Relevant bibliographies by topics / Synthese interactive

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Academic literature on the topic 'Synthese interactive'

Author: Grafiati
Published: 24 August 2023

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Journal articles on the topic "Synthese interactive"

1

Weber, Ute, Laszlo Zsolnai, and Gottfried Hüttner. "Synthesen und Strukturen von Distibankomplexen / Syntheses and Structures of Distibane Complexes." Zeitschrift für Naturforschung B 40, no. 11 (1985): 1430–36. http://dx.doi.org/10.1515/znb-1985-1103.

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Stibanes RSbHal2 are reductivly coupled by interaction with Na2M2(CO)10 (M = Cr, W) or Cp(CO)2MnTHF. The resulting distibanes RS̲b̲(Hal)-(Hal)S̲b̲R are coordinated to sixteen elec­tron LnM-fragments (LnM=M(CO)5, Cp(CO)2Mn). Both the meso and d/l stereoisomeres are structurally characterised by X-ray analyses.
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Spikes, Tobias E., Martin G. Montgomery, and John E. Walker. "Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes." Proceedings of the National Academy of Sciences 118, no. 8 (2021): e2021012118. http://dx.doi.org/10.1073/pnas.2021012118.

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The ATP synthase complexes in mitochondria make the ATP required to sustain life by a rotary mechanism. Their membrane domains are embedded in the inner membranes of the organelle, and they dimerize via interactions between their membrane domains. The dimers form extensive chains along the tips of the cristae with the two rows of monomeric catalytic domains extending into the mitochondrial matrix at an angle to each other. Disruption of the interface between dimers by mutation affects the morphology of the cristae severely. By analysis of particles of purified dimeric bovine ATP synthase by cryo-electron microscopy, we have shown that the angle between the central rotatory axes of the monomeric complexes varies between ca. 76 and 95°. These particles represent active dimeric ATP synthase. Some angular variations arise directly from the catalytic mechanism of the enzyme, and others are independent of catalysis. The monomer–monomer interaction is mediated mainly by j subunits attached to the surface of wedge-shaped protein-lipid structures in the membrane domain of the complex, and the angular variation arises from rotational and translational changes in this interaction, and combinations of both. The structures also suggest how the dimeric ATP synthases might be interacting with each other to form the characteristic rows along the tips of the cristae via other interwedge contacts, molding themselves to the range of oligomeric arrangements observed by tomography of mitochondrial membranes, and at the same time allowing the ATP synthase to operate under the range of physiological conditions that influence the structure of the cristae.
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Li, Chunhong, Sreelatha Sarangapani, Qian Wang, Kumar Nadimuthu, and Rajani Sarojam. "Metabolic Engineering of the Native Monoterpene Pathway in Spearmint for Production of Heterologous Monoterpenes Reveals Complex Metabolism and Pathway Interactions." International Journal of Molecular Sciences 21, no. 17 (2020): 6164. http://dx.doi.org/10.3390/ijms21176164.

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Spearmint produces and stores large amounts of monoterpenes, mainly limonene and carvone, in glandular trichomes and is the major natural source of these compounds. Towards producing heterologous monoterpenes in spearmint, we first reduced the flux into the native limonene pathway by knocking down the expression of limonene synthase (MsLS) by RNAi method. The MsLS RNAi lines exhibited a huge reduction in the synthesis of limonene and carvone. Detailed GC-MS and LC-MS analysis revealed that MsLS RNAi plants also showed an increase in sesquiterpene, phytosterols, fatty acids, flavonoids, and phenolic metabolites, suggesting an interaction between the MEP, MVA shikimate and fatty acid pathways in spearmint. Three different heterologous monoterpene synthases namely, linalool synthase and myrcene synthase from Picea abies and geraniol synthase from Cananga odorata were cloned and introduced independently into the MsLS RNAi mutant background. The expression of these heterologous terpene synthases resulted mainly in production of monoterpene derivatives. Of all the introduced monoterpenes geraniol showed the maximum number of derivatives. Our results provide new insights into MEP pathway interactions and regulation and reveals the existence of mechanisms for complex metabolism of monoterpenes in spearmint.
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Moolhuijzen, Paula M., Mariano Jordi Muria-Gonzalez, Robert Syme, et al. "Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp." Toxins 12, no. 4 (2020): 242. http://dx.doi.org/10.3390/toxins12040242.

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Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM) within Pyrenophora pathogenic species remains mostly uncharted. In this study, an in-depth comparative analysis of the P. teres f. teres, P teres f. maculata and P. tritici-repentis potential to produce SMs, based on in silico predicted biosynthetic gene clusters (BGCs), was conducted using genome assemblies from PacBio DNA reads. Conservation of BGCs between the Pyrenophora species included type I polyketide synthases, terpene synthases and the first reporting of a type III polyketide synthase in P teres f. maculata. P. teres isolates exhibited substantial expansion of non-ribosomal peptide synthases relative to P. tritici-repentis, hallmarked by the presence of tailoring cis-acting nitrogen methyltransferase domains. P. teres isolates also possessed unique non-ribosomal peptide synthase (NRPS)-indole and indole BGCs, while a P. tritici-repentis phytotoxin BGC for triticone production was absent in P. teres. These differences highlight diversification between the pathogens that reflects their different evolutionary histories, host adaption and lifestyles.
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Webby, Celia J., Mark L. Patchett, and Emily J. Parker. "Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori." Biochemical Journal 390, no. 1 (2005): 223–30. http://dx.doi.org/10.1042/bj20050259.

