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Journal articles on the topic 'Synthese interactive'

Author: Grafiati

Published: 24 August 2023

Last updated: 31 July 2025

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1

Spikes, Tobias E., Martin G. Montgomery, and John E. Walker. "Interface mobility between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes." Proceedings of the National Academy of Sciences 118, no. 8 (2021): e2021012118. http://dx.doi.org/10.1073/pnas.2021012118.

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The ATP synthase complexes in mitochondria make the ATP required to sustain life by a rotary mechanism. Their membrane domains are embedded in the inner membranes of the organelle, and they dimerize via interactions between their membrane domains. The dimers form extensive chains along the tips of the cristae with the two rows of monomeric catalytic domains extending into the mitochondrial matrix at an angle to each other. Disruption of the interface between dimers by mutation affects the morphology of the cristae severely. By analysis of particles of purified dimeric bovine ATP synthase by cr

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2

Weber, Ute, Laszlo Zsolnai, and Gottfried Hüttner. "Synthesen und Strukturen von Distibankomplexen / Syntheses and Structures of Distibane Complexes." Zeitschrift für Naturforschung B 40, no. 11 (1985): 1430–36. http://dx.doi.org/10.1515/znb-1985-1103.

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Stibanes RSbHal2 are reductivly coupled by interaction with Na2M2(CO)10 (M = Cr, W) or Cp(CO)2MnTHF. The resulting distibanes RS̲b̲(Hal)-(Hal)S̲b̲R are coordinated to sixteen electron LnM-fragments (LnM=M(CO)5, Cp(CO)2Mn). Both the meso and d/l stereoisomeres are structurally characterised by X-ray analyses.

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3

Li, Chunhong, Sreelatha Sarangapani, Qian Wang, Kumar Nadimuthu, and Rajani Sarojam. "Metabolic Engineering of the Native Monoterpene Pathway in Spearmint for Production of Heterologous Monoterpenes Reveals Complex Metabolism and Pathway Interactions." International Journal of Molecular Sciences 21, no. 17 (2020): 6164. http://dx.doi.org/10.3390/ijms21176164.

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Spearmint produces and stores large amounts of monoterpenes, mainly limonene and carvone, in glandular trichomes and is the major natural source of these compounds. Towards producing heterologous monoterpenes in spearmint, we first reduced the flux into the native limonene pathway by knocking down the expression of limonene synthase (MsLS) by RNAi method. The MsLS RNAi lines exhibited a huge reduction in the synthesis of limonene and carvone. Detailed GC-MS and LC-MS analysis revealed that MsLS RNAi plants also showed an increase in sesquiterpene, phytosterols, fatty acids, flavonoids, and phe

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4

Fan, Zeyu, Xinhao Li, Ruoyu Jiang, et al. "Molecular Dynamics Simulation Reveal the Structure–Activity Relationships of Kainoid Synthases." Marine Drugs 22, no. 7 (2024): 326. http://dx.doi.org/10.3390/md22070326.

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Kainoid synthases are key enzymes in the biosynthesis of kainoids. Kainoids, as represented by DA and KA, are a class of naturally occurring non-protein amino acids with strong neurotransmitter activity in the mammalian central nervous system. Marine algae kainoid synthases include PnDabC from diatoms, which synthesizes domoic acid (DA), and DsKabC and GfKabC from red algae, which synthesize kainic acid (KA). Elucidation of the catalytic mechanism of kainoid synthases is of great significance for the rational design of better biocatalysts to promote the industrial production of kainoids for us

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Moolhuijzen, Paula M., Mariano Jordi Muria-Gonzalez, Robert Syme, et al. "Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp." Toxins 12, no. 4 (2020): 242. http://dx.doi.org/10.3390/toxins12040242.

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Pyrenophora is a fungal genus responsible for a number of major cereal diseases. Although fungi produce many specialised or secondary metabolites for defence and interacting with the surrounding environment, the repertoire of specialised metabolites (SM) within Pyrenophora pathogenic species remains mostly uncharted. In this study, an in-depth comparative analysis of the P. teres f. teres, P teres f. maculata and P. tritici-repentis potential to produce SMs, based on in silico predicted biosynthetic gene clusters (BGCs), was conducted using genome assemblies from PacBio DNA reads. Conservation

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Webby, Celia J., Mark L. Patchett, and Emily J. Parker. "Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori." Biochemical Journal 390, no. 1 (2005): 223–30. http://dx.doi.org/10.1042/bj20050259.

