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Relevant bibliographies by topics / Synthesis of quinoline

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Academic literature on the topic 'Synthesis of quinoline'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Synthesis of quinoline"

1

Shoji, Taku, Mutsumi Takeuchi, Mayumi Uda, et al. "Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes." Molecules 28, no. 15 (2023): 5785. http://dx.doi.org/10.3390/molecules28155785.

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Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which are readily prepared via the aromatic nucleophilic substitution reaction of a 2-chloroazulene derivative with several arylamines. The synthesis of azuleno[2,1-b]quinolones was established by the Brønsted acid-catalyzed intramolecular cyclization of 2-arylaminoazulene derivatives bearing two ester groups at the five-membered ring. The halogenat

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2

Horta, Pedro, Marta S. C. Henriques, Elisa M. Brás, et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate." Pure and Applied Chemistry 89, no. 6 (2017): 765–80. http://dx.doi.org/10.1515/pac-2016-1119.

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AbstractRecent studies directed to the design of compounds targeting the bc1 protein complex of Plasmodium falciparum, the parasite responsible for most lethal cases of malaria, identified quinolones (4-oxo-quinolines) with low nanomolar inhibitory activity against both the enzyme and infected erythrocytes. The 4-oxo-quinoline 3-ester chemotype emerged as a possible source of potent bc1 inhibitors, prompting us to expand the library of available analogs for SAR studies and subsequent lead optimization. We now report the synthesis and structural characterization of unexpected ethyl 6-methyl-7-i

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3

Xuan, Duc Dau. "Recent Progress in the Synthesis of Quinolines." Current Organic Synthesis 16, no. 5 (2019): 671–708. http://dx.doi.org/10.2174/1570179416666190719112423.

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Background: Quinoline-containing compounds present in both natural and synthetic products are an important class of heterocyclic compounds. Many of the substituted quinolines have been used in various areas including medicine as drugs. Compounds with quinoline skeleton possess a wide range of bioactivities such as antimalarial, anti-bacterial, anthelmintic, anticonvulsant, antiviral, anti-inflammatory, and analgesic activity. Due to such a wide range of applicability, the synthesis of quinoline derivatives has attracted a lot of attention of chemists to develop effective methods. Many known me

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4

Swapna, Sahu, Srivastava Shobhit, and Kumar Gupta Sujeet. "A Review on Quinoline: Diverse Pharmacological Agent." Chemistry Research Journal 6, no. 4 (2021): 81–96. https://doi.org/10.5281/zenodo.11666866.

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<strong>Abstract </strong>Quinoline is a heterocyclic aromatic organic & fused ring compound with the Chemical formula C<sub>9</sub>H<sub>7</sub>N.  Quinoline is an important pharmacophore in medicinal chemistry, since a large number of its derivatives possess useful biological properties. Also, Quinolones are known for their formation of conjugated molecules and polymers that combine enhanced electronic, optoelectronic, or nonlinear optical properties with excellent mechanical properties. They have a crucial role in the synthesis of various new therapeutic agents. For new drug develo

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5

Zhang, Xiaofeng, Miao Liu, Weiqi Qiu, and Wei Zhang. "2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives." Molecules 29, no. 6 (2024): 1241. http://dx.doi.org/10.3390/molecules29061241.

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Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists. This paper highlights 2-azidobenzaldehyde-based [4+2] annulation for the synthesis of quinoline derivatives including fused and spiro-quinolines, quinoline-4-ols, 4-aminoquinolines, and related compounds.

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6

Sonawane, Amol D., Dinesh R. Garud, Taro Udagawa, and Mamoru Koketsu. "Synthesis of thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivativesviaiodocyclization reaction and a DFT mechanistic study." Organic & Biomolecular Chemistry 16, no. 2 (2018): 245–55. http://dx.doi.org/10.1039/c7ob02523h.

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Thieno[2,3-b]quinoline and selenopheno[2,3-b]quinoline derivatives were synthesized by the regioselective iodocyclization reaction of 3-alkynyl-2-(methylthio)quinolines and 3-alkynyl-2-(methylseleno)quinolines.

