Relevant bibliographies by topics / Synbiotic

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Synbiotic'

Author: Grafiati
Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Synbiotic"

1

Swanson, Kelly S., Glenn R. Gibson, Robert Hutkins, Raylene A. Reimer, Gregor Reid, Kristin Verbeke, Karen P. Scott, et al. "The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics." Nature Reviews Gastroenterology & Hepatology 17, no. 11 (August 21, 2020): 687–701. http://dx.doi.org/10.1038/s41575-020-0344-2.

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Abstract In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.
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Gewaily, Mahmoud S., Safaa E. Abdo, Eman M. Moustafa, Marwa F. AbdEl-kader, Ibrahim M. Abd El-Razek, Mohamed El-Sharnouby, Mohamed Alkafafy, et al. "Dietary Synbiotics Can Help Relieve the Impacts of Deltamethrin Toxicity of Nile Tilapia Reared at Low Temperatures." Animals 11, no. 6 (June 15, 2021): 1790. http://dx.doi.org/10.3390/ani11061790.

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The optimal water temperature for the normal growth of Nile tilapia is between 26 and 28 °C, and the toxicity of pesticides is strongly related to water temperature. An alternate approach to augmenting the resistance of fish to ambient water toxicity and low water temperature via synbiotic feeding was proposed. In this study, fish were allocated into four groups with 10 fish in each replicate, where they were fed a basal diet or synbiotics (550 mg/kg) and kept at a suboptimal water temperature (21 ± 2 °C). The prepared diets were fed to Nile tilapia for 30 days with or without deltamethrin (DMT) ambient exposure (15 μg/L). The groups were named control (basal diet without DMT toxicity), DMT (basal diet with DMT toxicity), synbiotic (synbiotics without DMT toxicity), and DMT + synbiotic (synbiotics with DMT toxicity). The results displayed upregulated transcription of catalase, glutathione peroxidase, and interferon (IFN-γ) genes caused by DMT exposure and synbiotic feeding when compared with the controls. Moreover, HSP70 and CASP3 genes displayed increased transcription caused by DMT exposure without synbiotic feeding. However, fish fed with synbiotics showed downregulated HSP70 and CASP3 gene expressions. The transcription of IL-1β and IL-8 genes were also decreased by DMT exposure, while fish fed synbiotics showed upregulated levels. DMT exposure resulted in irregular histopathological features in gills, intestine, spleen, and liver tissues, while fish fed synbiotics showed regular, normal, and protected histopathological images. Our results indicated that dietary synbiotics ameliorated histopathological damages in DMT-exposed tilapia through alleviation of oxidative stress and inflammation as well as enhancing the immunity.
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Kim, Jina, Hyaekang Kim, Soomin Jeon, Jinchul Jo, Younghoon Kim, and Heebal Kim. "Synergistic Antibacterial Effects of Probiotic Lactic Acid Bacteria with Curcuma longa Rhizome Extract as Synbiotic against Cutibacterium acnes." Applied Sciences 10, no. 24 (December 15, 2020): 8955. http://dx.doi.org/10.3390/app10248955.

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Acne is a chronic inflammatory skin disease induced by Cutibacterium acnes. Recently, the effects of probiotics, prebiotics and synbiotics have been researched for the treatment of skin diseases in humans. However, the synbiotic effect of probiotics and prebiotic Curcuma longa rhizome extract (CLE) on C. acnes remains ambiguous. Therefore, the aim of this study was to investigate the synergistic antibacterial activities of probiotic lactic acid bacteria (LAB) with CLE as a synbiotic against C. acnes. Agar well diffusion assays were performed to determine the inhibitory effects of each combination of one of five Lactobacillus sp. with CLE as synbiotics against C. acnes KCTC 3314. Among them, the comparison between the average diameters of inhibition zones showed that the synbiotic combination of Lactobacillus acidophilus A001F8 and CLE significantly increased the inhibition zone diameters against C. acnes, compared to the use of Lactobacillus acidophilus A001F8 or CLE alone (p < 0.05). In conclusion, the synbiotics of probiotic LAB and CLE showed synergistic antibacterial effects against C. acnes, suggesting therapeutic potential for this synbiotic combination in the development of cosmetics or medicine against C. acnes.
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Villagrán-de la Mora, Zuamí, Karla Nuño, Olga Vázquez-Paulino, Hugo Avalos, Javier Castro-Rosas, Carlos Gómez-Aldapa, Carlos Angulo, Felipe Ascencio, and Angélica Villarruel-López. "Effect of a Synbiotic Mix on Intestinal Structural Changes, and Salmonella Typhimurium and Clostridium Perfringens Colonization in Broiler Chickens." Animals 9, no. 10 (October 10, 2019): 777. http://dx.doi.org/10.3390/ani9100777.

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Synbiotics can prevent gastrointestinal infections in broilers. This work studies the effect of a Synbiotic on broilers. One-day-old male broilers were divided into groups: Control; Synbiotic; Synbiotic + S. Typhimurium; Synbiotic + C. perfringens; Synbiotic + S. Typhimurium + C. perfringens; S. Typhimurium; C. perfringens; and S. Typhimurium + C. perfringens. Histopathological analysis revealed that the Synbiotic promoted longer villi, less deep crypts, and better villi-crypt ratio. Broilers treated with the Synbiotic, infected with pathogens or not, had healthier mucosa. In groups infected with pathogens, the frequency and intensity of histopathologic lesions were lessened often in groups treated with the Synbiotic. The Synbiotic group had higher lactic acid bacteria counts than the Control group on day 39, and the isolation frequency of S. Typhimurium was lower (p < 0.05) in the Synbiotic-treated groups. On day 18, mucosa, villi, villi-crypt ratio, crypt, and feed intake were influenced by Enterobacteriaceae. However, on day 39 (end of the trial), those parameters were influenced by lactic acid bacteria. The Synbiotic influenced morphological modifications in the duodenal mucosa, which in turn gave the broilers the ability to resist infections caused by S. Typhimurium and C. perfringens, by inhibiting their growth and decreasing the intensity and frequency of histopathological injuries.
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Widhani, Alvina, Samsuridjal Djauzi, Franciscus Dhyanagiri Suyatna, and Beti Ernawati Dewi. "Changes in Gut Microbiota and Systemic Inflammation after Synbiotic Supplementation in Patients with Systemic Lupus Erythematosus: A Randomized, Double-Blind, Placebo-Controlled Trial." Cells 11, no. 21 (October 29, 2022): 3419. http://dx.doi.org/10.3390/cells11213419.

