extended Antibiotic Durations for Patients in the Neonatal Intensive Care Unit with Late Onset, Culture-negative Sepsis." Journal of the Pediatric Infectious Diseases Society 13, Supplement_4 (2024): 12. http://dx.doi.org/10.1093/jpids/piae093.033.

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Abstract Background Culture-proven late-onset sepsis in neonates and preterm infants, defined as symptom onset after 3-7 days of life, is a common cause of morbidity and mortality. Some patients are treated with antibiotics for sepsis despite lack of positive cultures after 48 hours of incubation, potentially due to the non-traditional signs of sepsis. Controversy remains over optimal treatment durations of culture-negative sepsis with durations reported as 2 to 7 days, and rarely longer than 7 days. The primary outcome of this study is to compare lack of symptom resolution at 7 days in patien

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Schreiber, Stefan, Stephen B. Hanauer, William J. Sandborn, and Karen Barrett. "Time to Symptom Resolution in Ulcerative Colitis With Multimatrix Mesalazine Treatment: A Pooled Analysis." Journal of Crohn's and Colitis 14, no. 9 (2020): 1274–81. http://dx.doi.org/10.1093/ecco-jcc/jjaa041.

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Abstract Background and Aims Patients with ulcerative colitis [UC] require rapid and complete relief of symptoms, particularly stool frequency and rectal bleeding. The aim of this study was to determine time to symptom resolution in patients with UC during induction treatment with multimatrix mesalazine, and the proportion of patients remaining symptom-free and in endoscopic remission after 12 months of maintenance. Methods A pooled analysis of 5 pivotal clinical trials, including &gt;1300 patients, evaluating multimatrix mesalazine for treatment of mild-to-moderate active UC was conducted

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Tinoco da Silva Torres, J., J. Panés, C. A. Siegel, et al. "DOP76 Individual and comprehensive symptom resolution after induction and maintenance therapy with risankizumab in patients with moderately to severely active Ulcerative Colitis: A post-hoc analysis of INSPIRE and COMMAND studies." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i214—i215. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0116.

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Abstract Background Short-term treatment goals in ulcerative colitis (UC) are to control inflammation and reduce symptoms, while long-term goals include endoscopic healing, absence of disability and normalisation of quality of life. This post-hoc analysis examined the effect of induction and maintenance treatment with risankizumab (RZB) on UC-related symptoms of abdominal pain (AP), bowel urgency (BU), tenesmus (TN), faecal incontinence (FI), nocturnal bowel movements (NBM), and sleep interruption (SI). Methods Patients (pts) from the INSPIRE induction (NCT03398148) study received intravenous

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Gebeyehu, Endalew, Desalegn Nigatu, and Ephrem Engidawork. "Complete symptom resolution as predictor of Helicobacter pylori eradication and factors affecting symptom resolution: Prospective follow up study." PLOS ONE 16, no. 2 (2021): e0246624. http://dx.doi.org/10.1371/journal.pone.0246624.

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Background Symptom resolution is the most common clinical practice during assessment and evaluation of helicobacter pylori infected patients after employing eradication therapy. Objective Prediction of eradication of H. pylori with symptom resolution and assess factors affecting symptom resolution. Method Facility based follow up study was done on consented H. pylori positive adult patients who received standard triple therapy consisting of a proton pump inhibitor, amoxicillin, and clarithromycin from May 2016 to April 2018 at Bahir Dar city in Ethiopia. Sociodemographic and clinical data was

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Torres, Lisette, Sanah Vohra, Mahlet Mekonnen, et al. "SURG-45. THE EFFECT OF STAPEDECTOMY IN POSTOPERATIVE OUTCOME OF SUPERIOR SEMICIRCULAR CANAL DEHISCENCE: A CASE SERIES OF 349 REPAIRS." Neuro-Oncology 25, Supplement_5 (2023): v272. http://dx.doi.org/10.1093/neuonc/noad179.1043.

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Abstract INTRODUCTION Superior Semicircular Canal Dehiscence (SSCD) is a pathology of the otic capsule, in which, a “third mobile window” is formed on the osseous labyrinth surrounding the superior semicircular canal. Otosclerosis, another otic capsule pathology, can occur concurrently, therefore obscuring the symptoms seen in patients with SSCD. It is currently unknown whether the surgical procedures to treat otosclerosis such as stapedectomy can affect symptom resolution in patients following SSCD repair. Objective: To examine the association between post-SSCD repair symptom resolution and h

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Eckenrode, Amanda H., Joseph A. Ewing, Jennifer Kotrady, Allyson L. Hale, and Dane E. Smith. "HIDA Scan with Ejection Fraction is over Utilized in the Management of Biliary Dyskinesia." American Surgeon 81, no. 7 (2015): 669–73. http://dx.doi.org/10.1177/000313481508100714.

