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Journal articles on the topic 'Synthèse de peptides'

Author: Grafiati

Published: 26 September 2023

Last updated: 31 July 2025

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1

Kraus, Jean Louis. "Synthèse d'azamacrocycles polysubstitués par des peptides biologiquement actifs." Journal of Heterocyclic Chemistry 22, no. 5 (1985): 1307–12. http://dx.doi.org/10.1002/jhet.5570220532.

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2

LE FLOC’H, N., and B. SEVE. "Le devenir des protéines et des acides aminés dans l’intestin du porc : de la digestion à l’apparition dans la veine porte." INRAE Productions Animales 13, no. 5 (2000): 303–14. http://dx.doi.org/10.20870/productions-animales.2000.13.5.3798.

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La digestion intestinale des protéines alimentaires fait intervenir des protéases d’origine pancréatique et des peptidases intestinales. Les produits de la digestion sont constitués d’acides aminés libres et de peptides relativement abondants. Acides aminés et peptides sont transportés dans l’entérocyte où ces derniers subissent une hydrolyse. Les acides aminés libres présents dans la veine porte présentent un profil bien différent de celui des protéines alimentaires. En effet, le métabolisme intestinal des acides aminés est très actif. Afin d’assurer la synthèse des protéines constitutives et

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3

Duvallet, Emilie, Mathilde Boulpicante, and Sébastien Apcher. "Synthèse des peptides antigéniques du CMH-I dans le noyau." médecine/sciences 30, no. 3 (2014): 229–31. http://dx.doi.org/10.1051/medsci/20143003002.

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4

Salvadori, S. "Peptides opioides: synthèse et propriétés biologiques d'hexapeptides apparents à la dermorphine." European Journal of Medicinal Chemistry 25, no. 2 (1990): 171–77. http://dx.doi.org/10.1016/0223-5234(90)90025-x.

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5

Rousseau, F., V. Fuentes, C. Corbel, E. Bissac, F. Eb, and J. Orfila. "Intérêt des peptides de synthèse dans le sérodiagnostic d'infections à Chlamydia." La Revue de Médecine Interne 17 (January 1995): S107. http://dx.doi.org/10.1016/0248-8663(96)86610-0.

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6

Michel, Andre G., Chakib Ameziane-Hassani, Gaston Boulay, and Gilles Lajoie. "Étude structurale de la liaison thioamide: Synthèse et conformation de dérivés de la thioalanine et de la thioglycine." Canadian Journal of Chemistry 67, no. 8 (1989): 1312–18. http://dx.doi.org/10.1139/v89-202.

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The present study reports the synthesis, crystal structure determinations, and the conformational analysis of N-tertiobutyloxycarbonyl N′-methylthioalanine (Boc-AlaS-NHCH3, C9H18N2O2S) and of N-tertiobutyloxycarbonyl N′-methylthioglycine (Boc-GlyS-NHCH3, C8H16N2O2S). The particular feature of these compounds is the replacement of the classical oxopeptide linkage by a thioamide bond. Crystals of Boc-AlaS-NHCH3 are tetragonal, space group P43212. Those of Boc-GlyS-NHCH3 are monoclinic, space group P21/c. Both structures were solved by direct methods and refined by full-matrix least-squares metho

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Ruzycki, Shannon Marie, and Michael Prystajecky. "Point-Counterpoint: Perioperative Cardiac Biomarkers." Canadian Journal of General Internal Medicine 14, no. 4 (2019): e14-e22. http://dx.doi.org/10.22374/cjgim.v14i4.347.

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In the following review article, we present arguments for and against the use of postoperative troponin surveillance and preoperative natriuretic peptide testing. This article covers the evidence that informed the CCS 2016 perioperative guidelines and research published since then. This review is based on the debate held at the Canadian Society of Internal Medicine/American College of Physicians Rocky Mountain Chapter Annual Meeting (CSIM/ACP RM) held in October 2018 in Banff, Alberta.  Resume Dans l'article de synthèse qui suit, nous présentons des arguments pour et contre l

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Collet, C., S. Lamandé-Langle, F. Chrétien, et al. "Synthèse de nouveaux [18F]fluoro-sucres pour le radiomarquage de peptides : application en imagerie TEP." Médecine Nucléaire 38, no. 3 (2014): 159. http://dx.doi.org/10.1016/j.mednuc.2014.03.115.

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9

Zineddine, H., M. Asso, R. Panossian, M. Guiliano, and D. Benlian. "Synthèse et structure de complexes d'ions métalliques et de peptides à résidus aspartyl et tyrosyl." Journal of Molecular Structure 192, no. 1-2 (1989): 95–106. http://dx.doi.org/10.1016/0022-2860(89)87009-7.

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10

Rauscher, A., P. Baumgartner, F. Lacoeuille, et al. "Comparaison de deux techniques de pré-purification des éluats de 68GA pour le marquage de peptides par automate de synthèse." Médecine Nucléaire 38, no. 3 (2014): 160–61. http://dx.doi.org/10.1016/j.mednuc.2014.03.120.

