Relevant bibliographies by topics / Synthesis of fused sulfonamide

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Academic literature on the topic 'Synthesis of fused sulfonamide'

Author: Grafiati
Published: 5 June 2025
Last updated: 8 July 2025

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Journal articles on the topic "Synthesis of fused sulfonamide"

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Beduru, Srinivas, and Andrei G. Kutateladze. "Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides." Molecules 28, no. 18 (2023): 6549. http://dx.doi.org/10.3390/molecules28186549.

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Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex polyheterocycles. In our prior work we have employed ESIPT in aromatic o-keto amines and amides, leading to diverse primary photoproducts—complex quinolinols or azacanes possessing a fused lactam moiety—which could additionally be modified in short, high-yielding postphotochemical reactions to further grow complexity of the heterocyclic core scaffold and/or to decorate it with additional functional groups. Given that sulfonamides are generally known as privileged substructures, in this study we pursued two goals: (i) To explore whether sulfonamides could behave as proton donors in the context of ESIPT-initiated photoinduced reactions; (ii) To assess the scope of subsequent complexity-building photochemical and postphotochemical steps, which give access to polyheterocyclic molecular cores with fused cyclic sulfonamide moieties. In this work we show that this is indeed the case. Simple sulfonamide-containing photoprecursors produced the sought-after heterocyclic products in experimentally simple photochemical reactions accompanied by significant step-normalized complexity increases as corroborated by the Böttcher complexity scores.
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Laha, Joydev K., Rohan A. Bhimpuria, and Aitha Manoj Kumar. "Post-synthetic diversification of pyrrole-fused benzosultams via trans-sulfonylations and reactions on the periphery of pyrrole." Organic Chemistry Frontiers 4, no. 11 (2017): 2170–74. http://dx.doi.org/10.1039/c7qo00440k.

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The synthesis of pyrrole fused benzosultams and their trans-sulfonylation reactions providing workable access to (NH)-2-arylpyrroles containing ortho-sulfonamide functionality and fluorene tethered pyrrole fused benzosultam has been described.
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Manojit, Pal, Rao Veeramaneni Venugopal, Kumar Sanjeev, B. Lohray Vidya, and Rao Yeleswarapu Koteswar. "Synthesis of fused sulfonamide (1,1-dioxoisothiazole)substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors." Journal of Indian Chemical Society Vol. 80, Dec 2003 (2003): 1095–101. https://doi.org/10.5281/zenodo.5839785.

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Chemistry, Discovery Research, Dr. Reddy&#39;s Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad-500 049, India E-mail : manojitpal @drreddys.com; koteswarraoy @drreddys.com&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Fax : 91-40-23045438/23045007 <em>Manuscript received 15 October 2003</em> First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[<em>d</em>]isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-nuoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3- dicarbonyl compounds. A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biological interest.
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Arshad, Nasima, Yasir Mehmood, Hammad Ismail, et al. "Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses." RSC Advances 14, no. 47 (2024): 35047–63. http://dx.doi.org/10.1039/d4ra06412g.

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This work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4-d]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-d)isoxazole-based fused ring heterocyclic system.
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Donthukurthi, Saisuryanarayana, Devdatt J. Patel, Rakesh I. Patel, and Piyush J. Vyas. "Synthesis, Characterization and Antimicrobial Activity of Thiazolo-oxazine Fused Heterocyclic Derivatives, Based on Benzene Sulfonyl Hydrazide." Oriental Journal Of Chemistry 39, no. 3 (2023): 721–26. http://dx.doi.org/10.13005/ojc/390323.

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Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. (1a-e) SBSZ were then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) were then condensed with 5-nitro-2furfuralidine derivatives i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These derivatives were further condensed with phenyl urea to yield fused heterocyclic derivatives i.e. N-(2-substituted-7-(5-nitrofuran-2-yl)-5-(phenylamino)-2H-thiazolo[5,4-e] [1,3]oxazin-3(3aH)-yl) benzene sulfonamide (4a-e). All the derivatives were characterised by C, H, N elemental analyser and IR-NMR-Mass Spectra. The antimicrobial properties of all the derivatives were studied for selected common microbes. The results of antibacterial activity of all three series (i.e. 2a-e, 3a-e, and 4a-e) of compounds indicate that all compounds are toxic for bacteria. However, the chlorine containing compounds are more toxic than others.
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Ito, Hideto, Tomoya Harada, Hirohisa Ohmiya, and Masaya Sawamura. "Intramolecular hydroamination of alkynic sulfonamides catalyzed by a gold–triethynylphosphine complex: Construction of azepine frameworks by 7-exo-dig cyclization." Beilstein Journal of Organic Chemistry 7 (July 8, 2011): 951–59. http://dx.doi.org/10.3762/bjoc.7.106.