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Patients with upper abdominal pain, nausea, and vomiting are often evaluated with ultrasound to diagnose symptomatic cholelithiasis or cholecystitis. With a normal ultrasound, a hepatobiliary iminodiacetic acid (HIDA) scan with ejection fraction (EF) is recommended to evaluate gallbladder function. The purpose of this study was to evaluate whether the HIDA scan with EF was appropriately utilized in considering cholecystectomy. Over 18 months, we performed 1533 HIDA scans with EF. After exclusion, 1501 were analyzable, 438 of whom underwent laparoscopic cholecystectomy. Patients were divided in

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Srinivas, Melpakkam, and Piyush Bawane. "Does Chicago Classification address Symptom Correlation with High-resolution Esophageal Manometry?" Euroasian Journal of Hepato-Gastroenterology 7, no. 2 (2017): 122–25. http://dx.doi.org/10.5005/jp-journals-10018-1231.

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ABSTRACT Aim To assess the correlation of symptoms with findings on esophageal high-resolution manometry (HRM) in Indian patients. Materials and methods Prospective data collection of all patients undergoing esophageal manometry was done at two centers in India—Indore and Chennai—over a period of 18 months. Symptom profile of the study group was divided into four: Motor dysphagia, noncardiac chest pain (NCCP), gastroesophageal reflux (GER), and esophageal belchers. The symptoms were correlated with manometric findings. Results Of the study group (154), 35.71% patients had a normal study, while

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Virtanen, M., M. J. Shipley, G. D. Batty, et al. "Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study." Psychological Medicine 45, no. 10 (2015): 2137–44. http://dx.doi.org/10.1017/s0033291715000070.

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BackgroundElevated levels of interleukin-6 (IL-6) have been associated with the development of common mental disorders, such as depression, but its role in symptom resolution is unclear.MethodWe examined the association between IL-6 and symptom resolution in a non-clinical sample of participants with psychological distress.ResultsRelative to high IL-6 levels, low levels at baseline were associated with symptom resolution at follow-up [age- and sex-adjusted risk ratio (RR) = 1.15, 95% confidence interval (CI) 1.06–1.25]. Further adjustment for covariates had little effect on the association. Sy

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Virtanen, Marianna, Jane E. Ferrie, Tasnime Akbaraly, et al. "Metabolic Syndrome and Symptom Resolution in Depression." Journal of Clinical Psychiatry 78, no. 01 (2017): e1-e7. http://dx.doi.org/10.4088/jcp.15m10399.

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Catinean, Adrian, Anamaria Sida, Celina Silvestru, and Gheorghe G. Balan. "Ongoing Treatment with a Spore-Based Probiotic Containing Five Strains of Bacillus Improves Outcomes of Mild COVID-19." Nutrients 15, no. 3 (2023): 488. http://dx.doi.org/10.3390/nu15030488.

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Spore-based Bacillus probiotic treatment improves intestinal health. The intestinal microbiota influences both the innate and adaptive immune responses. As such, the influence of ongoing spore-based probiotic treatment (five probiotic strains of Bacillus) on the clinical outcomes of mild COVID-19 was evaluated in this retrospective, observational study. Demographics, medical history, probiotic use, and COVID-19 symptom information were collected. The study included 120 patients with a PCR-confirmed SARS-CoV-2 infection and mild COVID-19 symptoms. The probiotic group (n = 60) comprised patients

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Yamamoto, Y., T. Kawasoe, M. Ibusuki, K. Kai, S. Tomita, and H. Iwase. "Aromatase inhibitor-induced joint symptom in patients with breast cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 11070. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.11070.