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11

Akomoneh, Elvis Achondou, Zina Gestels, Saïd Abdellati, et al. "Genome Mining Uncovers NRPS and PKS Clusters in Rothia dentocariosa with Inhibitory Activity against Neisseria Species." Antibiotics 12, no. 11 (2023): 1592. http://dx.doi.org/10.3390/antibiotics12111592.

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The growing global threat of antimicrobial resistance is reaching a crisis point as common bacterial infections, including those caused by pathogenic Neisseria species, are becoming increasingly untreatable. This is compelling the scientific community to search for new antimicrobial agents, taking advantage of computational mining and using whole genome sequences to discover natural products from the human microbiome with antibiotic effects. In this study, we investigated the crude extract from a Rothia dentocariosa strain with demonstrated antimicrobial activity against pathogenic Neisseria s

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12

Betsou, F., JM Sueur, C. Chaigneau, A. Gommeaux, and J. Orfila. "Des corps élémentaires aux peptides de synthèse : comparaison de techniques sérologiques utilisées pour la détection des anticorps spécifiques de Chlamydia trachomatis et Chlamydia pneumoniae." Immuno-analyse & Biologie Spécialisée 16, no. 1 (2001): 40–46. http://dx.doi.org/10.1016/s0923-2532(01)80008-9.

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13

LECLERC, Estelle, Chantal CORTI, Holger SCHMID, Stefan VETTER, Peter JAMES, and Ernesto CARAFOLI. "Serine/threonine phosphorylation of calmodulin modulates its interaction with the binding domains of target enzymes." Biochemical Journal 344, no. 2 (1999): 403–11. http://dx.doi.org/10.1042/bj3440403.

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The interaction of serine/threonine-phosphorylated calmodulin with synthetic peptides corresponding to the calmodulin-binding domains of six enzymes has been studied by fluorescence spectroscopy. For five peptides, the dissociation constant of the calmodulin-peptide complex (Kd) increased when calmodulin was phosphorylated. An increase of more than one order of magnitude was observed with peptides derived from smooth-muscle myosin light-chain kinase and cAMP phosphodiesterase. In contrast, only a slight increase in Kd was noted with two peptides derived from the plasma membrane Ca2+-ATPase and

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14

Grandi, Martina, Simone Fabbian, Giancarlo Solaini, Alessandra Baracca, Massimo Bellanda, and Valentina Giorgio. "Peptides Targeting the IF1–ATP Synthase Complex Modulate the Permeability Transition Pore in Cancer HeLa Cells." International Journal of Molecular Sciences 25, no. 9 (2024): 4655. http://dx.doi.org/10.3390/ijms25094655.

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The mitochondrial protein IF1 is upregulated in many tumors and acts as a pro-oncogenic protein through its interaction with the ATP synthase and the inhibition of apoptosis. We have recently characterized the molecular nature of the IF1–Oligomycin Sensitivity Conferring Protein (OSCP) subunit interaction; however, it remains to be determined whether this interaction could be targeted for novel anti-cancer therapeutic intervention. We generated mitochondria-targeting peptides to displace IF1 from the OSCP interaction. The use of one selective peptide led to displacement of the inhibitor IF1 fr

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15

Harken, Lauritz, and Shu-Ming Li. "Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes." Applied Microbiology and Biotechnology 105, no. 6 (2021): 2277–85. http://dx.doi.org/10.1007/s00253-021-11178-1.

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Abstract2,5-Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected via two peptide bonds. They can be biosynthesized in nature by two different enzyme families, either by nonribosomal peptide synthetases or by cyclodipeptide synthases. Due to the stable scaffold of the diketopiperazine ring, they can serve as precursors for further modifications by different tailoring enzymes, such as methyltransferases, prenyltransferases, oxidoreductases like cyclodipeptide oxidases, 2-oxoglutarate-dependent monooxygenases and cytochrome P450 enzymes, leading to the formation

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Nguyen, Tiffany T., Mourad Ogbi, Qilin Yu та John A. Johnson. "Attenuation of the hypoxia-induced protein kinase Cδ interaction with the ‘d’ subunit of F1Fo-ATP synthase in neonatal cardiac myocytes: implications for energy preservation and survival". Biochemical Journal 429, № 2 (2010): 335–45. http://dx.doi.org/10.1042/bj20091927.

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The F1Fo-ATP synthase provides most of the heart's energy, yet events that alter its function during injury are poorly understood. Recently, we described a potent inhibitory effect on F1Fo-ATP synthase function mediated by the interaction of PKCδ (protein kinase Cδ) with dF1Fo (‘d’ subunit of the F1Fo-ATPase/ATP synthase). We have now developed novel peptide modulators which facilitate or inhibit the PKCδ–dF1Fo interaction. These peptides include HIV-Tat (transactivator of transcription) protein transduction and mammalian mitochondrial-targeting sequences. Pre-incubation of NCMs (neonatal card

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17

ELOIT, M. "Vaccins traditionnels et vaccins recombinants." INRAE Productions Animales 11, no. 1 (1998): 5–13. http://dx.doi.org/10.20870/productions-animales.1998.11.1.3912.

