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Journal articles on the topic 'Syntax score'

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Published: 4 June 2021

Last updated: 19 June 2025

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Farooq, Vasim, Salvatore Brugaletta, and Patrick W. Serruys. "The SYNTAX Score and SYNTAX-Based Clinical Risk Scores." Seminars in Thoracic and Cardiovascular Surgery 23, no. 2 (2011): 99–105. http://dx.doi.org/10.1053/j.semtcvs.2011.08.001.

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Yang, Chia-Hung, Ming-Jer Hsieh, Chun-Chi Chen, et al. "SYNTAX score." Coronary Artery Disease 23, no. 7 (2012): 445–49. http://dx.doi.org/10.1097/mca.0b013e3283587835.

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Tajik, Parvin, Katrien Oude Rengerink, Ben Willem Mol, and Patrick M. Bossuyt. "SYNTAX score II." Lancet 381, no. 9881 (2013): 1899. http://dx.doi.org/10.1016/s0140-6736(13)61151-4.

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Papadopoulou, Stella-Lida, Chrysafios Girasis, Anoeshka Dharampal, et al. "CT-SYNTAX Score." JACC: Cardiovascular Imaging 6, no. 3 (2013): 413–15. http://dx.doi.org/10.1016/j.jcmg.2012.09.013.

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Islam, Md Shariful, Md Afzalur Rahman, Abdul Wadud Chowdhury, et al. "SYNTAX Score on Procedural Outcome among Patient Undergoing Primary Percutaneous Coronary Intervention." Bangladesh Heart Journal 34, no. 1 (2019): 5–10. http://dx.doi.org/10.3329/bhj.v34i1.41902.

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Background: Limited contemporary data exist regarding the impact of SYNTAX score on procedural outcomes undergoing primary percutaneous coronary intervention(PCI) in acute STEMI patients. Objectives: To evaluate the significance of the SYNTAX score for predicting procedural outcome after primary PCI in patient with acute STEMI. Methods: This perspective observational study was conducted in the department of cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh from September, 2015 to September, 2016. 42 patients with acute STEMI who underwent primary PCI were considered for the study. But 2 patients were excluded from the study due to failure of primary PCI. The patients were divided into two groups: Group I (low Syntax score d”22) and Group II (high Syntax score > 22). The Syntax score of all patients were calculated from an initial coronary angiogram before primary PCI. Procedural outcome was observed in between two groups. Results: Among study patients 57.5% were in SYNTAX score d”22 (Group I) and 42.5% were in SYNTAX score >22 (Group II). Among traditional cardiovascular risk factors diabetes was significantly more prevalent in the Group II than Group I ( 82.4% vs 34.8%, p Â 0.003). Angiographic profile revealed maximum (69.6% vs 17.6%) culprit lesion in LAD artery in Group I and maximum culprit lesion (64.7% vs 21.7%) in RCA in Group II, these were the statistically significant between Group I and Group II (P<0.05). The high SYNTAX score group had lower ejection fraction (47.8±5.1 vs. 54.4±4.3, p= 0.04), lower TIMI flow 3 rate (76.47% vs 91.3%, p= 0.03 ) greater rate of MACE (29.4% vs. 4.3%, p=0.041), lower procedural success rate ( 76.47 vs. 91.3%, p= 0.046) compared to the low SYNTAX score group. ROC curve showed 77% sensitivity and 32% specificity for SYNTAX score when cut off value was 22 Performance test of SYNTEX score in the setting of Primary PCI outcome showed positive predictive value 83%. Conclusions: SYNTAX score was an independent variable that can predict procedural outcomes Bangladesh Heart Journal 2019; 34(1) : 5-10

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Squiers, John J., and J. Michael DiMaio. "SYNTAX Score II 2020." Journal of the American College of Cardiology 78, no. 12 (2021): 1239–41. http://dx.doi.org/10.1016/j.jacc.2021.07.028.

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Capodanno, Davide. "Beyond the SYNTAX Score." Circulation Journal 77, no. 5 (2013): 1131–38. http://dx.doi.org/10.1253/circj.cj-12-1613.

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Lim, Gregory B. "Logistic Clinical SYNTAX score." Nature Reviews Cardiology 9, no. 12 (2012): 673. http://dx.doi.org/10.1038/nrcardio.2012.150.

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Brugaletta, Salvatore, Michael Magro, Cihan Simsek, et al. "Plaque Compositional Syntax Score." JACC: Cardiovascular Imaging 5, no. 3 (2012): S119—S121. http://dx.doi.org/10.1016/j.jcmg.2011.12.009.

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Kundi, H. "Syntax score and inflammation." Herz 41, no. 6 (2016): 535–36. http://dx.doi.org/10.1007/s00059-016-4454-0.

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Islam, Md Shariful, Md Afzalur Rahman, Abdul Wadud Chowdhury, et al. "Impact of SYNTAX Score on In-hospital Outcome after Primary Percutaneous Coronary Intervention." Bangladesh Heart Journal 33, no. 2 (2018): 121–25. http://dx.doi.org/10.3329/bhj.v33i2.39308.

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Background: Limited contemporary data exist regarding the impact of SYNTAX score on in-hospital outcomes undergoing primary percutaneous coronary intervention(PCI) in acute STEMI patients. Objectives: To evaluate the significance of the SYNTAX score for predicting in- hospital outcome after primary PCI in patient with acute STEMI. Methods: This cohort study was conducted in the department of cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh from September, 2015 to September, 2016. 42 patients with acute STEMI who underwent primary PCI were considered for the study. But 2 patients were excluded from the study due to failure of primary PCI. The patients were divided into two groups: Group I (low SYNTAX score d”22) and Group II (high Syntax score > 22). The Syntax score of all patients were calculated from an initial coronary angiogram before primary PCI. In-hospital outcome was observed in between two groups. Results: Among traditional cardiovascular risk factors diabetes was significantly more prevalent in the Group II than Group I ( 82.4% vs 34.8%, p Â 0.003). Angiographic profile revealed maximum (69.6% vs 17.6%) culprit lesion in LAD artery in Group I and maximum culprit lesion (64.7% vs 21.7%) in RCA in Group II, these were the statistically significant between Group I and Group II (P<0.05). The high SYNTAX score group had lower TIMI 3 (76.47% vs 91.3%, p Â 0.03) compared to the low SYNTAX score group. But there were no significant difference in complications as arrhythmia (2.5% vs 0%), cardiogenic shock (2.5% vs 0%), heart failure (5% vs 2.5%) and mortality (5%vs 0%) between high and low SYNTAX score. Multivariate logistic regression analysis revealed SYNTAX score (OR = 5.95, p Â 0.001) was an independent predictor of in-hospital outcome in patients under going primary PCI. Performance test of SYNTEX score in the setting of Primary PCI outcome showed positive predictive value 83%. Conclusions: SYNTAX score was an independent variable that can predict in-hospital outcomes of patients with acute STEMI undergoing primary PCI. Bangladesh Heart Journal 2018; 33(2) : 121-125

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Serruys, Patrick, Yoshinobu Onuma, Scot Garg, et al. "Assessment of the SYNTAX score in the Syntax study." EuroIntervention 5, no. 1 (2009): 50–56. http://dx.doi.org/10.4244/eijv5i1a9.