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The gold-catalyzed, seven-membered ring forming, intramolecular hydroamination of alkynic sulfonamides has been investigated. The protocol, with a semihollow-shaped triethynylphosphine as a ligand for gold, allowed the synthesis of a variety of azepine derivatives, which are difficult to access by other methods. Both alkynic sulfoamides with a flexible linear chain and the benzene-fused substrates underwent 7-exo-dig cyclization to afford the nitrogen-containing heterocyclic seven-membered rings, such as tetrahydroazepine and dihydrobenzazepine, in good yields.
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S, Priyanka. "Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles." Der Pharma Chemica 14, no. 1 (2022): 2. https://doi.org/10.5281/zenodo.13353756.

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Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in these natural compounds derives from the aromatic amino acid tyrosine.
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Said, Mohamed A., Wagdy M. Eldehna, Alessio Nocentini, et al. "Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation." European Journal of Medicinal Chemistry 189 (March 2020): 112019. http://dx.doi.org/10.1016/j.ejmech.2019.112019.

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Sedenkova, Kseniya N., Kristian S. Andriasov, Marina G. Eremenko, et al. "Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity." Molecules 27, no. 11 (2022): 3546. http://dx.doi.org/10.3390/molecules27113546.

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The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance. Among the works of the last decade, a literature search revealed spirothiazamenthane, which has served as a lead in the development of derivatives active against resistant viral strains. In this work, we studied the novel molecular scaffold, which resembles spirothiazamenthane, but combines isoxazoline as a heterocycle and cyclooctane ring as a hydrophobic part of the structure. The synthesis of new 3-nitro- and 3-aminoisoxazolines containing spiro-fused or 1,2-annelated cyclooctane fragments was achieved by employing 1,3-dipolar cycloaddition of 3-nitro-4,5-dihydroisoxazol-4-ol 2-oxide or tetranitromethane-derived alkyl nitronates with non-activated alkenes. A series of spiro-sulfonamides was obtained by the reaction of 3-aminoisoxazoline containing a spiro-fused cyclooctane residue with sulfonyl chlorides. Preliminary screening of the compounds for antiviral, antibacterial, antifungal and antiproliferative properties in vitro revealed 1-oxa-2-azaspiro[4.7]dodec-2-en-3-amine and 3a,4,5,6,7,8,9,9a-octahydrocycloocta[d]isoxazol-3-amine with activity against the influenza A/Puerto Rico/8/34 (H1N1) virus in the submicromolar range, and high values of selectivity index. Further study of the mechanism of the antiviral action of these compounds, and the synthesis of their analogues, is likely to identify new agents against resistant viral strains.
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Sanad, Sherif M. H., and Ahmed E. M. Mekky. "New pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors." Canadian Journal of Chemistry 99, no. 11 (2021): 900–909. http://dx.doi.org/10.1139/cjc-2021-0121.

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In the current study, we reported the tandem synthesis of two series of arene-linked pyrimidinone hybrids with related fused thieno[2,3-b]pyridine moiety. The target hybrids were prepared, in moderate to excellent yields, by the reaction of a ternary mixture of the appropriate of 3-aminothieno[2,3-b]pyridine-2-carboxylate, DMF-DMA, and a series of aryl amines in dioxane at 110 °C for 8 h. The antibacterial activity of the new hybrids was estimated against six susceptible ATCC strains. Hybrids 5g and 7g, linked to a sulfonamide unit, showed the best efficacy against S. aureus and E. faecalis strains with minimum inhibitory concentration (MIC) values of 1.7–1.8 μM, which exceed ciprofloxacin. Furthermore, some of new hybrids were examined as potential inhibitors of four different MRSA and VRE strains. Hybrids 5g and 7g demonstrated more potent efficacy than linezolid against MRSA strains with MIC values of 3.6/3.4 and 1.8/1.7 μM against ATCC:33591 and ATCC:43300 strains, respectively. The prior hybrids displayed a comparable efficacy with linezolid against VRE strains with MIC values of 7.3/6.9 and 3.6/3.4 μM against ATCC:51299 and ATCC:51575 strains, respectively. Additionally, some of the new hybrids were examined as potential COX-2 inhibitors using the reference celecoxib (IC50 of 0.117 µM). Hybrid 7g revealed more potent inhibitory efficacy than celecoxib with IC50 of 0.112 µM, whereas hybrid 5g showed almost inhibitory activity equivalent to celecoxib with IC50 of 0.121 µM. Molecular docking was performed to predict the possible binding interactions between hybrids 5g and 7g with the target COX-2 enzyme.
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Dissertations / Theses on the topic "Synthesis of fused sulfonamide"

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Silva, Raquel Sofia de Oliveira Nunes da. "Phthalocyanine-sulfonamide conjugates-synthesis and biological activity." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22842.

