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Journal articles on the topic 'Synthesis. piperidines. combinatorial chemistry techniques'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Keifer, Paul A. "High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry." Drug Discovery Today 2, no. 11 (1997): 468–78. http://dx.doi.org/10.1016/s1359-6446(97)01104-5.

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2

Jennings, Lee D., Kenneth W. Foreman, Thomas S. Rush, et al. "Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction." Bioorganic & Medicinal Chemistry 12, no. 19 (2004): 5115–31. http://dx.doi.org/10.1016/j.bmc.2004.07.031.

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3

KEIFER, P. A. "ChemInform Abstract: High-Resolution NMR Techniques for Solid-Phase Synthesis and Combinatorial Chemistry." ChemInform 29, no. 8 (2010): no. http://dx.doi.org/10.1002/chin.199808300.

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4

Takeuchi, Ichiro, Robert Bruce van Dover, and Hideomi Koinuma. "Combinatorial Synthesis and Evaluation of Functional Inorganic Materials Using Thin-Film Techniques." MRS Bulletin 27, no. 4 (2002): 301–8. http://dx.doi.org/10.1557/mrs2002.97.

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AbstractNovel phases of functional inorganic chemical systems can be efficiently explored using high-throughput thin-film fabrication techniques coupled with rapid characterization schemes. High-throughput investigation of thin-film materials has already led to the discovery of new dielectric and magnetic materials. In this article, we review various high-throughput thin-film synthesis/evaluation techniques and discuss examples of exciting discoveries and new applications of combinatorial techniques.

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Schumacher, Elaine F., and Rune Wendelbo. "Automated Imaging of Combinatorial Chemistry Synthesis Arrays in a Large Chamber Low Vacuum SEM." Microscopy and Microanalysis 7, S2 (2001): 1076–77. http://dx.doi.org/10.1017/s1431927600031457.

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In combinatorial chemistry, miniaturization and automation are used to carry out many experiments in a simultaneous array, as opposed to doing single experiments in sequence. This high throughput approach is widely used in the drug industry, and is now finding application in the development of novel materials for catalysis. Successful implementation of combinatorial methodology to speed discovery and commercialization of new materials requires that these techniques be applied to every step of the experimental process, from combination of reagents for synthesis through characterization and perf

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Matsumoto, Y., H. Koinuma, T. Hasegawa, I. Takeuchi, F. Tsui, and Young K. Yoo. "Combinatorial Investigation of Spintronic Materials." MRS Bulletin 28, no. 10 (2003): 734–39. http://dx.doi.org/10.1557/mrs2003.215.

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AbstractHigh-throughput synthesis and characterization techniques have been effective in discovering new materials and performing rapid mapping of phase diagrams. The application of the combinatorial strategy to explore doped transition-metal oxides has led to the discovery of a transparent room-temperature ferromagnetic oxide in Co-doped anatase TiO2. The discovery has triggered a wave of studies into other metal oxide systems in pursuit of diluted magnetic semiconductors. In this article, we describe recent combinatorial studies of magnetic transition-metal oxides, germanium-based magnetic s

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Prasad, Virendra, Nidhi Mishra, Anand K. Agrahari, Sumit K. Singh, Prabhu P. Mohapatra, and Vinod K. Tiwari. "Cycloelimination-assisted Combinatorial Synthesis of Diverse Heterocyclic Scaffolds of Chemotherapeutic Values." Current Organic Chemistry 23, no. 7 (2019): 768–808. http://dx.doi.org/10.2174/1385272823666190405145805.

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Recent advances in high-throughput, automated techniques combined with the identification of new therapeutic targets in genome sequencing and molecular biology have generated a need for a large collection of diverse heterocyclic scaffolds. This inspires toward the development of novel reaction sequences and linking strategies to generate libraries of diverse simple to complex heterocyclic systems. In this regard, combinatorial chemistry has emerged as an excellent technology platform for the rapid assembly of building blocks to synthesize complex molecular structures with great ease in a few s

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Niedbała, Patryk, and Janusz Jurczak. "One-Pot Parallel Synthesis of Unclosed Cryptands—Searching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques." ACS Omega 5, no. 40 (2020): 26271–77. http://dx.doi.org/10.1021/acsomega.0c04228.

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Sun, Ted X., and G. E. Jabbour. "Combinatorial Screening and Optimization of Luminescent Materials and Organic Light-Emitting Devices." MRS Bulletin 27, no. 4 (2002): 309–15. http://dx.doi.org/10.1557/mrs2002.98.

