Relevant bibliographies by topics / Synthesis of Pyrazoles

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Synthesis of Pyrazoles'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Synthesis of Pyrazoles"

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M., K. A. IBRAHIM, H. H. ELGHANDOUR A., S.M. ABDBL-SAYED G., and S.M. ABDEL FATTAH A. "Synthesis of Pyrazoles and Fused Pyrazoles. Novel Synthesis of Pyrano[2,3-c]pyrazole, Thieno[2,3-c]pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives." Journal of Indian Chemical Society Vol. 74, Mar 1997 (1997): 206–8. https://doi.org/10.5281/zenodo.5885902.

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Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt <em>Manuscript received 17 November 1994, revised 26 July 1995, accepted 28 September 1995</em> 3-Metbyl-1-thiocarbamoylpyrazoi-5-one (1) reacted with <em>p</em>-metbylpbenscyl bromide to give 3-metbyl-1(4-tbiazol-2-yl)pyrazol-5-one (2). Compounds 1 and 2 were reacted with&nbsp;reagents such as &alpha;-cyanocinnamo. benzaldehyde, elemental suJphurlmalononltrlle, benzenediazomum chloride, pyrazol-5-yl-diazonium chloride malononitriie, and ethyl acetoacetate to afford pyrano[2,3-<em>c</em>]pyrazoles (4, 6)&nbsp;Pyra
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Elnagdi, Mohamed Hilmy, Ahmed Hafez Hussien Elghandour, Kamal Usef Sadek, and Mahmoud Mohamed Mahfouz Ramiz. "Studies on Condensed Pyrazoles. A New Route for Synthesis of Pyrazolo[4,3-c]pyrazoles." Zeitschrift für Naturforschung B 44, no. 8 (1989): 951–54. http://dx.doi.org/10.1515/znb-1989-0816.

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A novel synthesis of pyrazolo[4,3-c]pyrazoles via 1,5-dipolar cyclization of products of coupling of 2,3-dimethyl-1-phenyl-5-oxo-3-pyrazolin-4-diazonium chloride with active methylene reagents is reported.
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Chauhan, Pankaj, Suruchi Mahajan, and Dieter Enders. "Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives." Chemical Communications 51, no. 65 (2015): 12890–907. http://dx.doi.org/10.1039/c5cc04930j.

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The various catalytic asymmetric strategies employing organo- and metal-catalysts utilized pyrazolin-5-one derivatives for the synthesis of potentially bioactive enantiopure pyrazoles and pyrazolones are presented.
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Alsayari, Abdulrhman, Abdullatif Bin Muhsinah, Yahya I. Asiri, et al. "Arylhydrazono/Aryldiazenyl Pyrazoles: Green One-Pot Solvent-Free Synthesis and Anticancer Evaluation." Letters in Organic Chemistry 17, no. 10 (2020): 772–78. http://dx.doi.org/10.2174/1570178617666200320104923.

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The aim of this study was to synthesize and evaluate the biological activity of pyrazole derivatives, in particular, to perform a “greener” one-pot synthesis using a solvent-free method as an alternative strategy for synthesizing hydrazono/diazenyl-pyridine-pyrazole hybrid molecules with potential anticancer activity. Effective treatment for all types of cancers is still a long way in the future due to the severe adverse drug reactions and drug resistance associated with current drugs. Therefore, there is a pressing need to develop safer and more effective anticancer agents. In this context, s
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(MRS), B.D. SARAF, and N. WADODKAR K. "Synthesis of some New 5-(2-Hydroxyphenyl)-3-methyl-4-(1- acetyl-5-aryl-2-pyrazolin-3-yl)pyrazoles and 1-Phenyl-5- (2-hydroxyphenyl)-3-methyl-4-(1-phenyl-5-aryl-2- pyrazolin-3-yl)pyrazoles." Journal of Indian Chemical Society Vol. 70, Jul 1993 (1993): 643–44. https://doi.org/10.5281/zenodo.5917738.