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Doutoramento em Química<br>O uso inapropriado de antibióticos no tratamento de doenças infeciosas tem levado a um aumento da resistência de diversos microrganismos patogénicos, o que apresenta atualmente um problema de saúde pública e tem motivado a procura de estratégias alternativas para o controlo destes microrganismos. Por outro lado, a procura de novas moléculas ou novas combinações de moléculas para o combate ao cancro é um assunto em constante desenvolvimento. Na presente dissertação descreve-se o trabalho desenvolvido para a obtenção de conjugados de ftalocianina–sulfonamida e a avaliação da atividade dos novos compostos como fotossensibilizadores. Os conjugados foram idealizados com o intuito de promover um possível efeito sinérgico das suas unidades constituintes, nomeadamente propriedades antitumorais e/ou antimicrobianas. Para tal, desenvolveram-se métodos de síntese de sulfonamidas e de conjugados de ftalocianina–sulfonamida. Algumas das ftalocianinas obtidas foram testadas como fotossensibilizadores na eliminação fotodinâmica de células tumorais e de bactérias, utilizando-se as linhas celulares de carcinoma de células escamosas orais (HSC3) e de queratinócitos orais (HaCaT), e as bactérias Escherichia coli (Gram-negativo) Staphylococcus aureus (Gram-positivo) como modelos biológicos. Os resultados destes estudos revelaram que as ftalocianinas estudadas são muito promissoras como fotossensibilizadores para a inativação fotodinâmica de células tumorais e de microrganismos. Por outro lado, foi também desenvolvido um ensaio enzimático para avaliar a atividade dos novos compostos como inativadores da enzima anidrase carbónica, em particular a isoforma IX que se encontra sobre-expressa em células tumorais e é bem conhecida como reguladora do pH em processos de hipoxia e acidose metabólica. Este estudo vem dar mais um passo no conhecimento científico das ftalocianinas e evidencia o potencial das ftalocianinas sulfonadas na perspetiva do controlo de infeções e da tumorogénese.<br>The inappropriate use of antibiotics in the treatment of infections has led to an increase in the resistance of several pathogenic microorganisms, which represents a major public health issue and triggered the search for novel antimicrobial drugs. On the other hand, the search for new molecules or new combinations of molecules for the fight against cancer is a subject in constant development. The present dissertation describes the work developed to obtain phthalocyanine–sulfonamide conjugates and the biological evaluation of these compounds as photosensitizers. These conjugates were designed to explore their antimicrobial and/or antitumor properties. Methods for the synthesis of sulfonamides and phthalocyanine–sulfonamide conjugates were developed. Some of the phthalocyanines obtained were tested as photosensitizers for the photodynamic inactivation of tumor cells and bacteria. HSC3 oral squamous cell carcinoma, HaCaT 'normal' keratinocytes, and the bacteria Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) were used as biological models. The phthalocyanines studied proved to be very promising to be considered in future studies in the perspective of the photodynamic inactivation of tumor cells and microorganisms. On the other hand, an enzymatic assay was also developed to evaluate the activity of the compounds obtained as inactivators of the enzyme carbonic anhydrase, in particular the IX isoform that is overexpressed in tumor cells and is well-known as pH regulator in processes of hypoxia and metabolic acidosis. This study represents a contribution to the application of phthalocyanines, and in particular sulfonated phthalocyanines, in the control of infections and tumorigenesis.
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Hall, Brady. "Synthesis, Characterization, and Polymerization of Sulfonamide Based Bifunctional Monomers." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1471349342.

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Garcia, Cristina. "Synthesis of ring fused 2-pyridones." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102704.

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Kiss, Emily. "Diasterodivergent synthesis of fused ring systems." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:37545702-38f9-4bb5-a233-69a296387792.