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DAH7P (3-Deoxy-D-arabino-heptulosonate 7-phosphate) synthase catalyses the condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) as the first committed step in the biosynthesis of aromatic compounds in plants and micro-organisms. Previous work has identified two families of DAH7P synthases based on sequence similarity and molecular mass, with the majority of the mechanistic and structural studies being carried out on the type I paralogues from Escherichia coli. Whereas a number of organisms possess genes encoding both type I and type II DAH7P synthases, the

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7

Biuković, Goran, Sandip Basak, Malathy Sony Subramanian Manimekalai та ін. "Variations of Subunit ε of the Mycobacterium tuberculosis F1FoATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207". Antimicrobial Agents and Chemotherapy 57, № 1 (2012): 168–76. http://dx.doi.org/10.1128/aac.01039-12.

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ABSTRACTThe subunit ε of bacterial F1FOATP synthases plays an important regulatory role in coupling and catalysis via conformational transitions of its C-terminal domain. Here we present the first low-resolution solution structure of ε ofMycobacterium tuberculosis(Mtε) F1FOATP synthase and the nuclear magnetic resonance (NMR) structure of its C-terminal segment (Mtε103–120).Mtε is significantly shorter (61.6 Å) than forms of the subunit in other bacteria, reflecting a shorter C-terminal sequence, proposed to be important in coupling processes via the catalytic β subunit. The C-terminal segment

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8

Mühleip, Alexander W., Friederike Joos, Christoph Wigge, Achilleas S. Frangakis, Werner Kühlbrandt, and Karen M. Davies. "Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria." Proceedings of the National Academy of Sciences 113, no. 30 (2016): 8442–47. http://dx.doi.org/10.1073/pnas.1525430113.

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F1Fo-ATP synthases are universal energy-converting membrane protein complexes that synthesize ATP from ADP and inorganic phosphate. In mitochondria of yeast and mammals, the ATP synthase forms V-shaped dimers, which assemble into rows along the highly curved ridges of lamellar cristae. Using electron cryotomography and subtomogram averaging, we have determined the in situ structure and organization of the mitochondrial ATP synthase dimer of the ciliate Paramecium tetraurelia. The ATP synthase forms U-shaped dimers with parallel monomers. Each complex has a prominent intracrista domain, which l

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9

Sotodosos-Alonso, Laura, María García-García, Enrique Calvo, et al. "Cell tension controlling pathways and nutrient availability regulate plasma membrane ATP synthase trafficking." IBJ Plus 1, s5 (2022): 45. http://dx.doi.org/10.24217/2531-0151.22v1s5.00045.

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Introduction: The interplay between mechanical stress and cell metabolism is an emerging topic. However, the mechanotransduction pathways coordinating cell metabolism to the tensional status of the cell are poorly understood. Here, we provide several evidences suggesting that caveolae – mechanosensitive plasma membrane invaginations-, nutrient availability and cell tension controlling conditions are important for the biology of mitochondrial ATP synthase. Material and Methods: For achieving the caveolar interactome, plasma membrane biotinylation and co-localization experiments, we have used hu

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10

Gu, Ying, and Chris Somerville. "Cellulose synthase interacting protein." Plant Signaling & Behavior 5, no. 12 (2010): 1571–74. http://dx.doi.org/10.4161/psb.5.12.13621.

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11

Rode, W., and A. Leś. "Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP." Acta Biochimica Polonica 43, no. 1 (1996): 133–42. http://dx.doi.org/10.18388/abp.1996_4524.

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Thymidylate synthase is a target enzyme in anticancer, antiviral, antifungal and antiprotozoan chemotherapy. With two dUMP analogues, 5-fluoro-dUMP (FdUMP) and 5-(trifluoromethyl)-dUMP (CF3dUMP), strong thymidylate synthase inhibitors and active forms of drugs, the inhibition mechanism is based on the reaction mechanism. Recent comparative studies of new dUMP analogues, containing more than one substituent in the pyrimidine ring, showed that substitution of the pyrimidine ring C(4) = O group in FdUMP by either C(4) = N-OH group (in N4-hydroxy-FdCMP) or C(4) = S group (in 4-thio-FdUMP) preserve

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12

Volk, Kathrin, Sven D. Breunig, Raphaela Rid, et al. "Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein." Biological Chemistry 398, no. 1 (2017): 125–33. http://dx.doi.org/10.1515/hsz-2016-0185.