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DAH7P (3-Deoxy-D-arabino-heptulosonate 7-phosphate) synthase catalyses the condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) as the first committed step in the biosynthesis of aromatic compounds in plants and micro-organisms. Previous work has identified two families of DAH7P synthases based on sequence similarity and molecular mass, with the majority of the mechanistic and structural studies being carried out on the type I paralogues from Escherichia coli. Whereas a number of organisms possess genes encoding both type I and type II DAH7P synthases, the pathogen Helicobacter pylori has only a single, type II, enzyme. Recombinant DAH7P synthase from H. pylori was partially solubilized by co-expression with chaperonins GroEL/GroES in E. coli, and purified to homogeneity. The enzyme reaction follows an ordered sequential mechanism with the following kinetic parameters: Km (PEP), 3 μM; Km (E4P), 6 μM; and kcat, 3.3 s−1. The enzyme reaction involves interaction of the si face of PEP with the re face of E4P. H. pylori DAH7P synthase is not inhibited by phenylalanine, tyrosine, tryptophan or chorismate. EDTA inactivates the enzyme, and activity is restored by a range of bivalent metal ions, including (in order of decreasing effectiveness) Co2+, Mn2+, Ca2+, Mg2+, Cu2+ and Zn2+. Analysis of type II DAH7P synthase sequences reveals several highly conserved motifs, and comparison with the type I enzymes suggests that catalysis by these two enzyme types occurs on a similar active-site scaffold and that the two DAH7P synthase families may indeed be distantly related.
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Biuković, Goran, Sandip Basak, Malathy Sony Subramanian Manimekalai та ін. "Variations of Subunit ε of the Mycobacterium tuberculosis F1FoATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207". Antimicrobial Agents and Chemotherapy 57, № 1 (2012): 168–76. http://dx.doi.org/10.1128/aac.01039-12.

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ABSTRACTThe subunit ε of bacterial F1FOATP synthases plays an important regulatory role in coupling and catalysis via conformational transitions of its C-terminal domain. Here we present the first low-resolution solution structure of ε ofMycobacterium tuberculosis(Mtε) F1FOATP synthase and the nuclear magnetic resonance (NMR) structure of its C-terminal segment (Mtε103–120).Mtε is significantly shorter (61.6 Å) than forms of the subunit in other bacteria, reflecting a shorter C-terminal sequence, proposed to be important in coupling processes via the catalytic β subunit. The C-terminal segment displays an α-helical structure and a highly positive surface charge due to the presence of arginine residues. Using NMR spectroscopy, fluorescence spectroscopy, and mutagenesis, we demonstrate that the new tuberculosis (TB) drug candidate TMC207, proposed to bind to the proton translocatingc-ring, also binds toMtε. A model for the interaction of TMC207 with both ε and thec-ring is presented, suggesting that TMC207 forms a wedge between the two rotating subunits by interacting with the residues W15 and F50 of ε and thec-ring, respectively. T19 and R37 of ε provide the necessary polar interactions with the drug molecule. This new model of the mechanism of TMC207 provides the basis for the design of new drugs targeting the F1FOATP synthase inM. tuberculosis.
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Mühleip, Alexander W., Friederike Joos, Christoph Wigge, Achilleas S. Frangakis, Werner Kühlbrandt, and Karen M. Davies. "Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria." Proceedings of the National Academy of Sciences 113, no. 30 (2016): 8442–47. http://dx.doi.org/10.1073/pnas.1525430113.

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F1Fo-ATP synthases are universal energy-converting membrane protein complexes that synthesize ATP from ADP and inorganic phosphate. In mitochondria of yeast and mammals, the ATP synthase forms V-shaped dimers, which assemble into rows along the highly curved ridges of lamellar cristae. Using electron cryotomography and subtomogram averaging, we have determined the in situ structure and organization of the mitochondrial ATP synthase dimer of the ciliate Paramecium tetraurelia. The ATP synthase forms U-shaped dimers with parallel monomers. Each complex has a prominent intracrista domain, which links the c-ring of one monomer to the peripheral stalk of the other. Close interaction of intracrista domains in adjacent dimers results in the formation of helical ATP synthase dimer arrays, which differ from the loose dimer rows in all other organisms observed so far. The parameters of the helical arrays match those of the cristae tubes, suggesting the unique features of the P. tetraurelia ATP synthase are directly responsible for generating the helical tubular cristae. We conclude that despite major structural differences between ATP synthase dimers of ciliates and other eukaryotes, the formation of ATP synthase dimer rows is a universal feature of mitochondria and a fundamental determinant of cristae morphology.
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Gu, Ying, and Chris Somerville. "Cellulose synthase interacting protein." Plant Signaling & Behavior 5, no. 12 (2010): 1571–74. http://dx.doi.org/10.4161/psb.5.12.13621.

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Sotodosos-Alonso, Laura, María García-García, Enrique Calvo, et al. "Cell tension controlling pathways and nutrient availability regulate plasma membrane ATP synthase trafficking." IBJ Plus 1, s5 (2022): 45. http://dx.doi.org/10.24217/2531-0151.22v1s5.00045.

