Academic literature on the topic 'Synthesis of thiosemicarbazone'

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Journal articles on the topic "Synthesis of thiosemicarbazone"

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Hernández, Wilfredo, Fernando Carrasco, Abraham Vaisberg, et al. "Synthesis, Spectroscopic Characterization, Structural Studies, and In Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives." Journal of Chemistry 2020 (September 14, 2020): 1–12. http://dx.doi.org/10.1155/2020/2960165.

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Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4′-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone (3), 2-chloro-5-bromo-pyridine-3-carbaldehyde thiosemicarbazone (4), 6-(3′,4′-dimethoxyphenyl)pyridine-3-carbaldehyde thiosemicarbazone (5), 2-chloro-5-fluor-pyridine-3-carbaldehyde thiosemicarbazone, (6), 5-iodo-pyridine-3-carbaldehyde thiosemicarbazone (7), and 6-(3′,5′-dichlorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (8) were synthesized, from the reaction of t
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Nagoor Meeran M and Narayanan Ravisankar. "Synthesis and characterization of substituted acetophenone-4, 4-dimethyl-3-thiosemicarbazone derivatives with an evaluation of antimicrobial and antioxidant activities." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 7192–97. http://dx.doi.org/10.26452/ijrps.v11i4.3844.

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Thiosemicarbazones are organic compounds; these are widely used in the medical field. It is primarily in the manufacture of pharmaceutical drugs and bio molecules. These compounds have the azomethine functional group (-N=CH-) used to derive organic open chain and heterocyclic compounds. Thiosemicarbazones are similar to semicarbazones, and carbonyl group oxygen is replaced by sulphur. Thiosemicarbazone contains nitrogen and sulfur atoms, so they are used as ligands in coordination chemistry and form metal complexes. Thiosemicarbazone and its metal complexes are used in a variety of ways. It is
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Muthukumar, Manisekar, and Periasamy Viswanathamurthi. "Synthesis, spectral characterization and catalytic studies of new ruthenium(II) chalcone thiosemicarbazone complexes." Open Chemistry 8, no. 1 (2010): 229–40. http://dx.doi.org/10.2478/s11532-009-0116-x.

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AbstractA series of new hexa-coordinated ruthenium(II) complexes of the type [Ru(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = chalcone thiosemicarbazone) have been prepared by reacting [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py) with chalcone thiosemicarbazones in benzene under reflux. The new complexes have been characterized by analytical and spectroscopic (IR, UV-vis, 1H, 31P and 13C NMR) methods. On the basis of data obtained, an octahedral structure was assigned for all of the complexes. The chalcone thiosemicarbazones behave as dianionic tridentate O, N, S don
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Santos, Felipe R. S., Jéssica T. Andrade, Carla D. F. Sousa, et al. "Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones." Medicinal Chemistry 15, no. 1 (2019): 38–50. http://dx.doi.org/10.2174/1573406414666180730111954.

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Background: Microbial infections is a global public health problem. The aim of this work was to synthesize and evaluate the antimicrobial activity of novel triazoles, morpholines and thiosemicarbazones. </P><P> Methods: Compounds were synthesized using 2,4-Dihydroxyacetophenone and 4-hydroxybenzaldehyde as starting materials. The antimicrobial activity of these compounds against bacteria and yeast was evaluated by the broth microdilution method. Results: The proposed route for synthesis gave high to moderate yields, moreover these compounds were successfully characterized by 1H NMR
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Khan, Salman A., Abdullah M. Asiri, Khalid Al-Amry, and Maqsood Ahmad Malik. "Synthesis, Characterization, Electrochemical Studies, andIn VitroAntibacterial Activity of Novel Thiosemicarbazone and Its Cu(II), Ni(II), and Co(II) Complexes." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/592375.

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Metal complexes were prepared by the reaction of thiosemicarbazone with CuCl2, NiCl2, CoCl2, Cu(OAc)2, Ni(OAc)2, and Co(OAc)2. The thiosemicarbazone coordinates to metal through the thionic sulfur and the azomethine nitrogen. The thiosemicarbazone was obtained by the thiosemicarbazide with 3-acetyl-2,5-dimethylthiophene. The identities of these compounds were elucidated by IR,1H,13C-NMR, and GC-MS spectroscopic methods and elemental analyses. The antibacterial activity of these compounds was first testedin vitroby the disc diffusion assay against two Gram-positive and two Gram-negative bacteri
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Cobeljic, Bozidar, Marijana Zivkovic, Ivana Matic, et al. "Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones." Journal of the Serbian Chemical Society, no. 00 (2020): 83. http://dx.doi.org/10.2298/jsc201211083c.

