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Journal articles on the topic 'Synthesis of fused sulfonamide'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Beduru, Srinivas, and Andrei G. Kutateladze. "Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides." Molecules 28, no. 18 (2023): 6549. http://dx.doi.org/10.3390/molecules28186549.

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Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex polyheterocycles. In our prior work we have employed ESIPT in aromatic o-keto amines and amides, leading to diverse primary photoproducts—complex quinolinols or azacanes possessing a fused lactam moiety—which could additionally be modified in short, high-yielding postphotochemical reactions to further grow complexity of the heterocyclic core scaffold and/or t

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2

Laha, Joydev K., Rohan A. Bhimpuria, and Aitha Manoj Kumar. "Post-synthetic diversification of pyrrole-fused benzosultams via trans-sulfonylations and reactions on the periphery of pyrrole." Organic Chemistry Frontiers 4, no. 11 (2017): 2170–74. http://dx.doi.org/10.1039/c7qo00440k.

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The synthesis of pyrrole fused benzosultams and their trans-sulfonylation reactions providing workable access to (NH)-2-arylpyrroles containing ortho-sulfonamide functionality and fluorene tethered pyrrole fused benzosultam has been described.

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3

Manojit, Pal, Rao Veeramaneni Venugopal, Kumar Sanjeev, B. Lohray Vidya, and Rao Yeleswarapu Koteswar. "Synthesis of fused sulfonamide (1,1-dioxoisothiazole)substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors." Journal of Indian Chemical Society Vol. 80, Dec 2003 (2003): 1095–101. https://doi.org/10.5281/zenodo.5839785.

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Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad-500 049, India E-mail : manojitpal @drreddys.com; koteswarraoy @drreddys.com                    Fax : 91-40-23045438/23045007 <em>Manuscript received 15 October 2003</em> First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[<em>d</em>]isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-nuoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3- dicarbonyl compounds. A

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4

Arshad, Nasima, Yasir Mehmood, Hammad Ismail, et al. "Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses." RSC Advances 14, no. 47 (2024): 35047–63. http://dx.doi.org/10.1039/d4ra06412g.

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This work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4-d]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-d)isoxazole-based fused ring heterocyclic system.

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5

Donthukurthi, Saisuryanarayana, Devdatt J. Patel, Rakesh I. Patel, and Piyush J. Vyas. "Synthesis, Characterization and Antimicrobial Activity of Thiazolo-oxazine Fused Heterocyclic Derivatives, Based on Benzene Sulfonyl Hydrazide." Oriental Journal Of Chemistry 39, no. 3 (2023): 721–26. http://dx.doi.org/10.13005/ojc/390323.

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Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. (1a-e) SBSZ were then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) were then condensed with 5-nitro-2furfuralidine derivatives i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These derivatives were further condensed with phenyl urea to yield fused heterocyclic derivatives i.e. N-(2-substituted-7-(5-nitrofuran-2-yl)-5-(phenylamino)-2H-thiazolo[5,4-e] [1,3]oxazin-3(3aH)-yl

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6

Ito, Hideto, Tomoya Harada, Hirohisa Ohmiya, and Masaya Sawamura. "Intramolecular hydroamination of alkynic sulfonamides catalyzed by a gold–triethynylphosphine complex: Construction of azepine frameworks by 7-exo-dig cyclization." Beilstein Journal of Organic Chemistry 7 (July 8, 2011): 951–59. http://dx.doi.org/10.3762/bjoc.7.106.

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The gold-catalyzed, seven-membered ring forming, intramolecular hydroamination of alkynic sulfonamides has been investigated. The protocol, with a semihollow-shaped triethynylphosphine as a ligand for gold, allowed the synthesis of a variety of azepine derivatives, which are difficult to access by other methods. Both alkynic sulfoamides with a flexible linear chain and the benzene-fused substrates underwent 7-exo-dig cyclization to afford the nitrogen-containing heterocyclic seven-membered rings, such as tetrahydroazepine and dihydrobenzazepine, in good yields.

