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Journal articles on the topic 'Synthèse HP'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Pelaprat, N., C. Brondino, G. Rigal, and B. Boutevin. "Synthèse d'alkylphosphonates à longues chaines hydrocarbonées, modifications chimiques et applications—II. Addition de HP(O)(OEt)2 sur les alcènes et phosphonation directe d'halogénures d'alkyles." European Polymer Journal 32, no. 6 (1996): 761–66. http://dx.doi.org/10.1016/0014-3057(95)00189-1.

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2

Zhu, Hongming, Aijun Sun, Yunzeng Zou, and Junbo Ge. "Inducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia." Arteriosclerosis, Thrombosis, and Vascular Biology 34, no. 4 (2014): 870–76. http://dx.doi.org/10.1161/atvbaha.114.303194.

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Objective— Ischemic tissue is an environment with limited oxygen and nutrition availability. The poor retention of mesenchymal stem cells (MSC) in ischemic tissues greatly limits their therapeutic potential. The aim of this study was to determine whether and how inducible metabolic adaptation enhances MSC survival and therapy under ischemia. Approach and Results— MSC were subjected to glycogen synthase 1–specific small interfering RNA or vehicle treatment, and then sublethal hypoxic preconditioning (HP) was applied to induce glycogenesis. The treated cells were subjected to ischemic challenge.

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Wang, Li, Yuan Zhou, Jun Peng, Zhe Zhang, De-Jian Jiang, and Yuan-Jian Li. "Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury." Canadian Journal of Physiology and Pharmacology 86, no. 3 (2008): 97–104. http://dx.doi.org/10.1139/y08-003.

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To explore the role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) in gastric mucosal injury, 3 models of gastric mucosal injury induced by ethanol, indomethacin, or cold stress were used in rats. The cultured human gastric mucosal epithelial cell line GES-1 infected by Helicobacter pylori (Hp) was selected to mimic human gastric mucosal injury. Gastric mucosal ulcer index (UI), levels of ADMA and NO, and activity of dimethylarginine dimethylaminohydrolase (DDAH) were determined in the mucosal injury models; in Hp-infected or ADMA-treated GES-1 cells

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4

Hoque, Sanzana, Yuki Kondo, Nodoka Sakata, et al. "Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells." International Journal of Molecular Sciences 21, no. 3 (2020): 898. http://dx.doi.org/10.3390/ijms21030898.

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Niemann–Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC treatment, and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic oligosaccharide derivative, is being developed to treat NPC. Moreover, therapeutic potential of 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was shown in NPC models, although its mechanism of action remains unclear. Here, we investigated the effects of HP-β-CD, HP-γ-CD, and their homolog 2-hyd

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Plotnikova, Ekaterina Yu, Lyubov A. Yaroshenko, and Alyona O. Kutsaeva. "Nitric oxide system in patients infected with Helicobacter pylori of different genotypes." Clinical review for general practice 4, no. 1 (2023): 49–52. http://dx.doi.org/10.47407/kr2023.4.1.00189.

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Introduction. Helicobacter pylori (Hp) is a class I biological carcinogen and the third leading cause of cancer death in the world, according to the World Health Organization. Hp infection represents a global public health problem in the 4.4 billion people living with Hp worldwide. The pathogenesis of helicobacteriosis is multifaceted: disorders in the nitric oxide (NO) system are involved in the development of the disease, along with other mechanisms. These aspects of the pathogenesis of helicobacteriosis are not well understood. In particular, such parts of the general problem as the signifi

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Doherty, Neil C., Feifei Shen, Nigel M. Halliday, et al. "In Helicobacter pylori, LuxS Is a Key Enzyme in Cysteine Provision through a Reverse Transsulfuration Pathway." Journal of Bacteriology 192, no. 5 (2010): 1184–92. http://dx.doi.org/10.1128/jb.01372-09.

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ABSTRACT In many bacteria, LuxS functions as a quorum-sensing molecule synthase. However, it also has a second, more central metabolic function in the activated methyl cycle (AMC), which generates the S-adenosylmethionine required by methyltransferases and recycles the product via methionine. Helicobacter pylori lacks an enzyme catalyzing homocysteine-to-methionine conversion, rendering the AMC incomplete and thus making any metabolic role of H. pylori LuxS (LuxSHp) unclear. Interestingly, luxS Hp is located next to genes annotated as cysK Hp and metB Hp, involved in other bacteria in cysteine

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Shih, Jui-Hu, Yow-Fu Tsai, I.-Hsun Li, Ming-Hua Chen та Yuahn-Sieh Huang. "Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells". Marine Drugs 18, № 10 (2020): 496. http://dx.doi.org/10.3390/md18100496.