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Department of Chemistry, Vidarbha Mahavidylaya, Amravati-444 604 <em>Manuscript received 4 October 1991, revised 19 January 1993, accepted 1 February </em>1993 synthesis of some New 5-(2-Hydroxyphenyl)-3-methyl-4-(1- acetyl-5-aryl-2-pyrazolin-3-yl)pyrazoles and 1-Phenyl-5-Synthesis of some New 5-(2-Hydroxyphenyl)-3-methyl-4-(1-(2-hydroxyphenyl)-3-methyl-4-(1-phenyl-5-aryl-2-pyrazolin-3-yl)pyrazoles &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;
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Queiroz, Jaqueline E., Lucas D. Dias, Giuliana M. Vila Verde, Gilberto L. B. Aquino, and Ademir J. Camargo. "An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained from Chalcone." Current Organic Chemistry 26, no. 2 (2022): 81–90. http://dx.doi.org/10.2174/1385272826666220119110347.

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Abstract: A review concerning the synthesis and pharmacological properties of pyrazoles obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented and discussed. Among the synthetic approaches for pyrazoles described so far, the cyclization and acetylation method of α,β-unsaturated chalcones, and substituted hydrazine were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, antimycobacterial, antiplasmodial, A
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Lindsay-Scott, Peter J., and Eloise Rivlin-Derrick. "Regiocontrolled Synthesis of 6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]oxazines." Synthesis 52, no. 01 (2019): 105–18. http://dx.doi.org/10.1055/s-0037-1610734.

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Synthetic access to 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazines has been achieved in 3–4 steps from commercially available pyrazoles. Optimization of a protected hydroxyethyl group on N1 enabled the regiocontrolled construction of pyrazole-5-aldehydes in high yields; subsequent deprotection and reduction generated fused heterocyclic scaffolds bearing multiple substitution patterns. Moreover, the intermediate pyrazole lactols were shown to be versatile synthetic building blocks.
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A., Rajeshwar Rao, Gopinath G., V. Madhuri J., and Satyanarayana S. "Synthesis of pyrazole and pyrazole amidocobaloximes." Journal of Indian Chemical Society Vol. 81, Jan 2004 (2004): 58–60. https://doi.org/10.5281/zenodo.5829945.

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Department of Chemistry, Osmania University, Hyderabad-500 007, India <em>E-mail</em> : ssnsirasani @yahoo.com <em>Manuscript received 23 September 2002, revised 23 April 2003. accepted 11 July 2003</em> A series of cyano (ligand) cobaloximes have been prepared where, the ligand is pyrazole (Pz), 1-(acetamido)pyrazole (Apz), 1-(<em>N</em>-methylacetamido)pyrazole (MAPz), 1-(acetamido)-3,5-dimethylpyrazole (MADMPz). The complex K[(CN)Co(D<sub>2</sub>H<sub>2</sub>)SCN] reacts with cthanolic solution of pyrazole or pyrazole amido ligands to form mixed ligand complexes. In all these complexes, the
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Lam, Linh, Sang H. Park, and Joseph Sloop. "Synthesis and Characterization of 3-Methyl-1-(4-(trifluoromethyl)phenyl)indeno [1,2-c]pyrazol-4(1H)-one." Molbank 2022, no. 4 (2022): M1483. http://dx.doi.org/10.3390/m1483.

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Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties. Herein, we report the acid-catalyzed synthesis of a new tricyclic, trifluoromethylated indenopyrazole, 3-methyl-1-(4-(trifluoromethyl)phenyl)indeno[1,2-c]pyrazol-4(1H)-one, from 2-acetyl-1,3-indanedione and 4-trifluoromethylphenylhydrazine. This isomeric pyrazole was obtained in yields ranging from 4–24%. NMR spectroscopic characterization and elemental ana
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Noori, Zahra, Miquel Solà, Clara Viñas, Francesc Teixidor, and Jordi Poater. "Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane." Beilstein Journal of Organic Chemistry 21 (February 21, 2025): 412–20. https://doi.org/10.3762/bjoc.21.29.

