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Journal articles on the topic 'Synthesis. heterocyclic compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Luna, Isadora Silva, Rayssa Marques Duarte da Cruz, Ryldene Marques Duarte da Cruz, Rodrigo Santos Aquino de Araújo, and Francisco Jaime Bezerra Mendonça-Junior. "1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles." Current Organic Synthesis 15, no. 8 (2018): 1026–42. http://dx.doi.org/10.2174/1570179415666180821154551.

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Background: 1,4-Dithiane-2,5-diol (1,4-DTD) is the stable dimer of α-mercapto acetaldehyde. This commercially available ambidentade compound is characterized as having in its chemical structure one group that acts as an electrophile and another that acts as a nucleophile, this permits its use as versatile and efficient synthon in synthetic heterocycle procedures. Objective: The aim of this review is to present synthetic applications of 1,4-DTD in heterocyclic chemistry and their applicability to the synthesis of bioactive compounds. Conclusion: Gewald reactions to obtain C-4 and C-5 unsubstitu

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2

Bakibayev, A. A., K. B. Zhumanov, S. Yu Panshina, et al. "Synthesis methods of phosphorylated carbamide containing acyclic and heterocyclic compounds." Bulletin of the Karaganda University. "Chemistry" series 95, no. 3 (2019): 115–57. http://dx.doi.org/10.31489/2019ch3/115-157.

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3

Adak, Laksmikanta, and Tubai Ghosh. "Recent Progress in Iron-Catalyzed Reactions Towards the Synthesis of Bioactive Five- and Six-Membered Heterocycles." Current Organic Chemistry 24, no. 22 (2020): 2634–64. http://dx.doi.org/10.2174/1385272824999200714102103.

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Heterocyclic compounds are the largely diverse organic molecules and find prevalent applications in the fine chemical industry, medicinal chemistry and agricultural science. They are also among the most commonly bearing frameworks in numerous drugs and pharmaceutical substances. Therefore, the development of convenient, efficient and environmentally benign methods to produce various types of heterocyclic compounds is an attractive area of research. For the synthesis and functionalization of heterocycles, enormous achievements have been attributed over the past decades. Recently, ironcatalyzed

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4

Ābele, E., R. Ābele, Ļ. Golomba, J. Višņevska, T. Beresņeva, and K. Rubina. "Oximes of Seven-Membered Heterocyclic Compounds Containing One Heteroatom." Latvian Journal of Chemistry 50, no. 3-4 (2011): 205–22. http://dx.doi.org/10.2478/v10161-011-0071-7.

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Oximes of Seven-Membered Heterocyclic Compounds Containing One Heteroatom Literature data on the synthesis and structure of azepane, oxepane and thiepane oximes were reviewed. Synthesis of novel heterocycles from oximes of seven-membered heterocycles containing one heteroatom were described. Biological activity of oximes of seven-membered heterocycles with one heteroatom was also reviewed.

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5

Murarka, Sandip, and Andrey Antonchick. "Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates." Synthesis 50, no. 11 (2018): 2150–62. http://dx.doi.org/10.1055/s-0037-1609715.

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Recent years have witnessed a significant advancement in the field of radical oxidative coupling of ketones towards the synthesis of highly useful synthetic building blocks, such as 1,4-dicarbonyl compounds, and biologically important heterocyclic and carbocyclic compounds. Besides oxidative homo- and cross-coupling of enolates, other powerful methods involving direct C(sp3)–H functionalizations of ketones have emerged towards the synthesis of 1,4-dicarbonyl compounds. Moreover, direct α-C–H functionalization of ketones has also allowed an efficient access to carbocycles and heterocycles. Thi

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6

Ābele, E. "Oximes of Seven-Membered Heterocyclic Compounds Containing Two Heteroatoms." Latvian Journal of Chemistry 51, no. 1-2 (2012): 83–92. http://dx.doi.org/10.2478/v10161-012-0005-z.

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Oximes of Seven-Membered Heterocyclic Compounds Containing Two Heteroatoms Literature data concerning the synthesis and structure of diazepane, oxazepane and thiazepane oximes were reviewed. Synthesis of novel heterocycles from the oximes of seven-membered heterocycles containing two heteroatoms was described. Biological activity of oximes of seven-membered heterocycles with two heteroatoms was also reviewed.

