Relevant bibliographies by topics / Synthesis of ketamine

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Academic literature on the topic 'Synthesis of ketamine'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Synthesis of ketamine"

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Bevilacqua, Laura, Alex Charney, Charlotte R. Pierce, et al. "Role of nitric oxide signaling in the antidepressant mechanism of action of ketamine: A randomized controlled trial." Journal of Psychopharmacology 35, no. 2 (2021): 124–27. http://dx.doi.org/10.1177/0269881120985147.

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Ketamine is an N-methyl-D-aspartate receptor antagonist with rapid antidepressant effects. Studies suggest that inhibition of nitric oxide synthesis plays a role in the mechanism of action of ketamine. This randomized, placebo-controlled study investigated whether co-administration of sodium nitroprusside, a nitric oxide donor, compared to placebo, would attenuate the antidepressant and dissociative effects of ketamine. Sixteen ketamine responders were randomized to a double-blind infusion of ketamine co-administered with placebo or sodium nitroprusside. Our findings show no difference between
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Malhi, Gin S., Yulisha Byrow, Frederick Cassidy, et al. "Ketamine: stimulating antidepressant treatment?" BJPsych Open 2, no. 3 (2016): e5-e9. http://dx.doi.org/10.1192/bjpo.bp.116.002923.

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SummaryThe appeal of ketamine – in promptly ameliorating depressive symptoms even in those with non-response – has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives – derived from evidence and clinical experience – and to consider strategies for future investigations.
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Camargo, Anderson, and Ana Lúcia S. Rodrigues. "Novel Targets for Fast Antidepressant Responses: Possible Role of Endogenous Neuromodulators." Chronic Stress 3 (January 2019): 247054701985808. http://dx.doi.org/10.1177/2470547019858083.

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The available medications for the treatment of major depressive disorder have limitations, particularly their limited efficacy, delayed therapeutic effects, and the side effects associated with treatment. These issues highlight the need for better therapeutic agents that provide more efficacious and faster effects for the management of this disorder. Ketamine, an N-methyl-D-aspartate receptor antagonist, is the prototype for novel glutamate-based antidepressants that has been shown to cause a rapid and sustained antidepressant effect even in severe refractory depressive patients. Considering t
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Blum, Kenneth, Todd C. Pappas, Bryan Clifton, et al. "Rapid Anti-Depressant Relief by Ketamine: Exploring A Complex Mechanism of Action." Current Psychopharmacology 8, no. 2 (2019): 99–112. http://dx.doi.org/10.2174/2211556008666190827150018.

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Background: Suicide rates and narcotic overdose have doubled since 2000. At least 30 percent of people with major depression are Treatment-Resistant (TR) and require novel therapeutics. ketamine at low doses has been shown in clinical trials to induce a rapid, short-lived anti-suicide and anti-depressant effect. Objective: To review the potential mechanism of action of ketamines’ alleviation of depressive symptoms from both animal and available human literature. Methods: This is a synthesis of information from papers listed in PUBMED Central. Although not exhaustive, this review highlights the
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Martin, D. C., A. M. Carr, R. R. Livingston, and C. A. Watkins. "Effects of ketamine and fentanyl on lung metabolism in perfused rat lungs." American Journal of Physiology-Endocrinology and Metabolism 257, no. 3 (1989): E379—E384. http://dx.doi.org/10.1152/ajpendo.1989.257.3.e379.

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The effects of ketamine and fentanyl on serotonin (5-hydroxytryptamine; 5-HT) metabolism, angiotensin-converting enzyme (ACE), and protein synthesis (PS) were investigated in an isolated lung model. Rat lungs were perfused in situ with a blood-free physiological salt solution. The pulmonary vasculature was exposed to ketamine (0.005-2.1 mM) or fentanyl (1.8-4.5 microM) for up to 2 h. After 1 h, accumulation of 5-[14C]hydroxyindoleacetic acid (5-HIAA) by the lung was monitored as an index of 5-HT metabolism. ACE activity was estimated from hydrolysis of [3H]benzoylphenylalanyl-alanyl-proline, a
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McQueen, Angela L., and Steven A. Baroletti. "Adjuvant Ketamine Analgesia for the Management of Cancer Pain." Annals of Pharmacotherapy 36, no. 10 (2002): 1614–19. http://dx.doi.org/10.1345/aph.1a256.

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OBJECTIVE: To review the clinical literature evaluating the utilization of intravenous ketamine for the management of cancer-related pain, to summarize the data that suggest ketamine is an appropriate adjuvant method of providing analgesia and to report a case of successful pain management using ketamine in a patient with recurrent testicular cancer at our institution. DATA SOURCES: Primary literature was identified through a MEDLINE search (1966–March 2002), and additional information was obtained through secondary and tertiary sources. DATA SYNTHESIS: The available data suggest that suppleme
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Sulake, Rohidas S., Chinpiao Chen, Huei-Ru Lin, and Ahai-Chang Lua. "Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d4." Bioorganic & Medicinal Chemistry Letters 21, no. 19 (2011): 5719–21. http://dx.doi.org/10.1016/j.bmcl.2011.08.021.