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Farooq, Vasim, David van Klaveren, Ewout W. Steyerberg, and Patrick W. Serruys. "SYNTAX score II – Authors' reply." Lancet 381, no. 9881 (2013): 1899–900. http://dx.doi.org/10.1016/s0140-6736(13)61152-6.

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Soylemez, Selami. "Oxidative stress and Syntax score." Herz 42, no. 8 (2016): 793. http://dx.doi.org/10.1007/s00059-016-4516-3.

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Généreux, Philippe, Tullio Palmerini, Adriano Caixeta, and Gregg W. Stone. "A Guide to Calculating SYNTAX Score." Interventional Cardiology Review 7, no. 1 (2012): 21. http://dx.doi.org/10.15420/icr.2012.7.1.21.

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Since its first publication, the SYNTAX score has been used and validated in several subsets of lesions and populations. Despite some concerns about its reproducibility between cardiologists and its power of discrimination, the SYNTAX score remains the most powerful angiographic tool to predict events after percutaneous coronary intervention. Knowledge and mastering of the SYNTAX score definitions is of paramount importance and is the first step to an adequate stratification. This short article presents the different steps of the scoring system of SYNTAX score and focuses on the variables with the highest interobserver variability.

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Kang, Jeehoon, Kyung Woo Park, Jung-Kyu Han, et al. "THE CLINICAL SYNTAX SCORE IS SUPERIOR TO THE SYNTAX SCORE IN HIGH-RISK PATIENTS." Journal of the American College of Cardiology 67, no. 13 (2016): 171. http://dx.doi.org/10.1016/s0735-1097(16)30172-3.

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Kozieł-Siołkowska, Monika, Katarzyna Mitręga, Tomasz Podolecki, Anna Olma, Zbigniew Kalarus, and Witold Streb. "Lipoprotein(a) as an Independent Predictor of Elevated SYNTAX Score." Journal of Clinical Medicine 13, no. 23 (2024): 7109. http://dx.doi.org/10.3390/jcm13237109.

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Background/Objectives: Increased lipoprotein(a) [Lp(a)] level is associated with elevated possibility of atherosclerosis progression. SYNTAX score enables to grade the anatomy of coronary arteries. To identify the impact of increased Lp(a) level on SYNTAX score in individuals with acute myocardial infarction (AMI). Methods: In our analysis, we enrolled 173 consecutive adult patients hospitalized for AMI in a tertiary cardiology center from December 2022 to August 2023. Patient characteristics were compared for patients with SYNTAX score ≥ 23 (64 patients) and SYNTAX score < 23 (109 patients). The SYNTAX score was estimated based on the results of coronary angiography. Logistic regression analyses were performed to evaluate the factors associated with SYNTAX score. Results: Individuals with the SYNTAX score ≥ 23 were more likely to have arterial hypertension, diabetes mellitus, significant stenosis in the left main coronary artery, and higher Lp(a) levels than those with SYNTAX < 23 (all p < 0.05). On univariate analysis, age (OR 1.05, 95% CI 1.02–1.08, p = 0.001), Lp(a) levels (OR 1.04, 95% CI 1.01–1.06, p = 0.001), and arterial hypertension (OR 2.69, 95% CI 1.26–5.74, p = 0.011) were associated with SYNTAX score ≥ 23. Multivariable determinants of SYNTAX score ≥ 23 were as follows: Lp(a) levels (OR 1.03, 95% CI 1.01–1.08, p = 0.029), and age (OR 1.04, 95% CI 1.01–1.07, p = 0.005). The cut-off value for Lp(a) 166.16 nmol/L identifies patients with SYNTAX score ≥ 23 with 97% sensitivity and 44% specificity (area under curve 0.78, p < 0.001). Conclusions: Elevated Lp(a) concentration is associated with a higher SYNTAX score. A cut-off value of Lp(a) above 166.16 nmol/L allows us to identify subjects with SYNTAX score ≥ 23 with good specificity and sensitivity.

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Ranjan, Redoy, and Asit Baran Adhikary. "SYNTAX score and coronary artery bypass graft surgery in Bangladesh." Asian Cardiovascular and Thoracic Annals 27, no. 7 (2019): 542–47. http://dx.doi.org/10.1177/0218492319869787.

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Background The SYNTAX score is a helpful tool for determining the optimal myocardial revascularization strategy in complex coronary artery disease. The aim of this study was to assess whether the SYNTAX score predicts postoperative mortality in patients undergoing coronary artery bypass grafting. Methods The study included 1100 consecutive patients referred for coronary artery bypass graft surgery over a 4-year period. Angiographic data were interpreted by both experienced intervention cardiologists and cardiac surgeons. The patients were divided into three groups based on SYNTAX score tertiles: low ≤22 ( n = 560), intermediate 23–32 ( n = 360), and high ≥33 ( n = 180). Results Compared to patients with a low SYNTAX score, those with intermediate and high scores were significantly older ( p < 0.001), had a lower left ventricular ejection fraction ( p < 0.001), higher pulmonary artery pressure ( p < 0.001), and higher incidences of acute coronary syndrome and left main coronary artery disease. A significantly higher EuroSCORE ( p = 0.003) was also observed in patients with a higher SYNTAX score. Patients with intermediate and high SYNTAX scores had higher 5-year mortality rates (18.6% and 19.5%, respectively) than patients with low SYNTAX scores (9.5%, p < 0.05). In multivariate analysis, SYNTAX score was not an independent predictor of late mortality. Conclusion Although SYNTAX score is not independently predictive of late mortality in patients with complex coronary artery disease undergoing myocardial revascularization surgery, patients with lower SYNTAX scores had a lower mortality rate after coronary artery bypass graft surgery.

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Huda, S. M. Nurul, Mohammad Faisal Ibn Kabir, Mostashirul Haque, et al. "Correlation between the GRACE Risk Score and the SYNTAX Score in Patients with Non-ST-Segment Elevation Myocardial Infarction." University Heart Journal 19, no. 2 (2024): 49–54. http://dx.doi.org/10.3329/uhj.v3i1.73749.

