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Journal articles on the topic 'Synbiotic Mixture'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Swanson, Kelly S., Glenn R. Gibson, Robert Hutkins, et al. "The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics." Nature Reviews Gastroenterology & Hepatology 17, no. 11 (2020): 687–701. http://dx.doi.org/10.1038/s41575-020-0344-2.

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Abstract In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively.

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He, Penglin, Yufei Wang, Jing Yang, Huayi Suo, and Jiajia Song. "The Effect of Lactiplantibacillus plantarum SHY130 and Konjac Glucomannan on the Physicochemical, Antioxidant, and Sensory Properties of Stirred Yogurt." Foods 13, no. 15 (2024): 2324. http://dx.doi.org/10.3390/foods13152324.

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The impact of konjac glucomannan (KGM)-based synbiotics on yogurt quality is not well understood. This study investigated the effects of a synbiotic mixture of KGM and the selected probiotic Lactiplantibacillus plantarum SHY130 on the physicochemical, antioxidant, and sensory properties of yogurt. The results showed that KGM significantly promoted the growth of Lactiplantibacillus plantarum SHY130. The synbiotics dramatically enhanced the count of lactic acid bacteria in yogurt during the 14 days of storage. Texture analysis indicated that the synbiotic supplement had no impact on springiness

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Kamel O. I., Marwa, Ashraf A. A. El-Komy, and Enas A. A. Farag. "The immunibiochemical effect of synobiotic and phytobiotic in vaccinated and unvaccinated chicken." International Journal of Pharmacology and Toxicology 9, no. 1 (2021): 56. http://dx.doi.org/10.14419/ijpt.v9i1.31537.

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The current study was conducted to evaluate the effects of dietary supplementation of synbiotics, phytobiotics and their mixture on some blood parameters with respct to kidney and liver functions and some histological criteria of broilers. A total of 200 broiler chicks were randomly chosen and divided into eight groups (25 bird in each). The first four groups were unvaccinated chicken and allotted to four dietary treatments, either fed a basal diet (group 1) or the same diet supplemented with 1g synbiotic /kg body weight ( group 2) , 1g phytobiotic /kg body weight (group 3) and 1g synbiotic pl

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Jung, Susie, Kwang-Min Kim, Sung-Min Youn, and Kyu-Nam Kim. "A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effects of Multi-Strain Synbiotic in Patients with Functional Diarrhea and High Fecal Calprotectin Levels: A Pilot Study." Nutrients 14, no. 23 (2022): 5017. http://dx.doi.org/10.3390/nu14235017.

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Synbiotics, including probiotics and prebiotics, are useful for patients with functional bowel disorders. However, which synbiotics are beneficial for patients with which diseases, especially those with functional diarrhea (FDr) with high fecal calprotectin levels, is currently unknown. FDr is an extension of irritable bowel syndrome with diarrhea (IBS-D). Although fewer studies have been conducted on FDr compared to IBS-D, its importance is increasing as its prevalence increases. The aim of this study was to evaluate the effects of a synbiotic containing a mixture of Lactobacillus and Bifidob

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Mangisah, I., and N. Suthama. "The effect of synbiotic through feed and drinking water on growth performance and nutrient digestibility of Tegal duck." IOP Conference Series: Earth and Environmental Science 951, no. 1 (2022): 012017. http://dx.doi.org/10.1088/1755-1315/951/1/012017.

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Abstract Synbiotics are a combination of probiotics and prebiotics that have a positive effect on livestock performance. The method of giving synbiotics as a growth supplement needs to be studied to get the best results. This study aimed to investigate the effect of administering synbiotic (a mixture of Lactobacillus casei and porang tuber extracts (LCPE) in water or as feed supplement on performance and nutrient digestibility of Tegal duck. The research used a total number of 240-day old ducks with an average body weight of 47.84 ± 6.32 g. The ducks were weighed and distributed into 24 groups

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Sergeev, Igor N., Thamer Aljutaily, Gemma Walton, and Eduardo Huarte. "Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity." Nutrients 12, no. 1 (2020): 222. http://dx.doi.org/10.3390/nu12010222.

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Targeting gut microbiota with synbiotics (probiotic supplements containing prebiotic components) is emerging as a promising intervention in the comprehensive nutritional approach to reducing obesity. Weight loss resulting from low-carbohydrate high-protein diets can be significant but has also been linked to potentially negative health effects due to increased bacterial fermentation of undigested protein within the colon and subsequent changes in gut microbiota composition. Correcting obesity-induced disruption of gut microbiota with synbiotics can be more effective than supplementation with p

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7

Jerez-Morales, Alonso, José S. Merino, Sindy T. Díaz-Castillo, et al. "The Administration of the Synbiotic Lactobacillus bulgaricus 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model." Toxins 13, no. 3 (2021): 192. http://dx.doi.org/10.3390/toxins13030192.

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Indoxyl sulfate (IS) is involved in the progression of chronic kidney disease (CKD) and in its cardiovascular complications. One of the approaches proposed to decrease IS is the administration of synbiotics. This work aimed to search for a probiotic strain capable to decrease serum IS levels and mix it with two prebiotics (inulin and fructooligosaccharide (FOS)) to produce a putative synbiotic and test it in a rat CKD model. Two groups of Sprague-Dawley rats were nephrectomized. One group (Lac) received the mixture for 16 weeks in drinking water and the other no (Nef). A control group (C) incl

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Lysenko, Yuri, Albina Luneva, Vladimir Belyak, and Maria Lifentsova. "The effect of a synbiotic feed additive on the body of young pigs." BIO Web of Conferences 139 (2024): 11004. http://dx.doi.org/10.1051/bioconf/202413911004.