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Gut dysbiosis has a role in the pathogenesis of lupus. Synbiotic supplementation may restore the balance of gut microbiota. This study investigated whether synbiotics could improve gut microbiota and systemic inflammation in lupus patients. This randomized, double-blind, placebo-controlled trial was conducted in adult systemic lupus erythematosus (SLE) patients. Subjects were randomized to receive either synbiotics or a placebo. Fecal microbiota, hs-CRP, IL-6, and IL-17 were measured at baseline and after 60 days. Patients who fulfilled the inclusion criteria were randomized into synbiotic (n = 23) and placebo groups (n = 23). In the synbiotic group, hs-CRP was not significantly increased (1.8 [0.9; 4.85] vs. 2.1 [0.9; 4.25] mg/L; pre vs. post; p = 0.23), whereas in the placebo group hs-CRP was increased significantly (1.75 [0.4; 4.45] vs. 3.75 [0.58; 7.05] mg/L; pre vs. post; p = 0.005). In the synbiotic group, IL-6 decreased significantly (8.76 [6.62; 11.39] vs. 6.59 [4.96; 8.01]; pre vs. post; p = 0.02), while there was no significant change in IL-17 level. In the placebo group, there was no significant change in IL-6 and IL-17. Synbiotic supplementation increased the Firmicutes:Bacteroidetes ratio (0.05 ± 0.60 vs. −0.08 ± 0.63, synbiotic vs. placebo p = 0.48) and butyrate metabolism (p = 0.037) and decreased amino sugar and nucleotide sugar metabolism (p = 0.040). There was improvement in the SLE disease activity index 2K (SLEDAI-2K) score in the synbiotic group (14 [9; 16] vs. 8 [2; 12]; pre vs. post; p < 0.001), while no change in the placebo group (9 [8; 18.25] vs. 9 [5.5; 15]; pre vs. post; p = 0.31). Synbiotic supplementation could reduce systemic inflammation and SLE disease activity and alter the composition and functions of gut microbiota.
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Jung, Susie, Kwang-Min Kim, Sung-Min Youn, and Kyu-Nam Kim. "A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effects of Multi-Strain Synbiotic in Patients with Functional Diarrhea and High Fecal Calprotectin Levels: A Pilot Study." Nutrients 14, no. 23 (November 25, 2022): 5017. http://dx.doi.org/10.3390/nu14235017.

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Synbiotics, including probiotics and prebiotics, are useful for patients with functional bowel disorders. However, which synbiotics are beneficial for patients with which diseases, especially those with functional diarrhea (FDr) with high fecal calprotectin levels, is currently unknown. FDr is an extension of irritable bowel syndrome with diarrhea (IBS-D). Although fewer studies have been conducted on FDr compared to IBS-D, its importance is increasing as its prevalence increases. The aim of this study was to evaluate the effects of a synbiotic containing a mixture of Lactobacillus and Bifidobacterium and its substrate, fructooligosaccharide, on bowel symptoms, fecal calprotectin levels, fecal microbiota, and safety in FDr patients with high fecal calprotectin levels. Forty patients were randomly assigned to either a synbiotic group or a placebo group. A total of 20 subjects in the synbiotic group and 19 subjects in the placebo group completed the study (8 weeks). Changes in FDr symptoms, fecal calprotectin levels, and gut microbiota were assessed during the intervention period. At 4 and 8 weeks, the number of bowel movements tended to increase in the synbiotic group, with a significant increase in the number of formed stools rather than loose stools (p < 0.05). Bowel movement satisfaction was significantly increased in the synbiotic group, but not in the placebo group. Intestinal flora analysis revealed that Lactobacillales at the order level was increased only in the synbiotic group at the end of the intervention. In contrast, at week 8 of the intervention, log-transformed fecal calprotectin levels were significantly decreased in the synbiotic group, although the change was not significantly different from that of the placebo group. These findings suggest that the intake of a multi-strain-containing synbiotic for 8 weeks could improve gut symptoms and the intestinal microenvironment of FDr patients with high fecal calprotectin levels.
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Gunawan, Delima Citra Dewi, Mohammad Juffrie, Siti Helmyati Siti Helmyati, and Endang Sutriswati Rahayu. "Synbiotic (L. plantarum Dad-13 and Fructo-oligosaccharide) Powder on Gut Microbiota (L. plantarum, Bifidobacterium and Enterobacteriaceae) on Stunting Children in Yogyakarta, Indonesia." Current Research in Nutrition and Food Science Journal 10, no. 1 (April 29, 2022): 371–83. http://dx.doi.org/10.12944/crnfsj.10.1.31.

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Synbiotics have a positive effect on the composition of the gut microbiota. They will increase the production of short-chain fatty acid that has modulating effect on gastrointestinal epithelial cell integrity, appetite regulation, and immune function. The aim of this study is to determine the effect of synbiotics (L. plantarum Dad-13 and fructo-oligosaccharide) on gut microbiota composition (L. plantarum, Bifidobacterium and Enterobacteriaceae) in stunting children under five in Yogyakarta, Indonesia. The research methods used double blind randomized controlled trials with parallel design. The sample consisted of 39 stunting children under five which was divided into 19 subjects as a synbiotic group given synbiotic (L. plantarum Dad-13 1x1010 CFU and fructo-oligosaccharide 700 mg) powder and 20 subjects as a placebo group given skim milk. The intervention was carried out for 90 days. The result showed that, statistically, there were significant differences in synbiotic group on gut microbiota (increased in L. plantarum and Bifidobacterium, while decreased in Enterobacteriaceae). Protein and carbohydrate were significantly increasing (p=0.000; p=0.001) in synbiotic group compared to placebo group. Body weight and height were significantly different (p=0.000) in both groups. Bodyweight and height of children on synbiotic group was increasing 1.02 and 1.6 times higher than placebo group. Neither morbidity nor weight loss was recorded throughout consumption period. Synbiotic powder has significantly positive effect on gut microbiota that can induce nutrient intake, height and weight gain of stunting children.
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RAI, S., S. MANDAL, R. BEHERA, J. SAHU, T. K. DUTTA, R. JAS, A. CHATTERJEE, D. K. MANDAL, M. KARUNAKARAN, and M. K. GHOSH. "Effect of feeding fermentable synbiotics (Lactobacillus rhamnosus NCDC 298 and fructo-oligosaccharide) to Jersey crossbred calves up to 3 months of age." Indian Journal of Animal Sciences 90, no. 4 (September 1, 2020): 614–17. http://dx.doi.org/10.56093/ijans.v90i4.104215.

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The synbiotic combination of L. rhamnosus NCDC 298 and fructo-oligosaccharide (FOS) is known to be effective against diarrhoea by preventing the adhesion of pathogens to the gutt, hereby, preventing infection and pathology. Such synergistic effect of the combination has emerged as a favourable alternative to antibiotic use against diseases and growth promoters in the livestock industry. The present study assessed the health and growth performance of the calves supplemented fermentable synbiotic fortified milk from 4 to 90 days and observed its performance till 120th day of age. Body temperature and passive immunity (IgG) were significantly better in calves fed synbiotics with notable increase in body weight and heart girth post synbiotic feeding period. These calves had increased dry matter intake per animal/day when compared to the control animals. The populations of Lactobacillus sp. elevated with decreased pathogenic bacteria (Coliform) in faeces on feeding synbiotics and it continued even after 90 days of age indicating colonization of beneficial bacteria. Therefore, feeding of fermentable synbiotics had observable beneficial effects on health, immunity and growth of the Jersey crossbred calves. The findings encourage further verification of fermentable synbiotics fortified milk as a potential growth promoter to young dairy calves.
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Frece, Jadranka, Blaženka Kos, Ivan Krešimir Svetec, Zoran Zgaga, Jasna Beganović, Andreja Leboš, and Jagoda Šušković. "Synbiotic effect of Lactobacillus helveticus M92 and prebiotics on the intestinal microflora and immune system of mice." Journal of Dairy Research 76, no. 1 (January 5, 2009): 98–104. http://dx.doi.org/10.1017/s0022029908003737.

