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Academic literature on the topic 'Synthèse d'acides aminés hapténisés'
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Journal articles on the topic "Synthèse d'acides aminés hapténisés"
Coutrot, Ph, C. Grison, C. Gérardin-Charbonnier, and M. Lecouvey. "Synthèse dérivés insaturés d'acides α-aminés précurseurs de pseudoglycopeptides." Tetrahedron Letters 34, no. 17 (April 1993): 2767–70. http://dx.doi.org/10.1016/s0040-4039(00)73557-x.
Full textDissertations / Theses on the topic "Synthèse d'acides aminés hapténisés"
Scornet, Noémie. "Etude de l'allergie aux antibiotiques : synthèse de peptides antigéniques." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS032/document.
Full textMany drugs are responsible of allergic reactions, in particular penicillins and sulfonamides. As these antibiotics respond to the hapten theory, they cannot induce the immune system by themselves, but have to bind a protein. These haptenized proteins are detected then digested by antigen presenting cells into peptides which are presented to T cells. These haptenized peptides are responsible of the activation of the immune system in allergic patient. The aim of this study is to select and synthesize immunogenic peptides, modified by selected antibiotics. The human serum albumin (HSA) was chosen as a model protein. It haptenization was studied for three drugs with high allergic prevalence: benzylpenicillin, amoxicillin and sulfamethoxazole. Mass analysis of the resulting bioconjugates HSA-antibiotic allowed identification of haptenized amino-acid which were used to design and select through in silico methods potentially immunogenic 15-mers peptides. The synthesis of these peptides implies the preparation of stable amino-acid-hapten monomers for an oriented synthesis of diversified peptidic sequences. For penicillins, this synthesis was based on a key step: the opening of the penicillins β-lactam ring by a lysine. Regarding the sulfonamide sulfamethoxazole, the synthesis of a stable cysteine-sulfamethoxazole monomer was centered on a coupling key step between the sulfamethoxazole and a cysteic acid. From lysine-benzylpenicillin monomer, peptides have already been synthesized and tested over T cells. Their immunogenic effect and development as tools for diagnosis are being evaluated
Pham, Thi Mai Trang Catherine. "Synthèse énantiosélective d'acides Ã-aminés par l'hydrogénation catalytique." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq26716.pdf.
Full textPicard, Julien. "Synthèse d'acides aminés C-glycosylés par voie organométallique." Cergy-Pontoise, 2005. http://www.theses.fr/2005CERG0267.
Full textIn this thesis we present the synthesis of C-glycosides and of C-glycosylated amino acids according to an organometallic pathway. These compounds in which a methylene group replaces the natural N- or O-glycosilic link are particularly stable in vivo and can have enzyme inhibitors activities or can be used in the treatment of various diseases. Two synthetic approaches were studied: -The palladium-catalyzed Negishi cross-coupling. Under these conditions the desired products were not obtained; only a homocoupling product was isolated. -The indium mediated alkynylation. In this second case, various hydroxylated, ketonic, mono or di-fluorinated and methylated C-glycosides were obtained in good yields. The application of this methodology to an alkyne iodide derived from Garner's aldehyde led to C-glycosylated amino acids precursors
Milcent, Thierry. "Synthèses et applications d'acides bêta2-aminés." Paris 6, 2002. http://www.theses.fr/2002PA066260.
Full textRoby, Johanne. "Nouvelle approche de synthèse asymétrique d'acides Ã-aminés protégés." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21860.pdf.
Full textRoby, Johanne. "Nouvelle approche de synthèse asymétrique d'acides [alpha]-aminés protégés." Thèse, Université de Sherbrooke, 1996. http://savoirs.usherbrooke.ca/handle/11143/4949.
Full textHattab, Z'hour. "Synthèse d'hétérocycles phosphorylés dérivés d'acides aminés : Application à la synthèse d'antitumoraux de nouvelle génération." Paris 13, 2010. http://www.theses.fr/2010PA132033.
Full textOxazaphosphorinanes are alkylant agents used in chemotherapy but showing undesirable effects and toxicity. On the other hand, bisphosphonates are compounds used in the treatment of osteoporosis and bone metastases. They generate some side effects and have a poor bioavailability by oral absorption, due to their poor lipophilicity. Our study consisted in synthesize phosphorylated heterocycles derivated from aminoacids called oxazaphospholidinones and their coupling with bisphosphonates in order to obtain new antitumoral molecules. They could be more efficient with less undesirable effects. In a first part, we have synthesized nitrogen-protected oxazaphospholidinones from amino-alcohols. Different protective groups have been studied : benzyl, tert-butyloxycarbonyl (Boc) or benzyloxycarbonyl (Cbz). These compounds were obtained as a mixture of two diastereoisomers (P2S,C4S and P2R,C4S ; the configuration C4S was fixed by the configuration of the starting aminoacid). They were separated by column chromatography or crystallization. Diastereoisomers were characterized by IR and NMR spectroscopies and mass spectrometry and a crystallographic study was realized. In the second part, we present the deprotection of the benzyloxycarbonyl group (Cbz) and the unsuccessful hydrogenolysis or oxidation assays of benzyl group. Lastly, coupling of bisphosphonate with protected oxazaphospholidine unfortunately failed
Guibourdenche, Cristel. "Synthèse d'acides aminés neuroexcitateurs : acide quisqualique et analogues de l'acide glutamique." Montpellier 2, 1993. http://www.theses.fr/1993MON20173.
Full textBlaignon-Perbet, Christine. "Synthèse et évaluation de nouveaux agents tensioactifs F-alkylés dérivés d'acides aminés." Nice, 1987. http://www.theses.fr/1987NICE4126.
Full textJegham, Samir. "Utilisation d'acides aminés pour la synthèse énantiospécifique d'alcaloïdes indoliques, pyrrolidiniques et pipéridiniques." Paris 11, 1988. http://www.theses.fr/1988PA112322.
Full textTwo- and three-carbon homologation of suitably protected chiral2-aminoaldehydes by Wittig olefination gave the corresponding 4- and 5- aminoaldehydes without racemisation. Condensation of these amines with an indole-2-acrylic ester derivative followed by acidic treatment led, via a Diels-Alder type cycloaddition, to (+)- or (-)-20-epi-ibophy/lidine, and a mixture of (+)- and (- )-pseudovincadifformine as well as its C-20 epimer. The same protected 4- and 5- aminoaldehydes gave their corresponding di-substituted 2,5-pyrrolid. Ines d 2,6-piperidines, after Grignard chain elongation and P. C. C. Oxidation followed by N-deprotection and reductive cyclisation. The utility of this methodology was illustrated by the enantiospecific synthesis of cis and trans 2-ethyl-5-heptyl-py"olidine and 2-methyl-6-propyl-piperidine, starting from aminobutyric acid and alanine, respectively. A formal synthesis of the biologically important antibiotic (-)- and ( +)-anisomycin starting from D- and L-tyrosine, respectively, has also been described by way of a similar procedure. The possibility of extending this general methodology to the synthesis of more complex alkaloids in the indolizidine, pyrrolizidine series, etc. . . , seems to be promising