Relevant bibliographies by topics / Synergistic selection

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Synergistic selection'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Synergistic selection"

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Leimar, Olof, and Juha Tuomi. "Synergistic selection and graded traits." Evolutionary Ecology 12, no. 1 (1998): 59–71. http://dx.doi.org/10.1023/a:1006507023520.

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Tuomi, Juha, and Magnus Augner. "Synergistic Selection of Unpalatability in Plants." Evolution 47, no. 2 (1993): 668. http://dx.doi.org/10.2307/2410078.

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Tuomi, Juha, and Magnus Augner. "SYNERGISTIC SELECTION OF UNPALATABILITY IN PLANTS." Evolution 47, no. 2 (1993): 668–72. http://dx.doi.org/10.1111/j.1558-5646.1993.tb02120.x.

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Rosenberg, Gary. "Aposematism and Synergistic Selection in Marine Gastropods." Evolution 45, no. 2 (1991): 451. http://dx.doi.org/10.2307/2409681.

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Rosenberg, Gary. "APOSEMATISM AND SYNERGISTIC SELECTION IN MARINE GASTROPODS." Evolution 45, no. 2 (1991): 451–54. http://dx.doi.org/10.1111/j.1558-5646.1991.tb04421.x.

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Falconer, D. S. "Selection in different environments: effects on environmental sensitivity (reaction norm) and on mean performance." Genetical Research 56, no. 1 (1990): 57–70. http://dx.doi.org/10.1017/s0016672300028883.

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SummaryTo simplify the description of selection in two environments the terms ‘ antagonistic’ and ‘synergistic’ are used. Selection upwards in a bad environment or downwards in a good environment is antagonistic, the selection and the environment acting in opposite directions on the character. Synergistic selection is the reverse, upwards in a good environment or downwards in a bad, selection and environment acting in the same direction. Published experiments are reviewed to see how well they agree with two expectations. First, Jinks & Connolly (1973) showed that antagonistic selection reduces environmental sensitivity and synergistic selection increases it. The experiments reviewed showed many exceptions to this rule, but they all showed that sensitivity was less after antagonistic than after synergistic selection. This is shown to be simply the consequence of correlated responses being less than direct responses. Second, I suggested (Falconer, 1989) that antagonistic selection might be the best way to improve the mean performance in the two environments. In the experiments reviewed, antagonistic selection was significantly better than synergistic for changing the mean, but it is now shown that there is no theoretical justification for this expectation; if one type of selection is better in one direction the other ought to be better in the other direction.Expressions are given for the changes of mean performance and of sensitivity resulting from selection in one or other environment; these changes can be predicted from the parameters of the base population. In the experiments reviewed, an increase of mean performance accounted for 49% or more of the upward response. Equations are presented which allow the variance of mean performance, the variance of sensitivity, and the covariance of mean with sensitivity to be derived from parameters estimated in an unselected population, namely the variances in the two environments and the corresponding covariance. The variance of sensitivity that might be ascribed to scale effects is deduced. Directional selection in a single macro-environment is synergistic with respect to the micro-environmental differences, and is expected to increase environmental sensitivity and consequently to increase environmental variance. Stabilizing selection is antagonistic selection in both directions at the same time, and so is expected to decrease environmental variance.
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Kondrashov, A. S. "Muller's ratchet under epistatic selection." Genetics 136, no. 4 (1994): 1469–73. http://dx.doi.org/10.1093/genetics/136.4.1469.

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Abstract In a finite asexual population mean fitness may decrease by a process known as Muller's ratchet, which proceeds if all individuals with the minimum number of deleterious alleles are randomly lost. If these alleles have independent effects on fitness, previous analysis suggested that the rate of this decrease either remains constant or, if accumulation of mutations leads to the decline of the population size, grows. Here I show that this conclusion is quite sensitive to the assumption of independence. If deleterious alleles have synergistic fitness effects, then, as the ratchet advances, the frequency of the best available genotype will necessarily increase, making its loss less and less probable. As a result, sufficiently strong synergistic epistasis can effectively halt the action of Muller's ratchet. Instead of being driven extinct, a finite asexual population could then survive practically indefinitely, although with lower mean fitness than without random drift.
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Corning, Peter A., and Eörs Szathmáry. "“Synergistic selection”: A Darwinian frame for the evolution of complexity." Journal of Theoretical Biology 371 (April 2015): 45–58. http://dx.doi.org/10.1016/j.jtbi.2015.02.002.