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In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D NMR and 2D NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that new steroidal thiosemicarbazone complexes were significantly less cytotoxic than
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Agarwal, Ram K., and Surendra Prasad. "Synthesis, Spectroscopic and Physicochemical Characterization and Biological Activity of Co(II) and Ni(II) Coordination Compounds with 4-Aminoantipyrine Thiosemicarbazone." Bioinorganic Chemistry and Applications 3, no. 3-4 (2005): 271–88. http://dx.doi.org/10.1155/bca.2005.271.

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We describe the synthesis and characterization of cobalt(II) and nickel(II) coordination compounds of 4[N-(furan-2’-aldimine)amino]antipyrine thiosemicarbazone (FFAAPTS) and 4[N-(4'-nitrobenzalidene) amino]antipyrine thiosemicarbazone (4'-NO2BAAPTS). All the isolated compounds have the general composition MX2(L)(H2O) (M = Co2+or Ni2+; X = Cl, Br, NO3, NCS or CH3COO; L = FFAAPTS or 4'-NO2BAAPTS) and M(ClO4)2(L)2(M = Co2+or Ni2+; L = FFAAPTS or 4'-NO2BAAPTS). Infrared spectral studies indicate that both the thiosemicarbazones coordinate in their neutral form and they act as {N,N,S} tridentate ch
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Huang, Yanmin, Erbin Kong, Chunfang Gan, Zhiping Liu, Qifu Lin, and Jianguo Cui. "Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes." Bioinorganic Chemistry and Applications 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/742592.

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Steroidal compounds exhibit particular physiological activities. In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting materials and complexation of steroidal thiosesemicarbazones with Pt(II). The complexes were characterized by IR, NMR, and MS, and their antiproliferative activities were evaluated. The results showed that some steroidal thiosemicarbazones platinum (Pt(II)) complexes displayed moderate cytotoxicity to H
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Wakodkar, Rohit R., Mazahar Farooqui, Pravin Kulkarni, and Deepak D. Kayande. "Synthesis and Biological Activity of Some Thiosemicarbazide." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 228–31. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p206.

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In this paper, thiosemicarbazone derivatives have been prepared from substituted aromatic aldehyde and thiosemicarbazide in presence of sodium chloride. This method is an efficient, mild, inexpensive, non-toxic and environment benign catalyst. This protocol includes the reaction followed by using sodium chloride to accelerate the reaction in aqueous ethanol. The structure of synthesized compounds were determined by IR, 1H NMR, 13C NMR and mass spectroscopies as well as the compounds were also screened for antibacterial and antifungal activity against certain Gram-negative and Gram-positive bac
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Shehzad, Muhammad Tariq, Ajmal Khan, Sobia Ahsan Halim, et al. "Synthesis of indole-substituted thiosemicarbazones as an aldose reductase inhibitor: an in vitro, selectivity and in silico study." Future Medicinal Chemistry 13, no. 14 (2021): 1185–201. http://dx.doi.org/10.4155/fmc-2020-0060.

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Aim: Indole is an important component of many drug molecules, and its conjugation with thiosemicarbazone moiety would be advantageous in finding lead compounds for the development of diabetic complications. Methodology: We have designed, synthesized and evaluated a series of 17 indole-thiosemicarbazones (3a–q) as aldose reductase (ALR2) and aldehyde reductase (ALR1) inhibitors. Results: After in vitro evaluation, all indole-thiosemicarbazones showed significant inhibition against both enzyme ALR1 and ALR2 with IC50 in range of 0.42–20.7 and 1.02–19.1 μM, respectively. The docking study was als
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Dissertations / Theses on the topic "Synthesis of thiosemicarbazone"

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Khanye, Setshaba David. "Synthesis and Antimalarial evaluation of Gold Thiosemicarbazone Complexes and Polyamine-Thiosemicarbazone Dendrimers." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/6317.

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Malaria still remains one of the most dangerous widespread parasitic diseases in developing nations. Reported alarming figures of malaria infections annually highlight the âgapâ that remains to be filled to rid endemic of malaria. As cases of increasing spread of malaria and the emergence of resistance continue to exert pressure on health systems in most affected areas, novel antimalarial compounds are endlessly needed to overcome the problem of malaria infections. This thesis presents research investigating a series of thiosemicarbazones (TSCs) and their novel gold complexes and dendrimers as
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Morrison, E. C. "Synthesis and reactions of organo-metal thiosemicarbazone complexes and closely related compounds." Thesis, University of Greenwich, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378049.