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Différents types de vaccins sont actuellement disponibles ou en cours de développement. Ils peuvent être divisés en deux catégories : vaccins vivants et vaccins inertes. Les vaccins vivants traditionnels incluent des souches atténuées par des moyens conventionnels, comme la croissance dans des conditions de culture inhabituelles (bactéries), ou dans des cellules ou des animaux vis-à-vis desquels les souches ne sont pas initialement adaptées (virus). Les nouvelles générations de vaccins vivants utilisant les techniques de recombinaison génétique (vaccins recombinants) peuvent être fabriquées pa

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18

CHILD, J. Christopher, та Peter M. SHOOLINGIN-JORDAN. "Inactivation of the polyketide synthase, 6-methylsalicylic acid synthase, by the specific modification of Cys-204 of the β-ketoacyl synthase by the fungal mycotoxin cerulenin". Biochemical Journal 330, № 2 (1998): 933–37. http://dx.doi.org/10.1042/bj3300933.

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Cerulenin, [(2S,3R)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide], a mycotoxin produced by Cephalosporium caerulens, irreversibly inactivated 6-methylsalicylic acid synthase from Penicillium patulum. A combination of radiolabelling studies with [3H]cerulenin, proteolytic and chemical digestion and N-terminal sequencing of labelled peptides indicated that the site of cerulenin modification is the highly reactive substrate-binding Cys-204 of the β-ketoacyl synthase enzyme component. The thiol-specific inhibitor, iodoacetamide, was also shown to alkylate this residue. These findings are analogous with

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19

Jackerott, Malene, and Lars-Inge Larsson. "Immunocytochemical Localization of the NPY/PYY Y1 Receptor in Enteric Neurons, Endothelial Cells, and Endocrine-like Cells of the Rat Intestinal Tract." Journal of Histochemistry & Cytochemistry 45, no. 12 (1997): 1643–50. http://dx.doi.org/10.1177/002215549704501207.

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Neuropeptide Y (NPY) and peptide YY (PYY) are structurally related peptides that are considered to mediate inhibitory actions on gastrointestinal motility, secretion, and blood flow. Several receptor subtypes for these peptides have been identified and the Y1, Y2, Y4/PP1, Y5, and Y5/PP2/Y2b receptors have been cloned. In this article we report the immunocytochemical localization of the Y1 receptor to myenteric and submucosal nerve cell bodies, endothelial cells, and scattered endocrine-like cells of rat intestinal tract. Moreover, double immunofluorescence demonstrates that subpopulations of t

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20

Bergeron, Lindsay H., Jordan M. Willcox, Faisal J. Alibhai, et al. "Relaxin Peptide Hormones Are Protective During the Early Stages of Ischemic Stroke in Male Rats." Endocrinology 156, no. 2 (2014): 638–46. http://dx.doi.org/10.1210/en.2014-1676.

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The pregnancy hormone relaxin protects tissue from ischemic damage. The ability of relaxin-3, a relaxin paralog, to do so has not been explored. The cerebral expression levels of these peptides and their receptors make them logical targets for study in the ischemic brain. We assessed relaxin peptide-mediated protection, relative relaxin family peptide receptor (RXFP) involvement, and protective mechanisms. Sprague-Dawley rats receiving permanent (pMCAO) or transient middle cerebral artery occlusions (tMCAO) were treated with relaxin peptides, and brains were collected for infarct analysis. Act

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21

Kang, Taek Jin, and Hiroaki Suga. "Ribosomal synthesis of nonstandard peptidesThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process." Biochemistry and Cell Biology 86, no. 2 (2008): 92–99. http://dx.doi.org/10.1139/o08-009.

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It is well known that standard peptides, which comprise proteinogenic amino acids, can act as specific chemical probes to target proteins with high affinity. Despite this fact, a number of peptide drug leads have been abandoned because of their poor cell permeability and protease instability. On the other hand, nonstandard peptides isolated as natural products often exhibit remarkable pharmaco-behavior and stability in vivo. Although it is likely that numerous nonstandard therapeutic peptides capable of recognizing various targets could have been synthesized, enzymes for nonribosomal peptide s

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22

Servatius, Phil, Lukas Junk, and Uli Kazmaier. "Peptide Modifications: Versatile Tools in Peptide and Natural Product Syntheses." Synlett 30, no. 11 (2019): 1289–302. http://dx.doi.org/10.1055/s-0037-1612417.

