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Dissertations / Theses on the topic 'Syncytins'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Coquin, Youna. "Caractérisation de vecteurs lentiviraux pseudotypés par les syncytines murines et de leurs cibles cellulaires in vitro et in vivo." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLE039.

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Les vecteurs lentiviraux (LV) de thérapie génique sont des particules recombinantes qu'il est possible de pseudotyper avec diverses glycoprotéines d'enveloppe afin de modifier l'adressage cellulaire ou leurs propriétés immunogéniques. Mon travail de thèse a exploré l'hypothèse que la VSVG, la glycoprotéine d'enveloppe la plus utilisée pour pseudotyper les LV, puisse être remplacée par des protéines cellulaires afin d'obtenir des particules bien tolérées et administrables in vivo. J'ai utilisé les syncytines murines, qui sont des glycoprotéines d'origine rétrovirale endogène et qui ont des prop

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2

Funk, Mathis. "Identification et caractérisation de deux nouveaux gènes d'enveloppes rétrovirales de type syncytine, capturés pour un possible rôle dans la structure atypique du placenta de hyène et l'émergence du placenta non-mammifère des lézards Mabuya." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS106/document.

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Les syncytines sont des gènes d'enveloppes rétrovirales (env) capturés qui sont essentiels pour l'établissement du placenta chez les mammifères. Il a été proposé que la diversité des syncytines capturées explique pourquoi le placenta est l'organe le plus variable chez les mammifères. Ici nous avons employé deux approches pour étudier le lien entre la capture d'env et l'émergence et la diversité des structures placentaires. D'abord, nous avons étudié la placentation des Hyaenidae, les seuls carnivores à présenter un placenta très invasif hémochorial, comme l'humain. Comme tous les carnivores, l

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3

Carvalho, Lara. "The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1200566640735-93186.

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During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet of epithelial cells (EVL) and a yolk syncytial layer (YSL). Epiboly is characterized by the spreading of the blastoderm (deep cells and EVL) to cover the large yolk cell, whereas convergence and extension leads, respectively, to mediolateral narrowing and anteroposterior elongation of the embryo. Rece

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4

Carvalho, Lara. "The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish." Doctoral thesis, Technische Universität Dresden, 2007. https://tud.qucosa.de/id/qucosa%3A25041.

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During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet of epithelial cells (EVL) and a yolk syncytial layer (YSL). Epiboly is characterized by the spreading of the blastoderm (deep cells and EVL) to cover the large yolk cell, whereas convergence and extension leads, respectively, to mediolateral narrowing and anteroposterior elongation of the embryo. Rece

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5

Morgan, L. A. F. "Respiratory syncytial virus antigen immunoassay." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384012.

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6

Gimenez, Juliette. "Implication de la méthylation dans le contrôle de l'expression de rétrovirus endogènes humains en contextes physiologiques et pathologiques." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10222.

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Les rétrovirus endogènes (ERV) sont des éléments constitutifs de la plupart des génomes eucaryotes, et représentent chez l’humain environ 400000 loci. Les HERV sont divisés en familles distinctes, composées d’éléments apparentés mais structurellement hétérogènes. Leur activité peut être néfaste, neutre, mais aussi bénéfique. La majorité des HERV semble silencieuse dans les cellules somatiques. Cependant certains présentent une forte activité en contextes physiologiques. Par ailleurs, une expression significative de HERV est fréquemment observée dans des contextes pathologiques, tels que les ca

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7

Bataki, Efthalia Leah. "Inflammatory responses to respiratory syncytial virus." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251348.

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8

Matthews, Stephen Paul. "Immune mechanisms of respiratory syncytial virus disease." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406348.

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9

Spyer, Moira Jane. "Respiratory syncytial virus host cell receptor interactions." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269926.

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10

McNamara, Paul Stephen. "Cytokines in severe respiratory syncytial virus bronchiolitis." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400303.

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11

Hussain, Imran Raza. "The immunobiology of respiratory syncytial virus infection." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289569.

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12

Jones, Angela. "Human dendritic cell interactions with respiratory syncytial virus." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289663.