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7

Gupta, Vivek Kumar, Baljeet Kaur, Amandeep Kaur, Amanpreet Kaur, and Monika Gupta. "Synthesis and Biological Evaluation of 1,3,4-Oxadiazolyl benzenesulphonyl benzimidazole derivatives." Indian Journal of Pharmaceutical and Biological Research 6, no. 02 (2018): 64–71. http://dx.doi.org/10.30750/ijpbr.6.2.10.

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Oxadiazoles are a class of heterocyclic aromatic chemical compound of azole family. Oxadiazole is five membered heterocycle having two carbons, two nitrogen, one oxygen and two double bonds. Oxadiazole exists in four isomeric forms depending upon the position of nitrogen atom in the ring. Benzimidazole is a heterocyclic aromatic compound. This bicyclic compound consists of fusion of benzene and imidazole. Benzimidazole may also be considered as cyclic analogues of imidines due to tautomerism effect. In the present study involves synthesis of1,3,4-oxadiazolyl benzenesulphonylbenzimidazole deriv

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8

Mohareb, Rafat, and Hanaa Hana. "Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity." Acta Pharmaceutica 58, no. 1 (2008): 29–42. http://dx.doi.org/10.2478/v10007-007-0043-3.

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Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activityThe aim of this work was to synthesize steroidal heterocycles and to elucidate the potential role of these compounds as antimicrobial agents. The synthesis of steroidal heterocycles containing the pyrazole, isoxazole, thiazole, pyrane, pyridine, pyridazine, or benzopyrane ring attached to the pregnene nucleus is reported. Progesterone (1) reacts with dimethyl formamide dimethyl acetal to form enamine2. Heterocyclization of2with hydrazines, hydroxylamine, glycine, ethyl acetoacetate or cyanomethylene afforded

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9

Deng, Yongming, Qing-Qing Cheng, and Michael Doyle. "Asymmetric [3+3] Cycloaddition for Heterocycle Synthesis." Synlett 28, no. 14 (2017): 1695–706. http://dx.doi.org/10.1055/s-0036-1588453.

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Asymmetric syntheses of six-membered ring heterocycles are important research targets not only in synthetic organic chemistry but also in pharmaceuticals. The [3+3]-cycloaddition methodology is a complementary strategy to [4+2] cycloaddition for the synthesis of heterocyclic compounds. Recent progress in [3+3]-cycloaddition processes provide powerful asymmetric methodologies for the construction of six-membered ring heterocycles with one to three heteroatoms in the ring. In this account, synthetic efforts during the past five years toward the synthesis of enantioenriched six-membered ring hete

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10

Journal, Baghdad Science. "Synthesis of some Heterocyclic Compounds Derived from." Baghdad Science Journal 10, no. 3 (2013): 525–36. http://dx.doi.org/10.21123/bsj.10.3.525-536.

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The 4-(?-bromo acetyl)-4?-toluene sulfonanilide (2) was used as key intermediate to synthesize new heterocyclic compounds. This bromo compound was synthesized via sulfonation of amino group of p-amino acetophenone using Hinsburg method with 4-toluene sulfonyl chloride to form 4-acetyl-4?-toluene sulfonanilide (1) which is used as a starting material in this work. This compound was brominated to yield compound (2) which is used as a precursor to synthesize new five and seven membered heterocyclic compounds such as substituted 1,3-oxazoles (3,4), 1,3-thiazole derivatives (5-7), thiourea compound

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11

Ranskiy, Anatoliy, Natalia Didenko, and Olga Gordienko. "Synthesis of Heterocyclic Thioamides and Copper(II) Coordination Compounds Based on Them." Chemistry & Chemical Technology 11, no. 1 (2017): 11–18. http://dx.doi.org/10.23939/chcht11.01.011.

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12

Huang, Pengfei, Pan Wang, Shengchun Wang, Shan Tang, and Aiwen Lei. "Electrochemical oxidative [4 + 2] annulation of tertiary anilines and alkenes for the synthesis of tetrahydroquinolines." Green Chemistry 20, no. 21 (2018): 4870–74. http://dx.doi.org/10.1039/c8gc02463d.

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13

Zhu, Yannan, and You Huang. "Organocatalyzed [3+3] Annulations for the Construction of Heterocycles." Synthesis 52, no. 08 (2020): 1181–202. http://dx.doi.org/10.1055/s-0039-1690810.