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Introduction: We envisioned using phase transfer catalysis (PTC) to develop asymmetric carba-6p- electrocyclisations. We believed that the configurational lability of 6p systems could be reduced by constraining them within a ring system. Results and Discussion: En route to the synthesis of a starting material for the transannular electrocyclisation reaction, we noticed that a 5-5-3 fused ring system had formed, in one step, from a linear precursor and as a single diastereomer. We synthesised both geometric isomers of the starting materials, and unexpectedly, the E or Z isomers cyclised to form different products under different reaction conditions. We further investigated the 5-5-3 system, generating substrate scope and computationally and experimentally exploring the mechanism. Conclusion: In one step we have constructed three carbon-carbon bonds, up to five contiguous stereogenic centres and all as a single diastereomer. We have synthesised 15 examples and have probed the mechanism experimentally and computationally. We have also investigated asymmetric examples of this reaction.
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Hubbard, Jeremiah W. "Novel synthesis of 3,4-fused indoles." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2209.

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Thesis (M.S.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xi, 70, 76 p. : ill. Includes abstract. Includes bibliographical references (p. 67-70).
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Cartwright, Matthew William. "Highly functionalised fused heterocycle synthesis from fluoropyridines." Thesis, Durham University, 2006. http://etheses.dur.ac.uk/2622/.

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Current approaches to drug discovery tends to involve the rapid analogue synthesis and testing of small, focused libraries of low molecular weight, structurally similar "drug-like" molecules, often based around heterocyclic core scaffolds. If some desired activity is shown by a compound, elaboration can give higher activity and more favourable pharmiokinetic properties. As this "lead generation" stage of drug development has been identified as a major bottleneck in the drug pipeline process, there is a great demand for methodology detailing the synthesis of highly functionalised heterocyclic compounds. Our approach involves the sequential nucleophilic aromatic substitution of highly fluorinated pyridines, in an efficient and flexible manner, to furnish a range of novel, functionalised polycyclic systems.
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Rodger, Robert. "Fused ring systems in natural product synthesis." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27645.

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On the instigation of A/Prof C. S. P. McErlean I investigated the rapid synthesis of fused ring compounds by a key polyene cyclisation. Chapter 1 sets the scene by highlighting deficiencies in literature syntheses of selected fused-ring compounds, where synthetic strategies are often suboptimal. In particular, the scarcity of reported syntheses involving a direct cyclisation method is noted. Chapter 2 discusses the taiwaniaquinoids and previous synthetic approaches including McErlean group efforts which delivered the non-natural stereochemistry. A method to produce the desired trans stereochemistry of ()-taiwaniaquinone G was developed. Attempts to apply this methodology to a divergent synthesis of the taiwaniaquinoids are detailed. Chapter 3 extends this strategy to the attempted synthesis of compounds with a greater number of rings: the dasyscyphins, pelorol, atomarianone B and disidein. The successful partial cyclisation and subsequent full cyclisation of two farnesylarenes was reported. Larger architectures remain an elusive goal. Chapter 4 discusses efforts in the synthesis of a different class of fused-ring compounds: the marine polycyclic ethers. The application of newer methodologies to the synthesis of the polycyclic ethers is described, however this did not lead to a viable strategy to these compounds.
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Allwein, Shawn Paul. "Iterative strategies toward the synthesis of fused ether ring systems and the synthesis of fused ether containing natural products." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/280230.

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A highly efficient and general approach to fused ether ring systems has been presented. The approach couples stereoselective C-glycoside forming reactions with subsequent annulations. C-glycosides were formed from glycals through an oxidation and carbon-carbon bond forming sequence. Annulations involving a two step methylenation/enol ether-olefin ring closing metathesis or a single flask, acid mediated cyclization/elimination proved to be efficient tribenzyl- D-glucal (95), [4.4.0] and [4.5.0] bicyclic enol ethers (194, 200, 204) were stereoselectively generated in 2-4 steps in good overall yields (53%, 57%, and 39% respectively). Iteration resulted in the stereoselective formation of tricylic enol ethers (240, 241). In addition, our C-glycoside approach was applied to the synthesis of fused ether containing natural products. A formal synthesis of (±)-hemibrevetoxin B (2) was achieved by intercepting Mori's intermediate ( 278) in 21 steps and 3.8% overall yield. The C-glycoside approach to fused ethers was also demonstrated in the synthesis of halichondrin B's model compounds, bicycle 374 and tricycle 383. Subsequent fragmentation of 383 resulted in bicyclic alcohol 384 which correlates to the C,23-C,38 subunit of halichondrin B (8).
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Steele, Rory G. "Synthesis of fused cyclic ethers : towards the synthesis of hemibrevetoxin B." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363594.

