Log in

Relevant bibliographies by topics / Synthetic analogs biological activity / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Synthetic analogs biological activity.

Dissertations / Theses on the topic 'Synthetic analogs biological activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 48 dissertations / theses for your research on the topic 'Synthetic analogs biological activity.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Goronga, Tinopiwa. "The synthesis of analogs of Tamiflu via a [3+3] annulation and biological activity of Prunella vulgaris." [Ames, Iowa : Iowa State University], 2006.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Marques, Joaquim Vogt. "Atividade biológica de amidas e análogos de espécies de Piper e estudos biossintéticos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-15062009-100356/.

Full text

Abstract:

Foram isoladas de Piper scutifolium e P. corcovadensis seis amidas, incluindo a piperovatina, piperlonguminina, isopiperlonguminina e corcovadina, duas inéditas (scutifoliamida A e scutifoliamida B), além de duas aristolactamas (piperolactama C e stigmalactama). A partir de P. tuberculatum foram isoladas as amidas piplartina e pelitorina e os ésteres (E)-3,4,5-trimetoxicinamato de etila (11) e 3,4,5- trimetoxidiidrocinamato de etila (12), esse último obtido pela primeira vez de origem natural. Em função da atividade biológica apresentada pelas amidas isoladas, foram sintetizadas 5-fenil-pentad

APA, Harvard, Vancouver, ISO, and other styles

3

Chisholm, Grieg. "Synthesis and biological activity of Pyrrolizidine alkaloids and analogues." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296045.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Robarge, Michael J. "Stable analogues of retinoid-O-glucuoronides: Synthesis and biological activity /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487943610783038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Meyers, Ross Owen. "Anticancer Structure-Activity Relationships of Semi-Synthetic Analogs of Nordihydroguaiaretic Acid." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1086%5F1%5Fm.pdf&type=application/pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Marquissolo, Cilene. "Sintese e atividade biologica de analogos furanicos da goniotalamina." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249248.

Full text

Abstract:

Orientador: Ronaldo Aloise Pilli<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-14T13:10:56Z (GMT). No. of bitstreams: 1 Marquissolo_Cilene_M.pdf: 4919703 bytes, checksum: f834b50c778a98043d8f699e6b2947b9 (MD5) Previous issue date: 2009<br>Resumo: Este trabalho tem como objetivo preparar análogos furânicos da goniotalamina 31, 32 e 33 em suas duas formas enantioméricas, utilizando-se a alilação catalítica e assimétrica nas condições de Keck e a reação de metátese de olefinas para fechamento de anel. Estes análogos fo

APA, Harvard, Vancouver, ISO, and other styles

7

Borràs, Tudurí Roser. "Non-glycosidic analogues of alpha-galactosylceramide: Design, synthesis and biological activity." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/587193.

Full text

Abstract:

The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to defense the body against threatens. IS is organized into two lines of defense: innate immunity which acts in a non-specific manner and adaptive immunity, able to release a specific response. Natural Killer T cells (NKT) are a IS cell class that combine features of Natural Killer cells (innate immunity) and T cells (adaptive immunity), and are able to trigger IS to combat a threat (pro-inflammatory cytokines - Th1 response) as well as regulate it (anti-inflammatory cytokines – Th2 response). This versatili

APA, Harvard, Vancouver, ISO, and other styles

8

Nakajima, Suanne K. "Synthesis and biological activity of some novel side-chain analogues of brassinolide." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0018/MQ48078.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Andersen, Denise Lyn. "Synthesis and biological activity of brassinolide and analogues, approaches towards the synthesis of xestobergsterol A." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/NQ54825.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Blaih, Salah El-Din M. "Electrochemical studies of trimetoquinol analogs and catecholimidazolines: A correlation to biological activity /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487586889188153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Fell, Patricia L. "Cellular uptake and biological activity of synthetic hammerhead ribozymes." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10973/.

Full text

Abstract:

The potential use of synthetic hammerhead ribozymes as novel anti-brain tumour agents was investigated in this study. Chimeric 2'-O-methylated hammerhead ribozymes proved to be significantly more stable (>4000-fold) in serum than unmodified RNA ribozymes and exhibited high in vitro catalytic activity. The cellular association of an internally [32P]-labelled 2'-O-methylated chimeric ribozyme in U87-MG human glioma cells was temperature-, energy- and pH-dependent and involved an active process that could be competed with a variety of polyanions. Indications are that the predominant mechanism of

APA, Harvard, Vancouver, ISO, and other styles

12

Rosenberg, Heidi J. "Synthesis and biological activity of mimics of D-myo-inositol 1,4,5-trisphosphate and adenophostin A." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Rathnam, Rajendra Prasad. "Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/8110/.