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Abstract Acyl-carrier-protein (acpP) is an essential protein in fatty acid biosynthesis of Staphylococcus aureus [Cronan, J.E. and Thomas, J. (2009). Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. Method. Enzymol. 459, 395–433; Halavaty, A.S., Kim, Y., Minasov, G., Shuvalova, L., Dubrovska, I., Winsor, J., Zhou, M., Onopriyenko, O., Skarina, T., Papazisi, L., et al. (2012). Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria. Acta Crystallogr. Sect. D Biol. Crystallogr. 68

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Li, S., L. Lei, C. R. Somerville, and Y. Gu. "Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes." Proceedings of the National Academy of Sciences 109, no. 1 (2011): 185–90. http://dx.doi.org/10.1073/pnas.1118560109.

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14

IEMURA, Shun-ichiro, and Tohru NATSUME. "A systematic analysis of protein interaction networks leading to the drug discovery." Synthesiology English edition 1, no. 2 (2008): 114–20. http://dx.doi.org/10.5571/syntheng.1.114.

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15

Osipov, Stepan D., Yury L. Ryzhykau, Egor V. Zinovev, et al. "I-Shaped Dimers of a Plant Chloroplast FOF1-ATP Synthase in Response to Changes in Ionic Strength." International Journal of Molecular Sciences 24, no. 13 (2023): 10720. http://dx.doi.org/10.3390/ijms241310720.

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F-type ATP synthases play a key role in oxidative and photophosphorylation processes generating adenosine triphosphate (ATP) for most biochemical reactions in living organisms. In contrast to the mitochondrial FOF1-ATP synthases, those of chloroplasts are known to be mostly monomers with approx. 15% fraction of oligomers interacting presumably non-specifically in a thylakoid membrane. To shed light on the nature of this difference we studied interactions of the chloroplast ATP synthases using small-angle X-ray scattering (SAXS) method. Here, we report evidence of I-shaped dimerization of solub

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16

Zhu, Xiaoyu, Shundai Li, Songqin Pan, Xiaoran Xin, and Ying Gu. "CSI1, PATROL1, and exocyst complex cooperate in delivery of cellulose synthase complexes to the plasma membrane." Proceedings of the National Academy of Sciences 115, no. 15 (2018): E3578—E3587. http://dx.doi.org/10.1073/pnas.1800182115.

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Cellulose synthesis occurs exclusively at the plasma membrane by cellulose synthase complexes (CSCs). Therefore, delivery of CSCs to discrete sites at the plasma membrane is critical for cellulose synthesis. Despite their significance, the delivery of CSCs is poorly understood. Here we used proteomics approaches, functional genetics, and live cell imaging to show that the de novo secretion of CSCs is mediated by cooperation among cellulose synthase interactive 1 (CSI1), the plant-specific protein PATROL1, and exocyst complex in Arabidopsis thaliana. We propose that CSI1 plays a role in marking

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17

Gorska-Ponikowska, Magdalena, Alicja Kuban-Jankowska, Antonella Marino Gammazza, et al. "The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model." International Journal of Molecular Sciences 21, no. 2 (2020): 616. http://dx.doi.org/10.3390/ijms21020616.

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2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials. However, the mechanism of anticancer action of 2-methoxyestradiol has not been yet fully established. In our previous studies we have demonstrated that 2-methoxyestradiol selectively induces the expression and nuclear translocation of neuronal nitric oxide synthase in osteosarcoma 143B cells. Heat shock proteins (Hsps) are factors involved in the regulation of expression and activity of nitric oxide synthases. Herein,

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18

Martin, Dominic A., Myriam Pham-Truffert, Lara Gillham, et al. "Interactive visual syntheses for social-ecological systems understanding." Socio-Environmental Systems Modelling 6 (April 27, 2024): 18637. http://dx.doi.org/10.18174/sesmo.18637.