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Background: The GRACE risk score is a valid clinical tool to risk stratify patients with non-ST-segment elevation myocardial infarction (NSTEMI). The SYNTAX score is a comprehensive angiographic grading tool to determine the anatomic complexity of coronary artery disease. Predicting the SYNTAX score before a coronary angiogram (CAG) can help with patient counseling, optimization of planning, and preparation for possible complex percutaneous procedures or CABG in patients with NSTEMI. Objective: The objective of this study is to determine the correlation between the GRACE risk score and the SYNTAX score in patients with NSTEMI. Materials and Methods: A total of 52 patients with NSTEMI undergoing coronary angiography were enrolled in this study. According to the calculated GRACE score on admission, patients were divided into a low-risk group (GRACE score ≤108), an intermediate-risk group (GRACE score = 109–140), and a high-risk group (GRACE score > 140). After coronary angiography, the SYNTAX score was calculated. The correlation between the scores was determined by Pearson’s correlation test. Results: The mean SYNTAX score in the low GRACE risk group was 9.5 ± 5.1, in the intermediate GRACE risk group it was 12.5 ± 7.6, and in the high GRACE risk group it was 18.5 ± 8.9, and the differences were significant (P value = 0.005). There was a significant positive correlation (r = 0.515, p = <0.001) between the GRACE risk score and the SYNTAX score in patients with NSTEMI. Conclusion: Our study demonstrates that in NSTEMI patients, the GRACE risk score has a significant positive correlation with the SYNTAX score. University Heart Journal 2023; 19(2): 49-54

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Sunardi, Andrew Eka Pramudita, Dewi Utari Djafar, Edmond Leonard Jim, and Fima Lanra Fredrik Gerald Langi. "THE USE OF BASEL SCORE IN EARLY DETECTION OF CORONARY LESION SEVERITY IN NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND UNSTABLE ANGINA PECTORIS." Jurnal Widya Medika 9, no. 2 (2023): 79–90. http://dx.doi.org/10.33508/jwm.v9i2.5060.

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Early diagnosis of cardiac ischemia is crucial for effective management of acute myocardial infarction. The BASEL (Better Analysis of ST-segment Elevations and Depressions in a 12-leads-ECG) score has been shown to provide additional diagnostic value to the established electrocardiographic (ECG) criteria. This study aimed to evaluate the use of BASEL score to determine the severity of coronary lesions in patients with non-ST segment elevation acute coronary syndrome. This study used a cross-sectional approach and was conducted from January 2021 to January 2022. From a total of 90 subjects, more than three-quarters were male, while the mean age was 60.3 years. The median BASEL score was 2.3 (1–4.2). GRACE 2.0 score had a mean of 97.3±26. The SYNTAX I score had a mean of 25±15.6, the SYNTAX II – PCI median score was 34.5 (25.9-42.4), and the SYNTAX II-CABG mean score was 23.4±11.9. The BASEL score showed a significant association with the SYNTAX I score both in univariate 2.60 (2.60-3.59), p<0.001, and in multivariate model 2.16 (0.99-3.34), p=0.001. The BASEL score appeared superior to the GRACE 2.0 score for lesion classification prediction according to the SYNTAX I AUC Z=3.29; p<0.001 for SYNTAX score of ≥33 and AUC Z=3.72, p<0.001 for SYNTAX score of >22. However, the SYNTAX II-PCI score, the classification ability of BASEL and GRACE scores did not differ AUC Z=1.02, p=0.306 for SYNTAX scores ≥33, and AUC Z=0.85, p=0.393 for SYNTAX score of >22. The BASEL score is significantly associated with the SYNTAX I score and provide better discrimination than the GRACE 2.0 score in determining the severity of coronary lesion.

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Maleki, Mehdi, Arezou Tajlil, Ahmad Separham, et al. "Association of neutrophil to lymphocyte ratio (NLR) with angiographic SYNTAX score in patients with non-ST-Segment elevation acute coronary syndrome (NSTE-ACS)." Journal of Cardiovascular and Thoracic Research 13, no. 3 (2021): 216–21. http://dx.doi.org/10.34172/jcvtr.2021.40.

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Introduction: Considering the role of inflammation in pathogenesis of atherosclerosis, we aimed to investigate the association of presentation neutrophil to lymphocyte ratio (NLR) with complexity of coronary artery lesions determined by SYNTAX score in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: From March 2018 to March 2019, we recruited 202 consecutive patients, who were hospitalized for NSTE-ACS and had undergone percutaneous coronary intervention in our hospital. The association of presentation NLR with SYNTAX score was determined in univariate and multivariate linear regression analysis. Results: Higher NLR was significantly associated with higher SYNTAX score (beta= 0.162, P=0.021). In addition, older age, having hypertension, higher TIMI score, and lower ejection fraction on echocardiographic examination were significantly associated with higher SYNTAX score. TIMI score had the largest beta coefficient among the studied variables (TIMI score beta=0.302, P<0.001). In two separate multivariate linear regression models, we assessed the unique contribution of NLR in predicting SYNTAX score in patients with NSTE-ACS. In the first model, NLR was significantly contributed to predicting SYNTAX score after adjustment for age, sex, and hypertension as covariates available on patient presentation (beta=0.142, P=0.040). In the second model, NLR was not an independent predictor of SYNTAX score after adjustment for TIMI score (beta=0.121, P=0.076). Conclusion: In NSTE-ACS, presentation NLR is associated with SYNTAX score. However, NLR does not contribute significantly to the prediction of SYNTAX score after adjustment for TIMI score. TIMI risk score might be a better predictor of the SYNTAX score in comparison to NLR.

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He, Yong-Ming, Li Shen, and Jun-Bo Ge. "Fallacies and Possible Remedies of the SYNTAX Score." Journal of Interventional Cardiology 2020 (December 15, 2020): 1–7. http://dx.doi.org/10.1155/2020/8822308.

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Quite a few studies have revealed the clinical values regarding the outcome predictions in the cohort of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial and decision-making with the SYNTAX score. The Evaluation of Xience Everolimus-Eluting Stent Versus Coronary Artery Bypass Surgery for Effectiveness of Left-Main Revascularization (EXCEL) and Nordic-Baltic-British left main revascularization (NOBLE) studies are the largest international randomized studies so far, comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) in the treatment of left main coronary artery disease. Unfortunately, both studies failed to validate the value of the SYNTAX score in the selection of revascularization strategies for patients with coronary artery diseases (CAD).. This scenario prompted us to reconsider the inherent fallacies of the SYNTAX score in its derivation. We pointed out eight fallacies for the SYNTAX score in this paper. A recently developed Coronary Artery Tree description and Lesion EvaluaTion (CatLet) score, available at http://www.catletscore.com, a novel angiographic scoring system, could be the remedies for the SYNTAX score.

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Dawkins, Keith, Marie-Angèle Morel, and Patrick Serruys. "Counting the score: the SYNTAX Score and coronary risk." EuroIntervention 5, no. 1 (2009): 33–35. http://dx.doi.org/10.4244/eijv5i1a6.

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Hassan, Maroof, Ghulam Kubra, Mehwish Sabeen, Deebaj Nadeem, Asma Murtaza, and Faiza Sikandari. "Correlation of TIMI Risk Score and GRACE Risk Score with Lesion of Coronary Artery Disease in Patients with Non-ST Segment Elevation Acute Coronary Syndrome." Pakistan Journal of Medical and Health Sciences 17, no. 6 (2023): 205–7. http://dx.doi.org/10.53350/pjmhs2023176205.