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Hp-s1 ganglioside is isolated from the sperm of sea urchin (Hemicentrotus pulcherrimus). In addition to neuritogenic activity, the biological function of Hp-s1 in neuroinflammation is unknown. In this study, we investigated the anti-neuroinflammatory effect of Hp-s1 on lipopolysaccharide (LPS)-stimulated microglial cells. MG6 microglial cells were stimulated with LPS in the presence or absence of different Hp-s1 concentrations. The anti-inflammatory effect and underlying mechanism of Hp-s1 in LPS-activated microglia cells were assessed through a Cell Counting kit-8 assay, Western blot analysis

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Liu, Jie, Irene Ginis, Maria Spatz та John M. Hallenbeck. "Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-α and ceramide". American Journal of Physiology-Cell Physiology 278, № 1 (2000): C144—C153. http://dx.doi.org/10.1152/ajpcell.2000.278.1.c144.

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Brief “preconditioning” ischemia induces ischemic tolerance (IT) and protects the animal brain from subsequent otherwise lethal ischemia. Identification of the signaling steps most proximal to the development of the IT will allow induction of the resistance to ischemia shortly after the onset of stroke. Animal studies demonstrate a key role of tumor necrosis factor-α (TNF-α) in induction of IT. The sphingolipid ceramide is known as a second messenger in many of the multiple effects of TNF-α. We hypothesized that ceramide could mediate IT. We demonstrate that preconditioning of rat cortical neu

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9

Niepolski, Leszek, and Kamila Malinowska-Loba. "Association of Circulating Endothelial Nitric Oxide Synthase Levels with Phosphataemia in Patients on Haemodialysis." Biomedicines 12, no. 3 (2024): 687. http://dx.doi.org/10.3390/biomedicines12030687.

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The amount of evidence indicates that hyperphosphataemia (HP) can induce endothelial damage and significantly impair endothelial nitric oxide synthase (eNOS) expression. There are no clinical studies that have assessed HP and its correlation with circulating eNOS concentration in patients with end-stage renal disease (ESRD). Our preliminary study aimed to evaluate the relationship between plasma inorganic phosphorus (P) levels and circulating plasma eNOS concentration in patients on haemodialysis (HD). A total of 50 patients on HD were enrolled to the study. They were divided into groups accor

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10

Huang, Ho-Shiang, Ming-Chieh Ma, and Jun Chen. "Chronic l-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition." American Journal of Physiology-Renal Physiology 295, no. 2 (2008): F388—F396. http://dx.doi.org/10.1152/ajprenal.00405.2007.

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Hyperoxaluric kidneys show an impaired diuretic response to acute infusion of l-arginine. In this study, we examined the chronic effect of l-arginine supplementation on CaOx crystal formation in hyperoxaluric rat kidneys. Eight groups were tested: control (received drinking water), L group (received l-arginine, 0.6%), LN group [received NG-nitro-l-arginine methyl ester (l-NAME, 10 mg/kg)], L + LN group (received l-arginine + l-NAME), HP group [received hydroxyl-l-proline (HP, 5%) mixed with chow to induce hyperoxaluria], L + HP group (received HP + l-arginine), HP + LN group, and L + HP + LN g

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Duin, Stam, Uitterdijk, et al. "Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis." Journal of Clinical Medicine 8, no. 8 (2019): 1204. http://dx.doi.org/10.3390/jcm8081204.

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Pulmonary hypertension (PH) as a result of pulmonary vein stenosis (PVS) is extremely difficult to treat. The ideal therapy should not target the high-pressure/low-flow (HP/LF) vasculature that drains into stenotic veins, but only the high-pressure/high-flow (HP/HF) vasculature draining into unaffected pulmonary veins, reducing vascular resistance and pressure without risk of pulmonary oedema. We aimed to assess the activity of the nitric oxide (NO) pathway in PVS during the development of PH, and investigate whether interventions in the NO pathway differentially affect vasodilation in the HP/

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SARIYILDIZ, Aylin, Halil Mahir KAPLAN, Ergin ŞİNGİRİK, and Erkan KOZANOGLU. "Hypericum perforatum ekstresinin siyatik sinir hasarı ile indüklenen periferik nöropati üzerindeki düzenleyici etkisi: fareler üzerinde deneysel bir çalışma." Cukurova Medical Journal 48, no. 2 (2023): 513–21. http://dx.doi.org/10.17826/cumj.1259761.

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Purpose: The effect of Hypericum perforatum (HP), which is a medicinal plant, on sciatic nerve injury-induced peripheral neuropathy has been less studied so far. The current experimental study aimed to investigate the neuroprotective and antinociceptive effects of Hypericum perforatum (HP) extract on sciatic nerve injury-induced peripheral neuropathy in mice. Materials and Methods: In the present study, 18 Balb/C albino mice were allocated equally into three groups. The first group was determined as controls, and no procedure was performed on these mice. Neuropathy was generated by the p

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13

Choi, Sung-Won, Dong-Hoon Bai, Ju-Hyun Yu, and Chul Soo Shin. "Characteristics of the squalene synthase inhibitors produced by a Streptomyces species isolated from soils." Canadian Journal of Microbiology 49, no. 11 (2003): 663–68. http://dx.doi.org/10.1139/w03-084.