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Six-membered heterocyclic systems are widely distributed in many natural products and pharmaceuticals, and the construction of highly functionalized six-membered heterocyclic compounds is an important topic in modern organic synthesis. Organocatalyzed [3+3] annulations represents an important method for assembling a substantial variety of six-membered cycles that contain one or more heteroatoms. This review describes the development of organocatalyzed [3+3] annulations for the synthesis of six-membered heterocycles, including organocatalysis using secondary amines, tertiary amines, phosphines,

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14

Shaikh, Ansar R., Mazahar Farooqui, R. H. Satpute, and Syed Abed. "Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 424–28. http://dx.doi.org/10.22270/jddt.v8i6-s.2156.

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Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant

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15

Zouaoui, Emna, and Mohamed Moncef El Gaïed. "Synthesis of Trifluoromethyl Heterocyclic Compounds." Journal of Chemical Research 2003, no. 4 (2003): 242–46. http://dx.doi.org/10.1177/1747519803200300404.

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16

Sajida. Munadi. Th.AL-Suraify and Mohammed Abdul-Mounther Othman. "Synthesis and study of spectrally diagnosed heterocyclic compound." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 2613–22. http://dx.doi.org/10.26452/ijrps.v11ispl4.4527.

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In general terms, medicinal chemistry manages the revelation & plan of recent remedial synthetic concoctions & its uses as meds. Throughout the most recent couple of decades, mixes bearing heterocyclic cores have gotten considerably more consideration of the scientific expert, because of their expansive chemo remedial exercises, for example, calming, anthelmintic, hostile to tubercular, against parasitic & hostile to microbial exercises. Furthermore, Heterocycles & medicines are both interred related, the human is totally dependent on drugs & most of the drugs are derived f

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17

Abdullah, Jasim Ali, and Muwafaq Ayesh Rabeaa. "Grinding-Assisted Synthesis of Some Heterocyclic Compounds." Asian Journal of Chemistry 32, no. 7 (2020): 1713–18. http://dx.doi.org/10.14233/ajchem.2020.22268.

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This article involves synthesis of some heterocyclic compounds from an amine derivative using ecofriendly approach (grinding). The first step involves synthesis of Schiff base from benzaldehyde derivatives (3-hydroxybenzaldehyde and 4-nitrobenzaldehyde) with 4-aminoantipyrine. These compounds were used as precursor for the synthesis of heterocyclic compounds and then synthesized tetrazole, oxazepine oxazepane derivatives from Schiff base with sodium azide, phthalic anhydride, maleic anhydride and succinic anhydride, respectively. The heterocyclic compounds were characterized by TLC, melting po

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18

Bassam A. Hassan, Hameedi N Nasera, and Maitham M. Abdulridha. "Synthesis and antimicrobial evaluation of fused heterocyclic compound [1,2,4] triazolo [4,3-b][1,2,4,5] tetra zine." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 1254–58. http://dx.doi.org/10.26452/ijrps.v10i2.417.

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Nitrogen-containing, heterocycles, have special importance and vital, role in the discovery of effective bioactive, agents in the pharmaceutical, industry. The present article reports the synthesis of new fused, heterocycles triazolotetrazine by cyclo condensation, reaction as shown in scheme(1). The structures formula of synthesized compounds newly was evaluated by Ft-IR,1H-NMR spectrum, and C, H, N elemental analysis. Antimicrobial activity of triazolotetrazine studied against some pathogenic bacterial strains isolated from patients like Acinetobacter, Aeromonas, E. coli, Klebsiella, Staphyl

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19

Sharad K. Awate, Suresh V. Patil, Ravindra S. Dhivare, and Renukacharya G. Khanapure. "Microwave-Assisted Synthesis, Characterization and Antimicrobial Potencies of N-Substituted Iminothiazodin-4-One Derivatives." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 589–95. http://dx.doi.org/10.26452/ijrps.v11i1.1861.

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The biggest and most multifaceted class of organic compounds includes heterocyclic compounds. Currently, several heterocyclic compounds are identified, and persistently gratefulness to tremendous synthetic work and synthetic usefulness, the number is increasing exponentially. In most fields of science, including medicinal, pharmaceutical, and agro-chemistry, heterocyclic compounds have a function, and biochemistry is also another area. In this research article, the green approach is administered for achieving the nitrogen, oxygen and sulphur centered five-membered heterocyclic derivatives. By

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20

Manojkumar, Parameswaran, Thengungal Ravi, and Gopalakrishnan Subbuchettiar. "Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells." Acta Pharmaceutica 59, no. 2 (2009): 159–70. http://dx.doi.org/10.2478/v10007-009-0018-7.

