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Relevant bibliographies by topics / Syncytiotrophoblasts

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Academic literature on the topic 'Syncytiotrophoblasts'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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Journal articles on the topic "Syncytiotrophoblasts"

1

McConkey, Cameron A., Elizabeth Delorme-Axford, Cheryl A. Nickerson, et al. "A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance." Science Advances 2, no. 3 (2016): e1501462. http://dx.doi.org/10.1126/sciadv.1501462.

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In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface. Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of the human placenta, are directly bathed in maternal blood and are formed by the fusion of progenitor cytotrophoblasts that underlie them. Despite their crucial role in fetal protection, many of the events that govern trophoblast fusion and protection from microbial infection are unknown. We describe a three-dimensional (3D)–based culture model using human JEG-3 trophoblast cells that develop syncytiotrophobla

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Hemmings, D. G., R. Kilani, C. Nykiforuk, J. Preiksaitis, and L. J. Guilbert. "Permissive Cytomegalovirus Infection of Primary Villous Term and First Trimester Trophoblasts." Journal of Virology 72, no. 6 (1998): 4970–79. http://dx.doi.org/10.1128/jvi.72.6.4970-4979.1998.

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ABSTRACT Forty percent of women with primary cytomegalovirus (CMV) infections during pregnancy infect their fetuses with complications for the baby varying from mild to severe. How CMV crosses the syncytiotrophoblast, the barrier between maternal blood and fetal tissue in the villous placenta, is unknown. Virus may cross by infection of maternal cells that pass through physical breaches in the syncytiotrophoblast or by direct infection of the syncytiotrophoblast, with subsequent transmission to underlying fetal placental cells. In this study, we show that pure (>99.99%), long-term and healt

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H K, Sharath Kumar, Chaitra N, Nataraju G, and Bharathi M. "Immunohistochemical Study of VEGF in Placenta of Hypertensive Mothers." Annals of Pathology and Laboratory Medicine 7, no. 9 (2020): A474–477. http://dx.doi.org/10.21276/apalm.2834.

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Background: Pregnancy is most commonly complicated by Hypertensive disorders. In India, the incidence of gestational hypertension varies from 0.5-1.8%. VEGF is a prime regulator of angiogenesis and overall maintenance of endothelial cell health. This study aims to determine the role of VEGF in placentae of Hypertensive and Normotensive pregnancies by assessing its immunohistochemical expression in Syncytiotrophoblasts.  Methods: The study was conducted in the Department of Pathology in our institute. This is a case-control study which included 50 placentae. Out of which,25 were fro

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Longtine, Mark S., Silvija Cvitic, Bryanne N. Colvin, Baosheng Chen, Gernot Desoye, and D. Michael Nelson. "Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts." Reproduction 154, no. 6 (2017): 735–44. http://dx.doi.org/10.1530/rep-17-0183.

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We assessed the response of primary cultures of placental villous mononucleated trophoblasts and multinucleated syncytiotrophoblast to calcitriol, the most biologically active form of vitamin D. Whole-genome microarray data showed that calcitriol modulates the expression of many genes in trophoblasts within 6 hours of exposure and RT-qPCR revealed similar responses in cytotrophoblasts, syncytiotrophoblasts and villous explants. Both cytotrophoblasts and syncytiotrophoblasts expressed genes for the vitamin D receptor, for LRP2 and CUBN that mediate internalization of calcidiol, forCYP27B1that e

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Lacroux, C., F. Corbière, G. Tabouret, et al. "Dynamics and genetics of PrPSc placental accumulation in sheep." Journal of General Virology 88, no. 3 (2007): 1056–61. http://dx.doi.org/10.1099/vir.0.82218-0.