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Peptide modifications via C–C bond formation have emerged as valuable tools for the preparation and alteration of non-proteinogenic amino acids and the corresponding peptides. Modification of glycine subunits in peptides allows for the incorporation of unusual side chains, often in a highly stereoselective manner, orchestrated by the chiral peptide backbone. Moreover, modifications of peptides are not limited to the peptidic backbone. Many side-chain modifications, not only by variation of existing functional groups, but also by C–H functionalization, have been developed over the past decade.

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23

Planas, Raquel, Radleigh Santos, Paula Tomas-Ojer, et al. "GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis." Science Translational Medicine 10, no. 462 (2018): eaat4301. http://dx.doi.org/10.1126/scitranslmed.aat4301.

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Multiple sclerosis is an immune-mediated autoimmune disease of the central nervous system that develops in genetically susceptible individuals and likely requires environmental triggers. The autoantigens and molecular mimics triggering the autoimmune response in multiple sclerosis remain incompletely understood. By using a brain-infiltrating CD4+ T cell clone that is clonally expanded in multiple sclerosis brain lesions and a systematic approach for the identification of its target antigens, positional scanning peptide libraries in combination with biometrical analysis, we have identified guan

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Pacifico, Salvatore, Matteo Santucci, Rosaria Luciani, et al. "Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth." Molecules 24, no. 19 (2019): 3493. http://dx.doi.org/10.3390/molecules24193493.

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Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In the effort to identify anti-TS drugs with new modes of action and able to overcome platinum drug resistance in ovarian cancer, octapeptides with a new allosteric inhibition mechanism were identified as cancer cell growth inhibitors that do not cause TS overexpression. To improve the biological properties, 10 cyclic peptides (cPs) were designed from

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Bendlová, Běla, Michal Lebl, Pavel Štolba, and Luboslav Stárka. "Synthesis of modified human C-peptide and its fragments." Collection of Czechoslovak Chemical Communications 53, no. 11 (1988): 2637–44. http://dx.doi.org/10.1135/cccc19882637.

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Syntheses of the modified human C-peptide containing residues suitable for the introduction of the radioactive label (tyrosine) and internal marker for monitoring binding to carrier (norvaline) and five of its fragments are described. The syntheses were performed by solid phase method using either 9-fluorenylmethoxycarbonyl or tert-butyloxycarbonyl protecting groups. The products were purified by gel filtration, ion exchange chromatography and reversed phase HPLC. The reactivity of prepared peptides with antisera was determined and the modified C-peptide was found fully reactive.

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Chu, Yin-Hung, Wen-Chieh Liao, Ying-Jui Ho, Chih-Hsien Huang, To-Jung Tseng та Chiung-Hui Liu. "Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression". Cells 10, № 12 (2021): 3594. http://dx.doi.org/10.3390/cells10123594.

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Chondroitin sulfate (CS) is a major component of the extracellular matrix found to be abnormally accumulated in several types of cancer tissues. Previous studies have indicated that CS synthases and modification enzymes are frequently elevated in human gliomas and are associated with poor prognosis. However, the underlying mechanisms of CS in cancer progression and approaches for interrupting its functions in cancer cells remain largely unexplored. Here, we have found that CS was significantly enriched surrounding the vasculature in a subset of glioma tissues, which was akin to the perivascula

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Kohlbaua, Hans-Jürgen, Jochen Tschakert, Raed A. Al-Qawasmeh, Tanveer Ahmad Nizamì, Abdul Malik, and Wolfgang Voelter. "Festphasensynthese von Muramyldipeptiden an isomeren Trialkoxybenzylamin-Harzen / Solid Phase Synthesis of Muramyl Dipeptides on Isomeric Trialkoxybenzylamine Resins." Zeitschrift für Naturforschung B 53, no. 7 (1998): 753–64. http://dx.doi.org/10.1515/znb-1998-0716.

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Abstract New isomeric trialkoxybenzylamine resins are developed coupling phthalimidomethyl-3,5-dimethoxyphenols to the Merrifield resin, followed by subsequent treatment with hydrazine. The generated benzylamine function allows DCC coupling w ith the carboxyl function of amino acids and peptides which are removed as amides after treatment with trifluoroacetic acid. These new trialkoxybenzylamine resins allow expeditious syntheses of peptide amides and glycopeptide amides as is demonstrated for muramyl peptides and analogues.

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Moolhuijzen, Paula M., Mariano Jordi Muria-Gonzalez, Robert Syme, et al. "Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp." Toxins 12, no. 4 (2020): 242. http://dx.doi.org/10.3390/toxins12040242.

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Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM) within Pyrenophora pathogenic species remains mostly uncharted. In this study, an in-depth comparative analysis of the P. teres f. teres, P teres f. maculata and P. tritici-repentis potential to produce SMs, based on in silico predicted biosynthetic gene clusters (BGCs), was conducted using genome assemblies from PacBio DNA reads. Conservation

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Čeřovský, Václav, and Maria‐Regina Kula. "Studies on peptide amidase‐catalysed C‐terminal peptide amidation in organic media with respect to its substrate specificity." Biotechnology and Applied Biochemistry 33, no. 3 (2001): 183–87. http://dx.doi.org/10.1111/j.1470-8744.2001.tb00925.x.