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7

Srinivas, Sangu*and Anil Kumar Middha. "SYNTHESIS, ANTI MICROBIAL, ANTI CANCER EVALUTION AND MOLECULAR DOCKING STUDIES OF QUINAZOLINYL THIADIAZOLES DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11458–65. https://doi.org/10.5281/zenodo.1477785.

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<em>Quinazoline derivatives are reported to have anti microbial, anti inflammatory, analgesic and anti cancer activities. The incorporated oxymethyl carbamide at 4<sup>th</sup> position of the quinoline ring was found to influence the biological activities of the molecules with this some of new Quinolinyl- oxymethyl -thiadiazoles synthesized from 4-hydroxy quinoline through (quinolin-4yloxy) acetyl hydrazide intermediates. All the synthesized compounds were characterized by IR, H<sup>1</sup>NMR spectral data and carried out molecular docking studies against calcium/calmoduline dependent protei

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8

Parekh, H. P., M. H. Chauhan, N. L. Solanki, and V. H. Shah. "A Clean, Benign, Energy Efficient One-Pot Multicomponent Synthesis and Bio-evaluation of Novel [1,2,4]Triazolo[1,5-a]quinolines." Asian Journal of Organic & Medicinal Chemistry 6, no. 2 (2021): 111–15. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p322.

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In present work, a series of novel [1,2,4]triazolo[1,5-a]quinoline derivatives (HP-101-110) have been synthesized using multi-component reaction at room temperature in the presence of ammonium chloride as mild, cost effective green catalyst along with water as eco-friendly green solvent. The synthesis of 1,2,4-triazolo[1,5-a]quinolines (HP-101-110) was achieved by two step process. In first step, diversified Hantzsch pyridine reaction of an appropriate aromatic aldehyde, malononitrile, dimedone and benz hydrazide using ethanol as a solvent gives N-(2-amino-3-cyano-7,7-dimethyl-5-oxo-4-phenyl-5

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9

Singhal, Anchal, Pratibha Kumari, and Kharu Nisa. "Facile One-Pot Friedlander Synthesis of Functionalized Quinolines using Graphene Oxide Carbocatalyst." Current Organic Synthesis 16, no. 1 (2019): 154–59. http://dx.doi.org/10.2174/1570179415666181002114621.

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Background: Quinolines represent an important class of bioactive molecules which are present in various synthetic drugs, biologically active natural compounds and pharmaceuticals. Quinolines find their potential applications in various chemical and biomedical fields. Thereby, the demand for more efficient and simple methodologies for the synthesis of quinolines is growing rapidly. </P><P> Objective: The green one-pot Friedlander Synthesis of Functionalized Quinolines has been demonstrated by using graphene oxide as a carbocatalyst. </P><P> Method: The graphene oxide cat

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10

Bonyad, Ali Moin. "Synthesis of Chalcones from Acetone and tetrazole and 2-acetyl naphthalene Assisted by Microwave." Engineering and Technology Quarterly Reviews 3, no. 1 (2020): 16–22. https://doi.org/10.5281/zenodo.3686827.

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In the present study, we understood the total synthesis one chalcone derivative via Claisen-Schmidt condensation of the respective aldehydes and ketones using Microwave assisted irradiation method. In the microwave environment, chemical reactions usually proceed faster and give higher yields with fewer by- products. In the synthesis, a common aldehyde namely tetrazolo {1, 5-a} quinoline-4-carbaldehyde was used while the ketones used were respectively acetone, 2- acetyl Naphthalene. The Chalcone synthesised from Tetrazolo {1, 5-a} quinolone-4-carbaldehyde and acetone was 4-(tetrazolo {1, 5-a} q

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Dissertations / Theses on the topic "Synthesis of quinoline"

1

Barr, Stephen Alexander. "Quinoline alkaloids : synthesis and stereochemistry." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333796.

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2

Klaas, Phindile Jonathan. "Novel approaches to the synthesis of quinoline derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004751.

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The investigation has been concerned with the application of the Baylis-Hillman methodology to the synthesis of quinoline derivatives. An extensive range of novel Baylis-Hillman products has been prepared, typically in moderate to excellent yields, by condensing 2-nitrobenzaldehyde derivatives with various vinyl ketones and acrylic esters in the presence of diazabicyclo[2.2.2]octane (DABCO). Reduction of the nitro group in the Baylis-Hillman products was effected by catalytic hydrogenation in ethanol using a 10% palladium-on-carbon catalyst to afford quinoline, quinoline-N-oxide and quinolone

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3

Neville, Charles Frederick. "The synthesis and biosynthesis of quinoline alkaloids." Thesis, University of Ulster, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481119.