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Introduction: The interplay between mechanical stress and cell metabolism is an emerging topic. However, the mechanotransduction pathways coordinating cell metabolism to the tensional status of the cell are poorly understood. Here, we provide several evidences suggesting that caveolae – mechanosensitive plasma membrane invaginations-, nutrient availability and cell tension controlling conditions are important for the biology of mitochondrial ATP synthase. Material and Methods: For achieving the caveolar interactome, plasma membrane biotinylation and co-localization experiments, we have used human retinal pigment epithelial-1 (RPE-1) cells, murine vascular aortic smooth muscle (MOVAS) cells and mouse embryonic fibroblasts (MEF). We used proximity-dependent biotin identification (BioID) and mass spectrometry to obtain the different interactomes of caveolar components. For plasma membrane (PM) localization of the ATP synthase we used PM biotinylation under different metabolic and mechanical conditions (nutrient starving, cell confluence). To study co-localization, we performed Proximity Ligation Assays (PLAs) in combination with mitochondrial and caveolar markers. Results: First, we have identified the interactome of all core caveolar components. Among the interactors, we identified subunits α and β of the mitochondrial ATP synthase, which interact with most of the caveolar components. Apart from its main localization at the inner mitochondrial membrane, the ATP synthase has also been detected in the PM, facing the extracellular space; this pool is known as ecto-ATP synthase. We show that the interaction with Caveolin-1 (Cav1), one of the main components of caveolae, occurs outside caveolae and mitochondria. In addition, the presence of ecto- ATP synthase at the PM is dependent on Cav1. Furthermore, conditions regulating cell tension, and metabolic challenges that promote autophagy, impinge on ecto-ATP synthase trafficking Conclusions: This study has characterized the interactome of caveolar components and has focused on the subunits α and β of the ATP synthase, which are also present at the PM. These subunits interact with Cav-1, but this interaction seems to occur in intracellular trafficking vesicles. Moreover, this process could be altered by mechanical cues and nutrient deprivation. Thus, our study suggests that trafficking routes regulating PM residents, and regulated by several caveolar components, are linked to nutrient starvation and mitochondrial biology.
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Rode, W., and A. Leś. "Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP." Acta Biochimica Polonica 43, no. 1 (1996): 133–42. http://dx.doi.org/10.18388/abp.1996_4524.

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Thymidylate synthase is a target enzyme in anticancer, antiviral, antifungal and antiprotozoan chemotherapy. With two dUMP analogues, 5-fluoro-dUMP (FdUMP) and 5-(trifluoromethyl)-dUMP (CF3dUMP), strong thymidylate synthase inhibitors and active forms of drugs, the inhibition mechanism is based on the reaction mechanism. Recent comparative studies of new dUMP analogues, containing more than one substituent in the pyrimidine ring, showed that substitution of the pyrimidine ring C(4) = O group in FdUMP by either C(4) = N-OH group (in N4-hydroxy-FdCMP) or C(4) = S group (in 4-thio-FdUMP) preserves high inhibitory potency of the drug but may alter its specificity for thymidylate synthases from various sources, which differ in sensitivity to slow-binding inhibition by FdUMP. Informations suggesting mechanisms responsible for the foregoing have been reviewed, including results of molecular modeling studies suggesting interaction of the pyrimidine C(4) = O group, or its modification, with the N5,10-methylene.(ABSTRACT TRUNCATED)
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Dissertations / Theses on the topic "Synthese interactive"

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Ding, Hong. "Synthèse architecturale interactive et flexible." Phd thesis, Grenoble INPG, 1996. http://www.theses.fr/1996INPG0053.

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Cette thèse présente plusieurs travaux visant à l'amélioration de la synthèse architecturale réalisée à l'aide de l'outil de synthèse de haut niveau AMICAL. Un point clé de ce travail est la notion d'interactivité. Le processus de synthèse se décompose en un ensemble de raffinements successifs. L'utilisateur a la possibilité d'intervenir au cours de ces différentes étapes et d'agir manuellement, ou au contraire de laisser se dérouler seules l'ensemble des étapes tout en gardant une vision claire des actions effectuées. Ce dernier a de plus le choix entre plusieurs styles architecturaux qu'il pourra implémenter à son gré, ce qui autorise une grande flexibilité. Les points principaux abordés au cours de cette thèse sont les suivants: Les étapes et modèles successifs de raffinement au cours du processus de synthèse: chaque sous-tâche engendre un modèle architectural intermédiaire à partir duquel la sous-tâche suivante pourra agir. La notion d'interactivité: celle-ci inclue la mise au point d'un modèle de performance permettant d'estimer la qualité du circuit synthètisé, et permet au concepteur d'être le véritable acteur de la synthèse tout en l'assistant lors de la prise de décisions. La génération de plusieurs types d'architectures et les problèmes algorithmiques qui y sont liés<br>This thesis presents an interactive High Level Synthesis environment called AMICAL. The synthesis process is decomposed into a set of refinement steps. The user can execute these steps automatically, manually or in interactive mode when needed. The synthesis scheme is flexible; it allows several architectural models for the generated data-path ( bus model, multiplexer model) and controller (hardwired, programmable). The main issues developed in this thesis are: The models and steps used for refinements in a synthesis process. Several architectural models are defined for bridging gap between two synthesis steps. The interactive synthesis model. It includes a performance model allowing to estimate the synthesized results, and allows the designer to be a real actor of the synthesis process. The generation of different architectures and their algorithm issues. These architectures are usable as inputs for lower synthesis tools
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Heinrich, Stefan, and Maik Berger. "New concept of continuously interactive analysis-synthesis-parameter-adjustments (ASPA) for nonlinear drive assemblies." Technische Universität Chemnitz, 2015. https://monarch.qucosa.de/id/qucosa%3A23320.

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Dieser Beitrag zeigt, dass sich neue Möglichkeiten und Entwicklungsfelder beim Einsatz der domänenübergreifenden Simulationsumgebung SimulationX in der Getriebesynthese ergeben. Der Ansatz, jegliche nichtlineare Bewegungsaufgaben mathematisch in Form von Unterstützungsmodulen in einer Programmoberfläche zu komplexen Modellen zu verbinden, ermöglicht nun auch die Umsetzung einer ganzheitlichen Getriebesynthese mit einem kontinuierlichen Analyse-Synthese-Parameter-Abgleich (ASPA). Der Anwender kann somit in nur einer Programmoberfläche sowohl Mechanismen-Synthese als auch -Analyse durchführen und beispielsweise durch entsprechende Optimierung den getriebedynamisch günstigsten Mechanismus ermitteln.<br>This report shows that new opportunities and areas of development arise from using the domain spanning system simulation software SimulationX for the analysis and synthesis of nonlinear mechanisms. The idea to mathematically combine arbitrary motion demands to complex models in the form of support modules within a unique program interface now allows for a holistic mechanism synthesis with a continuous analysis-synthesis-parameter-adjustment (ASPA). Hence, the user may perform both mechanism analysis and synthesis employing one single program interface (e.g. to identify the ideal mechanism in terms of dynamics during an optimization process).
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SALSALI, MEHDI. "Art et distance psychique a l'ere de la realite virtuelle recherche theorique et realisation interactive en images de synthese 3d." Paris 8, 1999. http://www.theses.fr/1999PA081611.