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The synbiotic effect of the oral treatment of Swiss albino mice with milk-based diets supplemented with Lactobacillus helveticus M92 and various kinds of prebiotics was investigated. Survival, competition, adhesion and colonization, as well as, immunomodulating capability of Lb. helveticus M92, in synbiotic combination, in the gastrointestinal tract (GIT) of mice, were monitored. After the mice were fed with synbiotics, the lactic acid bacteria (LAB) counts in faeces were increased and reduction of enterobacteria and sulphite-reducing clostridia was observed. Similar results were obtained in homogenates of small and large intestine of mice on the 1st and 14th day, after feeding with synbiotics. After the mice were orally given viable Lb. helveticus M92 cells, alone or in combination with prebiotic, the concentration of faecal SIgA and total serum IgA antibodies from all immunized mice were higher compared with the control. The specific humoral immune response was not evoked after oral administration, therefore their synbiotic application is suitable. Among inulin, lactulose and raffinose, Lb. helveticus M92 in combination with inulin, has shown the best synbiotic effect on intestinal and faecal microflora and immune system of mice.
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Kahbazi, Manijeh, Marzieh Ebrahimi, Nader Zarinfar, Mohammad Arjomandzadegan, Taha Fereydouni, Fatemeh Karimi, and Amir Reza Najmi. "Efficacy of Synbiotics for Treatment of Bacillary Dysentery in Children: A Double-Blind, Randomized, Placebo-Controlled Study." Advances in Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/3194010.

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Bacillary dysentery is a major cause of children’s admission to hospitals. To assess the probiotic and prebiotic (synbiotics) effects in children with dysentery in a randomized clinical trial, 200 children with dysentery were studied in 2 groups: the synbiotic group received 1 tablet/day of synbiotic for 3–5 days and the placebo group received placebo tablets (identical tablet form like probiotics). The standard treatment was administered for all patients. Duration of hospitalization, dysentery, fever, and the weight loss were assessed in each group. It was concluded that there was no significant difference in both groups in the baseline characteristics. The mean duration of dysentery reduced (P<0.05). The mean duration of fever has been significantly reduced in the synbiotic group (1.64±0.87days) in comparison to the placebo group (2.13±0.94days) (P<0.001). Average amount of weight loss was significantly lower in the synbiotic group in comparison to that in the placebo group (129.5±23.388grams and278±28.385grams, resp.;P<0.001). There was no significant difference in the mean duration of hospitalization in both groups (P>0.05). The use of synbiotics as an adjuvant therapy to the standard treatment of dysentery significantly reduces the duration of dysentery, fever, and rate of weight losses. The trial is registered withIRCT201109267647N1.
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Dissertations / Theses on the topic "Synbiotic"

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Drakoularakou, Alexandra. "Synbiotic studies on selected probiotic bacteria." Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493809.

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One important development which has recently started to be incorporated to the group of functional foods, is that of the synbiotics (combination of probiotics with prebiotics). This study focused on the development of synbiotic versions of three potential probiotic strains (Lactobacillus acidophilus 74-2, Lactobacillus casei 163 and Bifidobacterium lactis 420) with potential prebiotics and their antipathogenic effects were also investigated. The probiotic characteristics of each of the three strains were assessed prior to investigation of potential synbiotic combinations.
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Tzortzis, George. "Development of a novel synbiotic targeted towards dogs." Thesis, University of Reading, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270842.

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Falke, Sarah. "Development of a synbiotic drinkable yogurt for school-aged children." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/35230.

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Master of Science
Food Science Institute
Fadi M. Aramouni
Fermented dairy products have long been associated with positive health benefits. Certain probiotics, such as Lactobacillus rhamnosus, have gained popularity as a natural way to improve health and immunity. Fermented dairy products are an easy way to incorporate and deliver probiotics to the consumer. Synbiotic systems are also being investigated as a method for promoting the growth and survival of probiotic bacteria, both during fermentation and after consumption. The purpose of this research was to develop a synbiotic yogurt drink, incorporating L. rhamnosus (probiotic) and inulin (prebiotic), and to investigate the effect of the synbiotic relationship on sensory, physical, chemical, and microbiological properties over time. Yogurt drinks containing the probiotic L. rhamnosus HN001 (treatment P), inulin (treatment I), and a synbiotic system (treatment S) were tested using a randomized block design. Color, viscosity, brix, syneresis, and pH were measured throughout a shelf-life of 28 days. Consumer acceptability was also tested with middle-school aged children. A shelf-life of 28 days at refrigerated temperature was found to be acceptable for the product based on chemical, physical, and microbial analysis. Based on sensory results, the synbiotic drink was found to be acceptable to the target consumers (scoring a 6.82 in “overall liking” on a 9-point hedonic scale), though the treatment with 3% inulin scored slightly higher in most categories (scoring a 7.24 in “overall liking” on a 9-point hedonic scale).
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Nyanzi, R., PJ Jooste, JO Abu, and EM Beukes. "Consumer acceptability of a synbiotic version of the maize beverage mageu." Development Bank of Southern Africa, 2010. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001193.

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This study examined the possibility of converting mageu, a fermented maize beverage popular throughout southern Africa, into a health-promoting and affordable alternative to probiotic dairy products. A range of probiotic Lactobacillus species was compared with a control species traditionally used to prepare mageu. Prebiotic oligosaccharide (soluble fibre), which enhances the growth of beneficial bacteria, was also included. The resulting beverages were compared in two ways: sensory attributes were determined by a trained panel using quantitative descriptive analysis (QDA), and consumer acceptability was assessed by 53 untrained volunteers. The QDA results suggest that mageu fermented by Lb. acidophilus or Lb. rhamnosus was most similar to the control mageu, while Lb. paracasei mageu and Lb. casei mageu were least similar. The consumer acceptability data confirmed that Lb. acidophilus or Lb. rhamnosus mageu did not differ significantly from the control, suggesting that either of these is suitable for commercial production of probiotic mageu.
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Rodriguez, Agustina. "Evaluation of the synbiotic strategy as prevention and treatment of swine digestive pathologies." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669561.