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Objective: To compare the correlation of “thrombolysis in myocardial infarction (TIMI)” and “Global Registry of Acute Coronary Events (GRACE)” risk score with lesion of coronary artery disease in patients with non-ST segment elevation acute coronary syndrome. Study Design: Cross-sectional study. Place and Duration: The Department of adult cardiology, “National Institute of Cardiovascular Diseases (NICVD)”, Karachi, Pakistan, from January 2021 to July 2021. Methodology: Demographics, weight, height, risk factors along with the required information needed for TIMI and GRACE score were obtained at the time of presentation in emergency department as per the scoring criteria. SYNTAX score was calculated after performing conventional angiography of the patients, using SYNTAX.com calculator. Results: In a total of 104 patients, the mean age was 57.21±12.22 years while 56 (53.8%) patients were male. Hypercholesterolemia was found in 33 (31.7%) patients. Mean score of TIMI was calculated as 4.680±2.064 while SYNTAX score was calculated as 26.45±12.94 and the correlation between TIMI risk score and SYNTAX score was noted as (r=0.109) and P value was found to be non-significant i.e. (P=0.270). Mean score of GRACE was noted as 135.38±90.88 while SYNTAX score was noted as 26.45±12.94 and the correlation between GRACE risk score and SYNTAX score was documented as (r=0.179) and P value was found to be non-significant i.e. (P=0.068). Practical Implications: Both TIMI and GRACE risk scoring systems showed weak correlations with SYNTAX scores. Conclusion: There is a weak correlation between TIMI risk score and SYNTAX score as well as GRACE risk score and SYNTAX score. Keywords: Acute coronary syndrome, coronary artery disease, GRACE score, myocardial infarction, thrombolysis.

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Freemantle, Nick, and Domenico Pagano. "Concerns with the new SYNTAX score." Lancet 397, no. 10276 (2021): 795. http://dx.doi.org/10.1016/s0140-6736(21)00223-3.

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Yayla, Çağri, Kadriye Gayretli Yayla, Ahmet Goktug Ertem, Sefa Unal, Mustafa Karanfil, and Koray Demirtas. "SYNTAX Score and Severity of Atherosclerosis." Angiology 70, no. 6 (2018): 567. http://dx.doi.org/10.1177/0003319718802051.

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Xie, Haotai. "Rethinking the Functional SYNTAX Score Threshold." JACC: Cardiovascular Interventions 17, no. 22 (2024): 2707. http://dx.doi.org/10.1016/j.jcin.2024.10.001.

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Ikeno, Fumiaki, Maria Mori Brooks, Kaori Nakagawa, et al. "SYNTAX Score and Long-Term Outcomes." Journal of the American College of Cardiology 69, no. 4 (2017): 395–403. http://dx.doi.org/10.1016/j.jacc.2016.10.067.

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Morice, Marie-Claude. "Has the SYNTAX Score Become Obsolete?" Journal of the American College of Cardiology 72, no. 12 (2018): 1330–31. http://dx.doi.org/10.1016/j.jacc.2018.07.023.

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Cerit, Levent, Aziz Günsel, Zeynep Cerit, et al. "Mitral Annular Calcification and Syntax Score." American Journal of Cardiology 121, no. 8 (2018): e7-e8. http://dx.doi.org/10.1016/j.amjcard.2018.03.043.

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Cerit, Levent. "SYNTAX score and left ventricular remodelling." International Journal of Cardiology 223 (November 2016): 465. http://dx.doi.org/10.1016/j.ijcard.2016.08.180.

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Bach, Richard G. "SYNTAX score II predicted mortality after PCI or CABG in complex CAD better than SYNTAX score." Annals of Internal Medicine 159, no. 2 (2013): JC5. http://dx.doi.org/10.7326/0003-4819-159-2-201307160-02005.

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Sofidis, Georgios, Nikolaos Otountzidis, Nikolaos Stalikas, et al. "Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome." Journal of Clinical Medicine 10, no. 10 (2021): 2210. http://dx.doi.org/10.3390/jcm10102210.

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The GRACE score constitutes a useful tool for risk stratification in patients with acute coronary syndrome (ACS), while the SYNTAX score determines the complexity of coronary artery disease (CAD). This study sought to correlate these scores and assess the accuracy of the GRACE score in predicting the extent of CAD. A total of 539 patients with ACS undergoing coronary angiography were included in this analysis. The patients were classified into those with a SYNTAX score < 33 and a SYNTAX score ≥ 33. Spearman’s correlation and receiver operator characteristic analysis were conducted to investigate the role of the GRACE score as a predictor of the SYNTAX score. There was a significantly positive correlation between the SYNTAX and the GRACE scores (r = 0.32, p < 0.001). The GRACE score predicted severe CAD (SYNTAX ≥ 33) moderately well (the area under the curve was 0.595 (0.522–0.667)). A GRACE score of 126 was documented as the optimal cut-off for the prediction of a SYNTAX score ≥ 33 (sensitivity = 53.5% and specificity = 66%). Therefore, our study reports a significantly positive correlation between the GRACE and the SYNTAX score in patients with ACS. Notably, NSTEMI patients with a high-risk coronary anatomy have higher calculated GRACE scores. A multidisciplinary approach by a heart team could possibly alter the therapeutic approach and management in patients presenting with ACS and a high calculated GRACE score.

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Hatamnejad, Mohammad Reza, Amir Arsalan Heydari, Maryam Salimi, Soodeh Jahangiri, Mehdi Bazrafshan, and Hamed Bazrafshan. "The utility of SYNTAX score predictability by electrocardiogram parameters in patients with unstable angina." BMC Cardiovascular Disorders 22, no. 1 (2022): 1–11. https://doi.org/10.5281/zenodo.6055590.

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SYNTAX score is one of the risk assessment systems to predict cardiac events in acute coronary syndrome patients. Despite the large number of SYNTAX score benefits, invasive methods such as coronary angiography are necessary to perform the scoring. We hypothesized that ECG parameters could predict the SYNTAX score in unstable angina patients. During the retrospective cohort study, a total number of 876 patients were diagnosed with unstable angina. After applying the exclusion criteria, 600 patients were divided into tertiles based on the SYNTAX scores as low (0–22), intermediate (23–32), and high (≥ 33). The association between ECG parameters and SYNTAX score was investigated. The study included 65% men and 35% women with a mean age of 62.4 ± 9.97 years. The delayed transition zone of QRS complex, ST-depression in inferior-lateral territories or/and in all three territories, and T-wave …

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Lison, Linda, Irawan Yusuf, Bambang Sutrisna, Peter Kabo, Teguh Santoso, and Ferry Sandra. "Which Biology Marker Can be a Predictor for Higher Syntax Score?" Indonesian Biomedical Journal 6, no. 2 (2014): 107. http://dx.doi.org/10.18585/inabj.v6i2.37.