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Microorganisms producing squalene synthase inhibitors were screened from soils. A high producer was selected and identified as a Streptomyces species. Two active inhibitors were obtained from culture broths via a series of purification processes involving solvent extraction, WK-10 cation-exchange column chromatography, HP-20 adsorption column chromatography, silica-gel column chromatography, preparative HPLC, and crystallization. The inhibitors were confirmed as macrolactins A and F with molecular weights of 402 by UV-absorption spectrometry, fast atom bombardment mass spectometry, and 13C- an

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Thomas, D. P., R. J. McCormick, S. D. Zimmerman, R. K. Vadlamudi, and L. E. Gosselin. "Aging- and training-induced alterations in collagen characteristics of rat left ventricle and papillary muscle." American Journal of Physiology-Heart and Circulatory Physiology 263, no. 3 (1992): H778—H783. http://dx.doi.org/10.1152/ajpheart.1992.263.3.h778.

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We evaluated the single and interactive effects of aging and exercise training on selected parameters of myocardial interstitium in both the left ventricle (LV) and LV papillary muscle of female Fischer 344 specific pathogen-free rats. Ten weeks of treadmill running resulted in significant LV hypertrophy as well as elevated plantaris muscle citrate synthase activity in both young adult (5-mo-old) and senescent (23-mo-old) trained animals (YT, young trained; OT, old trained) compared with age-matched sedentary controls (YC, young control; OC, old control). Proline and hydroxyproline pools were

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15

Vieira, F., J. Kang, L. Ferreira, and S. Mizuno. "Hydrostatic pressure mimicking diurnal spinal movements maintains anabolic turnover in bovine nucleus pulposus cells in vitro." European Cells and Materials 42 (October 7, 2021): 246–63. http://dx.doi.org/10.22203/ecm.v042a18.

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Treatment strategies for progressive intervertebral-disc degeneration often alleviate pain and other symptoms. With the goal of developing strategies to promote the regeneration of the nucleus pulposus (NP), the present study tried to identify the biological effects of hydrostatic (HP) and osmotic pressures on NP cells. The study hypothesis was that a repetitive regimen of cyclic HP followed by constant HP in high-osmolality medium would increase anabolic molecules in NP cells. Bovine NP cells/clusters were enclosed within semi-permeable membrane pouches and incubated under a regimen of cyclic

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16

Abuduli, Maerjianghan, Hirokazu Ohminami, Tamaki Otani, et al. "Effects of dietary phosphate on glucose and lipid metabolism." American Journal of Physiology-Endocrinology and Metabolism 310, no. 7 (2016): E526—E538. http://dx.doi.org/10.1152/ajpendo.00234.2015.

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Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi (LP)],

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17

Daniel, Andrea R., Chang-Lung Lee, Patrick Oh, Lixia Luo, Yan Ma, and David G. Kirsch. "Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice." Health Physics 119, no. 3 (2020): 315–21. http://dx.doi.org/10.1097/hp.0000000000001243.

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18

Gallardo, M., I. Sanchez-Calle, PMD Rueda, and AJ Matilla. "Alleviation of Thermoinhibition in Chickpea Seeds by Putrescine Involves the Ethylene Pathway." Functional Plant Biology 23, no. 4 (1996): 479. http://dx.doi.org/10.1071/pp9960479.

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Germination of chickpea (Cicer arietinum L.) was inhibited by supraoptimal temperatures of 30 or 35�C, but the inhibition was alleviated by a relatively low concentration (1 mM) of putrescine (Put). This allevation may be due to (a) stimulation of the 1-aminocyclopropane-1-carboxylate (ACC) synthase and ACC oxidase activities; (b) increased levels of ACC and decreased levels of 1-(malonylamino)cyclopropane-1-carboxylic acid (MACC); or (c) strongly increased ethylene production. Put at 10 mM did not alleviate thermoinhibition, although, as with Put at 1 mM, it did inhibit adenosyl-methionine (A

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Skouloubris, Stéphane, Kamel Djaout, Isabelle Lamarre, et al. "Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones." Open Biology 5, no. 6 (2015): 150015. http://dx.doi.org/10.1098/rsob.150015.

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ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori , based on our earlier biochemical and structural analyses, we designed a series of eighteen 2-hydroxy-1,4-naphthoquinones (2-OH-1,4-NQs) that target Hp ThyX. Our lead-like molecules markedly inhibited the NADPH oxidation and 2′-deoxythymidine-5′-monophosphate-forming activities

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Jacobson, Azita, Changdong Yan, Qun Gao, et al. "Aging enhances pressure-induced arterial superoxide formation." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 3 (2007): H1344—H1350. http://dx.doi.org/10.1152/ajpheart.00413.2007.