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11070 Background: Aromatase inhibitor (AI) are superior to tamoxifen (TAM) for postmenopausal women with estrogen receptor (ER)-positive breast cancer. Toxic profiles are different between AI and TAM. The frequency of bone fracture and joint symptom are high in AI compared with TAM. However, there is little report concerning a detailed joint symptom. Methods: From January 2002 to March 2006, 120 postmenopausal women with ER-positive breast cancer were treated with anastrozole 1mg or exemestane 25mg daily at our hospital. We studied retrospectively the incidence, onset, type, sites, grade, and

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Frommer, Leah J., Kelly K. Gurka, Kevin M. Cross, Christopher D. Ingersoll, R. Dawn Comstock, and Susan A. Saliba. "Sex Differences in Concussion Symptoms of High School Athletes." Journal of Athletic Training 46, no. 1 (2011): 76–84. http://dx.doi.org/10.4085/1062-6050-46.1.76.

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Abstract Context: More than 1.6 million sport-related concussions occur every year in the United States, affecting greater than 5% of all high school athletes who participate in contact sports. As more females participate in sports, understanding possible differences in concussion symptoms between sexes becomes more important. Objective: To compare symptoms, symptom resolution time, and time to return to sport between males and females with sport-related concussions. Design: Descriptive epidemiology study. Setting: Data were collected from 100 high schools via High School RIO (Reporting Inform

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Ozturk, Erin, Catherine Chanfreau-Coffinier, McKenna S. Sakamoto, Victoria C. Merritt, and Lisa Delano-Wood. "A-94 Characterization of Million Veteran Program (MVP) Enrollees with Comprehensive TBI Evaluation (CTBIE) Data: An Analysis of Neurobehavioral Symptoms." Archives of Clinical Neuropsychology 36, no. 6 (2021): 1141. http://dx.doi.org/10.1093/arclin/acab062.112.

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Abstract Objective Using a large sample of U.S. Veterans enrolled in the Million Veteran Program (MVP), we sought to evaluate neurobehavioral symptoms obtained from the Veterans Health Administration’s Comprehensive Traumatic Brain Injury Evaluation (CTBIE). Method Eligible participants (N = 12,144) included MVP-enrolled Veterans who completed the CTBIE, a clinician-administered interview that assesses for historical, deployment-related TBIs and evaluates current symptoms using the Neurobehavioral Symptom Inventory (NSI). Clinicians completing the CTBIE made clinical determinations about each

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R, Banerjee. "Effectiveness of Omeprazole versus Pantoprazole for Symptomatic Relief of Gastro-Esophageal Reflux Disease (GERD)/ Acid Peptic Disease (APD): A Real-World Evidence (RWE) Study." Gastroenterology & Hepatology International Journal 9, no. 2 (2024): 1–15. http://dx.doi.org/10.23880/ghij-16000219.

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Objective: To compare the effectiveness of omeprazole versus pantoprazole for satisfactory resolution of GERD/APD symptoms. Design: This multicentric, real-world evidence (RWE) study was conducted using data extracted from electronic medical records (EMRs) of anonymized, treatment-naïve, adult GERD/APD patients treated with proton pump inhibitors (PPIs) omeprazole or pantoprazole. The primary endpoint was the proportion of patients achieving satisfactory symptom resolution with 20mg/day omeprazole versus 40mg/day pantoprazole after 14(±7) and 28(±7) days. Secondary endpoints included lifestyle

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Jeon, Hye Kyung, Gwang Ha Kim, Moon Won Lee, Dong Chan Joo, and Bong Eun Lee. "Randomized Controlled Trial Comparing the Efficacy of Sustained-Release Formula of Mosapride-Plus-Esomeprazole Combination Therapy to Esomeprazole Monotherapy in Patients with Gastroesophageal Reflux Disease." Journal of Clinical Medicine 11, no. 7 (2022): 1965. http://dx.doi.org/10.3390/jcm11071965.

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We aimed to evaluate whether adding a sustained-release (SR) formula of mosapride to proton-pump inhibitors (PPIs) would be more effective in controlling symptoms than PPI alone in patients with gastroesophageal reflux disease (GERD). Sixty patients with heartburn and/or regurgitation were randomly assigned to two groups: mosapride SR 15 mg combined with esomeprazole 20 mg once daily (ME group) and esomeprazole 20 mg once daily alone (E group). The primary endpoint was the complete-resolution rate of GERD symptoms after eight-week medication, and the secondary endpoints were the complete-resol

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Usmani, Rashad H., Samuel S. Abrams, and Gregory A. Merrell. "Establishing an Efficient Care Paradigm for Trigger Finger." Journal of Hand Surgery (Asian-Pacific Volume) 23, no. 03 (2018): 356–59. http://dx.doi.org/10.1142/s2424835518500364.