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The publication presents the results of the effect on the body of young pigs reared with a synbiotic feed additive. The synbiotic product consists of two components: lyophilized probiotic cultures isolated from the digestive system of pigs, and a vegetable prebiotic filler. These ingredients are combined into a dry mixture to form a synbiotic with pro- and prebiotic properties. The effect of the additive on the viability of livestock, live weight and its growth, indicators of feed consumption were studied, and the results of general and biochemical blood analysis of experimental animals were a

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9

Tarabees, Reda, Shehata A, Allam S, Dawood A, EL A, and Gaber M. "Effects of Probiotics and Prebiotics and their Combinations on Growth Performance and Intestinal Microbiota of Broilers Infected with Mixed Salmonellae." Alexandria Journal of Veterinary Sciences 77, no. 1 (2023): 12. http://dx.doi.org/10.5455/ajvs.143849.

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In the present study, a total of 273 commercial Cobb chicks were subjectively divided into seven groups to evaluate the effects of a probiotic mixture, prebiotic (Isomaltooligosaccharide), and their combination additions on growth performance, intestinal microbiome, caecal colonisation of Salmonella of broilers challenged with S. enteritidis and S. typhimurium. The groups included G01: basal diet (negative control), G02; basal diet and challenged with Salmonella on 3rd day of life (positive control), G03: received probiotic mixture in drinking water and then challenged with Salmonella, G04: re

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10

SALAM, SADIA, MD SHAHJAHAN, and MD SADIQUL ISLAM. "Effects of synbiotics on innate immunity in the stinging catfish (Heteropneustes fossilis)." Bangladesh Journal of Fisheries 35, no. 2 (2023): 99–108. http://dx.doi.org/10.52168/bjf.2023.35.09.

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An experiment was conducted to evaluate the effects of dietary synbiotic (a group of probiotics at a dose of 3.09×108CFU/ml with a mixture of prebiotics) supplementations on the innate immunity of stinging catfish, Heteropneustes fossilis. A total of 1000 H. fossilis fries with an average initial weight of 2.03±0.15 g and an average length of 6.96±0.45 cm was randomly stocked into four groups T1 (control: no synbiotic), T2 (4%), T3 (6%), T4 (8%) groups. During the 45-day feeding trial, fish were fed twice a day at a rate of 3% body weight. Additionally, T2 (4% synbiotic), T3 (6% synbiotic), an

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Piatek, J., H. Sommermeyer, M. Bernatek, et al. "Persistent infection by Salmonella enterica servovar Typhimurium: are synbiotics a therapeutic option? – a case report." Beneficial Microbes 10, no. 2 (2019): 211–17. http://dx.doi.org/10.3920/bm2018.0080.

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Little is known about the prevalence of persistent human infections by nontyphoidal Salmonella (NTS). Recently published study results indicate that a small fraction (at least 2.2%) of NTS-infected patients continue to shed Salmonella for an extended period of time (up to years). Despite the recommendation not to use antibiotics for the treatment of uncomplicated NTS-Salmonella infection, little treatment guidance is available. Clinical findings from a NTS-patient indicate that administration of synbiotics (probiotic bacteria plus prebiotic) might be considered as a treatment option. We report

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12

Wu, Min-Zi, Tsai-Chien Sun, Yu-Wen Huang, et al. "Bacillus coagulans BACO-17 Alone or in Combination with Galacto-Oligosaccharide Ameliorates Salmonella-Induced Diarrhea and Intestinal Inflammation." Processes 10, no. 10 (2022): 2123. http://dx.doi.org/10.3390/pr10102123.

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In this study, a diarrhea model was established by exposing rats to appropriate antibiotics and Salmonella. After an in vitro screening of prebiotics, fructo-oligosaccharide and galacto-oligosaccharide (GOS) were selected; their synbiotic potential and ability to ameliorate diarrhea symptoms and intestinal inflammation with Bacillus coagulans BACO-17 were evaluated in vivo. After a 27-day feeding experiment including antibiotic intervention and Salmonella infection, it was found that using B. coagulans BACO-17 alone and in combination with GOS as a synbiotic could render a better recovery by l

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13

Holma, Reetta, Riina A. Kekkonen, Katja Hatakka, et al. "Low serum enterolactone concentration is associated with low colonicLactobacillus–Enterococcuscounts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study." British Journal of Nutrition 111, no. 2 (2013): 301–9. http://dx.doi.org/10.1017/s0007114513002420.

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The aims of the present study were to assess the possible differences in faecal microbiota between men with a low serum enterolactone concentration and those with a high concentration, and to investigate the impact of a synbiotic mixture on serum enterolactone concentration in men with a low concentration. We compared faecal microbiota between ten men with the lowest serum enterolactone concentration and ten men with the highest concentration at recruitment (n84). Furthermore, we carried out a randomised, double-blind, placebo-controlled, cross-over intervention study (6-week intervention peri

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14

Swanson, Kelly S. "32 Biotics: Are there differences?" Journal of Animal Science 102, Supplement_3 (2024): 123. http://dx.doi.org/10.1093/jas/skae234.143.