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A new series of o-carborane-fused pyrazoles has been recently successfully synthesized. This fusion was expected to create a hybrid 3D/2D aromatic system, combining the 3D aromaticity of o-carborane with the 2D aromaticity of pyrazole. However, while the boron cage retains its aromatic character, the pyrazole’s aromaticity is lost. As a result, rather than forming o-carborane-fused pyrazoles, the synthesis yielded o-carborane-fused pyrazolines, which are non-aromatic. The limited overlap between the π molecular orbitals (MOs) of the planar heterocycle and the n + 1 MOs of the carborane prevent
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Dissertations / Theses on the topic "Synthesis of Pyrazoles"

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Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr
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ERVITHAYASUPORN, VUTHICHAI. "Synthesis and Photochemistry of Pyrano[2,3-c]pyrazoles." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/228.

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Two different synthetic approaches to the synthesis of pyrano[2,3-c]pyrazoles have been investigated. In one approach, dehydroacetic acid derivatives were treated with phenylhydrazine and methylhydrazine led to the formation of the phenylhydrazones and methylhydrazones, which undergo rearrangement in refluxing acetic acid to diketo-phenylpyrazoles and diketo-methylpyrazoles. Upon treatment with a mixture of acetic and sulfuric acid these compounds isomerize to the phenylpyrano[2,3-c]pyrazol-4-one and methylpyrano[2,3-c]pyrazol-4-one derivatives. In a second approach, phenylhydrazine and methyl
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Ervithayasuporn, Vuthichai. "Synthesis and photochemistry of pyrano[2,3-c]pyrazoles." Link to electronic thesis, 2006. http://www.wpi.edu/Pubs/ETD/Available/etd-042006-160619/.

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Demirci, Deniz. "Synthesis Of 4-phenylselenyl-1h-pyrazoles By Electrophilic Cyclization." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613910/index.pdf.

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In this study, the synthesis of 5-ferrocenyl/aryl-4-(phenylselenyl)-1H-pyrazole derivatives was investigated since the integration of ferrocenyl and selenium moieties into pyrazole derivatives may increase their current biological activities. Initially, the starting propargyl aldehydes were synthesized from corresponding acetylenes. Subsequently, propargyl aldehydes were reacted with hydrazines to yield corresponding hydrazones. Then the in situ synthesized hydrazones were subjected to electrophilic cyclization with phenylselenyl chloride, which afforded 5-ferrocenyl/aryl-4-(phenylselenyl)-1H-
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Cooper, David Arthur. "The synthesis and characterization of some molybdenum, rhenium and rhodium complexes incorporating pyrazolylgallate ligands." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24597.

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Several uninegative ligands based on a gallium core and incorporating pyrazolyl groups have been synthesized and their metathesis reactions with molybdenum, rhenium and rhodium halides have been studied. The bidentate pyrazolylgallate ligand [formula omitted] has been incorporated in the complexes [formula omitted]. The unsymmetric tridentate pyrazolylgallate ligands [formula omitted] display a variable reactivity towards molybdenum, rhenium and rhodium precursors. Although no complexes incorporating L⁴ were isolated, L₂ and L₃ were shown to co-ordinate facially in the octahedral complexes
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Dunham, Jason C. "Synthesis of 4-alkyl-3,5-diamino-1-phenylpyrazoles." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339144.

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The goal of this project is to synthesize and purify a library of novel 4-alkyl-3,5-diamino-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazoles. These molecules are similar to other fiproles, which have been shown by Sammelson et al. to have pesticidal activities at the GABA receptor.' Fiproles are analogues of Fipronil, a very important pesticide. Replacing the cyano group normally located at the 3-position of the pyrazole ring with an amino group will change the binding potency of the phenylpyrazoles. Changes in binding produced by the changes introduced in molecular structure can create more
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Oleksik, Laurence. "Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/30087.

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Initially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported. The selective synthesis of a range of alpha-aryl vinyl ethers using Heck chemistry is then reported. Subsequent perfluoroacylations of the vinyl ethers followed by reaction of the resulting perfluoroacyl enol ethers with hydrazine affords a range of 5-aryl-3-perfluoroalkyl pyrazoles in good yields.;Alternative methodology for the synthesis of 5-aryl-3-perfluoroalkyl pyrazoles is then described
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Poulsen, Sally-Ann, and n/a. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors." Griffith University. School of Science, 1996. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050901.161632.