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Boughman, Janette W., and Richard Svanbäck. "Synergistic selection between ecological niche and mate preference primes diversification." Evolution 71, no. 1 (2016): 6–22. http://dx.doi.org/10.1111/evo.13089.

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Sohail, Mashaal, Olga A. Vakhrusheva, Jae Hoon Sul, et al. "Negative selection in humans and fruit flies involves synergistic epistasis." Science 356, no. 6337 (2017): 539–42. http://dx.doi.org/10.1126/science.aah5238.

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Dissertations / Theses on the topic "Synergistic selection"

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Davidowitz, Goggy, Derek Roff, and H. Frederik Nijhout. "Synergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution." UNIV CHICAGO PRESS, 2016. http://hdl.handle.net/10150/622053.

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Natural selection acts on multiple traits simultaneously. How mechanisms underlying such traits enable or constrain their response to simultaneous selection is poorly understood. We show how antagonism and synergism among three traits at the developmental level enable or constrain evolutionary change in response to simultaneous selection on two focal traits at the phenotypic level. After 10 generations of 25% simultaneous directional selection on all four combinations of body size and development time in Manduca sexta (Sphingidae), the changes in the three developmental traits predict 93% of the response of development time and 100% of the response of body size. When the two focal traits were under synergistic selection, the response to simultaneous selection was enabled by juvenile hormone and ecdysteroids and constrained by growth rate. When the two focal traits were under antagonistic selection, the response to selection was due primarily to change in growth rate and constrained by the two hormonal traits. The approach used here reduces the complexity of the developmental and endocrine mechanisms to three proxy traits. This generates explicit predictions for the evolutionary response to selection that are based on biologically informed mechanisms. This approach has broad applicability to a diverse range of taxa, including algae, plants, amphibians, mammals, and insects.
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Zetuny, Yonatan. "A synergistic reputation-policy based trust model for Grid resource selection." Thesis, University of Westminster, 2011. https://westminsterresearch.westminster.ac.uk/item/90120/a-synergistic-reputation-policy-based-trust-model-for-grid-resource-selection.

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In the context of Grid computing, reputation-based trust management systems are playing an increasingly important role for supporting coordinated resource sharing and ensuring provision of quality of service. However, the existing Grid reputation-based trust management systems are considered limited as they are bounded to esoteric reputation-based trust models encompassing predefined metrics for calculating and selecting trusted computing resources and as a result, they prevent external involvement in the trust and reputation evaluation processes. This thesis suggests an alternative approach for reputation modelling founded on its core argument proclaiming that reputation is a subjective matter as well as context dependent. Consequently, it offers a synergistic reputation-policy based trust model for Grid resource selection. This exoteric trust model introduces a novel paradigm for evaluating Grid resources, in which Grid client applications (e.g. monitoring toolkits and resource brokers) are endeavoured to carry out an active participation in the trust and reputation evaluation processes. This is achieved by augmenting the standard reputation queries with a set of reputation-policy assertions constituting as complete trust metrics supplied into the reputation algorithm. Consecutively, the Grid Reputation-Policy Trust management system (GREPTrust) provides a concrete implementation for the trust model and it’s underlying artifacts whilst the GREPTrust testbed provides an adequate infrastructure for comparing the reputationpolicy trust model with a production available esoteric model (GridPP). Based on a computational finance case study, an internal workflow simulation utilises the GREPTrust testbed in order to empirically assess the criteria by which the synergistic reputation-policy based trust model outperforms esoteric trust models regarding resource selection and consequently provides substantive evidence that the reputation-policy paradigm is a welcome addition to the Grid computing community.
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Ren, Hao [Verfasser]. "Selection, Preparation and Application of Hostderived Probiotic Lactobacilli from Chicken and their Synergistic Effects with Phytobiotics on Broilers / Hao Ren." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1214241360/34.

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Carballo, Arce Ana F. "Phytochemical Investigations of Costa Rican Marcgraviaceae and Development of Insecticide Synergists." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30315.