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Cette these est constituee de trois parties qui concernent essentiellement la notion de la fin de l'histoire philosophique de l'art, l'usage de l'intelligence artifi♭ cielle dans l'art et la realite virtuelle artistique. Son objectif principal est d'etudier le concept de la distance psychique entre l'oeuvre d'art et le spectateur. Elle valorise l'idee selon laquelle cette distance s'est reduite au fur et a mesure des progres philo♭ sophiques et techniques, jusqu'a etre totalement rompue par la realite virtuelle. L'etude philosophique s'oriente d'une part aux idees des theoriciens de l'art classique notamment celles de hegel et de kant. D'autre part les fondements de l'ideologie de l'art moderne ont ete examines de pres par une analyse des conceptions d'arthur danto. Il a ete demontre qu'avec l'apparition de la photographie, les artistes commencerent de s'eloigner du principe de la representation realiste. D'abord ils tra♭ vaillerent l'aspect physique de la matiere picturale et leur propre expressivite. Puis ils s'interesserent a la conceptualite et se concentrerent sur la notion d'<< idee >>. Les expressionnistes abstraits se placerent sur la lignee de kant pour qui le ressenti du |<< beau >> passait d'abord par les sens et non par l'interpretation. Cependant le chemi♭ nement des artistes conceptuels se basa surtout sur les ideologies de l'art d'hegel qui ne valorisait l'art que par rapport a une definition. La discussion s'etend sur les progres technologiques dans les domaines artistiques qui en liberant l'artiste des problemes lies a l'execution pratique de l'oeuvre, soulignent l'importance du concepteur humain et valorisent les conceptions hege♭ liennes de l'art. A l'opposee, on s'apercoit que l'univers de la realite virtuelle consti♭ tue un outil d'acces a l'intuition sensible et penche la balance critique du cote des theories de l'art de kant. Le debat reste ouvert. Finalement, l'auteur commente l'une de ses realisations pratiques, presentee sous forme de cd rom avec cette these.
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Bozianu, Rodica. "Synthesis of Interactive Reactive Systems." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1026/document.

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Nous étudions le problème de la synthèse automatique de programmes dans des architectures multi-composants tels qu'elles respectent les spécifications par construction. Le principal objectif de cette thèse est de développer des procédures pour résoudre le problème de synthèse qui peut conduire à des implémentations efficaces. Chaque composant a une observation partielle sur l'état global du système multi-composants. Le problème est alors de fournir des protocoles basés sur les observations tel que les composants synthétisés assurent les spécifications pour tout le comportement de leur environnement. L'environnement peut être antagoniste, ou peut avoir ses propres objectifs et se comporter de façon rationnelle. Nous étudions d'abord le problème de synthèse lorsque l'environnement est présumé antagoniste. Pour ce contexte, nous proposons une procédure "Safraless" pour la synthèse d'un composant partiellement informé et un environnement omniscient à partir de spécications KLTL+. Elle est implémentée dans l'outil Acacia-K. Ensuite, nous étudions le problème de synthèse lorsque les composants de l'environnement ont leurs propres objectifs et sont rationnels. Pour le cadre plus simple de l'information parfaite, nous fournissons des complexités serrées pour des objectifs omega-réguliers particuliers. Pour le cas de l'information imparfaite, nous prouvons que le problème de la synthèse rationnelle est indécidable en général, mais nous regagnons la décidabilité si on demande à synthétiser un composant avec observation partielle contre un environnement multi-composante, omniscient et rationnel<br>We study the problem of automatic synthesis of programs in multi-component architectures such that they satisfy the specifications by construction. The main goal of the thesis is to develop procedures to solve the synthesis problem that may lead to efficient implementations.Each component may have partial observation on the global state of the multi-component system.Therefore, the synthesis problem asks to provide observation-based protocols for the components that have to be synthesized that ensure that specifications hold on all interactions with their environment.The environment may be antagonist, or may have its own objectives and behave rationally.We first study the synthesis problem when the environment is presumed to be completely antagonist. For this setting, we propose a "Safraless" procedure for the synthesis of one partially informed component and an omniscient environment from KLTL+ specifications. It is implemented in the tool Acacia-K. Secondly, we study the synthesis problem when the components in the environment have their own objectives and are rational. For the more relaxed setting of perfect information, we provide tight complexities for particular omega-regular objectives. Then, for the case of imperfect information, we prove that the rational synthesis problem is undecidable in general, but we gain decidability if is asked to synthesize only one component against a rational omniscient environment
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Ding, Hong. "Synthèse architecturale interactive et flexible." Phd thesis, Grenoble INPG, 1996. http://tel.archives-ouvertes.fr/tel-00010765.