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Bordbar, Hadi. "Synthesis of thiosemicarbazone-based and 3,5-dibromo-4-hydroxyphenyl ketone compounds as potential non-steroidal inhibitors of the enzyme estrone sulfatase." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22973/.

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Estrone sulfatase (STS) has been shown to play a major role in the biosynthesis of estrogens [in particular estrone (E 1) which subsequently leads to the biosynthesis of estradiol (E2)] and therefore the initiation and progression of hormone-dependent breast cancer in post menopausal women. Recently, a range of thiosemicarbazone-based compounds have been reported as inhibitors of STS, however, due to the mode of action of these inhibitors, no detailed structure-activity relationship (SAR) was offered. In an effort to investigate the SAR within the thiosemicarbazone-based compounds, the current
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Sonja, Ivković. "Novi kompleksi nekih 3d metala sa semi-, tiosemi- i S-metilizotiosemikarbazonom piridoksala." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=85689&source=NDLTD&language=en.

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Opisane su sinteze, fizičko-hemijske i strukturne karakteristike kompleksa Cu(II), Co(II), Co(III), Ni(II), Fe(III), Cr(III) Zn(II) i Cd(II) sa PLSC, PLTSC i PLITSC. Dobijene su dve nove protonovane forme liganda PLSC, kao i od ranije poznati neutralna forma PLSC i protonovana forma PLTSC ali u vidu monokristala pogodnih za rentgeno-strukturnu analizu i 37 kompleksa, od čega je 12 okarakterisano rentgeno-strukturnom analizom. U zavisnosti od pH sva tri liganda se mogu koordinovati kao neutralni, mono-, odnosno, dianjoni sa uobičajenim ONO, ONS i ONN setom donorskih atoma, respektivno, pri čemu
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Stringer, Tameryn. "Multinuclear PGM complexes of thiosemicarbazones : synthesis, characterisation and biological activity." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11409.

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Includes abstract.<br>Includes bibliographical references.<br>A series of mono- and dithiosemicarbazone ligands were prepared by simple Schiff-base condensation reactions between thiosemicarbazides and various substituted salicylaldehydes.
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Adams, Muneebah. "Mono- and multinuclear PGM complexes containing thiosemicarbazones synthesis, characterization and antiplasmodial evaluation." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10907.

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Four aryl- and ferrocenyl-derived thiosemicarbazone ligands have been synthesized and characterized using NMR, infrared (IR) spectroscopy and mass spectrometry. These ligands were used towards the synthesis of three series of mono- and multinuclear complexes, in which the thiosemicarbazone ligands chelate in either a bidentate (N,S) or tridentate (C,N,S) mode.
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Alther, Andreas Markus. "Synthese und analytische Untersuchung von o-substituierten Benzaldehydsemi- und -thiosemicarbazonen und deren Platin(II)-Komplexen /." [S.l.] : [s.n.], 1986. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8090.

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SILVA, RENATA SOBRAL. "MN(II) AND CO(II) COMPLEXES WITH THIOSEMICARBAZONES AND FLUORQUINOLONES: SYNTHESIS, SPECTROSCOPIC AND ELECTROCHEMICAL STUDIES AND BIOLOGICAL ACTIVITY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2009. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=14131@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Tiossemicarbazonas e fluorquinolonas são compostos que apresentam uma grande diversidade de aplicações farmacológicas. Este trabalho compreende um estudo de tiossemicarbazonas e seus complexos de Mn(II) e Co(II) com potencial ação antiparasitária e antitumoral e de complexos de Mn(II) e Co(II) de fluorquinolonas com atividade antimicrobiana. N(4)-metil tiossemicarbazonas derivadas de 4-nitrobenzaldeído (H4NO2Fo4M)
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De, Klerk Colette. "The synthesis of 4-methyl-3-thiosemicarbazide (MTSC) using N,N-diisopropylethylamine as base / Colette de Klerk." Thesis, Potchefstroom University for Christian Higher Education, 1999. http://hdl.handle.net/10394/9609.

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4-Methyl-3-thiosemicarbazide (MTSC) is an intermediate for the synthesis of 5-t-butyl-2-methylamino-1,3,4-thiadiazole (BTDA), the precursor of tebuthiuron, a broad-spectrum herbicide. The current production process for MTSC being used at Sanachem's Devchem plant in Sasolburg entails the hydrazinolysis of ammonium N-methyldithiocarbamate. This method affords only a 60-65% yield of MTSC with purity of only 93-94%, while the manufacturing of BTDA of high purity (>98%) and yield requires MTSC of good quality (>97%). The current method also generates approximately 4kg of effluent for each kilogram
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Siles, Rogelio Pinney Kevin G. "Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/3018.