Full text

Abstract:

The 1,4-benzodiazepin-2-one motif has been taken as a privileged skeleton for making antitrypanosomal agents. A library of over sixty 1,4-benzodiazepin-2-one derivatives has been synthesised employing novel synthetic routes. These derivatives were characterised spectroscopically, by mass spectrometry, and by combustion analysis. Five derivatives were characterised, in the solid state, by single crystal X-ray crystallography. Biological assays of the library of compounds against Trypanosoma brucei brucei (T. b brucei) revealed a range of trypanocidal activities. A first generation library activ

APA, Harvard, Vancouver, ISO, and other styles

14

Woznichak, Michelle Marie Gill. "Investigation of the biochemical activity of phenylaminoethyl selenide compounds, synthetic substrate analogs for dopamine beta-monooxygenase." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/26211.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

CODY, WAYNE LIVINGSTON. "SYNTHESIS, BIOLOGICAL ACTIVITY AND CONFORMATIONAL ANALYSIS OF FRAGMENT ANALOGUES OF ALPHA-MELANOTROPIN (PEPTIDE, STRUCTURE-FUNCTION, PHENYLGLYCINE, NMR, TETRAHYDROISOQUINOLINE-3-CARBOXYLATE)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188044.

Full text

Abstract:

α-MSH (α-melanotropin) is a naturally occurring linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂) that is primarily known for its ability to stimulate integumental melanocytes and more recently has been implicated in a variety of physiological and neurological processes. It has been shown that substitution of D-phenylalanine in the seven position of this hormone led to an analogue with increased potency and prolonged biological activity. Furthermore, cyclization between the four and ten positions via a cystine bridge led to analogues with enhanced potency. In t

APA, Harvard, Vancouver, ISO, and other styles

16

Saint-Auret, Sarah. "Synthèse totale de mycolactone A/B et d'analogues ciblés pour l'étude mécanistique de l'ulcère de Buruli." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF049.

Full text

Abstract:

L’ulcère de Buruli est une maladie nécrotique de la peau présente dans plus de trente pays dans le monde, et affectant principalement le continent africain et l’Océanie. L’infection est due à Mycobacterium ulcerans (M. ulcerans), un micro-organisme qui sécrète une exotoxine appelée mycolactone, représentant le premier polycétide isolé d’un pathogène humain. La maladie est caractérisée par la formation progressive de lésions nécrotiques combinée à une absence de réponse immunitaire et de sensation de douleur ; la mycolactone est connue pour être directement impliquée dans ce mécanisme biologiqu

APA, Harvard, Vancouver, ISO, and other styles

17

Qwebani, Tozama. "Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/9281.

Full text

Abstract:

Includes bibliographical references (leaves 107-111).<br>The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key step

APA, Harvard, Vancouver, ISO, and other styles

18

Nilsson, Ulf. "Structural requirements for glycolipid receptors recognized by uropathogenic E. coli synthetic and biological studies with fragments and analogs of globo oligosaccharides /." Lund : Organic Chemistry 2, Lund Institute of technology, University of lund, 1995. http://books.google.com/books?id=EjdsAAAAMAAJ.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Yang, Zongchang, and 楊宗昌. "Synthetic ion channels based on peptides and aminoxy acid foldamers : structure, activity and biological study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206314.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Besaans, Ethan Wade. "Synthesis structure-activity relationships and biological evaluation of optimised terminally alkylated (bis)urea and (bis)thiourea polyamine analogues as antiplasmodial agents." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63227.