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The purpose of this study was to investigate the mechanisms that regulate superoxide (O2•−) production as a function of an acute elevation of intravascular pressure and age. Mesenteric arteries isolated from young (6 mo) and aged (24 mo) male Fischer 344 rats were used. O2•− production in vessels in response to 80 (normal pressure, NP) and 180 (high pressure, HP) mmHg was determined by the superoxide dismutase-inhibitable nitroblue tetrazolium (NBT) reduction assay. In vessels exposed to NP, O2•− production was significantly higher in aged than in young vessels (32.7 ± 7.0 vs. 15.4 ± 2.4 nmol·

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Bueno-Pereira, Thaina Omia, Priscila Rezeck Nunes, Mariana Bertozzi Matheus, Ananda Lini Vieira da Rocha та Valeria Cristina Sandrim. "Nebivolol Increases Nitric Oxide Synthase via β3 Adrenergic Receptor in Endothelial Cells Following Exposure to Plasma from Preeclamptic Patients". Cells 11, № 5 (2022): 883. http://dx.doi.org/10.3390/cells11050883.

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Background: Low bioavailability of nitric oxide (NO) is related to the pathophysiology of preeclampsia (PE). In the present study, we investigated the effect of nebivolol (NEB), a β3-receptor agonist with vasodilator properties, on the NO synthesis in endothelial cells incubated with plasma from preeclamptic patients. Methods and results: Human umbilical vein endothelial cells (HUVECs) were incubated with plasma from healthy pregnant (HP) and PE women; NO quantification was assessed by a fluorescence compound. We found that endothelial cells incubated with plasma from women with PE show lower

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Lamarque, D., J. Tankovic, C. Dutreuil, JC Delchier, and BJR Whittle. "Induction of nitric oxide synthase by an extract of Helicobacter pylori (Hp) in rat duodenum." Gastroenterology 108, no. 4 (1995): A143. http://dx.doi.org/10.1016/0016-5085(95)23234-6.

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23

Xudong, Gu, Zhang Fengju, Wang Teng, Xie Xiaowei, Jia Xiaohui, and Xu Xing. "Effects of nitrogen and phosphorus addition on growth and leaf nitrogen metabolism of alfalfa in alkaline soil in Yinchuan Plain of Hetao Basin." PeerJ 10 (April 13, 2022): e13261. http://dx.doi.org/10.7717/peerj.13261.

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Alkaline soil is widely distributed in China. Its rational utilization is an effective measure to solve land shortage and improve the environment. Alfalfa is characterized by strong salt and alkali tolerance and high yield and protein content. Nitrogen (N) and phosphorus (P) are the main nutrients for plant growth, and N metabolism is one of the primary forms of plant metabolism, which plays a vital role in quality and yield formation. The exploration of the effect of N and P on N metabolism and alfalfa growth will provide a theoretical basis for scientific fertilization for alfalfa in the alk

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Brenndörfer, Maria, Hans Albert Brune, Tony Debaerdemaeker, and Reinhard Hemmer. "Synthesen, Kristall- und Molekülstruktur ionischer Nickel-Komplexe mit Phosphanen im kationischen und anionischen Komplex-Teil / Syntheses, Crystal and Molecular Structure of Ionic Nickel Complexes with Phosphanes in the Cationic and Anionic Part." Zeitschrift für Naturforschung B 40, no. 3 (1985): 357–62. http://dx.doi.org/10.1515/znb-1985-0308.

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The syntheses of five new nickel-II-complexes of the type [HPR′3][R3PNiCl3] (R,R′ = C6H5, n-C4H9, C6H11 , C5H9 and R = C6H5, R′ = C6H11) are described.The structure of the compound [HP(C6H11)3][(C6H5)3PNiCl3] was determined by X-ray analysis. The crystals are monoclinic; space group P21/n with the lattice parameters a = 18.180(5), b = 18.842(4), c = 11.173(3) Å and β = 107.12(6)°; Z = 4.

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Adamia, Sophia, Amanda Reichert, Anirban Ghosh, et al. "Germline and Somatic Mutations in the Hyaluronan Synthase–1 (HAS1) Gene May Contribute to Oncogenesis in Multiple Myeloma (MM) and Waldenstrom’s Macroglobulinemia (WM)." Blood 110, no. 11 (2007): 2488. http://dx.doi.org/10.1182/blood.v110.11.2488.2488.

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Abstract In MM and WM, we identified aberrant HAS1 splice variants that were absent from normal donors (HD) and B-CLL. Here we sequenced multiple subclones from multiple cell subsets to show that aberrant HAS1 splicing results from cryptic splice sites activation. Aberrant splicing defects are the consequences of genetic variations (GVs) detected in the sequence of classical splicing elements as well as within exons and introns. To investigate HAS1 splicing in MM and WM patients, we sequenced the HAS1 gene segments involved in abnormal splicing events. HAS1 from buccal epithelial cells (BEC) r

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Kaihara, Julyane N. S., Caroline K. Minami, Maria T. S. Peraçoli, et al. "Plasma eNOS Concentration in Healthy Pregnancy and in Hypertensive Disorders of Pregnancy: Evidence of Reduced Concentrations in Pre-Eclampsia from Two Independent Studies." Diseases 11, no. 4 (2023): 155. http://dx.doi.org/10.3390/diseases11040155.