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Background: To identify the time course for efficacy of corticosteroid injections in the treatment of trigger finger. Methods: A prospective single-center observational study was conducted, consisting of 38 patients with 41 trigger digits that were injected. Enrolled patients completed an initial Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire to determine the severity of their symptoms. Following the injection, patients were contacted at scheduled time points for up to 12 weeks to determine if, and when, objective resolution of symptoms occurred. Patients who received additio

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Cohrssen, Andreas, Uzma Aslam, Allison Karasz, and Matthew Anderson. "Are unexplained vaginal symptoms associated with psychosocial distress? A pilot investigation." Journal of Primary Health Care 2, no. 2 (2010): 150. http://dx.doi.org/10.1071/hc10150.

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AIM: Vaginal complaints cannot be definitively diagnosed in approximately one-third of women. We sought to determine if women without a diagnosis had higher levels of psychiatric disorders. METHODS: This was an observational study in an urban family practice clinic. Prior to seeing a clinician, women with vaginal complaints completed the Patient Health Questionnaire (PHQ); symptoms were measured by the Vaginal Complaints Scale (VCS). Patients were then examined and treated by a family physician. At one and two weeks time patients were contacted by phone regarding symptom resolution and clinic

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Lamahewa, Kethakie, Marta Buszewicz, Kate Walters, Louise Marston, and Irwin Nazareth. "Persistent unexplained physical symptoms: a prospective longitudinal cohort study in UK primary care." British Journal of General Practice 69, no. 681 (2019): e246-e253. http://dx.doi.org/10.3399/bjgp19x701249.

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BackgroundUnexplained physical symptoms (UPS) are extremely common among primary care attenders, but little is known about their longer-term outcome.AimTo investigate the persistence of somatic symptoms at 6 months among a cohort with multiple UPS, and identify prognostic factors associated with worsening symptom scores.Design and settingProspective longitudinal cohort study involving adults attending UK general practice in North and Central London between January and December 2013.MethodConsecutive adults attending nine general practices were screened to identify those with at least three UPS

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Brennan, Christina M., Sandeep Nadella, Xiang Zhao, et al. "Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial." Gut 71, no. 5 (2022): 879–88. http://dx.doi.org/10.1136/gutjnl-2022-326952.

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ObjectiveWe assessed whether famotidine improved inflammation and symptomatic recovery in outpatients with mild to moderate COVID-19.DesignRandomised, double-blind, placebo-controlled, fully remote, phase 2 clinical trial (NCT04724720) enrolling symptomatic unvaccinated adult outpatients with confirmed COVID-19 between January 2021 and April 2021 from two US centres. Patients self-administered 80 mg famotidine (n=28) or placebo (n=27) orally three times a day for 14 consecutive days. Endpoints were time to (primary) or rate of (secondary) symptom resolution, and resolution of inflammation (exp

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Kindt, Lexy, Charly Vang, Emily Colonna, et al. "995 Amputation and Extremity-Specific Outcomes in Frostbite: A Comparative Longitudinal Study." Journal of Burn Care & Research 46, Supplement_1 (2025): S393—S394. https://doi.org/10.1093/jbcr/iraf019.526.

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Abstract Introduction Severe frostbite injury can lead to significant long-term functional impairments. This study aims to assess long-term function and symptom resolution in upper vs. lower extremity frostbite. We hypothesize that symptom resolution is slower in upper extremity injury and need for functional assistance is higher in lower extremity injury. Methods A longitudinal cohort of 182 severe frostbite injured patients, defined with a post-rewarming perfusion deficit on imaging and/or clinical diagnosis, included 137 patients with isolated upper or lower extremity injury. Analyses were

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Manoj, Kumar, Kumar Sanjeev, Ozair Md., and Kumar Thakur Varun. "A Comparative Study of Amoxicillin and Ampicillin in Acute Infections of the Ear, Nose, and Throat." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1975–78. https://doi.org/10.5281/zenodo.12802626.