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L'objectiu d'aquesta Tesi va ser avaluar l'eficàcia de compostos simbiòtics per a millorar la salut i productivitat del bestiar porcí després del deslletament i la seva capacitat per a enfrontar patògens digestius. Per a complir-ho, es van realitzar quatre proves experimentals. En les proves 1 i 2, es van avaluar els efectes d'un simbiòtic format per Bifidobacterium longum subsp. infantis CECT 7210 i inulina enriquida amb oligofructosa en porcs desafiats o no amb Salmonel·la Typhimurium o E. coli enterotoxigènic (ETEC) F4, respectivament. La prova 3 va valorar l'eficàcia d'un probiòtic multisoca compost per la soca anterior i Lactobacillus rhamnosus HN001, barrejats o no amb inulina enriquida amb oligofructosa front a Salmonel·la Typhimurium. La prova 4 va avaluar el mateix probiòtic, administrat o no amb galacto-oligosacàrids en garrins desafiats amb ETEC F4. En les proves 1 i 2 es va seguir un disseny factorial 2x2; tractats o no amb el simbiòtic i desafiats o no amb el patogen. En les proves 3 i 4 es va usar un disseny totalment aleatoritzat constant de cinc grups: un no desafiat (CTR+) i quatre desafiats: la mateixa dieta (CTR-), suplementada amb el probiòtic (PRO), el prebiòtic (PRE) o la combinació dels dos (SYN). Després d'una setmana d'adaptació, els animals van ser desafiats oralment i es va eutanasiar un per corral els dies 4 i 8 (prova 2: 3 i 7) postinfecció. Les principals variables avaluades van ser productivitat, signes clínics, excreció de patogen, perfil fermentatiu, resposta immunitària i morfologia intestinal. El simbiòtic format per Bifidobacterium longum subsp. infantis CECT 7210 i inulina enriquida amb oligofructosa va reduir el número de enterobacteris enganxats i va augmentar la presència de limfòcits intraepitelials en ili de garrins sans. Enfront d'un desafiament, aquest simbiòtic no va poder contrarestar la càrrega de patogen en animals desafiats amb ETEC F4 (prova 2); no obstant, va tendir a accelerar l'eliminació de Salmonel·la (trial 1). Curiosament, en ambdues proves (proves 1 i 2), el simbiòtic va tenir un impacte significatiu en la fermentació colònica, però amb efectes diferents en funció de si els animals havien estat o no desafiats. En la prova 3, la combinació de Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus HN001 i inulina enriquida amb oligofructosa no va mostrar cap impacte en garrins una setmana després del deslletament. Posteriorment al desafiament, el probiòtic va promoure una eliminació fecal accelerada de Salmonel·la i va millorar la recuperació de l'alteració intestinal. El prebiòtic va portar associat un major nombre de limfòcits intraepitelials. La combinació simbiòtica no va mostrar cap activitat sinèrgica enfront del patogen, perdent la majoria dels efectes esmentats. El simbiòtic avaluat en la prova 4, format per Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus HN001 i galacto-oligosacàrids, va reduir el número de enterobacteris i coliforms fecals una setmana després del deslletament, en comparació a PRE i PRO. No obstant, després del desafiament amb ETEC F4, el tractament SYN es va associar amb una major càrrega de ETEC F4 en contingut de còlon. Així mateix, les concentracions elevades de TNF-F-α i Pig-MAP van suggerir la presència d'un estat pro-inflamatori sobreestimulat. Per tant, aquesta combinació no va ser capaç de demostrar cap benefici sinèrgic enfront del patogen, perdent alguns dels efectes observats per al probiòtic o el prebiòtic. Els resultats d'aquesta Tesi assenyalen que la combinació de probiòtics i prebiòtics no necessàriament té un efecte additiu o sinèrgic. El seu impacte en la microbiota intestinal i la resposta de l'individu depenen dels desafiaments als quals els animals han d'enfrontar-se. Són necessaris més estudis per a entendre les complexes interaccions que es produeixen en el tracte gastrointestinal i els mecanismes implicats.
El objetivo de esta Tesis fue evaluar la eficacia de compuestos simbióticos para mejorar la salud y productividad del ganado porcino después del destete y su capacidad para enfrentar patógenos digestivos. Para cumplirlo, se realizaron cuatro pruebas experimentales. En las pruebas 1 y 2, se evaluaron los efectos de un simbiótico formado por Bifidobacterium longum subsp. infantis CECT 7210 e inulina enriquecida con oligofructosa en cerdos desafiados o no con Salmonella Typhimurium o E. coli enterotoxigénica (ETEC) F4, respectivamente. La prueba 3 valoró la eficacia de un probiótico multicepa compuesto por la cepa anterior y Lactobacillus rhamnosus HN001, mezclados o no con inulina enriquecida con oligofructosa frente a Salmonella Typhimurium. La prueba 4 evaluó el mismo probiótico multicepa, administrado o no conjuntamente con galacto-oligosacáridos en lechones desafiados con ETEC F4. En las pruebas 1 y 2 se siguió un diseño factorial 2x2; tratados o no con el simbiótico y desafiados o no con el patógeno. En las pruebas 3 y 4 se usó un diseño totalmente aleatorizado constante de cinco grupos: uno no desafiado (CTR+) y cuatro desafiados: la misma dieta (CTR-), suplementada con el probiótico (PRO), el prebiótico (PRE) o la combinación de ambos (SYN). Después de una semana de adaptación, los animales fueron desafiados oralmente y se eutanasió uno por corral los días 4 y 8 (prueba 2: 3 y 7) posinfección. Las principales variables evaluadas fueron productividad, signos clínicos, excreción de patógeno, perfil fermentativo, respuesta inmunitaria y morfología intestinal. La combinación simbiótica formada por Bifidobacterium longum subsp. infantis CECT 7210 e inulina enriquecida con oligofructosa redujo el número de enterobacterias enganchadas y aumentó la presencia de linfocitos intraepiteliales en íleon de lechones sanos. Frente a un desafío, el simbiótico no pudo contrarrestar la carga de patógeno en animales desafiados con ETEC F4 (prueba 2); sin embargo, tendió a acelerar la eliminación de Salmonella (trial 1). Curiosamente, en ambas pruebas (pruebas 1 y 2), el simbiótico tuvo un impacto significativo en la fermentación colónica, pero con efectos diferentes en función de si los animales habían sido o no desafiados. En la prueba 3, la combinación de Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus HN001 e inulina enriquecida con oligofructosa no mostró ningún impacto en lechones una semana después del destete. Posteriormente al desafío oral, el probiótico promovió una eliminación fecal acelerada de Salmonella y mejoró la recuperación del daño intestinal. El prebiótico trajo asociado un mayor número de linfocitos intrapiteliales. La combinación simbiótica no mostró ninguna actividad sinérgica frente al patógeno, perdiendo la mayoría de los efectos mencionados. El simbiótico evaluado en la prueba 4, formado por Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus HN001 y galacto-oligosacáridos, redujo el número de enterobacterias y coliformes fecales una semana después del destete de los animales, en comparación a PRE y PRO. No obstante, tras el desafío con ETEC F4, el tratamiento SYN se asoció con una mayor carga de ETEC F4 en contenido de colon. Asimismo, las concentraciones elevadas de TNF-α; y Pig-MAP sugirieron la presencia de un estado proinflamatorio sobreestimulado. Por lo tanto, esta combinación no fue capaz de demostrar ningún beneficio sinérgico frente al patógeno, perdiendo algunos de los efectos observados para el probiótico o el prebiótico. Los resultados de esta Tesis señalan que la combinación de probióticos y prebióticos no necesariamente tiene un efecto aditivo o sinérgico. Su impacto en la microbiota intestinal y la respuesta del individuo dependen de los desafíos a los que los animales deben enfrentarse. Son necesarios más estudios para entender las complejas interacciones que se producen en el tracto gastrointestinal y los mecanismos implicados en ellas.
The main objective of this Thesis was to evaluate the efficacy of different synbiotics to improve health and performance of pigs after weaning, as well as their capacity to fight digestive pathogens. To accomplish it, four experimental trials were performed. In trial 1 and trial 2, the effects of a synbiotic composed by Bifidobacterium longum subsp. infantis CECT 7210 and oligofructose-enriched inulin in pigs challenged or not with Salmonella Typhimurium or enterotoxigenic E. coli F4 (ETEC F4), respectively, were evaluated. Trial 3 assessed the efficacy of a multistrain probiotic composed by the former strain and Lactobacillus rhamnosus HN001, mixed or not with oligofructose-enriched inulin against Salmonella Typhimurium. Lastly, trial 4 evaluated the response of the same multistrain probiotic administered or not with galacto-oligosaccharides in weaned piglets challenged with ETEC F4. A 2x2 factorial design was followed for trials 1 and 2; treated or not with the synbiotic and challenged or not with the pathogen; and, for trials 3 and 4, a completely randomized one, composed by five treatment groups: one non-challenged (CTR+) and four challenged: same diet (CTR-), or supplemented with the probiotic (PRO), prebiotic (PRE) or their combination (SYN). After one week of adaptation, animals were orally challenged and one animal per pen was euthanized at day 4 and 8 (3 and 7 for trial 2) post-inoculation. Main variables assessed were animal performance, clinical signs, pathogen excretion, fermentation profile, immune response and intestinal morphology. The synbiotic combination consisting of Bifidobacterium longum subsp. infantis CECT 7210 and oligofructose-enriched inulin reduced the numbers of ileal attached enterobacteria (trial 2) and enhanced the presence of ileal intraepithelial lymphocytes of healthy weaned pigs. In a challenge, the synbiotic mixture could not counteract pathogen loads in animals challenged with ETEC F4 (trial 2); however, it tended to accelerate Salmonella clearance when it was tested against this pathogen (trial 1). Interestingly, in both trials (trial 1 and trial 2), the synbiotic had a significant impact on the colonic fermentation but with differential effects depending on if animals had been or not challenged. In trial 3, the combination of Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus HN001 and oligofructose-enriched inulin did not show to have any significant impact in pigs one week after weaning. After the oral challenge, the multistrain probiotic promoted a faster faecal clearance of Salmonella and improved recovery of intestinal damage. Prebiotic treatment increased number of ileal intraepithelial lymphocytes (IEL). The synbiotic combination did not reflect any synergistic activity against the pathogen, losing most of the previous mentioned effects. The synbiotic evaluated in trial 4, composed by Bifidobacterium longum subsp. infantis CECT 7210, Lactobacillus rhamnosus and galacto-oligosaccharides, decreased the number of faecal enterobacteria and coliforms one week after weaning compared to PRE or PRO. Nevertheless, after the ETEC F4 challenge, SYN treatment was associated to the greatest loads of ETEC F4 in colonic digesta. In addition, an enhanced pro-inflammatory status was suggested by the increased serum concentrations of TNF-α and Pig-MAP. This combination was not able, therefore, to demonstrate any synergistic benefits against the pathogen, losing some of the effects found for the probiotic blend or the prebiotic independently. The results exposed in this Thesis highlight that the combination of probiotics and prebiotics not necessarily result in an additive or synergistic effect. Their impact on the intestinal microbiota and the response of the individual probably depend on the challenges that the animals need to face. More studies are needed to understand the complex interactions roduced in the gastrointestinal tract and the involved mechanisms.
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Pistoli, Stella. "Characterisation of the microflora in Irritable Bowel Syndrome and development of synbiotic treatment." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485399.