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Many social-ecological systems are in an unsustainable state. Bringing together disjunct published findings on complex interactions in social-ecological systems may enable the identification of leverage points for transformations towards sustainability. However, such interdisciplinary synthesis studies on specific regional social-ecological systems remain rare. Here, we pair a review of systematically identified studies with a cross-impact analysis to create an interactive visual social-ecological systems synthesis on conflicts and synergies between land use, biodiversity conservation, and hum

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19

Su, Zenghua, Michael A. Blazing, Daju Fan, and Samuel E. George. "The Calmodulin-Nitric Oxide Synthase Interaction." Journal of Biological Chemistry 270, no. 49 (1995): 29117–22. http://dx.doi.org/10.1074/jbc.270.49.29117.

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20

Sumegi, B., H. F. Gilbert, and P. A. Srere. "Interaction between citrate synthase and thiolase." Journal of Biological Chemistry 260, no. 1 (1985): 188–90. http://dx.doi.org/10.1016/s0021-9258(18)89713-7.

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21

Skurat, Alexander V., Amy D. Dietrich, and Peter J. Roach. "Interaction between glycogenin and glycogen synthase." Archives of Biochemistry and Biophysics 456, no. 1 (2006): 93–97. http://dx.doi.org/10.1016/j.abb.2006.09.024.

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22

Claypool, Steven M., Pinmanee Boontheung, J. Michael McCaffery, Joseph A. Loo, and Carla M. Koehler. "The Cardiolipin Transacylase, Tafazzin, Associates with Two Distinct Respiratory Components Providing Insight into Barth Syndrome." Molecular Biology of the Cell 19, no. 12 (2008): 5143–55. http://dx.doi.org/10.1091/mbc.e08-09-0896.

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Mutations in the mitochondrial cardiolipin (CL) transacylase, tafazzin (Taz1p), result in the X-linked cardioskeletal myopathy, Barth syndrome (BTHS). The mitochondria of BTHS patients exhibit variable respiratory defects and abnormal cristae ultrastructure. The biochemical basis for these observations is unknown. In the absence of its target phospholipid, CL, a very large Taz1p complex is missing, whereas several discrete smaller complexes are still observed. None of the identified Taz1p complexes represents Taz1p homodimers. Instead, yeast Taz1p physically assembles in several protein comple

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23

Hyndman, Mathew Eric, Subodh Verma, Robin J. Rosenfeld, Todd J. Anderson, and Howard G. Parsons. "Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 6 (2002): H2167—H2172. http://dx.doi.org/10.1152/ajpheart.00935.2001.

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The present study was designed to investigate the interaction between 5-methyltetrahydrofolate and tetrahydrobiopterin in modulating endothelial function. Tetrahydrobiopterin is a critical cofactor for nitric oxide synthase and maintains this enzyme as a nitric oxide- versus superoxide-producing enzyme. The structure of 5-methyltetrahydrofolate is similar to tetrahydrobiopterin and both agents have been shown to improve endothelium-dependent vasodilatation. We hypothesized that 5-methyltetrahydrofolate interacts with nitric oxide synthase in a fashion analogous, yet independent, of tetrahydrob

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Fenton, Andrew K., Sylvie Manuse, Josué Flores-Kim, et al. "Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacP." Proceedings of the National Academy of Sciences 115, no. 11 (2018): 2812–17. http://dx.doi.org/10.1073/pnas.1715218115.

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Most bacterial cells are surrounded by an essential cell wall composed of the net-like heteropolymer peptidoglycan (PG). Growth and division of bacteria are intimately linked to the expansion of the PG meshwork and the construction of a cell wall septum that separates the nascent daughter cells. Class A penicillin-binding proteins (aPBPs) are a major family of PG synthases that build the wall matrix. Given their central role in cell wall assembly and importance as drug targets, surprisingly little is known about how the activity of aPBPs is controlled to properly coordinate cell growth and div

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Malathi, K., Y. Xiao, and A. P. Mitchell. "Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p." Molecular and Cellular Biology 17, no. 12 (1997): 7230–36. http://dx.doi.org/10.1128/mcb.17.12.7230.