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BACKGROUND: Syntax score is a lesion-based angiographic scoring system, originally devised to grade the anatomic complexity of coronary artery disease (CAD) and thereby facilitate consensus in the study of a diagnostic angiogram between surgeons and interventional cardiologists. Suitable biology marker to predict the severity of CAD and to have a treatment decision for revascularization by percutaneous coronary intervention (PCI) or bypass surgery, is still unknown. Which biology marker can be a predictor for higher Syntax score remains unknown as well.METHODS: Severity of 105 patients who underwent coronary angiography, were evaluated with Syntax score. Laboratory tests were conducted for routine blood test, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), high-sensitivity C-reactive protein (hs-CRP), total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, kidney function, creatinine and hemoglobin A1c (HbA1c).RESULTS: Ureum had significant correlation with Syntax score, p=0.016 and 95% confidence interval (CI)=0.05-0.55. Result of logistic regression analysis showed that HDL and haematocrit had significant correlation with Syntax score, with cut off point 34 (p=0.02, p=0.0033, respectively). Based on multi-variate analysis, Syntax score 34 = 16 (HDL ≤40 + Ureum ≥23) + 10 (Neutrophil/Lymphocyte ≥3.789) +10 (HbA1c ≥7 ) + 13 ( monocyte ≥9%).CONCLUSION: HDL cholesterol, ureum, neutrophil-lymphocyte ratio, HbA1c and monocyte altogether can predict the higher Syntax score.KEYWORDS: syntax, neutrophil, lymphocyte, HDL, cholesterol, ureum, HbA1c, monocyte

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Čumić, Jelena, Radmila Karan, Ana Cvijić, Dušan Andrić, Jovan Petrović, and Predrag Stevanović. "Significance of serum uric acid level and syntax score in long-term survival of cardiac surgery patients: Uric acid in cardiac surgery patients." Serbian Journal of Anesthesia and Intensive Therapy 45, no. 7-8 (2023): 137–46. http://dx.doi.org/10.5937/sjait2308137c.

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Introduction: The connection between serum uric acid (SUA) and the occurrence of cardiovascular diseases has long been known. Despite the SYNTAX score emerging as useful for risk identification and stratification in the clinical practice of interventional cardiology, it has not been proven useful in cardiac surgical clinical practice. The aim of the paper is to examine the significance of SUA levels, the significance of the SYNTAX score and the Clinical SYNTAX score in predicting the long-term survival of cardiac surgery patients. Methods: A retrospective analysis of 160 cardiac surgery patients operated on between 2013 and 2014 was conducted. SUA, SYNTAX and clinical SYNTAX score was measured. In the follow-up period of 3 years, clinical outcomes of patients were tracked. Results: The average SYNTAX score was 25.2 ± 11.4, the average Clinical SYNTAX score was 26.9 ± 8.3. The average preoperative SUA level was 361 ± 94.1 mg/ dL. No statistically significant difference was found in the values of the ejection fraction, end-diastolic and end-systolic dimensions of the left ventricle in relation to the treatment outcome in the long-term follow-up (p > 0.05). Preoperative left atrial diameter was significantly higher in deceased patients (p = 0.013). No statistically significant difference was found in the average values of the syntax score in relation to the treatment outcome in the long-term follow-up (p = 0.388), while a statistically significant difference was found in the values of the clinical SYNTAX score (p = 0.029). A statistically significant difference was found in the preoperative values of SUA in relation to the postoperative occurrence of adverse cardiovascular events (p = 0.035). Conclusion: Significant predictors of mortality in the long-term follow-up of cardiac surgery patients were left atrial diameter and clinical SYNTAX score. Predictors of adverse cardiovascular outcomes were left atrial diameter, clinical SYNTAX score and preoperative serum uric acid level.

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Volkan Emren, Sadık, Rahman Bilal Gediz, Oktay Şenöz, et al. "Decreased heart rate recovery may predict a high SYNTAX score in patients with stable coronary artery disease." Bosnian Journal of Basic Medical Sciences 19, no. 1 (2019): 109–15. http://dx.doi.org/10.17305/bjbms.2019.3725.

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An impaired heart rate recovery (HRR) has been associated with increased risk of cardiovascular events, cardiovascular, and all‐cause mortality. However, the diagnostic ability of HRR for the presence and severity of coronary artery disease (CAD) has not been clearly elucidated. Our aim was to investigate the relationship between HRR and the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score in patients with stable CAD (SCAD). A total of 406 patients with an abnormal treadmill exercise test and ≥50% coronary stenosis on coronary angiography were included. The HRR was calculated by subtracting the HR in the first minute of the recovery period from the maximum HR during exercise. The SYNTAX score ≥23 was accepted as high. Correlation of HRR with SYNTAX score and independent predictors of high SYNTAX score were determined. A high SYNTAX score was present in 172 (42%) patients. Mean HRR was lower in patients with a high SYNTAX score (9.8 ± 4.5 vs. 21.3 ± 9, p < 0.001). The SYNTAX score was negatively correlated with HRR (r: -0.580, p < 0.001). In multivariate logistic regression analysis, peripheral arterial disease (OR: 13.3; 95% CI: 3.120–34.520; p < 0.001), decreased HRR (OR: 0.780; 95% CI: 0.674–0.902; p = 0.001), peak systolic blood pressure (OR: 1.054; 95% CI: 1.023–1.087; p = 0.001), and peak HR (OR: 0.950; 95% CI: 0.923–0.977; p < 0.001) were found to be independent predictors of a high SYNTAX score. Our results showed that HRR is significantly correlated with the SYNTAX score, and a decreased HRR is an independent predictor of a high SYNTAX score in patients with SCAD.

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Durmuş, Gündüz, Erdal Belen, Akif Bayyigit, Muhsin Kalyoncuoğlu, and Mehmet Mustafa Can. "The Relationship between Inter-Arm Blood Pressure Difference and Coronary Artery Disease Severity Calculated by the SYNTAX Score." International Journal of Hypertension 2018 (September 13, 2018): 1–5. http://dx.doi.org/10.1155/2018/9370417.

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Objectives. The inter-arm systolic blood pressure difference (IASBPD) is closely related to cardiovascular mortality and morbidity. The SYNTAX score indicates the extent and complexity of coronary artery disease, which are determined by coronary angiography. The aim of our study is to examine the relationship between the IASBPD (which is easily calculated in routine practice) and the SYNTAX score. Methods. 104 patients were included in this cross-sectional study. The IASBPD was calculated by blood pressure measurements obtained simultaneously from both arms. The SYNTAX score was calculated by coronary angiography. Results. Patients were divided into two groups: those with a high SYNTAX score (≥20) and those with a low SYNTAX score (<20). The mean IASBPD values were significantly higher in the group with a high SYNTAX score (≥20) (p<0.001). The patients with IASBPD≥10 were more likely to have a high SYNTAX score compared to the patients with IASBPD<10 (p<0.001). Multiple logistic regression analysis revealed that only the IASBPD values were found to be independently associated with high SYNTAX score (OR: 1.717 (CI: 1.307-2.257), p<0.001). Conclusion. The IASBPD values obtained by only blood pressure measurements are closely related to the extent of coronary artery disease.