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Irritable bowel syndrome (IBS) is a condition where abdominal pain, diarrhoea, constipation, gas distension and/or variability in the bowel habit are experienced. It has been suggested that the gut microflora may be involved in this condition and that an 'abnormal' colonic fermentation may provoke the symptoms ofIBS. In this study, the faecal flora of 11. IBS patients was compared with that of 11 healthy individuals quantitatively using fluorescence in situ hylJridisation (FISH) and· traditional plating techniques, as well as qualitatively using denaturating gradient gel electrophoresis (DGGE). It was found that IBS patients had lower total . . ./ bacterial counts, bifidobacteria, lactobacilli, bacteroides and clostridia than seen in healthy individuals. DGGE also showed differences between illS and healthy samples, especially in relation to stability ofthe microflora over time. A synbiotic version ofLactobacillus plantarum NCIMB 41114 with seven different prebiotics was tested in batch culture fermenters using faecal samples from IBS donors. From all the combinations GOS-synbiotic was chosen sirc~ it enhanced the . . growth of the probiotic and was found to be more effective in 'normalising' the . .~ faecal flora in IBS. This synbiotic combination was used in gut model· systems using faecal samples from donors belonging to different IDS subgroups. The results showed that administration of the synbiotic impacted the specific IBS subgroups .. differently, but modulated the rnicroflora towards selective stimulation of bifidobacteria and lactobacilli. In the last part of the study the amount of gas produced from IBS faecal flora during fermentation was compared to that ofhealthy faecal flora. The IDS flora produced more cumulative gas and had greater rates of production than the healthy flora. Administration of the synbiotic reduced gas production in all systems (IBS and healthy). Taken together, these observations help to define dietary management strategies, based on the gut flora and its activities, aimed towards improving IBS symptomology.
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Fricke, Palmell Jaqueline. "Long-term effects of a synbiotic intervention in ADHD-patients : 18-month follow-up." Thesis, Linnéuniversitetet, Institutionen för psykologi (PSY), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-95367.

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A link between the gut and the brain has been proposed to influence psychiatric disorders. Probiotics have been suggested to modify the gut microbiota and thereby improve autism symptoms in children. Attention deficit hyperactivity disorder (ADHD) has high comorbidity with other neuropsychiatric diagnoses, including autism. This is a follow-up of the first study examining a synbiotic intervention in patients with ADHD (Skott et al., 2019). In the original study, 114 adults participated. In this study, 38 adults were evaluated. The aim was to examine if suggested improvements remained 18 months post treatment. Specifically, if reductions were detected in comorbid autism symptoms, emotional dysregulation or functional impairment. The endpoints were measured using questionnaires: Autism-Spectrum Quotient (AQ), Difficulties in Emotion Regulation Scale (DERS-16) and Weiss Functional Impairment Rating Scale (WFIRS). No Synbiotic2000-specific effect was detected. Synbiotic2000 and placebo improved emotion regulation and life skill-functioning equally well. More research is needed to draw reliable conclusions.
En koppling mellan magen och hjärnan har i studier antytts påverka psykiatriska tillstånd. Probiotika har föreslagits förändra mag- och tarmkanalens bakterieflora och därigenom förbättra psykiatriska symtom hos barn med autism. ADHD har hög komorbiditet med andra neuropsykiatriska diagnoser, däribland autism. Detta är en långtidsuppföljning av RCT-studien som var först med att undersöka en synbiotika-intervention hos patienter med ADHD (Skott et al., 2019). I uppföljningen undersöktes 38 av de 114 vuxna som deltagit i originalstudien. Syftet var att undersöka om indikationerna till förbättring höll i sig 18 månader efter studieavslutet. Frågeställningen var om reduktion i komorbida autismsymtom, svårigheter med emotionsreglering eller funktionsnedsättning kunde identifieras. Detta undersöktes genom självskattningsskalor: Autism-Spectrum Quotient (AQ), Difficulties in Emotion Regulation Scale (DERS-16) och Weiss Functional Impairment Rating Scale (WFIRS). Ingen behandlingsspecifik effekt detekterades. Förbättringar av samma grad identifierades av Synbiotic2000 och placebo, utifrån emotionsreglering samt delskalan färdigheter. Mer forskning på området krävs för att möjliggöra tillförlitliga slutsatser.
BAMBA (Behandla Adhd med MagBakterier)
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Vasylyshyn, Kh I., Ігор Юрійович Висоцький, Игорь Юрьевич Высоцкий, Ihor Yuriiovych Vysotskyi, U. Amaso-Kalu, and Idighri F. Omogheme. "Effect of synbiotic therapy on cytokines concentrations in pre-preschool children with community-acquired pneumonia." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45056.

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The diseases of the respiratory system occupy the first position which constitutes nearly 62-65 % in the structure of child morbidity. Community-acquired pneumonia (CAP) is one of the most common diseases of modern society. Cytokines play a central role in inflammatory response that is a basis for further immune response. Our aim was to study the effect of synbiotics on pro- and anti-inflammatory serum cytokines (IL-8 and IL-4) concentrations in pre-preschool children with CAP.
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Neto, João Valentini. "Efeito da suplementação de simbióticos sobre a inflamação sistêmica de idosos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/89/89131/tde-15052015-113025/.