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Meiosis and expression of early meiotic genes in the budding yeast Saccharomyces cerevisiae depend upon Rim11p, Ume6p, and Ime1p. Rim11p (also called Mds1p and ScGSK3) is a protein kinase related to glycogen synthase kinase 3 (GSK3); Ume6p is an architectural transcription factor; and Imelp is a Ume6p-binding protein that provides a transcriptional activation domain. Rim11p is required for Ime1p-Ume6p interaction, and prior studies have shown that Rim11p binds to and phosphorylates Ime1p. We show here that Rim11p binds to and phosphorylates Ume6p, as well. Amino acid substitutions in Ume6p tha

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26

Amore, A., R. Bonaudo, D. Ghigo, et al. "Enhanced production of nitric oxide by blood-dialysis membrane interaction." Journal of the American Society of Nephrology 6, no. 4 (1995): 1278–83. http://dx.doi.org/10.1681/asn.v641278.

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Nitric oxide (NO) is a powerful vasoactive product of endothelial origin, and one of its major effects is vasodilation, leading to hypotension. The role of NO in some complications of uremia is still debated. This study evaluated whether endothelial NO synthase activity could be modulated by the exposure of healthy blood to hemodialysis materials. In vitro hemodialysis sessions were performed with cuprophan and polymethylmethacrylate membranes. Blood samples from a healthy donor after recirculation for 0, 5, 15, 30, and 60 min were coincubated for 6 h with a murine endothelial cell line (t.End

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Peluso, John J., Xiufang Liu та Jonathan Romak. "Progesterone Maintains Basal Intracellular Adenosine Triphosphate Levels and Viability of Spontaneously Immortalized Granulosa Cells by Promoting an Interaction between 14-3-3σ and ATP Synthaseβ/Precursor through a Protein Kinase G-Dependent Mechanism". Endocrinology 148, № 5 (2007): 2037–44. http://dx.doi.org/10.1210/en.2006-1603.

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The present studies were designed to 1) describe changes in both the mitochondrial membrane potential and ATP content of spontaneously immortalized granulosa cells as they undergo apoptosis, 2) identify some of the downstream events that are activated by progesterone (P4), and 3) relate these downstream events to changes in mitochondrial function and apoptotic cell death. These studies revealed that in response to serum deprivation, the mitochondrial membrane potential initially hyperpolarizes and ATP content increases. That this increase in ATP is required for apoptosis was demonstrated by th

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DeMarini, Douglas J., Alison E. M. Adams, Hanna Fares, et al. "A Septin-based Hierarchy of Proteins Required for Localized Deposition of Chitin in the Saccharomyces cerevisiae Cell Wall." Journal of Cell Biology 139, no. 1 (1997): 75–93. http://dx.doi.org/10.1083/jcb.139.1.75.

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Just before bud emergence, a Saccharomyces cerevisiae cell forms a ring of chitin in its cell wall; this ring remains at the base of the bud as the bud grows and ultimately forms part of the bud scar marking the division site on the mother cell. The chitin ring seems to be formed largely or entirely by chitin synthase III, one of the three known chitin synthases in S. cerevisiae. The chitin ring does not form normally in temperature-sensitive mutants defective in any of four septins, a family of proteins that are constituents of the “neck filaments” that lie immediately subjacent to the plasma

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He, Jun, Richard A. Fandino, Rayko Halitschke, et al. "An unbiased approach elucidates variation in (S)-(+)-linalool, a context-specific mediator of a tri-trophic interaction in wild tobacco." Proceedings of the National Academy of Sciences 116, no. 29 (2019): 14651–60. http://dx.doi.org/10.1073/pnas.1818585116.

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Plant volatile organic compounds (VOCs) mediate many interactions, and the function of common VOCs is especially likely to depend on ecological context. We used a genetic mapping population of wild tobacco, Nicotiana attenuata, originating from a cross of 2 natural accessions from Arizona and Utah, separated by the Grand Canyon, to dissect genetic variation controlling VOCs. Herbivory-induced leaf terpenoid emissions varied substantially, while green leaf volatile emissions were similar. In a field experiment, only emissions of linalool, a common VOC, correlated significantly with predation of

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Zhao, Zhiguang, Guocang Chen, and Chenglie Zhang. "Interaction between reactive oxygen species and nitric oxide in drought-induced abscisic acid synthesis in root tips of wheat seedlings." Functional Plant Biology 28, no. 10 (2001): 1055. http://dx.doi.org/10.1071/pp00143.

