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1

Sanfilippo, Joseph S. "Polycystic Ovarian Syndrome Since Stein and Leventhal." Journal of Pediatric and Adolescent Gynecology 28, no. 6 (December 2015): 411. http://dx.doi.org/10.1016/j.jpag.2015.10.001.

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2

Matevosyan, Naira R. "Schizophrenia and Stein–Leventhal syndrome: comorbidity features." Archives of Gynecology and Obstetrics 284, no. 4 (July 30, 2011): 1035–41. http://dx.doi.org/10.1007/s00404-011-1963-1.

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3

Kurzrock, Razelle, and Philip R. Cohen. "Polycystic ovary syndrome in men: Stein–Leventhal syndrome revisited." Medical Hypotheses 68, no. 3 (January 2007): 480–83. http://dx.doi.org/10.1016/j.mehy.2006.03.057.

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4

Edward, H., T. Cobb, and E. William. "Cognitive and affective symptoms in Stein-Leventhal syndrome." Archives of Clinical Neuropsychology 6, no. 3 (January 1, 1991): 192–93. http://dx.doi.org/10.1093/arclin/6.3.192a.

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5

Raboch, Jan, Jitka Kobilkov�, Ji?� Raboch, and Luboslav St�rka. "Sexual life of women with the Stein-Leventhal Syndrome." Archives of Sexual Behavior 14, no. 3 (June 1985): 263–70. http://dx.doi.org/10.1007/bf01542108.

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6

Singh, Richa, Poonam Yadav, and Roohi Parveen. "Adolescent Polycystic Ovary Syndrome: A Management Dilemma." Journal of South Asian Federation of Obstetrics and Gynaecology 4, no. 3 (2012): 123–25. http://dx.doi.org/10.5005/jp-journals-10006-1192.

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ABSTRACT Since the description by Stein and Leventhal the enigma of polycystic ovarian syndrome keeps on unfolding day by day. Recently due to changes in lifestyle the incidence of adolescent PCOS is on rise and form the basis of metabolic and endocrinological diseases in later life. Hence, it is of utmost importance to recognize the pathology at earliest and treat it before the features become resistant. How to cite this article Singh R, Yadav P, Parveen R. Adolescent Polycystic Ovary Syndrome: A Management Dilemma. J South Asian Feder Obst Gynae 2012;4(3):123-125.
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7

Kiryushkina, D. A. "From the history of polycystic ovary syndrome." Obstetrics, Gynecology and Reproduction 13, no. 3 (September 21, 2019): 261–64. http://dx.doi.org/10.17749/2313-7347.2019.13.3.261-264.

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Polycystic ovary syndrome (PCOS) is a gynecological disease manifested in polycystic ovarian morphology, oligo/ anovulation, hyperandrogenism, hirsutism, alopecia, and acne. PCOS affects 5–10 % of women of reproductive age. The first histological description of polycystic ovaries was made by Antonio Vallisneri. Then, Kronid Fedorovich Slavyanskiy, for the first time, described the clinical picture of PCOS, and Sergey Kuzmich Lesnoy proposed ovary wedge resection for surgical treatment. Irving Stein and Michael Leventhal studied the PCOS symptom complex and provided the recommendations on its diagnosis and treatment to restore normal menstrual cycle and fertility in such patients.
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8

Khankoev, IM, BI Kazakov, OA Magerlamov, and VN Pigarev. "Comparative evaluation of the effect of the combined treatment of stein-leventhal syndrome with high-level prolactin." Journal of the American Association of Gynecologic Laparoscopists 1, no. 4 (August 1994): S17. http://dx.doi.org/10.1016/s1074-3804(05)80923-5.

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9

Dey, Prabha. "Quality of life of women with polycystic ovarian syndrome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 7 (June 27, 2018): 2586. http://dx.doi.org/10.18203/2320-1770.ijrcog20182447.