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7

S, Priyanka. "Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles." Der Pharma Chemica 14, no. 1 (2022): 2. https://doi.org/10.5281/zenodo.13353756.

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Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. The isoquinoline ring in these natural compounds derives from the aromatic amino acid tyrosine.

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8

Said, Mohamed A., Wagdy M. Eldehna, Alessio Nocentini, et al. "Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation." European Journal of Medicinal Chemistry 189 (March 2020): 112019. http://dx.doi.org/10.1016/j.ejmech.2019.112019.

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9

Sedenkova, Kseniya N., Kristian S. Andriasov, Marina G. Eremenko, et al. "Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity." Molecules 27, no. 11 (2022): 3546. http://dx.doi.org/10.3390/molecules27113546.

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The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance. Among the works of the last decade, a literature search revealed spirothiazamenthane, which has served as a lead in the development of derivatives active against resistant viral strains. In this work, we studied the novel molecular scaffold, which resembles spirothiazamenthane, but combines isoxazoline as a heterocycle and cyclooctane ring as a hydrop

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10

Sanad, Sherif M. H., and Ahmed E. M. Mekky. "New pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors." Canadian Journal of Chemistry 99, no. 11 (2021): 900–909. http://dx.doi.org/10.1139/cjc-2021-0121.

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In the current study, we reported the tandem synthesis of two series of arene-linked pyrimidinone hybrids with related fused thieno[2,3-b]pyridine moiety. The target hybrids were prepared, in moderate to excellent yields, by the reaction of a ternary mixture of the appropriate of 3-aminothieno[2,3-b]pyridine-2-carboxylate, DMF-DMA, and a series of aryl amines in dioxane at 110 °C for 8 h. The antibacterial activity of the new hybrids was estimated against six susceptible ATCC strains. Hybrids 5g and 7g, linked to a sulfonamide unit, showed the best efficacy against S. aureus and E. faecalis st

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11

Basak, Amit, Subrata Mandal, Amit Kumar Das, and Valerio Bertolasi. "Benzene fused monocyclic enediynyl amides: synthesis, reactivity and DNA-Cleavage activity in comparison to the corresponding sulfonamides." Bioorganic & Medicinal Chemistry Letters 12, no. 6 (2002): 873–77. http://dx.doi.org/10.1016/s0960-894x(02)00029-x.

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12

Mallam, Vasudha, Vijayakumar Allam, and G. Brahmeshwari. "Synthesis and Biological Evaluation of Fused Imidazo[4,5,1-kl]phenothiazine-4-sulfonamides as Potent Antibacterial and Anticancer Agents." Russian Journal of Bioorganic Chemistry 49, no. 6 (2023): 1381–88. http://dx.doi.org/10.1134/s1068162023060183.

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13

Basak, Amit, Subrata Mandal, Amit Kumar Das, and Valerio Bertolasi. "ChemInform Abstract: Benzene Fused Monocyclic Enediynyl Amides (VIII): Synthesis, Reactivity and DNA-Cleavage Activity in Comparison to the Corresponding Sulfonamides." ChemInform 33, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.200229171.

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14

Xu, Zhiqiang, Ming-Xing Zhang, Guangjin Li, et al. "Naphthalimide-sulfonamide fused dansyl-sulfonamide fluorescent probe for tracking glutathione of lysosome with a dual-emission manner." Dyes and Pigments 171 (December 2019): 107685. http://dx.doi.org/10.1016/j.dyepig.2019.107685.

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15

Mondal, Shovan. "Sulfonamide synthesis under green conditions." Synthetic Communications 51, no. 7 (2021): 1023–44. http://dx.doi.org/10.1080/00397911.2020.1870238.