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13

Grieves, Jessica Louise. "Respiratory Syncytial Virus: Rodent Models and Vaccine Development." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354147313.

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14

Calvert, Sarah Joyce. "An investigation into the mechanisms of syncytial nuclear aggregate formation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/an-investigation-into-the-mechanisms-of-syncytial-nuclear-aggregate-formation(5654b3eb-72fe-4e86-ba7b-e0574c70c27e).html.

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The outer surface of the human placenta, the syncytiotrophoblast, results from the fusion of many cytotrophoblast cells such that many nuclei are contained in this layer. It is possible for these nuclei to cluster forming syncytial nuclear aggregates (SNAs). SNAs have been linked to pathology with increased numbers and earlier formation of SNAs in preeclampsia and fetal growth restriction (FGR). SNAs can be grouped into subtypes including bridges, knots and sprouts, dependent on morphology and attachment to surrounding placental villi. Little is known about SNA formation, but the pyknotic appe

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15

Xu, Chuang Connolly John Edward. "Respiratory syncytial virus subverts the immune response by inhibiting myeloid dendritic cell function." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5354.

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16

Tarter, Erin Elizabeth Jahnke. "Factors affecting repiratory syncytial virus positive wheezing illnesses in infants." Online version, 2002. http://www.uwstout.edu/lib/thesis/2002/2002tartere.pdf.

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17

Openshaw, Peter J. M. "Benefit and harm from immunity to respiratory syncytial virus." Thesis, Brunel University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238236.

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18

Munday, Diane Carolyn. "Analysis of human respiratory syncytial virus-host cell interactions." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634755.

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Human respiratory syncytial virus (HRSV) is the leading cause of serious lower respiratory tract disease in infants worldwide. Other high risk groups include the elderly and immunocompromised but HRSV can cause disease in all ages and infections recur throughout life. There is no approved vaccine available and costly antiviral therapies are inefficient for general use. HRSV infection therefore presents a significant healthcare and economic burden. The aims of this study were to investigate the HRSV-host cell interactions and examine the host response to infection via alterations to .the cellul

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19

Droniou, Magali Eliane. "Localisation of human respiratory syncytial virus proteins during infection." Thesis, University of Warwick, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487956.

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Human respiratory syncytial vilUs (hRSV) is an important pathogen causing respiratory disease, affecting predominantly the infant and elderly populations. No effective vaccine or anti-viral treatment is yet available against this virus. hRSV is a negative-sense, nonsegmented RNA virus, which encodes II proteins. The N, P, Land M2-1 proteins constitute the viral polymerase and the M2-2 protein acts as a regulatory element in the balance between transcription and replication. The G protein allows attachment of the virus to cellular glycosaminoglycans receptors, and the F protein mediates entry o

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20

Stevenson, Victoria A. "Actin Reorganization in Drosophila Syncytial Blastoderm Embryos: a Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/308.

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This work addresses the mechanism of cell cycle specific actin reorganization in Drosophila syncytial blastoderm embryos. During mitosis in typical animal cells after chromosome segregation is complete, daughter cells are separated in a process called cytokinesis. Cytokinesis is ordinarily driven by constriction of an actin ring that physically pinches the cell in two. The early Drosophila embryo is a syncytium; nuclei divide in a single cell without intervening cytokinesis. During the later syncytial divisions, nuclei are arranged in a monolayer at the cortex of the embryo. This stage of embr

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21

Slack, Mark Stuart. "Functional analysis of the phosphoprotein of respiratory syncytial virus." Thesis, University of Warwick, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322434.

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22

Weber, Martin Willi. "Infection with the respiratory syncytial virus in the Gambia." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262711.

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23

Lumb, Hayley Joy. "Probing protein-protein interactions from human respiratory syncytial virus." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12479/.

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Human respiratory syncytial virus (hRSV) is the leading cause of viral respiratory tract infections in children.1 In 2013 there were over 60 000 infants hospitalised in the USA alone and the virus resulted in approximately 2.1 million outpatient visits by children under 5 years old.2 The virus leaves the lungs weakened and open to further secondary infections such as bronchitis and pneumonia, especially in immunocompromised and elderly patients. Infections can lead to long-term effects and up to 70% of infants are left with respiratory problems for up to 10 years following hRSV bronchiolitis.3

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24

Currie, Silke Maria. "Antiviral function of LL-37 on respiratory syncytial virus." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25954.