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Background: Polycystic ovary syndrome (PCOS), also known as hyper androgenic anovolation (HA or Stein-Leventhal syndrome) is a well-recognised and common condition that causes considerable morbidity. The objective of the present study was to find out the quality of life of women with polycystic ovarian syndrome.Methods: Patients with PCOD diagnosed clinically at out patients department were selected for the study. SF 36 was applied to find out the Quality of life of women with polycystic ovarian syndrome.Results: A total of 84 patients were participated and 75% of the sample were student, 56.7% were graduate and 86.7% were non-vegetarian. The mean height of the sample was 155±4.81 centimeters. The mean weight of sample was 59.35±6.63 kgs and BMI mean was 24.70±3.47. Among 35% the duration of diagnosis was less than one year and for 65% it was more than one year. Means of the all sub set scores, across shorter and longer duration of being diagnosed as PCOD were significantly same on t test.Conclusions: Measured by SF 36, women with poly cystic ovarian disease/symptoms are suffering from significantly lowered quality of life, but independent of their duration of illness.
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10

Donesky, Barry W. "The role of laparoscopic ovarian electrocautery in the new millennium." Reproductive Medicine Review 7, no. 2 (July 1999): 111–29. http://dx.doi.org/10.1017/s0962279999000241.

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With the introduction of bilateral ovarian wedge resection (BOWR) in 1935, Stein and Leventhal were the first to describe an effective treatment for the chronic anovulation and associated infertility resulting from what was later to become known as polycystic ovary syndrome (PCOS). Since that time, many less invasive methods of ovulation induction and enhancement have been developed. While the success of medical ovulation induction led to the almost complete replacement of BOWR by the late 1970's, the presence of a group of women who are not optimally treated by medical methods has maintained the interest in surgical approaches. Surgical and nonsurgical methods of treatment for anovulatory women have continued to be refined. This manuscript reviews this literature and attempts to provide a framework for the role that modern surgical methods of ovulation induction might play in the current scheme of treatment for anovulatory infertility in women with PCOS.
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11

Kumari, Poonam, Poonam Choudhary, Sonu ., and Hetal H. Dave. "MANAGEMENT OF INFERTILITY DUE TO PCOS BY AYURVEDIC REGIME: A CASE REPORT." International Journal of Research in Ayurveda and Pharmacy 11, no. 5 (October 30, 2020): 31–35. http://dx.doi.org/10.7897/2277-4343.1105137.

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Polycystic ovarian Syndrome (PCOS) otherwise known as Stein Leventhal Syndrome is known to be the most common endocrine disorder in a woman of reproductive age and leading cause of infertility nowadays. World Health Organization (WHO) has estimated that there are one out of forty newly reported cases of PCOS worldwide. Here is case study of a 27 years old female patient residing in Jaipur who consulted in OPD of National Institute of Ayurveda (NIA) Jaipur on 10.05.2019 with the chief complaints of unable to conceive since 2 years, delayed and scanty menstruation since 11/2 year. The patient was having history of depression and had antidepressants for 1 year. Her Ultrasonography findings were suggestive of PCOS. Patient was treated with Brahmi Ghrita orally with milk for 3 cycles. Go Ghrita Matra Basti for 2 cycles with proper counselling before and during the treatment as patient was a K/C/O depression. Patient missed her periods on 20.09.2019 and did her UPT which was found to be positive. Adequate antenatal care with all necessary examinations and advises was given to her and she delivered a full-term female baby on 18.06.2020. From this case study it is concluded that Brahmi ghrita and Go Ghrita Matra Basti are effective in treating Infertility due to POCS.
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12

Anderson, Kristin E., Thomas A. Sellers, Ping-Ling Chen, Stephen S. Rich, Ching-Ping Hong, and Aaron R. Folsom. "Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa." Cancer 79, no. 3 (February 1, 1997): 494–99. http://dx.doi.org/10.1002/(sici)1097-0142(19970201)79:3<494::aid-cncr10>3.0.co;2-z.

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13

Parazzini, Fabio, Carlo La Vecchia, Silvia Franceschi, Renato Talamini, Eva Negri, and Pier Giorgio Crosignani. "Association of Stein-Leventhal Syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa." Cancer 80, no. 7 (October 1, 1997): 1357–62. http://dx.doi.org/10.1002/(sici)1097-0142(19971001)80:7<1360::aid-cncr28>3.0.co;2-4.

