Log in

Relevant bibliographies by topics / Synthetic derivatives / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Synthetic derivatives.

Dissertations / Theses on the topic 'Synthetic derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Synthetic derivatives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Stockmann, Vegar. "Synthetic Applications of Nitropyridine Derivatives." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kjemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-12220.

Full text

Abstract:

The present work represents a continuation of the investigation of the chemistry of nitropyridine derivatives, based on the methodology for nitration of pyridines developed by Professor Jan M. Bakke and co-workers at NTNU. Nitropyridines have been utilized as substrates for the formation of novel bis- and tris-heterocyclic compounds, and new synthetic routes to fused heterocycles have been developed. Several new β-carboline analogues and fused azacinnolines have been prepared based on a Suzuki coupling and subsequent cyclization approuch. The formation of 4-isocyanobut-2-enenitrile and 3-cyano

APA, Harvard, Vancouver, ISO, and other styles

2

Karim, Rehana. "Development of radical synthetic methodology using solid-phase organic synthesis." Thesis, Loughborough University, 2003. https://dspace.lboro.ac.uk/2134/34406.

Full text

Abstract:

The synthesis of heterocycles using radical intermediates has become an important area of research in recent years. The aim of our research was to develop radical methodologies to construct heterocycles on solid-support. Tri-cyclic benzimidazole derivatives are desirable synthetic targets with a range of biological activity and are part of certain anti-tumour agents. Solid-supported radical reactions with substituted benzimidazoles were performed under different experimental conditions, including different solvents, three different resins (Wang, Merrifield and Rink) and different radical reage

APA, Harvard, Vancouver, ISO, and other styles

3

Navasero, Neenah. "Synthetic routes to non-symmetric tropones." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101647.

Full text

Abstract:

The synthesis of substituted non-symmetric tropones has proven to be a considerable synthetic challenge. Particularly, a 3,4,6-tnsubstituted tropone which is required for the total synthesis of CP-225,917 is currently being undertaken by our group.<br>Two approaches towards the synthesis of substituted tropones are presented. Both utilize linear diene precursors which are closed to 7-membered cycloheptene rings via ring closing metathesis. In the first method, linear precursors are synthesized by addition of nucleophilic substituents to carbonyl groups to form alcohol groups. After forming the

APA, Harvard, Vancouver, ISO, and other styles

4

Howarth, Nicola. "Synthetic approaches to derivatives of tropane." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/33742.

Full text

Abstract:

This thesis is a continuation of the work by Bathate, which had shown that intramolecular cyclisation of trans-1- (benzylamino)-4-chlorocycloheptane and hept-2-ene gave the corresponding nortropane and nortrop-6-ene derivatives. Problems were experienced in the reproducibility of Bathgate's route. Therefore, the intramolecular cyclisation step warranted further development. The best yields of cyclised products were attained when the solvent was changed to acetone. Other approaches to nortropane were sought. Reasonable yields of the cyclised material were only obtained when the nitrogen functio

APA, Harvard, Vancouver, ISO, and other styles

5

Stewart, Alistair J. "Synthetic studies in nucleoside chemistry." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232863.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Bode, Moira Leanne. "Synthetic and spectroscopic studies of indolizine derivatives." Thesis, Rhodes University, 1994. http://hdl.handle.net/10962/d1005050.

Full text

Abstract:

The crystalline compound resulting from thermal cyclization of the Baylis-Hillman product, methyl 3-hydroxy-2-methylene-3-(2-pyridyl)propanoate, has been identified as the indolizine derivative, methyl indolizine-2-carboxylate, and this approach involving the reaction of pyridine-2-carboxaldehydes and acrylate analogues has been established as a general route to 2-substituted indolizines. The ease of cyclization the Baylis-Hillman products to indolizines has been shown to increase by converting the hydroxy group to an acetoxy group, and a range of acetylated Baylis-Hillman products were prepar

APA, Harvard, Vancouver, ISO, and other styles

7

Gelebe, Aifheli Carlson. "Synthetic and spectrometric studies of benzodioxepinone derivatives." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1005047.

Full text

Abstract:

An extensive range of oxygen and sulphur substituted benzodiazepine analogues has been synthesised via Baeyer-Villiger and Schmidt reactions of specially prepared flavanone and N-acetyl-4-quinolone precursors. Alternative, cyclisation routes have also been used to prepare some of these compounds. Ring-opening reactions of 1,5-benzodioxepinones have been investigated and a detailed kinetic-mechanistic study of the Baeyer-Villiger reaction of flavanones has been carried out using 1 H NMR spectroscopy to explain the observed regiochemistry of oxygen insertion. The electron-impact mass spectrometr

APA, Harvard, Vancouver, ISO, and other styles

8

Lobb, Kevin Alan. "Camphor derivatives in asymmetric synthesis: a synthetic, mechanistic and theoretical study." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1006770.