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Introdução:O envelhecimento está associado a redução na capacidade de lidar/enfrentar estressores, o que significa o principal conceito de fragilidade. Algumas mudanças na composição e função corporal são relacionadas com o desenvolvimento da fragilidade, como: deposição de gordura visceral (altamente relacionada com a inflamação sistêmica) e a redução da gordura subcutânea. Uma alteração importante é a relacionada com um aumento na concentração de marcadores inflamatórios no sangue, o que tem sido associado com um processo mais amplo, denominado inflammaging. Nosso trabalho destaca a hipótese de que esta inflamação de baixo nível é associada a um desbalanço na microbiota e alterações na permeabiliade intestinal, o que então justifica o uso de substâncias simbióticas. Objetivos: avaliar o efeito de uma suplementação por seis meses com substância simbiótica sobre a inflamação sistêmica de idosos em risco de fragilidade. Métodos: foram estudados 49 indivíduos, entre 65-90 anos, que atenderam um ou dois critérios de fragilidade propostos por Fried et al (2001). Tratou-se de um estudo duplo-cego randomizado, no qual os participantes foram alocados em um dos grupos que seguem: SIM (tratamento com simbiótico) - ingestão de uma substância simbiótica (Frutooligossacarideos 6 g, Lactobacillus paracasei 109 a 108 CFU, Lactobacillus rhamnosus 109 a 108 CFU, Lactobacillus acidophilus 109 a 108 CFU e Bifidobacterium lactis 109 a 108 CFU); ou PLA (placebo, controle)- maltodextrina (6g) nas mesmas doses do grupo simbiótico. Ambos os grupos foram instruídos a consumir as substâncias duas vezes ao dia. Antes e após a suplementação os sujeitos foram avaliados para: marcadores plasmáticos de inflamação (IL-6, IL-10 e TNF-α); contagem de células sanguíneas; medidas antropométricas; função intestinal (Escala de Bristol e Critério de ROMAIII). Os dados foram analisados por ANOVA de medidas repetidas (marcadores inflamatórios), com test pos-hoc apropriado, teste T de student (células sanguíneas), bem como odds ratio e redução de risco. Foi adotado o princípio da intenção de tratar. A significância foi considerada para p<0.05. Resultados: O grupo SIM foi composto por 25 sujeitos com idade media de 76.2±8.4 anos, e o grupo PLA foi formado por 24 sujeitos média de idade de 75.6±8.1 anos. A função intestinal melhorou em 5,3% no grupo SIM. Em constraste, o grupo PLA apresentou piora de 20% dos sintomas negativos da função intestinal. O OR da melhora do SIM de acordo com o ROMA III foi de 0.76 (IC= 0.09-6.17), indicando um benefício da suplementação com simbióticos. Os marcadores inflamatórios foram analisados de duas diferentes maneiras: o grupo todo e considerando a idade como co-variável. Quando comparados os grupos, algumas diferenças foram encontradas em função do tempo para ambos os grupos entre os níveis de IL-10 antes (a) e depois (d) da suplementação (p<0,01) (PLAa=3,9±5,4; PLAd=1,4±1,7; SIMa1,9±3,2; SIMd=1,5±1,3) e IL-6 (p<0,01) (PLAa=3,9±5,4; PLAb=2,4±1,6 e SIMa=3,0±1,9; SIMb=2,5±1,1). A contagem de células sanguíneas revelou maior número de basófilos (contagem relativa) (p=0,01) (PLA=4,22±17,91; SIM=32,05±39,85) e monócitos (contagem absoluta) (p=0,04) (PLA=14,58±8,60; SIM=11,00±7,36) no grupo SIM comparado ao grupo PLA. Conclusão: Considerando tudo o que foi exposto, é possível concluir que a suplementação com simbióticos pareceu ser eficiente para idosos considerados em risco de fragilidade, mas ainda é necessário que mais estudos sejam desenvolvidos incluindo populações maiores, e análises de permeabilidade intestinal.
Background: Ageing is associated to a reduction in the capacity to cope with stressors, which is the main concept of frailty. A number of changes in body composition and function are related to the development of frailty, such as: visceral deposition of fat (highly associated with systemic inflammation) and reduction in the subcutaneous fat. A remarkable change is related to a systemic and low level rise in inflammatory markers in the blood, which has been associated to a broader process called inflammaging. Our work highlights the hypothesis that this low-level inflammation is associated to an imbalance in gut microbiota and changes in intestinal permeability, which in turn justifies the use of synbiotic substances. Aims: to evaluate the effect of a 6-month supplementation of a synbiotic substance on the systemic inflammation in elderly in risk of frailty. Methods: we studied 49 individuals, 65-90 years old, fulfilling from one to two frailty criteria proposed by Fried et al (2001). A double-blind randomized clinical trial was performed, in which the participants were allocated in one of the following groups: SYN (symbiotic treatment) - intake of a synbiotic substance (Frutooligossacarideos 6 g, Lactobacillus paracasei 109 to 108 CFU, Lactobacillus rhamnosus 109 to 108 CFU, Lactobacillus acidophilus 109 to 108 CFU and Bifidobacterium lactis 109 to 108 CFU); or PLA (placebo, control)- maltodextrin in the same doses as the SYN group. Both groups were instructed to consume the substances twice a day, for the period of 6 months. Before and after the supplementation the subjects were evaluated for: plasma inflammatory markers (IL-6, IL-10 and TNF-α); blood cells count; anthropometric measures, gut function (Bristol Scale and Roma criteria). Data were analyzed by repeated measures ANOVA (inflammatory markers), with appropriated pos-hoc test, student\'s t Test (blood cells), as well as odds ratio and risk reduction analysis. The Intention to treat principle was adopted. Significance was considered as p<0.05. Results: The PLA group was composed by 24 subjects with mean age of 76.2±8.4 years, and the PLA group was formed by 24 subjects with mean age 75.6±8.1 years. The gut function was improved in 5.3% of SYN. In turn, PLA group presented 20% of negative symptoms of gut function. The OR of improvement of SYN according to ROMA III was 0.76 (CI= 0.09-6.17), indicating a benefit of the synbiotic supplementation. The inflammatory markers were analyzed in two different ways: the whole group and considering the age as co-variable. When compared the whole groups, some differences were found by the time between both groups for IL-10 at baseline (b) and after supplementation (a) for IL-10 (p<0,01) (PLAb=3,9±5,4; PLAa=1,4±1,7; and SYNb1,9±3,2; SYNa=1,5±1,3) and IL6 (p<0,01) (PLAb=3,9±5,4; PLAa=2,4±1,6 and SYNb=3,0±1,9; SYNa=2,5±1,1). The blood cells count revealed higher numbers of basophiles (p=0,01; PLA=4,22±17,91; SYN=32,05±39,85) and monocytes (p=0,04; PLA=14,58±8,60; SYN=11,00±7,36) on the SIM group compared to the PLA group. Conclusion: Taking altogether, it\'s possible to conclude that the synbiotic supplementation seemed to be efficient for the elderly considered in risk of frailty, but it remains necessary to perform more studies, including larger populations and with analysis of gut permeability.
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10

Santos, Douglas Xavier dos. "Synbiotic aerated dessert: diet product development and evaluation of the intake effects in individuals with metabolic syndrome." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9133/tde-22012018-101115/.