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14

Nagaria, Tripti, Arpita Mohapatra, and Jyoti Jaiswal. "Effect of Myoinositol and Metformin in combination on clinical and hormonal profile in patients of polycystic ovarian syndrome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 2 (January 25, 2019): 702. http://dx.doi.org/10.18203/2320-1770.ijrcog20190309.

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Background: Polycystic ovarian syndrome (PCOS) also known as hyperandrogenic anovulation syndrome or Stein – Leventhal syndrome is an endocrine disorder, characterized by anovulation, oligomenorrhea, amenorrhea, features of androgenic hormone excess (hirsutism, acne, alopecia, seborrhea) and insulin resistance. The global prevalence ranges from 2.2% to 26%. Methods: A prospective observational study was conducted from December 2015 to December 2016 in Department of Obstetrics and Gynecology at Pt. Jawahar Lal Nehru Memorial medical college and associated Dr. Bhim Rao Ambedkar memorial hospital, Raipur (C.G.) after obtaining permission of ethical committee of the institute to evaluate the effect of myoinositol and metformin on clinical profile in patients of polycystic ovarian syndrome. 70 women were included in the study who received a combination of myoinositol 600mg and metformin 500mg (twice a day) for 3 months for the management of PCOS. Prior to the start of the therapy, a detailed history and baseline investigations were recorded. Cases were reassessed at the end of three months of therapy for evaluation of change in clinical and hormonal profile.Results: 90.09% (63/70) cases showed improvement in the menstrual complaints. Spontaneous onset of menses occurred in all the cases presented with amenorrhea, in nearly 90% within 2 months of start of treatment. Regularization of cycles was observed in nearly 50% of patients with infrequent menses. Amongst all the cases with cutaneous manifestations, maximum improvement was seen in cases of acne (4/6) i.e. 66.66%. 25% (5/20) patients with infertility conceived during the study period.Conclusions: Myoinositol with metformin in combination has resulted in significant improvement in the clinical profile with reduction in individual drug dosage in cases with PCOS.
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15

Kirthika S., Veena, Jibi Paul, Senthil Selvam P., and Sathya Priya V. "Effect of progressive resisted exercises and aerobic exercises in the management of polycystic ovarian syndrome among young women- A pilot randomized controlled trial." Biomedicine 39, no. 4 (January 1, 2020): 608–12. http://dx.doi.org/10.51248/.v39i4.142.

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Introduction and Aim: Polycystic ovarian syndrome (PCOS) is a heterogenous, multisystem endocrinopathy in women of reproductive age also called as Stein Leventhal syndrome. PCOS is a common female endocrine disorder with prevalence ranging from 2.2% to 26%. Prevalence of PCOS in Indian adolescents is 9.13%. This draws attention to the issue of early diagnosis in adolescent girls. The aim of this study was to determine the effect of progressive resisted exercises (PRE) and aerobic exercises in the management of subjects with PCOS. Materials and Methods: This was an experimental comparative pre and post-test type study. The subjects in the age group of 18-25 years with the diagnosis of PCOS were selected based on Rotterdam criteria and with the BMI ranging between 25-29. Twenty four subjects were recruited and were randomly divided into two groups. group A was treated with PRE +aerobic exercises + diet and group B with aerobic exercises + diet. The duration of the study was 24 weeks and the outcome measures used were BMI, PCOSQ and hormonal levels (SHBG, Free testosterone, HOMA IR, Hs CRP) Results: The result of the study showed that group A treated with PRE + aerobic exercises + diet had significant improvement in BMI at P?0.05 and PCOSQ and specific hormonal levels at P?0.001 when compared to group B. Conclusion: A 24 weeks exercise intervention with a combined PRE +aerobic exercises +diet was superior to aerobic exercises +diet among young subjects with PCOS. Keywords: BMI; quality of life; PRE; PCOSQ; Hormones.
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16

Zoltán, Kun Imre, Kun Ildikó, and Kolcsár Melinda. "Current aspects of polycystic ovary syndrome I: definition, pathophysiology, clinical manifestations, diagnosis and complications." Bulletin of Medical Sciences 91, no. 1 (July 1, 2018): 5–18. http://dx.doi.org/10.2478/orvtudert-2018-0011.