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Abstract In companion animals, the search for dietary ingredients and supplements that may promote health and longevity continues. Because stool quality issues and gastrointestinal diseases are common, substances addressing gastrointestinal health are of interest and some of the most heavily studied. Given the importance that microbiota have on host health and disease, many strategies function by directly or indirectly influencing the microbial species that inhabit the gut. Dietary fibers may impact gut health by maintaining stool quality, providing laxation, reducing fecal odor, and modulatin

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15

Noll, Matthias, Michael Jäger, Leonie Lux, Christian Buettner, and Michaela Axt-Gadermann. "Improvement of Atopic Dermatitis by Synbiotic Baths." Microorganisms 9, no. 3 (2021): 527. http://dx.doi.org/10.3390/microorganisms9030527.

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Atopic dermatitis (AD) is a widespread chronic inflammatory dermatologic disorder. This randomized, double-blind study aims to evaluate the effect of synbiotic baths with a defined mixture of six viable lactic acid bacteria (LAB) and prebiotics, without bacteria and prebiotics and placebo baths without prebiotics and bacteria to treat AD patients over a period of 14 days. Therefore, AD patients were randomly assigned into three groups using synbiotic (n = 7), prebiotics (n = 8) or placebo baths (n = 7). Severity of AD was evaluated over time by using severity scoring of atopic dermatitis (SCOR

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16

Lee, Hyo Lim, Jong Min Kim, Jong Hyun Moon, et al. "Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice." International Journal of Molecular Sciences 24, no. 1 (2022): 90. http://dx.doi.org/10.3390/ijms24010090.

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This study was conducted to compare the synbiotic activity between Corni fructus (C. fructus) and Limosilactobacillus reuteri (L. reuteri) on dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. C. fructus (as prebiotics, PRE), L. reuteri (as probiotics, PRO), and synbiotics (as a mixture of L. reuteri and C. fructus, SYN) were fed to mice for 3 weeks. Consumption of PRE, PRO, and SYN ameliorated colitis symptoms in body weight, large intestinal length, and serum albumin level. Moreover, SYN showed a synergistic effect on intestinal permeability and intestina

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17

Choi, Bo-Ra, Eun-Young Kwon, Hye-Jin Kim, and Myung-Sook Choi. "Role of Synbiotics Containing d-Allulose in the Alteration of Body Fat and Hepatic Lipids in Diet-Induced Obese Mice." Nutrients 10, no. 11 (2018): 1797. http://dx.doi.org/10.3390/nu10111797.

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The effects of allulose and two probiotic species on diet-induced obese (DIO) mice were investigated. Lactobacillus sakei LS03 (109 cfu/day) and Leuconostoc kimchii GJ2 (109 cfu/day) were used as probiotics, and allulose (AL) as a prebiotic. The synergistic effect of prebiotics and probiotics in improving obesity was evaluated. Orally fed Lactobacillus sakei LS03 (LS) or Leuconostoc kimchii GJ2 (GJ), significantly decreased hepatic triglyceride (TG) and fatty acid (FA) compared to the high-fat diet (HFD) control. AL markedly decreased visceral adiposity and pro-inflammatory adipokines (leptin

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18

Trubnikova, А., О. Chabanova, S. Bondar, Т. Sharakhmatova, and Т. Nedobijchuk. "MATHEMATICAL MODELING OF OPTIMIZED RECEPTURAL OF LOW-LACTOSE SYNBIOTIC YOGHOURT ICE CREAM." Animal Science and Food Technology 11, no. 2 (2020): 73–82. http://dx.doi.org/10.31548/animal2020.02.083.

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Optimization of the formulation of synbiotic yogurt ice cream low-lactose using lactose-free protein concentrate of buttermilk and yogurt with low lactose content is the goal of expanding the range of low-lactose dairy products and improving the functional and health properties of ice cream. Low-lactose ice cream formulation optimization was performed using a gradient numerical method, namely conjugated gradients (Conjugate Gradient). The optimization algorithm is implemented in Mathcad. An array of data with a set of indicators for the choice of a rational ratio of lactose-free protein concen

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Atepela, Josephine Herwita. "Promise of Synbiotic in Gut-Kidney Axis." Cermin Dunia Kedokteran 51, no. 1 (2024): 51–54. http://dx.doi.org/10.55175/cdk.v51i1.617.

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Human microbiota plays a role in protecting human health. Change in the microbial composition will lead to an imbalance between the beneficial and potentially harmful bacteria, leading to “dysbiosis”. The pathogenic interconnection between gut microbiota and kidney diseases is called the gut–kidney axis, which is implicated in a wide range of clinical manifestations such as CKD (chronic kidney disease), AKI (acute kidney injury), hypertension, nephrolithiasis, IgA nephropathy, hemodialysis, and peritoneal dialysis. Synbiotic, a mixture of probiotics and prebiotics are reported to be beneficial

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20

Ruiz, Lorena, Ana Belén Flórez, Borja Sánchez, et al. "Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM-1®) Displays In Vitro Activity against Some Intestinal Pathogens." Nutrients 12, no. 11 (2020): 3259. http://dx.doi.org/10.3390/nu12113259.