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16

Lopez, Marie, Laurent F. Bornaghi, Hugues Driguez, and Sally-Ann Poulsen. "Synthesis of Sulfonamide-Bridged Glycomimetics." Journal of Organic Chemistry 76, no. 9 (2011): 2965–75. http://dx.doi.org/10.1021/jo2001269.

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17

Carvalho, Eliana F. A., Mário J. F. Calvete, Augusto C. Tomé, and José A. S. Cavaleiro. "Synthesis of sulfonamide-substituted phthalocyanines." Tetrahedron Letters 50, no. 49 (2009): 6882–85. http://dx.doi.org/10.1016/j.tetlet.2009.09.128.

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18

Poeira, Diogo L., João Macara, Hélio Faustino, Jaime A. S. Coelho, Pedro M. P. Gois, and M. Manuel B. Marques. "Hypervalent Iodine Mediated Sulfonamide Synthesis." European Journal of Organic Chemistry 2019, no. 15 (2019): 2695–701. http://dx.doi.org/10.1002/ejoc.201900259.

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19

Baraa G. Alani, Khulood S Salim, Alaa Saleh Mahdi, and Ahmed Alaa Al-Temimi. "Sulfonamide derivatives: Synthesis and applications." International Journal of Frontiers in Chemistry and Pharmacy Research 4, no. 1 (2024): 001–5. http://dx.doi.org/10.53294/ijfcpr.2024.4.1.0021.

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Sulfonamides belong to an important class of compounds which showed wide ranges of biological activities like antibacterial, antiviral, diuretic, hypo-glycemic, anticancer, anti-inflammatory and recently anti-covid-19. Over the last few decades, various pharmacological activities of sulfonamide conjugates were published. Moreover, many lead compounds with sulfonamide functionality are also in clinical trial for the treatment of various medical conditions. For these reasons, development of an efficient process for the synthesis of sulfonamides has always been in the focus for research in organi

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20

Irfan, Ali, Sajjad Ahmad, Saddam Hussain, et al. "Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides." Applied Sciences 11, no. 12 (2021): 5702. http://dx.doi.org/10.3390/app11125702.

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Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of pharmacological activities. Therefore, the therapeutic potential and biomedical applications of quinoxalines have been enhanced by incorporation of the sulfonamide group into their chemical framework. The present review surveyed the literature on the preparation, biological activities and structure-activity relationship (SAR) of quinoxaline su

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21

Iakovenko, Roman O., Daniel Chrenko, Jozef Kristek, et al. "Heteroaryl sulfonamide synthesis: scope and limitations." Organic & Biomolecular Chemistry 20, no. 15 (2022): 3154–59. http://dx.doi.org/10.1039/d2ob00345g.

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22

Aly, M. M. "Synthesis of Some Novel Sulfonamide Derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 7 (2007): 1497–506. http://dx.doi.org/10.1080/10426500701242954.

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23

Ottens-Hildebrandt, Stephan, Thomas Schmidt, Jörg Harren, and Fritz Vögtle. "Sulfonamide-based catenanes — regioselective template synthesis." Liebigs Annalen 1995, no. 10 (1995): 1855–60. http://dx.doi.org/10.1002/jlac.1995199510260.

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24

Liu, Zhi-Wei, Fan Liu, Chun-Tao Shao, Guo-Ping Yan, and Jiang-Yu Wu. "Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes." Molecules 29, no. 12 (2024): 2774. http://dx.doi.org/10.3390/molecules29122774.

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A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation of N-butyl-4-ethyldiamino-1,8-naphthalene imide (NI) into sulfonamide (SN) and sulfadiazine (SD) as the tumor-targeting groups, respectively. These derivatives were further characterized by mass spectrometry (MS), nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy

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25

Sajid Mahmood. "Design, Synthesis and Biological Assessment of N-Substituted Pronestyl Sulfonamide Analogues." Power System Technology 48, no. 1 (2024): 1062–71. https://doi.org/10.52783/pst.371.