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Synthesis of coumarin heterocyclic derivatives with antioxidant activity andin vitrocytotoxic activity against tumour cellsThe aim of the present work was to synthesise coumarinyl heterocycles and to elucidate the potential role of these compounds as antioxidants and cytotoxic agents against Dalton's lymphoma ascites tumour cells (DLA) and Ehrlich ascites carcinoma cells (EAC). The synthesis of coumarin derivatives containing pyrazole, pyrazolone, thiazolidin-4-one, 5-carboxymethyl-4-thiazolidinone and 3-acetyl-1,3,4-oxadiazole ring is reported. 4-Methylcoumarinyl-7-oxyacetic acid hydrazide (1

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21

Harith M. Al-ajely. "Synthesis and pharmaceutical applications of Oxazine compounds derived from Pyronic, Salicylic, Antharanilic acids and Phenols." International Journal of Science and Research Archive 2, no. 2 (2021): 074–86. http://dx.doi.org/10.30574/ijsra.2021.2.2.0250.

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It is well known from FDA reports that More than 75% of the heterocyclic compounds are drugs and 90 of heterocyclic compounds are cancer drugs. The nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. Most drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties, More over heterocyclic compounds are important class of organic chemistry due to their widely spread in nature. Also there are many route for their action and many mechanistic pathways for their preparation and d

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22

Sharma, Praveen Kumar, Andleeb Amin, and M. Kumar. "Synthetic Methods of Medicinally Important Heterocycles-thiazines: A Review." Open Medicinal Chemistry Journal 14, no. 1 (2020): 71–82. http://dx.doi.org/10.2174/1874104502014010071.

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Heterocyclic compounds containing N and S atoms have unique properties so that they can be used as potential reactive materials in pharmacokinetic systems. In medicinal chemistry, the therapeutic applications of nitrogen sulphur heterocycles are well known. Especially, Thiazines attract the attention of chemists due to their great bioactive behavior. The present study is a review of the work carried out by the research community for the synthesis of novel, effective, medicinally important heterocyclic compounds-thiazines.

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23

Gaonkar, Santosh L., Vignesh U. Nagaraj, and Swarnagowri Nayak. "A Review on Current Synthetic Strategies of Oxazines." Mini-Reviews in Organic Chemistry 16, no. 1 (2018): 43–58. http://dx.doi.org/10.2174/1570193x15666180531092843.

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In the past three decades, the heterocyclic oxazine cores have been intensely concerned. Oxazine derivatives are promising vital heterocyclic motifs. They are eminent for their synthetic potential and extensive biological properties. Oxazines are versatile intermediates for the synthesis of a variety of heterocycles and bifunctional compounds. Researchers have reported several synthetic approaches for the preparation of oxazines. This review emphasises the recent approaches for the synthesis of oxazine derivatives.

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24

Al-awar, Rima, and George H. Wahl. "Microscale synthesis of heterocyclic compounds." Journal of Chemical Education 67, no. 3 (1990): 265. http://dx.doi.org/10.1021/ed067p265.

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25

Zouaoui, Emna, and Mohamed Moncef El Gaïed. "Synthesis of trifluoromethyl heterocyclic compounds." Journal of Chemical Research 2003, no. 4 (2003): 242–46. http://dx.doi.org/10.3184/030823403103173651.

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26

Ibrahim, Mohamed N., Mohamed F. El-Messmary, and Mohamed G. A. Elarfi. "Synthesis of Spiro Heterocyclic Compounds." E-Journal of Chemistry 7, no. 1 (2010): 55–58. http://dx.doi.org/10.1155/2010/604549.

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Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives(II), dehydration of(II)gave 3-phenacylidene-2-indolinone derivatives(III). Condensation of(III)with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines(IV & V)and spiropyrimidinethione(VI)respectively. The structures of the final products were established by physical and spectral means.

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27

Cullinane, N. M., and C. G. Davies. "Synthesis of some heterocyclic compounds." Recueil des Travaux Chimiques des Pays-Bas 55, no. 10 (2010): 881–86. http://dx.doi.org/10.1002/recl.19360551009.

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28

Ziarani, Ghodsi Mohammadi, Marzieh Rad, Fatemeh Mohajer, Hitesh Sehrawat, and Ravi Tomar. "Synthesis of Heterocyclic Compounds through Multicomponent Reactions Using 6-Aminouracil as Starting Reagent." Current Organic Chemistry 25, no. 9 (2021): 1070–95. http://dx.doi.org/10.2174/1385272825666210303112858.