Full text

Abstract:

A series of 3,3-ethylenedioxy-exo- and endo- bornyl esters have been prepared and subjected to α-benzylation using lithium diisopropylamide and benzyl bromide. In the exo-series of esters the diastereofacial selectivity of benzylation was found to improve (up to 34% d.e.) as the steric bulk of the O-alkyl group increased, whereas in the endo-series, a surprising decrease in stereoselectivity was observed as the steric bulk increased – an observation attributed to flexibility of the metal-coordinated endo-enolate system, compared to the relative rigidity of the exo analogues. The conformational

APA, Harvard, Vancouver, ISO, and other styles

9

Lilley, Ian Andrew. "Synthetic studies using chiral stabilised azomethine ylids." Thesis, University of Oxford, 1995. https://ora.ox.ac.uk/objects/uuid:64d5745b-e6ef-4a77-8abe-b01f1c627e8f.

Full text

Abstract:

The work described herein is concerned with the [3+2] dipolar cycloaddition of amino acid derived azomethine ylids. Such cycloadditions are a highly efficient technique for the construction of proline derivatives, and may potentially be employed in other areas of asymmetric synthesis. Chapter 1 commences with a brief review of natural and synthetic, proline containing, molecules. Approaches to the synthesis of the proline moiety are described, focusing on previously developed methods for performing the [3+2] dipolar cycloaddition in a chiral manner. The methodology employed in this thesis is s

APA, Harvard, Vancouver, ISO, and other styles

10

Langnel, David Antoine Fernand. "New synthetic routes to antitumour imidazotetrazines." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311742.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Woods, Gordon Alexander. "Synthetic approaches to functionalised piperidines." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4c6fdb6c-c021-447c-8fc9-35241b552850.

Full text

Abstract:

This thesis is concerned with the synthesis of functionalised piperidines. The piperidine unit is found in numerous alkaloids and other natural products, and has also been incorporated into synthetic compounds of significant therapeutic or strategic synthetic potential. Although numerous syntheses of individual piperidine compounds have been published, there are few general routes to this class of compounds, and there is therefore a need for such routes to be developed. Bicyclic lactams derived from (S)-pyroglutamic acid have been shown to be useful synthons in the synthesis of pyrrolidines. A

APA, Harvard, Vancouver, ISO, and other styles

12

Ling, Kenneth B. "Stereoselective cyclopropanations of allylic amines and derivatives." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:15907329-15e7-4cbd-ba46-2735ff4129ea.

Full text

Abstract:

This thesis is concerned with the development and application of methods for the stereoselective cyclopropanation of allylic amines and derivatives. Firstly, a highly chemo- and stereoselective cyclopropanation of N,N-dibenzyl-protected allylic amines was developed using the highly reactive Shi’s carbenoid [CF₃CO₂ZnCH₂I]. Subsequent mechanistic studies revealed that the high diastereoselectivity of the reaction was likely to be due to coordination of the amine to the zinc carbenoid reagent. It is then shown that the reaction is general for a wide range of both cyclic and acyclic substrates giv

APA, Harvard, Vancouver, ISO, and other styles

13

Ramaite, Ipfani David Isaiah. "Synthetic and physical organic studies of chromone derivatives." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1005045.

Full text

Abstract:

A range of chromone-2-carboxylic acids has been prepared by condensing suitably substituted 2-hydroxyacetophenones with diethyl oxalate. pK₂ Studies of these acids revealed that 6- or 7-methoxy substituents decreased acidity while the 6-nitro group enhanced acidity; the strongest acid was the 3-chloro derivative, the increase in acidity being attributed to steric inhibition of acid-weakening delocalisation between the carboxyl group and the chromone system. Various chromone-2-carboxamides, derived from acid chloride precursors, were converted to polysubstituted acrylamides by nucleophilic ring

APA, Harvard, Vancouver, ISO, and other styles

14

Broberg, Karl Rufus. "Synthetic approaches towards heparinoid related saccharides and derivatives." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/synthetic-approaches-towards-heparinoid-related-saccharides-and-derivatives(6c1366ba-82dc-43b2-9af3-294ebed56639).html.