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Recurrent infection with human respiratory syncytial virus (RSV) is one of the most common causes for lower respiratory tract illness (LRI) in infants, the elderly, and immunocompromised individuals. Due to lack of vaccines and therapeutic interventions, medical care of acute RSV bronchiolitis is mostly limited to supportive measures. Thus, novel treatment options to control RSV infection are desperately required. The cationic host defence peptide human cathelicidin LL-37 possesses both microbicidal and immunomodulatory properties. This essential effector of the innate immune system holds pote

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25

Werling, Dirk. "Interaction of bovine dendritic cells with respiratory syncytial virus." Thesis, Royal Veterinary College (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392913.

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26

Hayward, Daniel. "The spindle assembly pathways of the Drosophila syncytial embryo." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15700.

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The mitotic spindle is a key cellular structure responsible for aligning and separating chromosomes during mitosis. It is vital that this process is performed faithfully, as errors can result in disease causing genome instability. The mitotic spindle is primarily composed of an organised mass of dynamic microtubules that form a bipolar structure. Different cells have been shown to employ varying molecular pathways to generate these microtubules; however how these multiple pathways coexist and coordinate in a single cell type is poorly understood. Using the Drosophila syncytial embryo as a mode

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27

Sourimant, Julien. "Caractérisation structurale et fonctionnelle de la polymérase du virus respiratoire syncytial." Thesis, Versailles-St Quentin en Yvelines, 2015. http://www.theses.fr/2015VERS019V.

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Le virus respiratoire syncytial (VRS) est le principal agent responsable desbronchopneumonies du jeune veau et des bronchiolites du nourrisson. Il n’existe pas devaccin ni d’antiviraux spécifiques pour l’homme. La réplication du génome et la transcriptiondes gènes viraux sont assurées par un ensemble de protéines virales constituant le complexeARN polymérase ARN-dépendant : la nucléoprotéine N, la phosphoprotéine P, le facteur detranscription M2-1 et la grosse sous-unité L. L’objectif principal de ma thèse était d’obtenirde nouvelles données structurales et fonctionnelles sur le complexe ARN-p

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28

Fontaney, Laurence. "Devenir à moyen terme des enfants atteints d'une affection à virus respiratoire syncytial." Saint-Etienne, 1994. http://www.theses.fr/1994STET6211.

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29

Grandin, Clément. "Développement d'un modèle d'infection par le virus respiratoire syncytial humain chez le macaque cynomolgus pour l'évaluation de molécules antivirales candidates." Paris 7, 2014. http://www.theses.fr/2014PA077181.

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Le Virus Respiratoire Syncytial humain (hVRS) est en général responsable d'infections bénignes des voies respiratoires supérieures, mais il est également associé à des infections pulmonaires chez les nouveau-nés et les personnes âgées ou immunodéprimées. L'arsenal thérapeutique contre le hVRS est extrêmement limité. L'Unité de Génomique Virale et Vaccination de l'Institut Pasteur a isolé deux familles de composés chimiques capables d'inhiber la biosynthèse de novo des pyrimidines, présentant une puissante activité antivirale in vitro, et capables d'inhiber la réplication de nombreux virus à AD

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30

Cyr, Sonya L. "Novel intranasal proteosome-based respiratory syncytial virus (RSV) vaccines elicit protection in mice without the risk of enhanced pathology or eosinophila by triggering innate immune pathways." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111892.

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No safe and effective vaccine exists against respiratory syncytial virus (RSV), the main viral cause of lower respiratory tract infections in young children. Proteosome-based adjuvants, derived from the outer membrane proteins (OMP) of Neisseria species are potent inducers of mucosal and systemic immunity in humans and animals. RSV subunit vaccines based on enriched RSV proteins (eRSV) were formulated with proteosomes (Pro) or its S. flexneri LPS-supplemented derivative, Protollin (Prl). Administered intranasally (IN) in BALB/c mice, the vaccines elicited systemic and mucosal RSV-specific anti

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31

Soulestin, Marion Meyer Gilles. "Evaluation expérimentale de l'efficacité d'un candidat vaccin sous-unitaire contre le virus respiratoire syncytial bovin." [S.l.] : [s.n.], 2009. http://oatao.univ-toulouse.fr/3061/1/jan_3061.pdf.