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4

Velioglu, Ozlem. "Synthesis Of Ferrocenyl Substituted Quinolines." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609785/index.pdf.

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Quinolines have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of quinolines with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted quinolines, such as 2-ferrocenylquinoline, by

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5

Haddad, Jalal. "Synthesis and chemistry of some quinoline-5,8-diones." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/917048.

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The synthesis of several 7-substituted analogs of 2-methylquinoline-5,8-dione and their chemistry are described. In this investigation the following compounds were prepared.5,7-Diformamido-8-hydroxy-2-methylquinoline (207), 7-formamido-2methylquinoline-5,8-dione (199), 7-acetamido-2-methylquinoline-5,8-dione (6), 7-isobutyramido-2-methylquinoline-5,8-dione (200), 7-amino-2-methylquinoline-5,8-dione (210), 7-amino-6-chloro-2-methylquinoline-5,8-dione (213), 7-methoxy-2-methylquinoline5,8-dione (214), 7-ethoxy-2-methylquinoline-5,8-dione (215), 7-isopropyloxy-2methylquinoline-5,8-dione (216), 7-

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6

Watters, William Henry. "Studies towards the synthesis of hemiterpenoid quinoline alkaloids." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241684.

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7

Mazzanti, Stefano. "A novel atroposelective strategy for the synthesis of quinoline substrates." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16660/.

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Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of new pharmacological active compounds. Since the discovery of their antimalarial properties, a large variety of quinolines was found to have interesting physiological activities and displayed attractive applications for pharmaceutical industries. In accordance to the above-mentioned features, a number of methods were developed for their synthesis but enantioselective versions are still lacking in the literature. In the past decades, this question has become even more complex, with the emergenc

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8

Hamilton, Lynne. "Synthesis, stereochemistry and reactions of quinoline, isoquinoline and acridine metabolites." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334710.

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9

Loke, P. L. "Chemoenzymatic and chemical synthesis of enantiopure quinoline derivatives and alkaloids." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273295.

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10

Rahman, Adrian. "The synthesis of new tricyclic beta lactams based upon quinoline." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366356.

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Books on the topic "Synthesis of quinoline"

1

Neville, Charles Frederick. The synthesis and biosynthesis of quinoline alkaloids. The Author], 1989.

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2

Greer, Robert James. Studies in the synthesis of quinoline alkaloids. The Author), 1987.

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3

Ronne, Erik. Synthesis of imidazoazaarenes. Swedish University of Agricultural Sciences, Dept. of Chemistry, 1994.

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4

Roberts, David. The synthesis of 1,3,4,5-terahydropyrrolo[4,3,2-de]quinolines. University of Manchester, 1994.

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5

Roberts, David. The synthesis of pyrrolo[4,3,2-de]quinolines and approaches towards hinckdentine A and apparacine. University of Manchester, 1996.

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6

IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some naturally occurring and synthetic food components, furocoumarins, and ultraviolet radiation. World Health Organization, International Agency for Research on Cancer, 1986.

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7

Jokela, Reija. Indolo(2.3-a)quinolizine and n-methylpiperidine derivatives: Synthetic methods and stereochemical considerations. Suomalainen Tiedeakatemia, 1985.

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8

Erickson, W. Randal. Studies on advanced intermediates in the biosynthesis of streptonigrin. 1987.

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9

Singh, Rajesh Kumar, ed. Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150400741220101.

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This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decis

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10

Hewitt, J. T. Synthetic Colouring Matters Dyestuffs Derived from Pyridine, Quinoline, Acridine and Xanthene. Creative Media Partners, LLC, 2022.

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Book chapters on the topic "Synthesis of quinoline"

1

Li, Jie Jack. "Pfitzinger quinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_232.

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Li, Jie Jack. "Skraup quinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_278.

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Li, Jie Jack. "Combes quinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_64.

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4

Li, Jie Jack. "Friedländer quinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_110.