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Placentae from scrapie-affected ewes are an important source of contamination. This study confirmed that scrapie-incubating ewes bearing susceptible genotypes could produce both abnormal prion protein (PrPSc)-positive and -negative placentae, depending only on the PRP genotype of the fetus. The results also provided evidence indicating that scrapie-incubating ARR/VRQ ewes may be unable to accumulate prions in the placenta, whatever the genotype of their progeny. Multinucleated trophoblast cells appeared to play a key role in placental PrPSc accumulation. PrPSc accumulation began in syncytiotro

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Colvin, Bryanne N., Mark S. Longtine, Baosheng Chen, Maria Laura Costa, and D. Michael Nelson. "Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts." Reproduction 153, no. 4 (2017): 369–80. http://dx.doi.org/10.1530/rep-16-0576.

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Pre-pregnancy obesity is increasingly common and predisposes pregnant women and offspring to gestational diabetes, pre-eclampsia, fetal growth abnormalities and stillbirth. Obese women exhibit elevated levels of the two most common dietary fatty acids, palmitate and oleate, and the maternal blood containing these nutrients bathes the surface of trophoblasts of placental villi in vivo. We test the hypothesis that the composition and concentration of free fatty acids modulate viability and function of primary human villous trophoblasts in culture. We found that palmitate increases syncytiotropho

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Chen, Baosheng, Mark S. Longtine, Yoel Sadovsky, and D. Michael Nelson. "Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts." American Journal of Physiology-Cell Physiology 299, no. 5 (2010): C968—C976. http://dx.doi.org/10.1152/ajpcell.00154.2010.

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Hypoxia is commonly assigned a role in the placental dysfunction characteristic of preeclampsia and intrauterine growth restriction. We previously showed that hypoxia upregulates p53 and enhances apoptosis in primary cultures of human cytotrophoblasts. Here we tested the hypothesis that hypoxia also induces apoptosis in syncytiotrophoblasts by upregulation of p53. Primary cultures of human cytotrophoblasts that had differentiated into syncytiotrophoblasts by 52 h were exposed for ≤24 h to 20% or <1% oxygen in the presence or absence of staurosporine or the p53 modulators nutlin-3, pifithrin

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Wang, Ying, Baosheng Chen, Mark S. Longtine, and D. Michael Nelson. "Punicalagin promotes autophagy to protect primary human syncytiotrophoblasts from apoptosis." REPRODUCTION 151, no. 2 (2016): 97–104. http://dx.doi.org/10.1530/rep-15-0287.

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Punicalagin is a prominent polyphenol in pomegranate juice that protects cultured syncytiotrophoblasts from stress-induced apoptosis. Here, we test the hypothesis that punicalagin has this effect by inhibiting the mTOR kinase pathway to enhance autophagic turnover and limit apoptosis in cultured primary human syncytiotrophoblasts. In syncytiotrophoblasts, starvation, rapamycin, or punicalagin all decreased the expression of phosphorylated ribosomal protein S6, a downstream target of the mTOR kinase, and of the autophagy markers, LC3-II and p62. In contrast, in the presence of bafilomycin, an i

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Tuan, R. S., C. J. Moore, J. W. Brittingham, J. J. Kirwin, R. E. Akins, and M. Wong. "In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells." Journal of Cell Science 98, no. 3 (1991): 333–42. http://dx.doi.org/10.1242/jcs.98.3.333.

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During human fetal development, placental syncytiotrophoblasts actively transport calcium from the maternal to the fetal circulation. Two functional components, a cytosolic Ca2(+)-binding protein (CaBP) and a Ca2(+)-ATPase have been identified in the syncytiotrophoblasts of the chorionic villi. We report here the calcium uptake properties of a human choriocarcinoma cell line, JEG-3, which was used as an in vitro model cell system for the syncytiotrophoblasts. In culture, JEG-3 proliferated as large syncytial aggregates expressing typical syncytiotrophoblast markers. 45Ca uptake by JEG-3 was a

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Duello, T. M., P. J. Bertics, D. L. Fulgham, and P. J. Van Ess. "Localization of epidermal growth factor receptors in first- and third-trimester human placentas." Journal of Histochemistry & Cytochemistry 42, no. 7 (1994): 907–15. http://dx.doi.org/10.1177/42.7.8014474.