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AbstractThe rapid development of modern photonic technologies—for example, mercury-free lamps, flat-panel displays, and solid-state lamps—demands the timely discovery of advanced phosphors. A combinatorial process has been developed to dramatically accelerate the experimental search for such phosphors. High-density phosphor “libraries” containing from 100 to over 1000 discrete chemical compositions on a 1 in. × 1 in. substrate have been made in thin-film or powder form using selective vapor deposition and liquid-dispensing techniques, respectively. In this article, the existing methods of comb

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10

Jennings, Lee D., Kenneth W. Foreman, Thomas S. Rush, et al. "Corrigendum to “Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction” [Bioorg. Med. Chem. 12 (2004) 5115–5131]." Bioorganic & Medicinal Chemistry 13, no. 20 (2005): 5884. http://dx.doi.org/10.1016/j.bmc.2005.08.001.

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11

Carlton, Robert A., Edward Orton, Charles E. Lyman, and James E. Roberts. "Qualitative Analysis of Solid Phase Synthesis Reaction Products by X-ray Spectrometry." Microscopy and Microanalysis 3, no. 6 (1997): 520–29. http://dx.doi.org/10.1017/s1431927697970409.

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Abstract: A novel method for the synthesis of polypeptides using polystyrene/divinylbenzene copolymers as solid supports has drawn the attention of medicinal, pharmaceutical, and agricultural chemists because of its utility in combinatorial chemistry and parallel synthesis. In this method, arrays of solid-phase organic synthesis experiments are conducted simultaneously thereby enabling the preparation of large numbers of novel compounds over a short time period. The analysis of organic compounds attached to polymer supports presents unique challenges to chemists. This study presents some resul

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12

Kayser, Oliver. "Ethnobotany and Medicinal Plant Biotechnology: From Tradition to Modern Aspects of Drug Development." Planta Medica 84, no. 12/13 (2018): 834–38. http://dx.doi.org/10.1055/a-0631-3876.

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AbstractSecondary natural products from plants are important drug leads for the development of new drug candidates for rational clinical therapy and exhibit a variety of biological activities in experimental pharmacology and serve as structural template in medicinal chemistry. The exploration of plants and discovery of natural compounds based on ethnopharmacology in combination with high sophisticated analytics is still today an important drug discovery to characterize and validate potential leads. Due to structural complexity, low abundance in biological material, and high costs in chemical s

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13

Kumar Kulabhusan, Prabir, Babar Hussain, and Meral Yüce. "Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents." Pharmaceutics 12, no. 7 (2020): 646. http://dx.doi.org/10.3390/pharmaceutics12070646.

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Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX. The last three decades have witnessed a sudden boom in aptamer research, owing to their unique characteristics, like high specificity and binding affinity, low immunogenicity and toxicity, and ease in synthesis with negligible batch-to-batch variation. Aptamers can specifically bind to the targets ranging from small molecules to complex structures, making them suitable for a myriad of diagnostic and therapeutic

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14

McCalla, Eric, Matthew Parmaklis, Sarish Rehman, et al. "Combinatorial methods in advanced battery materials design." Canadian Journal of Chemistry, July 26, 2021. http://dx.doi.org/10.1139/cjc-2021-0111.

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In the search for better performing battery materials, researchers have increasingly ventured into complex composition spaces, including numerous pseudo-quaternaries, with numerous further substitutions being either explored experimentally or proposed based on computation. Given the vast composition spaces that need exploring, experimental combinatorial science can play an important role in accelerating the development of advanced battery materials and is arguably the best means to obtain a sufficiently large data set to truly bring a high degree of precision to advanced computational techniqu

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DiCesare, John C., Jennifer Parker, Starr N. Horne, Justin Kita, Raghu Earni, and Christopher Peeples. "Progress in Developing Nerve Agent Sensors Using Combinatorial Techniques." MRS Proceedings 787 (2003). http://dx.doi.org/10.1557/proc-787-g2.3.

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ABSTRACTDevelopment of a sensor capable of selective detection of specific nerve agents is imperative in today’s atmosphere of terrorism. The sensor needs to be inexpensive, portable, reliable, absent of false positives and available to all military and first responders. By utilizing the techniques of molecular imprinting, combinatorial chemistry, silica sol-gel synthesis and lanthanide luminescence, a sensor for the detection of the hydrolysis product of the nerve agent soman is being developed. There are many parameters that require investigation in order for the sensor to become a reality.

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Romero, Iván García, Mubasher Ahmed Bashir, and Harald Pasch. "Determination of chemical composition and molar mass distribution of random styrene-ethyl acrylate copolymers by high-throughput liquid chromatography." e-Polymers 5, no. 1 (2005). http://dx.doi.org/10.1515/epoly.2005.5.1.832.

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AbstractSynthesis and characterization of random copolymers by spectroscopic and chromatographic techniques are normally slow and expensive because most measurements are conducted consecutively and no high-throughput techniques are used. In the present work parallel synthesis and high-throughput analytical techniques for random styrene-ethyl acrylate copolymers were developed. With combinatorial methods, high-throughput instruments and a better design of experiments, the molar mass and chemical composition analyses were carried out simultaneously with time savings of more than 90% as compared

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