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Abscisic acid accumulation and oxidative stress are two common responses of plants to environmental stresses. However, little is known about their relationships. The purpose of this article is to investigate the effects of reactive oxygen species and nitric oxide on the plant hormone abscisic acid synthesis in root tips of wheat (Triticum aestivum L.) seedlings under drought stress. Detached root tips were subjected to drought stress by naturally evaporating until 20% of their fresh weights were lost. The activities of superoxide synthases and nitric oxide synthase (EC 1.14.13.39) increased af

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Voeller, Donna M., Li-ming Changchien, Gladys F. Maley, et al. "Characterization of a specific interaction betweenEscherichia colithymidylate synthase andEscherichia colithymidylate synthase mRNA." Nucleic Acids Research 23, no. 5 (1995): 869–75. http://dx.doi.org/10.1093/nar/23.5.869.

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Zebarjadian, Yeganeh, Tom King, Maurille J. Fournier, Louise Clarke, and John Carbon. "Point Mutations in Yeast CBF5 Can Abolish In Vivo Pseudouridylation of rRNA." Molecular and Cellular Biology 19, no. 11 (1999): 7461–72. http://dx.doi.org/10.1128/mcb.19.11.7461.

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ABSTRACT In budding yeast (Saccharomyces cerevisiae), the majority of box H/ACA small nucleolar RNPs (snoRNPs) have been shown to direct site-specific pseudouridylation of rRNA. Among the known protein components of H/ACA snoRNPs, the essential nucleolar protein Cbf5p is the most likely pseudouridine (Ψ) synthase. Cbf5p has considerable sequence similarity to Escherichia coli TruBp, a known Ψ synthase, and shares the “KP” and “XLD” conserved sequence motifs found in the catalytic domains of three distinct families of known and putative Ψ synthases. To gain additional evidence on the role of Cb

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Gnedenko, O. V., E. O. Yablokov, P. V. Ershov, et al. "Interaction of prostacyclin synthase with cytochromes P450." Biomeditsinskaya Khimiya 65, no. 1 (2019): 63–66. http://dx.doi.org/10.18097/pbmc20196501063.

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Biosensor experiments on investigation of interaction between prostacyclin synthase (PGIS) and different proteins of the cytochrome P450 monooxygenase systems were perfomed. Interaction of PGIS with microsomal (CYP21A2, CYP2E1) and mitochondrial (CYP27A1, CYP11B1, CYP11B2, CYP11A1) cytochrome P450s was detected. Kinetic and equilibrium parameters of protein complexes formation were determined. Data obtained suggest an essential role of these hemoproteins interaction in regulation of prostacyclin and thromboxane A2 biosynthesis.

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Morgunov, Igor, and Paul A. Srere. "Interaction between Citrate Synthase and Malate Dehydrogenase." Journal of Biological Chemistry 273, no. 45 (1998): 29540–44. http://dx.doi.org/10.1074/jbc.273.45.29540.

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35

Ju, Hong, Rong Zou, Virginia J. Venema, and Richard C. Venema. "Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity." Journal of Biological Chemistry 272, no. 30 (1997): 18522–25. http://dx.doi.org/10.1074/jbc.272.30.18522.

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Li, Zhong, Muhammad Umar Khan, Xue Yan, et al. "Deciphering the Molecular Mechanisms of Chilling Tolerance in Lsi1-Overexpressing Rice." International Journal of Molecular Sciences 23, no. 9 (2022): 4667. http://dx.doi.org/10.3390/ijms23094667.

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Improving tolerance to low-temperature stress during the rice seedling stage is of great significance in agricultural science. In this study, using the low silicon gene 1 (Lsi1)-overexpressing (Dular-OE) and wild-type rice (Dular-WT), we showed that Lsi1 overexpression enhances chilling tolerance in Dular-OE. The overexpression of the Lsi1 increases silicon absorption, but it was not the main reason for chilling tolerance in Dular-OE. Instead, our data suggest that the overexpression of a Lsi1-encoding NIP and its interaction with key proteins lead to chilling tolerance in Dular-OE. Additional

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Raff, H., and B. Jankowski. "Inhibition of aldosterone release by hypoxia in vitro: interaction with carbon monoxide." Journal of Applied Physiology 76, no. 2 (1994): 689–93. http://dx.doi.org/10.1152/jappl.1994.76.2.689.