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Abstract Polycystic ovary syndrome (PCOS) is the most frequent endocrine disease among women with childbearing potential, the best-known cause of hirsutism, with a hypothesized prevalence of 8-22%. The first part of the paper discusses the conceptional evolution of the syndrome, from its description in 1935 by Stein and Leventhal till today. It describes the changes in the criteria systems, emphasizing that the Rotterdam criteria, proposed in 2003 by the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine, are still valid today. This system basically differs from earlier (1990) NIH-criteria in one aspect: it introduced two newer phenotypes, one without hyperandrogenism and the other with ovulatory cycles, so it distinguishes 4 phenotypes. The etiology and pathogenesis of PCOS is heterogeneous, multifactorial, poorly understood. We present the 3 leading hypotheses (1 - hypothalamo-hypophyseal disturbances, 2 – primary enzyme disorders in ovarian, or ovarian/adrenal steroidogenesis, resulting primarily in hyperactivity of 17alpha-hydroxylase/17,20-lyase, 3 – insulin resistance-hyperinsulinism and other metabolic dysfunctions). We emphasize the role of genetically determined hyperandrogenism, that of insulin resistance-hyperinsulinism and the importance of reinforcing each other. Subsequently, the aggravating aspects of the frequently associated metabolic syndrome are discussed, and then the effects of the mentioned pathological processes on the endocrine and other organ structures participating in the regulation of sexual functions. We stress the hypothetical role of perinatal and pubertal androgen exposition in the pathogenesis of PCOS. The mechanisms of anovulation and those of the endometrial lesions are discussed, too. The clinical manifestations, the paraclinical and laboratory examinations, the positive and differential diagnosis and the complications are also presented. We intend to deal with the therapeutic aspects of PCOS in an upcoming paper.
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17

Ranwa, Monika, Tripti Nagaria, Jyoti Jaiswal, and Abhishek Arya. "Study of effect of myoinositol on menstrual irregularities and skin problems in polycystic ovarian syndrome cases." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 6 (May 25, 2017): 2310. http://dx.doi.org/10.18203/2320-1770.ijrcog20172120.

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Background: Polycystic ovary syndrome (PCOS), first identified in 1935 as Stein-Leventhal syndrome, is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women reproductive age. Typically PCOS is characterized by hyperandrogenism (extremely variable in its occurrence), chronic anovulation, polycystic ovaries at ultrasound evaluation and dermatological problems such as acne, hirsute and seborrhoea. PCOS is indeed the most common cause of female infertility.Methods: This prospective interventional study was conducted during December 2012 to June 2013 in Department of Obstetrics and Gynaecology at Pt. Jawaharlal Nehru Memorial Medical College and Associated Dr. Bhim Rao Ambedkar Memorial Hospital, Raipur (C.G.) India, after obtaining permission of ethical committee of institute. All young girls and married women who attended GOPD of Department of Obstetrics and Gynaecology having polycystic ovarian syndrome as defined by Rotterdam Criteria were registered and screened for inclusion in the study. At the end of three months’ data were compiled in MS-Excel and checked for its completeness and correctness then it was analysed suitable statistical test was applied and p-value <0.05 was considered statistically significant.Results: Maximum no of cases were between 21 to 25 yrs age, youngest one was of 15 yrs and oldest one was of 33 yrs. 72% cases belonged to urban area and only 28% cases belonged to rural area. 94.67% of cases were presented with abnormal menstrual cycle. The most common menstrual abnormality was Oligomenorrhoea (43.66%) followed by Oligomenorrhoea+Menorrhagia (21.13%) than Amenorrhoea (19.71%) and Hypomenorrhoea+Oligomenorrhoea (15.49%). 42.7% cases had oily skin, 26.7% cases had hirsutism, 20% cases had acne and 9.3% cases had acanthosis nigricans. 74.65% cases (53/75) were improved in their menstrual complaints; most common menstrual abnormality improved was Oligomenorrhoea+ Menorrhagia i.e. 88.67% (13/15). Out of all cases of oligomenorrhoea 77.4% cases (24/31) achieved regular menses. Out of all cases of oligomenorrhoea+ hypomenorrhoea 81.8%% cases (2/11) achieved regular menses.Conclusions: Present study confirms that Myoinositol, an insulin sensitizer, by improving insulin signalling reduces insulin resistance and improves menstrual irregularities and skin problems of PCOS cases.
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18

Maltseva, M. F., A. A. Pishchulin, and M. E. Bronstein. "Stromal ovarian tecomatosis." Problems of Endocrinology 42, no. 3 (June 15, 1996): 40–45. http://dx.doi.org/10.14341/probl12046.