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Peptide amidase‐catalysed amidations of the C‐ terminal carboxylic group of peptides were studied using model substrates of a large series of Nα‐protected di‐, tri‐, tetra‐ and penta‐peptides in the presence of NH4HCO3 as the ammonium source. The maximal yields of amide syntheses were achieved in a medium consisting of acetonitrile with 20–25 vol% of dimethylformamide and 3 vol% of water. Under these conditions, the substrate specificity of the enzyme was more restricted in the synthetic reaction than was found for the amide hydrolysis. Elongation of the peptide chain had a negative effect on

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Dubois, Damien, Olivier Baron, Antony Cougnoux, et al. "ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides." Journal of Biological Chemistry 286, no. 41 (2011): 35562–70. http://dx.doi.org/10.1074/jbc.m111.221960.

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The pks genomic island of Escherichia coli encodes polyketide (PK) and nonribosomal peptide (NRP) synthases that allow assembly of a putative hybrid PK-NRP compound named colibactin that induces DNA double-strand breaks in eukaryotic cells. The pks-encoded machinery harbors an atypical essential protein, ClbP. ClbP crystal structure and mutagenesis experiments revealed a serine-active site and original structural features compatible with peptidase activity, which was detected by biochemical assays. Ten ClbP homologs were identified in silico in NRP genomic islands of closely and distantly rela

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Hughes, S. J., H. Smith, and S. J. H. Ashcroft. "Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets." Biochemical Journal 289, no. 3 (1993): 795–800. http://dx.doi.org/10.1042/bj2890795.

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We have attempted to identify islet Ca2+/calmodulin-dependent protein kinase (CaM kinase) by comparing its activity with purified brain CaM kinase II. Islet CaM kinase, in the presence of calmodulin and Ca2+, phosphorylated major endogenous substrates of 102, 57 and 53 kDa and also exogenous glycogen synthase; brain CaM kinase II phosphorylated glycogen synthase and peptides of 57 and 53 kDa. Alloxan (1 mM) inhibited the phosphorylation of glycogen synthase and the 102, 57 and 53 kDa islet peptides by islet CaM kinase; the phosphorylation of glycogen synthase and the 57 and 53 kDa substrates b

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Lee, Bee-Na, Scott Kroken, David Y. T. Chou, Barbara Robbertse, O. C. Yoder, and B. Gillian Turgeon. "Functional Analysis of All Nonribosomal Peptide Synthetases in Cochliobolus heterostrophus Reveals a Factor, NPS6, Involved in Virulence and Resistance to Oxidative Stress." Eukaryotic Cell 4, no. 3 (2005): 545–55. http://dx.doi.org/10.1128/ec.4.3.545-555.2005.

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ABSTRACT Nonribosomal peptides, made by nonribosomal peptide synthetases, have diverse biological activities, including roles as fungal virulence effectors. Inspection of the genome of Cochliobolus heterostrophus, a fungal pathogen of maize and a member of a genus noted for secondary metabolite production, revealed eight multimodular nonribosomal peptide synthase (NPS) genes and three monomodular NPS-like genes, one of which encodes a nonribosomal peptide synthetase/polyketide synthase hybrid enzyme presumed to be involved in synthesis of a peptide/polyketide molecule. Deletion of each NPS gen

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Goettig, Peter. "Reversed Proteolysis—Proteases as Peptide Ligases." Catalysts 11, no. 1 (2020): 33. http://dx.doi.org/10.3390/catal11010033.

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Historically, ligase activity by proteases was theoretically derived due to their catalyst nature, and it was experimentally observed as early as around 1900. Initially, the digestive proteases, such as pepsin, chymotrypsin, and trypsin were employed to perform in vitro syntheses of small peptides. Protease-catalyzed ligation is more efficient than peptide bond hydrolysis in organic solvents, representing control of the thermodynamic equilibrium. Peptide esters readily form acyl intermediates with serine and cysteine proteases, followed by peptide bond synthesis at the N-terminus of another re

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Tsibulnikov, Sergey Y., Leonid N. Maslov, Alexander S. Gorbunov, et al. "A Review of Humoral Factors in Remote Preconditioning of the Heart." Journal of Cardiovascular Pharmacology and Therapeutics 24, no. 5 (2019): 403–21. http://dx.doi.org/10.1177/1074248419841632.