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Flores, Jose Luis Castrejon. "The chemical synthesis of sulfonamide metabolites and their role in drug hypersensitivity." Thesis, University of Liverpool, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511083.

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Books on the topic "Synthesis of fused sulfonamide"

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Ellis, G. P. Synthesis of fused heterocycles. Wiley, 1987.

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Ellis, G. P. Synthesis of fused heterocycles. Wiley, 1987.

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Ellis, G. P. Synthesis of fused heterocycles : Part 2. Wiley, 1992.

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Ito, Tomohiro. Synthesis of Medium-Sized Cycloalkenes via Fused-Cyclobutenes. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-0787-4.

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Hayes, Roy. The synthesis of 5,6,7- and 7,7-fused azepine systems. University of Salford, 1987.

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Matsumoto, Arimasa. Iron-Catalyzed Synthesis of Fused Aromatic Compounds via C–H Bond Activation. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54928-4.

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Lednicer, Daniel. The organic chemistry of drug synthesis. Wiley, 1995.

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Lednicer, Daniel. The organic chemistry of drug synthesis. Wiley, 1990.

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Ellis, Gwynn P. Synthesis of Fused Heterocycles. Wiley & Sons, Incorporated, John, 2009.

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Ellis, Gwynn P. Synthesis of Fused Heterocycles, Part 2. Wiley & Sons, Incorporated, John, 2009.

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Book chapters on the topic "Synthesis of fused sulfonamide"

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Kaur, Navjeet. "Five-Membered Fused N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-3.

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Kaur, Navjeet. "Six-Membered Fused N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-9.

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Odagi, Minami, and Kazuo Nagasawa. "Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids." In Modern Natural Product Synthesis. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_10.

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AbstractThe synthesis of alkaloids featuring fused polycyclic frameworks has long attracted the interest of synthetic organic communities, owing to their great structural complexity and wide variety of biological activities. Indeed, a variety of strategies for synthesizing these alkaloids have been investigated over the years. Here, we present our innovative strategy for tahe construction of complex fused polycyclic frameworks via oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction. We illustrate its practical application in synthetic studies of amaryllidaceae alkaloids, and hasubanan alkaloids.
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Kaur, Navjeet. "Five-Membered Poly and Fused O-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-5.

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Ono, Noboru. "New Conducting Polypyrroles Fused with Aromatic Rings." In Novel Trends in Electroorganic Synthesis. Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-65924-2_43.

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Settambolo, Roberta. "Rhodium-Catalyzed Hydroformylation in Fused Azapolycycles Synthesis." In Topics in Current Chemistry. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/128_2013_432.

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Uno, Hidemitsu, Kazunari Tagawa, Hajime Watanabe та ін. "Synthesis of a Porphyrin-Fused π-Electron System". У Chemical Science of π-Electron Systems. Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55357-1_2.

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Mashiko, Tomoya, Yuta Shingai, Jun Sakai, et al. "Enantioselective Total Syntheses of (−)-Cochlearol B and (+)-Ganocin A." In Modern Natural Product Synthesis. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-1619-7_16.

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AbstractHerein, we describe the first total synthesis of (±)-cochlearol B and the enantioselective total syntheses of (−)-cochlearol and (+)-ganocin A. The key steps include Corey-Bakshi-Shibata reduction, oxidative phenolic cyclization, intramolecular [2+2] photocycloaddition, and intramolecular radical cyclization-benzylic oxidative cyclization, enabling efficient access to 4/5/6/6/6 and 5/5/6/6/6-fused pentacyclic frameworks of these natural products.
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Taber, Douglass F. "Alkaloid Synthesis: Lycoposerramine Z (Bonjoch), Esermethole (Shishido), Goniomitine (Zhu), Grandisine (Taylor), Reserpine (Jacobsen)." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0061.