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We have demonstrated that the aldosteronogenic pathway of the zona glomerulosa is unusually sensitive to modest changes in PO2 (Michaelis constant for O2 approximately 95 Torr). The current study evaluated the interaction of CO (the classic ligand for P-450 enzymes) and the decreases in O2 on aldosteronogenesis in vitro. Bovine adrenocortical zona glomerulosa cells were incubated for 2 h and stimulated with either adenosine 3′,5′-cyclic monophosphate (cAMP) or angiotensin II. Ten and 20% CO led to significant decreases in cAMP- and angiotensin II-stimulated aldosteronogenesis. The combination

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Kluijtmans, Leo A. J., Ian S. Young, Colin A. Boreham, et al. "Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults." Blood 101, no. 7 (2003): 2483–88. http://dx.doi.org/10.1182/blood.v101.7.2483.

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A modestly elevated total plasma homocysteine concentration (tHcy) is generally accepted as an independent and graded risk factor for various pathologies, including vascular diseases, neural tube defects, Alzheimer disease, and pregnancy complications. We analyzed 5 common functional polymorphisms in enzymes involved in homocysteine metabolism (ie, methylenetetrahydrofolate reductase [MTHFR] 677C>T and 1298A>C, methionine synthase [MTR] 2756A>G, cystathionine β-synthase [CBS] 844ins68, and methionine synthase reductase [MTRR] 66A>G) in 452 young adults, and quantified their indepen

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Walters, Jewell N., Justin S. Bickford, Kimberly J. Newsom та ін. "Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ". Biochemical Journal 443, № 2 (2012): 561–71. http://dx.doi.org/10.1042/bj20111801.

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The studies of PGE2 (prostaglandin E2) biosynthesis have focused primarily on the role of cyclo-oxygenases. Efforts have shifted towards the specific PGE2 terminal synthases, particularly mPGES-1 (microsomal PGE synthase 1), which has emerged as the crucial inducible synthase with roles in pain, cancer and inflammation. mPGES-1 is induced by pro-inflammatory cytokines with studies focusing on the proximal promoter, mediated specifically through Egr-1 (early growth-response factor 1). Numerous studies demonstrate that the mPGES-1 promoter (PTGES) alone cannot account for the level of IL-1β (int

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Cruz, Jorddy Neves, Sebastião Gomes Silva, Daniel Santiago Pereira, et al. "In Silico Evaluation of the Antimicrobial Activity of Thymol—Major Compounds in the Essential Oil of Lippia thymoides Mart. & Schauer (Verbenaceae)." Molecules 27, no. 15 (2022): 4768. http://dx.doi.org/10.3390/molecules27154768.

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In this paper, we evaluated the drug-receptor interactions responsible for the antimicrobial activity of thymol, the major compound present in the essential oil (EO) of Lippia thymoides (L. thymoides) Mart. & Schauer (Verbenaceae). It was previously reported that this EO exhibits antimicrobial activity against Candida albicans (C. albicans), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli). Therefore, we used molecular docking, molecular dynamics simulations, and free energy calculations to investigate the interaction of thymol with pharmacological receptors of interest to

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Ogasahara, K., M. Ishida, and K. Yutani. "Subunit-subunit interaction of tryptophan synthase from hyperthermophile." Seibutsu Butsuri 40, supplement (2000): S118. http://dx.doi.org/10.2142/biophys.40.s118_1.

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Wübert, Joachim, Ulrike Oster, and Wolfhart Rüdiger. "Interaction of 5-hydroxymethyl-furfural with hydroxymethylbilane synthase." Phytochemistry 46, no. 1 (1997): 45–50. http://dx.doi.org/10.1016/s0031-9422(97)00215-x.

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Hall, Diane A., Tuajuanda C. Jordan-Starck, Rachel O. Loo, Martha L. Ludwig, and Rowena G. Matthews. "Interaction of Flavodoxin with Cobalamin-Dependent Methionine Synthase†." Biochemistry 39, no. 35 (2000): 10711–19. http://dx.doi.org/10.1021/bi001096c.

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Tsai, A. L., C. H. Wei, and R. J. Kulmacz. "Interaction Between Nitric Oxide and Prostaglandin H Synthase." Archives of Biochemistry and Biophysics 313, no. 2 (1994): 367–72. http://dx.doi.org/10.1006/abbi.1994.1400.