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Pronestyl sulfonamide N-(2-(diethylamino)ethyl-4-(phenylsulfonamido)benzamide) and their derivatives were synthesized to check antibacterial activity. Procainamide (Pronestyl) was reacted with benzene sulphonyl chloride in the presence of 10% Na2CO3 at room temperature to form the product N-(2-(diethylamino)ethyl-4-(phenylsulfonamido)benzamide) (3). This synthesized compound was used further for the synthesis of pronestyl sulfonamide derivatives (5a-f) by the reaction of alkyl/aralkyl halides with Pronestyl sulfonamide by using LiH and DMF. The antibacterial activity of these compounds were pe

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26

Ashokan, D., and K. Rajathi. "Synthesis, Structural Identification and Biological Potencies of Quinolinium Sulfonamide Ionic Liquids." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 03 (2023): 342–49. http://dx.doi.org/10.25004/ijpsdr.2023.150315.

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Members of the quinoline family include several alkaloids. Alkaloids are found in foods and beverages that humans consume daily and in various stimulants. Among many other activities, they act against inflammation, cancer, bacteria, fungi and pain. Modifications of the alkyl chain after N-alkylation can alter the physicochemical properties and affect its multifunctional properties. This article describes the preparation and structural identification of five quinolinium sulfonamide ionic liquids that differ in N-alkylation functional group and chain length. Functional group and alkyl chain leng

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27

Sadawarte, Gautam, Samadhan Jagatap, Mukesh Patil, Vasant Jagrut, and Jamatsing Darbarsing Rajput. "Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent." European Journal of Chemistry 12, no. 3 (2021): 279–83. http://dx.doi.org/10.5155/eurjchem.12.3.279-283.2118.

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This research work describes the synthesis of a new series of heterocyclic compounds, namely sulfonamide derivatives. Sulfonamides are a diverse class of organic compounds having significant and potent biological activities. Diverse synthetic methods have been engaged to build up its various derivatives for different biological functions. In this study, the production of novel pyridine-based heterocyclic compounds having sulfonamide moieties has been elaborated. The obtained sulfonamide-based pyridine scaffold was used to investigate their alpha-amylase inhibition activity. The structures of f

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28

Bell, S., A. Bonadio, and KG Watson. "Synthesis of 3-Methyl-4-oxo-3,4-dihydroquinazoline-5-sulfonamide and a Herbicidal Sulfonylurea Derivative." Australian Journal of Chemistry 48, no. 2 (1995): 227. http://dx.doi.org/10.1071/ch9950227.

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Starting with 6-chloroquinazolin-4(3H)-one (5), a convenient synthesis of 3-methyl-4-oxo-3,4-dihydroquinazoline-5-sulfonamide (11) has been achieved. The sulfonamide (11) was used to prepare a highly herbicidal sulfonylurea derivative (13).

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29

Balsells, Jaume, Lupe Mejorado, Mimi Phillips, et al. "Synthesis of chiral sulfonamide/Schiff base ligands." Tetrahedron: Asymmetry 9, no. 23 (1998): 4135–42. http://dx.doi.org/10.1016/s0957-4166(98)00431-5.

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30

Ng, Karno, Ratnasamy Somanathan, and Patrick J. Walsh. "Synthesis of homochiral pentadentate sulfonamide-based ligands." Tetrahedron: Asymmetry 12, no. 12 (2001): 1719–22. http://dx.doi.org/10.1016/s0957-4166(01)00292-0.

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31

Flores-López, Lucia Z., Miguel Parra-Hake, Ratnasamy Somanathan, Fernando Ortega, and Gerardo Aguirre. "Synthesis of Some New Chiral Sulfonamide Ligands." Synthetic Communications 30, no. 1 (2000): 147–55. http://dx.doi.org/10.1080/00397910008087302.