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Hypertensive disorders of pregnancy (HDP), comprising gestational hypertension (GH) and pre-eclampsia (PE), are leading causes of maternal and perinatal morbidity and mortality. Both GH and PE are characterized by new-onset hypertension, but PE additionally includes proteinuria and/or end-organ damage. Impaired nitric oxide (NO) bioavailability may lead to endothelial dysfunction in GH and PE, and the primary source of vascular NO is endothelial NO synthase (eNOS). However, no previous study has investigated plasma eNOS concentrations in patients with GH and PE. In this study, we compared plas

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Minami, N., Y. Imai, J. Hashimoto, and K. Abe. "The role of nitric oxide in the baroreceptor-cardiac reflex in conscious Wistar rats." American Journal of Physiology-Heart and Circulatory Physiology 269, no. 3 (1995): H851—H855. http://dx.doi.org/10.1152/ajpheart.1995.269.3.h851.

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The role of nitric oxide (NO) in baroreceptor-cardiac reflex function was examined using a NO synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME), in conscious Wistar rats. Mean arterial pressure (MAP) and heart period (HP) relationships were obtained by intravenous injection of graded doses of phenylephrine and sodium nitroprusside (SNP). The baroreflex function was compared before and after L-NAME (10 mg/kg iv), L-NAME (10 mg/kg iv) followed by exogenous NO supplied as SNP (10-20 micrograms.kg-1.min-1 iv), or SNP alone (20 micrograms.kg-1.min-1 iv). To find the effect of chang

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Ohnishi, Shiho, Ning Ma, Raynoo Thanan, et al. "DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/387014.

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Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells and result in oxidative and nitrative DNA damage, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has been implicated in the initiation and/or promotion of inflammation-mediated carcinogenesis. It has been estimated that various infectious agents are carcinogenic to humans (IARC group 1)

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Simon, Diána, Szabina Erdő-Bonyár, Katalin Böröcz, et al. "Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis." International Journal of Molecular Sciences 25, no. 3 (2024): 1423. http://dx.doi.org/10.3390/ijms25031423.

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The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pre

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Lindenberg, Frank, Evamarie Hey-Hawkins, and Gerhard Baum. "Aminolyse von Cp2ZrCl{P(SiMe3)2} - Synthese und Molekülstruktur von Cp2ZrCl(NHPh) / Aminolysis of Cp2ZrCl{P(SiMe3)2} - Synthesis and Molecular Structure of Cp2ZrCl(NHPh)." Zeitschrift für Naturforschung B 50, no. 9 (1995): 1359–61. http://dx.doi.org/10.1515/znb-1995-0911.

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AbstractThe reaction of Cp2ZrCl{P(SiMe3)2} with aniline yields the terminal zirconocene phenylamido complex Cp2ZrCl(NHPh) (1) and HP(SiMe3)2. 1 was characterized spectroscopically (n.m.r., i.r.) and by X-ray structure determination (monoclinic space group P2 {ln, a - 6.589(2), b = 19.978(3), c = 13.512(2) Å , β = 101.09(2)° (at 200 K)). The NHPh group is planar with Zr -N 2116(10) Å.

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Zhang, Jingying, Changhai Sui, Yanli Wang, et al. "Transcriptome-Wide Analysis Reveals Key DEGs in Flower Color Regulation of Hosta plantaginea (Lam.) Aschers." Genes 11, no. 1 (2019): 31. http://dx.doi.org/10.3390/genes11010031.

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Background: Hosta plantaginea (Lam.) Aschers (HPA), a species in the family Liliaceae, is an important landscaping plant and herbaceous ornamental flower. However, because the flower has only two colors, white and purple, color matching applications are extremely limited. To date, the mechanism underlying flower color regulation remains unclear. Methods: In this study, the transcriptomes of three cultivars—H. plantaginea (HP, white flower), H. Cathayana (HC, purple flower), and H. plantaginea ‘Summer Fragrance’ (HS, purple flower)—at three flowering stages (bud stage, initial stage, and late f

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Deng, Guoliang, Zhiqing Jiang, Hui Lu, et al. "A Study on the Amelioration of Circadian Rhythm Disorders in Fat Mice Using High-Protein Diets." Nutrients 15, no. 15 (2023): 3459. http://dx.doi.org/10.3390/nu15153459.

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This innovative study investigates the effects of high-protein diets (milk protein) on the circadian rhythm of hepatic lipid metabolism. We aimed to understand how high-protein interventions regulate biological clock genes, maintain lipid metabolism balance, and affect the circadian rhythm of antioxidant levels in vivo. We divided 120 SPF-class C57BL/6J mice into the control, high-fat/low-protein (HF-LP), and high-fat/high-protein (HF-HP) groups. Mice were sacrificed during active (2 a.m. and 8 a.m.) and rest periods (2 p.m. and 8 p.m.). In the HF-LP group, hepatic lipid anabolic enzymes were

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Abou-Mohamed, G., A. Papapetropoulos, D. Ulrich, J. D. Catravas, R. R. Tuttle, and R. W. Caldwell. "HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro." Journal of Pharmacology and Experimental Therapeutics 275, no. 2 (1995): 584–91. https://doi.org/10.1016/s0022-3565(25)12104-6.