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Substances of natural and synthetic origin were studied using analytical, bioassay guided isolation, metabolomics and medicinal chemistry techniques. In a section focused on the plant family Marcgraviaceae, a validated method for the quantification of six pentacyclic triterpenes (α and β Amyrin lupeol, ursolic acid, betulin and betulinic acid) in the Souroubea spp was developed. Quantification of the triterpenes in the crude extracts was achieved using HPLC-APCI mass selective detection. The calibration curves for the five triterpenes evaluated were highly linear (r2 >0.993) and percentage recovery from spiked samples were greater than 94% for all compounds. The LOD for betulinic acid was 0.01 µg for betulinic acid on column and LOQ was 0.03 µg. The method was successfully applied to 41 crude extracts from leaf and stem of Souroubea spp, from two locations in Costa Rica. The method is suitable for quality control of raw materials used in the manufacture of natural health products. The use of modern metabolomic techniques, UHPLC-QTOF allowed the identification of five putative makers that can potentially be used in distinguishing between the two Souroubea species. The validated method was used in the quantification of the above triterpenes in a total of thirteen Marcgraviaceae species collected in Costa Rica. It was established that betulinic acid and β- Amyrin could be used as makers for this family of tropical vines. These same thirteen plants extracts were evaluated in antifungal and quorum sensing inhibition bioassays. Marcgravia nervosa was the only species that showed significant activity in both bioassays. Bioassay guided fractionation of the crude ethanolic extract of M. nervosa led to the identification of 2-methoxynaphthoquinone as the bioactive compound responsible for the bioactivity. The crude leaf ethanolic extract from M. nervosa showed a significant inhibition of QS comparable or somewhat better than D. pulchra extracts with the M. nervosa extract showing stronger inhibiting QS with a halo of 21.8mm, more than D. pulcra extracts which generated a halo of 15.9mm. The active quinone has a MIC of 85 µM against Saccharomyces cerevisiaBY4741 (haploid) and 100 µM against Saccharomyces cerevisiae BY4743 (diploid) compared to berberine (positive control) with a MIC 600 µM for both strains. This quinone is not present in any of the other twelve species of Marcgraviaceae available to us. In work focusing on organic synthesis, a total of 57 semi-synthetic derivatives of dillapiol, safrol and piperonal were prepared and evaluated for their inhibitory activity in a CYP 3A4 bioassay to assess their potential use as pesticide synergists. The synergistic activity of dillapiol has been improved 45 fold; analog 31 has an IC50 = 0.2 µM compared with dillapiol IC50= 9.18 µM. A number of other compounds structurally related to 31 showed similar levels of activity. A screening of a compound library identified the amino sulfoxide 3 as a potential lead for the design of a selective connexin blocker with potential application in the treatment of spinal cord injuries. The use of X-ray crystallography permitted the correction of the original structure assigned to 3. Once the structure was corrected a total of 6 analogs were prepared. Compound 3 has the highest inhibition of GJIC whereas compound 8 and compound 2, reduced anionic hemi-channel activity. Compound 2 also reduced the cationic activity of the hemi-channels.
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"Directed selection and characterization of high-affinity synergistic antibodies." Tulane University, 2007.

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Antibody selection strategies can be devised to select antibodies that bind to specific epitopes, to proteins with unusual reaction kinetics or to particular protein conformations. In this work we initially validated a previously designed selection strategy to isolate an antibody with a fast on-rate. The success of this selection strategy was verified by measuring the bimolecular association rate constants of the newly selected antibody for two mouse IgG molecules already available in the Blake Laboratory A selection strategy was then designed to select for pairs of monoclonal antibodies that bound with synergy to their target antigen. A hybridoma library was created from the splenocytes of mice immunized with human IgA and screened for monoclonal antibodies that bound to human IgA. A secondary screen permitted the identification of antibody pairs that bound to distinct epitopes on the antigen. One of these pairs (14A7 and 5F5) was chosen for further studies to verify that this pair did exhibit the desired synergistic binding characteristics The equilibrium dissociation constants were measured for the independent binding of 5F5 and 14A7 to human IgA; these Kds were 0.17 nM and 555 nM, respectively. By taking advantage of the >3,000-fold difference in the affinity of 5F5 and 14A7 for IgA, experiments were designed whereby the 14A7 antibody was allowed to interact almost exclusively with the 5F5-IgA complex. Under these conditions, 14A7 bound with 8-fold higher affinity to the complex than to free IgA. It was therefore concluded that a pair of antibodies that bound with synergy to the target antigen had been successfully selected using this novel strategy<br>acase@tulane.edu
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"High-Throughput Platforms for Tumor Dormancy-Relapse and Biomolecule Binding Using Aminoglycoside-Derived Hydrogels." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.38425.