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Chapter 1 of thesis is a literature review of adenosine research. The central importance of the contributions of both classical pharmacology and, more recently, molecular biology to adenosine research is demonstrated. These disciplines have enabled the classification and characterisation of adenosine receptors and as well an understanding of the physiological significance of endogenous adenosine. The significant benefits of developing therapeutics for regulation of the diverse physiological functions of adenosine, by regulation of adenosine receptors, is outlined. For this therapeutic potentia
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Poulsen, Sally-Ann. "Pyrazolo(3,4-d)pyrimidines: Synthesis and Structure-Activity Relationships for Binding to Adenosine Receptors." Thesis, Griffith University, 1996. http://hdl.handle.net/10072/365893.

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Chapter 1 of thesis is a literature review of adenosine research. The central importance of the contributions of both classical pharmacology and, more recently, molecular biology to adenosine research is demonstrated. These disciplines have enabled the classification and characterisation of adenosine receptors and as well an understanding of the physiological significance of endogenous adenosine. The significant benefits of developing therapeutics for regulation of the diverse physiological functions of adenosine, by regulation of adenosine receptors, is outlined. For this therapeutic potentia
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Karabiyikoglu, Sedef. "Synthesis Of Ferrocenyl Substituted Pyrazoles By Sonogashira And Suzuki-miyaura Cross-coupling Reactions." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612139/index.pdf.

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Pyrazoles constitute one of the most important classes of heterocyclic compounds due to their interesting chemical and biochemical features. Researchers have studied many pyrazole containing structures for almost over a century in order to investigate the various biological activities possessed by these molecules. A new and important trend in these studies is to produce ferrocenyl substituted pyrazoles since ferrocene attracts considerable interest in the research field of organometallic and bioorganometallic chemistry because of its valuable chemical characteristics like high stability, low t
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Books on the topic "Synthesis of Pyrazoles"

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Aktoudianakis, Evangelos. Synthesis of annulated pyrazoles via a tandem alkylation/direct arylation sequence. 2006.

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Jadhav, Shravan Y., and Raghunath B. Bhosale. Pyrazole Chemistry Synthesis and Medicinal Applications. Lulu Press, Inc., 2017.

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Silva, Vera L. M., and Artur M. S. Silva, eds. Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-5421-1.

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Silva, Vera L. M., and Artur M. S. Silva, eds. Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds II. MDPI, 2023. http://dx.doi.org/10.3390/books978-3-0365-8790-5.

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Künkemeier-Schröder, Birgit. Heterocyclische mesomere Betaine als Strukturelemente für neuartige flüssigkristalline Verbindungen: Synthese monomerer und dimerer 1-Oxo-1H-pyrazolo[1,2-a]pyrazol-4-ium-3-olate. 1992.

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Evans, Wynne. The synthesis and properties of selected transition metal-pyrazole complexes and their applications towards homogeneous catalysis. 1991.

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Schnyder, Anita. Synthesis of pyrazole-containing ferrocenyl ligands and their application in the rhodium-catalyzed hydroboration of olefins. 1996.

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Roos, Franz Michael. Zum Reaktionsverhalten von Chlorpyridinen und zur Synthese mehrkerniger Triazepine aus Pyrazol-[beta]-Enaminoestern. 1992.

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Dörner, Manfred. Synthese von in 3-Stellung H-substituierten Pyrazolo-[5,1-d]-1,2,3,5-tetrazin-4(3H)-onen sowie deren Glycosylierung zu Nucleosiden. 1986.

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Drixler, Willi. Untersuchungen zur Bildung von N,1,2-Tris-(toluol-4-sulfonyl)-3-pyrazolidinimin aus 3-Amino-1-(toluol-4-sulfonyl)-2-pyrazolin: Synthese von 1-Arylsulfonyl-3-arylsulfonylamino-2-pyrazolinen. 1986.

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Book chapters on the topic "Synthesis of Pyrazoles"

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Gandhi, Divyani, Ayushi Sethiya, Nusrat Sahiba, Dinesh Kumar Jangid, and Shikha Agarwal. "Nanocatalysed Synthesis of Pyrazoles, Indazoles, and Pyrazolines." In Nanocatalysis. CRC Press, 2022. http://dx.doi.org/10.1201/9781003141488-10.