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Josep Bonjoch of the Universitat de Barcelona extended (Org. Lett. 2013, 15, 326) the Jørgensen variation of the Robinson annulation to the amine-substituted β-keto ester 1. The product cis-fused sulfonamide 3, readily brought to high ee by recrystallization, was carried onto (+)-lycoposerramine Z 4. Intramolecular ketene 2+2 cycloaddition is underdeveloped as a synthetic method. Kozo Shishido of the University of Tokushima observed (Org. Lett. 2013, 15, 200) high diastereoselectivity in the cyclization of 5 to 6. This set the stage for the synthesis of (-)-esermethole 7. Jieping Zhu of the Ecole Polytechnique Fédérale de Lausanne prepared (Angew. Chem. Int. Ed. 2013, 52, 3272) the cyclopentene 8 by coupling the alkenyl triflate with the salt of an α-alkyl arylacetic acid. Ozonolysis followed by reductive work-up led to a diamino keto aldehyde that cyclized to 9. Benzyl ether cleavage delivered (±)-goniomitine 10. Richard J.K. Taylor of the University of York developed (Angew. Chem. Int. Ed. 2013, 52, 1490) a powerful tandem conjugate addition-imination-methanolysis protocol. He had already prepared (+)-grandisine 11 from N-Boc prolinol. Amination-imination converted 11 to (+)-grandisine 12. This was opened by methanolysis to (+)-grandisine G 13. Four diastereomers are possible from the condensation of 14 and 15. Eric N. Jacobsen of Harvard University developed (Org. Lett. 2013, 15, 706) an organocatalyst that delivered 16 as the dominant diastereomer. This was readily converted to (+)-reserpine, the enantiomer of the natural product.
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Gallagher, P. T. "Intramolecular Displacement of Bromine with a Sulfonamide." In Fused Five-Membered Hetarenes with One Heteroatom. Georg Thieme Verlag KG, 2001. http://dx.doi.org/10.1055/sos-sd-010-00904.

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Conference papers on the topic "Synthesis of fused sulfonamide"

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Lu, Haipeng, Nan Xie, Zhengxu Li, Wei Pang, and Yongming Zhang. "EngaGes: An Engagement Fused Co-Speech Gesture Synthesis Model." In 2024 11th International Forum on Electrical Engineering and Automation (IFEEA). IEEE, 2024. https://doi.org/10.1109/ifeea64237.2024.10878669.

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Muškinja, Jovana M., Jelena S. Katanić Stanković, and Zoran R. Ratković. "SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.351m.

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Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compounds were tested for their antioxidant activities using two different methods, DPPH radical and ABTS radical cation scavenging assays. The results showed relatively good in vitro antioxidant activity.
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Jin, Lei, Chuangye Ge, Sujin Yoon, et al. "Synthesis partially sulfonamide hydrocarbon membranes for PEMFC." In 2020 11th International Renewable Energy Congress (IREC). IEEE, 2020. http://dx.doi.org/10.1109/irec48820.2020.9310398.

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Petukhov, D., S. Pestova, and E. Izmest’ev. "SYNTHESIS OF SULFONAMIDE DEHYDROABIETANE DERIVATIVES OF AMINO ACIDS." In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-452.

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Diaconu, Dumitrela, Violeta Mangalagiu, Dorina Amariucai-Mantu, Vasilichia Antoci, and Ionel Mangalagiu. "SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.45.

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Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combination we have decided to combine the two pharmacophore fragments. And at last, the complexation with divalent metals - M2+ (M2+: Zn2+, Cu2+, Co2+ and Cd2+) will bring complementary biological activity given by the cation with the final goal of achieving improved biological activity and better pharmacokinetic properties. The synthesized molecules were characterized by HRMS and NMR spectroscopy. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising.v
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Al-Azzawi, Ahlam M., and Mustafa D. Huseeni. "Synthesis and antioxidant activity study of poly (imede-sulfonamide)s." In INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING ICCMSE 2021. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0116518.

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Niu, Enli, Qiang Gan, Xi Chen, and Changgen Feng. "Sulfonamide-containing PTP 1B inhibitors: Docking studies, synthesis and model validation." In MATHEMATICAL SCIENCES AND ITS APPLICATIONS. Author(s), 2017. http://dx.doi.org/10.1063/1.4971949.

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Muškinja, Jovana, Zoran Ratković, Suzana Popović, Sanja Matić, Danijela Todorović, and Dejan Baskić. "Dehydrozingerone analogues in synthesis attractive sulfonamide compounds as potential antitumor agents." In The 23rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecsoc-23-06600.

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Mangalagiu, Violeta, Dumitrela Diaconu, and Ionel Mangalagiu. "Quinoline - sulfonamide - complexes with antimicrobial activity." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab26.