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A humoral mechanism of cardioprotection by remote ischemic preconditioning (RIP) has been clearly demonstrated in various models of ischemia–reperfusion including upper and lower extremities, liver, and the mesenteric and renal arteries. A wide range of humoral factors for RIP have been proposed including hydrophobic peptides, opioid peptides, adenosine, prostanoids, endovanilloids, endocannabinoids, calcitonin gene-related peptide, leukotrienes, noradrenaline, adrenomedullin, erythropoietin, apolipoprotein, A-I glucagon-like peptide-1, interleukin 10, stromal cell-derived factor 1, and microR

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Hebecker, Stefanie, Joern Krausze, Tatjana Hasenkampf, et al. "Structures of two bacterial resistance factors mediating tRNA-dependent aminoacylation of phosphatidylglycerol with lysine or alanine." Proceedings of the National Academy of Sciences 112, no. 34 (2015): 10691–96. http://dx.doi.org/10.1073/pnas.1511167112.

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The cytoplasmic membrane is probably the most important physical barrier between microbes and the surrounding habitat. Aminoacylation of the polar head group of the phospholipid phosphatidylglycerol (PG) catalyzed by Ala-tRNAAla–dependent alanyl-phosphatidylglycerol synthase (A-PGS) or by Lys-tRNALys–dependent lysyl-phosphatidylglycerol synthase (L-PGS) enables bacteria to cope with cationic peptides that are harmful to the integrity of the cell membrane. Accordingly, these synthases also have been designated as multiple peptide resistance factors (MprF). They consist of a separable C-terminal

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Brinkworth, Craig S., Tara L. Pukala, John H. Bowie, and Michael J. Tyler. "Host Defence Peptides from the Skin Glands of Australian Amphibians. Caerulein Neuropeptides and Antimicrobial, Anticancer, and nNOS Inhibiting Citropins from the Glandular Frog Litoria subglandulosa." Australian Journal of Chemistry 57, no. 7 (2004): 693. http://dx.doi.org/10.1071/ch03325.

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The host defence peptides from the skin secretions of the Australian Glandular Frog (Litoria subglandulosa) are similar to those of the closely related species Litoria citropa. Both species produce several potent caerulein neuropeptides and antimicrobial- and anticancer-active citropin peptides. The major neuropeptides from Litoria subglandulosa are caerulein 1.1 [pGlu Gln Asp Tyr(SO3) Thr Gly Trp Met Asp Phe–NH2], caerulein 1.2 [pGlu Gln Asp Tyr(SO3) Thr Gly Trp Phe Asp Phe–NH2], and caerulein 2.1 [pGlu Gln Asp Tyr(SO3) Thr Gly Ala His Met Phe–NH2], all of which are smooth muscle active. The

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Basilicata, Manuela Giovanna, Giacomo Pepe, Shara Francesca Rapa, et al. "Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells." International Journal of Molecular Sciences 20, no. 23 (2019): 6087. http://dx.doi.org/10.3390/ijms20236087.

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Inflammation and oxidative stress are always more recognized as responsible for chronic disease at the intestinal level. Currently, a growing interest is addressed to the discovery of diet-derived products which have anti-inflammatory and antioxidant properties. This work aims to characterize the pharmacological potential of dehydrated potatoes. For this purpose, a simulated gastrointestinal digestion was carried out. The bioaccessible peptides were fractionated on the basis of their molecular weight and tested on intestinal epithelial cells (IEC-6) under oxidative and inflammatory conditions.

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Suring, Wouter, Dylan Hoogduin, Giang Le Ngoc, Abraham Brouwer, Nico M. van Straalen, and Dick Roelofs. "Nonribosomal Peptide Synthetases in Animals." Genes 14, no. 9 (2023): 1741. http://dx.doi.org/10.3390/genes14091741.

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Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals. Recently, several novel NRPS genes have been described in nematodes, schistosomes, and arthropods, which led us to investigate how prevalent NRPS genes are in the animal kingdom. We screened 1059 sequenced animal genomes and showed that NRPSs were present in 7 out of the 19 phyla analyzed. A phylogenetic analysis showed that th

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Hayashi, Yukimasa, Chiaki W. Nakagawa, Duangchan Uyakul, Kunio Imai, Minoru Isobe, and Toshio Goto. "The change of cadystin components in Cd-binding peptides from the fission yeast during their induction by cadmium." Biochemistry and Cell Biology 66, no. 4 (1988): 288–95. http://dx.doi.org/10.1139/o88-038.

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Previously we reported that, upon exposure to Cd, Cd-bindimg peptides (Cd-BP1 and Cd-BP2) were induced in the fission yeast and that these Cd-BPs were composed of Cd atoms and multiples of the unit peptide cadystin. In this paper, the changes of relative amounts of cadystin species in each Cd-BP were determined during their induction by Cd in the logarithmically growing yeast. The preferential syntheses of the smaller cadystin species, in the early stages of induction by Cd and of the larger cadystin species at the late stage of induction suggested the biosynthetic pathway of cadystins in the

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Choi, Soyun, Sohee Han, Seungmi Lee, Jongmin Kim, Jinho Kim, and Dong-Ku Kang. "Synergistic Antioxidant and Anti-Inflammatory Effects of Phenolic Acid-Conjugated Glutamine–Histidine–Glycine–Valine (QHGV) Peptides Derived from Oysters (Crassostrea talienwhanensis)." Antioxidants 13, no. 4 (2024): 447. http://dx.doi.org/10.3390/antiox13040447.