Full text

Abstract:

The sustained control and elimination of malaria requires novel approaches to combat the emergence of drug resistance. Plasmodium falciparum causes the most lethal form of human malaria. Current therapeutics have shown decreased efficacy as a result of P. falciparum developing resistance to them. Consequently, novel antimalarial agents with new mechanisms of action are urgently needed to aid in the control and ultimate eradication of this disease and should display low resistance indices and high selectivity indices. Polyamines are involved in a variety of cellular functions including c

APA, Harvard, Vancouver, ISO, and other styles

21

Siemon, Thomas [Verfasser]. "Synthesis and Functionalization of Highly Biologically Active Terpene Natural Products − Total Synthesis of (+)-Darwinolide and Semisynthesis of (−)-Englerin A and Structure-Activity Relationship Studies of Analogs / Thomas Siemon." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1205314946/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Abdelhamid, Dalia. "Natural Products as Lead Compounds for Drug Development. Part I: Synthesis and Biological Activity of a Structurally Diverse Library of Curcumin Analogues. Part II: Synthesis of Novel Sterol Natural Products and Related Analogues as Antileishmanial Ag." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299685922.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Springett, Bradley Ross. "Design, synthesis and biological evaluation of inhibitors of polysialyltransferases PST and STX : design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/13528.

Full text

Abstract:

Polysialylated NCAM (polySia-NCAM) is re-expressed in a number of tumours, including small cell lung carcinoma and neuroblastoma and is strongly associated with aggressive, invasive and metastatic tumours in the clinic. SiRNA knockdown of the polysialyltransferases (polySTs), the enzymes responsible for polysialylation of neural cell adhesion molecule (NCAM), has been shown to abolish cell migration. PolySia-NCAM is thus a highly attractive novel therapeutic target. A library of potential polyST inhibitors has been synthesised, using substrate-based design and computational chemistry. Compound

APA, Harvard, Vancouver, ISO, and other styles

24

Springett, Bradley R. "Design, Synthesis and Biological Evaluation of Inhibitors of Polysialyltransferases PST and STX. Design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/13528.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Ploux, Olivier. "Synthèse d'analogues cycliques de la substance P : études biochimiques et structurales." Paris 6, 1986. http://www.theses.fr/1986PA066076.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

La, Pensée Louise Josephine Ilse. "Endoperoxides as antimalarials and the application of singlet oxygen to the synthesis of key intermediaries en route to synthetic 1,2,4-trioxanes and synthesis and biological activity of minor groove binding-artemisinin conjugates." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533991.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Furno-de, Winter Agnès. "Synthese d'agonistes et d'antagonistes du paf (platelet activating factor) : etude pharmacotoxicologique." Paris 7, 1988. http://www.theses.fr/1988PA077055.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Fokoue, Harold Hilarion. "Síntese, atividades biológicas e estudo de relação estrutura-atividade de piperamidas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-25032015-105445/.

Full text

Abstract:

As estruturas e propriedades biológicas das amidas piplartina e a piperina, isoladas respectivamente de Piper tuberculatum e P. nigrum, inspiraram a síntese de 89 derivados e 7 esters estruturalmente relacionadas. As preparações envolveram metodologias tradicionais e os compostos purificados tiveram suas estruturas caracterizadas por análises espectroscópicas e espectrométricas. Os estudos de fragmentação por IE e IES indicaram a clivagem preferencial da ligação N-CO no caso das cinamamidas, dienamidas e cinamimidas. Estudos computacionais envolvendo afinidade protônica e energias de ligação c

APA, Harvard, Vancouver, ISO, and other styles

29

Novaes, Karla Teixeira Farias de. "Síntese de derivados do megazol, com potencial atividade tripanosomicida." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-18122017-100516/.

Full text

Abstract:

Este projeto visa à obtenção do megazol e de seus derivados, que possam ser comparados quanto a sua atividade biológica, no intuito de produzir um análogo mais potente e menos tóxico. O megazol, estrutura de interesse do trabalho proposto, foi sintetizado inicialmente em 1968 por Asato e Berkelhammer utilizando o 5-nitroirnidazol como material de partida. Nos anos 80, pesquisadores brasileiros da Fundação Instituto Oswaldo Cruz e do Centro René Rachou, devido a grande incidência da doença de Chagas no Brasil, relacionaram um grande número de substâncias químicas até então indicadas como ativas

APA, Harvard, Vancouver, ISO, and other styles

30

Dufrénoy, Pierrick. "Valorisation en synthèse organique d'éco-catalyseurs hétérogènes régénérables à partir de matériaux verts cultivés sur des sols contaminés." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMLH30/document.