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abstract: Relapse after tumor dormancy is one of the leading causes of cancer recurrence that ultimately leads to patient mortality. Upon relapse, cancer manifests as metastases that are linked to almost 90% cancer related deaths. Capture of the dormant and relapsed tumor phenotypes in high-throughput will allow for rapid targeted drug discovery, development and validation. Ablation of dormant cancer will not only completely remove the cancer disease, but also will prevent any future recurrence. A novel hydrogel, Amikagel, was developed by crosslinking of aminoglycoside amikacin with a polyethylene glycol crosslinker. Aminoglycosides contain abundant amount of easily conjugable groups such as amino and hydroxyl moieties that were crosslinked to generate the hydrogel. Cancer cells formed 3D spheroidal structures that underwent near complete dormancy on Amikagel high-throughput drug discovery platform. Due to their dormant status, conventional anticancer drugs such as mitoxantrone and docetaxel that target the actively dividing tumor phenotype were found to be ineffective. Hypothesis driven rational drug discovery approaches were used to identify novel pathways that could sensitize dormant cancer cells to death. Strategies were used to further accelerate the dormant cancer cell death to save time required for the therapeutic outcome. Amikagel’s properties were chemo-mechanically tunable and directly impacted the outcome of tumor dormancy or relapse. Exposure of dormant spheroids to weakly stiff and adhesive formulation of Amikagel resulted in significant relapse, mimicking the response to changes in extracellular matrix around dormant tumors. Relapsed cells showed significant differences in their metastatic potential compared to the cells that remained dormant after the induction of relapse. Further, the dissertation discusses the use of Amikagels as novel pDNA binding resins in microbead and monolithic formats for potential use in chromatographic purifications. High abundance of amino groups allowed their utilization as novel anion-exchange pDNA binding resins. This dissertation discusses Amikagel formulations for pDNA binding, metastatic cancer cell separation and novel drug discovery against tumor dormancy and relapse.<br>Dissertation/Thesis<br>Doctoral Dissertation Bioengineering 2016
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Yang, Kai-Yu, and 楊鎧輿. "Synergistic catalysis of reversed micelles-synthesized Cu/samaria-doped ceria catalyst in selective CO oxidation." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04620927597093590816.

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碩士<br>義守大學<br>生物技術與化學工程研究所碩士班<br>99<br>Copper oxide impregnated on samaria-doped ceria (SDC) prepared by reverse microemulsion was empolyed as catalyst for the selective CO oxidation in a hydrogen-rich environment. Activity tests, as well as H2-temperature programmed reduction (H2-TPR), were carried out to investigate the behavior of the catalysts thus prepared, and compared with those made by co-precipitation. It has been found that the best performance can be obtained with 2 mol% of Sm doping. Activity results showed that for Cu/2SDC, CO oxidation picked up considerably at 60℃ and reached almost 100% conversion at 100℃ due to higher reactivity of CO toward interfacial oxygen ions, while at the latter temperature the hydrogen consumption increased to some extent, which related well with the occurrence of α peak temperature in H2-TPR. In addition, the competitive oxidation of CO and H2 were carried out at 120℃, showing that CO exhibits a higher oxidation activity and the active sites of the catalyst are apt to be occupied by CO thus limiting the accessibility of hydrogen to oxygen. These results demonstrate that the catalysts studied in this work exhibit superior selectivity in CO oxidation in rich hydrogen, without appreciable hydrogen consumption at 150℃.
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Recknor, Jennifer Behr. "Directed growth and selective differentiation of neural progenitor cells using a synergistic combination of topographical and soluble cues /." 2006.

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Books on the topic "Synergistic selection"

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Trestman, Robert L. Transition of pharmacology from community to corrections. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199360574.003.0019.

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Psychopharmacology in general is a challenging field that includes much art as well as science. Clinicians usually depend upon self-report in making decisions regarding medication selection and dosing. When a patient becomes incarcerated, there are multiple potentially conflicting, or synergistic, situations. There are issues of different formularies, different environmental stressors, changed support groups, and practice patterns that all may contribute differentially to medication management decisions. Current community medications may have been determined while ongoing illicit drug use confounded the diagnostic picture. Collaboration between clinician and patient may have been poor, and subsequently treatment adherence may in turn have been marginal. Many similar issues apply when a patient transfers from a jail to a prison or from one prison to another. Preparation and review of transfer summary sheets and more detailed records are just as important in these situations and should be seen as the minimum standard in policy and in practice. Ideally, continuity of care, and any concerns about diagnosis or treatment are best shared through direct communication. A telephone exchange between treating psychiatrists is always better than simple written documentation. This chapter discusses both the issues and pragmatic management opportunities that can lead to improved patient care and enhanced functioning.
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Book chapters on the topic "Synergistic selection"

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Taves, Donald R. "Flexible Minimization: Synergistic Solution for Selection Bias." In Randomization, Masking, and Allocation Concealment. Chapman and Hall/CRC, 2017. http://dx.doi.org/10.1201/9781315305110-15.