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In 1942, S. Geist and J. Geines were the first to publish the unusual results of a histological examination of ovarian tissue in patients with Stein-Leventhal syndrome. They found foci of "luteinized" tecal cells, similar to theca interna folliculi cells, scattered along the ovarian "stroma" outside the follicles. The following year, L. Fraenkel in his work called these histopathological changes in ovarian hypertosis. In 1949, A. Culiner and S. Shipel used the term "hypertension syndrome" to refer to conditions in which foci of "tekomatosis", consisting of 10-30-60 individual hypertrophic and luteinized tecal cells in the ovarian "stroma", combined with the clinical picture of defemini ation and virilization. In subsequent years, due to the lack of a unified terminology in the literature, synonyms such as hypertosis, cortical stromal hyperplasia, stromal proliferation, stromal tecosis, and tecomatosis were used. R. Feinberg proposed dividing hypertosis into 3 groups, based on the predominance of cystic follicles and a thickened white membrane (mixed tecosis) with increased proliferation of the actual cells of the interstitial tissue or without it (internal tecosis). The presence of "stromal" proliferation in the absence of phenomena of cystic atresia of the follicles, he defined the term "stromal tecosis" (tekomatosis). I.V. Golubeva for the first time in our country drew attention to the clinical and hormonal features of stromal tecomatosis (ST), which was previously considered in the framework of polycystic ovary syndrome, and after 3 years M.E. Bronstein proved that this is an independent morphological form and gave a definition concepts of ST. Ovarian CT is understood as hyperplasia of the interstitial tissue of the ovaries and the appearance in it of groups of hypertrophied epithelioid cells that form foci of various sizes without any connection with follicles. The subject of this review is the consideration of the clinical and morphological picture of this disease, the features of hormonal homeostasis, modern hypotheses of the pathogenetic mechanisms of its development, as well as possible treatment options.
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19

Abdi, Amina. "Stein leventhal syndrome: a report of two cases." Endocrine Abstracts, May 8, 2018. http://dx.doi.org/10.1530/endoabs.56.ep97.

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20

"Cognitive and affective symptoms in Stein-Leventhal syndrome." Archives of Clinical Neuropsychology 6, no. 3 (1991): 192–93. http://dx.doi.org/10.1016/0887-6177(91)90064-g.

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21

Soni, Nirav R. "Current Management on PCOS (Polycystic Ovary Syndrome)/Stein-Leventhal Syndrome." Investigations in Gynecology Research & Womens Health (IGRWH) 1, no. 3 (November 14, 2017). http://dx.doi.org/10.31031/igrwh.2017.01.000511.

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22

R Soni, Nirav. "Epidemic Change-Current Traits on Stein-Leventhal Syndrome (SLS)." Current Trends in Biomedical Engineering & Biosciences 10, no. 4 (December 15, 2017). http://dx.doi.org/10.19080/ctbeb.2017.10.555794.

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23

A.Gadir, Mohammed A. Gafoor, Mohammed Omer Mohammed Hussein, and Mosab Nouraldein Mohammed Hamad. "Prevalence of polycystic ovarian syndrome among selected group of Sudanese housewives with infertility disorders." Asian Pacific Journal of Nursing and Health Sciences 2, no. 01 (June 30, 2019). http://dx.doi.org/10.46811/apjnh/2.1.4.