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The analogs of 6-Amino uracil are essential components due to their biological activities. The uracil is used as an important component for the synthesis of heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, the application of this compound is reviewed as a precursor in the synthesis of many heterocyclic cores from 2016 to 2020.

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29

Xu, Xinfang, and Michael P. Doyle. "Recent Developments in the Synthetic Uses of Silyl-protected Enoldiazoacetates for Heterocyclic Syntheses." Australian Journal of Chemistry 67, no. 3 (2014): 365. http://dx.doi.org/10.1071/ch13576.

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Diazo compounds have been used as precursors to a wide variety of heterocyclic compounds that represent the core structural subunits in many biologically active compounds. Various methodologies have been established for their synthesis via metal-catalyzed carbene transformations. Although the advantages of vinyldiazoacetates have been known for many years, realization of the synthetic use of enoldiazoacetates has been more recent. This review covers advances in the utility of silyl-protected enoldiazoacetates in heterocycle syntheses that include X–H insertion reactions, ylide rearrangements,

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M, Vijey Aanandhi, Ravichandiran V, and Prem Shankar Misra. "SYNTHETIC ROUTES AND NATURAL SOURCES OF 2-PYRIDONE DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 7 (2017): 87. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.17989.

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Objective: 2-pyridone is a well-known heterocyclic ring having significant biological and medical application. The molecular structures and various activities of 2-pyridone derivatives as well as their syntheses and natural occurrence are analyzed and reviewed, and their reactivity toward various nucleophiles is discussed.Methods: 2-pyridone derivatives, first naturally obtained and described as early as before the 19th century, have been attracting increasing attention in view of their high reactivity as building blocks for the preparation of compounds of various classes due to their selectiv

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31

Slivka, Mikhailo, and Mikhailo Onysko. "The Use of Electrophilic Cyclization for the Preparation of Condensed Heterocycles." Synthesis 53, no. 19 (2021): 3497–512. http://dx.doi.org/10.1055/s-0040-1706036.

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AbstractCondensed heterocycles are well-known for their excellent biological effects and they are undeniably important compounds in organic chemistry. Electrophilic cyclization reactions are widely used for the synthesis of mono-heterocyclic compounds. This review highlights the utility of electrophilic cyclization reactions as an effective generic tool for the synthesis of various condensed heterocycles containing functional groups that are able to undergo further chemical transformations, such as nucleophilic substitution, elimination, re-cyclization, cleavage, etc. This review describes the

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Bąchor, Urszula, та Marcin Mączyński. "Selected β2-, β3- and β2,3-Amino Acid Heterocyclic Derivatives and Their Biological Perspective". Molecules 26, № 2 (2021): 438. http://dx.doi.org/10.3390/molecules26020438.

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Heterocyclic moieties, especially five and six-membered rings containing nitrogen, oxygen or sulfur atoms, are broadly distributed in nature. Among them, synthetic and natural alike are pharmacologically active compounds and have always been at the forefront of attention due to their pharmacological properties. Heterocycles can be divided into different groups based on the presence of characteristic structural motifs. The presence of β-amino acid and heterocyclic core in one compound is very interesting; additionally, it very often plays a vital role in their biological activity. Usually, such

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33

Loughlin, Wendy A. "Invited Review. Combinatorial Synthesis: A Heterocyclic Chemist's Perspective." Australian Journal of Chemistry 51, no. 10 (1998): 875. http://dx.doi.org/10.1071/c98066.

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An overview of the combinatorial synthesis of heterocyclic compounds is presented. Recent developments and innovations in the solid and solution phase combinatorial synthesis of heterocyclic compounds are discussed.

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Parveen, Mehtab, Afroz Aslam, Shahab A. A. Nami, and Musheer Ahmad. "Z-Acrylonitrile Derivatives: Improved Synthesis, X-ray Structure, and Interaction with Human Serum Albumin." Current Organic Synthesis 16, no. 8 (2020): 1149–60. http://dx.doi.org/10.2174/1570179416666191008085806.