Full text

Abstract:

Les activités des anciennes industries métallurgiques spécialisées dans la production et la transformation de plomb, de zinc ou d’autres métaux ont engendré une pollution métallique importante des sols selon la localisation de ces derniers. Des études actuelles proposent ainsi des solutions de requalification de ces sols via des processus de phytoremédiation afin de valoriser au maximum les plantes cultivées sur ces sols contaminés. Ce projet de thèse a ainsi été réalisé dans le but de valoriser des écocatalyseurs hétérogènes régénérables. Ces derniers sont obtenus à partir des plantes cultivé

APA, Harvard, Vancouver, ISO, and other styles

31

Benevides, Norma. "Relation entre l'activité herbicide de quelques composés et leur liaison à des protéines ou à des structures membranaires isolées." Grenoble 1, 1987. http://www.theses.fr/1987GRE10143.

Full text

Abstract:

Le travail presente dans ce memoire est une etude des relations pouvant exister entre l'activite de composes herbicides inhibiteurs de la division cellulaire chez les vegetaux et leur liaison a des proteines (tubuline, serum albumine bovine=sab) ou a des structures membranaires (thylakoides). Nous avons constitue une serie d'inhibiteurs connus de la division cellulaire (propyzamide, butraline, pentachlorophenol=pcp, colchicine et deux phenylcarbamates: prophame et chlorprophame=cipc). Nous avons verifie leur efficacite et compare celle-ci a l'activite de 19 pyridilcarbamates nouveaux (. . . )

APA, Harvard, Vancouver, ISO, and other styles

32

黃維生. "Synthesis and Biological Activity of Dolastatin 15 Analogs." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/30521255003408553995.

Full text

Abstract:

碩士<br>國防醫學院<br>藥學研究所<br>85<br>The Depsipeptide of Dolastatin 15, isolated from Indian sea hare Dolabella auricularia (Aplysiidae) by Pettit and co - workers, possessed powerful antineoplastic activity. In order to study the the structure - activity relationship of Dolastatin 15 on antitumor system, we synthesized a series of dolastatin 15 analogs modified at the side chain, backbone, and heterocycle moiety. 　　Construction of Dolastatin 15 started from the C - terminal acyl - pyrrolidinone, where L - hydroxyisovaleric acid (Hiva) was first coupled with phenylalanine benzyl ester by using PyBOP

APA, Harvard, Vancouver, ISO, and other styles

33

Holt, Jason James. "Synthesis, photophysical properties, and biological activity of tetramethylrosamine analogs." 2008. http://proquest.umi.com/pqdweb?did=1542154241&sid=13&Fmt=2&clientId=39334&RQT=309&VName=PQD.

Full text

Abstract:

Thesis (Ph.D.)--State University of New York at Buffalo, 2008.<br>Title from PDF title page (viewed on Dec. 3, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Detty, Michael R. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

34

Xiao, Yu Mei, and 蕭玉玫. "Synthesis, biological activity, and structural analysis of waglerin-1 analogs." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/29085516211326160765.

Full text

Abstract:

碩士<br>國立臺灣大學<br>生化科學研究所<br>83<br>Trimeresurus Wagleri, also known as the speckled pit viper, is abundant in south-eastern Asia. Waglerin-1 is one of the two main lethal components of T. Wagleri venom. The primary sequence of Waglerin-1 has been determined as followed: 5 10 15 20 GGKPDLRPCHPPCHYIPRPKPR There is an intramolecular disulfide bond within it. In order to understand the relationship between the structure and biooological activity of W

APA, Harvard, Vancouver, ISO, and other styles

35

Gutierrez, Julio. "Design and Synthesis of Novel Tylophorine Analogs and their Biological Activity." 2009. http://trace.tennessee.edu/utk_graddiss/603.

Full text

Abstract:

Alkaloids containing the nitrogen atom in the bridgehead position of two rings, such as indolizidine, pyrrolizidine, and quinolizidine alkaloids, have a wide and varied distribution in nature. Some of these alkaloids demonstrate a broad range of pharmacological activities and have generated substantial synthetic interest. This thesis covers the total synthesis of novel tylophorine analogs called DCB 3503, DCB 3506, DCB 3507, DCB 3508, DCB 3509, and a derivative with a biotinylated chain attached to DCB 3506 for use as a biological probe. This thesis discusses the biological activity of these c

APA, Harvard, Vancouver, ISO, and other styles

36

Weng, Yi-Lien, and 翁溢蓮. "Synthesis and Biological Activity of Combretastatin A-4 1,2,3-Triazole Analogs." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/89002234396082593926.