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Chen, Lu, Yong Gong, and Rhys Salter. "Synthesis of carbon-14 labeled ketamine and norketamine." Journal of Labelled Compounds and Radiopharmaceuticals 61, no. 11 (2018): 864–68. http://dx.doi.org/10.1002/jlcr.3669.

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Gohari, Seyed Jamaladdin, Abdollah Javidan, Abolghasem Moghimi, Mohammad Javad Taghizadeh, and Maryam Iman. "Novel enantioselective synthesis of (S)-ketamine using chiral auxiliary and precursor Mannich base." Canadian Journal of Chemistry 97, no. 5 (2019): 331–36. http://dx.doi.org/10.1139/cjc-2017-0731.

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Ketamine has been extensively used as an anesthetic drug. Chiral auxiliaries such as tert-butanesulfinamide (TBSA) can be used for the asymmetric synthesis of (S)-ketamine. Condensation of TBSA with ketones provides tert-butanesulfinylimines in consistently high yields. The tert-butanesulfinyl group actuates the imine for nucleophilic addition, is a potent chiral directing group, and after nucleophilic addition is easily dissociated by intervention with acid solution. To prepare 2-(N-piperidinomethyl)-1-phenylcyclohexylamine (1), we started with the cyclohexanone and using Mannich reaction ach
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Lai, Isaac, Suk-Chang Hong, and John N. Davisson. "Ketamine Metabolism: Identification and Synthesis of a Deaminated Product." Journal of Pharmaceutical Sciences 74, no. 4 (1985): 486–88. http://dx.doi.org/10.1002/jps.2600740425.

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Dissertations / Theses on the topic "Synthesis of ketamine"

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Gali, Meghanath. "Synthesis of Small Molecule Inhibitors of Janus Kinase 2, Phosphodiesterase IV, GABAA and NMDA receptors: Investigation of Mcmurry, Mannich and Chemoenzymatic Strategies." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3110.

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Stilbenoids possess a wide range of biological properties such as, anticancer, antiplatelet aggregation, antiestrogenic, antibacterial, antifungal and antiatherogenic, etc. Owing to these therapeutic values, a great deal of attention attracted in the synthesis of derivatives of stilbenes. During the course of the study, G6 a novel stilbenoid was discovered, through high throughput screening, to be a potent inhibitor of mutated JAK2-V617F. The mutated JAK2 variant has been implicated in various myeloproliferative disorders (MPDs) including polycythemia vera (PV), essential thrombocythemia (ET)
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Larabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.

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L’objectif de ce travail a été de développer deux approches analytiques dédiées à l’analyse toxicologique des nouveaux produits de synthèse (NPS) dans différentes matrices biologiques (sang, urine et cheveux). La première est basée sur le criblage non ciblé par chimiluminescence sur biopuces et chromatographie liquide couplée à la spectrométrie de masse haute résolution (LC-HRMS) et la deuxième correspond à un criblage ciblé par spectrométrie de masse en tandem (LC-MS/MS). Ces deux approches ont ensuite été appliquées dans des études observationnelles pour évaluer la consommation de NPS dans d
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Stuchlíková, Lucie. "Syntéza izotopově značeného ketaminu." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-298068.

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In this work were synthesized ketamine isotopomers. Ketamine is used in human medicine and veterinary sectors. It has very broad spectrum of pharmacological effects: anesthetic, analgesic, hallucinogenic, bronchodilator, cardiovascular and antidepressive, which is currently in the research. At first was synthesized precursor of ketamine, N- desmethylketamine which was subsequently labeled the deuterium, tritium and carbon- 14. For the determination of purity and identity mass spectrometry and nuclear magnetic resonance spectroscopy were used. KEY WORDS synthesis of ketamine, ketamine, N-desmet
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Welters, Ingeborg Dorothea Maria [Verfasser]. "Effekte von Morphin, Fentanyl und Ketamin auf leukozytäre Funktion, Transkriptionsfaktoren und Interleukin-8-Synthese / vorgelegt von Ingeborg Dorothea Maria Welters." 2005. http://d-nb.info/976074060/34.

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Books on the topic "Synthesis of ketamine"

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European Monitoring Centre for Drugs and Drug Addiction. Report on the risk assessment of ketamine in the framework of the joint action on new synthetic drugs. Office for Official Publications of the European Communities, 2002.

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Journal articles
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