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Aim and Objective: In the synthesis of heterocyclic compounds, acrylonitrile derivatives are the most important and appropriate precursors. These compounds are the most important intermediates and subunits for the enhancement of molecules having pharmaceutical or biological interests. Nitrogen-containing compounds have received extensive consideration in the literature over the years. Materials and Methods: A facile, economic and efficient method has been developed for the synthesis of acrylonitrile derivatives using p-nitrophenylacetonitrile and aromatic/heterocyclic aldehydes in the presence

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35

Haji, Mohammad. "Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates." Beilstein Journal of Organic Chemistry 12 (June 21, 2016): 1269–301. http://dx.doi.org/10.3762/bjoc.12.121.

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Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic compounds bearing a phosphonate group on the ring is given.

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36

Cano, Jessica R. Gutiérrez, Julio López, Miguel A. Vázquez, David Cruz Cruz, and Clarisa Villegas Gómez. "Trienamines for the Organocatalytic Synthesis of Nitrogen-Containing Heterocycles." Current Organic Chemistry 23, no. 10 (2019): 1078–89. http://dx.doi.org/10.2174/1385272823666190617164651.

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Nitrogen-containing heterocycles (NCH), constitute an important group of molecules, which are widely extended in whole chemical space. These compounds are of great interest due to their diverse biological activities. Currently, many compounds derived from NCH are used as powerful drugs for the treatment of diseases ranging from bactericides to anticancer agents. During last decade, the enantioselective synthesis of numerous heterocyclic compounds has been achieved through the use of chiral organocatalysts. The present contribution explores the application of the aminocatalysis towards the synt

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Philkhana, Satish Chandra, Fatimat O. Badmus, Isaac C. Dos Reis, and Rendy Kartika. "Recent Advancements in Pyrrole Synthesis." Synthesis 53, no. 09 (2021): 1531–55. http://dx.doi.org/10.1055/s-0040-1706713.

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AbstractThis review article features selected examples on the synthesis of functionalized pyrroles that were reported between 2014 and 2019. Pyrrole is an important nitrogen-containing aromatic heterocycle that can be found in numerous compounds of biological and material significance. Given its vast importance, pyrrole continues to be an attractive target for the development of new synthetic reactions. The contents of this article are organized by the starting materials, which can be broadly classified into four different types: substrates bearing π-systems, substrates bearing carbonyl and ot

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38

BALUJA, S., D. MENPARA, S. CHANDA, and K. NANDHA. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW PYRAZOLO QUINAZOLINE DERIVATIVES." Latin American Applied Research - An international journal 45, no. 3 (2015): 157–63. http://dx.doi.org/10.52292/j.laar.2015.391.

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Pyrazolo[5,1-b]quinazolines are known to be versatile heterocyclic compounds with different biological properties because of a large number of derivatives with different structural modifications. Therefore, some new Pyrazolo quinazoline heterocycles were synthesized from chalcones and their structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectral data. All these synthesized compounds were tested in vitro for their antimicrobial potential against Gram positive, Gram negative strains of bacteria as well as fungal strains in dimethylsulfoxide. Among the screened compounds, KC-10 showed

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Giubellina, Nicola, Wim Aelterman, and Norbert De Kimpe. "Use of 3-halo-1-azaallylic anions in heterocyclic chemistry." Pure and Applied Chemistry 75, no. 10 (2003): 1433–42. http://dx.doi.org/10.1351/pac200375101433.

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The synthetic potential of lithio 3-halo-1-azaallylic anions as building blocks in organic chemistry and especially in heterocyclic chemistry will be highlighted by the synthesis of functionalized imines, obtained after reaction of 3-halo-1-azaallylic anions with het- eroatom-substituted electrophiles. Thus, the latter generated functionalized imines are suitable building blocks for the synthesis of a whole range of heterocycles and physiologically active compounds, including agrochemicals and pharmaceuticals. 3-Halo-1-azaallylic anions were used in the synthesis of N-alkyl-3,3-dichloroazetidi

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Atalla, Ahmed A., Adel M. Kamal El-Dean, and Abd El-Fattah A. Harb. "Synthesis of some new heterocyclic compounds containing chromene." Collection of Czechoslovak Chemical Communications 56, no. 4 (1991): 916–22. http://dx.doi.org/10.1135/cccc19910916.