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Mathew, Cibu, Shilpa Kannamkumarath, Sajna Mathumkunnath Vijayan, and Karunadas Prabhakaran Chakkalakal. "Inter Arm Blood Pressure Difference in Patients Undergoing Coronary Angiography and Its Relationship to Coronary Artery Disease Complexity." Journal of Evidence Based Medicine and Healthcare 7, no. 49 (2020): 2968–73. http://dx.doi.org/10.18410/jebmh/2020/607.

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BACKGROUND Blood pressure (BP) in the right and left arms can be different. This inter arm difference (IAD) in BP can be systolic (IAD - SBP) and / or diastolic (IAD - DBP). IAD of ≥ 10 mm of Hg is considered significant. SYNTAX score is used to assess the complexity of coronary artery lesions. Prevalence of IAD in patients undergoing coronary angiography (CAG) and its relationship to complexity of coronary artery disease is unclear. METHODS In 100 patients taken up for CAG, BP was recorded in both the arms simultaneously with automated devices using oscillometric method. Significant IAD was defined as ≥ 10 mm of Hg. Using SYNTAX score, patients were divided into two groups; those with a lower score < 22 and those with a higher score ≥ 22. Data was analysed using SPSS version 16. Mean difference of the variables was analysed using Independent t test. Association of interarm BP difference and high SYNTAX score was analysed using Chi Square test. RESULTS Significant IAD of ≥ 10 mm of Hg was noted in 16 out of 100 patients. SYNTAX score of ≥ 22 was seen in 30 patients. IAD - SBP ≥ 10 was noted in 23.3 % in patients with higher SYNTAX score as against 2.9 % in those with lower score (p 0.001). IAD - DBP ≥ 10 was seen in 20 % of patients with higher SYNTAX score as against 1.4 % in those with lower SYNTAX score (p 0.001). CONCLUSIONS Interarm blood pressure difference of ≥ 10 mm of Hg is seen in 16 % of cases taken up for coronary angiogram. Patients with IAD ≥ 10 mm of Hg had higher SYNTAX score of ≥ 22 suggesting more complex coronary artery disease. KEYWORDS Interarm Blood Pressure Difference, SYNTAX Score

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Khawaja, Asma Zafar, Syed Khurram Shahzad, Muhammad Khalil, et al. "Comparison of GRACE Score and SYNTAX Score in Predicting Complexity of Coronary Artery Disease in Patients with NST-ACS." Pakistan Armed Forces Medical Journal 73, SUPPL-3 (2023): S463–468. http://dx.doi.org/10.51253/pafmj.v73isuppl-3.10664.

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Objective: To compare the GRACE score and SYNTAX score in predicting Coronary Artery Disease (CAD) severity and the variation of GRACE score with respect to SYNTAX score to assess severity of CAD. Study Design: Analytical, Cross-sectional study. Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi Pakistan, from Jan 2023 to Jun 2023. Methodology: Data was gathered from n=139 participants by using consecutive sampling technique on a data collection tool.Study variables such as demographics, comorbids, clinical characteristics and SYNTAX and GRACE score were noted to asses their role in determining CAD severity. An experienced cardiologist was assigned to analyze the coronary angiogram findings, performed by using conventional techniques through radial artery, ulnar or femoral artery access. SPSS version-24.00 was used for data management and analysis. Chi square test and Pearson correlation was applied to find the association and correlation respectively. Results: Mean age of study participants was 62.09±9.74 years and males were more in number 114(82.0%). Ninety three (66.9%) patients had NSTEMI. Gender (p=0.011,0.007), was significantly associated with SYNTAX score as well as GRACE score respectively and diabetic status (p=0.003) with GRACE score. There was a strong and positive correlation between GRACE score and SYNTAX score (r=0.64; p<0.001). Both scores showed significant association with CAD severity (p<0.05). Conclusion: There exists a statistically significant and positive correlation between GRACE score and SYNTAX score in non-ACS (NSTEMI and UA) patients who had confirmed diagnosis of CAD on coroangiogram. The greater the GRACE score, the greater was........

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Abdel-Galeel, Ahmed, Doaa Magdy, Hatem Abdel Rahman Helmy, Amr Ahmed Youssef, and Ayman Ibrahim. "Correlation between ankle–brachial index, wall motion score index, and SYNTAX score in acute coronary syndrome patients." Romanian Journal of Cardiology 32, no. 1 (2022): 14–21. http://dx.doi.org/10.2478/rjc-2022-0011.

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Abstract Background Ankle–brachial index (ABI) is a noninvasive and cheap measurement that is used to define peripheral arterial disease (PAD). It is used as a marker to predict coronary artery disease (CAD). The SYNTAX score was created to quantify the extent of CAD in patients with multivessel disease. Two-dimensional transthoracic echocardiography (TTE) is a useful method for evaluating left ventricular (LV) volumes and ejection fraction (EF) in CAD patients. The aim of the study is to find the relationship between ABI and wall motion score index (WMSI) in order to better predict the severity of CAD. Patients and Methods One hundred and twenty-five CAD patients were evaluated by echocardiography to calculate WMSI before they underwent coronary angiography to assess the SYNTAX score. ABI measurement was done. Results The study included 54.4% males with a mean age of 55.11 years. Nearly half of them had ST-segment elevation myocardial infarction (STEMI). There was a negative correlation between the SYNTAX score and AKI, a positive correlation between the SYNTAX score and WMSI, and a negative correlation between WMSI and ABI. Predictors of high SYNTAX were ABI <0.9, low left ventricular ejection fraction (LVEF), high WMSI, and multivessel coronary artery affection. Conclusion ABI is a noninvasive test that could predict the severity of CAD. WMSI is an echocardiographic parameter that could be used as an indicator of CAD severity. Combining both ABI and WMSI could help in predicting complex CAD better.

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Abimanyu, Roni, Andika Sitepu, and Ali Nafiah Nasution. "Comparison of Syntax II Score And Grace Score As Predictors of Major Cardiovascular Events 30 Days after Treatment in STEMI Undergoing PPCI." Journal of Society Medicine 3, no. 6 (2024): 171–77. https://doi.org/10.47353/jsocmed.v3i6.150.