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Nocheva, Hristina, Nikolay S. Krastev, Dimo S. Krastev, and Milka Mileva. "The Endogenous Cannabinoid and the Nitricoxidergic Systems in the Modulation of Stress Responses." International Journal of Molecular Sciences 24, no. 3 (2023): 2886. http://dx.doi.org/10.3390/ijms24032886.

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The effects on stress-induced analgesia (SIA) from endogenous cannabinoid system (ECS) and nitric oxide (NO) interaction after 1 h of restraint stress were evaluated in male Wistar rats. The animals were subjected to 1 h of restraint and then injected with different combinations of cannabinoid receptor type 1 agonist anandamide (AEA) or antagonist AM251 along with an NO donor, NO precursor, or inhibitor of NO synthase. Nociception was evaluated using paw pressure (PP) or hot plate (HP) tests. AEA was administered immediately after the end of restraint-SIA (r-SIA). Administration of NO precurso

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Masnoddin, Makdi, Clemente Michael Wong Vui Ling, and Nur Athirah Yusof. "Functional Analysis of Conserved Hypothetical Proteins from the Antarctic Bacterium, Pedobacter cryoconitis Strain BG5 Reveals Protein Cold Adaptation and Thermal Tolerance Strategies." Microorganisms 10, no. 8 (2022): 1654. http://dx.doi.org/10.3390/microorganisms10081654.

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Pedobacter cryoconitis BG5 is an obligate psychrophilic bacterium that was first isolated on King George Island, Antarctica. Over the last 50 years, the West Antarctic, including King George Island, has been one of the most rapidly warming places on Earth, hence making it an excellent area to measure the resilience of living species in warmed areas exposed to the constantly changing environment due to climate change. This bacterium encodes a genome of approximately 5694 protein-coding genes. However, 35% of the gene models for this species are found to be hypothetical proteins (HP). In this st

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Jeazet Dongho Epse Mackon, Guibeline Charlie, Enerand Mackon, Yafei Ma, et al. "Development of the PARMS Markers of the Waxy Gene and Utilization in Discriminating Wild Accessions, and Cultivated Rice (Oryza sativa L.) with Different Eating and Cooking Quality." Agronomy 12, no. 6 (2022): 1294. http://dx.doi.org/10.3390/agronomy12061294.

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Amylose content (AC) is the major indicator of rice eating and cooking quality (ECQ). Its synthesis in rice endosperm is mainly regulated by the protein, granule-bound starch synthase 1, which is encoded by the waxy gene (Os06g0133000, LOC_Os06g04200). The diversity of AC is largely attributable to the allelic variation at the Wx locus and the development of effective and accurate functional molecular markers to target rice variant alleles is crucial in the breeding strategy. In the present study, we developed six pairs of penta-primer amplification refractory mutation system (PARMS) markers t

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Grobe, Joseph, Duc Le Van, Bettina Lüth та Marianne Hegemann. "Reaktive EC(p-p)π-Systeme, XXVI. Einfache Synthese für Methylenphosphane (Phosphaalkene) des Typs HPC(F)NR2 und das Phosphaalkin PC-N(iPr)2". Chemische Berichte 123, № 12 (1990): 2317–20. http://dx.doi.org/10.1002/cber.19901231213.

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Cho, Sujin, Hookang Im, Ki-Young Lee, et al. "Identification of novel scaffolds for potential anti- Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy- d -manno-octulosonate 8-phosphate synthase ( Hp KDO8PS)." European Journal of Medicinal Chemistry 108 (January 2016): 188–202. http://dx.doi.org/10.1016/j.ejmech.2015.11.036.

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Abdelmohsen, Shaimaa R., Ranya M. Abdelgalil, Asmaa M. Elmaghraby, et al. "Platelet-Rich Plasma (PRP) Mitigates Silver Nanoparticle (AgNP)-Induced Pulmonary Fibrosis via iNOS/CD68/CASP3/TWIST1 Regulation: An Experimental Study and Bioinformatics Analysis." International Journal of Molecular Sciences 26, no. 14 (2025): 6782. https://doi.org/10.3390/ijms26146782.

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Platelet-rich plasma (PRP) has become an increasingly valuable biologic approach for personalized regenerative medicine because of its potent anti-inflammatory/healing effects. It is thought to be an excellent source of growth factors that can promote tissue healing and lessen fibrosis. Although this treatment has demonstrated effectiveness in numerous disease areas, its impact on pulmonary fibrosis (PF) caused by silver nanoparticles (AgNPs) via its antiapoptotic effects remains to be explored. AgNPs were synthesized biologically by Bacillus megaterium ATCC 55000. AgNP characterization was ca

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Goncharova, Valentina, Shinji Iizuka, Yu Yamaguchi, and Sophia Khaldoyanidi. "Hyaluronan Associated with the Bone Marrow Hematopoietic Microenvironment Is Required for the Recruitment and Retention of Hematopoietic Stem and Progenitor Cells In the Bone Marrow." Blood 116, no. 21 (2010): 2593. http://dx.doi.org/10.1182/blood.v116.21.2593.2593.