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Studies to date have demonstrated epidermal growth factor (EGF) receptors primarily on the outer plasma membrane of the human placental syncytiotrophoblasts facing maternal blood and to a lesser extent on the cytotrophoblast stem cells. In the present studies, first- and third-trimester human placental tissues were immunostained with monoclonal antibodies (MAb) to the EGF binding domain of the human EGF receptor or to the activated (tyrosine-phosphorylated) human EGF receptor. Cytotrophoblasts, syncytiotrophoblasts, and fetal connective tissue cells in first-trimester tissues immunostained wit

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Dissertations / Theses on the topic "Syncytiotrophoblasts"

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Reid, Neil A. "Molecular and cellular studies on placental glucose transport." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318590.

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Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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Kenton, Paul. "Studies of signalling pathways in human syncytiotrophoblast." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358992.

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Kumar, Surendran Sailesh. "Pre-eclampsia, shed membrane microparticles and syncytiotrophoblast apoptosis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365865.

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Knight, Marian. "Syncytiotrophoblast microvillous membrane deportation in the pathogenesis of pre-eclampsia." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389045.

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Carey, Julie. "NUMB and Syncytiotrophoblast Development and Function: Investigation Using BeWo Choriocarcinoma Cells." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22846.

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The role of NUMB, a protein important for cellular differentiation and endocytosis in non-placental cells, was investigated in syncytiotrophoblast development and function in the human placenta. The BeWo choriocarcinoma cell line was used as a model for villous cytotrophoblast cells and syncytiotrophoblast to investigate NUMB’s involvement in differentiation and epidermal growth factor receptor (EGFR) endocytosis. NUMB isoforms 1 and 3 were found to be the predominant isoforms and were upregulated following forskolin-induced differentiation. Overexpression of NUMB isoforms 1 and 3 did not medi

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Germain, Sarah. "The maternal inflammatory response and circulating syncytiotrophoblast microparticles in normal pregnancy and pre-eclampsia." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413085.

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Lofthouse, E. M. "The accumulation of glutamate in the placental syncytiotrophoblast as a driver of membrane transport." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/374566/.

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Gupta, Anurag Kumar. "Immune-modulation by the placenta and its dysregulation in preeclampsia : role of syncytiotrophoblast microparticles and cytokines /." Basel : [s.n.], 2005. http://edoc.unibas.ch/diss/DissB_7215.

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Haghighi, Poodeh S. (Saeid). "Novel pathomechanisms of intrauterine growth restriction in fetal alcohol syndrome in a mouse model." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526213163.

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Abstract Fetal alcohol syndrome (FAS) is a pattern of anomalies in affected children due to maternal alcohol administration at vulnerable stages of fetal development. Intrauterine growth restriction and facial malformation are the presenting phenotypes of FAS. In this investigation, novel pathomechanisms of intrauterine growth restriction and facial malformation were the primary aims. We found by a FAS mouse model that AceCS1 gene expression and polyamines are the immediate targets of fetal alcohol exposure. The AceCS1 product is a precursor for lipid synthesis and protein acetylation and poss

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Book chapters on the topic "Syncytiotrophoblasts"

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Kliman, Harvey J., Michael A. Feinman, and Jerome F. Strauss. "Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture." In Cellular Biology and Pharmacology of the Placenta. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-1936-9_29.

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Kenton, Paul, Paul D. Webb, Robert K. Lister, and Peter M. Johnson. "Does Human Syncytiotrophoblast Express the M-CSF Receptor/ C-fms Protein Product?" In Uterine and Embryonic Factors in Early Pregnancy. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3380-1_16.

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Quinn, G., A. Flynn, and B. Lonnerdal. "Saturable Zinc Uptake by Syncytiotrophoblast Microvillous Plasma Membrane Vesicles from Human Placenta." In Trace Elements in Man and Animals 6. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0723-5_146.

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Ay, Eva, Ferenc Banati, Katalin Turi-Balog, and Janos Minarovits. "The Role of Endogenous Retroviruses in the Formation of Syncytiotrophoblast and Materno-Fetal Barrier." In Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4216-1_3.