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Joule, J. A., K. Mills, and G. F. Smith. "1,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis." In Heterocyclic Chemistry. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-3222-8_22.

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Jachak, Madhukar N., Dilip R. Birari, Deepak P. Shelar, et al. "Regioselective Synthesis of Polyfluorinated Pyrazoles and Evaluation of Antimicrobial Activity." In Chemistry for Sustainable Development. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-90-481-8650-1_8.

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Li, Jie Jack. "Pechmann pyrazole synthesis." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_227.

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Li, Jie Jack. "Knorr pyrazole synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_148.

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Li, Jie Jack. "Pechmann pyrazole synthesis." In Name Reactions. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_216.

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Li, Jie Jack. "Knorr pyrazole synthesis." In Name Reactions. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_139.

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Li, Jie Jack. "Knorr Pyrazole Synthesis." In Name Reactions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50865-4_78.

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Yamamoto, S., T. Sato, K. Morimoto, and T. Nawamaki. "New Pyrazole Sulfonylureas." In Synthesis and Chemistry of Agrochemicals III. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch005.

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Jameson, Donald L., Ronald K. Castellano, Daniel L. Reger, James E. Collins, William B. Tolman, and Christopher J. Tokar. "Poly(1-Pyrazolyl)Alkane Ligands." In Inorganic Syntheses. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132630.ch8.

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Conference papers on the topic "Synthesis of Pyrazoles"

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Zanatta, Nilo, Marcio M. Lobo, Bruna Canova, Helio G. Bonacorso, and Marcos A. P. Martins. "Regioselective synthesis of 1,3- and 1,5-substituted pyrazoles and pyrazolynes analogous of Celecoxib." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20138818469.

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Medjahed, Nassima, Zahira Kibou, Amina Berrichi, Redouane Bachir, and Noureddine Choukchou-Braham. "Nickel-Catalyzed, One-Pot Synthesis of Pyrazoles." In International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2022. http://dx.doi.org/10.3390/ecsoc-26-13687.

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Koos, M., B. Steiner, and J. Gajdos. "Synthesis of Some Sulfur Bridged Pyrimidines, Pyrazoles and Imidazoles." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02002.

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Oumessaoud, Asmaa, Jamila Bouali, Salha Hamri, et al. "Efficient Synthesis of New Pyrazoles Derivatives via Functionalized Aryl-Sydnones." In 1st International Electronic Conference on Catalysis Sciences. MDPI, 2020. http://dx.doi.org/10.3390/eccs2020-07565.

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Yamini, G., M. Madhu Sekhar, G. Sravya, T. Sreenivasulu, A. Padmaja, and Grigory V. Zyryanov. "Green approach for the synthesis of some new diamidomethane linked pyridinyl pyrazoles." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087400.

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Трофимов, Б., B. Trofimov, Н. Гусарова, and N. Gusarova. "The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec92d17.

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New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor
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Navarini, Jussara, Helio G. Bonacorso, Carson W. Wiethan, et al. "Synthesis of New 5-Trifluoromethyl-3-alkyl[aryl(heteroaryl)]-4- (2-benzyl-3-hydroxycyclohex-2-enone-2-yl)-1H-pyrazoles by a Ring-Opening Reaction." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0009-1.

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Khatri, Taslimahemad Talab, Aadil Khursheed, and Pushpendra Kumar. "Water mediated synthesis of pyrano[2, 3-c]pyrazoles using L-histidine as an effective catalyst." In RECENT ADVANCES IN FUNDAMENTAL AND APPLIED SCIENCES: RAFAS2016. Author(s), 2017. http://dx.doi.org/10.1063/1.4990359.

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Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.

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The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Fi
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10

Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

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Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM
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Reports on the topic "Synthesis of Pyrazoles"

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Schmidt, R. D., G. S. Lee, P. F. Pagoria, A. R. Mitchell, and R. Gilardi. Synthesis and Properties of a New Explosive, 4-Amino-3,5-Dinitro-lH-Pyrazole (LLM-116). Office of Scientific and Technical Information (OSTI), 2001. http://dx.doi.org/10.2172/15005359.

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