Full text

Abstract:

Heparin glycosaminoglycans mediate a range of biological events, including anticoagulation as well as a diversity of cell proliferation and differentiation processes. Heparin saccharides have been shown to act as inhibitors against angiogenesis and metastasis of tumour cells. This thesis describes work developing chemistry towards varying length oligosaccharide sequences with potential to offer variable sulfation patterns. The main synthetic components to this work were contribution to developing scalable syntheses of an orthogonally protected L-Iduronic acid unit and a differentially protecte

APA, Harvard, Vancouver, ISO, and other styles

15

Yoshida, Suguru. "Studies on Synthetic Reactions of Ketene Dithioacetal Derivatives." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/77960.

Full text

Abstract:

Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第14581号<br>工博第3049号<br>新制||工||1454(附属図書館)<br>26933<br>UT51-2009-D293<br>京都大学大学院工学研究科材料化学専攻<br>(主査)教授大嶌幸一郎, 教授檜山爲次郎, 教授松原誠二郎<br>学位規則第4条第1項該当

APA, Harvard, Vancouver, ISO, and other styles

16

Godbert, Nicolas. "Anthracenediylidene derivatives : control of molecular and supramolecular architecture." Thesis, Durham University, 2002. http://etheses.dur.ac.uk/3818/.

Full text

Abstract:

In the context of new π-donor molecules, extended tetrathiafulvalenes have been widely studies for their use as components of electronically conductive charge-transfer materials. In contrast with the planar π -systems, we have focused our attention on extended tetrathiafulvalenes containing a conjugated anthracenyl spacer (anthracenediylidene derivatives). These TTF derivatives adopt a saddle-shaped conformation in the neutral state and a drastic change of conformation occurs upon oxidation to the dication species. Our main objective was to investigate the molecular and supramolecular architec

APA, Harvard, Vancouver, ISO, and other styles

17

Weber, Jeffrey Charles. "Synthetic approaches to structurally interesting, spherical hydrocarbons and synthesis of monosubstituted dodecahedrane derivatives /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu148758688918668.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Borgini, Matteo. "Synthesis and biological evaluation of chemotherapeutic macrocycle derivatives of natural and synthetic origin." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1094596.

Full text

Abstract:

Viene riportata la sintesi e la caratterizzazione biologica ed anti-proliferativa di derivati della molecola naturale Largazolo in grado di rilasciare ossido nitrico e di fornire un effetto antitumorale duale nei confronti di alcune linee cellulari tumorali. Inoltre, è riportato l'approccio sintetico utilizzato per lo scale-up della molecola antifungina BM1 per la quale sono stati condotti test di farmacocinetica e di tossicità.

APA, Harvard, Vancouver, ISO, and other styles

19

Fikri, Cem. "Valuation of synthetic CDOs and related portfolio credit derivatives." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/12014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

King, M. D. "Synthetic studies of some derivatives and analogues of glutathione." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380584.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Finokaliotou, Sophia. "Synthetic and biological studies of antiparasitic natural product derivatives." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518105.

Full text

Abstract:

Trypanosomiasis and Leishmaniasis are tropical diseases caused by the parasites Trypanosoma and Leishmania, that cause severe medical and economical problems for millions of people in the developing world. Trypanosomiasis can be divided into African and American trypanosomiasis, which are caused by Trypanosoma brucei and Trypanosoma cruzi respectively. There are more than 20 different species of Leishmania worldwide that cause Leishmaniasis, but the most severe infection, visceral leishmaniasis, is caused by Leishmania donovani. Both diseases are transmitted by blood sucking insects like the t

APA, Harvard, Vancouver, ISO, and other styles

22

Kerkhoff, Aleta van. "Interactions between streptavidin and synthetic derivatives of gramicidin A." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27558.

Full text

Abstract:

1. Three biotinylated derivatives of Lucifer Yellow ethylenediamine (BLY, BXLY and BXXLY) were synthesised using three different NHS-esters of biotin (BNHS, BXNHS and BXXNHS, respectively) so that the effect of molecular spacers upon the emission characteristics of the Lucifer Yellow moiety could be determined (X = C5 spacer; XX = C14 spacer). BLY, BXLY and BXXLY were purified by reverse-phase HPLC. 2. The ability of SA to interact with each biotinylated derivative of Lucifer Yellow ethylenediamine was demonstrated. Interactions between SA and BLY, BXLY or BXXLY were accompanied by si

APA, Harvard, Vancouver, ISO, and other styles

23

Khairnar, L. B. "Synthetic studies towards pipecolic acid, its 3-hydroxy derivatives and development of synthetic methodology." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2012. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Clancy, Gerald Patrick. "Synthetic inorganic chemistry : novel metallocenes and inorganic fullerenes." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:9c7f7c35-bb8f-4117-8e2e-e56a9fbcbeab.