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32

Ponizovsky, Michail G., Artem M. Boguslavsky, Mikhail I. Kodess, Valery N. Charushin, and Oleg N. Chupakhin. "Synthesis of fused quinoxalines." Mendeleev Communications 12, no. 2 (2002): 68–70. http://dx.doi.org/10.1070/mc2002v012n02abeh001560.

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33

Walton, David J. "Synthesis of fused heterocycles." Endeavour 12, no. 3 (1988): 149. http://dx.doi.org/10.1016/0160-9327(88)90145-7.

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34

Banfi, Luca, and Giuseppe Guanti. "Synthesis ofN-Fused “Lactendiynes”." European Journal of Organic Chemistry 1998, no. 8 (1998): 1543–48. http://dx.doi.org/10.1002/(sici)1099-0690(199808)1998:8<1543::aid-ejoc1543>3.0.co;2-z.

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35

Y. Saour, Kawkab, Ridha I. Al-Bayati, and Mohammed K. Hadi. "Synthesis of New Coumarin and 2-quinolone Derivatives with Expected Biological Activities." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 2 (2017): 42–50. http://dx.doi.org/10.31351/vol21iss2pp42-50.

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A series of new coumarin and N-amino-2-quinolone derivatives have been synthesized. The reaction of coumarin (1) with excess of Hydrazine hydrate 98% yielded 1-amino-2-quinolone (2), Compound (2) was reacted with different Sulfonyl chloride to yield Sulfonamides [ N-(2-oxoquinolin-1(2H)-yl) methane sulfonamide (3), N-(2-oxoquinolin-1(2H)-yl) Benzene sulfonamide (4) and 4-methyl-N-(2-oxoquinolin-1(2H)-yl) benzene sulfonamide (5) ], while reaction of 2-(4-methyl-2-oxo-2H-chromen-7-yloxy) acetic acid (8) with different amines yielded compounds [ 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(2-oxoquino

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36

Hemming, Karl, and Christina Loukou. "Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides – sulfonamide analogues of the 1,4-benzodiazepines." Journal of Chemical Research 2005, no. 1 (2005): 1–12. http://dx.doi.org/10.3184/0308234053431013.

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Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

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37

Alshibl, Hanan M., Ebtehal S. Al-Abdullah, Mogedda E. Haiba, et al. "Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents." Molecules 25, no. 14 (2020): 3251. http://dx.doi.org/10.3390/molecules25143251.

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New pyranocoumarin and coumarin-sulfonamide derivatives were prepared and evaluated for their antioxidant, antimicrobial, and/or anti-inflammatory activities. Coumarin-sulfonamide compounds 8a–d demonstrated significant antioxidant activity, while 7c,d, 8c,d, and 9c,d exhibited antimicrobial activity equal to or higher than the standard antimicrobials against at least one tested microorganism. Regarding the anti-inflammatory testing, pyranocoumarins 2b, 3a,b and 5c and coumarin-sulfonamide compound 9a showed more potent antiproteinase activity than aspirin in vitro; however, five compounds wer

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38

Rubab, Laila, Sumbal Afroz, Sajjad Ahmad, et al. "An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents." Molecules 27, no. 5 (2022): 1604. http://dx.doi.org/10.3390/molecules27051604.

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Coumarin is an important six-membered aromatic heterocyclic pharmacophore, widely distributed in natural products and synthetic molecules. The versatile and unique features of coumarin nucleus, in combination with privileged sulfonamide moiety, have enhanced the broad spectrum of biological activities. The research and development of coumarin, sulfonamide-based pharmacology, and medicinal chemistry have become active topics, and attracted the attention of medicinal chemists, pharmacists, and synthetic chemists. Coumarin sulfonamide compounds and analogs as clinical drugs have been used to cure

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39

Allahyani, Mamdouh, Mazen Almehmadi, Osama Abdulaziz, et al. "Synthesis and in vitro antimicrobial screening of some 5-methyl-2-substituted phenyl-3- (phenylsulfonyl)thiazolidin-4-ones." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 499. https://doi.org/10.59467/ijhc.2024.34.499.