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Kuo, Ting. "A Synergistic Selection Strategy in the Genetic Algorithms." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11903697_53.

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Corning, Peter A. "Synergistic Selection: A Bioeconomic Approach to Complexity in Evolution." In Evolution, Development and Complexity. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-00075-2_14.

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Tang, Jin, Chundong Guo, and Shiwen Zhao. "Research on Synergistic Selection Decision-Making of Manufacturing Enterprises and the Third Party Logistics in the Cluster Environment." In Intelligent Computing Methodologies. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_44.

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Requintina, P. J., G. F. Oxenkrug, A. Yuwiler, and A. G. Oxenkrug. "Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs." In Amine Oxidases: Function and Dysfunction. Springer Vienna, 1994. http://dx.doi.org/10.1007/978-3-7091-9324-2_19.

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Tian, Xiangmiao, Yufeng Wu, Xiaofei Yin, Yu Gong, Kaihua Zhang, and Yu Fu. "Eco-friendly Selective Synergistic Extraction Rare-Earths from Waste CRT Phosphor Powder Sulfuric Acid Leachate with Imidazolium-Based Ionic Liquid [OMIm] [PF6] and Extractant Cyanex272." In Springer Proceedings in Energy. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0158-2_52.

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"Explaining Complexity." In Synergistic Selection. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/9789813230941_0001.

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"A New View of Evolution." In Synergistic Selection. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/9789813230941_0002.

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"How Cooperation Trumps Competition." In Synergistic Selection. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/9789813230941_0003.

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"Evolution as a “Combination of Labor”." In Synergistic Selection. WORLD SCIENTIFIC, 2018. http://dx.doi.org/10.1142/9789813230941_0004.

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Conference papers on the topic "Synergistic selection"

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Karwaczynski, Piotr. "Fabric: Synergistic Proximity Neighbour Selection Method." In 2007 7th International Conference on Peer-to-Peer Computing. IEEE, 2007. http://dx.doi.org/10.1109/p2p.2007.13.

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Karwaczynski, Piotr. "Fabric: Synergistic Proximity Neighbour Selection Method." In Seventh IEEE International Conference on Peer-to-Peer Computing (P2P 2007). IEEE, 2007. http://dx.doi.org/10.1109/p2p.2007.4343484.

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Anders, Anjali P., Lisa M. Rogers, and David M. Aronoff. "Macrophage-decidual Cell Co-culture Promotes a Synergistic Inflammatory Response to Lipopolysaccharide." In Selection of Abstracts From NCE 2016. American Academy of Pediatrics, 2018. http://dx.doi.org/10.1542/peds.141.1_meetingabstract.575.

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Rompokos, Pavlos, Andrew Rolt, Devaiah Nalianda, et al. "Synergistic Technology Combinations for Future Commercial Aircraft Using Liquid Hydrogen." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-15694.

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Abstract Liquid hydrogen (LH2) has long been seen as a technically feasible fuel for a fully sustainable greener aviation future. The low density of the cryogenic fuel would dictate the redesign of commercial aircraft to accommodate the large tanks, which are unlikely to be integrated within the whole internal volume of the wing. In the ENABLEH2 project, the morphological aspects of a LH2 aircraft design are discussed and a methodology for rapid concept comparative assessment is proposed. An exercise is then carried on to down-select short-to-medium range (SMR) and long-range (LR) concepts, able to carry 200 passengers for 3000 nmi and 414 passengers for 7500 nmi respectively. The down-selection process was split into two phases with the first considering 31 potential airframe architectures and 21 propulsion-system arrangements. The second phase made the final down-selections from a short-list of nine integrated design concepts that were ranked according to 34 criteria, relating to operating cost, revenue, noise and safety. Upon completion of the process, a tube and wing design with the tanks integrated into extended wing roots, and a blended-wing-body design were selected as the best candidates for the SMR and LR applications respectively. Both concepts feature distributed propulsion to maximise synergies from integrating the airframe and propulsion systems.
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Spadaccini, Louis J., David R. Sobel, and He Huang. "Deposit Formation and Mitigation in Aircraft Fuels." In ASME 1999 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/99-gt-217.