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Li, Jie Jack. "Skraup quinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_254.

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6

Li, Jie Jack. "Camps quinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_50.

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Li, Jie Jack. "Combes quinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_65.

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Li, Jie Jack. "Doebner quinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_90.

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Li, Jie Jack. "Pfitzinger quinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_221.

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Li, Jie Jack. "Skraup quinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_266.

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Conference papers on the topic "Synthesis of quinoline"

1

Mangalagiu, Violeta, Dumitrela Diaconu, and Ionel Mangalagiu. "Quinoline - sulfonamide - complexes with antimicrobial activity." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab26.

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Quinoline-sulfonamide-complexes with variously metals, especially M2+, are a relatively new class of compounds with potential practical interest as fluorescent materials (having fotoluminiscent properties) and also as drugs (having a large variety of biological activities such as antibacterial, antifungal, antiprotozoals, etc.). The emphasis of this work was to obtain hybrid quinoline – sulfonamide - complexes with antimicrobial activity. The synthesis of the hybrid derivatives is direct and efficient, in two steps: acylation of variously amino-quinoline followed by metal complexation with dif

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2

Barbosa, Luiz C. A., Carmindo R. Borel, Sergio A. Fernandes, and Célia R. A. Maltha. "Povarov reaction for the synthesis of 2-(2-pyridyl)quinoline." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013816161848.

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Diaconu, Dumitrela, Violeta Mangalagiu, Dorina Amariucai-Mantu, Vasilichia Antoci, and Ionel Mangalagiu. "SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.45.

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Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combination we have decided to combine the two pharmacophore fragments. And at last, th

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Rahatgaonkar, Anjali Milind. "Synthesis of Chitosan-Quinoline Biocomposites for Solvent Extraction Applications." In SAE 2010 World Congress & Exhibition. SAE International, 2010. http://dx.doi.org/10.4271/2010-01-0429.

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Zbancioc, Gheorghita, Costel Moldoveanu, and Ionel I. Mangalagiu. "Syntheses of new benzoquinoline derivatives with anticancer activity." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.92.

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This work synthesized various novel benzo[c]quinoline compounds, detailed their structural features, and examined their anticancer activity in vitro. First, the nitrogen atom in benzo[c]quinoline is quaternized, and the in situ-formed ylide is then subjected to a [3+2] dipolar cycloaddition reaction. A detailed investigation was conducted to determine how successful traditional thermal heating (TH) synthesis was in comparison to microwave (MW) and ultrasonic (US) irradiation. FTIR, HRMS, and NMR were the three spectral techniques that were used to prove the structure of all the obtained compou

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Saraiva, Maiara, Roberta Krüger та Diego Alves. "Synthesis of Quinoline-Triazoil Carboxylates by Organocatalytic Cycloaddition of β-Ketoesters and 4-Azido-7-Chloroquinoline". У 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013811191913.

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Ahsan, Mohamed Jawed, Rita Yadav, and Surender Jadav. "Synthesis, Anticancer Activity and Molecular Docking Studies of Newer Quinoline Analogues." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a033.

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Sousa, Rui P. C. L., Susana P. G. Costa, Rita B. Figueira, and M. Manuela M. Raposo. "Quinoline-Based Hydrazone Derivative as a Biocide Chemosensor: Synthesis and Sensing Studies." In ECSA-9. MDPI, 2022. http://dx.doi.org/10.3390/ecsa-9-13199.

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Laumaillé, Pierre, Alexandra Dassonville-Klimpt, Sophie Da Nascimento, et al. "Synthesis, biological evaluation and membranotropic properties of quinoline-antimicrobial peptide conjugates as antibacterial drugs." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06320.

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Humeedi, Mohammed Dahham, and Maha Salih Hussein. "Synthesis new derivatives of quinoline and study the biological activity for some of them." In International Conference of Chemistry and Petrochemical Techniques (ICCPT). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0093611.

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Reports on the topic "Synthesis of quinoline"

1

Bradshaw, Jerald S., Guoping Xue, Xian X. Zhang, Paul B. Savage, and Krzysztof E. Krakowiak. Bis-(quinolin-8-ylmethyl)-substituted Diaza-18-crown-6: Synthesis and Metal Ion Complexation Properties. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada375274.

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