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<strong>Background:</strong> Acute infections of the ear, nose, and throat (ENT) are common and can significantly impact patient quality of life. Effective treatment is crucial for symptom resolution and prevention of complications. Amoxicillin and ampicillin, both penicillin-derived antibiotics, are widely used, but their comparative efficacy and safety in acute ENT infections require further evaluation. This study aims to compare the efficacy and safety of amoxicillin and ampicillin in the treatment of acute ENT infections. <strong>Methods:</strong> A total of 62 participants

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Chason, Mattia E., Maureen Monaghan, Jichuan Wang, Yao Cheng, and Roberta L. DeBiasi. "Symptom Resolution in Pediatric Patients With Lyme Disease." Journal of the Pediatric Infectious Diseases Society 8, no. 2 (2018): 170–73. http://dx.doi.org/10.1093/jpids/piy067.

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Howell, David R., Morgan N. Potter, Michael W. Kirkwood, Pamela E. Wilson, Aaron Provance, and Julie C. Wilson. "CLINICAL PREDICTORS OF SYMPTOM RESOLUTION FOR CHILDREN AND ADOLESCENTS WITH SPORT-RELATED CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0000. http://dx.doi.org/10.1177/2325967119s00007.

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Background: Early prognosis of expected recovery duration after a sport-related concussion is a challenging task for sports medicine clinicians, as various pre-morbid, injury characteristic, and functional factors have been identified to help predict recovery. The purpose of this investigation was to determine which variables obtained as a part of a routine concussion clinical evaluation were independently associated with symptom resolution time among pediatric patients evaluated after sport-related concussion by a sports medicine physician. Methods: We conducted an analysis of data collected

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Lizardo, Kaitlyn, Mackenzie Brown, and S. Aaron Ralston. "LAMOTRIGINE OVERDOSE CAUSING SEIZURE AND APNEA WITH RAPID CLINICAL IMPROVEMENT: A CASE REPORT." JOURNAL OF MEDICAL TOXICOLOGY AND CLINICAL CASE REPORTS 01, no. 01 (2024): 01–03. http://dx.doi.org/10.51521/jmtccr.2024.11102.

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overdose on less than a month’s supply of low dose Lamotrigine can result in significant morbidity. In this case report, we detail the instance of a 25-year-old male who overdosed by consuming a 20- day supply of his prescribed lamotrigine, amounting to approximately 4 grams in total. The patient arrived approximately 90 minutes post-ingestion, displaying symptoms of nystagmus and mild fatigue. Within the subsequent two hours, seizures and apnea emerged, necessitating intubation. Effective treatment was administered, and the patient had symptom resolution within 12 hours. The patient’s symptom

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van Boxel, GI, M. Hart, A. Kiszely, and S. Appleton. "Elective day-case laparoscopic cholecystectomy: a formal assessment of the need for outpatient follow-up." Annals of The Royal College of Surgeons of England 95, no. 8 (2013): 561–64. http://dx.doi.org/10.1308/rcsann.2013.95.8.561.

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Introduction Elective laparoscopic cholecystectomy (LC) is performed routinely as day-case surgery. Most hospital trusts have a policy of no routine postoperative outpatient follow-up although there are no formal guidelines on this. The aim of this retrospective study was to identify the incidence of complications, the degree of symptom resolution and patient satisfaction with a view to formally appraising the need for outpatient follow-up. Methods Patients who underwent LC in the period between February 2011 and June 2012 were contacted retrospectively by telephone. A standardised questionnai

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van Boxel, GI, M. Hart, A. Kiszely, and S. Appleton. "Elective day-case laparoscopic cholecystectomy: a formal assessment of the need for outpatient follow-up." Annals of The Royal College of Surgeons of England 95, no. 8 (2013): e10-e14. http://dx.doi.org/10.1308/rcsann.2013.95.8.e10.

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Introduction Elective laparoscopic cholecystectomy (LC) is performed routinely as day-case surgery. Most hospital trusts have a policy of no routine postoperative outpatient follow-up although there are no formal guidelines on this. The aim of this retrospective study was to identify the incidence of complications, the degree of symptom resolution and patient satisfaction with a view to formally appraising the need for outpatient follow-up. Methods Patients who underwent LC in the period between February 2011 and June 2012 were contacted retrospectively by telephone. A standardised questionnai

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Howell, David R., Morgan N. Potter, Michael W. Kirkwood, Pamela E. Wilson, Aaron J. Provance, and Julie C. Wilson. "Clinical predictors of symptom resolution for children and adolescents with sport-related concussion." Journal of Neurosurgery: Pediatrics 24, no. 1 (2019): 54–61. http://dx.doi.org/10.3171/2018.11.peds18626.