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Cui, Qiang. "Membrane-mediated interaction drives mitochondrial ATPase assembly and cristae formation." Journal of General Physiology 150, no. 6 (2018): 777–80. http://dx.doi.org/10.1085/jgp.201812077.

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Kuncewicz, Teresa, Priya Balakrishnan, Mark B. Snuggs, and Bruce C. Kone. "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages." American Journal of Physiology-Renal Physiology 281, no. 2 (2001): F326—F336. http://dx.doi.org/10.1152/ajprenal.2001.281.2.f326.

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Nitric oxide synthase-2 (NOS2) is responsible for high-output nitric oxide production important in renal inflammation and injury. Using a yeast two-hybrid assay, we identified Rac2, a Rho GTPase member, as a NOS2-interacting protein. NOS2 and Rac2 proteins coimmunoprecipitated from activated RAW 264.7 macrophages. The two proteins colocalized in an intracellular compartment of these cells. Glutathione- S-transferase (GST) pull-down assays revealed that both Rac1 and Rac2 associated with GST-NOS2 and that the NOS2 oxygenase domain was necessary and sufficient for the interaction. [35S]methionin

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Cauich-Carrillo, Regina, Marcela Rosas Nexticapa, Magdalena Alvarez-Ramirez, Maria Virginia Mateu-Armad, Emilio Aguilar-Sanchez, and Lauro Figueroa-Valverde. "In silico evaluation of twenty-five amino derivatives as potential nitric oxide synthase inhibitors." Brazilian Journal of Science 4, no. 8 (2025): 17–34. https://doi.org/10.14295/bjs.v4i8.751.

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There are studies indicating that nitric oxide synthase can be involved in cancer cell growth. It is important to mention that some inhibitors of nitric oxide synthase can produce changes in cancer cell growth. However, there is little information on the interaction of some amino derivatives with nitric oxide synthase surface. The aim of this research was to determine the theoretical interaction of amino derivatives (compounds 1-25) with nitric oxide synthase using the 4d1o protein as a tool. Besides, L-NAME, ONO1714, and N-(3-(aminomethyl)benzyl)acetamidine drugs were used as controls in the

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Frost, David J., Kim Brandt, Tim Kaufmann та Robert Goldman. "Interaction of sulfhydryl reactive reagents with components involved in (1,3)-β-glucan synthesis from Candida albicans". Canadian Journal of Microbiology 41, № 8 (1995): 692–98. http://dx.doi.org/10.1139/m95-095.

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Glucan synthesis was sensitive to several sulfhydryl reacting compounds: mercurials, reversible disulfides, and an alkylating sulfhydryl reagent (IC50 3–45 μM). Thiol groups associated with glucan synthesis were hydrophilic in nature, since both hydrophilic and hydrophobic reagents were active. Glucan synthase complex consists of at least two components: a peripheral GTP-binding protein that can be solubilized with detergents (supernatant) and the catalytic membrane-bound component (pellet). A rapid separation technique was developed to study sulfhydryl interactions with the complex. The GTP-b

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Torgan, C. E., G. J. Etgen, J. T. Brozinick, R. E. Wilcox, and J. L. Ivy. "Interaction of aerobic exercise training and clenbuterol: effects on insulin-resistant muscle." Journal of Applied Physiology 75, no. 4 (1993): 1471–76. http://dx.doi.org/10.1152/jappl.1993.75.4.1471.

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The effects of aerobic exercise training, chronic administration of the selective beta 2-adrenergic agonist clenbuterol, and the combination of these two treatments on muscle insulin resistance were compared in female obese (fa/fa) Zucker rats. Rats were randomly assigned to trained, clenbuterol, clenbuterol-trained, or control groups. Training consisted of treadmill running for 2 h/day at 18 m/min up an 8% grade. Clenbuterol was administered by intubation (0.4–0.8 mg.kg body wt-1 x day-1) approximately 30 min before the rats ran each day. After 8 wk of treatment, muscle insulin resistance was

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Burde, Tali, and Gilad Rimon. "On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1." European Journal of Pharmacology 453, no. 2-3 (2002): 167–73. http://dx.doi.org/10.1016/s0014-2999(02)02450-0.

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