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Certain non-digestible oligosaccharides (NDO) are specifically fermented by bifidobacteria along the human gastrointestinal tract, selectively favoring their growth and the production of health-promoting metabolites. In the present study, the ability of the probiotic strain Bifidobacterium longum subsp. infantis CECT7210 (herein referred to as B. infantis IM-1®) to utilize a large range of oligosaccharides, or a mixture of oligosaccharides, was investigated. The strain was able to utilize all prebiotics screened. However, galactooligosaccharides (GOS), and GOS-containing mixtures, effectively

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21

DONEVA, Maria, Iliana NACHEVA, and Petya METODIEVA. "PARTICLE DISTRIBUTION IN GRANULAR SYNBIOTIC PRODUCTS." AgroLife Scientific Journal 11, no. 1 (2022): 56–62. http://dx.doi.org/10.17930/agl202216.

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This article presents an analysis of the particle distribution of granular lyophilized synbiotic products. The main purpose of the present study is to find a relationship between the particle size distribution and the varying component in the composition of the products. Particle size measurements were performed with an ANALYSETTE 22 NanoTec plus analyzer. The results obtained we then subjected to statistical analysis to study the distribution properties of functional food samples. It has been found that for the preparation of granules with a low degree of dusting it is optimal to use 10% sucr

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Saracila, Mihaela, Arabela Elena Untea, and Tatiana Dumitra Panaite. "Evaluation of the Effect of Synbiotic in Piglets’ Diet on the Nutritional Quality of Pork." Archiva Zootechnica 24, no. 2 (2021): 67–75. http://dx.doi.org/10.2478/azibna-2021-0014.

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Abstract The purpose of the study was to increase the nutritional quality of pork, and to investigate the effect of the synbiotic on the oxidative stability of lipid. A 4 weeks experiment was performed on 8 weaned piglets (age 47 days, TOPIGS), divided into 2 groups (C, E). The control group (C) received a conventional diet, while the experimental group (E) included a diet supplemented with organic Zn and 10 g/kg synbiotic mixture. The productive parameters were evaluated. After slaughtered, muscle (tenderloin, shoulder, loin, ham and belly) and organs samples (liver, spleen and kidney) were c

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23

Sudheer Chowdary Bodepudi, Venu Babu Chennupati, Sushma Ch, Poornachandra Rao. K, and Sukanya Manam. "Development of synbiotic powder preparation from reduced starch and fermented soyabean to improve gut health." International Journal of Science and Research Archive 16, no. 1 (2025): 1002–7. https://doi.org/10.30574/ijsra.2025.16.1.2000.

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Synbiotics are combination of both prebiotics and probiotics containing product mainly involved in the improving of gut health. These are emerging high demand nutraceuticals commercially around the world which was expecting of gaining 1.5 billion USD during the year 2023. Various countries like North America, UK, Germany, France, China and India are focused on this product development. Synbiotics plays a major role in the prevention of various gut related disorders like irritable bowel syndrome, gastro esophageal reflux disease, lactose intolerance etc. Our study was aimed to prepare the synbi

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KARAGÜL, Özlem, and Sedef Nehir EL. "Cereal-based fermented synbiotic instant powders: a dessert practice." Ege Üniversitesi Ziraat Fakültesi Dergisi 60, no. 4 (2023): 571–79. http://dx.doi.org/10.20289/zfdergi.1336843.

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Objective: This study was aimed to develop synbiotic and probiotic instant powder mixtures that can be used in food products to meet the increasing interest of consumers in functional foods.  Materials and Methods Cereal flours (oat, rice, wheat), sesame, cranberry, chestnut and milled germinated grains (lentil, mung bean) were blended and autoclaved then subjected to fermentation process using the Lactobacillus plantarum strain. A part of the porridge was conventionally dried (FPP) and skim milk powder+fructooligosaccharide+inulin mixture as prebiotic sources were added to the other par

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Cappello, C., F. Tremolaterra, D. Consalvo, C. Ciacci, and P. Iovino. "P.1.254: A SYNBIOTIC MIXTURE IMPROVES FLATULENCE IN IRRITABLE BOWEL SYNDROME." Digestive and Liver Disease 43 (March 2011): S232. http://dx.doi.org/10.1016/s1590-8658(11)60482-9.

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Guzhvynska, S. О., А. P. Paliy та О. M. Kornieikov. "Study of the stability of the main indicators of probiotic cultures Lactobacillus рlantarum No. 7 and Bifidobacterium adolescentis no. 17 in the bacterial mixture during storage". Veterinary Medicine: inter-departmental subject scientific collection, № 107 (8 листопада 2021): 70–74. http://dx.doi.org/10.36016/vm-2021-107-12.

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The article presents the results of studying the stability of the main indicators of probiotic cultures Lactobacillus plantarum No. 7 and Bifidobacterium adolescentis No. 17 as part of a bacterial mixture during storage. The prebiotic component lactulose was added to the bacterial mixture at a concentration of 1.5%. The stability of the synbiotic bacterial mixture in vials and capsules when stored under appropriate conditions (in a place protected from light, at a temperature of 4–8°C) has been studied. Experiments have shown that the preservation of the liquid form of the bacterial mixture wi

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Tletseruk, I. R., N. A. Yurina, D. A. Yurin, et al. "Ensuring efficiency in broiler meat production with a set of innovative approaches to poultry feeding." IOP Conference Series: Earth and Environmental Science 981, no. 2 (2022): 022104. http://dx.doi.org/10.1088/1755-1315/981/2/022104.