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Book chapters on the topic "Synthesis of thiosemicarbazone"

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Pitha, John J., John P. Olatta, Eugene Lieber, S. H. Patinkin, and R. D. Pratt. "Thiosemicarbazide." In Inorganic Syntheses. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132357.ch12.

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Kovala-Demertzi, Dimitra, Asimina Domopoulou, and Mavroudis A. Demertzis. "Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone." In Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5780-3_29.

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Lieber, Eugene, C. N. Pillai, Edwin Oftedahl, Ralph D. Hites, and J. A. Chandler. "The Diazotization of Thiosemicarbazide and 4-Alkyl and 4-Aryl Thiosemicarbazides." In Inorganic Syntheses. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132371.ch13.

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Swathi, Konda, Galla Rajitha, and Manda Sarangapani. "Synthesis and Characterization of Biologically Significant 5-[N,N-dialkylamino alkoxy] azaindole 2-one, 3-thiosemicarbazones and 5-[N,N-dialkylamino alkoxy] azaindole 3-hydrazone, 2-ones." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-32633-3_27.

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Pham, Van Hien, Thi Phuong Dung Phan, Dinh Chau Phan, and Binh Duong Vu. "Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons." In Prime Archives in Molecular Sciences. Vide Leaf, Hyderabad, 2021. http://dx.doi.org/10.37247/pamol2ed.2.2021.30.

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Zou, H. "Synthesis and structural characterization of a new Ca (II) complex with 2-Formyl-benzenesulfonate-thiosemicarbazide ligand." In Material Science and Environmental Engineering. CRC Press, 2015. http://dx.doi.org/10.1201/b19346-48.

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Conference papers on the topic "Synthesis of thiosemicarbazone"

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Tadjarodi, Azadeh, and Homayoun Gholipour. "Synthesis and characterization of 4-pyridinecarboxaldehyde thiosemicarbazone." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-a030.

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Rúa-Sueiro, Marcos, Paula Munin-Cruz, Francisco Reigosa, José M. Vila, and M. Teresa Pereira. "Synthesis and characterization of novel thiosemicarbazone palladacycles." In The 23rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecsoc-23-06494.

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Sampath, K., and S. Krithika. "Synthesis, characterization and NLO property of ruthenium(II) thiosemicarbazone complexes." In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS: ICAM 2019. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5130328.

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Carballido, Rocío, Rosa Pedrido, Manuel Bermejo, Esther Gómez-Fórneas, and Marcelino Maneiro. "Synthesis and X-ray Crystal Structure of the Thiosemicarbazone Lbis(4-N-Methyl-Thiosemicarbazone)-4,4'-Diacetylphenylmethane." In The 18th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-d001.

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Tadjarodi, Azadeh, and Homayoun Gholipour. "Microwave-assisted synthesis of Cd (II) complex of 4-pyridinecarboxaldehyde thiosemicarbazone." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-c007.

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Rúa-Sueiro, Marcos, Paula Munin-Cruz, Francisco Reigosa, José M. Vila, and Juan M. Ortigueira. "Synthesis and X-ray diffraction study of thiosemicarbazone palladacycles with dppm." In The 2nd International Online Conference on Crystals. MDPI, 2020. http://dx.doi.org/10.3390/iocc_2020-07352.

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Lucio Martinez, Fatima, Jose M. Vila, Francisco Reigosa, Paula Munín, Juan Manuel Ortigueira, and Mª Teresa Pereira. "Synthesis and reactivity of a new type of crown ether thiosemicarbazone." In The 22nd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecsoc-22-05686.

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Nimir, Hassan, Norah Al Mohaideb, Mariem Hamad, et al. "Synthesis, Characterization, Crystal Structures, and in vitro Antitumor Activity of Palladium and Platinum (Ii) Complexes with 2-Acetyl-4-Methylthiazole Thiosemicarbazone and 2-Acetylpyrazine Thiosemicarbazone." In Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2016. http://dx.doi.org/10.5339/qfarc.2016.hbpp3347.

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Reddy, A. Sreenath, L. Sivarama Krishna, Vishnu Nayak Badavath, G. Sravya, N. Bakthavatchala Reddy, and Grigory V. Zyryanov. "Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087386.

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Reigosa Chamorro, Francisco, Fátima Lucio, Adolfo Fernández-Figueiras, et al. "Functionalized thiosemicarbazone ligands and their complexes." In The 20th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a041.

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