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Quinoline-sulfonamide-complexes with variously metals, especially M2+, are a relatively new class of compounds with potential practical interest as fluorescent materials (having fotoluminiscent properties) and also as drugs (having a large variety of biological activities such as antibacterial, antifungal, antiprotozoals, etc.). The emphasis of this work was to obtain hybrid quinoline – sulfonamide - complexes with antimicrobial activity. The synthesis of the hybrid derivatives is direct and efficient, in two steps: acylation of variously amino-quinoline followed by metal complexation with different metals M2+ (Zn2+, Cu2+, Co2+, Cd2+, Ni2+, Pd2+). Following this experimental setup several series of synthetic hybrid quinoline – sulfonamide - complexes was obtained. The hybrid complexes were characterized by IR and NMR spectroscopy, elemental analysis and X-ray diffraction on single crystal. The antibacterial and antifungal activity was determined against gram positive bacteria Staphylococcus aureus ATCC25923, gram negative bacteria Escherichia coli ATCC25922 and fungus Candida albicans ATCC10231. The obtained data from the antimicrobial assay reveal that some of the obtained hybrids have a very good antimicrobial and antifungal activity.
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Zhu, Mingtong, Xiangning Liu, and Ronggang Wang. "Fused Network for View Synthesis." In 2020 IEEE Conference on Multimedia Information Processing and Retrieval (MIPR). IEEE, 2020. http://dx.doi.org/10.1109/mipr49039.2020.00069.

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Reports on the topic "Synthesis of fused sulfonamide"

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Grafi, Gideon, and Brian Larkins. Endoreduplication in Maize Endosperm: An Approach for Increasing Crop Productivity. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575285.bard.

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The focus of this research project is to investigate the role of endoreduplication in maize endosperm development and the extent to which this process contributes to high levels of starch and storage protein synthesis. Although endoreduplication has been widely observed in many cells and tissues, especially those with high levels of metabolic activity, the molecular mechanisms through which the cell cycle is altered to produce consecutive cycles of S-phase without an intervening M-phase are unknown. Our previous research has shown that changes in the expression of several cell cycle regulatory genes coincide with the onset of endoreduplication. During this process, there is a sharp reduction in the activity of the mitotic cyclin-dependent kinase (CDK) and activation of the S-phase CDK. It appears the M-phase CDK is stable, but its activity is blocked by a proteinaceous inhibitor. Coincidentally, the S-phase checkpoint protein, retinoblastoma (ZmRb), becomes phosphorylated, presumably releasing an E2F-type transcriptional regulator which promotes the expression of genes responsible for DNA synthesis. To investigate the role of these cell cycle proteins in endoreduplication, we have created transgenic maize plants that express various genes in an endosperm-specific manner using a storage protein (g-zein) promoter. During the first year of the grant, we constructed point mutations of the maize M-phase kinase, p34cdc2. One alteration replaced aspartic acid at position 146 with asparagine (p3630-CdcD146N), while another changed threonine 161 to alanine (p3630-CdcT161A). These mutations abolish the activity of the CDK. We hypothesized that expression of the mutant forms of p34cdc2 in endoreduplicating endosperm, compared to a control p34cdc2, would lead to extra cycles of DNA synthesis. We also fused the gene encoding the regulatory subunit of the M- phase kinase, cyclin B, under the g-zein promoter. Normally, cyclin B is expected to be destroyed prior to the onset of endoreduplication. By producing high levels of this protein in developing endosperm, we hypothesized that the M-phase would be extended, potentially reducing the number of cycles of endoreduplication. Finally, we genetically engineered the wheat dwarf virus RepA protein for endosperm-specific expression. RepA binds to the maize retinoblastoma protein and presumably releases E2F-like transcription factors that activate DNA synthesis. We anticipated that inactivation of ZmRb by RepA would lead to additional cycles of DNA synthesis.
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Delmer, Deborah P., Douglas Johnson, and Alex Levine. The Role of Small Signal Transducing Gtpases in the Regulation of Cell Wall Deposition Patterns in Plants. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570571.bard.