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2-amino-3-cyano-4H-phenyl-benzo[f]chromene (I) was reacted with formamide, acetic anhydride, and ethyl cyanoacetate to produce compounds (II-IV), respectively. Compound IV reacted with HCONH2, POCl3 and P2S5 to produce corresponding pyrimidobenzochromene (V), chloropyridobenzochromene (VI) and mercaptopyridobenzochromene (VII). Compound VII reacted with α-halocompounds to produce corresponding S-alkylated derivatives (VIIIa to VIIIc), and compound (VI) reacted with different amines to produce corresponding alkyl amino-, or aryl aminopyridobenzochromene (IXa-IXc) but in using hydrazine hydrate,

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Sbei, Najoua, Anna V. Listratova, Alexander A. Titov, and Leonid G. Voskressensky. "Recent Advances in Electrochemistry for the Synthesis of N-Heterocycles." Synthesis 51, no. 12 (2019): 2455–73. http://dx.doi.org/10.1055/s-0037-1611797.

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The construction of N-heterocyclic rings represents a very important and fast-developing area of organic synthesis. In this context, electrochemistry has emerged as a mild solution for generating in situ the required electrophilic substrates, bases and nucleophiles derived from low-level and extremely stable reagents, the further application of which makes some heterocycles more accessible. In this review, we have covered the recent advances in the electrochemical synthesis of five- and six-membered N-heterocyclic compounds published from 2017 to October 2018.1 Introduction2 Electrochemical Sy

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Hawaiz, Farouq E., Mohammed K. Samad, and Marlin Y. Aziz. "Synthesis of some new heterocyclic compounds derived from 4-(4-hydroxy-3-chlorophenyl) azoaceto phenone." Journal of Zankoy Sulaimani - Part A 17, no. 2 (2015): 85–92. http://dx.doi.org/10.17656/jzs.10383.

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Kottakki, Naveen K., and Amperayani K. Rao. "SYNTHESIS OF PIPERINE - PIPERAZINE ANALOGUES AND THEIR ANTIBACTERIAL ACTIVITY." INDIAN DRUGS 58, no. 06 (2021): 30–35. http://dx.doi.org/10.53879/id.58.06.12311.

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In the current study, a series of piperine – piperazine analogues (5a to 5f) were designed and synthesized. The piperine was isolated from pepper and used for the conjugation with heterocyclic moiety for better biological activity. The piperazine heterocyclic was chosen for conjugation with piperine. The newly synthesized structures were determined by IR, 1H NMR and 13C NMR spectral data. The compounds were examined for their anti‐microbial activity against gram-positive (Bacillus subtilis) and gram-negative (Vibrio cholerae) bacteria using the agar well diffusion method. The newly synthesized

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KONDO, Yoshinori, Hisashi SHINKAI, and Ken-ichi TANJI. "Solid Phase Synthesis of Heterocyclic Compounds." Journal of Synthetic Organic Chemistry, Japan 56, no. 1 (1998): 2–10. http://dx.doi.org/10.5059/yukigoseikyokaishi.56.2.

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Ziarani, Ghodsi Mohammadi, Negar Lashgari, Fereshteh Azimian, Hendrik G. Kruger, and Parisa Gholamzadeh. "Ninhydrin in synthesis of heterocyclic compounds." Arkivoc 2015, no. 6 (2015): 1–139. http://dx.doi.org/10.3998/ark.5550190.p008.905.

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Zhang, Bianxiang, Yongqiang Kang, and Ruixue Shi. "Synthesis of Aromatic Heterocyclic Sulfide Compounds." Chinese Journal of Organic Chemistry 36, no. 8 (2016): 1814. http://dx.doi.org/10.6023/cjoc201602021.

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Eftekhari-Sis, Bagher, Maryam Zirak, and Ali Akbari. "Arylglyoxals in Synthesis of Heterocyclic Compounds." Chemical Reviews 113, no. 5 (2013): 2958–3043. http://dx.doi.org/10.1021/cr300176g.

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Azev, Yuri, Irina Slepukhina, and Detlef Gabel. "Synthesis of boron-containing heterocyclic compounds." Applied Radiation and Isotopes 61, no. 5 (2004): 1107–10. http://dx.doi.org/10.1016/j.apradiso.2004.05.002.

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Venkatachalam, T. K., and F. M. Uckun. "Synthesis of Substituted Heterocyclic Thiourea Compounds." Synthetic Communications 37, no. 20 (2007): 3667–75. http://dx.doi.org/10.1080/00397910601163604.

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Fürmeier, Sandra, and Jürgen O. Metzger. "Synthesis of New Heterocyclic Fatty Compounds." European Journal of Organic Chemistry 2003, no. 5 (2003): 885–93. http://dx.doi.org/10.1002/ejoc.200390134.

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