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Abstract Abstract 2593 The bone marrow microenvironment regulates a variety of hematopoietic stem cell (HSC) functions, including their recruitment into the marrow following transplantation. However, an insufficient understanding of the biology of the hematopoietic microenvironment reflects gaps in our knowledge of fundamental stem cell biology and remains an obstacle to an optimal therapeutic approach. While the involvement of hyaluronan (HA), one of the major components of the bone marrow ECM, in normal cell and tumor biology is generally appreciated, little is known of how HA contributes to

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Arnold, Adson Hagen, and Kathrin Castiglione. "Comparative Evaluation of the Asymmetric Synthesis of (S)-Norlaudanosoline in a Two-Step Biocatalytic Reaction with Whole Escherichia coli Cells in Batch and Continuous Flow Catalysis." Catalysts 13, no. 10 (2023): 1347. http://dx.doi.org/10.3390/catal13101347.

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Opioids are important analgesics, and their pharmaceutical application is increasing worldwide. Many opioids are based on benzylisoquinoline alkaloids (BIA) and are still industrially produced from Papaver somniferum (opium poppy). (S)-norlaudanosoline ((S)-NLS) is a complex BIA and an advanced intermediate for diverse pharmaceuticals. The efficient synthesis of this scaffold could pave the way for a plant-independent synthesis platform. Although a promising biocatalytic route to (S)-NLS using norcoclaurine synthase (NCS) and ω-transaminase (TAm) has already been explored, the cost-effectivene

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Wolfsberger, Werner, Wolfgang Burkart, Sonja Bauer, Andreas Hampp, Justin Wolf, and Helmut Werner. "Die Darstellung sterisch anspruchsvoller Phosphinoester und ihre Verwendung zur Synthese von Rhodium(I)-und Rhodium(III)-Komplexen [1] / The Preparation of Sterically Demanding Phosphinoesters and their Use for the Synthesis of Rhodium(I) and Rhodium (III) Complexes." Zeitschrift für Naturforschung B 49, no. 12 (1994): 1659–73. http://dx.doi.org/10.1515/znb-1994-1209.

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Two routes for the preparation of sterically demanding phosphinoesters RR′P(CH2)nCO2Me (n=1,2 or 3) and RR′P(CH2)nCO2Et (n=1 or 2) have been developed: (1) reaction of trimethyl-silyl phosphines RR′PSiMe3 (R=R′=/Pr. rBu) with ω-chloroalkylesters, and (2) hydrophos- phination of secondary phosphines HP(R)Ph (R = Me, Et. Pr. iPr, iBu) with unsaturated carboxylic esters. From iPr2PCH2CO2Me (3) and iPr2PCH2CO2Et (4), a variety of rhodium(I) and rhodium(III) complexes, mainly with alkyne and vinylidene ligands, have been prepared. Compound [RhCl(C8H14)2]2 (19) reacts with four equiv. of 3 to give [

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Wang, Si-Yi, Yan Liu, Xiao-Mao Li, et al. "Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Datura metel Seeds." Molecules 26, no. 19 (2021): 5946. http://dx.doi.org/10.3390/molecules26195946.

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As a new target protein for Alzheimer’s disease (AD), the triggering receptor expressed on myeloid Cells 2 (TREM2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring AD. In this study, a novel recognition system based on surface plasmon resonance (SPR) for the TREM2 target spot was established coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-MS), in order to screen the active ingredients targeting TREM2 from Datura metel seeds. The re

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Rogers, Stephen C., Zohreh Safari, Mary E. Brummet, et al. "RBC eNOS Regulates O2 Delivery Phenotype during Circulatory Transit Via Control of Intracellular pH." Blood 144, Supplement 1 (2024): 1074. https://doi.org/10.1182/blood-2024-210690.

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BACKGROUND: As red blood cells (RBCs) traverse circulatory O2 gradients, RBC endothelial nitric oxide synthase (eNOS) migrates on and off the membrane, undergoing oscillatory activation/inactivation. Upon deoxygenation RBC eNOS is activated in a process dependent on hemoglobin (Hb) conformation, stimulation of the mechanosensitive Piezo1 channel, calcium influx and calmodulin association. Previously, we have demonstrated eNOS dependent regulation of RBC energetics, following glycolytic metabolon disassembly and key enzyme inactivation, resulting from protein s-nitrosylation. We have additional

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Peng, Xinlv, Caixia Pei, Eika W. Qian, Yuguang Du, and Jian-Jun Li. "Co-immobilization of a bi-enzymatic cascade into hierarchically porous MIL-53 for efficient 6′-sialyllactose production." Nanoscale, 2024. http://dx.doi.org/10.1039/d4nr01775g.