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The combined research of the groups of Delmer, Levine and Johnson has led to a number of interesting findings with respect to the function of the small GTPase Rac in plants and also opened up new leads for future research. The results have shown: 1) The Rac13 protein undergoes geranylgeranlyation and is also translocated to the plasma membrane as found for Rac in mammals; 2) When cotton Rac13 is highly- expressed in yeast, it leads to an aberrant phenotype reminiscent of mutants impaired in actin function, supporting a role for Rac13 in cytoskeletal organization; 3) From our searches, there is no strong evidence that plants contain homologs of the related CDC42 genes found in yeast and mammals; 4) We have identified a rather unique Rac gene in Arabidopsis that has unusual extensions at both the N- and C-terminal portions of the protein; 5) New evidence was obtained that an oxidative burst characterized by substantial and sustained production of H202 occurs coincident with the onset of secondary wall synthesis in cotton fibers. Further work indicates that the H202 produced may be a signal for the onset of this phase of development and also strongly suggests that Rac plays an important role in signaling for event. Since the secondary walls of plants that contain high levels of lignin and cellulose are the major source of biomass on earth, understanding what signals control this process may well in the future have important implications for manipulating the timing and extent of secondary wall deposition. 6) When the cotton Rac13 promoter is fused to the reporter gene GUS, expression patterns in Arabidopsis indicate very strong and specific expression in developing trichomes and in developing xyelm. Since both of these cell types are engaged in secondary wall synthesis, this further supports a role for Rac in signaling for onset of this process. Since cotton fibers are anatomically defined as trichomes, these data may also be quite useful for future studies in which the trichomes of Arabidopsis may serve as a model for cotton fiber development; the Rac promoter can therefore be useful to drive expression of other genes proposed to affect fiber development and study the effects on the process; 7) The Rac promoter has also been shown to be the best so far tested for use in development of a system for transient transformation of developing cotton fibers, a technique that should have many applications in the field of cotton biotechnology; 8) One candidate protein that may interact with Rac13 to be characterized further in the future is a protein kinase that may be analogous to the PAK kinase that is known to interact with Rac in mammals.
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Grumet, Rebecca, Rafael Perl-Treves, and Jack Staub. Ethylene Mediated Regulation of Cucumis Reproduction - from Sex Expression to Fruit Set. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696533.bard.

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Reproductive development is a critical determinant of agricultural yield. For species with unisexual flowers, floral secualdifferentation adds additional complexity, that can influenec productivity. The hormone ethylene has long, been known to play a primary role in sex determination in the Cucumis species cucumber (C. sativus) and melon (C. melo). Our objectives were to: (1) Determine critical sites of ethylene production and perception for sex determination; (2) Identify additional ethylene related genes associated with sex expression; and (3) Examine the role of environment ami prior fruit set on sex expression, pistillate flower maturation, and fruit set. We made progress in each of these areas. (1) Transgenic melon produced with the Arabidopsis dominant negative ethylene perception mutant gene, etrl-1, under the control of floral primordia targeted promoters [AP3 (petal and stamen) and CRC (carpel and nectary)], showed that ethylene perception by the stamen primordia, rather than carpel primordia, is critical for carpel development at the time of sex determination. Transgenic melons also were produced with the ethylene production enzyme gene. ACS, encoding l-aminocyclopropane-lcarboylate synthase, fused to the AP3 or CRC promoters. Consistent with the etr1-1 results, CRC::ACS did not increase femaleness; however, AP3::ACS reduced or eliminated male flower production. The effects of AP3:ACS were stronger than those of 35S::ACS plants, demonstratin g the importance of targeted expression, while avoiding disadvantages of constitutive ethylene production. (2) Linkage analysis coupled with SNP discovery was per formed on ethylene and floral development genes in cucumber populations segregating for the three major sex genes. A break-through towards cloning the cucumber M gene occurred when the melon andromonoecious gene (a), an ACS gene, was cloned in 2008. Both cucumber M and melon a suppress stamen development in pistillate flowers. We hypothesized that cucumber M could be orthologous to melon a, and found that mutations in CsACS2 co-segregated perfectly with the M gene. We also sought to identify miRNA molecules associated with sex determination. miRNA159, whose target in Arabidopsis is GAMYB[a transcription factor gene mediating response to10 gibberellin (GA)], was more highly expressed in young female buds than male. Since GA promotes maleness in cucumber, a micro RNA that counteracts GAMYB could promote femaleness. miRNA157, which in other plants targets transcription factors involved in flower development , was expressed in young male buds and mature flower anthers. (3) Gene expression profiling showed that ethylene-, senescence-, stress- and ubiquitin-related genes were up-regulated in senescing and inhibited fruits, while those undergoing successful fruit set up-regulated photosynthesis, respiration and metabolic genes. Melon plants can change sex expression in response to environmental conditions, leading to changes in yield potential. Unique melon lines with varying sex expression were developed and evaluated in the field in Hancock, Wisconsin . Environmental changes during the growing season influenced sex expression in highly inbred melon lines. Collectively these results are of significance for understanding regulation of sex expression. The fact that both cucumber sex loci identified so far (F and M) encode isoforms of the same ethylene synthesis enzyme, underscores the importance of ethylene as the main sex determining hormone in cucumber. The targeting studies give insight into developmental switch points and suggest a means to develop lines with earlier carpel-bearing flower production and fruit set. These results are of significance for understanding regulation of sex expression to facilitate shorter growing seasons and earlier time to market. Field results provide information for development of management strategies for commercial production of melon cultivars with different sex expression characteristics during fruit production.
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