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The synthesis of some new thiazolidine-sulfonamide derivatives was achieved in two steps. In the first step, appropriate aryl aldehyde reacted with benzene sulfonamide to yield N-arylidene benzene sulfonamide derivatives (1a-h). In the second step, compounds (1a-h) reacted with thiolactic acid to give the 5-methyl-2-substituted phenyl-3-(phenylsulfonyl) thiazolidin-4-one derivatives (2a-h). The compounds 2a-h were screened for their in vitro antimicrobial activity by agar disc diffusion method. The results showed that compounds 2b, 2c, and 2d exhibited anti-microbial activity against the teste

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40

Gill, Manjinder, Dinesh Tanwar, and Vaghela Surendrabhai. "An Efficient and Practical Process for the Synthesis of Glimepiride." Synlett 28, no. 18 (2017): 2495–98. http://dx.doi.org/10.1055/s-0036-1590836.

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A novel and simple approach to the synthesis of glimepiride is reported. It involves the preparation of a carbamate of 3-ethyl-4-methyl-1H-pyrrol-2(5H)-one, followed by its reaction with 4-(2-aminoethyl)benzenesulfonamide to produce the intermediate sulfonamide. This sulfonamide, upon reaction with phenyl (trans-4-methylcyclohexyl)carbamate, gave glimepiride. This process avoids the use of phosgene, isocyanates, or chloroformates. Furthermore, sulfonation of the aryl group was eliminated, rendering the product free of the impurities reported in earlier processes.

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41

Preeti, Preeti, and Krishna Nand Singh. "A diversity-oriented novel regioselective synthesis of sulfonamide–thiazolidinone hybrids." New Journal of Chemistry 43, no. 16 (2019): 6288–93. http://dx.doi.org/10.1039/c9nj00055k.

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42

Zhang, Shu-Guang, Yu-Qiang Wan, Ya Wen, and Wei-Hua Zhang. "Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation." Molecules 27, no. 20 (2022): 6904. http://dx.doi.org/10.3390/molecules27206904.

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Coumarin compounds have a variety of biological activities such as anti-tumor, anti-coagulation, anti-HIV, anti-fungal, and insecticidal. Amide and sulfonamide compounds have been used as fungicides for half a century, and dozens of varieties have been developed so far. This study focused on the introduction of carboxamide and sulfonamide moieties in a coumarin core to discover novel derivatives. Based on this strategy, we synthesized two series of novel carboxamide and sulfonamide substituted coumarin derivatives, and their fungicidal activity was also investigated. Some designed compounds po

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43

ES, Hanan Ali, and AM Badawi. "Synthesis, characterization and surface properties of bis-sulfonamide, sulfonamide-imine and sultam based nonionic surfactants." Journal of Scientific and Innovative Research 5, no. 5 (2016): 182–86. http://dx.doi.org/10.31254/jsir.2016.5506.

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In an effort to develop new classes of nonionic surfactants, the surface tension properties and phase behavior of a novel series of bis-sulfonamide, sulfonamide-imine and sultam-surfactants have been investigated. These surfactants possess SO2NH moieties that display comparative cytotoxicities. In this paper the presence of the – SO2NH functional moiety and the partition coefficient (oil/water) measurement demonstrate good biodegradability and lipophilicity. On the other hand, by means of the located thermodynamic point, the solubilization can be considered as a normal partitioning of the drug

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44

N. Omar, Tagreed. "Synthesis of Schiff Bases of Benzaldehyde and Salicylaldehyde as Anti-inflammatory Agents." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 16, no. 2 (2017): 5–11. http://dx.doi.org/10.31351/vol16iss2pp5-11.