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Polycystic ovary syndrome (PCOS), also recognized as the Stein-Leventhal syndrome, is one of the most widespread endocrinopathies between women of reproductive age. Hyperinsulinemia in mixture with pancreatic beta cell dysfunction consequences in an increased risk of numerous illnesses, counting type 2 diabetes, hypertension, dyslipidemia, endothelial dysfunction, atherosclerosis and cardiovascular diseases. Insulin also stimulates the theca cells of the ovary to create excessive testosterone, which is accountable for the clinical symptoms of hyperandrogenism
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24

Rao, GVP. "Evaluation of Cardiovascular Disease Risk in Women having Poly Cystic Ovarian Syndrome." Journal of Cardiology and Cardiovascular Research, August 2, 2021. http://dx.doi.org/10.37191/mapsci-jccr-2(3)-036.

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PCOS, also known as Stein-Leventhal syndrome, is a common endocrine disease characterized by two of the following three characteristics: Once the associated endocrinological and gynecological diseases have been ruled out, oligo-ovulation or anovulation, ii) clinical and/or biochemical indications of hyperandrogenism, or iii) polycystic ovaries should be considered. Cardiovascular disease (CVD) risk factors are common in women with polycystic ovarian syndrome (PCOS). The Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society established a panel to offer evidence-based evaluations of research examining the PCOS-CVD risk connection and to produce CVD prevention recommendations. The main pathophysiological abnormality in polycystic ovarian syndrome is a source of much debate (PCOS). Chronic anovulation in conjunction with androgen excess, hyperinsulinemia, and changes in gonadotropin production are now widely accepted as symptoms of this disease in women. Polycystic ovarian syndrome (PCOS) is linked to obesity and low-grade inflammation, and it may raise the risk of cardiovascular disease (CVD). This study examines the assessment of cardiovascular disease risk in women with PCOS.
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25

Kanchan Choudhary, Ranjan Singh, Ajay Garg, Nitesh Verma, Anjali Purohit, and Deepika Deora. "AN UPDATED OVERVIEW OF POLYCYSTIC OVARY SYNDROME." Innovare Journal of Medical Sciences, June 10, 2019, 1–13. http://dx.doi.org/10.22159/ijms.2019.v7i3.34248.

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Polycystic ovary syndrome (PCOS), also known as Stein-Leventhal Syndrome, was first described in 1935. PCOS, which may also be referred to as polycystic ovary disease is the most common hormonal disorder found in premenopausal women. PCOS is the most common endocrine disorder in women of reproductive age and is the most common cause of infertility due to ovulation. A PCOS is an endocrine disorder which affects the adolescent girls. A PCOS is a condition in which a woman has an imbalance of female sex hormones. This may lead to changes in the menstrual cycle, cyst in the ovary, failure to conceive, and other health problems. It is a common health problem among teenagers and young women. It affects 5–10% of women in their reproductive years. These problems cause infertility. Two principal components to diagnose this syndrome are menstrual dysfunction and clinical or laboratory hyperandrogenism in which these items are used in clinical diagnosis. PCOS is a hormonal disorder that affects between 5% and 10% of women of reproductive age and remains the most enigmatic reproductive disorders. The most common symptoms of PCOS are obesity, acne, amenorrhea, irregular menstrual cycles, hirsutism, insulin resistance (IR), and high cholesterol. Due to the varied nature of PCOS and the large range of possible signs and symptoms, health personnel need a thorough knowledge of the disorder and its management. It is a major disorder characterized by elevated levels of male hormones (androgens), acne, and hirsutism. It can even cause IR, anovulation, and infertility on prolonging incidence of cysts. One of the treatments for PCOS is the use of synthetic medicine, which can help to treat PCOS but with side effects. However, many women who suffer from PCOS opt to use alternative medicine in conjunction with traditional medicine to improve their condition. There are some herbs that are very helpful in treating PCOS. Since PCOS is a curable disorder, it can be cured by the use of natural remedies or allopathic medication. There is a growing interest in herbal remedies or allopathic medication to cure the PCOS. There is a need to change the lifestyle management, diet to control the PCOS level. The natural remedies include treatment with phytoestrogenic and non-estrogenic herbs such as Licorice, Ginseng, Black cohosh, Dong, soy, evening primrose, honey, fenugreek, Schisandra root, and many other which are effective and safe. Many plants have been highly esteemed sources and have advantages which reduce PCOS and also having a hypoglycemic effect. In this review, an attempt has been made to study the use of natural remedy for the treatment of PCOS.
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