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Cette thèse présente plusieurs travaux visant à l'amélioration de la synthèse architecturale réalisée à l'aide de l'outil de synthèse de haut niveau AMICAL. Un point clé de ce travail est la notion d'interactivité. Le processus de synthèse se décompose en un ensemble de raffinements successifs. L'utilisateur a la possibilité d'intervenir au cours de ces différentes étapes et d'agir manuellement, ou au contraire de laisser se dérouler seules l'ensemble des étapes tout en gardant une vision claire des actions effectuées. Ce dernier a de plus le choix entre plusieurs styles architecturaux qu'il pourra implémenter à son gré, ce qui autorise une grande flexibilité. Les points principaux abordés au cours de cette thèse sont les suivants: Les étapes et modèles successifs de raffinement au cours du processus de synthèse: chaque sous-tâche engendre un modèle architectural intermédiaire à partir duquel la sous-tâche suivante pourra agir. La notion d'interactivité: celle-ci inclue la mise au point d'un modèle de performance permettant d'estimer la qualité du circuit synthètisé, et permet au concepteur d'être le véritable acteur de la synthèse tout en l'assistant lors de la prise de décisions. La génération de plusieurs types d'architectures et les problèmes algorithmiques qui y sont liés.
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Le, Guillou-Clemencin Claire. "Effets secondaires des fluoroquinolones : synthèse de deux nouvelles fluoroquinolones." Paris 5, 1994. http://www.theses.fr/1994PA05P256.

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Lelong, Amélie. "Convergence phonétique en interaction Phonetic convergence in interaction." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENT079/document.

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Le travail présenté dans cette thèse est basé sur l’étude d’un phénomène appelé convergence phonétique qui postule que deux interlocuteurs en interaction vont avoir tendance à adapter leur façon de parler à leur interlocuteur dans un but communicatif. Nous avons donc mis en place un paradigme appelé « Dominos verbaux » afin de collecter un corpus large pour caractériser ce phénomène, le but final étant de doter un agent conversationnel animé de cette capacité d’adaptation afin d’améliorer la qualité des interactions homme-machine.Nous avons mené différentes études pour étudier le phénomène entre des paires d’inconnus, d’amis de longue date, puis entre des personnes provenant de la même famille. On s’attend à ce que l’amplitude de la convergence soit liée à la distance sociale entre les deux interlocuteurs. On retrouve bien ce résultat. Nous avons ensuite étudié l’impact de la connaissance de la cible linguistique sur l’adaptation. Pour caractériser la convergence phonétique, nous avons développé deux méthodes : la première basée sur une analyse discriminante linéaire entre les coefficients MFCC de chaque locuteur, la seconde utilisant la reconnaissance de parole. La dernière méthode nous permettra par la suite d’étudier le phénomène en condition moins contrôlée.Finalement, nous avons caractérisé la convergence phonétique à l’aide d’une mesure subjective en utilisant un nouveau test de perception basé sur la détection « en ligne » d’un changement de locuteur. Le test a été réalisé à l’aide signaux extraits des interactions mais également avec des signaux obtenus avec une synthèse adaptative basé sur la modélisation HNM. Nous avons obtenus des résultats comparables démontrant ainsi la qualité de notre synthèse adaptative<br>The work presented in this manuscript is based on the study of a phenomenon called phonetic convergence which postulates that two people in interaction will tend to adapt how they talk to their partner in a communicative purpose. We have developed a paradigm called “Verbal Dominoes“ to collect a large corpus to characterize this phenomenon, the ultimate goal being to fill a conversational agent of this adaptability in order to improve the quality of human-machine interactions.We have done several studies to investigate the phenomenon between pairs of unknown people, good friends, and between people coming from the same family. We expect that the amplitude of convergence is proportional to the social distance between the two speakers. We found this result. Then, we have studied the knowledge of the linguistic target impact on adaptation. To characterize the phonetic convergence, we have developed two methods: the first one is based on a linear discriminant analysis between the MFCC coefficients of each speaker and the second one used speech recognition techniques. The last method will allow us to study the phenomenon in less controlled conditions.Finally, we characterized the phonetic convergence with a subjective measurement using a new perceptual test called speaker switching. The test was performed using signals coming from real interactions but also with synthetic data obtained with the harmonic plus
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Hughes, Roger Brett. "Automated interactive software verification and synthesis." Thesis, Brunel University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306741.

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Bozianu, Rodica. "Synthèse des systèmes réactifs interactifs." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241954.

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Nous étudions le problème de la synthèse automatique de programmes dans des architectures multi-composants tels qu'elles respectent les spécifications par construction. Le principal objectif de cette thèse est de développer des procédures pour résoudre le problème de synthèse qui peut conduire à des implémentations efficaces. Chaque composant a une observation partielle sur l'état global du système multi-composants. Le problème est alors de fournir des protocoles basés sur les observations tel que les composants synthétisés assurent les spécifications pour tout le comportement de leur environnement.L'environnement peut être antagoniste, ou peut avoir ses propres objectifs et se comporter de façon rationnelle. Nous étudions d'abord le problème de synthèse lorsque l'environnement est présumé antagoniste. Pour ce contexte, nous proposons une procédure "Safraless" pour la synthèse d'un composant partiellement informé et un environnement omniscient à partir de spécifications KLTL+. Elle est implémentée dans l'outil Acacia-K. Ensuite, nous étudions le problème de synthèse lorsque les composants de l'environnement ont leurs propres objectifs et sont rationnels. Pour le cadre plus simple de l'information parfaite, nous fournissons des complexités serrées pour des objectifs oméga-réguliers particuliers. Pour le cas de l'information imparfaite, nous prouvons que le problème de la synthèse rationnelle est indécidable en général, mais nous regagnons la décidabilité si on demande à synthétiser un composant avec observation partielle contre un environnement multi-composante, omniscient et rationnel.<br>Doctorat en Sciences<br>info:eu-repo/semantics/nonPublished
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Tramus, Marie-Hélène. "Dispositifs interactifs d'images de synthèse." Paris 8, 1991. http://www.theses.fr/1991PA080589.