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32

TOUAHMIA, BADREDDINE. "Les infections a virus respiratoire syncytial en pediatrie hospitalisees a clermont-ferrand d'octobre 1986 a mai 1987." Clermont-Ferrand 1, 1990. http://www.theses.fr/1990CLF13042.

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33

Welsh, Sarah Helen. "Mechanism of human respiratory syncytial virus (hRSV) resistance to palivizumab." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538924.

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34

Coleman, Christopher Michael. "Interactions Between Human Peripheral Blood Neutrophils and Respiratory Syncytial Virus." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500247.

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35

Wong, Terianne Maiko. "Innate Immune Responses to Respiratory Syncytial Virus: Age-associated Changes." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4854.

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Respiratory syncytial virus (RSV) infection causes ~64 million cases of respiratory disease and 200,000 deaths annually worldwide, yet there is no broadly effective prophylactic or treatment regimen. RSV can produce acute respiratory illness in patients of all ages but strikes the age extremes, infants and the elderly, with highest frequency presumably due to innate immune deficiencies. A higher morbidity and mortality has been reported for the elderly above 65 years of age, which has been attributed to immune senescence. Efforts to generate an effective vaccine have thus far been unsuccessful

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36

Robinson, John William. "Location of respiratory syncytial virus T and B cell epitopes." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334085.

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37

McGill, Alison Kate. "The role of antigenic variation in respiratory syncytial virus infection." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391959.

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38

Mekseepralard, Chantana. "Development of a potential therapeutic antibody against respiratory syncytial virus." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419700.

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39

SÌarmaÌ„, RaviÌ„ndra. "Immuno-pathogenesis of bovine respiratory syncytial virus infection in lambs." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316908.

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40

Forton, Julian. "Genetic susceptibility to severe respiratory syncytial virus bronchiolitis in infancy." Thesis, Open University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441153.

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41

King, Katherine Mary. "Modulation of respiratory syncytial virus immunopathology following gene gun vaccination." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445815.

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42

Gilca, Rodica. "Hospitalisations dues au virus respiratoire syncytial chez les jeunes enfants." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/25994/25994.pdf.

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43

Paradowski, Michael. "Spirooxindoles derivatives as novel inhibitors of the respiratory syncytial virus." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/71864/.

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44

Ait, Benhassou Hassan. "Protéases et défense immunitaire contre le virus respiratoire syncytial (VRS)." Reims, 2010. http://www.theses.fr/2010REIMP204.

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45

Skidmore, Faith Amanda. "Respiratory Syncytial Virus: the testing of a new candidate vaccine." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1409229956.

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46

Hart, Dirk. "Loop mediated isothermal amplification to detect respiratory syncytial virus in respiratory specimens." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96670.

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Thesis (MScMedSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Background: Respiratory Syncytial Virus (RSV) is the leading cause of severe lower respiratory tract infection in infants and children worldwide. Early diagnosis of RSV infection is associated with shorter periods of hospitalisation and decreased mortality. Current point of care (PoC) tests for RSV is less sensitive than molecular methods. Reverse transcription loop-mediated isothermal amplification (RT-LAMP), is a novel method of nucleic acid detection which allows for rapid, robust amplification, and visual detection

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47

MacLellan, Kirsty Marion. "Structural studies on the respiratory syncytial virus nucleocapsid and the phosphoprotein." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425259.

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48

Anderson, J. J. "The immune response to respiratory syncytial virus in an animal model." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380769.

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49

Hayes, Peter John. "The role of macrophages in respiratory syncytial virus infection of mice." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358972.

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50

Roy, Lilla MC. "Deriving health utility weights for infants with Respiratory Syncytial Virus (RSV)." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45030.

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