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Introduction: IMA-EST is still the main cause of morbidity and mortality in Coronary Artery Disease (CAD) and PPCI is still the main treatment method for IMA-EST patients. Even though PPCI has been undergone, patients are reported to still experience mortality and morbidity both in hospital and after discharged. The SYNTAX II score uses clinical, laboratory and anatomical parameters that are believed to be better than the GRACE score to predict mortality and morbidity. Method: This study is an observational analytic with a retrospective cohort design in STEMI patients who underwent PPCI at HAM General Hospital from January 2023 to June 2023. Patients who were diagnosed with STEMI and underwent with PPCI had their GRACE score and SYNTAX II score calculated and followed for 30 days. SYNTAX-II Score’s cut-off point, sensitivity and specificity as well as predictive possibilities in predicting adverse outcomes were determined. Then bivariate analysis was carried out on each SYNTAX-II Score and GRACE score. Results: The study subjects totaled 73 people with an average age of 56.05 ± 10.07 years. The incidence of MACE 30 days after treatment in our sample was 23.3%. It was found that the SYNTAX II score could well predict occurrence of MACE 30 days after treatment (cut off 33,75, AUC 0.861; 0.773 – 0.949; sensitivity 94.1%; specificity 69.6%, PPV 94.1% and NPV 67.6). The result of the bivariate analysis of the SYNTAX-II Score were: P < 0,0001; OR: 18,353; 95%; CI: 2,566 – 131,241and the results of the GRACE Score were: P < 0,006; OR 5,854; 95%; CI: 1,442 – 23,764. Conclusion: The SYNTAX II score is better to predict occurrence of MACE 30 days after treatment in STEMI patients who undergoing PPCI compared to the GRACE score.

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Chiong, Terri, Esther S. H. Cheow, Chin C. Woo, et al. "Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery." Open Cardiovascular Medicine Journal 10, no. 1 (2016): 48–56. http://dx.doi.org/10.2174/1874192401610010048.

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Aims: The SYNTAX score correlate with major cardiovascular events post-revascularization, although the histopathological basis is unclear. We aim to evaluate the association between syntax score and extracellular matrix histological characteristics of aortic punch tissue obtained during coronary artery bypass surgery (CABG). This analysis compares coronary artery bypass surgery patients with High and Low syntax score which were followed up for one year period. Methods and Results: Patients with High (score ≥ 33, (n=77)) and Low Syntax Scores (score ≤ 22, (n=71)) undergoing elective CABG were recruited prospectively. Baseline clinical characteristics and surgical risks were well matched. At 1 year, EMACCE (Sum of cardiovascular death, stroke, congestive cardiac failure, and limb, gut and myocardial ischemia) was significantly elevated in the High syntax group (P=0.022). Mass spectrometry (MS)-based quantitative iTRAQ proteomic results validated on independent cohort by immunohistochemistry (IHC) revealed that the High syntax group had significantly upraised Collagen I (P<0.0001) and Elastin (P<0.0001) content in ascending aortic wall. Conclusion: This study shows that aortic extracellular matrix (ECM) differ between High and Low syntax groups with up-regulation of Collagen I and Elastin level in High Syntax Score group. This identifies aortic punches collected during CABG as another biomarker source related with atherosclerosis severity and possible clinical outcome.

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Takashima, Hiroaki, Yasushi Kuhara, Kenji Asai, et al. "The Association of Coronary Artery Calcium Score and SYNTAX Score." American Journal of Cardiology 111, no. 7 (2013): 86B. http://dx.doi.org/10.1016/j.amjcard.2013.01.216.

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Mohammed, Tariq E., Mohamed Mahmoud, and Ahmed El-Tayeb. "The relationship between blood pressure measurement in both arms and the severity of coronary artery disease by SYNTAX score." Al-Azhar Assiut Medical Journal 22, no. 3 (2024): 158–65. https://doi.org/10.4103/azmj.azmj_211_20.

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Background and aim This study aims to evaluate the relationship between inter-arm blood pressure difference and the severity of coronary artery disease assessed by SYNTAX score in patients undergoing coronary angiography (CA). Patients and methods A total of 100 patients undergoing CA were enrolled in the study, with calculation of inter-arm blood pressure difference by BP measurements 1 day before CA, and mean BP was calculated for both arms using all measurements to be compared with SYNTAX score. Results In our study, there was a highly significant relationship between mean inter-arm blood systolic pressure difference (IASBPD) and incidence of SYNTAX score more than or equal to 20 (P<0.001). Moreover, there was a significant relationship between the incidence of SYNTAX score more than or equal to 20 and the incidence of diabetes mellitus, dyslipidemia, high total cholesterol level, high low-density lipoprotein level (P=0.022, 0.035, 0.016, and 0.021, respectively). The mean IASBPD was highly significantly higher and also exaggerated IASBPD was significantly higher in patients with high SYNTAX score compared with patients with low SYNTAX score (P<0.001 and P=0.001, respectively). Conclusion There was a highly significant positive linear correlation between SYNTAX score and mean IASBPD.

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Nemik, D. B., G. V. Matyushin, and S. A. Ustyugov. "ROLE OF SYNTAX SCORE SCALE IN THE STRATIFICATION OF THE NOSOCOMIAL RISK OF CARDIOVASCULAR COMPLICATIONS AND LETHALITY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION." Rational Pharmacotherapy in Cardiology 14, no. 3 (2018): 324–29. http://dx.doi.org/10.20996/1819-6446-2018-14-3-324-329.

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The lethality of patients with acute myocardial infarction with ST-segment elevation (STEMI) depends on many factors. In conditions of timely transportation of the patient to the center of percutaneous coronary intervention one of these factors is the severity of the coronary bed lesion. In clinical practice, the most common method of assessing such lesions is the SYNTAX Score scale.Aim. To study the impact of the assessment by angiographic SYNTAX Score scale on in-hospital complications and lethality in patients with STEMI.Material and methods. The single-center observational retrospective study was performed. The medical data of 816 cases of treatment of patients with STEMI in the first 6 hours from the onset of symptoms were analyzed. All patients underwent reperfusion therapy (primary percutaneous coronary intervention or pharmacoinvasive strategy (FIS)) with assessment of the SYNTAX Score index prior to intervention. The main group (SYNTAX Score ≤22 points) and the comparison group (SYNTAX Score index >22 points) were comparable in terms of clinical characteristics and time delays.Results. An increase in the SYNTAX Score more than 22 points was an independent predictor of hospital complications and lethality (4.9% for SYNTAX Score ≤22 points and 21.9% – for >22 points). The group with a high SYNTAX index was older, had a higher proportion of smokers (46.8% vs 36.1%, p=0.015) and patients with myocardial infarction history (38.5% vs 20.6%, p<0.001), fewer patients to whom the FIS was applied (33.3% vs 45.7%; p=0.017). Nevertheless, in multivariate analysis, the initial clinical data of patients influenced the hospital prognosis, first of all in patients with SYNTAX Score ≤22 points. The group with a more severe lesion of the coronary bed was represented by patients with frequent development of pulmonary edema, cardiogenic shock and ventricular fibrillation. Cardiac complications in this group of patients were less dependent on the initial characteristics. Strong SYNTAX Score correlations were found with left ventricular ejection fraction (r=-0.156, p<0.001), the number of implanted stents (r=0.226, p<0.001), and with complications and lethality. The frequency of hemorrhagic complications did not depend on the severity of the coronary bed lesion.Conclusion. The use of the SYNTAX Score scale in clinical practice is scientifically grounded and advisable. Stratification of high-risk patients with STEMI during primary angiography based on the SYNTAX Score scale has a high prognostic value.