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CMP–sialic acid synthase and α-2,6-sialyltransferase were co-immobilized into HP-MIL-53. The co-immobilized enzymes exhibited high initial catalytic efficiency, reusability and thermal, pH and storage stability.

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Kim, Tae Eun, and Jaeho Pyee. "Impact of High‐Pressure Processing on Phenolic Compound Accumulation and Expression of Key Biosynthetic Genes in Harvested Strawberries." Molecular Nutrition & Food Research, March 3, 2025. https://doi.org/10.1002/mnfr.202400882.

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ABSTRACTPhytochemical accumulation plays a vital role in plant defense. This study examines the effect of high‐pressure (HP) treatment on phenolic biosynthesis and gene expression in harvested strawberries, evaluating HP as a potential enhancer of phenolic biosynthesis through environmental stress responses. Strawberries were subjected to HP treatment at pressures ranging from 10 to 40 MPa in two or three cycles. This treatment led to significant increases in total phenolic content, up to 1.59 times higher than untreated controls. Gene expression analysis showed upregulation of key biosyntheti

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Chang, Zhishuai, Wei Dai, Yufeng Mao, et al. "Enhanced 3-Hydroxypropionic Acid Production From Acetate via the Malonyl-CoA Pathway in Corynebacterium glutamicum." Frontiers in Bioengineering and Biotechnology 9 (January 13, 2022). http://dx.doi.org/10.3389/fbioe.2021.808258.

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Acetate is an economical and environmental-friendly alternative carbon source. Herein, the potential of harnessing Corynebacterium glutamicum as a host to produce 3-hydroxypropionic acid (3-HP) from acetate was explored. First, the expression level of malonyl-CoA reductase from Chloroflexus aurantiacus was optimized through several strategies, strain Cgz2/sod-N-C* showed an MCR enzyme activity of 63 nmol/mg/min and a 3-HP titer of 0.66 g/L in flasks. Next, the expression of citrate synthase in Cgz2/sod-N-C* was weakened to reduce the acetyl-CoA consumption in the TCA cycle, and the resulting s

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Liang, Yan-Fei, Le-Tian Yan, Qiao Yue та ін. "Preparation of a whole cell catalyst overexpressing acetohydroxyacid synthase of Thermotoga maritima and its application in the syntheses of α-hydroxyketones". Scientific Reports 10, № 1 (2020). http://dx.doi.org/10.1038/s41598-020-72416-6.

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Abstract The large catalytic subunit of acetohydroxyacid synthase (AHAS, EC 2.2.1.6) of Thermotoga maritima (TmcAHAS) was prepared in this study. It possesses high specific activity and excellent stability. The protein and a whole cell catalyst overexpressing the protein were applied to the preparation of α-hydroxyketones including acetoin (AC), 3-hydroxy-2-pentanone (HP), and (R)-phenylacetylcarbinol (R-PAC). The results show that AC and HP could be produced in high yields (84% and 62%, respectively), while R-PAC could be synthesized in a high yield (about 78%) with an R/S ratio of 9:1. There

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Xu, Shijie, Weibo Qiao, Zuanwen Wang, Xiaoying Fu, Zihe Liu, and Shuobo Shi. "Exploiting a heterologous construction of the 3-hydroxypropionic acid carbon fixation pathway with mesaconate as an indicator in Saccharomyces cerevisiae." Bioresources and Bioprocessing 10, no. 1 (2023). http://dx.doi.org/10.1186/s40643-023-00652-5.

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AbstractThe 3-Hydroxypropionic acid (3-HP) pathway is one of the six known natural carbon fixation pathways, in which the carbon species used is bicarbonate. It has been considered to be the most suitable pathway for aerobic CO2 fixation among the six natural carbon fixation pathways. Mesaconate is a high value-added derivative in the 3-HP pathway and can be used as a co-monomer to produce fire-retardant materials and hydrogels. In this study, we use mesaconate as a reporting compound to evaluate the construction and optimization of the sub-part of the 3-HP pathway in Saccharomyces cerevisiae.

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Mohammed, Nourhan, Sahar A. Ahmed, Nagah I. Hegazy, and Kamal Kashishy. "Ameliorative effects of hesperidin and N-acetylcysteine against formaldehyde-induced-hemato- and genotoxicity." Toxicology Research, August 24, 2021. http://dx.doi.org/10.1093/toxres/tfab083.

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Abstract This study investigated the hemato- and genotoxic effects of formaldehyde (FA) and the possible mitigating role of hesperidin (HP) and N-acetylcysteine (NAC), each alone and in combination. Sixty-four adult male albino rats were divided into eight equal groups; the study was conducted for 8 weeks; Group I (negative control: received no medication), Group II (positive control: received distilled water), Group III (received HP 50 mg/kg/day), Group IV (received NAC 50 mg/kg/day), Group V (received FA 10 mg/kg/day), Group VI (FA + HP), Group VII (FA + NAC), and Group VIII (FA + HP + NAC).

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