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Abstract:
The objective of this work was to adapt a synbiotic aerated diet dessert, produced with the addition of a probiotic culture of Lactobacillus acidophilus La-5 and prebiotic ingredients (fructooligosaccharides and inulin), from the previously developed sucrose-containing formulation, and to evaluate the effects of its ingestion on adult volunteers with metabolic syndrome (MetS) during a period of 8 weeks of intervention. In addition, to improve the resistance of the probiotic to simulated gastrointestinal conditions, a microencapsulation process was optimized. For the development of the product, the formulations were produced in triplicates, in which probiotic culture survival, instrumental texture and sensory acceptability were evaluated up to 112 days of storage under freezing (-18 °C). Subsequently, a randomized, double-blind, placebo-controlled trial was carried out in which the product developed was administered to forty-five volunteers with MetS assigned into two groups, each receiving 40 g/day of: synbiotic diet mousse (SDM) (n=23) and placebo diet mousse (PDM) without pro- and prebiotics (n=22). Fasting blood samples were collected at the beginning and after 8 weeks of daily consumption of both mousses to determine the anthropometric, biochemical, haematological, inflammatory, and immunological parameters. Afterward, with the goal of improving the survival of L. acidophilus La-5 to in vitro simulated gastrointestinal conditions, the microencapsulation process conditions of the probiotic strain via spray drying were optimized using inulin as the encapsulating agent. The viability of L. acidophilus La-5 incorporated into SDM was above 7.8 log CFU/g and remained stable throughout storage. PDM showed lower acceptability (5.77-6.50) after storage than SDM (6.67-7.03). The texture was the most appreciated attribute and hardness of the SDM increased during storage, but remained stable for PDM. The clinical trial revealed significant reductions of total cholesterol and HDL-cholesterol, as well as of immunoglobulins (A and M), and interleukin-1β in both groups during the intervention period. However, regarding intergroup changes, there were not any significant differences for all parameters evaluated (p>0.05). After the optimization of the microencapsulation process of the probiotic culture (80 mL/min, 82% and 10%, respectively for feed flow, aspiration rate, and inulin concentration), the microencapsulated probiotic strain incorporated in the SDM mousse showed the highest in vitro gastrointestinal survival (p<0.05) in the different stages of the assay, as follows: after the gastric phase: 5.68 log CFU/g (83.3%), the enteral phase I: 5.61 log CFU/g (82.3%), the enteral phase II: 5.56 log CFU/g (81.4%). Therefore, these results suggest that the presence of probiotic and prebiotics in SDM did not provide an additional effect on the health of volunteers with MetS. Additionally, the results confirm the appropriateness of the spray drying process to microencapsulate L. acidophilus La-5 using inulin as coating agent, providing increased resistance to the microencapsulated probiotic strain under in vitro gastrointestinal stress.
O objetivo deste trabalho foi adaptar uma sobremesa aerada simbiótica diet do tipo musse, processada com a adição de uma cultura probiótica de Lactobacillus acidophilus La-5 e de ingredientes prebióticos (fruto-oligossacarídeos e inulina), a partir da formulação contendo sacarose desenvolvida anteriormente, e avaliar os efeitos de sua ingestão em voluntários adultos com síndrome metabólica (MetS) durante um período de 8 semanas de intervenção. Adicionalmente, para melhorar a resistência do probiótico frente às condições gastrintestinais simuladas, otimizou-se um processo de microencapsulação da cepa probiótica. Para o desenvolvimento do produto, as formulações foram produzidas em triplicata, em que se avaliou a sobrevivência da cultura probiótica, a textura instrumental e a aceitabilidade sensorial até 112 dias de armazenamento sob congelamento (-18 oC). Em seguida, foi realizado um estudo randomizado, duplo-cego e controlado por placebo, no qual o produto desenvolvido foi administrado a quarenta e cinco indivíduos com MetS divididos em dois grupos, cada um recebendo 40 g/dia de: mousse simbiótica diet (SDM) (n=23) e musse placebo diet (PDM) sem componentes pro- e prebióticos (n=22). As amostras sanguíneas foram coletadas em jejum no início e após 8 semanas de consumo diário de ambas as musses para a determinação dos parâmetros antropométricos, bioquímicos, hematológicos, inflamatórios e imunológicos. Posteriormente, com o intuito de melhorar a sobrevivência do L. acidophilus La-5 em condições gastrointestinais simuladas in vitro, as condições de processo de microencapsulação da cepa probiótica via spray drying foram otimizadas, utilizando inulina como agente encapsulante. A viabilidade de L. acidophilus La-5 incorporados na SDM foi superior a 7,8 log UFC/g e se manteve estável ao longo do armazenamento. A PDM mostrou menor aceitabilidade (5.77-6.50) após o armazenamento do que a SDM (6.67-7.03). A textura foi o atributo mais apreciado, sendo que a dureza da SDM apresentou elevação, enquanto a da PDM manteve-se estável. O ensaio clínico revelou reduções significativas de colesterol total, colesterol-HDL, imunoglobulinas (A e M) e interleucina1β em ambos os grupos durante o período de intervenção. Entretanto, no que se refere às mudanças intergrupos, não se observou diferenças significativas para todos os parâmetros avaliados (p>0,05). Após a otimização do processo de microencapsulação da cultura probiótica (80 mL/min, 82% e 10%, respectivamente para o fluxo de alimentação, taxa de aspiração e concentração de inulina), a cepa probiótica microencapsulada incorporada a amostra SDM apresentou a maior sobrevivência gastrointestinal in vitro (p<0,05) nas diferentes etapas do ensaio, a saber: após a fase gástrica: 5,68 log UFC/g (83,3%); fase entérica I: 5,61 log UFC/g (82,3%); fase entérica II: 5,56 log UFC/g (81,4%). Portanto, esses resultados sugerem que a presença de probiótico e prebiótico na SDM não apresentou efeitos adicionais na saúde dos voluntários com MetS. Adicionalmente, os resultados confirmaram a adequação do processo de spray drying para a microencapsulação de L. acidophilus La-5 utilizando inulina como agente de revestimento, proporcionando uma maior resistência da cepa probiótica microencapsulada às condições gastrintestinais simuladas in vitro.
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Books on the topic "Synbiotic"

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Kasipathy Kailasapathy (University of Western Sydney, Claude Champagne (Agriculture and Agri-Food, Canada) Sarah Moore (University of Sydney, Australia), Australia). Synbiotic Yoghurt - A Smart Gut Food: Science, Technology and Applications. Nova Science Publishers, Incorporated, 2011.

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S.M.A. Aziz Mousavi, A. Seidavi, M. Dadashbeiki, A. Kilonzo-Nthenge, S.N. Nahashon, V. Laudadio, and V. Tufarelli. Effect of a synbiotic (Biomin®IMBO) on growth performance traits of broiler chickens. Verlag Eugen Ulmer, 2015. http://dx.doi.org/10.1399/eps.2015.78.

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A. Sozcu* and A. Ipek. Intestinal morphology, hepatic enzyme activity, serum immunoglobulin level and growth performance of broilers fed on diets supplemented with a synbiotic. Verlag Eugen Ulmer, 2017. http://dx.doi.org/10.1399/eps.2017.189.

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Panesar, Parmjit Singh, and Anil Kumar Anal, eds. Probiotics, Prebiotics and Synbiotics. Wiley, 2022. http://dx.doi.org/10.1002/9781119702160.

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Probiotics, Prebiotics, and Synbiotics. Elsevier, 2016. http://dx.doi.org/10.1016/c2015-0-01023-1.

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Bhatt, Shvetank, Neeraj Mishra, Keshav Raj Paudel, Philip Hansbro, and Kamal Dua. Synbiotics for the Management of Cancer. Springer, 2023.

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Preedy, Victor R., and Ronald Ross Watson. Probiotics, Prebiotics, and Synbiotics: Bioactive Foods in Health Promotion. Elsevier Science & Technology Books, 2015.

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Preedy, Victor R., and Ronald Ross Watson. Probiotics, Prebiotics, and Synbiotics: Bioactive Foods in Health Promotion. Elsevier Science & Technology Books, 2015.

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Panesar, Parmjit S., and Anil Kumar Anal. Probiotics, Prebiotics, and Synbiotics: Technological Advancements Towards Safety and Industrial Applications. Wiley & Sons, Incorporated, John, 2022.