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Cette these est theorique et pratique. Elle comporte la realisation de dispositifs interactifs d'images de synthese (la speakerine de synthese, et la plume) qu'elle situe dans une interrogation sur l'interactivite et dans un panorama des dispositifs existant dans de nombreux domaines (industriels, ludiques et educatifs, et artistiques<br>This rhesis is theoretical and practical. It includes the realisation of interactive installations of synthetic images (la speakerine de synthese et la plume) which takes place in an interrogation on the interactivity and in an installation panorama in industrial, play and artistical activities
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Books on the topic "Synthese interactive"

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Hughes, Roger Brett. Automated interactive software verification and synthesis. Brunel University, 1992.

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Tausworthe, Robert C. Conjuctive programming: An interactive approach to software system synthesis. National Aeronautics and Space Administration, Jet Propulsion Laboratory, California Institute of Technology, 1992.

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Turner, Stephen. Computer-assisted design for organic synthesis: An interactive teaching package. Wiley, 1987.

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Atlas forestier interactif du Cameroun (version 2.0): Document de synthèse. 2nd ed. World Resources Institute, 2007.

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United States. Federal Motor Carrier Safety Administration. Office of Research and Analysis. Highway/heavy vehicle interaction: A synthesis of safety practice. U.S. Dept. of Transportation, Federal Motor Carrier Safety Administration, Office of Research and Analysis, 2007.

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Garcia, Gérald. Advances in Computer Graphics: Images: Synthesis, Analysis, and Interaction. Springer Berlin Heidelberg, 1991.

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Jacob, Réal. La PME apprenante: Information, connaissance, interaction, intelligence : rapport de veille-synthèse. Développement économique Canada, 2000.

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Guntrip, Harry. Personality structure and human interaction: The developing synthesis of psychodynamic theory. Karnac, 1995.

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Personality Structure and Human Interaction: The Developing Synthesis of Psychodynamic Theory. Taylor and Francis, 2018.

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Knirel, Yuriy A., and Miguel A. Valvano. Bacterial lipopolysaccharides: Structure, chemical synthesis, biogenesis, and interaction with host cells. Springer, 2011.

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Book chapters on the topic "Synthese interactive"

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Koenig, Reinhard, Yufan Miao, Katja Knecht, Peter Buš, and Chang Mei-Chih. "Interactive Urban Synthesis." In Communications in Computer and Information Science. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5197-5_2.

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Hippe, Z. S. "Human Interaction in Planning Chemical Syntheses. Some Problems of Retro-Synthesis." In Human-Computer Systems Interaction. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62120-3_6.

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Ferreira, Margarida, Miguel Terra-Neves, Miguel Ventura, Inês Lynce, and Ruben Martins. "FOREST: An Interactive Multi-tree Synthesizer for Regular Expressions." In Tools and Algorithms for the Construction and Analysis of Systems. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-72016-2_9.

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AbstractForm validators based on regular expressions are often used on digital forms to prevent users from inserting data in the wrong format. However, writing these validators can pose a challenge to some users.We present Forest, a regular expression synthesizer for digital form validations. Forest produces a regular expression that matches the desired pattern for the input values and a set of conditions over capturing groups that ensure the validity of integer values in the input. Our synthesis procedure is based on enumerative search and uses a Satisfiability Modulo Theories (SMT) solver to explore and prune the search space. We propose a novel representation for regular expressions synthesis, multi-tree, which induces patterns in the examples and uses them to split the problem through a divide-and-conquer approach. We also present a new SMT encoding to synthesize capture conditions for a given regular expression. To increase confidence in the synthesized regular expression, we implement user interaction based on distinguishing inputs.We evaluated Forest on real-world form-validation instances using regular expressions. Experimental results show that Forest successfully returns the desired regular expression in 70% of the instances and outperforms Regel, a state-of-the-art regular expression synthesizer.
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Meskhidze, Helen. "(What) Do We Learn from Code Comparisons? A Case Study of Self-Interacting Dark Matter Implementations." In Synthese Library. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-26618-8_10.

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AbstractThere has been much interest in the recent philosophical literature on increasing the reliability and trustworthiness of computer simulations. One method used to investigate the reliability of computer simulations is code comparison. Gueguen, however, has offered a convincing critique of code comparisons, arguing that they face a critical tension between the diversity of codes required for an informative comparison and the similarity required for the codes to be comparable. Here, I reflect on her critique in light of a recent code comparison investigating self-interacting dark matter in two computer simulation codes. I argue that the informativeness of this particular code comparison was due to its targeted approach and narrow focus. Its targeted approach (i.e., only the dark matter modules) allowed for simulation outputs that were diverse enough for an informative comparison and yet still comparable. Understanding the comparison as an instance of eliminative reasoning narrowed the focus: we could investigate whether code-specific differences in implementation contributed significantly to the results of self-interacting dark matter simulations. Based on this case study, I argue that code comparisons can be conducted in such a way that they serve as a method for increasing our confidence in computer simulations being, as Parker defines, adequate-for-purpose.
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Yamada, Shinji. "Organic Synthesis". У The Cation–π Interaction. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-7335-2_4.

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Okwechime, Dumebi, Eng-Jon Ong, Andrew Gilbert, and Richard Bowden. "Social Interactive Human Video Synthesis." In Computer Vision – ACCV 2010. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19315-6_20.

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Schmidt, Joshua, Sebastian Krings, and Michael Leuschel. "Interactive Model Repair by Synthesis." In Lecture Notes in Computer Science. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33600-8_25.

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Gvero, Tihomir, Viktor Kuncak, and Ruzica Piskac. "Interactive Synthesis of Code Snippets." In Computer Aided Verification. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22110-1_33.

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Gammie, Peter. "Verified Synthesis of Knowledge-Based Programs in Finite Synchronous Environments." In Interactive Theorem Proving. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-22863-6_9.

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Miculan, Marino, and Marco Paviotti. "Synthesis of Distributed Mobile Programs Using Monadic Types in Coq." In Interactive Theorem Proving. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-32347-8_13.