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Three Schiff bases from Benzaldehyde and Salicylaldehyde have been synthesized (A, 1and 2) and two of them (1and 2) have been tested for anti-inflammatory activity. The p-aminobenzene sulfonamide has been synthesized from acetanilide through the addition of excess chlorosulfonic acid then concentrated ammonia solution; Schiff base of this derivative (2) exhibited good level of activity against egg-white induced edema in rat hind paw, while the other tested derivative exhibited no activity. Key words: Schiff bases, sulfonamide derivatives, salicylaldehyde

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Stenfors, Brock Anton, and Felix Nyuangem Ngassa. "The synthesis and crystallographic characterization of 4-methylbenzenesulfonamide derivatives." European Journal of Chemistry 12, no. 2 (2021): 109–16. http://dx.doi.org/10.5155/eurjchem.12.2.109-116.2064.

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The sulfonamide moiety is present among a variety of biologically significant compounds. A facile synthesis is necessary to produce a variety of sulfonamides with the potential to improve human health. Herein, we report a facile methodology for the synthesis of 4-methylbenzenesulfonamides, amenable to a broad range of nitrogen nucleophiles. Implementing a semi-miscible biphasic solvent system resulted in higher yields, decreased reaction times, and a simplified workup over preliminary methods. Additionally, the crystal structures of five novel sulfonamide compounds and two polymorphs, have bee

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Yanni, Amal S., Zarif H. Khalil, and Ahmed A. Timmawy. "Synthesis of some new sulfonamide derivatives of 7-chloroquinoline-5,8-dione and pyridocarbazolediones." Collection of Czechoslovak Chemical Communications 56, no. 7 (1991): 1489–94. http://dx.doi.org/10.1135/cccc19911489.

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Interaction of 6-chloroquinoline-5,8-dione hydrochloride (I) or 6,7-dichloroquinoline-5,8-dione (II) with sulfa drug in ethanol containing diethylaniline afforded 7-substituted sulfonamide-10H-pyrido[3,2-b]carbazole-5,11-dione (III), and sulfonamide derivatives of 7-chloroquinoline-5,8-diones (IV). Moreover the reaction of II with arylamine in pyridine afforded substituted 6H-pyrido[2,3-b]carbazole-5,11-dione (V). The structure of the compounds was determined by elemental and spectral analysis, and by chemical reaction.

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He, Shi-Chao, Hui-Zhen Zhang, Hai-Juan Zhang, Qing Sun, and Cheng-He Zhou. "Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration." Medicinal Chemistry 16, no. 1 (2020): 104–18. http://dx.doi.org/10.2174/1573406414666181106124852.

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Objective: Due to the incidence of resistance, a series of sulfonamide-derived 1,2,4- triazoles were synthesized and evaluated. Method: The novel sulfonamide-derived 1,2,4-triazoles were prepared starting from commercial acetaniline and chlorosulfonic acid by sulfonylation, aminolysis, N-alkylation and so on. The antimicrobial activity of the synthesized compounds were evaluated in vitro by two-fold serial dilution technique. Results: In vitro antimicrobial evaluation found that 2-chlorobenzyl sulfonamide 1,2,4-triazole 7c exhibited excellent antibacterial activities against MRSA, B. subtilis,

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Wang, Yu, Shuai Lu, Xu-Qing Wang, Yan-Fei Niu, Heng Wang, and Wei Wang. "Synthesis, structure elucidation and functionalization of sulfonamide [2]catenanes." Organic Chemistry Frontiers 8, no. 18 (2021): 4994–5001. http://dx.doi.org/10.1039/d1qo00691f.

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Godet, Monique. "Synthesis of Polyamides-11 with Sulfonamide End Groups." Journal of Macromolecular Science: Part A - Chemistry 24, no. 5 (1987): 539–55. http://dx.doi.org/10.1080/00222338708068140.

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Deng, Xiaohu, and Neelakandha S. Mani. "A facile, environmentally benign sulfonamide synthesis in water." Green Chemistry 8, no. 9 (2006): 835. http://dx.doi.org/10.1039/b606127c.

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