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OBJECTIVEThe goal of this study was to determine which variables assessed during an initial clinical evaluation for concussion are independently associated with time until symptom resolution among pediatric patients.METHODSData collected from a prospective clinical registry of pediatric patients with concussion were analyzed. The primary outcome variable was time from injury until symptom resolution. Predictor variables assessed within 10 days after injury included preinjury factors, Health and Behavior Inventory scores, headache severity, and balance, vestibular, and oculomotor test performan

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Jawid, Maryam Y., Kristen L. Williams, Jacob Jo, et al. "Acute psychological symptom profiles in high school athletes following sport-related concussion." Neurosurgical Focus 57, no. 1 (2024): E10. http://dx.doi.org/10.3171/2024.4.focus24160.

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OBJECTIVE Psychological symptoms following a sport-related concussion may affect recovery in adolescent athletes. Therefore, the aims of this study were to 1) describe the proportion of athletes with acute psychological symptoms, 2) identify potential predictors of higher initial psychological symptoms, and 3) determine whether psychological symptoms affect recovery in a cohort of concussed high school athletes. METHODS A retrospective cohort study of high school athletes (14–18 years of age) who sustained a sport-related concussion from November 2017 to April 2022 and presented to a multidisc

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Baker, A., A. Grobler, K. Davies, et al. "O002 Medical therapy for sleep disordered breathing in children: a randomised, double-blind placebo-controlled trial." SLEEP Advances 2, Supplement_1 (2021): A1. http://dx.doi.org/10.1093/sleepadvances/zpab014.001.

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Abstract Background Sleep Disordered Breathing (SDB) in children is characterised by snoring and breathing difficulties during sleep. Small clinical trials suggest intranasal corticosteroids reduce SDB severity as defined by polysomnography. We assessed the efficacy of intranasal corticosteroid for improving symptoms and quality of life (QOL) in children with SDB. Methods This is a double-blind, randomised, placebo-controlled trial of healthy children 3-12y referred to a specialist with SDB symptoms. Exclusions were previous adenotonsillectomy, obesity or severe SDB. Participants received dail

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KHAN, S., A. MUNEEB, and MS AHMAD. "COMPARATIVE EFFICACY OF PROTON PUMP INHIBITORS VS. H2 RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1496. https://doi.org/10.54112/bcsrj.v2024i1.1496.

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Gastroesophageal reflux disease (GERD) is a common condition characterized by acid reflux into the esophagus, leading to symptoms such as heartburn and regurgitation. Objective: To compare the efficacy of Proton Pump Inhibitors (PPIs) and H2 Receptor Antagonists (H2RAs) in treating GERD in a cohort of 800 patients, assessing symptom relief, healing rates, and side effects. Methods: A total of 800 patients diagnosed with GERD were added to receive either PPIs (n=400) or H2RAs (n=400) for a treatment period of 8 weeks. The primary outcome was improved GERD symptoms, measured using a standardized

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Vikas, Kumar. "Pre-procedural MRI Findings in Different Grades of Achilles Tendinitis and Correlated with Clinical Outcomes after Ultrasound-guided Retrocalcaneal Bursa Injections of Steroid." International Journal of Pharmaceutical and Clinical Research 13, no. 6 (2021): 669–75. https://doi.org/10.5281/zenodo.14225449.

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<strong>Aim:</strong> The aim of the study to evaluate the correlation between Clinical Outcome Following Ultrasound guided Steroid Injection in Retrocalcaneal Bursa and Preprocedural MRI Findings in Different Grades of Achilles Tendinitis. <strong>Methods: </strong>This prospective randomized control study conducted in the Department of Physical Medicine and Rehabilitation, Patna Medical College, Patna, Bihar, India, for 3 months. A total of 50 patients participated in this study. Ankle MRI was done with a 1.5-T MRI system. In each case, apart from the usual sagittal and axial

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Wasserman, Erin, Sara Quetant, Melissa Baker, Sarah Morris, and Christy Collins. "Comparison of Symptomology, Symptom Resolution Time, and Return to Play Time between Concussions Sustained in the Same Academic Year." Neurology 93, no. 14 Supplement 1 (2019): S24.1—S24. http://dx.doi.org/10.1212/01.wnl.0000581064.68712.55.