Full text

Abstract:

This thesis is divided into two parts. The first part concerns the synthesis and characterisation of substituted metallocene complexes of the transition and main group metals. The second part describes the preparation and characterisation of inorganic fullerene (IF)-related materials. <strong>Chapter 1</strong> reviews the chemistry of dialkyl- and diaryl-phosphino substituted cyclopentadienyl complexes of the transition metals. <strong>Chapter 2</strong> describes the synthesis and characterisation of the new ligands [M(C<sub>5</sub>Me<sub>4</sub>)CH<sub>2</sub>PMe<sub>2</sub>] (M = H, Li, Na

APA, Harvard, Vancouver, ISO, and other styles

25

Subasi, Nuriye Tuna. "Novel Synthetic Methodologies For Heeocycles As Building Blocks In Drug Synthesis." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613028/index.pdf.

Full text

Abstract:

Nitrogen containing heterocycles have always constituted a subject of great interest due to their wide presence in biologically important compounds so the development of efficient methods for the preparation of pyrrole derivatives and formation of new pyrrole-based heterocyclic compounds are an attractive goal in heterocyclic chemistry. In this study, starting from dimethoxytetrahydrofurane and amino acid esters, unsubstituted pyrrole derivatives, and treatment of amino acid esters with convenient chloroenones 1,2-disubstituted and 1,2,4-trisubstituted pyrrole derivatives were synthesized with

APA, Harvard, Vancouver, ISO, and other styles

26

Papineni, Sabitha. "New synthetic derivatives of triterpenoids in the treatment of cancer." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Berk, Mujde. "Development Of New Synthetic Methodologies For Isoquinolone And Isoindolinone Derivatives." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612145/index.pdf.

Full text

Abstract:

ABSTRACT DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES FOR ISOQUINOLONE AND ISOINDOLINONE DERIVATIVES M&uuml<br>jde, Berk M.Sc., Department of Chemistry Supervisor: Prof. Dr. Metin Balci July 2010, 146 pages Due to the wide range of physiological activities, heterocycles containing nitrogen and oxygen have always attracted the interest of chemists. The objective of this research is to develop new synthetic routes to the synthesis of isoquinolone and isoindolinone derivatives starting from 2-(2-carboxyethyl)benzoic acid and homophthalic acid, respectively. The half ester produced from 2-(2-carboxy

APA, Harvard, Vancouver, ISO, and other styles

28

Abualnaj, Matoka h. Mohammed A. "Diastereoselective synthetic approaches to functionalised tetrahydropyrrolo[3,4-a] carbazole derivatives." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3265.

Full text

Abstract:

The heterocyclic carbazoles are privileged scaffolds present in many biologically active naturally occurring and synthetic compounds. Herein, we disclose our investigations into new approaches towards the diastereoselective synthesis of highly functionalised tetrahydropyrrolo[3,4-a] carbazole derivatives, and the subsequent evaluation of their biological activities. Our synthetic methodology is based on an initial intermolecular Diels-Alder (D-A) reaction between a substituted 3-vinyl-1H-indole 1, containing an electron withdrawing N-protecting group, and a range of dienophiles. This key step

APA, Harvard, Vancouver, ISO, and other styles

29

Devaraj, S. "Synthetic & mechanistic studies related to rigid derivatives of cyclitols." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2492.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Dhondge, V. D. "Synthetic approaches for natural product lactones- mintlactones and artemisinin derivatives." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1996. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3022.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Sharma, P. "Synthesis of biologically active compounds: CCG and its derivatives, mitralactonine and development of synthetic methodologies." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2006. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2791.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Dolan, Peter L. "Synthetic applications of arene chromium tricarbonyl complexes." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:b93a815f-c71d-4e6c-965a-878a14788981.

Full text

Abstract:

This thesis investigates the use of arene chromium complexes as phenyl cation synthons in the synthesis of homochiral N-phenylamino esters, and the dianion formation of a series of complexed aryl ethers. Chapter 1 reviews the properties of arene chromium tricarbonyl complexes and discusses in detail the ability of some of these complexes to undergo nucleophilic aromatic substitution. Chapter 2 outlines the biological importance of homochiral N-phenylamino esters. The N-phenylation of a series of amino alcohols are first investigated both by direct reaction of haloarene complexes with amino alc

APA, Harvard, Vancouver, ISO, and other styles

33

Robinson, Ross Stuart. "Baylis-Hillman derived benzopyrans and related systems : a synthetic and mechanistic study." Thesis, Rhodes University, 1998. http://hdl.handle.net/10962/d1007193.