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Sinaga, Akbar, Refli Hasan, Abdul Halim Raynaldo, Harris Hasan, Nizam Zikri Akbar, and Cut Aryfa Andra. "Association of Triglyceride/High Density Lipoprotein Cholesterol Ratio and Coronary Lesion Severity in Acute Myocardial Infarction Patients at Adam Malik Hospital, Medan." Journal of Society Medicine 2, no. 3 (2023): 34–41. http://dx.doi.org/10.47353/jsocmed.v2i3.30.

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Introduction: Coronary heart disease is the leading cause of worldwide death. A number of markers have been identified in terms of the atherogenic potential of the lipid profile.The TG/HDL-C ratio is an easy and economical non-invasive examination method as a predictor of coronary heart disease severity. The aim of this study is to assess the relationship of the TG/HDL ratio with the severity of coronary lesions. Method: This cross-sectional study included 53 acute myocardial infarction patients undergoing coronary angiography. Exclusion criteria include (1)AMI patients receiving fibrinolytic therapy, (2) Patients who have routinely consumed lipid lowering drug for 6 weeks,(3) Incomplete coronary angiography and medical records. The TG/HDL ratio is the result of dividing the triglyceride value by HDL. The TG/HDL ratio was divided into 2 groups, namely the TG/HDL ratio <4 group and the TG/HDL ratio >4 group. The severity of coronary lesions was described by the SYNTAX score, which was divided into two: the low SYNTAX score group (≤22) and patients with a low SYNTAX score (≤22) and medium-high SYNTAX score (≥23). Bivariate analysis was performed to find the relationship between the TG/HDL ratio and the SYNTAX score. The value of p<0.05 was considered statistically significant. Results: From 53 patients, 26 patients (49.1%) had a SYNTAX score ≥ 23 and 27 patients (50.9%) had a SYNTAX score < 23. Patients with NSTEMI, DM risk factors, and obesity were higher in the SYNTAX score group ≥23. From the results of statistical analysis, there was a significant relationship between the TG/HDL ratio with coronary lesion severity (p = 0,004). Conclusion: Enhancement of TG/HDL ratio is correlated with coronary lesion severity in acute myocardial infarction patients using the SYNTAX score.

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Rossi Ferreira, Raphael, Tania Falcão, and Fernando Atik. "Prognostic value of residual SYNTAX score on in-hospital and follow-up clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing pharmacoinvasive strategy." Journal of Transcatheter Interventions 31 (February 19, 2024): 1–7. http://dx.doi.org/10.31160/jotci202331a20230017.

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Background Multivessel coronary artery disease is a challenge in clinical practice. An individualized approach should consider not only the patient characteristics, but also a multidisciplinary approach, together with the Heart Team. Multiple angiographic scores have been proposed with the aim of quantifying the risk associated with multivessel coronary artery disease. Residual SYNTAX score has been proposed as a method to systematically characterize and quantify residual coronary disease after percutaneous coronary intervention. There are few data in the literature correlating the residual SYNTAX score in patients with ST-segment elevation myocardial infarction undergoing pharmacoinvasive strategy. The objective of this study was to evaluate the SYNTAX score and residual SYNTAX score as predictors of in-hospital and medium-term outcomes (180 to 380 days) in patients with multivessel coronary artery disease in the setting of ST-segment elevation myocardial infarction, after successful fibrinolytic therapy. Methods In a cross-sectional, analytical, and prospective study, we evaluated residual SYNTAX score as predictor of in-hospital and medium-term outcomes (6 months to 1 year), in patients with multivessel coronary artery disease, in the setting of ST-segment elevation myocardial infarction after pharmacoinvasive strategy. Results Between August 2019 and December 2020, 108 patients with ST-segment elevation myocardial infarction after fibrinolysis, with reperfusion criteria, were analyzed. The mean SYNTAX score was 13.98 (±4.87) and the mean residual SYNTAX score was 7.56 (±4.47). High residual SYNTAX score was associated with contrast-induced nephropathy and major adverse cardiac event. It was also an independent predictor of major adverse cardiac event with a 9.69-fold increased risk (p=0.0274). Conclusion High residual SYNTAX score confers worse prognosis in patients with ST-segment elevation myocardial infarction after pharmacoinvasive strategy.

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Esra, Julianda* Andre P. Ketaren Zulfikri Mukhtar Ali N. Nasution &. Harris Hasan. "ASSOCIATION OF NON CHOLESTEROL HIGH DENSITY LIPOPROTEIN-TO-TOTAL CHOLESTEROL RATIO WITH SEVERITY OF CORONARY ARTERY LESION USING SYNTAX SCORE IN PATIENTS WITH ACUTE CORONARY SYNDROMES." INTERNATIONAL JOURNAL OF RESEARCH SCIENCE & MANAGEMENT 7, no. 6 (2020): 7–12. https://doi.org/10.5281/zenodo.3904136.

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Background: Coronary Artery disease (CAD) is still the leading cause of morbidity and mortality in the world. Many studies centered on the diagnosis or prognosis of CAD suggested dyslipidemia might be associated with severity of atherosclerosis. The ratio of non-HDL cholesterol to total cholesterol (non-HDL-c/TC) is a prognostic marker that combines 2 variables into one. The SYNTAX score is an anatomic scoring system based on coronary artery angiography (CAG) to quantify severity and complexity coronary lesion. The aim of this study was to investigate the association of the non-HDL-c/TC ratio with coronary artery severity using the SYNTAX score in patients with acute coronary syndrome (ACS) who underwent coronary artery angiography. Methods: Patients were recruited from June to December 2019. This cross-sectional study involved 71 patients who were admitted from the emergency department. Variables such as comorbidities, coronary artery angiography and laboratory finding were evaluated. The non-HDL-c was calculated as total cholesterol (TC) minus HDL-c, while non- HDL-c/TC was the ratio of non-HDL-c and TC. Coronary artery angiography was performed, and the SYNTAX score was calculated in all the subjects divided into two subgroups, those with low SYNTAX score (≤22) and those with high SYNTAX score (≥23). Results: a total of 71 patients with ACS who underwent CAG were included in the study from June to December 2019. From total 71 patients, there were 36 patients (50.7%) had a SYNTAX score ≥ 23 and 35 patients (49.3%) had a SYNTAX score ≤ 22. There were significant relation difference between both groups. From pearson's analysis, there was significant statistic between ratio of non-HDL/TC and SYNTAX score (r = 0.299; P value: <0.001). Conclusion: Non-HDL-c/TC ratio is significantly associated with severity of coronary lesion using SYNTAX score in patients with acute coronary syndrome.

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