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Abstract The article deals with the study of the effect of synbiotic feed additive with pro-, prebiotic and sorption properties in the feeding of broiler chickens up to 37 days of age. The activity of specially selected specific bacterial strains of the feed additive increased due to the innovative approach to the selection of microbial strains composition, unique production method and lyophilic drying method. Adding the studied feed additive “Synbiosorb-2” in the amount of 0,10 % of the weight of the feed mixture proved to be the best dosage and increased the live weight of broiler chickens b

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Linh, Nguyễn Thị Huế, Nguyễn Thị Xuân Hồng, Trần Thị Thúy Hằng та Nguyễn Ngọc Phước. "ẢNH HƯỞNG CỦA CHẾ PHẨM SYNBIOTIC CHỨA VI KHUẨN SINH AXIT LACTIC Lactococcus lactis VÀ FRUCTOOLIGOSACCHARIDE LÊN MỘT SỐ CHỈ TIÊU MIỄN DỊCH CỦA TÔM THẺ CHÂN TRẮNG (Litopenaeus vannamei)". Tạp chí Khoa học và công nghệ nông nghiệp, Trường Đại học Nông Lâm Huế 5, № 1 (2021): 2310–19. http://dx.doi.org/10.46826/huaf-jasat.v5n1y2021.492.

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Nghiên cứu này bước đầu đánh giá ảnh hưởng của chế phẩm synbiotic gồm vi khuẩn sinh axit lactic Lactococcus lactis và fructooligosaccharide lên các chỉ tiêu miễn dịch của tôm thẻ chân trắng (Litopenaeus vannamei). Tôm thí nghiệm (khối lượng ban đầu 5 ± 0,6 g/con) được cho ăn thức ăn công nghiệp không có hoặc có chế phẩm synbiotic với hàm lượng phối trộn vi khuẩn L. lactis 108 CFU/mL và lần lượt 4 hàm lượng của fructooligosaccharide là 0,1; 0,2; 0,5 và 1%. Sau 30 ngày cho tôm ăn thức ăn thử nghiệm, tiến hành thu mẫu máu tôm để phân tích các chỉ tiêu miễn dịch. Kết quả cho thấy tổng số tế bào má

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Pistol, Gina Cecilia, Daniela Eliza Marin, Catalin Dragomir, and Ionelia Taranu. "Synbiotic combination of prebiotic grape pomace extract and probiotic Lactobacillus sp. reduced important intestinal inflammatory markers and in-depth signalling mediators in lipopolysaccharide-treated Caco-2 cells." British Journal of Nutrition 121, no. 3 (2018): 291–305. http://dx.doi.org/10.1017/s0007114518003410.

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AbstractInflammatory bowel diseases (IBD) are a major problem for public health, with an increased incidence and impact on life quality. The effect of pre- and probiotic combination has been less studied in IBD. Using genomic and proteomic array technologies, this study examined the efficacy of a new combination of natural alternatives: prebiotics (grape pomace extract, GP) and probiotics (lactobacilli mixture, Lb mix) on inflammation and intracellular signalling routes in a cellular model of inflammation. Caco-2 cells challenged with lipopolysaccharide (LPS) for 4 h were treated with GP extra

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Piatek, Jacek, Hanna Krauss, Arleta Ciechelska-Rybarczyk, Malgorzata Bernatek, Paulina Wojtyla-Buciora, and Henning Sommermeyer. "In-Vitro Growth Inhibition of Bacterial Pathogens by Probiotics and a Synbiotic: Product Composition Matters." International Journal of Environmental Research and Public Health 17, no. 9 (2020): 3332. http://dx.doi.org/10.3390/ijerph17093332.

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A variety of activities potentially contribute to the beneficial effects of probiotic bacteria observed in humans. Among these is a direct inhibition of the growth of pathogenic bacteria in the gut. The present study characterizes head-to-head the in-vitro pathogen growth inhibition of clinically relevant infectious bacterial strains by different types of probiotics and a synbiotic. In-vitro growth inhibition of Escherichia (E.) coli EPEC, Shigella (Sh.) sonnei, Salmonella (S.) typhimurium, Klebsiella (K.) pneumoniae and Clostridioides (C.) difficile were determined. Investigated products were

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Kairalla, Majdi A., Abdalhakim A. Aburas, and Kurmuan A. Omar. "Effect of Probiotic, Prebiotic, Synbiotic and Medicinal Plants on Productive Performance of Broilers Fed on Different Levels of Protein." Al-Mukhtar Journal of Sciences 33, no. 4 (2018): 306–22. http://dx.doi.org/10.54172/mjsc.v33i4.298.