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The development of a viable strategy for limiting coke deposition involves combining synergistic approaches for suppressing deposit buildup and reducing its impact on performance. Candidate approaches, including selection of favorable operating conditions (viz., pressure, temperature, heat flux, residence time and passage size) and coke-tolerant heat exchanger designs, were investigated to evaluate their effectiveness and provide a basis for combining them into a single design philosophy. These approaches were evaluated through testing of current jet fuels in single-tubes and segments of heat exchanger configurations at temperatures up to 1000 F, pressures up to 1200 psi and liquid hourly space velocities up to 40,000/h. A key result of this work is the ranking of the importance of heat exchanger operating conditions on carbon deposition, with fuel temperature and those parameters that control species diffusion having the most pronounced impact. Residence time and pressure are of lesser importance. Alternative coke-tolerant heat exchanger designs featuring inter-channel communication were evaluated and ranked, with several of these concepts demonstrating improvement over continuous passages.
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Chowdhury, Souma, Jie Zhang, Achille Messac, and Luciano Castillo. "Developing a Flexible Platform for Optimal Engineering Design of Commercial Wind Farms." In ASME 2011 5th International Conference on Energy Sustainability. ASMEDC, 2011. http://dx.doi.org/10.1115/es2011-54503.

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In this paper, we develop a flexible design platform to account for the influences of key factors in optimal planning of commercial scale wind farms. The Unrestricted Wind Farm Layout Optimization (UWFLO) methodology, which avoids limiting assumptions regarding the farm layout and the selection of turbines, is used to develop this design platform. This paper presents critical advancements to the UWFLO methodology to allow the synergistic consideration of (i) the farm layout, (ii) the types of commercial turbines to be installed, and (iii) the expected annual distribution of wind conditions at a particular site. We use a recently developed Kernel Density Estimation (KDE) based method to characterize the multivariate distribution of wind speed and wind direction. Optimization is performed using an advanced mixed discrete Particle Swarm Optimization algorithm. We also implement a high fidelity wind farm cost model that is developed using a Radial Basis Function (RBF) based response surface. The new optimal farm planning platform is applied to design a 25-turbine wind farm at a North Dakota site. We found that the optimal layout is significantly sensitive to the annual variation in wind conditions. Allowing the turbine-types to be selected during optimization was observed to improve the annual energy production by 49% compared to layout optimization alone.
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Li, Ye, and Ragha Rapthadu. "Bending-Additive-Machining Hybrid Manufacturing of Sheet Metal Structures." In ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/msec2017-3062.

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The ever-increasing industry innovation demands a paradigm of manufacturing process that is capable of accomplishing multiple tasks on a single component. Majority of structural parts require bending of metal sheets with high degree of accuracy. In many applications bent parts with additional features are sought out for various special purposes. Clearly there is a need calling for the integration of different manufacturing processes to reach a synergistic effect [4, 5]. Traditionally a combination of additive manufacturing and machining is used to alleviate the constraints set forth by machining alone. However this hybrid approach is still constrained by both the limited cutter accessibility and gravity-imposed deposition direction. This paper presents a new Hybrid Manufacturing configuration by combining bending, deposition and machining processes. The major advantage of this new approach hinges on the deliberate use of bending process by providing additional accessibility that is not available on traditional additive – machining setup. Essentially the accessibility issue is overcome by introducing an intermediate bending step so that both metal deposition and removal can be conducted in the process-required orientation. As bending is part of this new hybrid process, springback is also inherent to this new hybrid manufacturing approach. This research incorporates the consideration of both springback compensation and cold hardening effect in the selection of intermediate bending step. Examples are also provided to show the efficacy of this new hybrid manufacturing approach.
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Hsu, Po-Chun. "Ultra-wideband tunable plasmonic selective absorber for dynamic synergistic solar and thermal energy conversion." In Active Photonic Platforms XIII, edited by Ganapathi S. Subramania and Stavroula Foteinopoulou. SPIE, 2021. http://dx.doi.org/10.1117/12.2594981.

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Park, Jinhwi, Ho-Woong Kang, Hyun-Mo Koo, et al. "Abstract 3915: YH25248, a selective PI3K delta inhibitor, shows synergistic effect with an anti-PD-L1 antibody." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3915.

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Park, Jinhwi, Ho-Woong Kang, Hyun-Mo Koo, et al. "Abstract 3915: YH25248, a selective PI3K delta inhibitor, shows synergistic effect with an anti-PD-L1 antibody." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3915.

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