Full text

Abstract:

The Baylis-Hillman reaction between substituted salicylaldehydes and various acrylate species has been shown to afford complex reaction mixtures, careful chromatography of which has led to the isolation of an extensive range of novel compounds. One- and two-dimensional NMR spectroscopic, mass spectrometric and X-ray crystallographic analysis of these compounds have permitted identification of no less than eight general classes of chromene and coumarin derivatives. The formation of the various product types is attributed to cascades of successive reactions stemming, in each case, from a Baylis-

APA, Harvard, Vancouver, ISO, and other styles

34

Zhou, Yuan. "Synthetic studies towards homotyrosinol sulfonamide derivatives via Heck-Mizoroki coupling reactions." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/16838.

Full text

Abstract:

Homotyrosine, as a nonproteinogenic α-amino acid, is present as a component of diverse natural products that have important biological activities. Therefore, homotyrosine and its derivatives are important precursors for the total synthesis of some natural products. However, up to now, there was no report concerning a reliable synthetic route towards the synthesis of homotyrosine or its derivatives in a preparative scale. In this thesis, a robust method was developed for the preparation of homotyrosinol derivatives and related intermediates through a Mizoroki-Heck coupling reaction between an

APA, Harvard, Vancouver, ISO, and other styles

35

Yu, S.-W. A. "Synthetic, structural and dynamic studies of iron carbonyls and their derivatives." Thesis, University of Essex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371925.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Weaver, George William. "Investigations of new synthetic routes to imidazo[4,5-b]pyridinone derivatives." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/12144.

Full text

Abstract:

This thesis is concerned with the development of three new synthetic routes to highly functionaliscd imidazo[4,5-b]pyridinone derivatives of biological interest as purine antagonists. The first synthetic route developed was based on the construction of 5-nitro-6-methylthiopyridine derivatives by annulation of readily available l-amino-l-methylthio-2-nitroethenes with 1,3-bis-clectrophiles (e.g. mal-onyl dichloride). Although this new type of ring formation was successful, the yields of the new pyridine derivatives obtained were disappointingly low and studies to improve the efficiency of the c

APA, Harvard, Vancouver, ISO, and other styles

37

Scobie, Martin. "Investigations of new synthetic routes to cinnoline and fused cinnoline derivatives." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/14364.

Full text

Abstract:

The subject matter of this thesis is concerned with the investigation of new synthetic routes to cinnoline and fused cinnoline derivatives. A description of the results obtained in these studies is preceded in Chapter 1 by a survey of literature methods for the synthesis of cinnoline derivatives. Chapter 2 describes an investigation into the use of 2-nitroaroylformimidates as intermediates in the synthesis of 3,4-substituted cinnoline derivatives and in particular 2-amino-3-(2-nitroaryl)quinoxalines. The base-catalysed cyclisation of the latter compounds, to afford quinoxalino[2,3-<i>c</i>]cin

APA, Harvard, Vancouver, ISO, and other styles

38

Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

FOIS, BENEDETTA. "Natural and Synthetic Derivatives Targeting Microbial and Cancer-Related Key Enzymes." Doctoral thesis, Università degli Studi di Cagliari, 2020. http://hdl.handle.net/11584/284383.

Full text

Abstract:

The present study is focused on the isolation and structure elucidation of bioactive natural compounds as well as on the semi-synthesis and synthesis of new derivatives as inhibitors of HIV-1 Reverse Transcriptase, Carbonic Anhydrase, DNA Gyrase, and human Rinoviruses replication. As regards the first target, we found that the EtOAc extract of the Sardinian plant Teucrium flavum subp. glaucum was able to inhibit the HIV-1 RT associated RNase H function. A bioassay-guided fractionation of the extract yielded six secondary metabolites and, among all, the flavone Cirsiliol was the most potent in

APA, Harvard, Vancouver, ISO, and other styles

40

Sharma, A. K. "Studies towards antitumor quinoline derivatives and development of useful synthetic methodologies." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2001. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2319.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Carter, James. "A New Synthetic Pathway Towards Legionaminic Acid." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/381511.