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Conference papers on the topic "Synthese interactive"

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Jain, Sumit, and C. Karen Liu. "Interactive synthesis of human-object interaction." In the 2009 ACM SIGGRAPH/Eurographics Symposium. ACM Press, 2009. http://dx.doi.org/10.1145/1599470.1599476.

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Rybarova, Renata, Ivan Drozd, and Gregor Rozinaj. "GUI for interactive speech synthesis." In 2016 International Conference on Systems, Signals and Image Processing (IWSSIP). IEEE, 2016. http://dx.doi.org/10.1109/iwssip.2016.7502776.

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Leung, Alan, John Sarracino, and Sorin Lerner. "Interactive parser synthesis by example." In PLDI '15: ACM SIGPLAN Conference on Programming Language Design and Implementation. ACM, 2015. http://dx.doi.org/10.1145/2737924.2738002.

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Zhou, Zhanhui, Man To Tang, Qiping Pan, Shangyin Tan, Xinyu Wang, and Tianyi Zhang. "INTENT: Interactive Tensor Transformation Synthesis." In UIST '22: The 35th Annual ACM Symposium on User Interface Software and Technology. ACM, 2022. http://dx.doi.org/10.1145/3526113.3545653.

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Larochelle, Pierre M. "Interactive Visualization of Spatial Triangles." In ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/detc2022-90056.

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Abstract This article presents a novel software tool for the interactive visualization of spatial triangles. These triangles serve as the geometric foundation for spatial mechanism design; both synthesis and analysis. Moreover, the conceptualization and visualization of triangles facilitate the mastery of the synthesis and analysis of spatial mechanisms. This interactive visualization tool has been developed to facilitate the teaching and learning of spatial mechanisms at the graduate and undergraduate levels. The trigonometry employed and the interactive MATLAB implementation are presented. It is hoped that the dissemination of this software tool will facilitate the learning and advancement of spatial mechanism design techniques.
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Thatch, B. R., and A. Myklebust. "A PHIGS-Based Graphics Input Interface for Spatial Mechanism Design." In ASME 1987 Design Technology Conferences. American Society of Mechanical Engineers, 1987. http://dx.doi.org/10.1115/detc1987-0049.

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Abstract Creation of input specifications for synthesis or analysis of spatial mechanisms can be a significant problem. A graphics preprocessor which interactively assists in the definition of spatial mechanism problems is described. New methods of depth cucing and six DOF data entry are presented. To achieve graphics device-independence, the proposed graphics standard PHIGS (Programmer’s Hierarchical Interactive Graphics System) is used. Examples of application are presented including generation of input commands for Integrated Mechanisms Program (IMP) and generation of input for spatial mechanism synthesis routines.
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Dong, Weiming, Ning Zhou, and Jean-Claude Paul. "Interactive Example-Based Natural Scene Synthesis." In 2009 Third International Symposium on Plant Growth Modeling, Simulation, Visualization and Applications (PMA). IEEE, 2009. http://dx.doi.org/10.1109/pma.2009.50.

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Mukai, Tomohiko. "Motion rings for interactive gait synthesis." In Symposium on Interactive 3D Graphics and Games. ACM Press, 2011. http://dx.doi.org/10.1145/1944745.1944767.

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Barman, Shaon, Rastislav Bodik, Satish Chandra, Emina Torlak, Arka Bhattacharya, and David Culler. "Toward tool support for interactive synthesis." In SPLASH '15: Conference on Systems, Programming, Languages, and Applications: Software for Humanity. ACM, 2015. http://dx.doi.org/10.1145/2814228.2814235.

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Zhang, Tianyi, London Lowmanstone, Xinyu Wang, and Elena L. Glassman. "Interactive Program Synthesis by Augmented Examples." In UIST '20: The 33rd Annual ACM Symposium on User Interface Software and Technology. ACM, 2020. http://dx.doi.org/10.1145/3379337.3415900.

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Reports on the topic "Synthese interactive"

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McIntosh, Samuel C., Floyd Jr., and Michel A. Investigation of Interactive Structural and Controller Synthesis for Large Spacecraft. Defense Technical Information Center, 1986. http://dx.doi.org/10.21236/ada172811.

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Richard L. Blanton. The Dictyostelium discoideum cellulose synthase: Structure/function analysis and identification of interacting proteins. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/821393.

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Murty A. Akundi. Quarterly Technical Progress Report - Investigation of Syngas Interaction in Alcohol Synthesis Catalysts. Office of Scientific and Technical Information (OSTI), 1998. http://dx.doi.org/10.2172/1625.

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Yaremchuk, Olesya. TRAVEL ANTHROPOLOGY IN JOURNALISM: HISTORY AND PRACTICAL METHODS. Ivan Franko National University of Lviv, 2021. http://dx.doi.org/10.30970/vjo.2021.49.11069.

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Our study’s main object is travel anthropology, the branch of science that studies the history and nature of man, socio-cultural space, social relations, and structures by gathering information during short and long journeys. The publication aims to research the theoretical foundations and genesis of travel anthropology, outline its fundamental principles, and highlight interaction with related sciences. The article’s defining objectives are the analysis of the synthesis of fundamental research approaches in travel anthropology and their implementation in journalism. When we analyze what methods are used by modern authors, also called «cultural observers», we can return to the localization strategy, namely the centering of the culture around a particular place, village, or another spatial object. It is about the participants-observers and how the workplace is limited in space and time and the broader concept of fieldwork. Some disciplinary practices are confused with today’s complex, interactive cultural conjunctures, leading us to think of a laboratory of controlled observations. Indeed, disciplinary approaches have changed since Malinowski’s time. Based on the experience of fieldwork of Svitlana Aleksievich, Katarzyna Kwiatkowska-Moskalewicz, or Malgorzata Reimer, we can conclude that in modern journalism, where the tools of travel anthropology are used, the practical methods of complexity, reflexivity, principles of openness, and semiotics are decisive. Their authors implement both for stable localization and for a prevailing transition.
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Akundi, MA. Investigation of syngas interaction in alcohol synthesis catalysts. Quarterly technical progress report, October 1,1995--December 31, 1995. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/233294.