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The aim of this study was to investigate the response of broilers fed on test diets containing non-antibiotic growth promoters; Probiotic (BioPlus 2B), Prebiotic (TechnoMos), Synbiotic, and medicinal herbs (Mixture of Origanum majorana, Foeniculum vulgare, and Carum carvi in ratio 1:1:1), each within two dietary protein levels (normal and low), on these broiler performance. The study was carried out at the Poultry Research Center, Faculty of Agriculture; Alexandria University, Egypt. The experimental period lasted for 42 days. A total number of 500 days from Cobb broiler chicks, with similar a

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Lesniewska, Violetta, Ian Rowland, Patrice D. Cani, Audrey M. Neyrinck, Nathalie M. Delzenne, and Patrick J. Naughton. "Effect on Components of the Intestinal Microflora and Plasma Neuropeptide Levels of Feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and Inulin to Adult and Elderly Rats." Applied and Environmental Microbiology 72, no. 10 (2006): 6533–38. http://dx.doi.org/10.1128/aem.00915-06.

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ABSTRACT The aim of this study was to compare the effects of the mixture of Lactobacillus delbrueckii subsp. rhamnosus strain GG, Bifidobacterium lactis Bb12, and inulin on intestinal populations of lactobacilli, bifidobacteria, and enterobacteria in adult and elderly rats fed the same (in quality and quantity) diet. The portal plasma levels of two neuropeptides, neuropeptide Y (NPY) and peptide YY (PYY), were also evaluated to assess the physiological consequences of the synbiotic treatment for the gastrointestinal (GI) tracts of rats of different ages. Adult (n = 24) and elderly (n = 24) mal

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Quero, Carmen Daniela, Pedro Manonelles, Marta Fernández, et al. "Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study." Nutrients 13, no. 4 (2021): 1321. http://dx.doi.org/10.3390/nu13041321.

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The main objective of this research was to carry out an experimental study, triple-blind, on the possible immunophysiological effects of a nutritional supplement (synbiotic, Gasteel Plus®, Heel España S.A.U.), containing a mixture of probiotic strains, such as Bifidobacterium lactis CBP-001010, Lactobacillus rhamnosus CNCM I-4036, and Bifidobacterium longum ES1, as well as the prebiotic fructooligosaccharides, on both professional athletes and sedentary people. The effects on some inflammatory/immune (IL-1β, IL-10, and immunoglobulin A) and stress (epinephrine, norepinephrine, dopamine, seroto

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Laue, Christiane, Ekaterina Papazova, Angelika Pannenbeckers, and Jürgen Schrezenmeir. "Effect of a Probiotic and a Synbiotic on Body Fat Mass, Body Weight and Traits of Metabolic Syndrome in Individuals with Abdominal Overweight: A Human, Double-Blind, Randomised, Controlled Clinical Study." Nutrients 15, no. 13 (2023): 3039. http://dx.doi.org/10.3390/nu15133039.

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L. fermentum strains K7-Lb1, K8-Lb1 and K11-Lb3 were found to suppress Th1 and Th2 response and to enhance defensin release by enterocytes, respectively. Based on these anti-inflammatory actions, we investigated the effect of these strains on traits of metabolic syndrome, which is driven by low-grade inflammation. In a double-blind, randomised, placebo-controlled clinical trial with three parallel arms, 180 individuals with abdominal overweight were administered for 3 months with (1) placebo; (2) probiotic, comprising L. fermentum strains; or (3) synbiotic, comprising the strains + acacia gum

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Xu, Jie, Irini Lazou Ahrén, Olena Prykhodko, Crister Olsson, Siv Ahrné, and Göran Molin. "Intake of Blueberry Fermented byLactobacillus plantarumAffects the Gut Microbiota of L-NAME Treated Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/809128.

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Prebiotics, probiotics, or synbiotics can be used as means to regulate the microbiota to exert preventative or beneficial effects to the host. However, not much is known about the effect of the gut microbiota on hypertension which is a major risk factor of cardiovascular disease and also a symptom of the metabolic syndrome. TheNG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats were used in order to test the effect of a synbiotic dietary supplement ofLactobacillus plantarumHEAL19 either together with fermented blueberry or with three phenolic compounds synthesized during fermen

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Rosida and S. S. Santi. "Functional Effect of Lesser Yam Symbiotic Yoghurt on Hypercholesterolemia Wistar Rats." MATEC Web of Conferences 372 (2022): 02001. http://dx.doi.org/10.1051/matecconf/202237202001.

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Synbiotic lesser yam yoghurt is fermented drink made from the mixture of cow’s milk and lesser yam extract which has functional benefits. Lesser yam yoghurt contains lactic acid bacteria, lactic acid, inulin, and soluble fiber which can improve the lipid profile of hypercholesterolemia sufferers. This study aims to determine the effect of the intake of lesser yam yoghurt on the lipid profile of hypercholesterolemia wistar rats. This study used nested randomized design with two factors, the first factor was a feeding group (0,1,2,3,4 ml/day, while the second factor was the time of blood collect

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Anbalagan, Charumathi, Sangeetha Kadapakkam Nandabalan, Pavithra Sankar, et al. "Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health." Biomolecules 14, no. 3 (2024): 344. http://dx.doi.org/10.3390/biom14030344.

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The eubiotic state of the gut microbiota is primarily brought about by various probiotic species that colonize the gut. It is becoming very clear that the probiotic-metabolite mixtures in the gut luminal milieu is central in establishing cross-kingdom signalling networks to maintain gut-multi-organ axes health. Culturally, different fermented foods and beverages have been regional staples since ancient times, and are known to be enriched with probiotics. However, regional variations including the environment, the staple food source (prebiotics), and fermentation methods, among other factors, i

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Thanippilly, Antony J., Sachin Kumar, Vinay V. Varada, Nitin Tyagi, and Ashish K. Samanta. "Growth performance and gut health of Murrah buffalo calves fed with developed novel synbi- otic formulation." Revista Científica de la Facultad de Ciencias Veterinarias 33, Suplemento (2023): 133–34. https://doi.org/10.52973/rcfcv-wbc020.