Full text

Abstract:

碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士在職專班<br>97<br>We use the coupling reaction of Pd to form a diaryl acetylene, generated diaryl acetylene, adding NaN3, the use of synthetic triazole ring of addition reaction, developed by microwave digestion method, to establishment appropriate microwave temperature and solvent, synthesis a series of Combretastatin A-4 1,2,3 - triazolo analogues (31a - f ), the yield is 30% to 86%, by cell cycle of human leukemia K-562 tumor cell line to evaluate its biological activity.

APA, Harvard, Vancouver, ISO, and other styles

37

aih-Jing, Chiou, and 邱愛菁. "Studies on the Synthesis, Structural Analysis and Biological Activity of Destruxin B Analogs." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/29313878951028095731.

Full text

Abstract:

碩士<br>國立臺灣大學<br>生化科學研究所<br>81<br>Destruxin B, first isolated from culture filtrates of the insect pathogenic fungus Metarrhizium anisopliae, is cyclo-(D- .alpha.-hydroxy-.gamma.-methylvaleryl-L-prolyl-L-isoleucyl-N- methyl-L-valyl-N-methyl-L-alanyl-.beta.alanyl). According to the studies of structure-activity relationship, it was believed that the ester bond and N-methyl groups in the structure of destruxin B might play an important role in biological activity. Therefore, the analyogs of d

APA, Harvard, Vancouver, ISO, and other styles

38

Miller, Duncan Ashley. "A study of the metabolism and biological activity of retinoic acid, its metabolites, and two synthetic analogues." 1985. http://catalog.hathitrust.org/api/volumes/oclc/12876122.html.

Full text

Abstract:

Thesis (Ph. D.)--University of Wisconsin--Madison, 1985.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 203-210).

APA, Harvard, Vancouver, ISO, and other styles

39

Marková, Jana. "Syntéza derivátů haemanthaminu." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-379170.

Full text

Abstract:

6 Abstract Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Jana Marková Supervisor: doc. Ing. Lucie Cahlíková, Ph.D. Title of Diploma thesis: Synthesis of haemanthamine derivatives Based on previous studies, the haemanthamine alkaloid showing remarkable antitumorous activity was chosen as the subject of this thesis. The purpose of the thesis was preparation of its more active derivatives, namely esters. Preparation concerns the following derivatives: 11- O- butanoylhaemanthamine, 11-O-(3,4-dimethoxybenzoyl)-haemanthamine, 11-O

APA, Harvard, Vancouver, ISO, and other styles

40

CHENG-MING, CHEN, and 陳政銘. "Synthesis and Biological Activity of Ugonins C,F and Analogues." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/vgbaqr.

Full text

Abstract:

碩士<br>中國文化大學<br>化學系應用化學碩士班<br>107<br>Daodi-Ugon is a herbal medicine commonly used in Taiwan as an antipyretic and antiphlogistic agent. Its scientific name is Helminthostachys zeylanica. Its dry rhizoma has been included in the third edition of the Taiwan Herbal Pharmacopeia published in 2018. Ugonin C and Ugonin F were isolated as two minor components and there is currently no relevant synthetic report. In this thesis, an efficient synthetic method was accomplished to synthesize Ugonin C and Ugonin F. Antioxidant activity was also evaluated. The key intermediate 1-(6-hydroxy-4-methoxy-2,

APA, Harvard, Vancouver, ISO, and other styles

41

Kuo, Chiung-Wen, and 郭瓊文. "Synthesis and Biological Activity of N1- and N2-benzyl-3-(3-substituted phenyl)indazole Analogues." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/01241532472425325682.

Full text

Abstract:

碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>Abstract Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was synthesized in our laboratory as a novel thrombin-receptor antagonist. In this study, YD-3 was used as a lead compound and a series of its derivatives were synthesised. Subsequent the starting material mono-methyl isophthalate was treated with thionyl chloride on chlorination, and then reacts with 1-(N-morpholino)cyclohexene to afford 3-[(2-oxocyclohexyl)- carbonyl]- benzoate (5). Next, the compound 5 reacts with hydrazine hydrate to afford 3-(4-methylphenyl)-4,5,6,7-tetrahydro-1H-indazole (6). S

APA, Harvard, Vancouver, ISO, and other styles

42

Stephenson, M. J., L. A. Howell, M. A. O'Connell, et al. "Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity." 2015. http://hdl.handle.net/10454/10171.