Full text

Abstract:

This thesis describes the results of a PhD project aimed at researching a new synthetic pathway towards legionaminic acid analogues. Legionaminic acid is a bacterial family of nonulosonic acids expressed in a terminal position on the flagellar glycans and are considered to be a virulence factor in the pathogenic bacteria that possess them. At the outset of this project several examples of Leg synthesis had been published. Whilst three syntheses of Leg derivatives have been published while the research described in this thesis was being carried out, the potential of all the published syntheses

APA, Harvard, Vancouver, ISO, and other styles

42

Stanfield, Charles Freeman. "Synthesis of alpha-amino aldehydes as kallikrein inhibitors; synthetic methods for preparation of beta-substituted cysteine analogues." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184738.

Full text

Abstract:

The first half of this dissertation describes the synthesis and biological activities of a series of amino aldehydes; which were derivatives of the basic amino acids, arginine, lysine and ornithine. The synthesis of the amino aldehydes was complicated by the difficulty of producing an intermediate oxidation state (the aldehyde) in the presence of two other functional groups (the α-amino, and the side chain functionality). The amino aldehydes were of biological interest due to the fact that they were inhibitors of the proteolytic enzymes called kallikreins. The kallikreins are known to be invol

APA, Harvard, Vancouver, ISO, and other styles

43

Ilupeju, John Oluwafemi. "Synthesis and use of new chiral DABCO derivatives for asymmetric fluorination." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1ee07d47-49ce-4072-a739-c20857d3b468.

Full text

Abstract:

In this thesis, the synthesis, reactivity and enantioselectivity of novel chiral Selectfluor Analogues were investigated. Chapter 1: Discussed is a general introduction to Selectfluor as an achiral electrophilic fluorinating reagent and its role as an oxidant in a wide variety of transformations and summarises the aims and objectives of the project. Chapter 2: The synthesis of chiral 2-monosubstituted, 2,3-disusbstituted and 2,5-disubstituted DABCO derivatives is described. We selected two strategies to prepare these chiral analogues of DABCO. Strategy A takes advantage of a large range of com

APA, Harvard, Vancouver, ISO, and other styles

44

Hall, Tiffany M. "Exploration of Synthetic Routes to the Sulfoxide and Sulfone Derivatives of Benzotrithiophenes." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1220816774.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Kilikli, Ahmet Alper. "Development Of New Synthetic Methodologies For Indole Derivatives: Chemistry Of Homophthalic Acid." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12611521/index.pdf.

Full text

Abstract:

Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besides this, another objective is to observe and discuss effects of two different substitue

APA, Harvard, Vancouver, ISO, and other styles

46

Shimizu, Hiroshi. "Development of New Synthetic Reactions Using Rhodium Catalysts and Organoboronic Acid Derivatives." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/152524.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Grech, Jason Mark. "The synthetic applications of organomercurials arising by the cleavage of cyclopropane derivatives." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/33701.

Full text

Abstract:

Organomercurial esters 2a-c obtained from cyclopropyl alcohols la-c in three or five (depending on whether the system is cis or trans) steps, react with organocuprates via an intramolecular addition across the carbonyl bond to generate the corresponding lactolate. Quenching of the latter intermediate with water leads to the lactol 3a, c in the cycloheptane and cyclopentane series, whereas the open hydroxyketone 4b is formed in the cyclohexane series. Quenching of the lactolate with BF3 Et2O gives different products, as demonstrated for the cyclohexane series. The Pd(II)-catalysed carbonylation

APA, Harvard, Vancouver, ISO, and other styles

48

Wiredu, Bernard. "A novel classical synthetic approach to carbon nanotubes and their functionalized derivatives." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1706.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Tamboli, M. I. "Acyl transfer reactions in hydroxyl ester derivatives, their analogs and the investigation of the synthetic potential of rigid inositol derivatives." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2265.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Dong, Jian. "Photochemical and Photophysical Studies of Synthetic Derivatives of the Green Fluorescent Protein Chromophore." Diss., Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24655.

Full text

Abstract:

We have synthesized dimethyl derivatives of the GFP chromophore (p-HOBDI) and several of its derivatives, and their photochemistry and photophysics were investigated using various steady-state and time-resolved techniques as follows. We first consider the effect of the £]-barrel on the optical properties of the GFP chromophore (p-HOBDI) experimentally by selective variation of the protonation state of chromophores and different solvents. Each of these forms shows a complex solvatochromic behavior and is governed by both polar and acid/base properties of the solvents. In contrast to their sol

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!