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Panesar, Parmjit S., and Anil Kumar Anal. Probiotics, Prebiotics, and Synbiotics: Technological Advancements Towards Safety and Industrial Applications. Wiley & Sons, Incorporated, John, 2022.

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Book chapters on the topic "Synbiotic"

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Annapure, Uday S., and Harsh B. Jadhav. "Prebiotic and Synbiotic Foods." In Microbes for Natural Food Additives, 75–112. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5711-6_5.

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Hotchkiss, Arland T., LinShu Liu, Jeff Call, Peter Cooke, John B. Luchansky, and Robert A. Rastall. "Synbiotic Matrices Derived from Plant Oligosaccharides and Polysaccharides." In ACS Symposium Series, 69–77. Washington, DC: American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0992.ch005.

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Singh, Soibam Khogen, Sukham Munilkumar, Nilesh A. Pawar, and Pradyut Biswas. "Prebiotic–Synbiotic Nexus: Critical Dietary Role in Aquaculture." In Biotechnological Advances in Aquaculture Health Management, 237–67. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5195-3_11.

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Sirisapsombat, Vachrintr, Chaiyavat Chaiyasut, Phuttharaksa Phumcharoen, Parama Pratummas, Sasithorn Sirilun, Thamthiwat Nararatwanchai, and Phakkharawat Sittiprapaporn. "Using AUDIT Scores to Identify Synbiotic Supplement Effect in High-Risk Alcoholics." In Lecture Notes in Electrical Engineering, 143–52. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6987-0_12.

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Afoakwah, Newlove Akowuah, and Gustav Komla Mahunu. "Utilization of Jerusalem Artichoke (Helianthus tuberosus L.) Tuber as a Prebiotic and a Synbiotic." In African Fermented Food Products- New Trends, 525–36. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-82902-5_35.

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Pramaningtyas, Miranti Dewi, Rokhima Lusiantari, Titis Nurmasitoh, Ernadita Budiastuti, Qudsia Umaira Khan, Rafik Prabowo, Mohammad Alvian Subhakti, et al. "The Effects of Kefir and Jicama Synbiotic Administration on White Rat Serum Cortisol Levels After Subtotal Nephrectomy." In Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021), 462–66. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-048-0_53.

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Tolstanova, Ganna, Iryna Akulenko, Tetiiana Serhiichuk, Taisa Dovbynchuk, and Natalia Stepanova. "Pro- Pre- and Synbiotic Supplementation and Oxalate Homeostasis in 3 PM Context: Focus on Microbiota Oxalate-Degrading Activity." In Microbiome in 3P Medicine Strategies, 335–53. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-19564-8_12.

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Hoseinifar, Seyed Hossein, Yun-Zhang Sun, and Zhigzhang Zhou. "Prebiotics and Synbiotics." In Diagnosis and Control of Diseases of Fish and Shellfish, 185–88. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119152125.ch7.

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Bengmark, Stig. "Synbiotics in Human Medicine." In Therapeutic Microbiology, 307–21. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815462.ch24.

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de Vrese, Michael, and J. Schrezenmeir. "Probiotics, Prebiotics, and Synbiotics." In Food Biotechnology, 1–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/10_2008_097.

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Conference papers on the topic "Synbiotic"

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Skachkov, D. A., I. M. Volokhov, D. N. Pilipenko, and L. F. Obrushnikova. "Production technologies of fermented milk dessert with synbiotic properties." In PROCEEDINGS OF THE II INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS, SYSTEMS AND TECHNOLOGIES: (CAMSTech-II 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0092446.

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Pratummas, Parama, Thamthiwat Nararatwanchai, Chaiyavat Chaiyasut, Sasithorn Sirilun, and Phakkharawat Sittiprapaporn. "Effects of Synbiotic Supplement in Thai Smokers: A Preliminary Study." In 2019 16th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology (ECTI-CON). IEEE, 2019. http://dx.doi.org/10.1109/ecti-con47248.2019.8955396.

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Evdokimova, Svetlana, Boris Karetkin, Anna Kazanbaeva, Vera Nokhaeva, and Victor Panfilov. "A STUDY ON THE HONEY COMPOUNDS IN SYNBIOTIC COMPOSITION FOR MICROBIAL FOOD CONTAMINANTS GROWTH INHIBITION." In 20th International Multidisciplinary Scientific GeoConference Proceedings SGEM 2020. STEF92 Technology, 2020. http://dx.doi.org/10.5593/sgem2020/6.1/s25.021.

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Sagar, Poonam, Ritika Gupta, and Nitin Kumar Singhal. "Synbiotic hydrogels encapsulating iron and probiotic provide iron bioavailability equivalent to commercially available iron supplements." In 2022 IEEE International Conference on Nanoelectronics, Nanophotonics, Nanomaterials, Nanobioscience & Nanotechnology (5NANO). IEEE, 2022. http://dx.doi.org/10.1109/5nano53044.2022.9828897.

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"Kajian Karakteristik Fisikokimiawi, Mikrostruktur dan Nilai Ekonomis Synbiotic Fermented Milk Guna Menunjang Pola Hidup Sehat." In Teknologi Peternakan dan Veteriner Mendukung Kemandirian Pangan di Era Industri 4.0. Pusat Penelitian dan Pengembangan Peternakan, 2019. http://dx.doi.org/10.14334/pros.semnas.tpv-2019-p.277-283.

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Hashem, Nesrein, Nagwa El-Desoky, Nourhan Hosny, and Mohamed Shehata. "Gastrointestinal microflora homeostasis, immunity and growth performance of rabbits supplemented with innovative non-encapsulated or encapsulated synbiotic." In The 1st International Electronic Conference on Animals—Global Sustainability and Animals: Science, Ethics and Policy. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ieca2020-08894.

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Tari, Agustina, Catur Handayani, and Sri Hartati. "The Characteristics of Synbiotic Yoghurt Freeze-Drying Supplemented by Purple Sweet potato (Study on Sucrose Concentration as Cryoprotectant)." In International Conference on Applied Science and Engineering (ICASE 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/icase-18.2018.12.

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Karetkin, Boris. "NEW APPROACH FOR SYNBIOTIC COMPOSITION DEVELOPMENT BASED ON THE MODEL OF OPPORTUNISTIC BACTERIA GROWTH INHIBITION IN MIXED CULTURE." In 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/6.1/s25.104.

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Wahyuni, A. E. T. H., T. E. M. Nahak, M. C. C. Malelak, V. C. Prakasita, and S. L. Adrenalin. "The Role of Synbiotic in Cobb-strain Broiler Performance Challenged with Campylobacter jejuni as a Substitute for Antibiotic Growth Promotor (AGP)." In 10th International Seminar and 12th Congress of Indonesian Society for Microbiology (ISISM 2019). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/absr.k.210810.001.

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Widhani, Alvina, Samsuridjal Djauzi, Fransiscus D. Suyatna, Beti Ernawati Dewi, Melva Louisa, Andi Yasmon, and Susan Rahayu. "O3 Changes in gut microbiota after synbiotic supplementation in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial." In 12th European Lupus Meeting. Lupus Foundation of America, 2020. http://dx.doi.org/10.1136/lupus-2020-eurolupus.17.

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Reports on the topic "Synbiotic"

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Miao, Chenyun, Qingge Guo, Xiaojie Fang, Yun Chen, Ying Zhao, and Qin Zhang. Effects of Probiotics and Synbiotics Supplementation on Insulin Resistance in Women with Polycystic Ovary Syndrome: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0112.

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