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The glutamine–histidine–glycine–valine (QHGV), a peptide derived from oysters, exhibits antioxidant activity and is being actively researched as a potential pharmaceutical and functional cosmetic ingredient. In this study, we synthesized the QHGV peptide and explored the hitherto unknown anti-inflammatory effects of QHGV. The antioxidant property was also characterized by conjugating with various naturally derived phenolic acids, such as caffeic, gallic, ferulic, sinapinic, and vanillic acids. Conjugation with phenolic acids not only enhanced the antioxidant activity of QHGV but also diminishe

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Khavinson, Vladimir Khatskelevich, Irina Grigor’evna Popovich, Natalia Sergeevna Linkova, Ekaterina Sergeevna Mironova, and Anastasiia Romanovna Ilina. "Peptide Regulation of Gene Expression: A Systematic Review." Molecules 26, no. 22 (2021): 7053. http://dx.doi.org/10.3390/molecules26227053.

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Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems. The mechanism of such action of peptides involves their ability to regulate gene expression and protein synthesis in plants, microorganisms, insects, birds, rodents, primates, and humans. Short peptides, consisting of 2–7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA–peptide interactions, including sequence recognition in gene

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Guo, Yu, Jia Zhang, Ji-Cheng Wang, et al. "Identification of Peptides Inhibiting Adhesion of Monocytes to the Injured Vascular Endothelial Cells through Phage-displaying Screening." Acta Biochimica et Biophysica Sinica 37, no. 4 (2005): 227–33. http://dx.doi.org/10.1111/j.1745-7270.2005.00039.x.

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AbstractUsing oxidized low-density lipoprotein (LDL)-injured vascular endothelial cells (ECs) as target cells, peptides specifically binding to the injured ECs were screened from a phage-displaying peptide library by using the whole-cell screening technique after three cycles of the “adsorption-elution-amplification” procedure. Positive phage clones were identified by ELISA, and the inserted amino acid sequences in the displaying peptides were deduced from confirmation with DNA sequencing. The adhesion rate of ECs to monocytes was evaluated by cell counting. The activity of endothelial nitric

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Eckert, Heiner, Barbara Forster, and Christoph Seidel. "Vollständige Maskierung der –Gly-Bindungen mit dem stark lipophilen und chromophoren Ferrocenylmethyl[Fem]-Rest bei Peptidsynthesen von Hexaglycin und Leu-Enkephalin / Total Masking –Gly Bonds by Highly Lipophilic and Chromophoric Ferrocenylmethyl [Fem] Residue in Peptide Syntheses of Hexaglycine and Leu-Enkephalin." Zeitschrift für Naturforschung B 46, no. 3 (1991): 339–52. http://dx.doi.org/10.1515/znb-1991-0314.

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Highly lipophilic and chromophoric ferrocenylmethyl [Fem] residue is applied to syntheses of peptides hexaglycine and Leu-enkephalin, masking therein all –Gly bonds. Thereby Fem groups influence properties of Fem-peptide derivatives advantageously both in chemosyntheses and cleaning operations, leading to constantly high yields et each step. Despite of its volumous dimension the Fem residue can be introduced into each peptide bond of oligoglycine by succeeding one another of building blocks of H–Fem–Gly–OMe. Strong alkaline conditions during the hydrolyses of methyl esters occurring several ti

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Ribeiro, Ana R. M., Helena P. Felgueiras, Susana P. G. Costa, and Sílvia M. M. A. Pereira-Lima. "Synthesis of Peptaibolin, an Antimicrobial Peptide." Proceedings 78, no. 1 (2020): 47. http://dx.doi.org/10.3390/iecp2020-08654.

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To tackle one of the biggest global health problems, the resistance of microorganisms to antibiotics, a collective effort in the search for more effective agents against bacteria was required. Peptides with antimicrobial activity have been raising much attention as a promising alternative for antibiotics. Peptaibols, for instance, are a family of antimicrobial peptides (AMPs) with great biomedical potential, in which the Peptaibolin can be highlighted. This peptide has gained relevance due to its small amino acids content, only four, and its acetyl group and a phenylalaninol residue (Phol) at

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Carabaza, A., J. Arino, J. W. Fox, C. Villar-Palasi, and J. J. Guinovart. "Purification, characterization and partial amino acid sequence of glycogen synthase from Saccharomyces cerevisiae." Biochemical Journal 268, no. 2 (1990): 401–7. http://dx.doi.org/10.1042/bj2680401.