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The present study aimed to develop a novel synbiotic formulation by screening different prebiotics as a substrate for autochthonous Lactobacillus spp. and studying their effects on the gut health and performance of buffalo calves. Ligilactobacillus salivarius BF17 (NCBI GenBank Accession No-MG966326), a potential probiotic previously isolated from Murrah buffalo calves, was chosen and evaluated for the best prebiotic substrate by screening five different prebiotics (fructo oligosaccharides, mannan oligosaccharides, inulin, corn dextrin, and wheat dextrin). Then, 23 neonatal buffalo calves were

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Śliżewska, Katarzyna, and Agnieszka Chlebicz-Wójcik. "The In Vitro Analysis of Prebiotics to Be Used as a Component of a Synbiotic Preparation." Nutrients 12, no. 5 (2020): 1272. http://dx.doi.org/10.3390/nu12051272.

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Prebiotics are food components that are selectively fermented by beneficial microbiota and which confer a health benefit. The aim of the study was to select a prebiotic for the chosen probiotic strains to create a synbiotic. The impact of prebiotics (inulin, maltodextrin, corn starch, β-glucan, and apple pectin) on five Lactobacillus spp. strains’ growth and metabolites synthesis (lactic, acetic, propionic, and butyric acids, ethanol, and acetaldehyde) was tested by the plate count method and by high-performance liquid chromatography, respectively. Moreover, the differences in the ratio of D(−

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Say, Pisey, Sukkrit Nimikul, Anurak Bunnoy, Uthairat Na-Nakorn, and Prapansak Srisapoome. "Long-Term Application of a Synbiotic Chitosan and Acinetobacter KU011TH Mixture on the Growth Performance, Health Status, and Disease Resistance of Hybrid Catfish (Clarias gariepinus × C. macrocephalus) during Winter." Microorganisms 11, no. 7 (2023): 1807. http://dx.doi.org/10.3390/microorganisms11071807.

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The effects of potential synbiotic chitosan and Acinetobacter KU011TH mixture on growth performance, immune response, and A. hydrophila resistance were investigated for the first time. The control group was fed a basal diet (A), and group B was given the formula B diet that was supplemented with chitosan at 20 mL/kg diet via top dressing. The other synbiotic groups, C, D, and E, were top-dressed with the target probiotics at 1 × 108, 1 × 109, and 1 × 1010 CFU/kg diet, respectively, and coated with the same concentration of chitosan. Fish were continuously fed the five different feeds for 16 we

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Castro-Pérez, Beatriz I., Víctor H. Núñez-Benítez, Alfredo Estrada-Angulo, et al. "Evaluation of standardized mixture of synbiotic-glyconutrients supplemented in lambs finished during summer season in tropical environment: growth performance, dietary energetics, and carcass characteristics." Canadian Journal of Animal Science 102, no. 1 (2022): 155–64. http://dx.doi.org/10.1139/cjas-2020-0202.

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Twenty-four Pelibuey × Katahdin lambs (36.4 ± 2.9 kg initial weight) were used in a 77 d feeding trial in a randomized complete block design to evaluate the influence of a standardized synbiotic-glyconutrient combination (GLY) on growth performance, dietary energetic, and carcass characteristics of lambs finished during a period of high ambient temperature. Dietary treatments consisted of a high-energy basal diet supplemented (% of diet dry matter basis) with 0% versus 0.4% GLY. Throughout the study, the average temperature humidity index (THI) was 76.23, corresponding to the “alert” range, bu

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Pimenta, Fabio S., Maria Luaces-Regueira, Alyne MM Ton, et al. "Mechanisms of Action of Kefir in Chronic Cardiovascular and Metabolic Diseases." Cellular Physiology and Biochemistry 48, no. 5 (2018): 1901–14. http://dx.doi.org/10.1159/000492511.

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The gut microbiota maintains a complex mutual interaction with different organs of the host. Whereas in normal conditions this natural community of trillions of microorganisms greatly contributes to the human health, gut dysbiosis is related with onset or worsening of diverse chronic systemic diseases. Thus, the reestablishment of gut microbiota homeostasis with consumption of prebiotics and probiotics may be a relevant strategy to prevent or attenuate several cardiovascular and metabolic complications. Among these functional foods, the synbiotic kefir, which is a fermented milk composed of a

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Ramírez-Damián, Morayma, Cynthia Garfias-Noguez, Luis G. Bermúdez-Humarán, and María Elena Sánchez-Pardo. "Synbiotic Microencapsulation of Lactobacillus Strains from Mexican Fermented Beverages for Enhanced Probiotic Functionality." Molecules 30, no. 5 (2025): 1185. https://doi.org/10.3390/molecules30051185.