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Desforges, Michelle, Hannah Whittaker, Etaoin Farmer, Colin P. Sibley, and Susan L. Greenwood. "Effects of Taurine Depletion on Human Placental Syncytiotrophoblast Renewal and Susceptibility to Oxidative Stress." In Taurine 9. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15126-7_6.

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Kenton, Paul, Peter M. Johnson, and Paul D. Webb. "Phosphorylation of the Calcium-Binding Protein, p68, in the Submembranous Cytoskeleton of Human Placental Syncytiotrophoblast." In Advances in Experimental Medicine and Biology. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5754-4_23.

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Go, Attie T. J. J., Allerdien Visser, Marie Dijk, et al. "A Novel Method to Identify Syncytiotrophoblast-Derived RNA Products Representative of Trisomy 21 Placental RNA in Maternal Plasma." In Prenatal Diagnosis. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-066-9_23.

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Roberts, R. Michael, Shinichiro Yabe, Ying Yang, and Toshihiko Ezashi. "A Human Stem Cell Model for Creating Placental Syncytiotrophoblast, the Major Cellular Barrier that Limits Fetal Exposure to Xenobiotics." In Stem Cells in Toxicology and Medicine. John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781119135449.ch10.

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Ahart, Erin, Elaine Phillips, Michael Wolfe, and Courtney Marsh. "The Role of Kisspeptin in the Ovarian Cycle, Pregnancy, and Fertility." In Infertility and Assisted Reproduction [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98446.

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Kisspeptins are a group of neuropeptides with regulatory functions related to puberty, fertility, and reproduction. They are primarily produced by hypothalamic nuclei and are thought to regulate the activity of neurons that produce gonadotropin-releasing hormone. They are also expressed by placental syncytiotrophoblasts in developing pregnancies and are likely involved in the processes of trophoblast invasion and placentation. Similarly to beta-hCG, kisspeptins are found in maternal plasma during the first trimester of pregnancy and increase proportionately with gestational age. Because of their role in implantation, there is currently interest in the use of kisspeptins as minimally invasive biomarkers. It is suspected that maternal kisspeptin levels have diagnostic potential in identifying viable early pregnancies.

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"Urothelial Carcinoma with Syncytiotrophoblastic Giant Cells." In High-Yield Uropathology. Elsevier, 2012. http://dx.doi.org/10.1016/b978-1-4377-2523-0.00098-x.

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Conference papers on the topic "Syncytiotrophoblasts"

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Matsumoto, T., K. Kanamaru, Y. Sugiyama, and K. Deguchi. "HEMATOLOGICAL CHARACTERISTICS OF PREGNANT BLOOD AND LOCALIZATION OF THROMBOMODULIN IN HUMAN PLACENTAL VILLOUS TISSUE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644299.

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Thrombomodulin(TM) is a cell surface protein found on endothelial cell that binds thrombin and increases thrombin's ability to activate protein C(PC). In the present study, we examined hematological characteristics and behavior of plasma PC level in pregnant women and localization of TM in the placental villous tissue. The results obtained are reported here. Cubital venous blood of 20 normal pregnants, 8 purperants and 60 non-pregnants. PC antigen(PC:Ag) was measured by the Laurell's technique using Assera plate-proteinC. Localization of TM was determined in such a way that the villous tissue

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Sadler, J. Evan. "THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643930.

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Human von Willebrand factor (vWF) is a plasma glycoprotein that is synthesized by endothelial cells and megakaryocytes, and perhaps by syncytiotrophoblast of placenta. The biosynthesis of vWF is very complex, involving proteolytic processing, glycosyla-tion, disulfide bond formation, and sulfation. Mature vWF consists of a single subunit of ∼ 250,000 daltons that is assembled into multimer ranging from dimers to species of over 10 million daltons. vWF performs its essential hemostatic function through several binding interactions, forming a bridge between specific receptors on the platelet sur

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