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ObjectiveThe purpose of this study is to examine symptomology, symptom resolution time, and return to play (RTP) time between concussions sustained in the same academic year.BackgroundPrevious research shows that among those with a history of previous concussions, outcomes for a recurrent concussion are worse, especially when concussions occur within two weeks of each other. Despite this research, there has been little investigation into concussions that occur in the same academic year.Design/MethodsConcussion data was collected from the National Collegiate Athletic Association (NCAA) Injury S

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Kratz, Susan Vaughan. "Case report: Manual therapies promote resolution of persistent post-concussion symptoms in a 24-year-old athlete." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2095222. http://dx.doi.org/10.1177/2050313x20952224.

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This case report illustrates the treatment outcomes of a collegiate athlete presenting with an 18-month history of post-concussion syndrome who received a series of mixed manual therapies in isolation of other therapy. Persistent symptoms were self-reported as debilitating, contributing to self-removal from participation in school, work, and leisure activities. Patient and parent interviews captured the history of multiple concussions and other sports-related injuries. Neurological screening and activities of daily living were baseline measured. Post-Concussion Symptom Checklist and Headache I

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Berkner, Justin, William P. Meehan, Christina L. Master, and David R. Howell. "Gait and Quiet-Stance Performance Among Adolescents After Concussion-Symptom Resolution." Journal of Athletic Training 52, no. 12 (2017): 1089–95. http://dx.doi.org/10.4085/1062-6050-52.11.23.

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Context: Concussions affect a large number of US athletes each year. Returning an athlete to activity once self-reported symptoms have resolved can be problematic if unrecognized neurocognitive and balance deficits persist. Pairing cognitive and motor tasks or cognitive and quiet-stance tasks may allow clinicians to detect and monitor these changes postconcussion. Objective: To prospectively examine adolescent athletes' gait and quiet-stance performance while concurrently completing a cognitive task acutely after concussion and after symptom resolution. Design: Case-control study. Setting: Spo

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Wilfong, Lalan S., Amila Patel, Lance Ortega, et al. "Improvement in incident resolution time with implementation of an electronic patient management solution at a community oncology practice." Journal of Clinical Oncology 39, no. 15_suppl (2021): 1578. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1578.

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1578 Background: Value-based care models such as the Oncology Care Model incentivize practices to reduce hospitalizations and emergency department (ED) visits. Texas Oncology found that most ED visits occurred during regular business hours. Prolonged patient call back times were consistently rated poorly on satisfaction surveys and often led to ED visits for symptoms that could be managed in our offices. We partnered with Navigating Cancer (NC) to implement an electronic patient management technology solution. Methods: For each of our 200 locations, call volume was estimated based on clinic vo

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Jeon, Hye Kyung, Gwang Ha Kim, Yong-Il Cheon, Sung-Chan Shin, and Byung Joo Lee. "Efficacy of Tegoprazan in Patients with Laryngopharyngeal Reflux Disease: A Preliminary Feasibility Study." Journal of Clinical Medicine 12, no. 19 (2023): 6116. http://dx.doi.org/10.3390/jcm12196116.

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Tegoprazan is a novel, potent, and highly selective potassium-competitive acid blocker that inhibits gastric acid secretion with rapid onset of action and prolonged control of gastric acidity. We performed a preliminary feasibility study to evaluate whether tegoprazan could control symptoms more effectively than a placebo in patients with laryngopharyngeal reflux disease (LPRD). In this double-blind, randomized, placebo-controlled trial, 35 patients with LPRD were randomly assigned to two groups: tegoprazan 50 mg daily and placebo. The primary endpoint was the complete resolution rate of LPRD

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Resch, Jacob E., Cathleen N. Brown, Stephen N. Macciocchi, C. Munro Cullum, Damond Blueitt, and Michael S. Ferrara. "A Preliminary Formula to Predict Timing of Symptom Resolution for Collegiate Athletes Diagnosed With Sport Concussion." Journal of Athletic Training 50, no. 12 (2015): 1292–98. http://dx.doi.org/10.4085/1062-6050-50.12.03.

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Context Symptom presentation and recovery after sport concussion (SC) are variable. Empirically based models documenting typical symptom duration would assist health care providers in managing return to play after SC. Objective To develop a prediction model for SC symptom duration. Design Cross-sectional study. Setting Two National Collegiate Athletic Association Division I university laboratories. Patients or Other Participants Seventy-six (51 male and 25 female) concussed athletes with an average age of 19.5 ± 1.65 years who were evaluated within 24 hours of diagnosis. Intervention(s) Partic

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