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Synbiotics, which combine probiotics and prebiotics, represent an innovative approach to developing functional foods with enhanced health benefits compared to their individual components. This study focuses on the production of synbiotics through the microencapsulation of Lactobacillus strains isolated from traditional Mexican fermented beverages, contributing to the advancement of technologies for functional food development. Three Lactobacillus strains (Lacticaseibacillus rhamnosus LM07, Lactiplantibacillus plantarum LM19, and Levilactobacillus brevis LBH1070) were microencapsulated by spray

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van der Aa, L. B., R. Lutter, H. S. A. Heymans, et al. "No detectable beneficial systemic immunomodulatory effects of a specific synbiotic mixture in infants with atopic dermatitis." Clinical & Experimental Allergy 42, no. 4 (2011): 531–39. http://dx.doi.org/10.1111/j.1365-2222.2011.03890.x.

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Ahmed, Yasir Rebh, Mohammed. Jassim Jaffar, and Hassan. A. Alasadi Majid. "The effect of the synergistic mixture of oyster mushroom Pleurotus ostreatus and beta-glucan added to the diet on the productive performance of broilers under heat stress." GSC Advanced Research and Reviews 14, no. 3 (2023): 179–86. https://doi.org/10.5281/zenodo.7928755.

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Current study showed the effect of adding the synergistic mixture of oyster mushrooms and beta-glucans on the productive performance of broilers under heat stress. 300 one-day-old chicks (Ross 308) were used and randomly distributed to four-treatments. Control treatment was fed standard diet. While the second, third and fourth treatments were fed starter ration with addition synergistic mixture at level (0.5, 1, and 1.5) g / kg. while 0.250, 0.5, 0.750) g/kg of oyster mushroom and beta-glucans for the same treatments, respectively were added to final diet .Results showed a significant eff

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Swe, Zin Myo, Thapakorn Chumphon, Marutpong Panya, Kanjana Pangjit, and Saran Promsai. "Evaluation of Nano-Wall Material for Production of Novel Lyophilized-Probiotic Product." Foods 11, no. 19 (2022): 3113. http://dx.doi.org/10.3390/foods11193113.

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Lyophilization is one of the most used methods for bacterial preservation. In this process, the cryoprotectant not only largely decreases cellular damage but also plays an important part in the conservation of viability during freeze-drying. This study investigated using cryoprotectant and a mixture of the cryoprotectant to maintain probiotic activity. Seven probiotic strains were considered: (Limosilactobacillus reuteri KUKPS6103; Lacticaseibacillus rhamnosus KUKPS6007; Lacticaseibacillus paracasei KUKPS6201; Lactobacillus acidophilus KUKPS6107; Ligilactobacillus salivarius KUKPS6202; Bacillu

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El-Nobi, Gamal, Mohammed Hassanin, Alshimaa A. Khalil та ін. "Synbiotic Effects of Saccharomycescerevisiae, Mannan Oligosaccharides, and β-Glucan on Innate Immunity, Antioxidant Status, and Disease Resistance of Nile Tilapia, Oreochromis niloticus". Antibiotics 10, № 5 (2021): 567. http://dx.doi.org/10.3390/antibiotics10050567.

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Synbiotic (SYN) additives were assessed as an antibiotic alternative on the effects on the nonspecific immune response and disease resistance of O. niloticus to P. aeruginosa. Healthy fish (n = 120, average initial weight 18 ± 2 g) were allotted randomly into four experimental groups (3 replicates for each); 1) a control group with no additives (CON), 2) basal diet complemented with 0.1 g kg–1 diets of norfloxacin, NFLX, 3) basal diet fortified with 1 mL kg–1 diet of SYN, and 4) basal diet complemented with a mixture of NFLX and SYN, which was carried out for eight weeks. Results showed a sign

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MESRIPOUR, Azadeh, and Pooya RAKHSHANKHAH. "A Synbiotic Mixture Ameliorates Depressive Behavior Induced by Dexamethasone or Water Avoidance Stress in a Mouse Model." Turkish Journal of Pharmaceutical Sciences 18, no. 1 (2021): 21–27. http://dx.doi.org/10.4274/tjps.galenos.2019.71300.

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MESRIPOUR, Azadeh, Andiya MESHKATI, and Valiollah HAJHASHEMI. "A Synbiotic Mixture Augmented the Efficacy of Doxepin, Venlafaxine, and Fluvoxamine in a Mouse Model of Depression." Turkish Journal of Pharmaceutical Sciences 17, no. 3 (2020): 293–98. http://dx.doi.org/10.4274/tjps.galenos.2019.94210.

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Krause, D. O., S. K. Bhandari, J. D. House, and C. M. Nyachoti. "Response of Nursery Pigs to a Synbiotic Preparation of Starch and an Anti-Escherichia coli K88 Probiotic." Applied and Environmental Microbiology 76, no. 24 (2010): 8192–200. http://dx.doi.org/10.1128/aem.01427-10.

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ABSTRACT Postweaning diarrhea in pigs is frequently caused by enterotoxigenic Escherichia coli K88 (ETEC). The aim of this study was to test the efficacy of E. coli probiotics (PRO) in young pigs challenged with E. coli K88. We also tested the synbiotic interaction with raw potato starch (RPS), which can be used as a prebiotic. Forty 17-day-old weaned piglets were randomly assigned to four treatments: treatment 1, positive-control diet (C), no probiotics or RPS but containing in-feed antibiotics; treatment 2, probiotic (PRO), no feed antibiotics plus a 50:50 mixture of probiotic E. coli strain

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