Full text

Abstract:

Yes<br>The duocarmycins are potent antitumour agents with potential in the development of antibody drug conjugates (ADCs) as well as being clinical candidates in their own right. In this paper, we describe the synthesis of a duocarmycin monomer (DSA) that is suitably protected for utilisation in solid phase synthesis. The synthesis was performed on a large scale and the resulting racemic protected Fmoc-DSA subunit was separated by supercritical fluid chromatography (SFC) into the single enantiomers. Application to solid phase synthesis methodology gave a series of monomeric and extended

APA, Harvard, Vancouver, ISO, and other styles

43

TASI, CHIA-FANG, and 蔡佳芳. "Total synthesis of CAPE (caffeic acid phenethyl ester) -like analogues and study on their biological activity." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/48715015279602065090.

Full text

Abstract:

碩士<br>中山醫學院<br>毒理學研究所<br>87<br>Propolis, a honey bee hive product, exhibits a broad spectrum of medical application including antibiotic, antiviral, anti-inflammatory and tumor growth inhibition; some of the observed biological effects may be due to caffeic acid (cinnamic acid) esters that are present in propolis. In the present work we synthesized five caffeic acid esters, namely 3-(3,4-dihydroxyphenyl)acrylic acid phenethyl ester (CAPE), 3-(3,4-dimethoxyphenyl)acrylic acid phenethyl ester (PEDMC), 3-(3,4-dihydroxyphenyl)acrylic methyl ester (MC), 3-(3,4-dihydroxyphenyl) acrylic acid ethyl es

APA, Harvard, Vancouver, ISO, and other styles

44

Schmidt, Annika [Verfasser]. "A general synthetic strategy and biological activity of B1-Phytoprostanes / Annika Schmidt." 2007. http://d-nb.info/984635033/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Maia, Renato Ribeiro. "Biomimetic catalysis of flavones derivatives using a synthetic porphyrin." Master's thesis, 2018. http://hdl.handle.net/10773/25489.

Full text

Abstract:

Since flavones present a diverse and vast list of biological activities, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antiviral, antidiabetic, anti-allergic, activities or modulation of enzyme activity or metabolic pathways like the lipid metabolism, the synthesis of new flavones bearing uncommon patterns may be extremely useful. Though, these new flavone derivatives may be bioactive, one question needs to be answered, are they properly metabolized in biological systems? To answer that, biomimetic studies are a good strategy and synthetic porphyrins can be used in biomi

APA, Harvard, Vancouver, ISO, and other styles

46

Gordon, Allen Tauya. "Synthetic studies and biological evaluation of chromone - 3 - carbaldehydes." Diss., 2018. http://hdl.handle.net/11602/1214.

Full text

Abstract:

MSc (Chemistry)<br>Department of Chemistry<br>Chromones are well known naturally occurring heterocyclic compounds with oxygen as a heteroatom. Chromones are also one of the major classes of naturally occurring compounds, and the interest in their chemistry is due to their wide range of their biological activity. In this study, three classes of target compounds were synthesized through three different pathways. The first pathway, chromone-3-carbaldehyde analogues were afforded in good to excellent yield followed by the oxidation thereof to 4-oxo-4H-chromene-3-carboxylic acids. A series of chro

APA, Harvard, Vancouver, ISO, and other styles

47

Liao, Ching-Lun, та 廖敬倫. "Synthesis of Conformationally Constrained α-Galactosylceramide Analogues by exo-Glycal Chemistry and Evaluation of Biological Activity on Natural Killer T Cells". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/49791640622901330881.

Full text

Abstract:

碩士<br>國立臺灣大學<br>生化科學研究所<br>95<br>Natural killer T (NKT) cells are a novel subset of T cells that express both T-cell and natural killer (NK)-cell markers. NKT cells recognize non-classical MHC class I molecule CD1d in conjunction with glycolipid antigens. Among the reported glycolipids presented by human or mouse CD1d, α-galactosylceramide (α-GalCer) shows the highest immune-stimulatory activities. α-GalCer is derived from a marine sponge natural product and has been shown to possess antitumor activity. Further studies indicate that α-GalCer can bind to CD1d and activate NKT cells through T ce

APA, Harvard, Vancouver, ISO, and other styles

48

McCarthy, Anna R. "Biological activity of steroid analogues : synthesis and receptor/enzyme interactions : a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry at the University of Canterbury /." 2006. http://library.canterbury.ac.nz/etd/adt-NZCU20060724.203418.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!