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Glycogen synthase from Saccharomyces cerevisiae was purified to homogeneity. The enzyme showed a subunit molecular mass of 80 kDa. The holoenzyme appears to be a tetramer. Antibodies developed against purified yeast glycogen synthase inactivated the enzyme in yeast extracts and allowed the detection of the protein in Western blots. Amino acid analysis showed that the enzyme is very rich in glutamate and/or glutamine residues. The N-terminal sequence (11 amino acid residues) was determined. In addition, selected tryptic-digest peptides were purified by reverse-phase h.p.l.c. and submitted to ga

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Hati, Dian Laksamana, Sri Andarini, Dian Handayani, Djalal Rosyidi, and Lilik Eka Radiati. "Characterization and Production of Goat Milk Kefir-Peptide on Triglyceride Synthesis of Cell Model of 3T3-L1." Jurnal Ilmu dan Teknologi Hasil Ternak 18, no. 1 (2023): 1–11. http://dx.doi.org/10.21776/ub.jitek.2023.018.01.1.

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Goat milk kefir (GMK) refers to fermented products, generated through fermenting milk with microbial culture called kefir grains. Prior studies have reported the changes in kefir quality properties during aging process in which fermentation continues, resulting in changes of the peptide content. This research aims to investigate the effect of aging time on GMK–peptide characteristics to inhibite triglyceride syntheses on cells model of 3T3-L1. In this study, GMK were stored at 4 ± 1 oC for 0, 2, 4, 6 and 8 weeks, respectively. The protein profile was characterizedby implementing SDS-PAGE. The

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Komaki, Hisayuki, and Tomohiko Tamura. "Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in Type Strains of the Genus Phytohabitans." Life 10, no. 11 (2020): 257. http://dx.doi.org/10.3390/life10110257.

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(1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites. Polyketide and nonribosomal peptide compounds are major secondary metabolites in actinomycetes and expected as a potential source for novel pharmaceuticals. (2) Methods: Whole genomes of Phytohabitans flavus NBRC 107702T, Phytohabitans rumicis NBRC 108638T, Phytohabitans houttuyneae NBRC 108639T, and Phytohabitans suffuscus NBRC 105367T were sequenced by PacBio. Polyketide synthase (PKS) and nonribosomal

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Overlingė, Donata, Marta Cegłowska, Robert Konkel, and Hanna Mazur-Marzec. "Aeruginosin 525 (AER525) from Cyanobacterium Aphanizomenon Sp. (KUCC C2): A New Serine Proteases Inhibitor." Marine Drugs 22, no. 11 (2024): 506. http://dx.doi.org/10.3390/md22110506.

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Aeruginosins (AERs) are one of the most common classes of cyanobacterial peptides synthesised through a hybrid non-ribosomal peptide synthase/polyketide synthase pathway. They have been found in Microcystis, Nodularia spumigena, Oscillatoria/Plantothrix, and Nostoc. The presence of AER in Aphanizomenon isolated from the Curonian Lagoon was reported for the first time in our previous work. Here, the structure of aeruginosin 525 (AER525), isolated from Aphanizomenon sp. KUCC C2, was characterised based on high-resolution mass spectrometry. This new AER variant shows potent activity against throm

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Neilan, Brett A., Elke Dittmann, Leo Rouhiainen, et al. "Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria." Journal of Bacteriology 181, no. 13 (1999): 4089–97. http://dx.doi.org/10.1128/jb.181.13.4089-4097.1999.

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ABSTRACT Nonribosomal peptide synthesis is achieved in prokaryotes and lower eukaryotes by the thiotemplate function of large, modular enzyme complexes known collectively as peptide synthetases. These and other multifunctional enzyme complexes, such as polyketide synthases, are of interest due to their use in unnatural-product or combinatorial biosynthesis (R. McDaniel, S. Ebert-Khosla, D. A. Hopwood, and C. Khosla, Science 262:1546–1557, 1993; T. Stachelhaus, A. Schneider, and M. A. Marahiel, Science 269:69–72, 1995). Most nonribosomal peptides from microorganisms are classified as secondary

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Huo, Li-Jie, Peng-Yuan Lu, Dian-Xiang Li, and Xiu-Zhen Shi. "The sORF-Encoded Peptides, ATP Synthase Subunits, Facilitate WSSV Duplication in Shrimp." Viruses 14, no. 11 (2022): 2449. http://dx.doi.org/10.3390/v14112449.

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Short open reading frames (sORFs) are a newly identified family of genes, and the functions of most sORF genes and their encoded peptides (SEPs) are still unknown. In this study, two ATP synthase subunits were identified in kuruma shrimp (Marsupenaeus japonicus) as SEPs, namely MjATP5I and MjATP5L. They were widely distributed in all of the tested tissues of shrimp and upregulated in hemocytes and intestines in response to WSSV challenge. The injection of recombinant proteins (rMjATP5I and rMjATP5L) increased the expression of Ie1 and Vp28, while the knockdown of MjATP5I and MjATP5L decreased

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