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Pendall, Elise, Kiona Ogle, and William Parton. Data-model synthesis of grassland carbon metabolism. Quantifying direct, indirect & interactive effects of warming & elevated CO2. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1239688.

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Horwitz, Benjamin A., and Barbara Gillian Turgeon. Fungal Iron Acquisition, Oxidative Stress and Virulence in the Cochliobolus-maize Interaction. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7709885.bard.

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Our project focused on genes for high affinity iron acquisition in Cochliobolus heterostrophus, a necrotrophic pathogen of maize, and their intertwined relationship to oxidative stress status and virulence of the fungus on the host. An intriguing question was why mutants lacking the nonribosomal peptide synthetase (NRPS) gene (NPS6) responsible for synthesis of the extracellular siderophore, coprogen, are sensitive to oxidative stress. Our overall objective was to understand the mechanistic connection between iron stress and oxidative stress as related to virulence of a plant pathogen to its host. The first objective was to examine the interface where small molecule peptide and reactive oxygen species (ROS) mechanisms overlap. The second objective was to determine if the molecular explanation for common function is common signal transduction pathways. These pathways, built around sensor kinases, response regulators, and transcription factors may link sequestering of iron, production of antioxidants, resistance to oxidative stress, and virulence. We tested these hypotheses by genetic manipulation of the pathogen, virulence assays on the host plant, and by following the expression of key fungal genes. An addition to the original program, made in the first year, was to develop, for fungi, a genetically encoded indicator of redox state based on the commercially available Gfp-based probe pHyper, designed for animal cell biology. We implemented several tools including a genetically encoded indicator of redox state, a procedure to grow iron-depleted plants, and constructed a number of new mutants in regulatory genes. Lack of the major Fe acquisition pathways results in an almost completely avirulent phenotype, showing how critical Fe acquisition is for the pathogen to cause disease. Mutants in conserved signaling pathways have normal ability to regulate NPS6 in response to Fe levels, as do mutants in Lae1 and Vel1, two master regulators of gene expression. Vel1 mutants are sensitive to oxidative stress, and the reason may be underexpression of a catalase gene. In nps6 mutants, CAT3 is also underexpressed, perhaps explaining the sensitivity to oxidative stress. We constructed a deletion mutant for the Fe sensor-regulator SreA and found that it is required for down regulation of NPS6 under Fe-replete conditions. Lack of SreA, though, did not make the fungus over-sensitive to ROS, though the mutant had a slow growth rate. This suggests that overproduction of siderophore under Fe-replete conditions is not very damaging. On the other hand, increasing Fe levels protected nps6 mutants from inhibition by ROS, implying that Fe-catalyzed Fenton reactions are not the main factor in its sensitivity to ROS. We have made some progress in understanding why siderophore mutants are sensitive to oxidative stress, and in doing so, defined some novel regulatory relationships. Catalase genes, which are not directly related to siderophore biosynthesis, are underexpressed in nps6 mutants, suggesting that the siderophore product (with or without bound Fe) may act as a signal. Siderophores, therefore, could be a target for intervention in the field, either by supplying an incorrect signal or blocking a signal normally provided during infection. We already know that nps6 mutants cause smaller lesions and have difficulty establishing invasive growth in the host. Lae1 and Vel1 are the first factors shown to regulate both super virulence conferred by T-toxin, and basic pathogenicity, due to unknown factors. The mutants are also altered in oxidative stress responses, key to success in the infection court, asexual and sexual development, essential for fungal dissemination in the field, aerial hyphal growth, and pigment biosynthesis, essential for survival in the field. Mutants in genes encoding NADPH oxidase (Nox) are compromised in development and virulence. Indeed the triple mutant, which should lack all Nox activity, was nearly avirulent. Again, gene expression experiments provided us with initial evidence that superoxide produced by the fungus may be most important as a signal. Blocking oxidant production by the pathogen may be a way to protect the plant host, in interactions with necrotrophs such as C. heterostrophus which seem to thrive in an oxidant environment.
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Hasanzadeh, Sogand, Mirian Velay-Lizancos, Woei-Chyi Chang, Marina Lopez-Arias, and Vito Francioso. Synthesis Study of Best Practices for Cleaning Tools and Paving Equipment: Asphalt Release Agents (ARAs) and Asphalt Cleaners (ACs). Purdue University, 2022. http://dx.doi.org/10.5703/1288284317381.

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Diesel has been used widely as an asphalt cleaning agent due to its effectiveness for many years. However, its negative impact on health and the environment calls for more sustainable and safe alternatives. Asphalt Release Agents (ARAs) are products for preventing or mitigating undesirable adhesion of HMA to the asphalt equipment, and Asphalt Cleaners (ACs) are products for remediation when the adhesion has already happened. In this study, commercially ARAs and ACs reported by NTPEP and U.S. DOTs are quantitatively and qualitatively examined based on the following criteria: (1) cost-effectiveness, (2) functionality, (3) environmental, and (4) safety considerations. The results provided valuable insights into cost-effective products; and ultimately led to developing an interactive decision-making dashboard to help INDOT make more informed decisions regarding testing and investing in these alternatives.
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Akundi, M. A. Investigation of syngas interaction in alcohol synthesis catalysts. Quarterly technical progress report, January 1, 1995--March 31, 1995. Office of Scientific and Technical Information (OSTI), 1995. http://dx.doi.org/10.2172/116681.

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Akundi, M. A. Investigation of syngas interaction in alcohol synthesis catalysts. Quartery technical progress report, July 1, 1995--September 31, 1995. Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/196531.

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